#reverse aging telomeres

[shiut]

Homunculus Research (the kinda scientific edition)

Time for me to do the thing that I do where I think way too much about barely explained fictional science and try my best to apply actual science to it. For fun.

So, here is my biological summary for the homunculi of Rain Code, which will be mostly non-canon speculation.

What is a homunculus? A homunculus is an artificially created, cloned individual using the genetic information of a human for the purpose of developing immortality and regeneration applicable to military use.

What is a homunculus made of and how? A homunculus is created from gram-negative bacteria and human cells through complete recombinant DNA cloning. This technique is achieved through taking the genes of the human donor and incorporating the information into a bacterial chromosomal DNA and plasmid(the secondary circular DNA molecule of bacteria used for gene replication and transfer). Additionally, the incorporation of the enzyme telomerase and protein p53 is applied.

What contributes to a homunculus's regenerative properties and immortality? Homunculi exhibit accelerated initial growth and healing thanks to the bacterial hybridization of their cells. Bacteria have one of the fastest replication rates, and can replicate at a rate of about every 10 minutes compared to the average human cell's replication rate of every 24 hours. Gram-negative bacteria also have a complex layering of membrane that allow them to be more resistant to antibiotics and a more sturdy structure. Bacteria have the ability to go through inactivation, where they go into a state of metabolic dormancy that protect them and allow them to be able to wait out periods of extreme conditions and nutrient scarcity. Telomerase, the 'immortality enzyme', is utilized for its function in restoring the length of telomeres. Telomeres are a protective chromosomal cap that normally erode with each cell division, and it's this shortening that causes DNA damage and aging in humans. Telomerase repairs this erosion and allows cells to divide indefinitely. However, because of telomerase's link to increased rates of cancer, additional copies of the gene responsible for the production of p53 protein is also incorporated. P53 is a tumor suppressor that allows damaged cells to repair themselves before dividing, which prevents the spread of cancerous cells.

Why is homunculus blood pink? Gram-negative bacteria is identifiable for its bright pink color by using the gram staining method. This is because the characteristic cell wall structure of gram-negative bacteria which makes them so resilient also causes the bacteria to display the color of the safranin. Homunculus researchers may apply a gram staining process to the circulatory system of homunculi for the purpose of identification and observation.

Relevance of gram-negative bacteria in gene cloning and military research. The most commonly used strain of bacteria used in gene cloning research is the gram-negative bacteria such as e. coli for its ready availability, ease of growth and manipulation, and simplicity. Gram-negative bacteria such as e. coli has a history in military research, in cases such as a probiotic when an army surgeon isolated a strain found in a soldier who, unlike his comrades, did not develop an illness from an infectious outbreak.

What is the zombified state of imperfect homunculi? It is the result of cell inactivation that, while it is a protective measure for the cells, the slowed or halted metabolic state causes the low-functioning mental and physical faculties that present zombie-like symptoms, and is currently difficult to impossible to reverse in imperfect homunculi due to their varying degrees of cellular instability.

Why do imperfect homunculi require compounds found in human flesh for nutrients? Plasmid stability in DNA cloned cells is often influenced by the original donor's genotype. Imperfect homunculi cells may include defects in the cell division process where the stability of the human DNA contained in the cell plasmid results in incomplete DNA replication, whereas each division causes informational gaps in the gene and interrupt protein synthesis. These gaps can be filled and repaired by taking and incorporating the required information from a healthy human cell through the process of horizontal gene transfer. Human matter must be consumed and broken down in order for the homunculus cells to initiate this process. The lack of these nutrients can cause the homunculus cells to go into a state of inactivation.

Why are imperfect homunculi vulnerable to sunlight? UV has been known to exhibit antimicrobial effects. Many bacteria, especially gram-negative bacteria, are averse to sunlight. Exposure to the UV radiation in sunlight results in the damage or solar induced inactivation of unstable homunculus cells.

Written, hopefully, as simplified and concise as possible for readability. I feel like I'm forgetting more things I wanted to address, but maybe I'll just leave it here and just make more parts if I think of it :P

[metamatar]

This project is not something a researcher would ever write a grant proposal for. It’s an exploration that threatens to reverse an entrenched idea—that T cells have an intrinsically limited capacity to fight—with no guarantee of success. “It’s almost a historically monumental experiment to do. No one does an experiment that lasts 10 years,” says Wherry. “It’s antithetical to funding mechanisms, and a five-year funding cycle—which really means every three years you have to be doing something new. It’s antithetical to the way we train our students and postdocs who typically are in a lab for four or five years. It’s antithetical to the short attention span of scientists and the scientific environment we live in. So it really says something fundamental about really, really wanting to address a critically important question.”

Indeed, the project remained unfunded for the first eight years, surviving just on lab members’ spare time. But its central question was ambitious: Must immune cells age? In 1961, microbiologist Leonard Hayflick argued that all of our cells (except eggs, sperm, and cancer) could only divide a finite number of times. In the 1980s, researchers advanced the idea that this might play out through the erosion of protective telomeres—a sort of aglet at the end of chromosomes—which shorten when cells divide. After enough divisions, there’s no more telomere left to protect the genes.

This project challenged the Hayflick limit.

[kleptomatic]

ok so i looked this up

But this is a much better source i think because its closer to when the experiment was done and it has quotes from him. Also it has a very interesting section on, in his words, how difficult it would be to "propagate the species" underwater.

He says that hyperbaric conditions increase stem cells, collagen, and telomere length.

