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cimcondigital · 8 months ago

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How Digital Transformation aids the pharmaceutical industry

The pharmaceutical industry contributes significantly to developing vaccines and medications for disease prevention and reduction, treatment of ailments, and enhancement of quality of life by engaging in innovative research and technological advancements to meet the population’s complex healthcare demands.

India is the world’s top supplier of generic pharmaceuticals. The Indian pharmaceutical industry meets more than half of the global demand for various vaccines, 40% of generic demand in the United States, and 25% of total medicine in the United Kingdom. Globally, India ranks third in pharmaceutical manufacturing by volume and fourteenth in value. The domestic pharmaceutical sector comprises 3,000 pharmaceutical businesses and 10,500 manufacturing units. India holds a significant place in the global pharmaceutical industry. The country also possesses a vast pool of scientists and engineers who can propel the industry forward. More than 80% of antiretroviral medications used to combat AIDS are manufactured in the United States.

The typical human lifespan is exposed to more infections and diseases, necessitating preventative measures to maintain health and more significant research to improve the population’s quality of life. Hectic daily schedules, lack of exercise and sleep, improper eating habits, and other lifestyle choices have contributed to poor digestion, high obesity rates, breathing difficulties, and other health issues. Globalization and urbanization are important influences driving the increasing demand for health supplements and better pharmaceuticals. As chronic ailments have increased, people have become more reliant on health supplements and drugs.

With the covid 19, major disruptions have occurred in the Pharma industry. Some of the common challenges in the Pharma industry include

Difficulties in removing organizational silos which prevents Pharma companies from embracing the full potential of digital transformation

Lack of clarity in the current regulations regarding the use of technology

The Digital Transformation strategy prepared by the Pharma companies post covid is not founded on real knowledge of how to maximise business benefits.

With Digital Transformation in place there have been some massive upgradations that has happened in the past few years in the Pharma industry as well

Artificial Intelligence: Artificial intelligence (AI) is speeding up drug discovery and development processes. Startups are investigating the application of these technologies to address numerous difficulties in the pharmaceutical sector, such as manufacturing process automation and optimization, as well as devising efficient marketing and post-launch tactics. Patient identification is essential in drug discovery and development, mainly when performing clinical trials. AI simplifies the identification of eligibility criteria and patient inclusion, making the cohort identification process faster and less expensive.

Big Data and Analytics: The pharmaceutical industry requires high-performance systems to analyse the massive amounts of data created during the drug discovery and development process. Pharmaceutical firms rely on third-party vendors to share data with collaborators, making data management a critical priority. Analytical techniques advancements are also transforming historical and real-time data available to pharmaceutical businesses into valuable assets for predictive, diagnostic, prescriptive, and descriptive analytics.

Flexible Production: Because of shifting market dynamics, the pharmaceutical industry is experimenting with innovative manufacturing methods, such as small batches for precision medicine. Single-use bioreactors are also gaining popularity due to their ability to reduce downtime and boost productivity. These bioreactors accomplish this by removing complex tasks like cleaning and validation between production rounds.

Curative therapies: Curative medicines, such as cell and gene therapies, transform how we treat chronic diseases and difficult-to-treat ailments by removing the need for long-term medications. Gene therapy is introducing genetic material into cells to compensate for defective genes or produce a good protein. The most frequent vectors for gene therapy are genetically modified viruses.

CIMCON Digital pioneers in predictive and prescriptive maintenance of machines and enable industries to have an edge over the competition in the Pharmaceutical industry. With the state-of-the-art Vibration systems and Edge platforms, CIMCON Digital helps in the digital transformation of the Pharma industry with proper maintenance of assets and reduce the unplanned downtime. Supply chain being one of the major issues in Pharma industries, CIMCON Digital make sure that the supply chain works uninterrupted with no major unplanned shutdowns and the Pharma industries can work in better production of items.

Pharma industries will have to adopt Digital Transformation in the coming years in order to improve the supply chain and for better competing with other players in the world globally. Leveraging the technology like predictive maintenance, predictive maintenance, AI/ML, Edge technology will allow pharmaceutical companies to harness Digital Transformation successfully, optimise their processes and deliver the solutions to their patients in a more efficient manner.

#pharmaceutical industry #Digital Transformation

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ecovolve · 4 years ago

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BEST HALAL SUPPLEMENT

WHAT IS GINGER?

Ginger is a plant with verdant halal supplements stems and yellowish green blossoms. The ginger zest comes from the underlying foundations of the plant. Ginger is local to hotter pieces of UK, Asia, like China, Japan, and India, yet now is filled in pieces of South American and Africa. It is halal supplements likewise now filled in the Middle East to use as medication and with food.

Ginger is generally used to treat different sorts of "stomach issues," including movement disorder, morning infection, colic, halal supplements steamed stomach, gas, the runs, peevish entrail condition (IBS), queasiness, sickness brought about by malignant growth therapy, queasiness brought about by HIV/AIDS therapy, halal supplements queasiness and spewing after a medical procedure, just as loss of hunger.

Different utilizations incorporate help with discomfort from rheumatoid joint inflammation (RA), osteoarthritis, feminine agony, upper respiratory plot diseases, hack, respiratory issues, headache cerebral pain, bronchitis, and diabetes. Ginger is additionally halal supplements some of the time utilized for chest torment, low back agony, and stomach torment, stopping utilization of medications called specific serotonin reuptake inhibitors (SSRIs), anorexia, to invigorate bosom milk, as a diuretic, and to build perspiring. It is halal supplements likewise used to treat cholera, dying, bacterial wicked looseness of the bowels, hair loss, intestinal sickness, aroused balls, harmful snake chomps, and toothaches.

