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megamikethomson · 4 years

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Agencies and houses in Valencia compete for the erotic market

Valencia is one of the nerve centers of prostitution and activities related to company services of the highest level at the state level, being one of the cities that present one of the largest sets of proposals launched by independent professionals, apartments, houses and above all for some time, the most prestigious and well-known national company service agencies have been.

The presence of some of the main relaxation houses in some of the most central and crowded areas of the Valencian capital, make it clear that not only this type of pleasure settings have been fully integrated into Valencian society, being the fruit of encounter for many lonely men, unfaithful married people and executives who do not miss the opportunity to satisfy their needs and even close economic agreements and deals in the luxurious and comfortable rooms presented by these whorehouses.

What are the advantages of relaxing houses?

The escort houses or vulgarly known also as whore houses in Valencia are one of the most recurrent and present elements in the landscape of the city, many of these points being true complexes and temples of pleasure in which they can be found from chalets to even blocks of buildings designed to satisfy the erotic fantasies of a growing group of regulars.

Whether your facilities are larger or smaller, all of them are governed in general terms by meeting and following absolute minimums of quality and availability, minimums that we will see below.

We are not closed in whole year

Unlike many other erotic anonse and sexual proposals present in the erotic market of the city of Valencia, the relaxation houses present a more than wide and varied group of young ladies who can attend us 24 hours a day, a fact that of course it conflicts with those escorts or independent prostitutes who cannot cover the entire time slot for obvious reasons and also with some agencies that can exclusively plan appointments and meetings with the models represented within a specific time.

Although many of these houses can become meeting places, they do not stand out precisely for enjoying a decoration and facilities that stand out from the normality, the presence in the city of Valencia of thematic spaces of pleasure such as the sexdupy.pl house or the facilities of the complex highlighted by “Evenonce” have forced the vast majority of agencies and relaxation houses that have opened their doors recently or in recent years in the city to have made an effort to acquire that degree of exclusivity or glamor that characterizes so much some of the existing suites in the houses mentioned above.

Luxury and comfortable environments are some of the maxims that regular customers of this type of pleasure center expect to find, either due to a completely justified relationship of ideas based on the experience previously lived with the oldest and most luxurious houses in the city. city, or simply to justify - apart from the excellent presence and beauty of the companions present in this type of sexual encounter venues - that the benefits obtained from this activity are re-invested in improving not only the staff of companions, but also to substantially improve the facilities and infrastructure presented for the development of sexual activities.

Great variety of escort girls

The fact of covering the total time slot of the day generates additional work for those responsible for this type of space, who are forced to constantly fill vacant positions, in order to cover all established shifts.

Although many of the young women who provide their services in this type of relaxation house can stay overnight and even live in the same facilities, they do not have the obligation to cover all the time slots or what is the same as working 24 hours of the day. It is for this reason that many relaxation houses announce the presence of the girls in the different shifts on a punctual and daily basis, both on their web pages as well as on social networks, so that their users / regular clients have direct knowledge about the companions who will be present at a certain time of the day. However, if it is impossible to make such a consultation, in the houses the managers or managers may suggest or present the girls available at the time of hiring in order to choose the right escort much easier.

Elegancy models - Luxury escorts in Valencia

What are the advantages of escort agencies? The company service agencies ogloszenia, although they can provide and present in the same way a set of facilities so that sexual encounters can take place in a comfortable, luxurious environment and with all the guarantees of security and privacy, do not operate in the same way. The same way as the whorehouses in Valencia and although it is possible to make prior appointments in different time frames, the attention to the public by the agencies is generally not extended 24 hours a day.

However, company service agencies have a host of qualities that make them one of the main sources of pleasure today not only in Valencia but throughout Spain.

Greater diversity and number of companions Although in the relaxation houses or hostess the number of companions may be completely limited to the facilities presented by the house itself, in the case of agencies this type of limitations established by the infrastructure are completely non-existent.

The number of companions or models represented by the agencies can in many cases exceed twenty and in cities like Valencia and even exceed thirty models represented in cities like Madrid or Barcelona in some exclusive company service agencies. In reality, there is no defined maximum number to be incorporated in the different Spanish cities or regions, only the service capacity and portfolio of regular clients of these agencies may mark the need for new incorporations.

Escorts who have unmatched beauty and physiques

In the Valencia escort agencies we can find mainly photography models who combine their regulated work activities with this activity and although they are not or have never worked as models, the reality reflected by the physical qualities of these beautiful young women makes us think that if this is the case it is because they have not actually tried.

The beauty, degree of education and elegance embodied by the escorts that are part of the staff of some of the most prestigious agencies in our country, make it clear that there is a clear difference between luxury prostitution and the services offered by the escorts.

A matter of time and above all economic

Having reached this point, many of you will wonder where to go? Well, the answer is actually more than simple. Everything will depend on our economic capacity and what time of day it is.

The services offered by many luxury escort houses, such as Felina; they can have rates per hour of service very similar to those presented by some of the models presented by some of the company service agencies present in Valencia.

#anonse #ogłoszenia

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s4g2 · 4 years

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Why SEO experts are considered to be good investments?

Getting huge traffic to your newly created site is not an easy task. It is a known fact that more traffic to your site means more conversions and revenue. The reputed & well established Seo Company like S4G2 Marketing Agency will make sure that your site is optimized thoroughly and enjoys desired results.

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Since search engine optimization efforts require putting in hard work, effort and are time consuming as well as involve good amounts of money, it will be essential to hire only a provider having adequate experience & knowledge of the domain. They should know what to do & avoid, and use those legible little tricks to increase your site ranking & visibility.

Profits tripe initial investment

Shrewd entrepreneurs are aware of the importance of optimizing their sites. This is something possible only with the services offered by the top SEO agency. There are many site owners who take that DIY route to optimize their site. Either they do not witness significant results or simply end up destroying their site value due to wrong approach taken. Being good at what they know, the experts will make sure that your site rises to and remains at top of the search engine rankings as early as possible. Hence, identifying a good provider assuring guarantee on their services can be termed to be a smart business savvy move. It only ensures that your investment is safe and multiples over time.

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Once traffic is attracted to your site, the next aspect is to come up with a visually appealing design and interesting contents relevant to your business. Several specialists do offer web design and fresh personalized contents as desried. However, before selecting SEO Services, going through the provider’s site & check their portfolio is essential. This way, you know who is being hired for the project & if they are really worth the investment or not.

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manhattantravelingnotary · 2 years

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Why Choose Neon Signage For Your Small?