There is this 2020 study on hyperbaric environments increasing telomere length. Telomeres are part of DNA and degrade over time. The rate at which they degrade primarily helps determines lifespan, length secondarily helps determine lifespan (this is highly simplified, definitely research it on your own if you want. wikipedia article linked)

so, lengthening telomeres/how fast they degrade can slow down aging and possibly increase lifespan

(hyperbaric = higher pressure)

"In conclusion, the study indicates that HBOT may induce significant senolytic effects including significantly increasing telomere length and clearance of senescent cells in the aging populations."

Senolytics is the field of research that deals with delaying/reversing/preventing aging.

So, high-pressure oxygen therapy may create effects that help reverse agin. This includes lengthening telomeres and getting rid of cells that don't divide anymore.

Essentially, until is conclusively proven that lengthening telomeres will decrease the effects of aging, as length isn't the only factor that affects aging, all we can really prove from this is that spending 93 days underwater let this guy lengthen his telomeres to the level they would have been at approximately 10 years ago.

Overall though, dude seems chill. Would want to take his course, even if he's not underwater.

Ok

[praneeth8373733]

Exploring Anti-Ageing Innovations for a Healthier, Longer Life

The quest for eternal youth and longevity has been a part of human culture for centuries. From ancient alchemists seeking the "elixir of life" to modern science unlocking the genetic code, the desire to combat the effects of ageing is as old as civilization itself. Today, advancements in technology, medicine, and genetics are driving new anti-ageing innovations that promise a healthier, longer life. Let’s explore some of the most exciting and promising developments in the field of anti-ageing.

Genetic Research and Anti-Ageing One of the most groundbreaking areas of anti-ageing research is genetic science. Over the past few decades, scientists have uncovered fascinating insights into how our genes influence the ageing process. One of the most significant breakthroughs is the discovery of the "longevity gene" — a gene that, when activated, may slow down the ageing process and extend lifespan.

Researchers are also exploring ways to manipulate genes responsible for cellular repair and regeneration. For example, the study of telomeres — the protective caps at the end of chromosomes — has revealed that as telomeres shorten over time, cells lose their ability to divide and regenerate. Scientists are now working on ways to extend the length of telomeres, which could lead to healthier, more youthful cells and a longer life.

Stem Cell Therapy Stem cell therapy is another innovative approach gaining attention in the field of anti-ageing. Stem cells are unique because they have the ability to develop into different types of cells in the body, potentially repairing or replacing damaged tissues. In the context of ageing, stem cell therapy holds promise for rejuvenating organs, tissues, and even the skin.

For instance, stem cell injections have been shown to promote the regeneration of skin cells, improving the appearance of wrinkles and sagging skin. In more severe cases, stem cells are being explored for use in regenerating damaged organs, offering hope for reversing age-related diseases like heart disease and Alzheimer’s.

Senolytics: Targeting Senescent Cells Another exciting area of research involves senolytics, which are compounds designed to target and eliminate senescent cells. These are cells that have stopped dividing and accumulating in the body as we age, often contributing to chronic inflammation, tissue damage, and age-related diseases.

By removing these cells, researchers believe they can help restore tissue function and reduce the physical and mental effects of ageing. Early studies on senolytic drugs have shown promising results, including the potential to reduce frailty, improve muscle strength, and even extend lifespan.

Regenerative Medicine and Organ Transplants Advancements in regenerative medicine are offering new solutions to combat the effects of ageing. The ability to grow organs in laboratories or use 3D printing to create tissue replacements could revolutionize the way we address age-related decline. Rather than relying on traditional organ transplants, scientists envision creating custom-grown organs that could replace failing ones, offering patients the chance to live longer, healthier lives.

Moreover, regenerative therapies are being applied to skin care as well. From bioengineered skin grafts to the use of growth factors that stimulate collagen production, these innovations aim to combat wrinkles and skin damage, making us look as young as we feel.

Nutraceuticals and Anti-Ageing Supplements The rise of nutraceuticals, or food-based supplements, has also contributed to the growing field of anti-ageing. These supplements are packed with ingredients designed to target the biological processes of ageing. Some popular ingredients include resveratrol, NAD+ boosters, and curcumin — all known for their anti-inflammatory and antioxidant properties.

By taking these supplements, individuals may be able to reduce oxidative stress and inflammation, which are major contributors to the ageing process. While research is still ongoing, many people are already incorporating these anti-ageing supplements into their daily routines in hopes of living longer, healthier lives.

Conclusion The innovations in anti-ageing research are promising and continuously evolving, offering exciting possibilities for those who seek to live longer and healthier lives. From genetic breakthroughs to stem cell therapies and regenerative medicine, these cutting-edge developments are pushing the boundaries of what was once considered impossible. As science continues to advance, the future of anti-ageing may hold solutions that will not only add years to our lives but enhance the quality of those years as well.

This article covers various innovative approaches in anti-ageing and longevity, providing an overview of the most promising developments in the field.

[nithish7841]

The Fountain of Youth: Exploring Anti-Ageing and Longevity Strategies

In a world where time is constantly moving forward, the desire to preserve youth and live longer has always been a fundamental part of human nature. The concept of anti-ageing and longevity has captured the imaginations of many, inspiring scientific discoveries, medical breakthroughs, and lifestyle changes. In this exploration of anti-ageing and longevity strategies, we dive into the science, methods, and practices that promise to not only slow the aging process but potentially extend human lifespan.

