#stem cell therapy center of nashville

[stemcelltherapytn]

Stem Cell Therapy Center of Nashville Announces Complimentary Virtual Consultations

Stem Cell Therapy Center of Nashville located in Franklin, TN, announced today that the best in class regenerative medicine practice will be offering complimentary virtual consultations to new patients effective immediately.

[stemcelltherapycenternashville]

Stem Cell Therapy Center of Nashville - Franklin TN

At the Stem Cell Therapy Center of Nashville (Franklin, TN), we specialize in a broad range of advanced regenerative treatments designed to rejuvenate and restore your health. Our offerings include stem cell therapy, IV therapy (vitamin infusions, supplement IV infusions, as well as chelation therapy & detox therapy), bioidentical hormone replacement (BHRT), ozone therapy, PRP injections, and exosome therapy. As the premier specialists in stem cell therapy and regenerative medicine, we pride ourselves on the expertise of our board-certified doctors and specialists who are at the forefront of the regenerative medicine field. Our innovative best in class treatments are tailored and integrated to meet your unique health objectives, ensuring a personalized approach to health optimization. Our team is dedicated to delivering excellence in regenerative medicine, with a keen focus on enhancing overall well-being.

We are pleased to offer complimentary virtual and in-office consultations to begin your journey towards optimal health. #stemcelltherapy #regenerativemedicine #nashville

Stem Cell Therapy Center of Nashville 1909 Mallory Lane Suite 302D Franklin, TN 37067 (615) 709-8655 https://www.stemcelltherapycenternashville.com

[uicscience]

Top: Dr. Damiano Rondelli; above, sickle cells under a microscope.

CRISPR technology to cure sickle cell disease at UIC

University of Illinois Chicago is one of the U.S. sites participating in clinical trials to cure severe red blood congenital diseases such as sickle cell anemia or Thalassemia by safely modifying the DNA of patients’ blood cells.

The first cases treated with this approach were recently published in an article co-authored by Dr. Damiano Rondelli, the Michael Reese Professor of Hematology at the UIC College of Medicine. The article reports two patients have been cured of beta thalassemia and sickle cell disease after their own genes were edited with CRISPR-Cas9 technology. The two researchers who invented this technology received the Nobel Prize in Chemistry in 2020.  

In the paper published in the New England Journal of Medicine, CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia, researchers reported gene editing modified the DNA of stem cells by deleting the gene BCL11A, the gene responsible for suppressing fetal hemoglobin production. By doing so, stem cells start producing fetal hemoglobin so that patients with congenital hemoglobin defects (beta thalassemia or sickle cell disease) make enough fetal hemoglobin to overcome the effect of the defective hemoglobin that causes their disease.  

The advantage of this approach is that it uses the patient’s cells with no need for a donor. Also, the gene manipulation does not use a viral vector as with other gene therapy studies but is done with electroporation (quick production of pores into the cells with high voltage) which is known to have low risk of off-target gene activation, according to Rondelli.  

Sickle cell disease is an inherited defect of the hemoglobin that causes the red blood cells to become crescent-shaped. These cells can lyse and obstruct small blood vessels, depriving the body’s tissues of oxygen. The disease can cause extreme pain and damage the lungs, heart, kidneys and liver. Beta thalassemia is a blood disorder that reduces the production of hemoglobin — the iron-containing protein in red blood cells that carries oxygen to cells throughout the body. In people with beta thalassemia, low levels of hemoglobin lead to a lack of oxygen in many parts of the body.

The first two patients to receive the treatment have had successful results and continue to be monitored. Rondelli is on the steering committee for an international clinical trial, with UIC being the only site in Chicago. Although the trial is at an early stage and the first patients will be followed for some time before expanding the numbers worldwide, UIC will be among the few sites ready for this treatment.

“It is a great privilege for UIC to be part of this international study and I hope that in the future we will have our own patients undergo this procedure,” Rondelli said.

“UIC and UI Health is an ideal place for any cellular therapy in sickle cell disease because of our experience and success in stem cell transplantation in these patients. In fact, over 75% of sickle cell patients can be cured with a transplant, and we have already done over 50 cases,” he said.  