A man cave is not merely a starting point relax, it's also a reflection of your own tastes. Regardless of whether in a garage, attic, spare room or also a basement, your guy cave can show who you are and a great way to do products by displaying neon signs. The following will help you in your search for ideal neon sunlight. The city of Madrid, Spain, has an ordinance that prohibits all illuminated signs in the city's center so as to reduce contamination, conserve energy, and help make matters the city more aesthetically pleasant. This ordinance covers all neon used in pharmacies, theater marquees, business signs, and bars. Madrid had had illuminated signs for over 70 years up to this date.The city of Duluth, Georgia prohibits neon signs, and even though these signs are not prohibited in Mesa, Arizona the city's present day ordinances and policies weigh heavily opposed to the survival of illuminated precursors. Using Custom Neon Signs is an easy way to advertise the opportunity. It doesn't need to have several details near the sign. Putting the name of business on the sign will make people aware of your establishment. It is an ideal method to inform probable customers by some graphic signs describing the category of business you posses. If experience that the billboard hoardings are enough then think about this- Your usual billboards get repaired frequently and to change it out once in 3 years but these bright Business neon lights last longer up to 30 years and consume little or no amount of electricity. If you are hungry the actual night then away and seeing these signs with pizza, hamburger, pasta, seafood and chicken designs in them can direct you to the correct food joint or commercial kitchen. If you are craving for some midnight snack then seeing ice cream neon signs and hotdog signs can provide a big sigh of support. You know you'll be led for ice cream parlor and hotdog joint in instantaneously. People, particularly who do not need issues yet about their income taxes will not spend time looking the accounting firm and they may not even have an idea about this the category of business. And since not everyone are aware of this business, you have any use for to advertise it. You need different the public recognize how the firm offers income tax services a good income tax neon sign. In a lower priced and simple way, neon sign with customize details will specific help your online grow. This eye-catching signage can give your business the bright chances to gain success. It was completed in 1998 the actual MagneTek Company of Nevada. Many establishments prefer to use this sign due to its usefulness in promoting the web business. Simply, is anywhere that there additionally.

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foxbrands317 · 3 years

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Tora Operations Research Download

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PDF Download Operations Research: An Introduction (6th Edition), by Hamdy A. Taha

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Appropriate for a variety of junior and senior undergraduate and first year graduate courses in operations research. Among these courses are Industrial Engineering, Business Administration, Statistics, Computer Science, and Mathematics. Major revision is designed to meet the needs of beginning through advanced students with an emphasis placed on the formulation and applications aspects. Provides balanced coverage of theory, applications and computations of operations research techniques. Numerical examples are main vehicle for explaining new ideas with each numeric example followed by a set of problems. TORA and SIMNET software included in text. More than 1,000 problems.

Sales Rank: #3326726 in Books

Published on: 1996-12-27

Original language: English

Number of items: 1

Dimensions: 1.64' h x 7.23' w x 9.50' l, 1.10 pounds

Binding: Hardcover

916 pages

From the Publisher Major revision is designed to meet the needs of beginning through advanced students with an emphasis placed on the formulation and applications aspects. Provides balanced coverage of theory, applications and computations of operations research techniques. Numerical examples are main vehicle for explaining new ideas with each numeric example followed by a set of problems. TORA and SIMNET software included in text. More than 1,000 problems.

From the Back Cover The sixth edition of Operations Research: An Introduction continues to provide readers with a balanced presentation of the theory, applications and computations of operations research. The book uses case studies, accompanying software, and comprehensive exercises to explain the basics of operations research techniques. It includes much new material: Floyd's Shortest Route Algorithm, Goal Programming, Analytic Hierarchy Approach, Review of Probability, Probabilistic DP, Simulation Modeling, as well as updated versions of TORA software and the simulation language SIMNET II. A valuable reference book for professionals in a variety of fields, including Industrial Engineering, Business Administration, Statistics, Computer Science, and Mathematics.

About the Author

Hamdy A. Taha is a University Professor of Industrial Engineering with the University of Arkansas, where he teaches and conducts research in operations research and simulation. He is the author of three other books on integer programming and simulation, and his works have been translated into Chinese, Korean, Spanish, Japanese, Russian, Turkish, and Indonesian. He is also the author of several book chapters. His articles have appeared in Management Science, Operations Research, and Interfaces Institute for Operations Research and Management Science, Naval Research Logistics John Wiley & Sons, the European Journal of Operations Research International Federation of Operations Research Societies and the AIIE Transactions.

Professor Taha was named a Senior Fulbright Scholar to Carlos III University, Madrid, Spain. He received an Alumni Award for excellence in research and The Nadine Baum Faculty Teaching Award, both from the University of Arkansas, and numerous other research and teaching awards from the College of Engineering, University of Arkansas. He is fluent in three languages and has held positions in Mexico and the Middle East.

Most helpful customer reviews

19 of 20 people found the following review helpful. An excellent book By OR user I have used this book as a student some 20 years ago and continue to use it today in my line of work. I was surprised to read a CS student complaining that the book does not provide any LP theory. Huh! Apparently the reviewer did not go past the first two chapters because Chapter 7 gives all the necessary mathematical foundation for linear programming. The reviewer also talks about 'signedness' difficulty in the book, something I don't understand because 'signedness' is not a word in English. As for TORA, true the software is not an 'orthodox' Windows development per se particularly for CS majors, but I find it refreshing that it is desigend to eliminate the need for a user manual. And this perhaps is the reason TORA is designed that way. It is very easy to use, and it can be used interactivly (with instant feedback) to help the reader understand the algorithmic details of the different OR techniques. I might also add that I used TORA's LP and IP modules many many times and have compared the results with those from AMPL and Excel Solver. Contrary to the CS reviewer claim,TORA always gave the correct answers. In summary, this book explains the basics of OR (theory, applications and computations)in a clear, concise, and straightforward manner using multitudes of examples. It is no wonder that it has been a leading textbook worldwide for over 35 years.

17 of 19 people found the following review helpful. The Best Book, Period! By A Professor I just want to respond to the CS major from Denmark. If he/she is that knowlegeable about what OR should or should not include, what is he/she doing taking an introductory course in the subject? This is not a book about writing computer codes for algorithms to please CS majors. It is a book that offers a comprehensive treatment of all three aspects of operations research (theory, applications, and computations), and it does it admirably. Also, if the CS major has read past the first few chapters, he/she will find all the LP/IP theory he/she desires. I belive that TORA is one of the best tutorial programs I (and my students) have ever used. It is easy to use and it gives instant feedback to actions initiated by the user. Also, as far as I know, TORA always gives the correct answers. I am currently teaching an introductory class from Taha's book, and I am very pleased with it (not to mention that its page count is about half the size of the competition -- without loss of substance, I must add)

6 of 6 people found the following review helpful. ref: PIRATE version of Taha's book! By ABC I have learned the hard way that Taha's book is printed in two version: US edition and International Edition. Text material is exactly the same in both versions. Problem sections in the two editions are another story, in the sense that (1) the order of the problems is not the same and (2) the numeric data of most problems are not the same. The reason for this considerably aditional work (e.g., differnt solutions manuals and different solutions in the appendix) is simple: Deter the sale of international copies (usually much cheaper) in the US market. Having said that, the fact remians that Taha's book is one of the most oustanding references in the field.

See all 31 customer reviews...