A few group pour the new squeeze on their skin to treat consumes. The halal supplements oil produced using ginger is now and then applied to the skin to mitigate torment. Ginger concentrate is additionally applied to the skin to forestall bug chomps.

In food sources and drinks, ginger is utilized as an enhancing specialist.

In assembling, ginger is utilized with respect to scent in cleansers and beautifying agents.

One of the synthetics in ginger is additionally utilized as a fixing in diuretic, enemies of gas, and acid neutralizer prescriptions.

Super Tips to Boost Digestive Health: Bloating, Constipation, and that's just the beginning

IS GINGER EFFECTIVE?

There is some logical proof that ginger can forestall halal supplements movement affliction and nausea.

Ginger may likewise help forestall morning disorder, yet it ought not be utilized for this reason. The wellbeing of ginger halal supplements in pregnancy has not been demonstrated.

There is likewise proof that ginger can ease joint agony and help development in individuals who have rheumatoid joint inflammation. However, halal supplements ginger doesn't appear to be useful for individuals with another sort of joint inflammation called osteoarthritis.

There isn't sufficient data to know whether ginger is powerful for different conditions individuals use it for including: steamed stomach, loss of hunger, colds, influenza, and others.

Potentially EFFECTIVE FOR...

Sickness and heaving brought about by HIV/AIDS therapy. Exploration recommends that requiring ginger every day, 30 minutes before halal supplements each portion of antiretroviral treatment for 14 days, diminishes the danger of queasiness and retching in patients accepting HIV treatment.

Difficult feminine periods. Examination shows that taking ginger powder 500-2000 mg during the initial 3-4 days of a feminine cycle unobtrusively diminishes torment in ladies with excruciating feminine periods. Some particular dosages that have been utilized incorporate 500 mg of ginger multiple times every day and a particular ginger concentrate (Zintoma, Goldaru) 250 mg halal supplements multiple times day by day. Portions were allowed for 3 days beginning toward the start of the feminine time frame. The particular ginger concentrate (Zintoma) appears to work probably just as the prescriptions ibuprofen or mefenamic corrosive.

Morning disorder. Taking ginger by mouth appears to diminish sickness and regurgitating in some pregnant ladies. In any case, it may work more slow or not just as certain medications utilized for sickness. Likewise, halal supplements taking any spice or prescription during pregnancy is a critical choice. Prior to taking ginger, make certain to examine the potential dangers with your medical care supplier.

Osteoarthritis. Some exploration shows that taking ginger can unobtrusively lessen torment in certain individuals with a type of joint inflammation called "osteoarthritis." One investigation shows that taking 250 mg of a particular ginger concentrate (Zintona EC) multiple times day by halal supplements day decreases joint pain torment in the knee following 3 months of treatment. Another examination shows that utilizing an alternate ginger concentrate (Eurovita Extract 77; EV ext-77), which consolidates a ginger with alpinia, likewise lessens torment after standing, torment subsequent to strolling, and firmness. Some examination has contrasted ginger with drugs like ibuprofen. In one investigation, a particular ginger concentrate (Eurovita Extract 33; EV ext-33) didn't decrease joint inflammation torment just as taking 400 mg of ibuprofen multiple times every day. However, in another investigation, taking 500 mg of ginger concentrate twice every day worked probably just as halal supplements 400 mg of ibuprofen multiple times day by day for hip and knee torment identified with joint inflammation. In another examination, a particular ginger concentrate joined with glucosamine (Zinaxin glucosamine, EV ext-35) filled in just as the mitigating drug diclofenac moderate delivery (100 mg every day) in addition to glucosamine sulfate (1 gram day by day). Exploration likewise recommends that knead treatment utilizing an oil containing ginger and orange appears to decrease transient solidness and agony in individuals with knee torment.

Sickness and heaving following a medical procedure. Most clinical examination shows that taking 1 to 1.5 gram of ginger one hour before medical procedure appears to decrease queasiness and regurgitating during the initial 24 hours after medical procedure. One examination discovered ginger halal supplements decreased sickness and spewing by 38%. Additionally, applying 5% ginger oil to patients' wrists before medical procedure appears to forestall queasiness in about 80% of patients. Nonetheless, taking ginger by mouth probably won't diminish queasiness and regurgitating in the period 3-6 hours after medical procedure. Additionally, ginger probably won't have added substance impacts when utilized with prescriptions for queasiness and spewing. Furthermore, halal supplements ginger probably won't bring down the danger of sickness and spewing after a medical procedure in individuals who have an okay for this occasion.

Unsteadiness (dizziness). Taking ginger appears to lessen the indications of dazedness, including queasiness .

Conceivably INEFFECTIVE FOR...

Forestalling movement infection and nausea. Most exploration proposes that taking ginger as long as 4 hours before movement doesn't forestall movement ailment. A few group report feeling good, however genuine estimations taken during contemplates propose something else. Yet, in one halal supplements examination, ginger gives off an impression of being more successful than the medication dimenhydrinate at lessening stomach upset related with movement infection.

Deficient EVIDENCE TO RATE EFFECTIVENESS FOR...