The Science Behind Anti-Ageing and Longevity Anti-ageing is more than just about vanity or slowing down the appearance of wrinkles and fine lines. It is the scientific pursuit of extending the healthy and productive years of life. At its core, anti-ageing involves understanding the biological processes that cause cells, tissues, and organs to deteriorate over time. Researchers have discovered several key processes involved in ageing, such as oxidative stress, DNA damage, cellular senescence, and inflammation. These contribute to the development of age-related diseases and the breakdown of bodily functions.

One of the most significant advancements in anti-ageing science is the understanding of telomeres. Telomeres are the protective caps at the ends of chromosomes, which shorten with each cell division. When telomeres become too short, cells can no longer divide and die, leading to tissue dysfunction. Research has shown that by maintaining or even lengthening telomeres, it may be possible to delay the effects of ageing. Telomere extension, while still under investigation, represents one promising strategy for anti-ageing and longevity.

Dietary Interventions and Longevity One of the most accessible ways to impact longevity is through diet. Certain dietary patterns have been shown to have a significant effect on the aging process. Caloric restriction, for instance, has been linked to increased lifespan in several animal models, and some believe it might extend human life as well. Studies suggest that reducing calorie intake without malnutrition can slow down metabolic processes and decrease the incidence of age-related diseases.

Additionally, the Mediterranean diet, rich in healthy fats from olive oil, fresh fruits, vegetables, and lean proteins like fish, has been associated with lower levels of inflammation and better cardiovascular health—factors that contribute to longevity. Moreover, intermittent fasting has gained popularity for its potential to improve cellular repair processes and activate longevity genes, such as sirtuins, which are believed to protect cells from damage.

Physical Activity and Anti-Ageing Exercise plays a crucial role in combating ageing. Regular physical activity not only maintains muscle mass and strength, but it also helps improve heart health, metabolism, and brain function. Aerobic exercise, strength training, and flexibility exercises have all been shown to slow down the signs of aging and improve overall quality of life.

One of the key benefits of physical activity in anti-ageing is its effect on the body's ability to manage oxidative stress, which can cause cellular damage. Exercise encourages the production of antioxidants within the body, helping to neutralize free radicals that accelerate ageing. Additionally, exercise increases the production of growth factors like brain-derived neurotrophic factor (BDNF), which supports brain health and cognitive function as we age.

Innovative Therapies and Anti-Ageing Treatments Beyond lifestyle interventions, cutting-edge therapies are pushing the boundaries of anti-ageing and longevity. Stem cell therapy, for instance, holds potential for rejuvenating damaged tissues and organs. By introducing new, young stem cells into the body, researchers hope to regenerate organs, repair damaged DNA, and reverse some signs of ageing. Gene editing technologies like CRISPR-Cas9 also show promise in targeting genes responsible for aging, potentially offering a way to alter the genetic code in a way that extends life.

Hormone replacement therapies and treatments like NAD+ boosters aim to restore youthful vigor by addressing the hormonal imbalances and cellular dysfunctions that occur with age. These innovative treatments are still in their early stages but show exciting promise for the future.

Conclusion The pursuit of anti-ageing and longevity is an exciting field of research that combines science, innovation, and lifestyle changes to help individuals live longer, healthier lives. While there is no single fountain of youth, a combination of factors—such as a healthy diet, regular exercise, cutting-edge medical treatments, and a focus on overall well-being—can significantly improve the quality of life and increase longevity. As scientific research continues to evolve, we may be closer than ever to unlocking the secret to a longer, more vibrant life.

[doctor-silvair]

A Brief Thesis Overview on Obtaining Lasting Life, Beauty and Health

I. Introduction

The quest for improved longevity, aesthetic appeal, and optimal health has driven humanity towards various methods of body enhancement.

This thesis provides a comprehensive overview of possible methods to enhance the human body without ethical constraints, focusing on surgical, nutritional, physical, genetic, psychological, and technological, interventions.

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II. Surgical Methods

Surgery remains one of the most direct and effective ways to enhance physical appearance and health.

Cosmetic Surgery: Procedures like facelifts, liposuction, and breast augmentation enhance beauty by reshaping body features to conform to cultural standards of attractiveness.

Anti-Aging Procedures: Botox injections and dermal fillers temporarily reduce the appearance of wrinkles, providing a more youthful look.

Reconstructive Surgery: Organ transplants and limb replacements restore function and improve the quality of life, contributing to overall health.

Hormonal Replacement Therapy (HRT): Administering testosterone, estrogen, and progesterone can reverse some effects of aging and promote vitality.

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III. Dietary and Nutritional Methods

Diet plays a crucial role in enhancing health and aesthetics.

Caloric Restriction: Reducing caloric intake has been linked to longevity due to its effect on metabolic rate and cellular repair.

The Bulletproof Diet: Developed by Dave Asprey, this diet emphasizes high-quality fats, moderate protein, and low carbohydrates, aimed at improving energy and focus.

Intermittent Fasting: This method fosters autophagy, a process that clears damaged cells, potentially extending life.

Supplements: Anti-aging compounds like resveratrol and NMN, along with essential vitamins, can support health at a cellular level.

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IV. Physical Enhancement Methods

Physical fitness is essential for maintaining youth and health.

Exercise Regimens: Resistance training and HIIT are proven methods to enhance physical capabilities and prevent age-related decline.

Biohacking with Wearable Technology: Devices monitoring heart rate variability and sleep can optimize health practices.

Advanced Recovery Techniques: Cryotherapy and infrared saunas can enhance recovery, reduce inflammation, and promote well-being.

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V. Genetic and Cellular Modifications

Advancements in genetics offer groundbreaking methods for enhancement.