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PDF Download Operations Research: An Introduction (6th Edition), by Hamdy A. Taha

Operations Research: An Introduction (6th Edition), by Hamdy A. Taha

PDF Download Operations Research: An Introduction (6th Edition), by Hamdy A. Taha

Sales Rank: #3326726 in Books

Published on: 1996-12-27

Original language: English

Number of items: 1

Dimensions: 1.64' h x 7.23' w x 9.50' l, 1.10 pounds

Binding: Hardcover

916 pages

About the Author

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Tora Operations Research Download Software

Most helpful customer reviews

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architectnews · 3 years

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reTHINKING competitions: Lençóis Maranhenses Kitesurf School

Rethinking Architecture Competition, Nuevo Concurso, Spanish Architecture Contest

reTHINKING competitions

Lençóis Maranhenses Kitesurf School Design Contest – Concurso 2021

9 Apr 2021

reTHINKING competitions News

Lençóis Maranhenses Kitesurf School international architecture competition

# 024 KITESURF SCHOOL LENÇÓIS MARANHENSES

INFORMATION

The Lençóis Maranhenses Kitesurf School contest proposes a space where you can experience the relationship between sport, nature and the human being. The project must highlight the uniqueness of the place and that it becomes a space where there is comprehensive respect for the entire landscape, culture and atmosphere of the place.

This last point is important since tourists from Europe or America come to the place constantly interested in knowing the place and in fact it is such an inaccessible place that it is normal to make small camping in the area. That is why this kitesurfing school has to allow itinerant accommodation of people, but without excessive contamination of the place.

PRIZES – 5000 Euros

A special recognition will be made for the 13 best proposals, awarding a prize of a total of € 5,000 distributed as follows: First prize – € 3,500 (€ 1,500 cash + € 2,000 MArch programs) Second prize – € 1,000 Third prize – € 500 + 10 Honourable mentions

CALENDAR

APRIL 5, 2021: Early Registration Start MAY 4, 2021: End of Early Registration MAY 25, 2021: End of Medium Registration JUNE 15, 2021: Late Registration End JUNE 15, 2021, 6:00 p.m. (Madrid time): Delivery limit JULY 2021. Winners Announcement

JURY

Pablo Camarasa – MArch Research Vicent Molins – Director of Agència Districte Carmen Moreno Álvarez – Doctor Architect Ana Gea and Victor Palau – Gràffica.info Team

9 July 2020

reTHINKING competitions News

Vietnam Ricefield Lodge international architecture competition, South East Asia image courtesy of architects Vietnam Ricefield Lodge architecture competition The Vietnam Ricefield Lodge competition presents a space where the relationship between nature and human can be experienced.

reTHINKING Notre Dame Competition Paris reTHINKING Notre Dame Competition Paris

6 Apr 2018 Ibiza Artist House Architecture Competition

For the 3rd time, MArch Valencia has relied on reTHINKING competitions to organize a competition where, in addition to the prizes, a scholarship is awarded for one of its Architecture programs.

This new architecture contest is # 016 Ibiza Artist House.

image courtesy of reTHINKING competitions

Site – Pirate Tower

The pirate tower, in Ibiza, is one of the most famous defensive constructions on the island, which every year attracts hundreds of tourists who want to visit the well-known defense tower. Its true name is the Torre de Es Savinar or Cap d’es Jueu, and it is the highest tower in Ibiza, although its main attraction is that from the top of the tower you can enjoy a unique view of the islet of Es Vedrà and It is Vedranell, and you can even see the massif of Montgó de Denia on the clearest days.

Being a defensive construction, the area has cliffs, areas with a softer slope and last areas in direct contact with the sea in its lower part, exactly the lower bay. That is why the place of intervention to develop the proposal will be totally free where the contestant must choose how to settle their architecture and get the most out of the place by choosing what kind of strategy to follow.

Program

It is the fact that this place is one of the most inspiring that we can find on the island, the reason why it has been decided that it is an ideal point to develop a home conceived as a space of relaxation, of inner peace where culture, passion, art can flow thanks to the architecture that is proposed. Being a point of visual, musical or physical creation for an artist (architect, musician, poet, painter, ..).

The proposal can be conceived as an occasional refuge-house or as a permanent home for its inhabitant. That is why the contestant will decide on the one hand the profession of his tenant, then decide the exact location of the house and finally the program, taking into account that they must develop at least the following spaces: 1 room – studio – living room – dining room, 1 viewpoint, 1 bathroom

PRIZES – 5000 Euros

2000 Euro Grant for the International Master’s degree MArch First prize 1.500 € 3 Accésits: 3 x 500 € 10 Honourable Mentions

youtube

reTHINKING competitions Ibiza Artist House Architecture Competition

17 Feb 2018

Rethinking Competition in 2018

PIAM Architecture Competition

After the success of participation in previous editions, Matimex announces another year of PIAM, the International Architecture Prize dedicated on this occasion to the Contemporary Commercial Spaces.

Architecture has always been linked to trade: from the first ephemeral stores that were settling in squares forming souks to the current large commercial spaces. Our society, always in continuous evolution, is increasingly demanding.

It is not only about acquiring the product, but also about living an entire shopping experience. That´s why we are looking for a global design that goes beyond the product and that understands it as a whole with the brand, the space and the sensations experienced.

This change of focus entails an evolution of the commercial space linked to these new needs of the consumer. New commercial spaces for new user needs.

We propose to design a space or recover an existing one, whose design revolves around the main theme of the contest: “ComerciARQ. Contemporary Commercial Spaces “.

The company, from Iris Ceramica Group, wants to show its support to environment with the contest. The use of products with finished ACTIVE Clean Air & Antibacterial Ceramic will be consideredan advantage. And the use, in the projects, to the certification LEED or BREAM; the jury also will evaluatein the projects the quality, originality, creativity, and the correct use to the products from the Iris Ceramica Group.

This prize is addressed to professionals and students associated with the architecture, technical architecture, design, interior design, engineering and with similar profiles with this characteristics. The jury is composed withinternational professionals associated with the architecture, the design and the sustainability:

1. Enric Batlle. Bachelor Architect, Director of University Master of Lanscape UPC- MBLandArch. Partner of Batlle i Roig Arquitectura. 2. Margarida Caldeira. Architect. Board Director EMEA Chair. Broadway Malyan 3. Lucia Ferrater. Partner Architect OAB 4. Diego Gronda. Architect and designer. Partner of Studio Gronda 5. Josep Piñot. Industrial Engineer. Director Retail Development Services CBRE 6. Juan-Luis Grafulla. Matimex CEO and General Manager. 7. Dottoressa Federica Minozzi. Iris Ceramica Group CEO, Italy.

The prizes, in net amount:

• Professional category: 1st prize: 3.000 € 2nd prize: 1.000 € 1st Honorable mention: no cash prize 2nd Honorable mention: no cash prize

• Students category: 1st prize: 1.000 € 2nd prize: 500 €

The inscription and delivery: from 29 January – 7 May

PIAM’s web site: www.premiosmatimex.com

reTHINKING competitions José Laguillo, 21 Sevilla, Se 41003 Spain

Dec 27, 2017

Rethinking Competitions – Lanzarote Dynamic Square

# 015 Lanzarote Dynamic Square

The Cabildo of Lanzarote has been trying since 1989 to reactivate and enhance the cultural attractiveness of Arrecife. The main objective of this project is to convert the El Almacén plaza (Arrecife) into an urban point of culture and social meeting. And with this contest it is intended to take an important step for it since the proposal will be built.