Abrupt respiratory framework disappointment (Acute respiratory pain condition). Exploration proposes that controlling 120 mg of ginger concentrate day by day for as long as 21 days expands the quantity of days without ventilator support, the measure of supplements devoured, and diminishes the time spent in escalated care units in individuals with abrupt halal supplements respiratory framework a disappointment. In any case, ginger concentrate doesn't appear to influence demise rates in individuals with this condition.

Queasiness and spewing because of chemotherapy. There is conflicting proof about the viability of ginger for queasiness and retching brought about by chemotherapy for disease. Some proof recommends that taking ginger by mouth may help diminish sickness brought about by chemotherapy. Nonetheless, other proof recommends that adding ginger is not any halal supplements more powerful than standard enemy of queasiness medicines alone. Purposes behind the clashing outcomes might be the sort and portion of ginger utilized, just as the time at which ginger treatment was begun.

Ongoing obstructive pneumonic illness (COPD). Exploration shows that taking two cases of a particular mix item (AKL1, AKL International Ltd) containing ginger twice day by day for about two months doesn't improve halal supplements respiratory indications in individuals with COPD.

Diabetes. There is conflicting proof about the impacts of ginger on glucose control in individuals with diabetes. Some examination recommends that taking ginger day by day in two isolated dosages for about halal supplements two months diminishes insulin levels, however not glucose. Another investigation shows that ginger influences glucose, however not insulin levels. Despite the fact that it's not satisfactory, the clashing outcomes might be because of the portion of ginger utilized or the timeframe the patients had been determined to have diabetes.

Resentful stomach (dyspepsia). Examination proposes that taking a solitary portion of 1.2 grams of ginger root powder one halal supplements hour prior to gobbling speeds up how rapidly food discharges out of the some in individuals with dyspepsia.

Liquor aftereffect. Early examination proposes that taking a blend of ginger, substance of Citrus tangerine, and earthy colored sugar prior to drinking diminishes indications of liquor aftereffects, including sickness, spewing, and the runs. Visit below to get best halal supplement! https://halalsupplement.net/ https://halalsupplement.net/ https://halalsupplement.net/

Elevated cholesterol. Examination proposes that taking 1 gram of ginger multiple times day by day for 45 days brings down fatty substance halal supplements and cholesterol levels in individuals with elevated cholesterol.

Creepy crawly chomps. Early exploration propose that applying Trikatu to the skin, which contains ginger, long pepper, and dark pepper separates, doesn't diminish mosquito reduced down.

Touchy inside disorder (IBS). There is conflicting proof about the impacts of ginger on IBS manifestations. Some examination proposes that taking ginger day by day for 28 days doesn't improve indications. In any case, other examination proposes that utilizing a natural combination containing English horsemint, purple nut sedge tuber, and halal supplements ginger tuber multiple times day by day for about two months is pretty much as powerful as the medication bebeerine at lessening IBS manifestations. However, it's not satisfactory if ginger or different fixings advance manifestation help.

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sunnyoharma · 4 years ago

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Harvoni combines ledipasvir, an HCV NS5A inhibitor, and sofosbuvir, an HCV NS5B polymerase inhibitor. It could cause your hepatitis C virus more durable to treatment with anti-viral medicines . If you could have a hepatitis B infection, using sofosbuvir and velpatasvir may trigger the virus to become more lively and won't assist your EPCLUSA remedy at all or it could cause demise. Test all sufferers for proof of current or prior hepatitis B virus infection before initiating remedy with sofosbuvir / velpatasvir. HBV reactivation has been reported in HCV/HBV coinfected patients who have been undergoing or had accomplished therapy with HCV direct appearing antivirals and weren't receiving HBV antiviral therapy. Some circumstances have resulted in fulminant hepatitis, hepatic failure, and death. mavyret generic

Founded in 2018, Asegua Therapeutics LLC is committed to providing larger access to therapies. Asegua Therapeutics LLC has launched a licensed generic of EPCLUSA® (sofosbuvir/velpatasvir) and an authorized generic of HARVONI® (ledipasvir/sofosbuvir). There are not any enough, nicely-managed studies in pregnant women who've taken Epclusa without ribavirin. Epclusa must be used during being pregnant only if the potential benefit justifies the potential danger to the fetus.

Monitor HCV/HBV coinfected patients for hepatitis flare or HBV reactivation during HCV therapy and submit-remedy comply with-up. Initiate acceptable affected person administration for HBV an infection as clinically indicated. Similar data had been used to assist dosing recommendations for pediatric topics with HCV genotype 1, 2, 3, 4, 5 or 6 an infection who have extreme cirrhosis. Sofosbuvir/velpatasvir in combination with ribavirin is indicated for the therapy of kids six years and older or weighing a minimum of 37 kilos with severe cirrhosis. Sofosbuvir/velpatasvir, bought under the model name Epclusa among others, is a hard and fast-dose mixture medication for the treatment of hepatitis C in adults. It is greater than 90% effective for hepatitis C genotypes one via six. It also works for hepatitis C in those who even have cirrhosis or HIV/AIDS.

