#reverse aging telomeres

[shiut]

Homunculus Research (the kinda scientific edition)

Time for me to do the thing that I do where I think way too much about barely explained fictional science and try my best to apply actual science to it. For fun.

So, here is my biological summary for the homunculi of Rain Code, which will be mostly non-canon speculation.

What is a homunculus? A homunculus is an artificially created, cloned individual using the genetic information of a human for the purpose of developing immortality and regeneration applicable to military use.

What is a homunculus made of and how? A homunculus is created from gram-negative bacteria and human cells through complete recombinant DNA cloning. This technique is achieved through taking the genes of the human donor and incorporating the information into a bacterial chromosomal DNA and plasmid(the secondary circular DNA molecule of bacteria used for gene replication and transfer). Additionally, the incorporation of the enzyme telomerase and protein p53 is applied.

What contributes to a homunculus's regenerative properties and immortality? Homunculi exhibit accelerated initial growth and healing thanks to the bacterial hybridization of their cells. Bacteria have one of the fastest replication rates, and can replicate at a rate of about every 10 minutes compared to the average human cell's replication rate of every 24 hours. Gram-negative bacteria also have a complex layering of membrane that allow them to be more resistant to antibiotics and a more sturdy structure. Bacteria have the ability to go through inactivation, where they go into a state of metabolic dormancy that protect them and allow them to be able to wait out periods of extreme conditions and nutrient scarcity. Telomerase, the 'immortality enzyme', is utilized for its function in restoring the length of telomeres. Telomeres are a protective chromosomal cap that normally erode with each cell division, and it's this shortening that causes DNA damage and aging in humans. Telomerase repairs this erosion and allows cells to divide indefinitely. However, because of telomerase's link to increased rates of cancer, additional copies of the gene responsible for the production of p53 protein is also incorporated. P53 is a tumor suppressor that allows damaged cells to repair themselves before dividing, which prevents the spread of cancerous cells.

Why is homunculus blood pink? Gram-negative bacteria is identifiable for its bright pink color by using the gram staining method. This is because the characteristic cell wall structure of gram-negative bacteria which makes them so resilient also causes the bacteria to display the color of the safranin. Homunculus researchers may apply a gram staining process to the circulatory system of homunculi for the purpose of identification and observation.

Relevance of gram-negative bacteria in gene cloning and military research. The most commonly used strain of bacteria used in gene cloning research is the gram-negative bacteria such as e. coli for its ready availability, ease of growth and manipulation, and simplicity. Gram-negative bacteria such as e. coli has a history in military research, in cases such as a probiotic when an army surgeon isolated a strain found in a soldier who, unlike his comrades, did not develop an illness from an infectious outbreak.

What is the zombified state of imperfect homunculi? It is the result of cell inactivation that, while it is a protective measure for the cells, the slowed or halted metabolic state causes the low-functioning mental and physical faculties that present zombie-like symptoms, and is currently difficult to impossible to reverse in imperfect homunculi due to their varying degrees of cellular instability.

Why do imperfect homunculi require compounds found in human flesh for nutrients? Plasmid stability in DNA cloned cells is often influenced by the original donor's genotype. Imperfect homunculi cells may include defects in the cell division process where the stability of the human DNA contained in the cell plasmid results in incomplete DNA replication, whereas each division causes informational gaps in the gene and interrupt protein synthesis. These gaps can be filled and repaired by taking and incorporating the required information from a healthy human cell through the process of horizontal gene transfer. Human matter must be consumed and broken down in order for the homunculus cells to initiate this process. The lack of these nutrients can cause the homunculus cells to go into a state of inactivation.

Why are imperfect homunculi vulnerable to sunlight? UV has been known to exhibit antimicrobial effects. Many bacteria, especially gram-negative bacteria, are averse to sunlight. Exposure to the UV radiation in sunlight results in the damage or solar induced inactivation of unstable homunculus cells.

Written, hopefully, as simplified and concise as possible for readability. I feel like I'm forgetting more things I wanted to address, but maybe I'll just leave it here and just make more parts if I think of it :P

[metamatar]

This project is not something a researcher would ever write a grant proposal for. It’s an exploration that threatens to reverse an entrenched idea—that T cells have an intrinsically limited capacity to fight—with no guarantee of success. “It’s almost a historically monumental experiment to do. No one does an experiment that lasts 10 years,” says Wherry. “It’s antithetical to funding mechanisms, and a five-year funding cycle—which really means every three years you have to be doing something new. It’s antithetical to the way we train our students and postdocs who typically are in a lab for four or five years. It’s antithetical to the short attention span of scientists and the scientific environment we live in. So it really says something fundamental about really, really wanting to address a critically important question.”

Indeed, the project remained unfunded for the first eight years, surviving just on lab members’ spare time. But its central question was ambitious: Must immune cells age? In 1961, microbiologist Leonard Hayflick argued that all of our cells (except eggs, sperm, and cancer) could only divide a finite number of times. In the 1980s, researchers advanced the idea that this might play out through the erosion of protective telomeres—a sort of aglet at the end of chromosomes—which shorten when cells divide. After enough divisions, there’s no more telomere left to protect the genes.

This project challenged the Hayflick limit.

[cashewcashew]

i was obsessed with the molecular bio / epigenetics approach to stopping/reversing aging for a bit and unfortunately it likely will not be a thing in any of our lifetimes due to just how much goes into it.

between telomeres and removing stress induced epigenetic stuff and a whole host of other factors, science just doesn’t move THAT quick to make reversing aging a possibility in the next 7-10 decades.

that dental regeneration stuff looks hype though i’m very excited to see that come to fruition since it’s far more feasible with current stem cell tech (assuming legal/ethical barriers don’t hold it back)

[adrielcloud]

Rethinking Death Through Regeneration and Resurrection Ecology

The history of the world, as natural history, is nothing more than a stratification of events and processes that are never definitively ‘dead and buried’, but which continue to flow and exert an active force from a lower, or even subterranean, dimension than the present—events and processes that can also reappear in an altered form, upsetting our temporal perception. This characteristic pluriversality amounts to the preeminence of reality over imagination, i.e. the hierarchical superiority of natural processes over thought. 

- Chapter ‘For a chaotic vision of time’, Gruppo di Nun, Revolutionary Demonology

Death in secular societies is often viewed as the ultimate, irreversible conclusion to life. This perception is deeply rooted in our understanding of human biological mortality, where once the brain stops functioning and the heart ceases to beat, life is considered to be over, with no continuation beyond the bodily processes. This perspective is not universal, it's profoundly influenced by cultural, religious, and philosophical belief systems that offer different interpretations of what happens after the physical body ceases to function. In many spiritual and religious traditions death is not seen as the end of life but rather a transition to a different form of existence. For those who believe in reincarnation the end of the physical body does not signify the end, instead it is believed that the soul after leaving the body is reborn into a new one, continuing its journey through successive lives. This cyclical view of life and death suggests that death is merely a passage from one form of life to another, rather than an absolute conclusion.