Lanzarote Dynamic Square Competition

29 Sep 2017

Rethinking Competitions – Sahara Eco House

Rethinking Competitions – Sahara Eco House Contest

English text (scroll down for Spanish):

We are happy to inform you that reTHINKING has launched a new competition: Sahara Eco House. This is an architecture competition where a new concept of housing must be projected that maximizes the passive systems to achieve the necessary comfort in houses in extreme climates such as deserts and in particular in the Sahara.

image from architectural contest organisers

This is a novel contest that can encourage reflection on issues that are growing in current architecture thinking such as zero consumption and passive consumption as a whole. Please see below the most relevant information:

PRIZES First Prize 1.500 € + Member of the jury for the next competition 3 x Accesits: 500 € + 10 Honourable mentions • Magazines publications • Publication in blogs/ architecture web

CALENDAR September 14th 2017: Early registration starts December 4th 2017 Submission deadline

JURY Guillermo Rubio Boronat (Editor – Coordinator TC Cuadernos) Beatriz Pérez Doncel (Terral Arquitectos) Victor Moreno Jiménez (Professor at the ETSAS) rubial-Sánchez. Architecture and design studio You can check all the information in our website: https://ift.tt/1LM1Lc0

Spanish text:

Rethinking Nuevo Concurso

RETHINKING_#014 NUEVO CONCURSO

Septiembre 2017 – Desde reTHINKING competitions nos complace anunciaros nuestro nuevo concurso: “#014 SAHARA ECO HOUSE”.

Se trata de un concurso donde se debe proyectar un nuevo concepto de vivienda que aproveche al máximo los sistemas pasivos para logar el confort necesario en viviendas en climas extremos tales como los desiertos y en particular en el Sahara.

Consideramos que es un concurso novedoso que puede hacer reflexionar sobre temas que son crecientes en la arquitectura actual tales como la viviendas de consumo cero y pasivas en su totalidad.

A continuación os dejo los datos más relevantes:

PREMIOS

Primer premio 1.500 € + Jurado del próximo concurso rethinking 3 x Accésits: 500 € + 10 Menciones de Honor

• Publicación en revistas • Publicación en blogs/ webs de arquitectura • Publicación oficial de reTHINKING

CALENDARIO

14 de Septiembre 2017: Inicio Inscripción Temprana 4 de Diciembre 2017 Límite de entrega

JURADO

Guillermo Rubio Boronat (Editor – Coordinador TC Cuadernos) Beatriz Pérez Doncel (Terral Arquitectos) Victor Moreno Jiménez (Professor Proyectos arquitectonicos ETSA Sevilla) rubial-Sánchez. Oficina de Arquitectura y diseño

Una vez más os pedimos que difundáis la noticia para animar a los estudiantes y jóvenes arquitectos a participar. Para cualquier duda o solicitud quedamos a vuestra disposición,

reTHINKING competitions

Rethinking Competitions 2019

Location: Seville, Spain

Architecture Competitions – Selection

Archasm Amsterdam Art Bridge Architecture Contest, Netherlands – International image from architectural contest organisers Archasm Amsterdam Art Bridge Architecture Competition

7th Advanced Architecture Contest image courtesy of architects Advanced Architecture Competition

Adelaide Contemporary International Design Competition photo © davidwallphoto.com Adelaide Contemporary International Architecture Competition

Gasholder bases international ideas competition Gasholder architecture competition

Museum Of Architecture Competition

Rethink Hotels Competition

Architecture

Austrian Architecture

Hungarian Architecture

Vienna Building image © COOP HIMMELB(L)AU

Comments / photos for the Rethinking Competitions – Sahara Eco House Architecture Contest page welcome

Website: Architecture

The post reTHINKING competitions: Lençóis Maranhenses Kitesurf School appeared first on e-architect.

#e-architect

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onlineprestige · 1 year

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If you're looking for a reliable graphic design services in madrid spain that prioritizes quality workmanship above all else, look no further than Online Prestige Management.

#Graphic Design Services in Madrid Spain #web design services Madrid Spain

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heypapipromotions · 4 years

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News Alert! We are announcing the launch of our NEW Responsive-design Website.

It’s here!

The Hey Papi Promotions Network Announces the Launch of our NEW Responsive-design Website.

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The new website is interactive and gives better access to new features like; Events including Zoom meetings, Profile Page Design (adding a Bio, Service, Website, etc.) + Blogs/News/PSAs + Celebrity Highlights + Bookstore + Music Store + Chat Room + Prayer Room + Job Board + Videos + Partners/Sponsors + Scholarships & Grants + More...

Amongst the new features, the site contains integrated social media buttons for Facebook, Twitter, and Linkedin to foster improved communication with external social media platforms. Members can now post their content in categories of Blogs, Articles, News, Press Releases, Classifieds, or Public Service Announcements to help the Media and Journalists identify what they need to publish, etc.

Special Thanks to our member's family participating in this photo; Howze Family (Maryland, USA), Green Family (Maryland, USA), Hay Family (New Jersey, USA), Christie Family (Maryland, USA), Gore Family (North Carolina, USA), Wade Family (Maryland, USA), Santana Family (Feira de Santana, Brazil), Deguzman Family (Madrid, Spain), Peters Family (Managua, Nicaragua), Harvey Family (DC, USA), Lourim Family (Maryland, USA), and Aguiar Family (Joinville, Brazil).

We hope you enjoy the new website with its fresh look and easy-to-access material. Please share this news with other members including your family and friends! Come and visit us at https://heypapipromotions.com

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joehas · 6 years

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Talk To Me When You Scale: Since Big Is Now Favored Over Small, Is It Time To Ignore Startups?

APRIL 30, 2018 INNOV8RS TEAM

Apart from some exceptions, the results for corporate-startup collaboration have been generally disappointing.

But Joe Haslam believes there is hope – and his optimism comes from experience. Not only is he a professor at IE Business School in Madrid, where he teaches founders and MBA students how to scale their startups, he has co-founded and grown a number of companies including Marrakech.com, which raised over $75m in Venture Capital, and Hot Hotels, the first startup founded in Spain to be accelerated by the Techstars program in the USA.

According to Haslam we’ve paid more than enough attention to startups and enterprises, and nowhere near enough to the scaleup phase: how a startup grows into an established, sustainable company.

So what is a scaleup exactly, and what distinguishes it from a startup? And how can corporations identify and work with scaleups in a way that benefits both? At Innov8rs Tel Aviv, Haslam walked us through it.

Startup vs Scaleup

Steve Blank defined a startup as “an organization formed to search for a repeatable and scalable business model.” A startup is not just a smaller version of a big company. It is an organization set up to run experiments.

“When someone sends me a business plan that looks like it’s for a big company, I send it back to them and ask them to give me a list of the experiments they are running, “says Haslam. “What’s your insight, your hypothesis? That’s really all I care about.”

