#therapeuticstrategies

[shamistate]

Shamis Tate Talk Essential Guide to Therapies and Lifestyle Changes

"Shamis Tate Talk Essential Guide to Therapies and Lifestyle Changes" offers a comprehensive overview of effective therapeutic practices and lifestyle adjustments for optimal well-being. This guide delves into holistic healing techniques, practical lifestyle modifications, and evidence-based therapies, providing readers with actionable insights and strategies to enhance their health. Whether you're seeking mental clarity, physical vitality, or emotional balance, this essential guide equips you with the tools for transformative wellness.

[jamesscottbrownfoundation]

The Cinderella Phenomenon: An Overview

The recovery journey from selective abuse is intricate, requiring tailored therapeutic approaches to address the unique challenges and psychological impacts faced by survivors, highlighting the importance of understanding and resilience in the healing process.

Read more about Selective Abuse Survivors: Emerging Therapeutic Approaches for Healing and Growth. Visit the James Scott Brown Foundation for further insights.

[lovelypol]

"Strategic Insights into the Genomics Market: 2024-2033"

The genomics field is set for unprecedented growth and innovation from 2024 to 2033, transforming healthcare and numerous other sectors. Advances in CRISPR technology are driving gene editing breakthroughs, offering potential cures for genetic disorders and personalized medicine solutions. Whole genome sequencing is becoming more accessible and affordable, enabling comprehensive genetic profiling and precision healthcare. Integration with AI and big data analytics enhances our understanding of complex genetic interactions, leading to novel therapeutic strategies and preventive measures. Collaborative efforts between research institutions, biotech companies, and healthcare providers are accelerating the translation of genomic discoveries into practical applications.

#Genomics #CRISPR #GeneEditing #PrecisionMedicine #WholeGenomeSequencing #GeneticProfiling #AIInHealthcare #BigDataGenomics #HealthcareInnovation #BiotechRevolution #PersonalizedTherapies #GeneticDisorders #TherapeuticStrategies #PreventiveMedicine #BiomedicalResearch #HealthTech #FutureOfMedicine #GenomicResearch #TranslationalGenomics #NextGenHealthcare

[biomedres]

Journals on Medical Research

VEGF-Targeting Strategies against Diabetic Nephropathy: Obsolete or Still Promising? by Katsuyuki Tanabe in Biomedical Journal of Scientific & Technical Research (BJSTR) https://biomedres.us/fulltexts/BJSTR.MS.ID.000758.php

For more articles on biomedical open access journals please click here: https://biomedres.us/index.php

For bjstr journals

[healthtimetaylor]

18α-glycyrrhetinic acid ameliorates fructose-induced nephropathy.

PMID:  Biomed Pharmacother. 2020 May ;125:109702. Epub 2020 Feb 25. PMID: 32106383 Abstract Title:  18α-Glycyrrhetinic acid (GA) ameliorates fructose-induced nephropathy in mice by suppressing oxidative stress, dyslipidemia and inflammation. Abstract:  Excessive fructose (FRU) intake can result in insulin resistance and metabolic disorder, which are related to renal injury.18α-Glycyrrhetinic acid (GA) is a bioactive component mainly extracted from Glycyrrhiza radix, and has anti-oxidant and anti-inflammatory activities. However, its effects on FRU-induced renal injury still remain unclear. In this study, we found that 18α-GA treatments could significantly ameliorate the cell viability in FRU-treated tubule epithelial cells, accompanied with improved mitochondrial membrane potential. Furthermore, reactive oxygen species (ROS) accumulation in FRU-stimulated cells was markedly reduced by 18α-GA, which were associated with the activation of nuclear factor (erythroid-derived-2)-like 2 (Nrf-2) and the blockage of MAPKs signaling. Additionally, dyslipidemia detected in FRU-treated cells was greatly inhibited by 18α-GA. We also found that 18α-GA significantly ameliorated FRU-induced inflammation in cells through reducing the expression of pro-inflammatory cytokines and chemokine. The anti-inflammatory effects regulated by 18α-GA were mainly related to the repression of nuclear factor-κB(NF-κB) signaling. Furthermore, the protective effects of 18α-GA against ROS production, lipid accumulation and inflammation were verified in renal tissues from FRU-challenged mice, consequently improving metabolic disorder and kidney injury. Taken together, these findings demonstrated that 18α-GA exerted renal protective effects through reducing oxidative stress, lipid deposition and inflammatory response, and thus could be considered as a promising therapeuticstrategy for metabolic stress-induced kidney injury.