The idea that human life can be prolonged, renewed, or even reanimated has been portrayed in diverse and evolving ways, from the pages of early science fiction to the screens of modern cinema, and increasingly within scientific laboratories. These portrayals reflect humanity’s enduring fascination with mortality and the relentless pursuit of ways to transcend it.  

Real-world efforts by the biotech industry pursue the reversal of ageing and, by extension, death itself. Peter Thiel, the tech billionaire known for his ventures into disruptive technologies, is one of the prominent figures leading the charge against growing old. His investments in biotech firms that focus on anti-aging research aim to challenge the inevitability of death by targeting the biological processes that cause ageing. Thiel and other tech entrepreneurs are exploring various avenues, from cellular reprogramming to extending telomeres—the protective caps on chromosomes that shorten with age. These efforts are rooted in the belief that ageing is a disease that can be cured and that, by doing so, the human lifespan can be dramatically extended, potentially leading to a future where death is no longer an unavoidable fate.

Immortality finds parallels in nature, where certain organisms possess regenerative abilities that defy the typical constraints of life and death. The immortal jellyfish (Turritopsis dohrnii), for instance, can revert to its immature polyp stage after reaching adulthood, effectively resetting its biological clock. This form of biological immortality allows the jellyfish to escape death, at least theoretically, by continuously cycling between life stages. Such natural examples of regeneration challenge our human-centric understanding of mortality, suggesting that life can persist in forms we barely understand.

Resurrection Ecology, which studies species that can revive after long periods of dormancy is an example of how life adapts and persists through extreme environmental conditions. This fascinating field studies the potential for ecosystems to recover or "resurrect" from extreme disturbances by analysing ancient organisms and their genetic material. A notable example involves the freshwater crustacean Daphnia, which can produce eggs that remain dormant in sediments for decades or even centuries. When environmental conditions become favourable again, these eggs can hatch, effectively resurrecting a population that had seemingly vanished. This process not only illustrates the resilience of certain species but also provides valuable insights into how ecosystems might regenerate after severe disruptions, such as climate change or human-induced environmental damage. As Gruppo di Nun notes in Revolutionary Demonology, the history of the natural world is one of "pluriversality," where even buried processes exert their influence across time. This suggests that nature operates with a chaotic, layered temporality, where the past re-emerges in altered forms, reshaping the present.

Cryptobiosis (literally meaning hidden life), is where the metabolic rate of an organism is reduced to an imperceptible level, showing no visible signs of life.' Cryptobiosis includes anhydrobiosis (life without water), cryobiosis (life at low temperatures), and anoxybiosis (life without oxygen). In the cryptobiotic state, all metabolic procedures stop, preventing reproduction, development, and repair where an organism can live almost indefinitely while it waits for environmental conditions to become better.

Within the human body, certain tissues and organs possess a remarkable ability to regenerate. The liver, for example, can recover from substantial damage by regenerating its lost tissue, a phenomenon that was mythologized in the story of Prometheus. Chained to a rock, Prometheus’s liver was eaten by an eagle each day, only to regenerate by night—a tale that ancient Greeks may have used to symbolise the resilience of this vital organ. Modern science confirms that the liver’s regenerative capacity is indeed exceptional, but it also highlights the limits of human regeneration. While some tissues like the endometrium and fingertips can regenerate to some extent, the loss of limbs or severe damage to the brain remains beyond our bodily capacity to repair.

Scientists are exploring ways to harness the body’s own regenerative mechanisms or induce regeneration in tissues that typically do not regenerate. The goal is to develop therapies that can restore lost or damaged tissues, effectively turning back the biological clock on a cellular level. 

Axolotls are remarkable for their ability to regenerate lost or damaged body parts, which has long fascinated scientists, particular for stem cell research. Beyond limbs, axolotls can regenerate vital organs like the heart, lungs, and even segments of their spinal cord, restoring function. They can also regenerate parts of their brain and eyes, something highly unusual in vertebrates. Unlike most animals, they heal without scarring, maintaining the full functionality of the regenerated tissue. This regenerative ability holds potential for human medicine, if researchers can unlock the genetic and cellular processes enabling axolotl regeneration, it might one day be possible to apply these insights to humans. This could revolutionise treatments for injuries like spinal cord damage, heart disease, or limb loss.

The implications of these developments reach far beyond individual organisms, extending into the broader ecological context. Just as a liver or jellyfish can regenerate, so too can ecosystems—though with varying degrees of success. For example, forests can regrow after fires, but this regeneration is influenced by a multitude of environmental factors, leading to variable processes and outcomes. Similarly, the global ecosystem, under increasing threat from climate change, will inevitably undergo its own form of regeneration. Some life will persist, some species will go extinct, and others may enter strange states of dormancy.

These ideas challenge our Western notions of life and death. Traditionally viewed as a final, irreversible state, death can instead be reimagined as a transitional phase—one that contains the potential for the (re)emergence of life.

[allthenewzworld]

A Florida scientist who spent 100 days underwater claims to still experience some health benefits nine months after returning to land.

Retired Navy diver Joseph Dituri spent this record-breaking time in a bunker 30 feet below the Atlantic Ocean's surface, in a high-pressure environment he credits with reversing his body's age on a cellular level.

Upon emerging in June of last year, Dituri reported blood tests showing a 50% reduction in all inflammatory markers, a 17-fold increase in stem cells, and longer telomeres-structures on chromosomes believed to be linked to life extension.

Read more at link in our bio.

#news #scientist #underwater #record #newrecord #allthenewz

[openintegrative]

DNA & Longevity: Can You Live to 200?

Longevity is shaped by a mix of genetics and lifestyle.

Certain genes are linked to longer lifespans.

Lifestyle choices can influence how long you live.

Science suggests living to 200 may be possible, but there are challenges.

Understanding your DNA can help you make choices for a longer life.

Introduction

The idea of living to 200 years old sparks curiosity and ambition. While many factors contribute to how long we live, genetics plays a significant part.

We can explore what might be possible in extending human life by understanding the role of DNA in longevity.

The Science of Longevity

Genetics strongly impacts how long we live. Certain genes, like SIRT1, FOXO3, and IGF-1, are linked to longer lifespans.

Telomeres, which protect our chromosomes, also play a key part in determining lifespan. As they shorten, cells age, leading to aging in the body.

Potential for Living to 200

Current science explores the limits of human lifespan. Research on people who live past 100, known as centenarians, and those who live past 110, known as supercentenarians, provides insights into how long humans might live.