So when does a startup become a scaleup? It has nothing to do with how long you’ve existed as a company, or how many products you have, or even your profitability.

You become a scaleup when you achieve heavy engagement – in other words, product-market fit – and you stop doing what’s not working in order to double-down on what is.

“People ask me to come in for a two-day workshop and at the beginning of the first day I realize they have all these products they don’t need,” says Haslam. “I say ok: you need to snip this product and emphasize the stuff that’s working. That leads to product-market dominance, and that leads to being an enterprise.”

Haslam outlined five ways a scaleup is different to a startup:

1. Startups are about putting out fires – in other words, survival. Scaleups are about lighting fires – looking for and taking opportunities. 2. Startups experiment to find out where they’re strong. Scaleups try to find out where they’re weak. 3. Startups need generalists – people who can do a bit of everything. Scaleups need specialists – people who know more about their particular area than most people in the world. 4. Startups experiment. Scaleups simplify. 5. Startups can make you famous. Scaleups can make you rich.

Growth doesn’t make you a scaleup

Uber. AliBaba. Airbnb. These companies are often brought up as examples of why corporations need to get with the innovation program. But are they the disruptive forces we’ve made them out to be? According to Haslam, the evidence says no.

“Anything that grows really fast can collapse just as fast. And when we actually look at the reality, all that’s happened with these companies is that they’ve grown really fast.”

Uber is considered the most valuable venture-backed technology company in the world; it became the world’s largest taxi company in just nine years, without owning any vehicles. But according to data compiled by Bloomberg, Uber has ‘Peter Pan’ syndrome: though it has reached a stage most startups never realize, it has yet to turn a profit. The company has long been subsidizing rides; in some markets, customers paid just 41% of the true cost of their trip. Deep discounts like this can create an artificial signal about the actual size of a market; in fact, when Uber alerted passengers that fares had doubled, usage dropped by 40%.

If customers are only using your service because it’s priced cheap, and that pricing is not profitable or sustainable, can you really claim success?

“Growth can actually be a destructive thing,” Haslam points out.

“Edward Abbey said: growth for the sake of growth is the ideology of the cancer cell. Innovation is moving quickly – but if it’s not sustainable, then it’s not a good thing.”

That said, Uber has caused disruption in the taxi industry. But what about Airbnb? Several years ago, everyone thought Airbnb was going to turn the hotel industry on its head, if not make it obsolete. But hotels have continued to thrive, with 2017 seeing both hotel occupancy and stock prices climbing.

Small, and want to grow? Big, and want to hold on? Get the basics right. Most companies aren’t disrupted simply because a faster moving, faster growing startup appears on the scene and they’ve failed to keep pace and innovate. In Haslam’s experience it’s bad management that kills companies, not disruptive startups.

“Most companies are disrupted because they don’t see the blindingly obvious. They fail at the general, basic management stuff.

They don’t know how many people work for them, or how many products they have, but yet they want to talk about innovation. Before you start talking about incubators and startups, you have to get your basic stuff right.”

Startups who fail to scaleup fail for similar reasons: good old-fashioned management skills. Haslam says “Everyone thinks they’re a good manager, but I despair at the number of people who just don’t learn the basics: how to interview properly, how to manage people, how to give feedback. It’s seen as a nerdy thing to be good at management.”

But if you want to scale up, you need the nerds. “MBAs generally don’t found startups, but they do generally scale them. If you look at the key moments in a lot of growth companies, generally it was a boring nerdy MBA who started to ask the basic questions. What are our R&D costs? When do we get paid? What are our capital ratios? Maybe they weren’t the person who had the initial inspiration, but they were certainly in there when the company scaled successfully.”

How to succeed at corporate-scaleup collaborations Focus on sustainability, not innovation

Haslam often sees companies, large and small, focus on innovation over sustainability – and to him, that’s completely backwards. “Sustainability, trying to work out how to make something sustainable, is much more interesting than innovation because you’re not trying to sell dollars for 80 cents, which is what innovation is for some companies. Actually applying the principles of sustainability gets you the innovation everyone’s talking about.”

As an example, Haslam cites Madrid-based sustainable clothing company Ecoalf. Founded in 2012, their goal was to create a new generation of recycled products with the same quality and design of the best non-recycled products. Along the way, they basically transformed into an R&D operation, figuring out how to make thread and fabric out of used tires, plastic bottles, old fishing nets, discarded cotton and wool, and post-consumer coffee grounds. In addition to their flagship concept store in Madrid, Ecoalf has recently opened another location in Berlin, launched both their Ecoalf Foundation and Upcycling The Oceans project, and has entered into partnerships with companies like Apple, Swatch, GOOP, Barney’s New York, and Coca-Cola.

Go in at the right time (it’s later than you think)

Haslam cautions against letting fear drive partnership or acquisition decisions. Though many think you need to get in with a startup within their first five years, in reality you need to give them plenty of room to grow – even when that growth seems potentially threatening.

“Companies make their real money in their later phases, could take ten years. Peter Thiel argues that the real value of Paypal is yet to be realized! Let these startups grow and, if they manage to get a product-market fit and hire experts, then it’s time to pay attention to them.

Let them do stuff that may threaten you so you can identify their value – there’s plenty of time to acquire them and realize that value.”

In fact, Haslam argues that startups shouldn’t be seen as a threat at all. “Some of the incubators I’ve seen were so far away from anything that was commercially viable. The most interesting companies have people with deep sector knowledge – they spend time working in an area and acquire deep knowledge that very few people have. Do most of these startups have that? Absolutely not.

That’s why the future is about scaleups. It’s about people who can get to a certain stage on their own. Let these startups go, let them prove themselves. Then you can start having the conversations.”

Embrace the era of the big…

Haslam points out that we’ve moved into a new era of exponential technology – self-driving cars, mixed reality, synthetic biology – that heavily favors the big over the small. And these technologies are not ‘startuppable’ in the same way previous innovations have been.

“This is not like Instagram, where you can have five people in a garage making filters and be worth a billion dollars. These technologies are big company things.

They require closer integration with corporates who understand regulation, who have specialists, who can put products using these technologies into their supply chain. We are starting an age where the big is favored over the small.”

…and ignore the startup hype

The shine of the startup is beginning to fade. Why? In part, because starting is so easy.

Haslam recounts how expensive it was to start his first company, Marrakesh, in 1999. As a provider of on-demand spend management solutions for retail and government they had to physically buy servers and build their own data center, and hire marketing planners and buyers. Now, you’ve got Amazon web servers, and can target people on Facebook. But while this drop in cost is good, it has been accompanied by a corresponding drop in quality.

“I thought, going back ten years, that more startups would mean more scaleups. What we’re learning is that more startups just means more startups. It doesn’t mean they’re going to be better.

In general, saying ‘I have a startup’ is about as interesting as saying ‘I’ve joined a gym’. Talk to me when you scale.”