read more

[cancersfakianakis1]

LONG-TERM SURVIVAL IN PATIENTS RESPONDING TO ANTI-PD-1/PD-L1 THERAPY AND DISEASE OUTCOME UPON TREATMENT DISCONTINUATION

Purpose: Anti-PD-(L)1 can provide overall survival (OS) benefits over conventional treatments for patients with many different cancer types. However, the long-term outcome of cancer patients responding to these therapies remains unknown. This study is an exploratory study that aimed to describe the long-term survival of patients responding to anti-PD-(L)1 monotherapy across multiple cancer types. Experimental design: Data from patients treated with an anti-PD-(L)1 monotherapy in a phase 1 trial at Gustave Roussy were retrospectively analyzed over a period of 5 years. All cancer types (n=19) were included. Clinical and biological factors associated with response, long-term survival, and secondary refractory disease were studied. Results: Among 262 eligible patients, the overall objective response rate was 29%. The median progression-free survival of responder patients (RPs) at 3 months was 30 months, and the median OS of RP was not reached after a median follow-up of 34 months. In RPs, 3- and 5-year OS percentages were 84% and 64%, respectively.No death occurred in the 21 complete responders (CRs) during the overall follow-up. However, many partial responders (PRs) showed subsequent tumor relapses to treatment. Long responders (response 32 years) represented 11.8% of the overall population.These finding should be validated in further prospective studies. Conclusions:There are currently no differences in therapeuticstrategies between CRs and PRs to anti-PD-(L)1. We found a striking difference in OS between these two types of responses. Our results are in favor of evaluating patient stratifications strategies and intensification of treatments when tumor lesions of a partial responder to immunotherapy stop improving.

https://ift.tt/2C22fxn

[jobisite11]

Medical Strategy Lead, Therapeutic Strategy – Dermatology with Quintiles

The position listed below is not with North Carolina Interviews but with QuintilesNorth Carolina Interviews is a private organization that works in collaboration with government agencies to promote emerging careers. Our goal is to connect you with supportive resources to supplement your skills in order to attain your dream career. NorthCarolina Interviews has also partnered with industry leading consultants & training providers that can assist during your career transition. We look forward to helping you reach your career goals! If you any questions please visit our contact page to connect with us directlyThe role includes both Medical Monitoring responsibilities and Medical Strategic inputs. The function that should represent the primary focus will be communicated. Medical Monitoring:Primarily serves as Global Medical Advisor on assigned projects.Serves as Scientific Advisor and provides guidance to Project Leaders on the medical and scientific aspects of assigned projects.Provides medical support to investigative sites and project staff for protocol-related issues including protocol clarifications, inclusion/exclusion determinations, and issues of patient safety and/or eligibility.Performs medical review of the protocol, Investigative Drug Brochure (IDB), and/or Case Report Forms (CRFs).Provides therapeutic area/indication training for the project clinical team.Attends and presents at Investigator Meetings.Performs review and clarification of trial-related Adverse Events (AEs).May perform medical case review of Serious Adverse Events (SAEs), including review of case documentation and patient narrative, in collaboration with the Pharmacovigilance department.May provide medical support for the Analysis of Similar Events (AOSE), in collaboration with or on behalf of Pharmacovigilance department.May perform medical review of adverse event coding.Performs review of the Clinical Study Report (CSR) and patient narratives.Attends Kick-Off meetings, weekly team meetings, and client meetings, as needed or requested.Available 24 hours per day, 7 days per week to respond to urgent protocol-related issues at the investigative sites.Medical Strategy:Provides expert advises to the development of medically sounded delivery strategies for small to large and/or complex multi-region studies in partnership with sales and other functions responsible for business development activities.Responsible for the development of the medically related aspects of client proposals including the budget related to medical monitoring.Provides medical and scientific advises to key internal stakeholders developing proposals: this may include, but is not limited to, reviewing the protocol for scientific/regulatory soundness and feasibility, identification of target site and principal investigator profiles, anticipated patient recruitment, standard of care and competitive landscape.Attends and presents at bid defense meeting, as required.Participates in strategic business development activities including presentations to prospective clients.Maintains awareness of industry development and may author related publications.May serve as Regional/Multiregional/Global Therapeutic Lead for specific indication(s).Qualifications Medical degree from an accredited and internationally recognized medical school with a curriculum relevant to general medical education, along with a medical license, or equivalent, from the country or region in which he/she resides and works is required, plus a minimum of 5 years experience in clinical medicine, in addition to 4 - 8 years clinical trials experience as an investigator or in the Pharma, CRO, or Biotech industry. Specialty Board certification desirable; or equivalent combination of education, training and experience. Robust and current knowledge of scientific, clinical, regulatory, commercial and competitive landscape in applicable therapeutic area.Knowledge of applicable federal and local regulations and guidelines pertaining to clinical research.Strong communication, presentation and interpersonal skills, including good command of English language (both written and spoken).Business Acumen.Ability to establish and maintain effective working relationships with coworkers, managers and clients.Proven skills in providing consultation and advice on multiple assignments are required, as well as initiative and flexibility.May require regular travel.Extensive use of telephone and face-to-face communication requiring accurate perception of speech.Extensive use of keyboard requiring repetitive motion of fingers. Associated topics: ascp, blood collection, hematopathology, medical lab science, medical laboratory science, medical technologist, microbiology, mls, mlt, technician ii  MedicalStrategyLead,TherapeuticStrategy–DermatologywithQuintiles from Job Portal http://www.jobisite.com/extrJobView.htm?id=83317

