#restoresvision

[wellextol]

Ocuprime for Perfect Eyesight: Natural Vision Loss Remedy-Cure Vision Problem & Repair Eyesight

[gravityresearch]

Reversal of ageing-and injury-induced vision loss by Tet-dependent epigenetic reprogramming

Ageing is a degenerative process leading totissuedysfunctionand death. A proposedcauseof ageingis the accumulation of epigenetic noise,which disruptsyouthful gene expression patternsthat are required forcells to function optimallyand recover from damage1-3.Changes toDNA methylationpatterns over timeform the basis of an 'ageingclock'4,5,but whether old individualsretaininformation to reset the clockand, if so,whether thiswouldimprovetissue function isnot known. Of all the tissues in the body, the central nervous system (CNS) is one of the first to lose regenerative capacity6,7.Using the eye as a model tissue, we showthatexpressionof Oct4, Sox2, and Klf4 genes (OSK)in mice resetsyouthful gene expression patternsand the DNA methylation age ofretinal ganglioncells,promotesaxon regenerationafter optic nerve crush injury,and restoresvision in amousemodel of glaucomaand in normalold mice. This process, which we call recovery of information via epigenetic reprogrammingor REVIVER,requiresthe DNA demethylases Tet1 and Tet2, indicating that DNA methylation patterns don't just indicateage, theyparticipatein ageing. Thus, old tissuesretaina faithful record of youthful epigeneticinformation that can be accessed forfunctional age reversal.

https://www.biorxiv.org/content/biorxiv/early/2019/07/31/710210.full.pdf