CRISPR Technology: This allows for precise gene editing, providing potential for eradicating genetic diseases and enhancing resilience.

Stem Cell Therapy: Regenerative medicine utilizes stem cells to repair damaged tissues, contributing to longevity and improved health.

Telomere Extension Techniques: Research into extending telomeres suggests a method for reversing aging processes at the cellular level.

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VI. Mind-Body Enhancement Methods

Mental health and cognitive function significantly impact overall well-being.

Meditation and Mindfulness: Practicing these techniques has been associated with reduced stress, improved mental health, and extended lifespan.

Neurofeedback: This method provides real-time data on brain activity, allowing for cognitive enhancements.

Psychopharmacology: The use of smart drugs (nootropics) can enhance cognitive function, memory, and mental clarity.

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VII. Technological Advancements

Innovative technologies are reshaping body enhancement.

Wearable Technology: Health-monitoring devices track vital signs and promote health-awareness.

Nanotechnology: Applications in medicine, such as targeted drug delivery systems, can vastly improve treatment efficacy.

Virtual Reality: This technology offers stress reduction and mental health benefits, enhancing overall well-being.

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VIII. Other Options

A few other options comes to mind as well, although they may be frowned upon by the less open-minded.

Genetic Cloning: The possibility of creating genetically identical individuals raises significant enhancement prospects.

Cybernetic Enhancements: Brain-computer interfaces could lead to cognitive augmentations and expanded capabilities.

Performance-Enhancing Drugs (PEDs): The use of anabolic steroids and other substances can significantly enhance physical performance. However, more research is needed to learn whether these is beneficial or detrimental to heal in the long run, and what a potential safe dosage would be.

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IX. Conclusion

The methods to enhance the human body span a wide range of categories, each with its own implications for longevity, beauty, and health.

As society progresses, further research is needed to explore these options thoroughly and responsibly, as they hold the potential to redefine the human experience.

The pursuit of these enhancements invites an ongoing dialogue about the future of human health and well-being, while the quest for beauty and longevity continues unabated.

[cashewcashew]

i was obsessed with the molecular bio / epigenetics approach to stopping/reversing aging for a bit and unfortunately it likely will not be a thing in any of our lifetimes due to just how much goes into it.

between telomeres and removing stress induced epigenetic stuff and a whole host of other factors, science just doesn’t move THAT quick to make reversing aging a possibility in the next 7-10 decades.

that dental regeneration stuff looks hype though i’m very excited to see that come to fruition since it’s far more feasible with current stem cell tech (assuming legal/ethical barriers don’t hold it back)

[adrielcloud]

Rethinking Death Through Regeneration and Resurrection Ecology

The history of the world, as natural history, is nothing more than a stratification of events and processes that are never definitively ‘dead and buried’, but which continue to flow and exert an active force from a lower, or even subterranean, dimension than the present—events and processes that can also reappear in an altered form, upsetting our temporal perception. This characteristic pluriversality amounts to the preeminence of reality over imagination, i.e. the hierarchical superiority of natural processes over thought. 

- Chapter ‘For a chaotic vision of time’, Gruppo di Nun, Revolutionary Demonology

Death in secular societies is often viewed as the ultimate, irreversible conclusion to life. This perception is deeply rooted in our understanding of human biological mortality, where once the brain stops functioning and the heart ceases to beat, life is considered to be over, with no continuation beyond the bodily processes. This perspective is not universal, it's profoundly influenced by cultural, religious, and philosophical belief systems that offer different interpretations of what happens after the physical body ceases to function. In many spiritual and religious traditions death is not seen as the end of life but rather a transition to a different form of existence. For those who believe in reincarnation the end of the physical body does not signify the end, instead it is believed that the soul after leaving the body is reborn into a new one, continuing its journey through successive lives. This cyclical view of life and death suggests that death is merely a passage from one form of life to another, rather than an absolute conclusion.

The idea that human life can be prolonged, renewed, or even reanimated has been portrayed in diverse and evolving ways, from the pages of early science fiction to the screens of modern cinema, and increasingly within scientific laboratories. These portrayals reflect humanity’s enduring fascination with mortality and the relentless pursuit of ways to transcend it.  

Real-world efforts by the biotech industry pursue the reversal of ageing and, by extension, death itself. Peter Thiel, the tech billionaire known for his ventures into disruptive technologies, is one of the prominent figures leading the charge against growing old. His investments in biotech firms that focus on anti-aging research aim to challenge the inevitability of death by targeting the biological processes that cause ageing. Thiel and other tech entrepreneurs are exploring various avenues, from cellular reprogramming to extending telomeres—the protective caps on chromosomes that shorten with age. These efforts are rooted in the belief that ageing is a disease that can be cured and that, by doing so, the human lifespan can be dramatically extended, potentially leading to a future where death is no longer an unavoidable fate.

Immortality finds parallels in nature, where certain organisms possess regenerative abilities that defy the typical constraints of life and death. The immortal jellyfish (Turritopsis dohrnii), for instance, can revert to its immature polyp stage after reaching adulthood, effectively resetting its biological clock. This form of biological immortality allows the jellyfish to escape death, at least theoretically, by continuously cycling between life stages. Such natural examples of regeneration challenge our human-centric understanding of mortality, suggesting that life can persist in forms we barely understand.