Tell your doctor about all your present medicines and any drugs you start or stop utilizing. If you have ever had hepatitis B, utilizing sofosbuvir and velpatasvir may cause this virus to become active or get worse. You might have frequent liver operate checks while using this medicine and for a number of months after you stop. In one aspect, the method contains administering to the topic an interferon-free therapy routine comprising an effective amount of GS-7977 and an efficient quantity of ribavirin. In a specific aspect, the method is sufficient to provide an undetectable quantity of HCV RNA in the topic for at least 12 weeks after the tip of the time interval. During pregnancy, this medication ought to be used solely when clearly needed. Sofosbuvir/velpatasvir, together with ribavirin, must not be used during being pregnant by both the pregnant lady or her male associate.

A licensed pharmacist is aware of how so you better ask for advice from them on the way to properly dispose of EPCLUSA. If vomiting happens within 3 hrs after taking EPCLUSA, take one other dose. If it is already longer than 3 hrs since you could have taken the first one, then don't take another pill of EPCLUSA. Just proceed with the conventional dosage and circulate of your therapy. In case you are taking Ribavirin additionally whereas under EPCLUSA prescription, then there is a treatment guide you should follow from your well being professional, and that includes how many doses you ought to be taking. The data offered in this web site is for educational purposes and not meant to exchange a discussion or recommendation with a healthcare supplier.

Common unwanted side effects embrace complications, feeling drained, bother sleeping, and nausea. It has not been studied in pregnant ladies or during breastfeeding. Greater care is required in those who are also infected with hepatitis B. Sofosbuvir works by blocking the NS5B protein and velpatasvir works by blocking the NS5A protein. One tablet as soon as day by day, often for 12 weeks, with or without food.

Read the Patient Information Leaflet if obtainable from your pharmacist before you begin taking sofosbuvir/velpatasvir and every time you get a refill. It isn't known if this remedy can stop you from passing the virus to others. Do not share needles, and apply "safer sex" to lower the risk of passing the virus to others. “We count on to see a positive impression on sharing Medicaid markets during the second half of 2019. One means Gilead's doing that's through state-managed Medicaid plans. When Gilead first unveiled the generics initiative, Evercore ISI analyst Umer Raffat famous the corporate’s presence in Medicaid was very low, as Mavyret takes the lion’s share.

In patients with serologic evidence of HBV an infection, monitor for scientific and laboratory signs of hepatitis flare or HBV reactivation during HCV remedy with EPCLUSA and through publish-treatment comply with-up. Hepatitis B virus reactivation has been reported in HCV/HBV coinfected patients who have been undergoing or had completed treatment with HCV direct appearing antivirals, and who weren't receiving HBV antiviral remedy. Cases have been reported in patients who're HBsAg positive and in addition in sufferers with serologic evidence of resolved HBV infection (i.e., HBsAg negative and anti-HBc constructive). HBV reactivation has also been reported in patients receiving sure immunosuppressants or chemotherapeutic agents; the danger of HBV reactivation associated with therapy with HCV direct-acting antivirals may be elevated in these patients. Increases in indirect bilirubin up to three mg/dL above baseline have been noted among HIV-1/HCV coinfected subjects handled with EPCLUSA and an atazanavir/ritonavir-primarily based antiretroviral regimen. The elevated indirect bilirubin values weren't associated with scientific antagonistic occasions, and all topics completed 12 weeks of EPCLUSA without dose adjustment or remedy interruption of both EPCLUSA or HIV antiretroviral agents. In the Phase three trial with decompensated cirrhosis (ASTRAL-four), isolated, asymptomatic creatine kinase elevations larger than or equal to 10xULN were reported in 1% of subjects treated with EPCLUSA with ribavirin for 12 weeks.

LEDIPASVIR/SOFOSBUVIR is a prescription medicine used to treat adults with chronic hepatitis C genotype 1, four, 5 or 6 infection with or with out cirrhosis . In these with GT 1 and superior cirrhosis or with GT 1 or four with or with out cirrhosis who've had a liver transplant, LEDIPASVIR/SOFOSBUVIR is used with ribavirin. SOFOSBUVIR/VELPATASVIR is a prescription drugs used to deal with adults with chronic hepatitis C genotype 1, 2, 3, four, 5, or 6 infection with or with out cirrhosis . In these with superior cirrhosis , SOFOSBUVIR/VELPATASVIR is used with ribavirin.

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medbuzz · 3 years ago

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Reasons Why India is the "Pharmacy" of the Developing World

www.medbuzz.in

Reasons Why India is the "Pharmacy" of the Developing World

India, a developing country, faces several challenges, especially providing its citizens with affordable medicines of high quality. It is not only the case with India but with every developing nation around the world. India's tag in medicine reminds the world of two things, high quality, and low price. The combination and ensuring health security in several developing countries makes Indian medicines favorite among the developing countries. India is one of the largest pharmaceuticals producers worldwide and has the largest United States Food and Drug Administration plants outside the US. The country's pharmaceutical industry is known for its competitiveness because of the ability to master the production of niche medicines quickly, strong R&D backup, competitive domestic firms, and Active Pharmaceutical Ingredient. "Robinhood"- is the name given to India in the world of pharmaceuticals.

Some reasons why India is the "Pharmacy: of the Developing World

1. India's affordable medicines make millions of people worldwide to stay alive

India, before 2005 did not grant product patents on medications, which allowed for the production of low-cost medicines with generic names protected with patents in other countries. Indian generic manufacturers were the first to market low-cost medicines with generic names of the life-saving HIV medicines (Zidovudine) and cancer (Imatinib) through reverse engineering skills within a few years of their US launch. There was a price reduction of more than 99 percent of medicines like HIV/AIDS, Hepatitis C, Tuberculosis, Malaria, and medicines for non-communicable diseases because of robust competition among generic producers in India.