While a full-match donor is still the first line of treatment, finding a compatible stem cell donor is challenging. For this reason, many centers including UI health have developed strategies to successfully utilize donors who are only 50% compatible, called haploidentical donors. However, according to Rondelli, in about 30% to 50% of the patients, there are still multiple barriers that can limit the possibility of a donor-derived transplant, such as a family donor availability, or the presence of antibodies in the patient caused by many prior red cell transfusions, that would reject the donor stem cells.

“This gene-editing procedure has the potential to overcome all of these. Cells of the same patient can be manipulated and can be transplanted without the risk of rejection or to cause immune reactions from the donor (graft-versus-host disease),” said Rondelli. “For the almost 900 patients with SC coming to our hospital, this should be great news.”

Patients who in the future will participate in the trial will have cells sent to the CRISPR manufacturing site where the cells undergo genetic editing. Patients then receive chemotherapy prior to the edited stem cells being re-inserted into their bloodstream.  

Researchers hope this treatment can be a game-changer for world health. Sickle cell disease and beta thalassemia and other congenital blood disorders are major diseases in the world. Rondelli said 5 million people only in Nigeria suffer from sickle cell disease, and many others in Africa. Also, currently, 30% of transplants being performed in India, which has 1.3 billion people, are to treat severe beta thalassemia, he added.

“The hope is that this treatment will be accessible and affordable in many low-middle-income countries the Middle East, Africa, and India, and have an important impact in the lives of many people in these areas,” said Rondelli.

The CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia research paper was authored by Haydar Frangoul and Jennifer Domm of the Sarah Cannon Center for Blood Cancer at the Children’s Hospital at TriStar Centennial, Nashville; Akshay Sharma of St. Jude Children’s Research Hospital, Memphis; David Altshuler, Brenda K Eustace, Julie Lekstrom-Himes and Angela Yen of Vertex Pharmaceuticals; Martin Steinberg of Boston University School of Medicine; Yi-Shan Chen, Tony Ho, Andrew Kernytsky and Sandeep Soni of CRISPR Therapeutics, Cambridge, Massachusetts; M. Domenica Cappellini of University of Milan; Franco Locatelli of Ospedale Pediatrico Bambino Gesù Rome, Sapienza, University of Rome; Juergen Foell and Selim Corbacioglu of University of Regensburg, Regensburg, Germany; Rupert Handgretinge of Children’s University Hospital, University of Tübingen, Tübingen, Germany; Josu de la Fuente of Imperial College Healthcare NHS Trust, St. Mary’s Hospital, London; Stephan Grup of Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia; Antonis Kattamis of University of Athens, Athens; Amanda Li of BC Children’s Hospital, University of British Columbia, Vancouver; Donna Wall of Hospital for Sick Children-University of Toronto; Markus Mapara of Columbia University, New York; Sujit Sheth of Joan and Sanford I. Weill Medical College of Cornell University, New York; Mariane de Montalembert of Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris; and Damiano Rondelli, University of Illinois Chicago.

Funded by CRISPR Therapeutics and Vertex Pharmaceuticals; ClinicalTrials.gov numbers, NCT03655678 for CLIMB THAL-111 and NCT03745287 for CLIMB SCD-121.

[jamesgeiiger]

GE Healthcare, Vanderbilt University Medical Center Partner for Safer, More Precise Immunotherapy Cancer Treatment

CHICAGO & NASHVILLE, Tenn. — GE Healthcare and Vanderbilt University Medical Center (VUMC) today announced a five-year partnership to enable safer and more precise cancer immunotherapies. Multiple diagnostic tools will be developed to help predict both the efficacy of an immunotherapy treatment and its adverse effects for a specific patient before the therapy is administered. This would allow physicians to better target immunotherapies to the right patients and avoid potentially damaging, ineffective and costly courses of treatments.

Immunotherapies use the immune system to recognize and attack cancer cells and can be more effective than traditional treatments, but response rates are often low and side effects can be severe1. GE Healthcare and VUMC will retrospectively analyze and correlate the immunotherapy treatment response of thousands of VUMC cancer patients, with their anonymized demographic, genomic, tumor, cellular, proteomic and imaging data. They will then develop AI-powered apps that draw on this data to help physicians identify the most suitable treatment for each individual patient.