[usajobsite]

Medical Strategy Lead, Therapeutic Strategy – Dermatology with Quintiles

The position listed below is not with North Carolina Interviews but with QuintilesNorth Carolina Interviews is a private organization that works in collaboration with government agencies to promote emerging careers. Our goal is to connect you with supportive resources to supplement your skills in order to attain your dream career. NorthCarolina Interviews has also partnered with industry leading consultants & training providers that can assist during your career transition. We look forward to helping you reach your career goals! If you any questions please visit our contact page to connect with us directlyThe role includes both Medical Monitoring responsibilities and Medical Strategic inputs. The function that should represent the primary focus will be communicated. Medical Monitoring:Primarily serves as Global Medical Advisor on assigned projects.Serves as Scientific Advisor and provides guidance to Project Leaders on the medical and scientific aspects of assigned projects.Provides medical support to investigative sites and project staff for protocol-related issues including protocol clarifications, inclusion/exclusion determinations, and issues of patient safety and/or eligibility.Performs medical review of the protocol, Investigative Drug Brochure (IDB), and/or Case Report Forms (CRFs).Provides therapeutic area/indication training for the project clinical team.Attends and presents at Investigator Meetings.Performs review and clarification of trial-related Adverse Events (AEs).May perform medical case review of Serious Adverse Events (SAEs), including review of case documentation and patient narrative, in collaboration with the Pharmacovigilance department.May provide medical support for the Analysis of Similar Events (AOSE), in collaboration with or on behalf of Pharmacovigilance department.May perform medical review of adverse event coding.Performs review of the Clinical Study Report (CSR) and patient narratives.Attends Kick-Off meetings, weekly team meetings, and client meetings, as needed or requested.Available 24 hours per day, 7 days per week to respond to urgent protocol-related issues at the investigative sites.Medical Strategy:Provides expert advises to the development of medically sounded delivery strategies for small to large and/or complex multi-region studies in partnership with sales and other functions responsible for business development activities.Responsible for the development of the medically related aspects of client proposals including the budget related to medical monitoring.Provides medical and scientific advises to key internal stakeholders developing proposals: this may include, but is not limited to, reviewing the protocol for scientific/regulatory soundness and feasibility, identification of target site and principal investigator profiles, anticipated patient recruitment, standard of care and competitive landscape.Attends and presents at bid defense meeting, as required.Participates in strategic business development activities including presentations to prospective clients.Maintains awareness of industry development and may author related publications.May serve as Regional/Multiregional/Global Therapeutic Lead for specific indication(s).Qualifications Medical degree from an accredited and internationally recognized medical school with a curriculum relevant to general medical education, along with a medical license, or equivalent, from the country or region in which he/she resides and works is required, plus a minimum of 5 years experience in clinical medicine, in addition to 4 - 8 years clinical trials experience as an investigator or in the Pharma, CRO, or Biotech industry. Specialty Board certification desirable; or equivalent combination of education, training and experience. Robust and current knowledge of scientific, clinical, regulatory, commercial and competitive landscape in applicable therapeutic area.Knowledge of applicable federal and local regulations and guidelines pertaining to clinical research.Strong communication, presentation and interpersonal skills, including good command of English language (both written and spoken).Business Acumen.Ability to establish and maintain effective working relationships with coworkers, managers and clients.Proven skills in providing consultation and advice on multiple assignments are required, as well as initiative and flexibility.May require regular travel.Extensive use of telephone and face-to-face communication requiring accurate perception of speech.Extensive use of keyboard requiring repetitive motion of fingers. Associated topics: ascp, blood collection, hematopathology, medical lab science, medical laboratory science, medical technologist, microbiology, mls, mlt, technician ii  MedicalStrategyLead,TherapeuticStrategy–DermatologywithQuintiles from Job Portal http://www.jobisite.com/extrJobView.htm?id=83317