Resurrection Ecology, which studies species that can revive after long periods of dormancy is an example of how life adapts and persists through extreme environmental conditions. This fascinating field studies the potential for ecosystems to recover or "resurrect" from extreme disturbances by analysing ancient organisms and their genetic material. A notable example involves the freshwater crustacean Daphnia, which can produce eggs that remain dormant in sediments for decades or even centuries. When environmental conditions become favourable again, these eggs can hatch, effectively resurrecting a population that had seemingly vanished. This process not only illustrates the resilience of certain species but also provides valuable insights into how ecosystems might regenerate after severe disruptions, such as climate change or human-induced environmental damage.

The state of the natural world is one of "pluriversality," where even buried processes exert their influence across time, suggesting that nature operates with a chaotic, layered temporality, where the past re-emerges in altered forms, reshaping the present.

Cryptobiosis (literally meaning hidden life), is where the metabolic rate of an organism is reduced to an imperceptible level, showing no visible signs of life.' Cryptobiosis includes anhydrobiosis (life without water), cryobiosis (life at low temperatures), and anoxybiosis (life without oxygen). In the cryptobiotic state, all metabolic procedures stop, preventing reproduction, development, and repair where an organism can live almost indefinitely while it waits for environmental conditions to become better.

Within the human body, certain tissues and organs possess a remarkable ability to regenerate. The liver, for example, can recover from substantial damage by regenerating its lost tissue, a phenomenon that was mythologized in the story of Prometheus. Chained to a rock, Prometheus’s liver was eaten by an eagle each day, only to regenerate by night—a tale that ancient Greeks may have used to symbolise the resilience of this vital organ. Modern science confirms that the liver’s regenerative capacity is indeed exceptional, but it also highlights the limits of human regeneration. While some tissues like the endometrium and fingertips can regenerate to some extent, the loss of limbs or severe damage to the brain remains beyond our bodily capacity to repair.

Scientists are exploring ways to harness the body’s own regenerative mechanisms or induce regeneration in tissues that typically do not regenerate. The goal is to develop therapies that can restore lost or damaged tissues, effectively turning back the biological clock on a cellular level. 

Axolotls are remarkable for their ability to regenerate lost or damaged body parts, which has long fascinated scientists, particular for stem cell research. Beyond limbs, axolotls can regenerate vital organs like the heart, lungs, and even segments of their spinal cord, restoring function. They can also regenerate parts of their brain and eyes, something highly unusual in vertebrates. Unlike most animals, they heal without scarring, maintaining the full functionality of the regenerated tissue. This regenerative ability holds potential for human medicine, if researchers can unlock the genetic and cellular processes enabling axolotl regeneration, it might one day be possible to apply these insights to humans. This could revolutionise treatments for injuries like spinal cord damage, heart disease, or limb loss.

These ideas challenge our Western notions of life and death. Traditionally viewed as a final, irreversible state, death can instead be reimagined as a transitional phase—one that contains the potential for the (re)emergence of life, or perhaps that which never dies.

[lexical-lushes]

[Emily] one aspect is healthspan.

aging /is/, in fact, a process of degradation, at least in a biological sense - most of the detrimental effects we associate with old age are a result of the biological processes that keep our bodies repaired slowly breaking down due to things like telomere shortening (the process in which your genes replicating very gradually wears down their genetic code and can eventually cause replication errors and cell death).

so past a certain point, your body starts to wear out from under you - your motor function degrades, your body gets stiffer, maybe your mind starts to go... and then if you fall and break a hip that's potentially lethal, or your heart gives out because its physical structure has grown too weak, or you have a fatal stroke, or whatever.

so anti-aging treatments are about reversing or stalling this degradation so that your body remains healthy and functional longer.

potentially living to 100 doesn't do much good if the last 25-50 years are miserable because your body is falling apart.

"aging is fascism" is an undeniably dumb take, but like... the underlying point of "we can or soon will be able to prevent the detrimental effects of aging and this is a good thing" isn't actually wrong.

this isn't about "trying to stop linear time", it's about healthcare. we have biological clocks in all our cells that are counting down until the days that sickness and ill-health become increasingly inevitable - shouldn't we try to stop or at least slow them?

scrunching my face real hard rn

[allthenewzworld]

A Florida scientist who spent 100 days underwater claims to still experience some health benefits nine months after returning to land.

Retired Navy diver Joseph Dituri spent this record-breaking time in a bunker 30 feet below the Atlantic Ocean's surface, in a high-pressure environment he credits with reversing his body's age on a cellular level.

Upon emerging in June of last year, Dituri reported blood tests showing a 50% reduction in all inflammatory markers, a 17-fold increase in stem cells, and longer telomeres-structures on chromosomes believed to be linked to life extension.

Read more at link in our bio.

#news #scientist #underwater #record #newrecord #allthenewz

[openintegrative]

DNA & Longevity: Can You Live to 200?

Longevity is shaped by a mix of genetics and lifestyle.

Certain genes are linked to longer lifespans.

Lifestyle choices can influence how long you live.

Science suggests living to 200 may be possible, but there are challenges.

Understanding your DNA can help you make choices for a longer life.

Introduction

The idea of living to 200 years old sparks curiosity and ambition. While many factors contribute to how long we live, genetics plays a significant part.

We can explore what might be possible in extending human life by understanding the role of DNA in longevity.

The Science of Longevity

Genetics strongly impacts how long we live. Certain genes, like SIRT1, FOXO3, and IGF-1, are linked to longer lifespans.

Telomeres, which protect our chromosomes, also play a key part in determining lifespan. As they shorten, cells age, leading to aging in the body.