With advancements in technology and understanding, living to 200 could become a reality, though it remains a significant challenge.

Genetic Factors Affecting Longevity

Genetic variations can slow down aging processes. Some people naturally have mutations that help their bodies repair DNA more effectively, which could contribute to a longer life.

Understanding these genetic factors gives us a better picture of what might be possible in extending lifespan.

Lifestyle and Environmental Influences

Your environment and lifestyle heavily influence your longevity. Diet, exercise, and other habits can either support or hinder your genetic potential for a long life.

Make metabolic health a top priority by balancing key minerals, especially copper and magnesium, and optimizing important enzymes like ceruloplasmin and superoxide dismutase.

Efforts should be made to prevent iron dysregulation. When iron accumulates in cells, it can catalyze the formation of free radicals, leading to damage of proteins, fats, and DNA.

You can maximize your chances of living longer by making healthy choices even if your genes aren’t perfect.

Future of Longevity Research

The future of longevity lies in advancements like gene therapy and CRISPR technology. Scientists are also exploring anti-aging drugs and other treatments that could slow or reverse aging.

As this research progresses, we might get closer to the possibility of living much longer lives. However, ethical questions arise as we consider the implications of such advances.

Challenges and Limitations

While the idea of living to 200 is intriguing, there are many challenges. Biological limits, societal impacts, and the potential downsides of extreme longevity all come into play.

It’s important to balance the desire for a longer life with the need for a high quality of life.

Conclusion

Living to 200 years old might be within reach, but it requires a deep understanding of genetics, lifestyle, and emerging technologies. While the future holds promise, focusing on healthy living now remains the best approach to a longer, healthier life.

FAQ

What genes are most associated with long life? Genes like SIRT1, FOXO3, and IGF-1 are closely linked to longevity.

How does lifestyle interact with genetics to affect lifespan? Lifestyle choices like diet and exercise can enhance or limit your genetic potential for a long life.

Is it realistic to expect humans to live to 200 years? While theoretically possible, significant scientific and ethical challenges must be addressed.

What are the ethical implications of significantly extending human life? Extending life raises questions about resource use, societal impacts, and quality of life.

How can current genetic technology help in achieving longer lifespans? Advances in gene therapy and CRISPR may offer ways to slow aging and extend life.

Research

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Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993). Oxidants, antioxidants, and the degenerative diseases of aging. Proceedings of the National Academy of Sciences of the United States of America, 90(17), 7915-7922. https://doi.org/10.1073/pnas.90.17.7915

Ashraf, A., Clark, M., & So, P. (2018). The Aging of Iron Man. Frontiers in Aging Neuroscience, 10, 344384. https://doi.org/10.3389/fnagi.2018.00065

Azzi, A., Davies, K.J.A. and Kelly, F., 2004. Free radical biology – terminology and critical thinking. FEBS Letters, [online] 558(1–3), pp.3–6. https://doi.org/10.1016/s0014-5793(03)01526-6.

Beckman, K.B. and Ames, B.N., 1997. Oxidative Decay of DNA. Journal of Biological Chemistry, [online] 272(32), pp.19633–19636. https://doi.org/10.1074/jbc.272.32.19633.

BECKMAN, K.B. and AMES, B.N., 1998. The Free Radical Theory of Aging Matures. Physiological Reviews, [online] 78(2), pp.547–581. https://doi.org/10.1152/physrev.1998.78.2.547.

Chen, W.J., Kung, G.P. and Gnana-Prakasam, J.P., 2022. Role of Iron in Aging Related Diseases. Antioxidants, [online] 11(5), p.865. https://doi.org/10.3390/antiox11050865.

Darnell, J.E., Lodish, H.F. and Baltimore, D., 1986. Molecular cell biology. Springer.

Frei, B., Forte, T.M., Ames, B.N. and Cross, C.E., 1991. Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid. Biochemical Journal, [online] 277(1), pp.133–138. https://doi.org/10.1042/bj2770133.

Galaris, D., Mantzaris, M. and Amorgianiotis, C., 2008. Oxidative stress and aging: the potential role of iron. Hormones, [online] 7(2), pp.114–122. https://doi.org/10.1007/bf03401502.

Harman D. The aging process. Proc Natl Acad Sci U S A. 1981 Nov;78(11):7124-8. doi: 10.1073/pnas.78.11.7124. PMID: 6947277; PMCID: PMC349208.

Harman, D., 1969. PROLONGATION OF LIFE: ROLE OF FREE RADICAL REACTIONS IN AGING. Journal of the American Geriatrics Society, [online] 17(8), pp.721–735. https://doi.org/10.1111/j.1532-5415.1969.tb02286.x.

Meneghini, R. (1997). Iron Homeostasis, Oxidative Stress, and DNA Damage. Free Radical Biology and Medicine, 23(5), 783-792. https://doi.org/10.1016/S0891-5849(97)00016-6

Pellowski, D., Heinze, T., Tuchtenhagen, M., Müller, S.M., Meyer, S., Maares, M., Gerbracht, C., Wernicke, C., Haase, H., Kipp, A.P., Grune, T., Pfeiffer, A.F.H., Mai, K. and Schwerdtle, T., 2024. Fostering healthy aging through selective nutrition: A long-term comparison of two dietary patterns and their holistic impact on mineral status in middle-aged individuals—A randomized controlled intervention trial in Germany. Journal of Trace Elements in Medicine and Biology, [online] 84, p.127462. https://doi.org/10.1016/j.jtemb.2024.127462.

Pouillot A, Polla A, Polla BS. Iron and iron chelators: a review on potential effects on skin aging. Curr Aging Sci. 2013 Dec;6(3):225-31. doi: 10.2174/18746098112059990037. PMID: 23866012.

Rattan, S.I.S., 2006. Theories of biological aging: Genes, proteins, and free radicals. Free Radical Research, [online] 40(12), pp.1230–1238. https://doi.org/10.1080/10715760600911303.

Richter, C., Park, J.W. and Ames, B.N., 1988. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proceedings of the National Academy of Sciences, [online] 85(17), pp.6465–6467. https://doi.org/10.1073/pnas.85.17.6465.

Sohal, R.S. and Weindruch, R., 1996. Oxidative Stress, Caloric Restriction, and Aging. Science, [online] 273(5271), pp.59–63. https://doi.org/10.1126/science.273.5271.59.

Tian, Y., Tian, Y., Yuan, Z., Zeng, Y., Wang, S., Fan, X., Yang, D. and Yang, M., 2022. Iron Metabolism in Aging and Age-Related Diseases. International Journal of Molecular Sciences, [online] 23(7), p.3612. https://doi.org/10.3390/ijms23073612.

Waiter, P.B., Beckman, K.B. and Ames, B.N., 1999. The role of iron and mitochondria in aging. OXIDATIVE STRESS AND DISEASE, 2, pp.203-228.