Simultaneously, GE Healthcare and VUMC will develop new positron-emission tomography (PET) imaging tracers, which together with the apps, will help physicians to stratify cancer patients for clinical trials. It currently takes an average of 12 years2 and costs almost $2bn3 to bring a drug to market. In many cases, inappropriate patients are recruited to participate in immunotherapy trials, incurring unnecessary expense and slowing down approvals of new therapies. It is hoped that the PET tracers will ultimately also be used to monitor the efficacy of immunotherapies in everyday practice.

“Immunotherapy offers tremendous promise but given the current unpredictability of some patients’ reactions to treatments, it is also associated with increased morbidity and cost. This partnership provides the opportunity to leverage strengths of both of our organizations to further personalize cancer care by creating new tools that allow clinicians to more accurately predict how patients will respond to a specific therapy,” said Jeff Balser, MD, PhD, President and Chief Executive Officer, Vanderbilt University Medical Center and Dean of the Vanderbilt University School of Medicine.

“GE Healthcare and Vanderbilt will combine their data science, genomic, imaging and cellular analysis capabilities to help improve clinical decision making. This partnership is a great example of the increasing convergence of the tools, technologies and data used by therapy innovators and healthcare providers,” said Kieran Murphy, President and Chief Executive Officer, GE Healthcare.

GE Healthcare and the Vanderbilt-Ingram Cancer Center, a world-renowned stem cell transplant facility, will also collaborate on methods to improve productivity, efficiency and cost of stem cell transplant processing operations by automating processes, digitizing workflows, improving throughput and industrializing operations.

The first analytics application prototype will be available by the end of 2019 and the PET tracer proof-of-concept by the end of 2020.

### END ###

About Vanderbilt University Medical Center Vanderbilt University Medical Center (VUMC) is one of the nation’s leading academic medical centers and is the largest comprehensive health system in Tennessee. Its core missions are the delivery of patient care, performing biomedical research and training future leaders in health care. VUMC is the recipient of top accolades by the National Academies, the Magnet Recognition Program, the Leapfrog Group, and has been named a Top Hospital by Truven Health Analytics 14 times. In 2018, U.S. News & World Report named VUMC to the ‘Honor Roll’ of the nation’s top 20 hospitals with 10 nationally-ranked adult specialty programs. In 2018, U.S. News also named the Monroe Carell Jr. Children’s Hospital at Vanderbilt among the nation’s ‘Best Children’s Hospitals’ with 10 out of 10 pediatric specialty programs nationally ranked. For more information and the latest news follow Vanderbilt Health on Facebook, LinkedIn, Twitter, and in the VUMC Reporter.

About GE Healthcare GE Healthcare is the $19 billion healthcare business of GE (NYSE: GE). As a leading provider of medical imaging, monitoring, biomanufacturing, and cell and gene therapy technologies, GE Healthcare enables precision health in diagnostics, therapeutics and monitoring through intelligent devices, data analytics, applications and services. With over 100 years of experience in the healthcare industry and more than 50,000 employees globally, the company helps improve outcomes more efficiently for patients, healthcare providers, researchers and life sciences companies around the world. Follow us on Facebook, LinkedIn, Twitter and The Pulse for latest news, or visit our website www.gehealthcare.com for more information.

These statements are not guarantees of future performance and undue reliance should not be placed on them.

__________________________ 1https://www.cancer.net/blog/2018-02/what-you-need-know-about-immunotherapy-side-effects 2https://www.sciencedirect.com/science/article/pii/S2452302X1600036X 3https://www2.deloitte.com/us/en/pages/life-sciences-and-health-care/articles/measuring-return-from-pharmaceutical-innovation.html

Contacts

GE Healthcare David Morris David.j.morris@ge.com 0044 7920 591370

Vanderbilt University Medical Center John Howser John.Howser@vumc.org 001 615-322-4747

GE Healthcare, Vanderbilt University Medical Center Partner for Safer, More Precise Immunotherapy Cancer Treatment published first on https://worldwideinvestforum.tumblr.com/

[mikemortgage]

GE Healthcare, Vanderbilt University Medical Center Partner for Safer, More Precise Immunotherapy Cancer Treatment

CHICAGO & NASHVILLE, Tenn. — GE Healthcare and Vanderbilt University Medical Center (VUMC) today announced a five-year partnership to enable safer and more precise cancer immunotherapies. Multiple diagnostic tools will be developed to help predict both the efficacy of an immunotherapy treatment and its adverse effects for a specific patient before the therapy is administered. This would allow physicians to better target immunotherapies to the right patients and avoid potentially damaging, ineffective and costly courses of treatments.