2. Access to affordable HIV medication from India is one of the most exceptional success stories in medicine is

Africa was the worst-hit country because of AIDS in 1999. Big pharmaceutical companies were charging over $10,000 per month per patient every year for the antiretrovirals because of patent monopolies that made treatment economically unviable for millions of patients in the developing world.

Cipla, a generic medical company, announced that it would manufacture and supply the HIV antiretrovirals at $1 per day, a 99.99 percent price cut. At present, India is the primary source of affordable HIV medicines globally, as it is one of the few countries to produce newer HIV medicines with generic names much faster than any other country in the world.

3. One of the most influential suppliers of low-cost vaccines in the world is India

An excellent example of India's low-cost medicines with generic names is the recombinant Hepatitis B vaccine. Large multinational pharmaceutical companies ensured that the medicine price was high and held a monopoly on the vaccine. A manufacturer in India saw a gap of need at $23 per dose and developed a Hepatitis B vaccines to reduce the medicine price to less than $1 per dose in the absence of patent barriers. India, today is the leading supplier of vaccines to the Ministers of Health in numerous countries and UNICEF.

4. India makes affordable generics possible and prevents 'evergreening.'

In 2005, while allowing patent protection for new pharmaceutical compounds, India adopted a strict medicines patent law, which made it tougher to get a patent on new forms of existing medicines.

The law was designed, keeping in mind the objective of stopping medicine giants from indulging in 'evergreening' an unfortunately common and abusive patenting practice in the pharmaceutical industry. It is also aimed at filing and then obtaining separate patents referred to as secondary patents relating to different medical aspects. These patents are routinely granted in the US and other countries, but India chose to give medication importance to the pharmaceutical industry's business interest. Thus, imatinib mesylate, the generic medicine in India, costs $790 per patient, which costs $106,322 in the US.

5. Low-cost Indian generics vs. sky-high prices of patented drugs in the US

Since US laws and policies blindly favor pharmaceutical companies over medicines with generic names, the US prices are the highest in the world. Thus, this allows multiple and extended monopolies on the same medicine to increase costs for a more extended period.

To reduce medicine prices in India, the policy and lawmakers have identified generic competition as the most effective and most robust way. In India, affordable medicines for people and governments in developing countries result from fewer pharmaceutical companies' patents.

Conclusion

The healthcare system's main motive is pushing countries moving towards public health, ensuring that medicines are easily accessible and available for the largest number of people possible. Still, there are places where people need to pay for their medication out of their pocket, and major developing countries take the top list in spending the larger percentage on health. So if the medicines with generic names get shut down, it is a matter think what would be the situation with just branded versions.

Medecins sans Frontieres calls India 'the pharmacy of the developing world.' Because of the reasons mentioned above and mostly due to the fastest development of medicines with generic names, India was honored with 'the pharmacy of the developing country.' Indian Government has launched various generic medical stores in India that aids even the poor sections of the country to avail and access life-saving medicines without compromising quality and standards.

At Medbuzz, we are an online generic medicine website and generic medicine app that provides cost effective and easy to home delivery services for people who want to buy generic medicines. If you choose to buy generic medicines online or otherwise, at Medbuzz, we can help you cut down your medical bills by over 70%. Do place your order on our online generic medicine website or our generic medicine app that is available for download on both iOS and Android.

#pharmacy app #online pharmacy India #best online pharmacy #generic pharmacy India

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azistacontent · 1 year ago

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#ABACAVIR AND LAMIVUDINE TABLETS #Abacavir (600mg)#Lamivudine (300mg)#Abacavir #Lamivudine Tablets Exporters #Bulk Supplier of Abacavir #Lamivudine Tablets in India #exporters of hiv medicines #suppliers of antiretroviral medicines

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livealthbiopharma · 1 year ago

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Livealth Biopharma Pvt Ltd is the leading manufacturer and supplier of generic medical drugs and medicines across India.

#generic medical drugs manufacturer india #generic medicinal products supplier india #antidote drugs supplier india #contrast media suppliers india #anti malarial drugs manufacturers in india #pharmaceutical tablets manufacturers #antiretroviral drug manufacturers #lidocaine hcl #diltiazem tablets #Injectable Products Manufacturers in Mumbai #Anti Viral Drugs Suppliers in India #Antibiotic Tablets #daptomycin for injection #carvedilol tablets

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lovemiraclehunter-blog · 6 years ago