Xu, J., Marzetti, E., Seo, A.Y., Kim, J.-S., Prolla, T.A. and Leeuwenburgh, C., 2010. The emerging role of iron dyshomeostasis in the mitochondrial decay of aging. Mechanisms of Ageing and Development, [online] 131(7–8), pp.487–493. https://doi.org/10.1016/j.mad.2010.04.007.

Zeidan, R.S., Han, S.M., Leeuwenburgh, C. and Xiao, R., 2021. Iron homeostasis and organismal aging. Ageing Research Reviews, [online] 72, p.101510. https://doi.org/10.1016/j.arr.2021.101510

[lexical-lushes]

[Emily] one aspect is healthspan.

aging /is/, in fact, a process of degradation, at least in a biological sense - most of the detrimental effects we associate with old age are a result of the biological processes that keep our bodies repaired slowly breaking down due to things like telomere shortening (the process in which your genes replicating very gradually wears down their genetic code and can eventually cause replication errors and cell death).

so past a certain point, your body starts to wear out from under you - your motor function degrades, your body gets stiffer, maybe your mind starts to go... and then if you fall and break a hip that's potentially lethal, or your heart gives out because its physical structure has grown too weak, or you have a fatal stroke, or whatever.

so anti-aging treatments are about reversing or stalling this degradation so that your body remains healthy and functional longer.

potentially living to 100 doesn't do much good if the last 25-50 years are miserable because your body is falling apart.

"aging is fascism" is an undeniably dumb take, but like... the underlying point of "we can or soon will be able to prevent the detrimental effects of aging and this is a good thing" isn't actually wrong.

this isn't about "trying to stop linear time", it's about healthcare. we have biological clocks in all our cells that are counting down until the days that sickness and ill-health become increasingly inevitable - shouldn't we try to stop or at least slow them?

scrunching my face real hard rn

[discoverybody]

Does Hyperbaric Oxygen Therapy (HBOT) Reverse Aging

Hyperbaric Oxygen Therapy (HBOT) is a medical treatment that involves patients breathing pure oxygen in a pressurized chamber. It is widely used to treat decompression sickness, carbon monoxide poisoning, and wounds that do not heal properly. Recently, there has been a growing interest in HBOT's ability to reverse the aging process.

HBOT enhances oxygen flow to the body's tissues, which promotes healing and reduces inflammation. It also increases the creation of new blood vessels, which can aid with circulation. While HBOT is already utilized to treat a variety of medical conditions, its potential anti-aging effects are still being investigated.

According to some research, HBOT may have anti-aging effects by lengthening telomeres and slowing cellular senescence. Telomeres are protective caps on chromosomes that shorten with age, and cellular senescence is linked to aging. HBOT may also increase mitochondrial activity, which decreases with aging and contributes to age-related diseases.

Furthermore, HBOT may reduce oxidative stress and inflammation, improving cellular health and possibly reducing the aging process. However, further research is required to properly understand HBOT's processes and potential anti-aging applications.

It is crucial to highlight that HBOT is not a cure-all for aging and should not be used as a substitute for a healthy lifestyle. While there is some scientific evidence that HBOT has potential anti-aging advantages, additional research is needed to establish its effectiveness.

[perfecthealthsciences]

Exploring Lifespan.io and the Exciting World of Anti-Aging

In the quest for eternal youth, humanity has long been captivated by the idea of extending lifespan and delaying the aging process. From ancient myths of magical fountains to modern scientific breakthroughs, the pursuit of longevity has been a timeless endeavor. In recent years, platforms like Lifespan.io have emerged as beacons of hope, uniting researchers, enthusiasts, and curious minds in the fight against aging. Join me as we embark on a fascinating journey into the realm of anti-aging science, exploring Lifespan.io and the cutting-edge discoveries shaping the future of longevity.

Unraveling the Mysteries of Aging:

Before diving into the intricacies of anti-aging research, let's first unravel the mysteries of aging itself. Aging is a complex phenomenon influenced by a myriad of factors, including genetics, lifestyle, and environmental exposures. At its core, aging is characterized by a gradual decline in cellular function and tissue integrity, leading to an increased susceptibility to age-related diseases and ultimately death.

However, aging is not simply an inevitable fate dictated by our genes. Rather, it is a dynamic process shaped by a delicate interplay of biological mechanisms, many of which are now being unraveled by scientists around the globe. From telomere shortening to mitochondrial dysfunction, researchers are uncovering the underlying drivers of aging and exploring innovative strategies to counteract its effects.

Enter Lifespan.io: A Hub for Anti-Aging Innovation

At the forefront of the anti-aging revolution stands Lifespan.io – a pioneering platform dedicated to advancing longevity research through crowdfunding and community engagement. Founded in 2013 by a passionate team of advocates, Lifespan.io serves as a catalyst for groundbreaking research projects aimed at extending healthy lifespan and combating age-related diseases.

One of the key pillars of Lifespan.io's mission is to democratize science by empowering individuals to contribute directly to cutting-edge research initiatives. Through crowdfunding campaigns, supporters can rally behind promising anti-aging projects, providing crucial funding to accelerate progress in the field. From rejuvenating senescent cells to harnessing the power of artificial intelligence in drug discovery, Lifespan.io projects span a diverse array of disciplines, each with the potential to revolutionize our understanding of aging.

But Lifespan.io is more than just a fundraising platform – it's a vibrant community of scientists, advocates, and enthusiasts united by a shared vision of a world without age-related diseases. Through its online forums, webinars, and educational resources, Lifespan.io fosters collaboration and knowledge-sharing, empowering individuals from all walks of life to join the fight against aging.

The Science of Aging Reimagined:

Now, let's delve into the exciting realm of anti-aging science and explore some of the groundbreaking discoveries shaping the future of longevity. From rejuvenating therapies to age-defying interventions, researchers are harnessing the power of innovation to rewrite the narrative of aging.

Cellular Senescence and Rejuvenation:

At the cellular level, aging is closely linked to the accumulation of senescent cells – damaged cells that have ceased to divide and contribute to tissue dysfunction. Targeting these "zombie cells" has emerged as a promising strategy for rejuvenating aging tissues and extending lifespan. Through innovative approaches such as senolytic therapies and genetic engineering, scientists are paving the way for a new era of regenerative medicine, where age-related decline can be reversed at its source.

Telomeres and the Aging Clock:

Telomeres – the protective caps at the ends of chromosomes – play a crucial role in cellular aging and longevity. As telomeres shorten with each cell division, they serve as a molecular clock that regulates the lifespan of cells. By understanding the mechanisms underlying telomere maintenance and degradation, researchers are uncovering novel targets for anti-aging interventions. From telomerase activation to telomere lengthening strategies, the quest to unlock the secrets of telomeres holds immense promise for extending healthy lifespan.