Read this article on the Innov8rs website

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un-enfant-immature · 4 years

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TaxScouts raises £5M Series A to expand to Europe, first stop Spain

TaxScouts, the U.K. tax preparation startup founded by TransferWise and MarketInvoice alumni, has raised £5 million in Series A funding for European expansion.

Leading the round is Octopus Ventures, with previous investors SpeedInvest, Seedcamp and Finch Capital, following on. Also participating is Clocktower Technology Ventures, the U.S. venture capital firm specialising in financial technology.

Aiming to build a “pan-European” tax filing service, first stop outside the U.K. is Spain, with TaxScouts having already appointed a Madrid-based country manager. It says it has chosen Spain based on the size of the market and the complexity of the local tax system, and will expand to further European markets in the near future.

Image Credits: TaxScouts

Combining “automation” with a network of human accountants, TaxScouts’ service is designed to support you through your annual tax filing preparation and submission. The company charges a simple flat fee — currently £119 in the U.K. — and promises a quick turnaround, typically just 1-2 days.

To achieve this, the web app walks you through your tax status, income and expenses without assuming too much prior knowledge. This includes asking you to upload or take a photo of any required documents, such as invoices or dividend certificates. The idea is that all of the admin is captured digitally and packaged up ready for an assigned accountant to check.

TaxScouts says the new Series A investment will be used to develop the company’s Spanish service and make key hires across its engineering, product, and marketing teams.

Mart Abramov, co-founder and CEO of TaxScouts, comments: “We see a huge amount of potential in launching TaxScouts into Spain. Naturally, the weather and the wine were considered when picking the market, but having successfully built a solution for one of the trickiest tax systems in Europe, we are confident that we can deliver another great product for Spain’s complex tax structure. The market is double that of the UK, and this is the first step to us building a pan-European tax service”.

#TechCrunch

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wsmith215 · 4 years

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How scientists are using supercomputers to combat COVID-19

In March, IBM announced alongside the White House Office of Science and Technology Policy (OSTP) that it would help coordinate an effort to provide hundreds of petaflops of compute to scientists researching the coronavirus. As part of the newly launched COVID-19 High Performance Computing (HPC) Consortium, IBM pledged to assist in evaluating proposals and to provide access to resources for projects that “make the most immediate impact.”

Much work remains, but some of the Consortium’s most prominent members — among them Microsoft, Intel, and Nvidia — claim that progress is being made.

Petaflops of compute

Powerful computers allow researchers to undertake high volumes of calculations in epidemiology, bioinformatics, and molecular modeling, many of which would take months on traditional computing platforms (or years if done by hand). Moreover, because the computers are available in the cloud, they enable teams to collaborate from anywhere in the world.

Insights generated by the experiments can help advance our understanding of key aspects of COVID-19, such as viral-human interaction, viral structure and function, small molecule design, drug repurposing, and patient trajectory and outcomes. “Technology is a critical part of the COVID-19 research going on right now all over the world,” Thierry Pellegrino, VP of Dell Technologies, a member of the Consortium, told VentureBeat. “It’s crucial to the population of our planet that researchers have the tools to understand, treat, and fight this virus. Researchers around the world are true heroes doing important work under extreme and unfamiliar circumstances, and we couldn’t be prouder to support their efforts.”

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Companies and institutions matched 62 projects in the U.S., Germany, India, South Africa, Saudi Arabia, Croatia, Spain, the U.K., and other countries with supercomputers from Google Cloud, Amazon Web Services (AWS), Microsoft Azure, IBM, and dozens of academic and nonprofit research institutions for free. These are running on over 136,000 nodes containing 5 million processor cores and more than 50,000 graphics cards, which together deliver over 483 petaflops (430 trillion floating-point operations per second) of compute across hardware maintained by the Consortium’s 40 partners.

Microsoft

In addition to supercomputing infrastructure built atop its Azure cloud computing platform, Microsoft is providing researchers with networking and storage resources integrated with workload orchestration through Azure HPC. Concurrent with this is the company’s AI for Health program, which in April allocated $20 million to developments in five key areas — data and insights, treatment and diagnostics, allocation of resources, dissemination of accurate information, and scientific research — with the goal of bolstering work related to COVID-19.

As a part of its work with the Consortium, Microsoft says it’s providing teams access to its scientists spanning AI, HPC, quantum computing, and other areas of computer science at Microsoft Research and elsewhere. Much of these researchers’ work to date has entailed basic scientific discovery about COVID-19 itself and how it interacts with the human host, including the design of therapeutics, through:

Research simulations. Molecular dynamics modeling. 3D mapping of virus protein structures. Compound screening to see if existing drug molecules are able to inhibit cellular entry of the virus.

Microsoft says each organization it collaborates with receives a full Azure HPC environment, including Azure CycleCloud with the Slurm workload manager, best-fit Azure Virtual Machines, and storage. These are configured to scale on-demand and meet compute as necessary, and they’re tailored to the specific research needs of the grantee.

Nepali modeling and ventilator splitting

Through the Consortium, Microsoft’s AI for Health is supporting the nonprofit research institute Nepal Applied Mathematics and Informatics Institute for Research (NAAMII), which is employing simulation to model how COVID-19 would spread among the Nepali population, given different scenarios. These models, Microsoft says, can show patterns that might potentially save lives and livelihoods.

Duke University, another grantee, is leveraging Azure to investigate ventilator splitting, a technique that enables multiple patients to use the same ventilator. The Matlab division of MathWorks teamed up with Microsoft to optimize the researchers’ analysis for distributed computing environments.

Google

Google continues to provide compute, storage, and workload management services to Consortium grantees through Google Cloud Platform, and it recently set aside $20 million in computing credits for academic institutions and researchers studying COVID-19 treatments, therapies, and vaccines. As a part of its work with the Consortium, the company is collaborating on epidemiological modeling with Northeastern researchers and applying AI to medical imaging with the Complutense University of Madrid.

Google also partnered with the Harvard Global Health Institute to fund companies, government agencies, nonprofit organizations, and institutions working on COVID-19 research. The tech giant — along with Microsoft — also kicked off a program with Microsoft-backed cloud company Rescale to offer HPC resources at no cost to teams working to develop COVID-19 testing and vaccines. Rescale provides the platform that researchers launch experiments and record results on, while Google and Microsoft supply the backend computing resources.

Amazon

Amazon, like Google, is supplying compute and tools to researchers matched through the Consortium. Over 11 teams are currently using its infrastructure, and dedicated Amazon Web Services solution architects conference with the scientists every week.

As a part of its AWS Diagnostic Development Initiative, Amazon is also providing $20 million in computing credits to over 35 institutions and private companies that are leveraging AWS to further the development of COVID-19 point-of-care diagnostics — i.e., testing that can be done at home or at a clinic with same-day results. “This is a global health emergency that will only be resolved by governments, businesses, academia, and individuals working together to better understand this virus and ultimately find a cure,” said Teresa Carlson, VP of worldwide public sector at AWS, in a statement.