Immunotherapies use the immune system to recognize and attack cancer cells and can be more effective than traditional treatments, but response rates are often low and side effects can be severe1. GE Healthcare and VUMC will retrospectively analyze and correlate the immunotherapy treatment response of thousands of VUMC cancer patients, with their anonymized demographic, genomic, tumor, cellular, proteomic and imaging data. They will then develop AI-powered apps that draw on this data to help physicians identify the most suitable treatment for each individual patient.

Simultaneously, GE Healthcare and VUMC will develop new positron-emission tomography (PET) imaging tracers, which together with the apps, will help physicians to stratify cancer patients for clinical trials. It currently takes an average of 12 years2 and costs almost $2bn3 to bring a drug to market. In many cases, inappropriate patients are recruited to participate in immunotherapy trials, incurring unnecessary expense and slowing down approvals of new therapies. It is hoped that the PET tracers will ultimately also be used to monitor the efficacy of immunotherapies in everyday practice.

“Immunotherapy offers tremendous promise but given the current unpredictability of some patients’ reactions to treatments, it is also associated with increased morbidity and cost. This partnership provides the opportunity to leverage strengths of both of our organizations to further personalize cancer care by creating new tools that allow clinicians to more accurately predict how patients will respond to a specific therapy,” said Jeff Balser, MD, PhD, President and Chief Executive Officer, Vanderbilt University Medical Center and Dean of the Vanderbilt University School of Medicine.

“GE Healthcare and Vanderbilt will combine their data science, genomic, imaging and cellular analysis capabilities to help improve clinical decision making. This partnership is a great example of the increasing convergence of the tools, technologies and data used by therapy innovators and healthcare providers,” said Kieran Murphy, President and Chief Executive Officer, GE Healthcare.

GE Healthcare and the Vanderbilt-Ingram Cancer Center, a world-renowned stem cell transplant facility, will also collaborate on methods to improve productivity, efficiency and cost of stem cell transplant processing operations by automating processes, digitizing workflows, improving throughput and industrializing operations.

The first analytics application prototype will be available by the end of 2019 and the PET tracer proof-of-concept by the end of 2020.

### END ###

About Vanderbilt University Medical Center Vanderbilt University Medical Center (VUMC) is one of the nation’s leading academic medical centers and is the largest comprehensive health system in Tennessee. Its core missions are the delivery of patient care, performing biomedical research and training future leaders in health care. VUMC is the recipient of top accolades by the National Academies, the Magnet Recognition Program, the Leapfrog Group, and has been named a Top Hospital by Truven Health Analytics 14 times. In 2018, U.S. News & World Report named VUMC to the ‘Honor Roll’ of the nation’s top 20 hospitals with 10 nationally-ranked adult specialty programs. In 2018, U.S. News also named the Monroe Carell Jr. Children’s Hospital at Vanderbilt among the nation’s ‘Best Children’s Hospitals’ with 10 out of 10 pediatric specialty programs nationally ranked. For more information and the latest news follow Vanderbilt Health on Facebook, LinkedIn, Twitter, and in the VUMC Reporter.

About GE Healthcare GE Healthcare is the $19 billion healthcare business of GE (NYSE: GE). As a leading provider of medical imaging, monitoring, biomanufacturing, and cell and gene therapy technologies, GE Healthcare enables precision health in diagnostics, therapeutics and monitoring through intelligent devices, data analytics, applications and services. With over 100 years of experience in the healthcare industry and more than 50,000 employees globally, the company helps improve outcomes more efficiently for patients, healthcare providers, researchers and life sciences companies around the world. Follow us on Facebook, LinkedIn, Twitter and The Pulse for latest news, or visit our website www.gehealthcare.com for more information.

These statements are not guarantees of future performance and undue reliance should not be placed on them.