Mitochondria and Metabolic Health:

Mitochondria – the powerhouse of the cell – play a central role in energy production and cellular metabolism. As we age, mitochondrial function declines, leading to an accumulation of oxidative damage and metabolic dysfunction. Restoring mitochondrial health has thus emerged as a key focus of anti-aging research, with potential implications for a wide range of age-related conditions, from neurodegenerative diseases to cardiovascular disorders. From mitochondrial-targeted antioxidants to mitochondrial replacement therapies, scientists are exploring innovative strategies to rejuvenate aging mitochondria and promote healthy aging.

Epigenetics and Aging Clocks:

Beyond the realm of genetics lies the fascinating world of epigenetics – the study of changes in gene expression that occur without alterations to the underlying DNA sequence. Epigenetic modifications play a crucial role in regulating aging-related processes, serving as molecular switches that control gene activity. By deciphering the epigenetic signatures of aging, researchers have developed powerful tools for predicting biological age and assessing the efficacy of anti-aging interventions. From epigenetic clocks to epigenome editing technologies, the field of epigenetics is revolutionizing our understanding of aging and opening new avenues for intervention.

The Road Ahead: Challenges and Opportunities

As we journey deeper into the realm of anti-aging science, it's important to acknowledge the challenges that lie ahead and the opportunities that await us on the road to longevity. From regulatory hurdles to ethical considerations, the path to translating anti-aging discoveries into clinical applications is fraught with obstacles. However, with perseverance, collaboration, and a shared commitment to advancing human health, we have the potential to overcome these challenges and unlock the full promise of longevity research.

In closing, let us embrace the spirit of exploration and discovery as we continue to push the boundaries of what is possible in the quest for eternal youth. Through platforms like Lifespan.io and the tireless efforts of scientists, advocates, and enthusiasts around the globe, we stand poised to usher in a new era of health and vitality for generations to come. Together, let us seize the opportunity to rewrite the story of aging and unlock the fountain of youth for all humanity.

Join us on this extraordinary journey – the future of longevity awaits.

[healthyhabitjournal]

🌟 Dreaming of youth eternal? Discover the natural secret within our DNA! 🧬 Telomere Lengthening is changing the game in anti-aging, offering a path to longevity and vibrant health without the need for expensive treatments. Dive into natural, effective strategies to protect your DNA and unlock a life filled with vitality. Say yes to a healthier, younger you today! #TelomereLengthening #NaturalYouth #HealthyHabitJournal

[drrobertkast]

The Role of Telomeres in Reversing the Aging Process

Dr. Robert Kast practices in Boca Raton, Florida. An experienced and board-certified obstetrician and gynecologist, Dr. Robert Kast maintains an interest in the role of telomeres in reversing the aging process.

Aging is an inescapable part of life. Scientists are exploring whether increasing telomere length can help reduce the aging process. During the DNA replication process, which sustains an organism, the chromosomes might become too short and eventually die.

Each strand of DNA has two ends. The strands can become tangled, frayed, or shortened without protection. A depletion of genetic material contributes to aging. Telomeres protect DNA by forming a cap, similar in principle to the plastic tip found on the end of shoelaces. The protection allows for proper replication during cell division.

To maintain and increase telomere length, scientists use an enzyme known as telomerase. The enzyme telomerase adds to the sequencing process. Telomerase carries its RNA ribonucleoprotein (template), which enables it to elongate telomeres.

Enhancing telomerase ensures that telomeres don’t get too short or die. Scientists suggest that reactivating the telomerase enzyme, which boosts cell replication, might reverse premature aging.

[retorres]

YOUTH BEAUTY BUNDLE REVIEW - {ATTENTION} IS PEAK BLOOM SKINCARE GOOD?- P...

∆YOUTH BEAUTY BUNDLE OFFICIAL WEBSITE: https://bit.ly/3tV3VGa 

Hello, did you know that PEAK BLOOM was founded from an autoimmune disease that accidentally discovered the fountain of youth called the Youth Beauty Bundle, proving that the formula effectively reverses, rebuilds and rejuvenates skin cells against the effects of ageing. If you suffer from the effects of ageing skin, have tried other anti-ageing products that didn't work or only partially worked and have been told that you need surgery and other expensive solutions. You're in the right place, my name is Duda and in this video I'm going to tell you everything you need to know about PEAK BLOOM's powerful Youth Beauty Bundle, so stick around until the end of this video as the last bit of information will be invaluable. My first warning concerns the website, it's essential that you purchase the PEAK BLOOM Youth Beauty Bundle through the official website for your safety and, to help you, I've left the link to the official website in the description of this video and in the comments below. PEAK BLOOM's Youth Beauty Bundle is a treatment that promises to slow down ageing, eliminate expression lines and improve the appearance of your skin, hair and nails. You won't have to worry about fine expression lines or dark spots and discoloration; wrinkles, dry, sensitive, sagging and drooping skin; your skin will be firmer, fine lines will be less visible and your skin will glow with youth and vitality with PEAK BLOOM's Youth Beauty Bundle. The Youth Beauty Bundle's main differentiator is that it has clean, scientifically proven ingredients for the skin and does exactly what it says and better still, through a simple routine. They are not contaminants like other products that result in burning, rashes, peeling skin and everything else that the commercial beauty industry promotes without addressing the cure of the problem. So, if you're a woman who's currently over 35, you know that as you get older you produce less collagen, fewer proteins and the telomeres in your chromosomes shrink, causing ageing. So join hundreds of Peak Bloom super-agents and start looking younger by doing the treatment at home in less than 3 minutes. Very importantly, don't forget to buy Peak Bloom's Youth Beauty Bundle from the official website I've listed in this description and in the comments below to make sure you get the original product.   I really hope I've helped you, that's my purpose, if you liked the information, subscribe to my channel, like it, share it, every week I'll bring you other tips, suggestions, news and valuable information. GOD BLESS!!! 

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∆DOES PEAK BLOOM'S YOUTH BEAUTY BUNDLE WORK? yes, moisturizing from the inside out. Step 1: reverse Step 2: rebuild and Step 3: regenerate ∆DOES PEAK BLOOM'S YOUTH BEAUTY BUNDLE REALLY WORK? yes, the most powerful source of anti-ageing ingredients travel to your body's cells, promoting healthy skin, hair and nails, taking years off your appearance, without knives or needles. 

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∆WHAT ARE THE BENEFITS OF PEAK BLOOM'S YOUTH BEAUTY BUNDLE? Age-reversing beauty blend, anti-ageing formula for a natural, vibrant and youthful appearance, Reduce lines and wrinkles, tighten skin and help visibly reduce lines and wrinkles, Replenishes and gives your skin a radiant glow, Minimizes the appearance of puffiness due to a variety of natural ingredients that will keep your skin healthy to look firmer. 