Potential for Living to 200

Current science explores the limits of human lifespan. Research on people who live past 100, known as centenarians, and those who live past 110, known as supercentenarians, provides insights into how long humans might live.

With advancements in technology and understanding, living to 200 could become a reality, though it remains a significant challenge.

Genetic Factors Affecting Longevity

Genetic variations can slow down aging processes. Some people naturally have mutations that help their bodies repair DNA more effectively, which could contribute to a longer life.

Understanding these genetic factors gives us a better picture of what might be possible in extending lifespan.

Lifestyle and Environmental Influences

Your environment and lifestyle heavily influence your longevity. Diet, exercise, and other habits can either support or hinder your genetic potential for a long life.

Make metabolic health a top priority by balancing key minerals, especially copper and magnesium, and optimizing important enzymes like ceruloplasmin and superoxide dismutase.

Efforts should be made to prevent iron dysregulation. When iron accumulates in cells, it can catalyze the formation of free radicals, leading to damage of proteins, fats, and DNA.

You can maximize your chances of living longer by making healthy choices even if your genes aren’t perfect.

Future of Longevity Research

The future of longevity lies in advancements like gene therapy and CRISPR technology. Scientists are also exploring anti-aging drugs and other treatments that could slow or reverse aging.

As this research progresses, we might get closer to the possibility of living much longer lives. However, ethical questions arise as we consider the implications of such advances.

Challenges and Limitations

While the idea of living to 200 is intriguing, there are many challenges. Biological limits, societal impacts, and the potential downsides of extreme longevity all come into play.

It’s important to balance the desire for a longer life with the need for a high quality of life.

Conclusion

Living to 200 years old might be within reach, but it requires a deep understanding of genetics, lifestyle, and emerging technologies. While the future holds promise, focusing on healthy living now remains the best approach to a longer, healthier life.

FAQ

What genes are most associated with long life? Genes like SIRT1, FOXO3, and IGF-1 are closely linked to longevity.

How does lifestyle interact with genetics to affect lifespan? Lifestyle choices like diet and exercise can enhance or limit your genetic potential for a long life.

Is it realistic to expect humans to live to 200 years? While theoretically possible, significant scientific and ethical challenges must be addressed.

What are the ethical implications of significantly extending human life? Extending life raises questions about resource use, societal impacts, and quality of life.

How can current genetic technology help in achieving longer lifespans? Advances in gene therapy and CRISPR may offer ways to slow aging and extend life.

Research

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Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993). Oxidants, antioxidants, and the degenerative diseases of aging. Proceedings of the National Academy of Sciences of the United States of America, 90(17), 7915-7922. https://doi.org/10.1073/pnas.90.17.7915

Ashraf, A., Clark, M., & So, P. (2018). The Aging of Iron Man. Frontiers in Aging Neuroscience, 10, 344384. https://doi.org/10.3389/fnagi.2018.00065

Azzi, A., Davies, K.J.A. and Kelly, F., 2004. Free radical biology – terminology and critical thinking. FEBS Letters, [online] 558(1–3), pp.3–6. https://doi.org/10.1016/s0014-5793(03)01526-6.

Beckman, K.B. and Ames, B.N., 1997. Oxidative Decay of DNA. Journal of Biological Chemistry, [online] 272(32), pp.19633–19636. https://doi.org/10.1074/jbc.272.32.19633.

BECKMAN, K.B. and AMES, B.N., 1998. The Free Radical Theory of Aging Matures. Physiological Reviews, [online] 78(2), pp.547–581. https://doi.org/10.1152/physrev.1998.78.2.547.

Chen, W.J., Kung, G.P. and Gnana-Prakasam, J.P., 2022. Role of Iron in Aging Related Diseases. Antioxidants, [online] 11(5), p.865. https://doi.org/10.3390/antiox11050865.

Darnell, J.E., Lodish, H.F. and Baltimore, D., 1986. Molecular cell biology. Springer.

Frei, B., Forte, T.M., Ames, B.N. and Cross, C.E., 1991. Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid. Biochemical Journal, [online] 277(1), pp.133–138. https://doi.org/10.1042/bj2770133.

Galaris, D., Mantzaris, M. and Amorgianiotis, C., 2008. Oxidative stress and aging: the potential role of iron. Hormones, [online] 7(2), pp.114–122. https://doi.org/10.1007/bf03401502.

Harman D. The aging process. Proc Natl Acad Sci U S A. 1981 Nov;78(11):7124-8. doi: 10.1073/pnas.78.11.7124. PMID: 6947277; PMCID: PMC349208.

Harman, D., 1969. PROLONGATION OF LIFE: ROLE OF FREE RADICAL REACTIONS IN AGING. Journal of the American Geriatrics Society, [online] 17(8), pp.721–735. https://doi.org/10.1111/j.1532-5415.1969.tb02286.x.

Meneghini, R. (1997). Iron Homeostasis, Oxidative Stress, and DNA Damage. Free Radical Biology and Medicine, 23(5), 783-792. https://doi.org/10.1016/S0891-5849(97)00016-6

Pellowski, D., Heinze, T., Tuchtenhagen, M., Müller, S.M., Meyer, S., Maares, M., Gerbracht, C., Wernicke, C., Haase, H., Kipp, A.P., Grune, T., Pfeiffer, A.F.H., Mai, K. and Schwerdtle, T., 2024. Fostering healthy aging through selective nutrition: A long-term comparison of two dietary patterns and their holistic impact on mineral status in middle-aged individuals—A randomized controlled intervention trial in Germany. Journal of Trace Elements in Medicine and Biology, [online] 84, p.127462. https://doi.org/10.1016/j.jtemb.2024.127462.