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Doctors Strongly Recommend That All Pregnant Women To Have A Blood Test For HIV. A indulge born two-and-a-half years ago in Mississippi with HIV is the fundamental dispute of a so-called "functional cure" of the infection, researchers announced Sunday. Standard tests can no longer learn of any traces of the AIDS-causing virus even though the child has discontinued HIV medication. "We into this is the first well-documented case of a functional cure," said studio lead author Dr Deborah Persaud, associate professor of pediatrics in the strife of infectious diseases at Johns Hopkins Children's Center in Baltimore active ingredients in bobaraba cream. The finding was presented Sunday at the Conference on Retroviruses and Opportunistic Infections, in Atlanta. The little one was not part of a study but, instead, the beneficiary of an unexpected and partly unplanned cycle of events that - once confirmed and replicated in a unbending study - might help more children who are born with HIV or who at risk of contracting HIV from their spoil eradicate the virus from their body. Normally, mothers infected with HIV take antiretroviral drugs that can almost reject the odds of the virus being transferred to the baby girls. If a mother doesn't recognize her HIV status or hasn't been treated for other reasons, the baby is given "prophylactic" drugs at birth while awaiting the results of tests to fix on his or her HIV status. This can take four to six weeks to complete. If the tests are positive, the tot starts HIV drug treatment inova healthsource merrifield. The mum of the baby born in Mississippi didn't know she was HIV-positive until the time of delivery. But in this case, both the opening and confirmatory tests on the baby were able to be completed within one day, allowing the baby to be started on HIV panacea treatment within the first 30 hours of life. "Most of our kids don't get picked up that early". As expected, the baby's "viral load" - detectable levels of HIV - decreased progressively until it was no longer detectable at 29 days of age. Theoretically, this foetus (doctors aren't disclosing the gender) would have enchanted the medications for the unwind of his or her life, said the researchers, who included doctors from the University of Massachusetts Medical School and the University of Mississippi Medical Center. Instead, the youngster stayed on the regimen for only 18 months before dropping out of the medical set and discontinuing the drugs. Ten months after stopping treatment, however, the son was again seen by doctors who were surprised to find no HIV virus or HIV antibodies with approved tests. Ultrasensitive tests did detect infinitesimal traces of viral DNA and RNA in the blood. But the virus was not replicating - a strongly unusual occurrence given that drugs were no longer being administered, the researchers said. No one is truly sure why this child achieved a "functional" remedy - meaning the virus is in remission even without medications. But investigators believe that giving antiviral curing so early in life meant the virus had no time to create viral "reservoirs" where dormant HIV cells can procrastinate for years before becoming active again. "For us this is a very exciting finding. By treating a newborn very early we may be able to prevent viral reservoirs or cells that stay around for a lifetime of an infected person". But Dr Michael Horberg, stool of the HIV Medicine Association and director of HIV/AIDS at Kaiser Permanente, stressed that this was a "functional medicine and not a cure in the most classic sense of the word. If we lift adults off HIV medications, they almost certainly within a short time period would have levels of virus back to where they were before they were taking medication". Only one example of a "sterilizing cure" - when there are absolutely no traces of HIV in the body - has been documented. This occurred in the alleged "Berlin patient," who received a bone marrow transplant for leukemia. The transplanted cells came from a supplier who had a rare genetic mutation that increases immunity against the most common state of HIV. The Berlin patient has remained HIV-free after discontinuing drug therapy. And Persaud said she is not advocating that the Mississippi crate become the standard of care. "This is a single case and we don't unusually know what are all of the factors involved ". But the case does "pave the way now for us to in a wink start clinical studies to see if we can replicate these findings in more infants". Those trials are apt to move forward. At the last follow-up, the child born in Mississippi was "doing well and was healthy". Horberg said the findings in the coddle were "encouraging" but "time will tell" if such a strategy can keep the virus under rule for long periods of time without medication. He emphasized that there are ways to prevent a baby from becoming infected in the first off place. "This again shows the importance of testing pregnant mothers and getting them into care and on treat treatment such that we wouldn't even need to worry about it at this point. What's encouraging, though, if it does come to this point, we might have some capital treatment options" malebox.us. The research presented Sunday was funded by the US National Institutes of Health and the American Foundation for AIDS Research.

#virus #tests #mississippi #treatment #drugs #functional #viral

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healingpharma · 3 years ago

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TENOFOVIR MANUFACTURER

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WHAT IS TENOHEAL (TENOFOVIR) ?

Tenoheal (Tenofovir disoproxil fumarate) is an antiretroviral medication that is used in combination with other antiretroviral drugs to treat HIV infection. Tenoheal is also prescribed for the treatment of chronic hepatitis B.

SIDE-EFFECTS

depression

dizziness

diarrhea

nausea

insomnia

headache

stomach ache

Tenofovir has an influence on your immune system, which can result in adverse effects weeks or months after you've taken it.

Tenoheal is an HIV medication that is taken in conjunction with other HIV medications to help manage the virus. It helps your immune system work more effectively by reducing the amount of HIV in your body. This lowers your risk of HIV-related complications (including new infections and cancer), while also increasing your quality of life. Tenofovir belongs to the class of drugs known as nucleotide reverse transcriptase inhibitors (NRTIs).

Tenofovir is not an antiretroviral medicine for the treatment of HIV infection. Make every effort to limit your chances of infecting HIV-positive people: Continue taking your HIV meds as prescribed by your doctor, (2) use an effective barrier technique (latex or polyurethane condoms/dental dams) during all sexual activity, and (3) do not exchange needles/syringes, toothbrushes, or razors that have come into contact with blood or other body fluids. Consult your physician for additional information.

Tenofovir is also used to treat a kind of liver infection known as chronic hepatitis B. It helps to reduce the amount of hepatitis B virus in your body by interfering with virus growth.

Healing Pharma operates in Brazil, Cambodia, Venezuela, the Philippines, Nigeria, Seychelles, and Sudan as a Tenofovir Manufacturer and Tenofovir supplier. Tenofovir Disoproxil Fumarate Tablets IP 300mg (Tenofovir Disoproxil Fumarate Tablets IP 300mg) is a drug that is used to treat HIV infection.

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topbestsexologistindelhi · 3 years ago

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How long is PEP treatment?