Developing protein decoys

At the MIT Media Lab, inspired by a researcher at Johns Hopkins University, a team is identifying “decoy” proteins of ACE2 receptors (the receptors coronaviruses bind to inside the human body) that might render COVID-19 inert. Using a machine learning model trained on data about the ACE2 receptor and running on AWS, the researchers are attempting to predict which variants of the decoy won’t interact with other proteins in the body and cause harmful side effects. If all goes well, tests in mice will commence soon, with clinical trials beginning toward the end of summer.

In separate efforts, AWS is empowering researchers at the Children’s National Hospital to combine hundreds of data sets to identify genes that might be targeted to treat COVID-19. A team at Iowa State University is tapping evolutionary models with public genomic data sets to suss out the relationships between strains of COVID-19 to understand how they mutate and spread. And scientists at Emory University are developing a web-based tool — tmCOVID — to extract and summarize key concepts in scientific studies on COVID-19.

Nvidia

Nvidia says that 14 of the Consortium’s projects have consumed over 3 million GPU hours on the Nvidia-powered Summit supercomputer at Oak Ridge National Laboratory. Summit is the world’s fastest supercomputer, as ranked by the Top 500 list of supercomputers. And it also offers its own 20,000-GPU infrastructure — SaturnV — which the company’s researchers are primarily using to optimize COVID-19 research applications

Nvidia has been using excess cycles on SaturnV to run Folding@home, a distributed computing project that simulates protein dynamics in an effort to help develop therapeutics for various diseases, including COVID-19. It has assisted in matching researchers to supercomputers based on each researcher’s specific requirements.

Quantum chemistry and virtual screening

In partnership with Microsoft, Nvidia is working with the University of California, Riverside on quantum chemistry solutions that benefit from GPU optimization. The number of possible COVID-19 inhibitors are immense, and carrying out experimental studies on all the candidates is both infeasible and cost-inefficient. The hope is that the project’s predictive, GPU-enabled simulations — which use up to 800,000 GPU hours on Azure — will provide guidance for efforts that narrow in on the most promising candidates.

According to Nvidia, in less than a week its experts helped project lead Bryan Wong’s package research code using HPC Container Maker, the company’s open source tool that ships with 30 containerized HPC applications. And they tapped Nvidia’s Nsight debugging tool to develop a fix for an onerous bug — making it possible to accomplish work scheduled to take 800,000 GPU-hours in 300,000 GPU-hours for a savings of $500,000.

At Carnegie Mellon University, a team led by Olexandr Isayev worked with Nvidia to apply AI approaches to the task of high-throughput virtual screening, which uses algorithms to identify bioactive molecules. Unlike traditional scientific simulations, which take a brute force approach to problems by attempting to simulate every possible combination of molecular interaction, AI makes educated guesses that reduce the number of combinations to be simulated. This leads to theoretically faster candidate drug discovery (and quicker field trials). Isayev estimates that it might be as much as a million times faster than usual mechanical calculations.

The first step in the process is using AI to analyze a library of molecules that can be purchased from chemical companies, preparing them for screening in simulation. The best candidates from the screening will then be simulated using AI-enhanced molecular dynamics, and top hits from the final screening will be tested in partner laboratories.

At the conclusion fo their work, Isayev and colleagues plan to deposit their data sets in the open source COVID-19 data lake, a centralized repository of curated data sets maintained by Amazon’s AWS division in hopes that other researchers will benefit from them.

IBM

IBM VP of technical computing Dave Turek says COVID-19 research continues with partners across the spectrum — on machines powered by its hardware and within laboratories and institutions it has relationships with. “Without any large contracts or anything of the kind, [the Consortium] came together in a way to both share resources and manage a process of expediting the scientific proposals that came into the consortia and match it to the best resources,” he said in a statement. “The teams are making rapid progress, and these supercomputing-powered projects are using novel approaches to understanding the virus.”

For example, IBM researchers at the Hartree Centre in Daresbury, England partnered with University of Oxford scientists to combine molecular simulations with AI in discovering compounds that could be repurposed as anti-COVID-19 drugs. Using Summit and the Texas Advanced Computing Center’s (TACC) Frontera, the fifth-fastest system per the Top 500, the team says they’re accomplishing months of research in a matter of hours.

Generating molecular compounds

With the help of IBM, researchers at the University of Utah tapped the National Center for Supercomputing’s Blue Waters and TACC’s Longhorn and Frontera to generate more than 2,000 molecular models of compounds relevant for COVID-19. They ranked the models based on the molecules’ force field energy estimates, which they theorized could help scientists design better peptide inhibitors of an enzyme to stop COVID-19.

The team investigated the structure of the virus’ main protease, an enzyme that breaks down proteins and peptides, in complex with a peptide inhibitor called N3. They then applied an approach developed to identify Ebola-stopping molecules that involves molecular dynamic simulations and optimization of specific structures. This enabled the COVID-19 protease to break down a series of similar, easy-to-detect probes that had already been designed, serving as the basis for assessments that test the inhibitors’ effectiveness.

The work built on a body of knowledge about how the potential energy generated by atoms can give a molecule a positively or negatively charged “force field” that attracts or repels other molecules. Using AMBER, a molecular dynamics code, the researchers observed experimental results within one hundred-millionth of a centimeter, a measure imperceptible to all but the strongest microscopes.

The University of Utah’s Schmidt lab will later transform the peptide leads into biopharmaceutical scaffolds called circular modified peptides. “Our hope is that we find a new peptide inhibitor that can be experimentally verified in the next couple of weeks. And then we will engage in further design to make the peptide cyclic to make it more stable as a potential drug,” University of Utah professor and research lead Thomas Cheatham said in a statement.

Mapping how COVID-19 spreads

It’s well understood that COVID-19 spreads via virus-laden droplets, which are transported around environments by air conditioning units, wind, and other forms of turbulence. But airborne transmission rates remain a subject of contention, and some experts say gathering useful evidence of airborne transmission could take years and cost many lives.

In a safer pursuit of clarity, scientists at Utah State University, Lawrence Livermore National Lab, and the University of Illinois intend to use the Consortium’s supercomputing resources to study person-to-person transmission of airborne respiratory infectious diseases like COVID-19. They are working from the hypothesis that aerosolized droplets from human airways contaminate rooms more quickly than initially assumed. They’ll leverage high-fidelity multiphase large-eddy simulations (LES) — mathematical models for turbulence used in computational fluid dynamics — running on IBM hardware to determine cloud paths in typical hospital settings.

The short-term aim will be to understand how long a cloud persists and where the particles settle, which could inform non-pharmacological techniques to reduce the spread. “The [goal] of this study is to fundamentally improve our understanding of person-to-person transmission of airborne respiratory infectious diseases,” wrote the researchers in a statement. “Our findings will [make] it safer for health care professionals.”

Studying genetic susceptibility

Beyond isolating COVID-19-killing compounds and mapping viral spread of the virus, researchers are attempting to define risk groups by performing genome analysis and IBM supercomputer-enhanced DNA sequencing.