Pouillot A, Polla A, Polla BS. Iron and iron chelators: a review on potential effects on skin aging. Curr Aging Sci. 2013 Dec;6(3):225-31. doi: 10.2174/18746098112059990037. PMID: 23866012.

Rattan, S.I.S., 2006. Theories of biological aging: Genes, proteins, and free radicals. Free Radical Research, [online] 40(12), pp.1230–1238. https://doi.org/10.1080/10715760600911303.

Richter, C., Park, J.W. and Ames, B.N., 1988. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proceedings of the National Academy of Sciences, [online] 85(17), pp.6465–6467. https://doi.org/10.1073/pnas.85.17.6465.

Sohal, R.S. and Weindruch, R., 1996. Oxidative Stress, Caloric Restriction, and Aging. Science, [online] 273(5271), pp.59–63. https://doi.org/10.1126/science.273.5271.59.

Tian, Y., Tian, Y., Yuan, Z., Zeng, Y., Wang, S., Fan, X., Yang, D. and Yang, M., 2022. Iron Metabolism in Aging and Age-Related Diseases. International Journal of Molecular Sciences, [online] 23(7), p.3612. https://doi.org/10.3390/ijms23073612.

Waiter, P.B., Beckman, K.B. and Ames, B.N., 1999. The role of iron and mitochondria in aging. OXIDATIVE STRESS AND DISEASE, 2, pp.203-228.

Xu, J., Marzetti, E., Seo, A.Y., Kim, J.-S., Prolla, T.A. and Leeuwenburgh, C., 2010. The emerging role of iron dyshomeostasis in the mitochondrial decay of aging. Mechanisms of Ageing and Development, [online] 131(7–8), pp.487–493. https://doi.org/10.1016/j.mad.2010.04.007.

Zeidan, R.S., Han, S.M., Leeuwenburgh, C. and Xiao, R., 2021. Iron homeostasis and organismal aging. Ageing Research Reviews, [online] 72, p.101510. https://doi.org/10.1016/j.arr.2021.101510

[discoverybody]

Does Hyperbaric Oxygen Therapy (HBOT) Reverse Aging

Hyperbaric Oxygen Therapy (HBOT) is a medical treatment that involves patients breathing pure oxygen in a pressurized chamber. It is widely used to treat decompression sickness, carbon monoxide poisoning, and wounds that do not heal properly. Recently, there has been a growing interest in HBOT's ability to reverse the aging process.

HBOT enhances oxygen flow to the body's tissues, which promotes healing and reduces inflammation. It also increases the creation of new blood vessels, which can aid with circulation. While HBOT is already utilized to treat a variety of medical conditions, its potential anti-aging effects are still being investigated.

According to some research, HBOT may have anti-aging effects by lengthening telomeres and slowing cellular senescence. Telomeres are protective caps on chromosomes that shorten with age, and cellular senescence is linked to aging. HBOT may also increase mitochondrial activity, which decreases with aging and contributes to age-related diseases.

Furthermore, HBOT may reduce oxidative stress and inflammation, improving cellular health and possibly reducing the aging process. However, further research is required to properly understand HBOT's processes and potential anti-aging applications.

It is crucial to highlight that HBOT is not a cure-all for aging and should not be used as a substitute for a healthy lifestyle. While there is some scientific evidence that HBOT has potential anti-aging advantages, additional research is needed to establish its effectiveness.

[perfecthealthsciences]

Exploring Lifespan.io and the Exciting World of Anti-Aging

In the quest for eternal youth, humanity has long been captivated by the idea of extending lifespan and delaying the aging process. From ancient myths of magical fountains to modern scientific breakthroughs, the pursuit of longevity has been a timeless endeavor. In recent years, platforms like Lifespan.io have emerged as beacons of hope, uniting researchers, enthusiasts, and curious minds in the fight against aging. Join me as we embark on a fascinating journey into the realm of anti-aging science, exploring Lifespan.io and the cutting-edge discoveries shaping the future of longevity.

Unraveling the Mysteries of Aging:

Before diving into the intricacies of anti-aging research, let's first unravel the mysteries of aging itself. Aging is a complex phenomenon influenced by a myriad of factors, including genetics, lifestyle, and environmental exposures. At its core, aging is characterized by a gradual decline in cellular function and tissue integrity, leading to an increased susceptibility to age-related diseases and ultimately death.

However, aging is not simply an inevitable fate dictated by our genes. Rather, it is a dynamic process shaped by a delicate interplay of biological mechanisms, many of which are now being unraveled by scientists around the globe. From telomere shortening to mitochondrial dysfunction, researchers are uncovering the underlying drivers of aging and exploring innovative strategies to counteract its effects.

Enter Lifespan.io: A Hub for Anti-Aging Innovation

At the forefront of the anti-aging revolution stands Lifespan.io – a pioneering platform dedicated to advancing longevity research through crowdfunding and community engagement. Founded in 2013 by a passionate team of advocates, Lifespan.io serves as a catalyst for groundbreaking research projects aimed at extending healthy lifespan and combating age-related diseases.

One of the key pillars of Lifespan.io's mission is to democratize science by empowering individuals to contribute directly to cutting-edge research initiatives. Through crowdfunding campaigns, supporters can rally behind promising anti-aging projects, providing crucial funding to accelerate progress in the field. From rejuvenating senescent cells to harnessing the power of artificial intelligence in drug discovery, Lifespan.io projects span a diverse array of disciplines, each with the potential to revolutionize our understanding of aging.