∆WHERE TO BUY PEAK BLOOM YOUTH BEAUTY BUNDLE? is only sold exclusively through the official website below: https://bit.ly/3tV3VGa 

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∆subscribe to the channel: https://www.youtube.com/channel/UC-jJWnDIeQZ0_DBFc6UCmig 

∆share this video: https://youtu.be/rtrEQ7BvrEk 

∆YOUTH BEAUTY BUNDLE OFFICIAL WEBSITE: https://bit.ly/3tV3VGa #YOUTH BEAUTY BUNDLE REVIEW #{ATTENTION} IS PEAK BLOOM SKINCARE GOOD?#Peak Bloom rejuvenating kit

[drcpanda12]

New Post has been published on https://www.knewtoday.net/aging-gracefully-exploring-the-multifaceted-journey-of-growing-older/

Aging Gracefully: Exploring the Multifaceted Journey of Growing Older

Why does the lifespan of one animal differ from another?

The ages of different species can vary due to a variety of factors, including genetics, environment, and evolutionary history.

Genetics plays a major role in determining lifespan, as certain genes are associated with increased longevity in some species. For example, some species of whales and tortoises have been found to have genes that help repair damaged DNA, which may contribute to their exceptionally long lifespans.

The environment also plays a significant role in determining lifespan. Environmental factors such as diet, climate, and exposure to toxins can all affect an organism’s lifespan. For example, some species of fish have been found to live longer in colder water, while others may be more susceptible to disease or predation in certain environments.

Evolutionary history can also influence lifespan. Species that have evolved to live in challenging environments, such as deserts or deep-sea trenches, may have adaptations that allow them to survive for longer periods of time. Additionally, some species may have evolved to have shorter lifespans as a trade-off for other beneficial traits, such as rapid reproduction or faster growth rates.

Overall, the ages of different species can be influenced by a complex interplay of genetic, environmental, and evolutionary factors.

Important theories on the aging process

There are several important theories on the aging process, including:

Cellular damage theory: This theory proposes that aging is caused by accumulated damage to cells and tissues over time, including DNA damage, oxidative stress, and inflammation. As cells become damaged, they become less efficient and more susceptible to disease, leading to the decline of organ function and ultimately, aging.

Telomere shortening theory: Telomeres are the protective caps at the end of chromosomes that shorten with each cell division. The telomere shortening theory proposes that this shortening process is responsible for aging, as it limits the number of times cells can divide before they become senescent (unable to divide). Over time, this leads to a decline in tissue function and an increased risk of disease.

Hormonal theory: This theory proposes that aging is caused by changes in hormone levels that occur over time, including decreases in growth hormone, testosterone, and estrogen. These changes can lead to a decline in muscle mass, bone density, and other aspects of physical function.

Evolutionary theory: This theory proposes that aging is a result of evolutionary trade-offs between reproduction and survival. In many species, early reproduction is favored over longevity, as it maximizes the number of offspring produced. As a result, genetic changes that increase early reproduction may also lead to a decrease in lifespan.

Caloric restriction theory: This theory proposes that a reduction in caloric intake can increase lifespan by reducing oxidative damage and inflammation. Studies in animals have shown that caloric restriction can increase lifespan by up to 50%, and it is currently being studied as a potential intervention to delay aging in humans.

The latest research on aging

There is a great deal of ongoing research into aging, as scientists seek to better understand the underlying biological processes and develop interventions to slow or reverse the aging process. Some recent areas of research on aging include:

Cellular senescence: Cellular senescence is a process by which cells enter a state of permanent growth arrest, and it has been implicated in many age-related diseases, including cancer, Alzheimer’s disease, and osteoarthritis. Recent research has focused on identifying drugs that can selectively target senescent cells, with promising results in animal models.

Epigenetics: Epigenetics refers to changes in gene expression that occur without changes to the underlying DNA sequence. Recent research has shown that epigenetic changes play a role in aging and age-related diseases, and there is growing interest in developing drugs that can reverse these changes.

Metabolism: Metabolic processes, including mitochondrial function and nutrient-sensing pathways, have been implicated in aging. Recent research has focused on identifying drugs that can modulate these processes, with the goal of extending lifespan and improving healthspan.

Senolytics: Senolytics are drugs that target senescent cells and promote their clearance. Recent research has shown that senolytics can improve outcomes in animal models of age-related diseases, and there is growing interest in developing these drugs for use in humans.

Gene editing: Advances in gene editing technologies such as CRISPR/Cas9 have opened up new avenues for research into aging. Researchers are exploring ways to use gene editing to modify genes involved in aging and age-related diseases, with the goal of developing new therapies.

Overall, research on aging is a rapidly evolving field, and there is great interest in developing new interventions to improve healthspan and extend lifespan.

The latest research on anti-aging

Research on anti-aging is a growing field, as scientists seek to identify interventions that can slow or reverse the aging process. Some recent areas of research on anti-aging include:

Rapamycin: Rapamycin is a drug that has been shown to extend lifespan in a variety of animal models. Recent research has focused on understanding how rapamycin works, with the goal of developing safer and more effective drugs based on this mechanism.

NAD+ precursors: NAD+ is a molecule involved in many cellular processes, including energy metabolism and DNA repair. Levels of NAD+ decline with age, and recent research has focused on identifying compounds that can increase NAD+ levels, such as nicotinamide riboside.

Senolytics: As mentioned earlier, analytics are drugs that target senescent cells and promote their clearance. Recent research has shown that senolytics can improve outcomes in animal models of age-related diseases, and there is growing interest in developing these drugs for use in humans.

Stem cell therapy: Stem cell therapy involves the transplantation of stem cells to replace damaged or aging cells in the body. Recent research has shown that stem cell therapy can improve outcomes in animal models of age-related diseases, and there is interest in developing these therapies for use in humans.

Lifestyle interventions: Lifestyle interventions, such as exercise, calorie restriction, and intermittent fasting, have been shown to have anti-aging effects in animal models and some human studies. Recent research has focused on understanding the mechanisms underlying these effects and developing interventions that can mimic them.

Overall, research on anti-aging is a rapidly evolving field, and there is great interest in developing new interventions to improve healthspan and extend lifespan. However, it is important to note that many of these interventions are still in the early stages of research, and it may be many years before they are available for widespread use.

[stanford--pines]

Ah, I have a page in the journal about rising the dead did you use a similar spell? If you'd take a suggestion, what about just reversing the effects of aging? You can heal people can't you? it might be a tricky thing to do but you would, hypothetically, just need to heal the individual cells before they begin to completely deteriorate. For example, there's an interesting theory that the telomeres tend to shorten with each replication and will stop dividing eventually, so reversing them back to their initial length after some time would fix such an issue. Though, that sounds like quite a hassle and would be more like resetting a dying body rather than true immortality.