A team of scientists affiliated with NASA have observed that COVID-19 appears to cause pneumonia, triggering an inflammatory response in the lungs called acute respiratory distress (ARDS). To test this, they plan to use the supercomputer at NASA’s Ames Research Center, which will sequence the genome on patients who develop ARDS and those who don’t.

If all goes well, the team believes their study will result in practical tools for predicting which COVID-19 patients are likely to develop ARDS, and therefore which patients are likely to need intensive support prior to the emergence of severe symptoms. Such tools could help guide intensive care resource usage for the sickest patients, and enable health care workers to better manage ongoing treatment.

Intel

Intel is actively involved in the design, development, and deployment of several Consortium-affiliated supercomputers, as well as the upcoming Aurora at Argonne National Laboratory in Chicago. The company says it has a staff of engineers working on code optimizations for HPC applications that include LAMMPS (a molecular dynamics code), Gromacs (a package for protein, lipids, and nucleic acids simulation), NAMD (another molecular dynamics code), AMBER, and others. Intel is also sharing tools, architecture knowledge, and software with partners to enhance COVID-19 applications and scale their performance on Intel-based hardware.

One specific area of focus for Intel is a collaboration with NAMD to release a version of the code that provides faster simulations on Xeon processors that support AVX-512. The company says the significant performance boost will allow researchers to achieve longer timescales in the simulation of relevant molecules associated with COVID-19, by extension enabling them to better understand aspects of viral infection with “atom-level” detail. The update is expected to be made public for early use in June.

Hewlett Packard Enterprise

Some of Hewlett Packard Enterprise’s (HPE) work is done through the Consortium, while the rest is focused on a number of customers and partners. As a result of its acquisition of Cray in September 2019 for approximately $1.3 billion, HPE claims it now has more supercomputers and HPC systems in use than any leading research center.

“High-performance computing is more powerful today than it’s ever been, and its massive computing power — along with other advanced capabilities — has significantly transformed drug discovery,” said Peter Ungaro, former Cray CEO and head of HPE’s HPC and mission-critical systems group, in a statement. “Supercomputing and HPC systems unlock greater potential for AI and machine learning applications, and when applied to 3D modeling and simulations, dramatically [accelerate] time-to-insight and [increase] scientific outcomes. Our work within the consortium provides the researchers with HPC capabilities they wouldn’t normally have access to independently to help fast-track the discovery of a cure for the pandemic.”

Drug design research

In partnership with Microsoft, HPE is working with a team at the University of Alabama in Huntsville (UAH) to supply its Sentinel supercomputer through the Azure cloud. With the supercomputer, along with a team of dedicated HPE experts, it’s supporting various stages of the drug design process at UAH.

The researchers are employing a molecular docking approach, a kind of bioinformatic modeling that involves the interaction of two or more molecules to yield a stable combination. Drawing on a large, open set of natural products found in plants, animals, fungi, and the sea, Sentinel is performing calculations to determine how natural compounds interact with COVID-19’s protein. Previously, 20,000 molecular dockings could be improved against a protein target in seven or eight minutes, versus the full 24 hours it used to take. Now, the research team can perform as many as 1.2 million molecular dockings per day.

Elsewhere, HPE is supporting work at the Lawrence Livermore National Laboratory with the Theta supercomputer, which is housed at the Argonne Leadership Computing Facility. The researchers’ goal is to apply AI to accelerate the process of simulating billions of molecules from a database of drug candidates. They’ve narrowed down the number of potential candidates from 1040 to a set of 20, and they’ve tapped Catalyst — an HPE-powered HPC cluster that generates predictions like experimental and structural biology data — to improve outcomes and speed up discovery.

HPE is also collaborating with France’s National Center for Scientific Research and GENCI to arm scientists at the Sorbonne University in Paris with GENCI’s Jean Zay supercomputer, which HPE designed. The team is using Jean Zay to optimize the Tinker-HP software, an approach to parallel computing enabled by multiple graphics cards and designed to simulate at the level of atoms for large biological molecules. Tinker-HP simultaneously performs a range of data-intensive calculations to create 3D simulations of molecular interactions faster and at high resolutions than would otherwise be possible.

Contributions from the private sector

The nature of the Consortium’s work isn’t strictly academic. Startups hope to use the group’s vast computational resources to develop treatments, molecular designs, and drugs targeting COVID-19.

Kolkata-based Novel Techsciences is identifying phytochemicals from the more than 3,000 medicinal plans and anti-viral plant extracts in India that might act as natural drugs against COVID-19. The team also plans to isolate plant-derived compounds that could help tackle multi-drug resistance that arises as the coronavirus mutates, with the goal of developing a comprehensive prophylactic treatment regime.

In London, Y Combinator-backed PostEr is overseeing the Moonshot Project, which aims to produce inhibitors based on over 60 fragment hits (i.e., molecules validated to bind to a target protein, making them a chemical starting point for drug discovery) that have been isolated in experiments to determine the molecular structure of COVID-19. By running machine learning algorithms in the background to triage suggestions and generate synthesis plans, PostEra has identified around 21 highly effective volunteer-submitted molecular designs, which will be synthesized by chemical company Enamine. The results of this project will be tested on animals in months.

If successful, PostEra’s would be one of the first drugs developed in an open source fashion. “[Machine learning] can reduce the time to determine optimal ways to make these compounds from weeks to days,” the company said in a statement. “[We believe] the worldwide scientific community [can suggest] drug candidates that might bind to, and neutralize, [COVID-19].”

Another private sector project is led by London-based AI startup Kuano. This team’s intention is to gain insights from diseases that are similar to COVID-19 — mainly other coronaviruses — to design an effective COVID-19 drug. This effort relies on a genetic algorithm that searches the chemical space surrounding existing antiviral drugs and a deep learning-based classification model built on existing binding data. The company is combining those tools with docking and molecular dynamics simulations to enhance the results and yield machine learning models that can be used to score molecular designs for synthesis as antiviral compounds.

As for AI and drug development startup Innoplexus, it’s also working with the Consortium’s supercomputers to accelerate the discovery of molecules that could lead to a drug to combat COVID-19. It expects to run permutations on five promising candidates — specifically, candidates that are potent, non-toxic, and can be manufactured.

Early days

Despite the fact that much of the work remains in the early stages, momentum around the Consortium appears to be accelerating.

Last month, IBM announced that UK Research and Innovation (UKRI) and the Swiss National Supercomputer Center (CSCS) will join the Consortium, making available machines that include the University of Edinburgh’s ARCHER; the Science and Technology Facilities Council’s DIRAC; the Biotechnology and Biological Sciences Research Council’s Earlham Institute; and Piz Daint, the sixth-ranked supercomputer in the world, according to the Top 500. The new additions have brought the total available petaflops up to 483 from 437 in May and 300 in mid-March.

“The COVID-19 HPC Consortium … is the largest public-private computing partnership ever created. What started as a series of phone calls […] five days later, more than two dozen partners came on board, many who are typically rivals,” said IBM’s Turek. “Without any large contracts or anything of the kind, this group [is coming] together in a way to both share resources and manage a process of expediting the scientific proposals that came into the consortia and match it to the best resources.”

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