But Lifespan.io is more than just a fundraising platform – it's a vibrant community of scientists, advocates, and enthusiasts united by a shared vision of a world without age-related diseases. Through its online forums, webinars, and educational resources, Lifespan.io fosters collaboration and knowledge-sharing, empowering individuals from all walks of life to join the fight against aging.

The Science of Aging Reimagined:

Now, let's delve into the exciting realm of anti-aging science and explore some of the groundbreaking discoveries shaping the future of longevity. From rejuvenating therapies to age-defying interventions, researchers are harnessing the power of innovation to rewrite the narrative of aging.

Cellular Senescence and Rejuvenation:

At the cellular level, aging is closely linked to the accumulation of senescent cells – damaged cells that have ceased to divide and contribute to tissue dysfunction. Targeting these "zombie cells" has emerged as a promising strategy for rejuvenating aging tissues and extending lifespan. Through innovative approaches such as senolytic therapies and genetic engineering, scientists are paving the way for a new era of regenerative medicine, where age-related decline can be reversed at its source.

Telomeres and the Aging Clock:

Telomeres – the protective caps at the ends of chromosomes – play a crucial role in cellular aging and longevity. As telomeres shorten with each cell division, they serve as a molecular clock that regulates the lifespan of cells. By understanding the mechanisms underlying telomere maintenance and degradation, researchers are uncovering novel targets for anti-aging interventions. From telomerase activation to telomere lengthening strategies, the quest to unlock the secrets of telomeres holds immense promise for extending healthy lifespan.

Mitochondria and Metabolic Health:

Mitochondria – the powerhouse of the cell – play a central role in energy production and cellular metabolism. As we age, mitochondrial function declines, leading to an accumulation of oxidative damage and metabolic dysfunction. Restoring mitochondrial health has thus emerged as a key focus of anti-aging research, with potential implications for a wide range of age-related conditions, from neurodegenerative diseases to cardiovascular disorders. From mitochondrial-targeted antioxidants to mitochondrial replacement therapies, scientists are exploring innovative strategies to rejuvenate aging mitochondria and promote healthy aging.

Epigenetics and Aging Clocks:

Beyond the realm of genetics lies the fascinating world of epigenetics – the study of changes in gene expression that occur without alterations to the underlying DNA sequence. Epigenetic modifications play a crucial role in regulating aging-related processes, serving as molecular switches that control gene activity. By deciphering the epigenetic signatures of aging, researchers have developed powerful tools for predicting biological age and assessing the efficacy of anti-aging interventions. From epigenetic clocks to epigenome editing technologies, the field of epigenetics is revolutionizing our understanding of aging and opening new avenues for intervention.

The Road Ahead: Challenges and Opportunities

As we journey deeper into the realm of anti-aging science, it's important to acknowledge the challenges that lie ahead and the opportunities that await us on the road to longevity. From regulatory hurdles to ethical considerations, the path to translating anti-aging discoveries into clinical applications is fraught with obstacles. However, with perseverance, collaboration, and a shared commitment to advancing human health, we have the potential to overcome these challenges and unlock the full promise of longevity research.

In closing, let us embrace the spirit of exploration and discovery as we continue to push the boundaries of what is possible in the quest for eternal youth. Through platforms like Lifespan.io and the tireless efforts of scientists, advocates, and enthusiasts around the globe, we stand poised to usher in a new era of health and vitality for generations to come. Together, let us seize the opportunity to rewrite the story of aging and unlock the fountain of youth for all humanity.

Join us on this extraordinary journey – the future of longevity awaits.

[healthyhabitjournal]

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[drrobertkast]

The Role of Telomeres in Reversing the Aging Process

Dr. Robert Kast practices in Boca Raton, Florida. An experienced and board-certified obstetrician and gynecologist, Dr. Robert Kast maintains an interest in the role of telomeres in reversing the aging process.

Aging is an inescapable part of life. Scientists are exploring whether increasing telomere length can help reduce the aging process. During the DNA replication process, which sustains an organism, the chromosomes might become too short and eventually die.

Each strand of DNA has two ends. The strands can become tangled, frayed, or shortened without protection. A depletion of genetic material contributes to aging. Telomeres protect DNA by forming a cap, similar in principle to the plastic tip found on the end of shoelaces. The protection allows for proper replication during cell division.

To maintain and increase telomere length, scientists use an enzyme known as telomerase. The enzyme telomerase adds to the sequencing process. Telomerase carries its RNA ribonucleoprotein (template), which enables it to elongate telomeres.

Enhancing telomerase ensures that telomeres don’t get too short or die. Scientists suggest that reactivating the telomerase enzyme, which boosts cell replication, might reverse premature aging.

[stanford--pines]

Ah, I have a page in the journal about rising the dead did you use a similar spell? If you'd take a suggestion, what about just reversing the effects of aging? You can heal people can't you? it might be a tricky thing to do but you would, hypothetically, just need to heal the individual cells before they begin to completely deteriorate. For example, there's an interesting theory that the telomeres tend to shorten with each replication and will stop dividing eventually, so reversing them back to their initial length after some time would fix such an issue. Though, that sounds like quite a hassle and would be more like resetting a dying body rather than true immortality.

Oh no.. I can't believe we've been such complacent fools! Well, if the aliens think they can get away with such a thing they are sorely mistaken. Once I get the materials and funding to do so, I'll pay them a visit.

Before they became a couple

My input on the earlier stage of their relationship based on @honeqq 's married billford au!!