Oh no.. I can't believe we've been such complacent fools! Well, if the aliens think they can get away with such a thing they are sorely mistaken. Once I get the materials and funding to do so, I'll pay them a visit.

Before they became a couple

My input on the earlier stage of their relationship based on @honeqq 's married billford au!!

[knewtoday]

Why does the lifespan of one animal differ from another? The ages of different species can vary due to a variety of factors, including genetics, environment, and evolutionary history. Genetics plays a major role in determining lifespan, as certain genes are associated with increased longevity in some species. For example, some species of whales and tortoises have been found to have genes that help repair damaged DNA, which may contribute to their exceptionally long lifespans. The environment also plays a significant role in determining lifespan. Environmental factors such as diet, climate, and exposure to toxins can all affect an organism's lifespan. For example, some species of fish have been found to live longer in colder water, while others may be more susceptible to disease or predation in certain environments. Evolutionary history can also influence lifespan. Species that have evolved to live in challenging environments, such as deserts or deep-sea trenches, may have adaptations that allow them to survive for longer periods of time. Additionally, some species may have evolved to have shorter lifespans as a trade-off for other beneficial traits, such as rapid reproduction or faster growth rates. Overall, the ages of different species can be influenced by a complex interplay of genetic, environmental, and evolutionary factors. Important theories on the aging process There are several important theories on the aging process, including: Cellular damage theory: This theory proposes that aging is caused by accumulated damage to cells and tissues over time, including DNA damage, oxidative stress, and inflammation. As cells become damaged, they become less efficient and more susceptible to disease, leading to the decline of organ function and ultimately, aging. Telomere shortening theory: Telomeres are the protective caps at the end of chromosomes that shorten with each cell division. The telomere shortening theory proposes that this shortening process is responsible for aging, as it limits the number of times cells can divide before they become senescent (unable to divide). Over time, this leads to a decline in tissue function and an increased risk of disease. Hormonal theory: This theory proposes that aging is caused by changes in hormone levels that occur over time, including decreases in growth hormone, testosterone, and estrogen. These changes can lead to a decline in muscle mass, bone density, and other aspects of physical function. Evolutionary theory: This theory proposes that aging is a result of evolutionary trade-offs between reproduction and survival. In many species, early reproduction is favored over longevity, as it maximizes the number of offspring produced. As a result, genetic changes that increase early reproduction may also lead to a decrease in lifespan. Caloric restriction theory: This theory proposes that a reduction in caloric intake can increase lifespan by reducing oxidative damage and inflammation. Studies in animals have shown that caloric restriction can increase lifespan by up to 50%, and it is currently being studied as a potential intervention to delay aging in humans. The latest research on aging There is a great deal of ongoing research into aging, as scientists seek to better understand the underlying biological processes and develop interventions to slow or reverse the aging process. Some recent areas of research on aging include: Cellular senescence: Cellular senescence is a process by which cells enter a state of permanent growth arrest, and it has been implicated in many age-related diseases, including cancer, Alzheimer's disease, and osteoarthritis. Recent research has focused on identifying drugs that can selectively target senescent cells, with promising results in animal models. Epigenetics: Epigenetics refers to changes in gene expression that occur without changes to the underlying DNA sequence. Recent research has shown that epigenetic

changes play a role in aging and age-related diseases, and there is growing interest in developing drugs that can reverse these changes. Metabolism: Metabolic processes, including mitochondrial function and nutrient-sensing pathways, have been implicated in aging. Recent research has focused on identifying drugs that can modulate these processes, with the goal of extending lifespan and improving healthspan. Senolytics: Senolytics are drugs that target senescent cells and promote their clearance. Recent research has shown that senolytics can improve outcomes in animal models of age-related diseases, and there is growing interest in developing these drugs for use in humans. Gene editing: Advances in gene editing technologies such as CRISPR/Cas9 have opened up new avenues for research into aging. Researchers are exploring ways to use gene editing to modify genes involved in aging and age-related diseases, with the goal of developing new therapies. Overall, research on aging is a rapidly evolving field, and there is great interest in developing new interventions to improve healthspan and extend lifespan. The latest research on anti-aging Research on anti-aging is a growing field, as scientists seek to identify interventions that can slow or reverse the aging process. Some recent areas of research on anti-aging include: Rapamycin: Rapamycin is a drug that has been shown to extend lifespan in a variety of animal models. Recent research has focused on understanding how rapamycin works, with the goal of developing safer and more effective drugs based on this mechanism. NAD+ precursors: NAD+ is a molecule involved in many cellular processes, including energy metabolism and DNA repair. Levels of NAD+ decline with age, and recent research has focused on identifying compounds that can increase NAD+ levels, such as nicotinamide riboside. Senolytics: As mentioned earlier, analytics are drugs that target senescent cells and promote their clearance. Recent research has shown that senolytics can improve outcomes in animal models of age-related diseases, and there is growing interest in developing these drugs for use in humans. Stem cell therapy: Stem cell therapy involves the transplantation of stem cells to replace damaged or aging cells in the body. Recent research has shown that stem cell therapy can improve outcomes in animal models of age-related diseases, and there is interest in developing these therapies for use in humans. Lifestyle interventions: Lifestyle interventions, such as exercise, calorie restriction, and intermittent fasting, have been shown to have anti-aging effects in animal models and some human studies. Recent research has focused on understanding the mechanisms underlying these effects and developing interventions that can mimic them. Overall, research on anti-aging is a rapidly evolving field, and there is great interest in developing new interventions to improve healthspan and extend lifespan. However, it is important to note that many of these interventions are still in the early stages of research, and it may be many years before they are available for widespread use.

[inkintheinternet]

Understanding the Dynamics of Aging

By Arjuwan Lakkdawala

Ink in the Internet

When does aging begin? When we are born we start to grow and most scientists agree that growth stops at 20.

"Most people stop growing sometime around the age of 20. By this time, our skeletons have reached their final size, and the growth plates between bones have fused closed. Once that happens, there is no way for the bones to grow anymore. 

The only bones that continue to get larger are the skull and the pelvis. The growth of these two body parts isn’t dramatic, however. Your pelvis might gain an inch in diameter between the ages of 20 and 79, and your skull may get slightly more prominent around the forehead." - Compass: Healthy Aging Guide.

So what happens after we stop growing? In our body we have trillions of cells that work around the clock to try and maintain our health in the best way and keep themselves alive while doing so. How we live, what we eat, exercise, sleep, mental health, and whether we get sick or how many times we get ill, all this and more effects how well our cells can function. 

No two people age the same way, so anti-aging intervention cannot be one size fits all.

