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#mk. nano 22
howlingbreeze · 2 years
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just made my lil nano tracking in google sheets, bc the site is always so dodgy. can’t wait to start. just need to keep solidifying outlines until day 1!
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industryupdatenews · 4 years
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The ongoing COVID-19 Pandemic Expected to Burgeon the Scope of Nano Crystalline Soft Magnetic Material – Fact.MR Report
Fact.MR has prepared a research study on Global NANO CRYSTALLINE SOFT MAGNETIC MATERIAL Market and has made use of a multi-disciplinary approach to come up with a detailed and clear picture of the evolution of the Global NANO CRYSTALLINE SOFT MAGNETIC MATERIAL Market for the forecast period of 2020 to 2030. This study offers an in-depth analysis of the key prospects of growth, main growth avenues in the estimation year of 2020, and existing growth dynamics over the assessment period, 20XX to 20YY. At the same time, the report also prepares the stakeholders for effectively dealing with the threats and challenges in the global NANO CRYSTALLINE SOFT MAGNETIC MATERIAL DEMAND market.
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The prevailing challenges,     restraints, opportunities, and drivers of the market
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Influence of Covid-19 in the     market and how the pandemic is going to shape the contours of the market     in the forthcoming years
Technologies and business models     with disruptive potential 
Role of regulatory bodies in     boosting new growth opportunities of the market across different parts of     the world
How new market developments are     likely to  influence the market at large in the near future 
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·         North America (U.S., Canada)
·         Latin America (Brazil, Mexico, Argentina, Rest of Latin America)
·         Europe (Germany, Italy, France, U.K., Spain, Benelux, Russia, Rest of Europe)
·         East Asia (China, Japan, South Korea)
·         Japan
·         APEJ (China, India, Indonesia, Thailand, Singapore, Australia & New Zealand, Rest of Asia Pacific)
·         South Asia & Oceania (India, Thailand, Indonesia, Malaysia, Australia & New Zealand, Rest of South Asia & Oceania)
·         Middle East & Africa (GCC Countries, Turkey, Northern Africa, South Africa, Rest of Middle East & Africa)
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·         MH&W International Corp
·         Bomatec
·         MK Magnetics
·         Hitachi Metals Ltd.
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·         Consumer Electronics
·         Renewable Energy
·         Electric Power
·         Aerospace
·         Medical
·         Transportation
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·         14~18μm Thickness
·         18~22μm Thickness
·         22~26μm Thickness
·         Others
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How Covid-19 could cause     disruptions in the supply chain of the chemical and materials industry?
What factors of the market are     likely to hold lucrativeness for the market players?
What could restrain the expansion     of the market in the chemicals and materials industry?
Which of the product or service     segment could prove to be most lucrative for the market?
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How technological advancements are     likely to impact the market in the near future?
What macro and micro factors are     at play in each of the regions of the market?
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What are COVID-19 implications on     the global NANO CRYSTALLINE SOFT MAGNETIC MATERIAL market and learn how     businesses can respond, manage, and mitigate the risks?
About Fact.MR
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sciencespies · 5 years
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2019: A Year of Many New Beginnings for Indian Space Sector
https://sciencespies.com/news/2019-a-year-of-many-new-beginnings-for-indian-space-sector/
2019: A Year of Many New Beginnings for Indian Space Sector
The year 2019 was a year of several new beginnings for India’s space sector that is now on Mission 2.0 mode.
The year also saw the Indian Space Research Organisation (ISRO) scoring a couple of half centuries, like putting into orbit 50 foreign satellites and also sending up its 50th Polar Satellite Launch Vehicle (PSLV).
However, the one jarring note in the success symphony was the crash landing of India’s moonlander Vikram on the lunar surface.
The year also saw ISRO and Department of Space (DoS) taking firm steps towards setting up of second rocket launch pad in Tamil Nadu; flying Indian rockets with indigenously developed navigation processor chip; formation of NewSpace India Limited to involve private sector in making rockets and also taking over the commercial activities of Antrix Corporation.
The NewSpace India had issued an Expression of Interest (EoI) for first manufacturing five Polar Satellite Launch Vehicle (PSLV) rockets from private sector.
The year 2019 witnessed the ISRO touching the mark of 319-foreign satellite launches; deciding to go for another moon landing mission called Chandrayaan-3; setting up Human Space Flight Centre; starting the young scientist programme; signing agreement with Indian Air Force (IAF) to select and train Indian astronauts for the country’s manned mission.
The space agency also laid the foundation stone for a centre to monitor and protect high value space assets from space debris.
The ISRO began the year with the launch of defence imaging satellite “Microsat R” for the Defence Research and Development Organisation (DRDO).
Later in March, the DRDO shot down Microsat R to demonstrate its anti-satellite missile prowess.
During 2019, ISRO also launched several earth observation satellites like the Emisat, an electronic intelligence satellite for DRDO, Cartosat-3, radar imaging satellites RISAT-2B, and RISAT-2BR1.
As India’s eyes in the skies, these satellites will serve the needs of strategic sectors.
In the communication satellite space, the ISRO launched the country’s 40th communication satellite GSAT-31 by an Ariane 5 rocket belonging to Arianespace.
On the rocket side, while ISRO flew its 50th PSLV and also launched two new variants of the rocket- PSLV-DL (with two strap-on motors) and PSLV-QL (with four strap-on motors).
The space agency flew a PSLV rocket in three orbits during the same mission and also used the fourth stage as an orbital platform carrying three experimental payloads.