[jobisitejobs]

Medical Strategy Lead, Therapeutic Strategy – Dermatology with Quintiles

The position listed below is not with North Carolina Interviews but with QuintilesNorth Carolina Interviews is a private organization that works in collaboration with government agencies to promote emerging careers. Our goal is to connect you with supportive resources to supplement your skills in order to attain your dream career. NorthCarolina Interviews has also partnered with industry leading consultants & training providers that can assist during your career transition. We look forward to helping you reach your career goals! If you any questions please visit our contact page to connect with us directlyThe role includes both Medical Monitoring responsibilities and Medical Strategic inputs. The function that should represent the primary focus will be communicated. Medical Monitoring:Primarily serves as Global Medical Advisor on assigned projects.Serves as Scientific Advisor and provides guidance to Project Leaders on the medical and scientific aspects of assigned projects.Provides medical support to investigative sites and project staff for protocol-related issues including protocol clarifications, inclusion/exclusion determinations, and issues of patient safety and/or eligibility.Performs medical review of the protocol, Investigative Drug Brochure (IDB), and/or Case Report Forms (CRFs).Provides therapeutic area/indication training for the project clinical team.Attends and presents at Investigator Meetings.Performs review and clarification of trial-related Adverse Events (AEs).May perform medical case review of Serious Adverse Events (SAEs), including review of case documentation and patient narrative, in collaboration with the Pharmacovigilance department.May provide medical support for the Analysis of Similar Events (AOSE), in collaboration with or on behalf of Pharmacovigilance department.May perform medical review of adverse event coding.Performs review of the Clinical Study Report (CSR) and patient narratives.Attends Kick-Off meetings, weekly team meetings, and client meetings, as needed or requested.Available 24 hours per day, 7 days per week to respond to urgent protocol-related issues at the investigative sites.Medical Strategy:Provides expert advises to the development of medically sounded delivery strategies for small to large and/or complex multi-region studies in partnership with sales and other functions responsible for business development activities.Responsible for the development of the medically related aspects of client proposals including the budget related to medical monitoring.Provides medical and scientific advises to key internal stakeholders developing proposals: this may include, but is not limited to, reviewing the protocol for scientific/regulatory soundness and feasibility, identification of target site and principal investigator profiles, anticipated patient recruitment, standard of care and competitive landscape.Attends and presents at bid defense meeting, as required.Participates in strategic business development activities including presentations to prospective clients.Maintains awareness of industry development and may author related publications.May serve as Regional/Multiregional/Global Therapeutic Lead for specific indication(s).Qualifications Medical degree from an accredited and internationally recognized medical school with a curriculum relevant to general medical education, along with a medical license, or equivalent, from the country or region in which he/she resides and works is required, plus a minimum of 5 years experience in clinical medicine, in addition to 4 - 8 years clinical trials experience as an investigator or in the Pharma, CRO, or Biotech industry. Specialty Board certification desirable; or equivalent combination of education, training and experience. Robust and current knowledge of scientific, clinical, regulatory, commercial and competitive landscape in applicable therapeutic area.Knowledge of applicable federal and local regulations and guidelines pertaining to clinical research.Strong communication, presentation and interpersonal skills, including good command of English language (both written and spoken).Business Acumen.Ability to establish and maintain effective working relationships with coworkers, managers and clients.Proven skills in providing consultation and advice on multiple assignments are required, as well as initiative and flexibility.May require regular travel.Extensive use of telephone and face-to-face communication requiring accurate perception of speech.Extensive use of keyboard requiring repetitive motion of fingers. Associated topics: ascp, blood collection, hematopathology, medical lab science, medical laboratory science, medical technologist, microbiology, mls, mlt, technician ii  MedicalStrategyLead,TherapeuticStrategy–DermatologywithQuintiles from Job Portal http://www.jobisite.com/extrJobView.htm?id=83317