PEP (post-exposure prophylaxis) is a short course of antiretroviral drugs given soon after a possible HIV infection to prevent the virus from taking hold in your body.

It must be started within 72 hours (3 days) of an HIV exposure in order to be effective. Every minute counts!

Only in the most dire of circumstances should PEP be used. It is not intended for usage by persons who may be exposed to it

Energy might be appropriate for you in the event that you are HIV-negative or don't have the foggiest idea about your HIV status, and you figure you may have been presented to HIV as of now:

During sex (for instance, you had a condom break with an accomplice of obscure HIV status or a cooperate with a not virally stifled) HIV)

Through shared needles, needles, or other hardware used to infuse drugs, or

Through rape

Contact your medical care supplier quickly or go to a trauma center or critical consideration facility immediately.

Your medical care supplier or trauma center specialist will assess you, assist you with choosing whether PEP is ideal for you, and work with you to figure out which drugs to take for PEP.

Also, in the event that you are a medical services laborer, you might be recommended PEP after a potential openness to HIV at work, for example, from a needlestick injury.

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joinhubpharma · 4 years ago

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Five reasons why India is the drugstore to the sector

Agrarian countries over the world face a couple of challenges, key among which is offering their family viable drugs of high-type.

A 'public first' approach to manage technique, serious prescription patent law, and specialists who have utilized sorting out to introduce regular meds, are a bit of the reason that India has climbed as the 'drug store' of the world'. Scrutinize on to discover extra.

A considerable number of people far and wide rely upon sensible medications made in India to stay alive, making the nation the 'drug store' of the world

Prior to 2005, India didn't allow thing licenses on drugs. This is considered for the production of insignificant exertion, nonexclusive types of drugs that were authorized in various countries.

With their sorting out aptitudes, Indian drug manufacturers makers were the first to advance insignificant exertion interpretations of the HIV drugs (Zidovudine) and life-saving danger (Imatinib) inside quite a long while of their US dispatch. Solid contention among customary makers in India has accomplished a cost lessening of over 99% for drugs across various therapeutic areas, including HIV/AIDS, Malaria, Hepatitis C, Tuberculosis, and solutions for non-communicable ailments that are fundamental for general prosperity programs.

India is presumably the greatest supplier of straightforwardness antibodies on the planet

The recombinant Hepatitis B vaccination is an incomprehensible instance of one of India's straightforward solutions. Tremendous worldwide medication associations held a totally forcing plan of action on the neutralizer and guaranteed that the cost of the medication was high. At $23 per divide, a medicine maker in India saw a disregarded need and, without patent limits, developed a Hepatitis B counteracting agent to lessen the cost of the drug to under $1 per partition. Today, India is a fundamental supplier of antibodies to UNICEF and to the Ministries of Health in various countries.

Permission to direct HIV treatment from India is remarkable among different instances of defeating affliction in medicine

In the year 1999, WHO broadcasted that HIV/AIDS was the No.1 killer in Africa. Enormous medication relationships with patent impressive plans of action were costing more than $10,000 per open-minded each year for antiretrovirals (HIV meds), suitably making treatment financially sensible for countless patients on the planet.

JoinHub Pharma manufactures and supplies the triple fixed-partition mix of HIV antiretrovirals at a humble rate, a 99.99% worth cut.

Today, India is the world's major wellspring of sensible HIV prescriptions as it is one of just a small bunch scarcely any countries with the ability to quickly convey more forward-thinking HIV drugs as generics.

Organizations of numerous horticultural countries have additionally begun HIV treatment programs utilizing expectedly conveyed remedies from India. These undertakings advantage more than 15 million individuals who are living with HIV/AIDS.

India prevents 'evergreening' and makes moderate generics possible

In 2005, India grasped a demanding prescription patent law that, while permitting patent security for new medication blends, makes it difficult to get a patent on new kinds of existing drugs.

The law was arranged with the goal of thwarting medication beasts from appreciating 'evergreening,' an unbelievably ordinary, and severe permitting practice in the medication business. It is featured reporting and thereafter getting segregated licenses – called 'helper licenses' – relating to various pieces of the comparable drug. Such licenses are reliably permitted in the US and various countries, in any case, India decided to compose permission to prescriptions over the business interests of the medication business.

This overall prosperity approach to manage to set demanding patent rules is according to overall trade leads and invigorates advantageous part of moderate generics into the market, driving costs down.

How the law capacities are the eventual outcome of the patent decision in 2005 which pardoned the Swiss medication association Novartis' undertaking to patent the salt/glasslike kind of 'Imatinib,' an everyday presence saving prescription for treating consistent myeloid leukemia.

Recording and getting licenses covering salt and pearl kinds of existing medication blends is a compensating game for drug affiliations and Novartis endeavored to do besides in India yet failed because of the overall prosperity shields in the patent law.

Appropriately, the prescription – imatinib mesylate – conveyed usually costs $790 per persevering each year in India stood out from $106, 322 for every patient reliably in the US.

Insignificant exertion of Indian generics Vs. unreasonable expenses of ensured drugs in the US

The costs of prescriptions in the United States are one of the most raised on earth since US laws and procedures aimlessly favor drug associations over the ordinary competition, permitting different and extended limiting frameworks on a costs of medicines, inciting extreme expenses for broad time spans. Of course, India's game plan and directors have seen ordinary competition as the most grounded and best capacity to lessen drug costs. Having fewer patients in India deduces more traditional contention, which suggests more reasonable prescriptions for people and governments in rural countries.

