#to under full general anaesthetic to get a fucking mole removed just get on with it

[somecunttookmyurl]

the liver thing isn't like a disease or a disorder or anything it's just genetic variance and can go either way. it's that guy who needs 2 paracetamol instead of 1, or that absolute bastard who only has to take half a pill

it becomes a Fucking Annoyance when you're far enough away from the bell curve that shit just doesn't work, or doesn't work enough to warrant taking. it is extra a Fucking Annoyance because you will go your whole life wondering why things simply don't affect you whilst doctors repeatedly either accuse you of lying because they don't know it can be a thing, or go through drug after drug after drug all metabolised the same way and which naturally don't work before giving up.

the fact it's considerably more common in people with chronic pain conditions (for reasons), and people with chronic pain being labelled drug seekers, are probably related.

the fact that ultra-rapid metabolisation on typically the most annoying pathway is most common in people from the middle east and... i think north africa? but very rare in white people (without chronic pain) is also for sure something ain't it (actually it's way more common in painless white people to go the other way and need less drugs. 7-10%. if you were wondering. you weren't)