__________________________ 1https://www.cancer.net/blog/2018-02/what-you-need-know-about-immunotherapy-side-effects 2https://www.sciencedirect.com/science/article/pii/S2452302X1600036X 3https://www2.deloitte.com/us/en/pages/life-sciences-and-health-care/articles/measuring-return-from-pharmaceutical-innovation.html

Contacts

GE Healthcare David Morris David.j.morris@ge.com 0044 7920 591370

Vanderbilt University Medical Center John Howser John.Howser@vumc.org 001 615-322-4747

from Financial Post http://bit.ly/2TuoP7q via IFTTT Blogger Mortgage Tumblr Mortgage Evernote Mortgage Wordpress Mortgage href="https://www.diigo.com/user/gelsi11">Diigo Mortgage

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[chicagostemcell]

Regenerative Medicine, Stem Cell therapy, A swift unfolding discipline

Overview

The ability of the human body to heal itself is remarkably apparent in a cutting edge new treatment known as regenerative stem cell therapy, which Pain Management Specialist and Anesthesiologist Zaki Anwar MD, founder of the Chicago Stem Cell Therapy Center and Sports Medicine has practiced more often to aid and attain pain free life in patients with chronic knee pain and shoulder ailments

Regenerative therapy a part of medicine

A significant study of the branch of medicine known as the Regenerative Medicine, Stem Cell therapy that takes advantage of mature as well as immature, self stimulating cells raised in the bone marrow to renew and regrow a wide range of cells and tissues. “This swiftly unfolding discipline, the direction of in depth research is serving people recover rapidly and more naturally as well they can avoid surgical treatments and other painful methods” says Dr. Zaki Anwar. MD who established the Chicago Stem Cell Therapy Center who completed his Fellowship in Pain Management and Sports Medicine from the University of Vanderbilt, Nashville, Tennessee

Stem cells proven the recovery

“Stem cells have proven the regeneration and recovery of bodily tissues damaged over time with the wear and tear or any severe injury.” he explains. “Professional players and athletes have been taking the stem cell therapy for decades and credit regenerative medicine for their successful return to competition or otherwise they had to endure adverse sports injuries. However, not only athletes, now even a common individual among us can reap the rewards too. Stem cell therapy is not new- but the onset of advanced technology and techniques means stem cell can now be taken advantage to help even more patients with problem of muscles, tendons, ligaments organs or even bones, including injury wear and tear and degeneration to recover and administered by just an injection on an outpatient basis”

Understanding how stem cells work

The question that is right now arises in your mind is how does the regenerative therapy work? For bone injuries and other degenerated tissues, a kind of stem cell is raised in the adult bone marrow called mesenchymal stem cells, or MSCs is required. These stem cells swiftly multiply and bring about a number of so called constitutional cells in the body, such as muscles, bone, fat, tendons, ligaments or cartilage

The procedure is extraordinarily simple and rapid. In a physician’s office, a small vial of cells is removed and injected back into the targeted area, such as knee, shoulder, wrist, or elbow

Regenerative Stem Cell for Knee

The Regenerative stem cell treatment is now being used to treat knee pain due to conditions such as arthritis, meniscus tears, ACL ligament injuries, wear and tear injury and degenerative condition

Regenerative Stem cell for shoulder

“In the shoulder stem cells are being used to heal arthritis, rotator cuff  tears, labral tears and other injuries” says Dr. Zaki Anwar, MD 

[stemcelltherapycenternashville]

Stem Cell Therapy Center of Nashville 1909 Mallory Lane Suite 302D Franklin, TN 37067 (615) 709-8655 https://www.stemcelltherapycenternashville.com

At the Stem Cell Therapy Center of Nashville (Franklin, TN), we specialize in a broad range of advanced regenerative treatments designed to rejuvenate and restore your health. Our offerings include stem cell therapy, IV therapy (vitamin infusions, supplement IV infusions, as well as chelation therapy & detox therapy), bioidentical hormone replacement (BHRT), ozone therapy, PRP injections, and exosome therapy. As the premier specialists in stem cell therapy and regenerative medicine, we pride ourselves on the expertise of our board-certified doctors and specialists who are at the forefront of the regenerative medicine field. Our innovative best in class treatments are tailored and integrated to meet your unique health objectives, ensuring a personalized approach to health optimization. Our team is dedicated to delivering excellence in regenerative medicine, with a keen focus on enhancing overall well-being.

We are pleased to offer complimentary virtual and in-office consultations to begin your journey towards optimal health.

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