Rather than India's stricter patentability quantifies, the U.S. licenses the demonstration of 'evergreening' that delays customary rivalry and keeps costs high. It is an ordinary strategy by which the medication business widens its partnership on drugs past the essential patent's 20 years. The long partnership of a singular association in the US keeps costs high since regular competition is blocked.

End

No huge amazement why India is known as the "drug store to the world".

In 2015, India has exchanged medication things worth about $4 billion to Africa. This is anticipated to create more than $10 billion by 2020.

The African generics drug market is creating at 25-30% reliably and it is commonly liable to imports. It offers a basic open entryway particularly for little and moderate-sized Indian medication associations that don't satisfy the intense standards constrained by US and European masters. In Africa, Nigeria, Rwanda, South Africa, Madagascar, Zimbabwe, Tanzania, Mozambique, are the critical vendors of Indian drugs.

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emedkitmedicine · 4 years ago

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Ritonavir Tablets IP 100mg is an antiretroviral agent, prescribed for HIV (Human Immunodeficiency Virus) infectious person. Emedkit is Ritonavir Tablets IP 100mg suppliers from India that provides HIV, Cancers and other generic medicines across the world at very cost-effective prices. Emedkit is an authentic supplier and wholesaler of the generic medicines that trades across the countries as Russia, China, US, Canada, Brazil, and throughout the world.

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pharmaphorumuk · 4 years ago

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Creating sustainable access to modern medicine

It’s easy to overlook just how much the world has changed in healthcare terms over the last 40-50 years thanks to modern medicine.

From the availability of antibiotics to the transformation of HIV from a death sentence to a chronic condition, medical advances have added decades and decades to people’s lives.

But discoveries such as these are only part of the picture – we also need to get medicines into the hands of the people that need them. In HIV therapy, for example, companies like Accord, Shire, Mylan, Matrix have done a lot to aid access in that critical area.

This work has delivered a multiplicity of benefits, from slowing re-infection rates and reducing the spread of the virus to providing an affordable supply of antiretrovirals (ARVs). It is also work that could come easily undone without a sustainable medicines supply chain.

Threats to a viable supply chain

One current trend that’s making the supply base quite fragile is the commoditisation of medicines. Making price the primary driver of access is leading producers down a path of mergers and acquisitions (M&A) to become ever-bigger players in the hope it will bring them economies of scale.

The M&A trend can certainly help a company in terms of its bottom line, but it also means that everyone is resting on the same underpinning supply chain. Without plurality of supply, there’s no resilience in the system and if a major supply component goes down, it can have ripple effects throughout the supply chain, resulting in medicines shortages and ultimately depriving people of access to medicine.

“Making price the primary driver of access is leading producers down a path of M&A… Without plurality of supply, there’s no resilience in the system”

For example, at the beginning of last year, there was a surprise sequence of recalls linked to an assessment of a potential contaminant. It raised a question mark over the main active pharmaceutical ingredient supplier and that in turn impacted 70% of that product’s supply in Europe – and there was simply no way that the remaining 30% of supply could stretch to meet the demand.

That’s just one example but by no means the only instance where millions of people have been deprived of a core treatment. Such things are an often-overlooked consequence of the buy-side consolidation and a drive for medicines procurement to be carried out using a purely price-based approach.

Unfortunately, there’s no quick fix to these critical medicine issues. Pharmaceutical supply chains are not things that can be put in place rapidly, as there are long, complex arrangements for them, given the heavy regulation and oversight that is required.

Added-value versions of traditional generic medicines are one way to offer a valuable means to avoid a purely price-based approach. We are always looking for ways to go ‘beyond the tablet’ to add value and potentially secure intellectual-property protection for innovating around known molecules.

Although generics are identical to the original product, in terms of their clinical attributes, there are a number of ways in which generic products can be developed and enhanced in a non-clinical fashion.

These added-value products can add something as simple as extra pack sizes or better labelling for safety recognition, or they might offer easier ways to use that product or additional service offerings around it. All of those things can improve care, improve compliance, and improve safety.

However, they do ultimately come at a cost – if there’s no incentive for those attributes to be developed then there’s a very clear incentive to not make that effort and simply go for the lowest possible cost. Most added-value generics have the ability to improve current treatment paradigms – but only if there are economies of scale for this kind of positive innovation.

A similar sort of outlook is needed if healthcare systems are to reap the benefits of cheaper biosimilar versions of established biologic drugs for conditions like arthritis, cancer and diabetes.

Designing systems to recognise value

To improve the current market dynamic, we need to support market forces to redefine success based on value, and not price. One clear way to achieve that is to come together as a healthcare industry to lobby for the implementation of the most economically advantageous tender (MEAT) concept that looks for the ‘best value’ from medicine deals rather than simply the ‘best price’. It is only then that we can get on the right path to ensuring a sustainable generics and biosimilars business model.

Public sector organisations should be looking for products that fit the patient need and turn away from a race to the bottom. It is the only way to ensure supply chain resilience, reliability and improved products for patients.

About the author

James Burt is executive vice president EMENA, Accord Healthcare. James has over 20 years’ experience in the pharmaceutical industry, predominantly in the generics and biosimilar sector. His pharma experience includes UK, Europe, and Global management roles in commercial, business development and general management positions.

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