There is a field of study called Epigenetics, which says that our behaviour and our environment effect which of our genes get expressed and which get suppressed, and that these changes if negative can lead to poor mental and physical health. 

"Your genes play an important role in your health, but so do your behaviors and environment, such as what you eat and how physically active you are. Epigenetics is the study of how your behaviors and environment can cause changes that affect the way your genes work. Unlike genetic changes, epigenetic changes are reversible and do not change your DNA sequence, but they can change how your body reads a DNA sequence.

Gene expression refers to how often or when proteins are created from the instructions within your genes. While genetic changes can alter which protein is made, epigenetic changes affect gene expression to turn genes “on” and “off.” Since your environment and behaviors, such as diet and exercise, can result in epigenetic changes, it is easy to see the connection between your genes and your behaviors and environment." - CDC

Trillions of cells in our body are interconnected.

"Your body is comprised of trillions of cells, and each one is not only responsible for one or more functions specific to the tissue it resides in, but must also do all the work of keeping itself alive. This includes metabolizing nutrients, getting rid of waste, exchanging signals with other cells and adapting to stress.

The trouble is that every single process and component in each of your cells can be interrupted or damaged. So your cells spend a lot of energy each day preventing, recognizing and fixing those problems." - Ellen Quarles and the Conversation.

What about pregnancy and childbirth, does it accelerate aging?

There are ongoing studies and a study has shown women who got pregnant had shorter telomeres than women who didn't, but another study showed that women in a community in Africa who got pregnant had longer telomeres than other women in their community who hadn't gotten pregnant. So perhaps it is the emotional state and not the pregnancy that effected the telomeres, some women might get stress from society because of the pregnancy, while other women might get supported.

What are telomeres? As we age our telomeres keep getting shorter.

"A telomere is a region of repetitive DNA sequences at the end of a chromosome. Telomeres protect the ends of chromosomes from becoming frayed or tangled. Each time a cell divides, the telomeres become slightly shorter. Eventually, they become so short that the cell can no longer divide successfully, and the cell dies."

There is another point here that scientists are investigating that is cells known as senescent.

"Senescent cells are unique in that they eventually stop multiplying but don’t die off when they should. They instead remain and continue to release chemicals that can trigger inflammation. Like the one moldy piece of fruit that corrupts the entire bowl, a relatively small number of senescent cells can persist and spread inflammation that can damage neighboring cells.

However, not all senescent cells are bad. The molecules and compounds expressed by senescent cells (known as the senescent secretome) play important roles across the lifespan, including in embryonic development, childbirth, and wound healing." - NIH: National Institute on Aging.

Senescent cells can build up in the body as we age and our immune system becomes less sufficient to expel them by a process known as apoptosis. These cells can cause cognitive decline in the brain and a multitude of age-related diseases and complications.

"Investigations are underway to see if senescent skin cells may contribute to sagging and wrinkling, and if senescent cells might also be connected to the cytokine storm of inflammation that makes COVID-19 so deadly for older adults." NIH: National Institute on Aging

When we age our bodies gradually lose the ability to maintain homeostasis.

"Homeostasis reflects the aggregate effect of varied mechanisms that maintain normal physiologic constancy in the face of different extrinsic challenges. Aging is associated with impaired homeostasis, or homeostenosis, in the form of diminished capacity to respond to varied challenges," - McGraw Hill Medical: Access Medicine 

What we eat is one of the best ways to maintain good health, and scientists say which fruits and vegetables are most effective.

"Aging is a complex, multi-factorial process that starts in our cells, resulting in a gradual decline of the larger systems in the body. Scientists have proposed various theories for the reason we age, including mitochondrial dysfunction, inflammation, DNA damage, cell senescence, and telomere reduction." - Inside Tracker: Diana Licalzi, MS, RD, CDCES

Strawberries are said to be very effect against senescent cells.

"Researchers have been studying fisetin, a plant compound, for years for its capacity to act as an antioxidant and reduce inflammation in the body. However, in more recent years, scientists have discovered it also works by killing senescent cells—one of the hallmarks of aging."

The Jellyfish is being studied to understand how it can revert back to larval state and reverse its aging.

"The analysis revealed that T. dohrnii (species of jellyfish) had twice as many copies of the genes associated with DNA repair and protection, which helps producing greater amounts of protective and repairing proteins. Moreover, this jellyfish also had unique mutations which stunted cell division and prevented telomeres (chromosomes’ protective “caps”) from deteriorating,"- Earth.com: Andrei Ionescu

Copyright ©️ Arjuwan Lakkdawala 2023

Arjuwan Lakkdawala is an author and independent journalist. Twitter/Instagram: Spellrainia 

Email: arjuwan.writer@gmail.com 

Sources:

SciTechDaily.com - 8 Anti-Aging Vitamins and Nutrients That Actually Work, Ranked

University at Buffalo - To reverse aging in stem cells, NANOG gene ‘rewires’ metabolic networks - Cory Nealon

NIH - National Human Genome

Research Institute

Center on the Developing Child - Harvard University

NIH - National Library of Medicine - Bilian Jin, Yajun Li, Keith D. Robertson

NIH - National Library of Medicine

JAMA Network Open

JAMA Netw Open. 2022 Jul; 5(7): e2223285. 

Published online 2022 Jul 27. doi: 10.1001/jamanetworkopen.2022.23285

PMCID: PMC9331104

PMID: 35895062

Analysis of Epigenetic Age Acceleration and Healthy Longevity Among Older US Women

Purva Jain, PhD, MPH, 1 Alexandra M. Binder, ScD, ScM, 2 , 3 Brian Chen, PhD, 1 Humberto Parada, Jr, PhD, MPH, 4 , 5 Linda C. Gallo, PhD, 4 John Alcaraz, PhD, 5 Steve Horvath, PhD, ScD, 6 , 7 Parveen Bhatti, PhD, 8 Eric A. Whitsel, MD, MPH, 9 , 10 Kristina Jordahl, PhD, 11 Andrea A. Baccarelli, MD, PhD, 12 Lifang Hou, MD, PhD, 13 James D. Stewart, PhD, 9 , 10 Yun Li, PhD, 14 , 15 , 16 Jamie N. Justice, PhD, MS, 17 and Andrea Z. LaCroix, PhD 1

University of Nebraska System - Aging starts right after growing ends - Sabine Zempleni and Sydney Christensen

Compass by WebMd - What to Know About Nose and Ear Growth as You Age

 Written by WebMD Editorial Contributors

Reviewed by Dan Brennan, MD on November 01, 2021

The Washington Post- Do pregnancy and childbirth accelerate aging in women? Maybe.

By Sindya Bhanoo

NIH - National Institute on Aging - 10 myths about aging

NIH - National Institute on Aging- understanding the dynamics of the aging process