The space agency also gave finishing touches to its new rocket-Small Satellite Launch Vehicle (SSLV) with a capacity to carry 500 kg. The rocket is expected to be flown next year.
In June, ISRO Chairman K. Sivan surprised the nation by announcing that the country would build its own 20-tonne space station in the next 5ive to seven years’ time after the first manned mission.
Between July-September the focus was on the country’s second moon mission-Chandrayaan-2.
On July 22, the Rs. 375 crore, heavy lift Geosynchronous Satellite Launch Vehicle (GSLV-Mk III) rocket slung the Rs. 603 crore, 3.8-tonne Chandrayaan-2 spacecraft in its intended earth parking orbit.
The Chandrayaan-2 spacecraft comprised of three segments — the Orbiter (weighing 2,379 kg, eight payloads), the lander ‘Vikram’ (1,471 kg, four payloads) and rover ‘Pragyan’ (27 kg, two payloads).
Everything went off well as regards the moon mission was concerned till the fateful early morning of September 7 when Vikram that was racing to set its foot on the moon crashed into lunar surface at a very great speed and broke into pieces.
While ISRO had said it had found Vikram’s debris on Sep 8 itself, it did not release any image in support.
The Indian space agency had also sought the assistance of US space agency NASA in locating Vikram on the moon’s surface.
It was only recently a Chennai based 33-year old mechanical engineer Shanmuga Subramanian originally from Madurai and now a Technical Architect at Lennox India Technology Centre who spotted the Vikram debris on the pictures released by US space agency NASA.
The US space agency NASA has credited him for discovering the debris of Vikram.
The one consolation is the functioning of the Chandrayaan Orbiter.
Meanwhile, the year also saw ISRO putting into orbit 50 foreign satellites for a fee and also flying the 50th PSLV rocket.
According to Sivan, PSLV has lifted a total of 52.7 tonne till date and out of that 17 per cent consists of customer satellites.
Sivan said the space agency has several more missions lined up in 2020 including the inaugural flight of the new rocket SSLV.
Chandrayaan-2’s Scientific Objectives Fully Accomplished, Minister Claims
Cartosat-3: ISRO Successfully Launches Earth Imaging Satellite Along With 13 US Nano Satellites
ISRO Successfully Inserts RISAT-2BR1 Satellite Into Orbit, Touches 319 Foreign Satellite Launch Mark
Chandrayaan-2 Vikram Lander: Space Failure Part of Big Game, NASA-JPL CTO Says
#News
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tumimmtxpapers · 7 years
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Liposome-induced immunosuppression and tumor growth is mediated by macrophages and mitigated by liposome-encapsulated alendronate.
Related Articles Liposome-induced immunosuppression and tumor growth is mediated by macrophages and mitigated by liposome-encapsulated alendronate. J Control Release. 2017 Dec 22;: Authors: Rajan R, Sabnani MK, Mavinkurve V, Shmeeda H, Mansouri H, Bonkoungou S, Le AD, Wood LM, Gabizon AA, La-Beck NM Abstract Liposomal nanoparticles are the most commonly used drug nano-delivery platforms. However, recent reports show that certain pegylated liposomal nanoparticles (PLNs) and polymeric nanoparticles have the potential to enhance tumor growth and inhibit antitumor immunity in murine cancer models. We sought herein to identify the mechanisms and determine whether PLN-associated immunosuppression and tumor growth can be reversed using alendronate, an immune modulatory drug. By conducting in vivo and ex vivo experiments with the immunocompetent TC-1 murine tumor model, we found that macrophages were the primary cells that internalized PLN in the tumor microenvironment and that PLN-induced tumor growth was dependent on macrophages. Treatment with PLN increased immunosuppression as evidenced by increased expression of arginase-1 in CD11b+Gr1+ cells, diminished M1 functionality in macrophages, and globally suppressed T-cell cytokine production. Encapsulating alendronate in PLN reversed these effects on myeloid cells and shifted the profile of multi-cytokine producing T-cells towards an IFNγ+ perforin+ response, suggesting increased cytotoxic functionality. Importantly, we also found that PLN-encapsulated alendronate (PLN-alen), but not free alendronate, abrogated PLN-induced tumor growth and increased progression-free survival. In summary, we have identified a novel mechanism of PLN-induced tumor growth through macrophage polarization and immunosuppression that can be targeted and inactivated to improve the anticancer efficacy of PLN-delivered drugs. Importantly, we also determined that PLN-alen not only reversed protumoral effects of the PLN carrier, but also had moderate antitumor activity. Our findings strongly support the inclusion of immune-responsive tumor models and in-depth immune functional studies in the preclinical drug development paradigm for cancer nanomedicines, and the further development of chemo-immunotherapy strategies to co-deliver alendronate and chemotherapy for the treatment of cancer. PMID: 29277680 [PubMed - as supplied by publisher] http://dlvr.it/Q7n2Qv
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Are "Suitcase Nukes" Floating Around For Purchase by Terrorists?
New Post has been published on http://rolexsubmariner.shop/are-suitcase-nukes-floating-around-for-purchase-by-terrorists-3/
Are "Suitcase Nukes" Floating Around For Purchase by Terrorists?
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George Tenet, the man who served as director of the Central Intelligence Agency on the day of the 9/11 terrorist attack — indeed, a man who served in that stressful job for almost eight years under two presidents — tells the riveting story in his memoirs of how Saudi intelligence captured a handful of senior Al Qaeda operatives in 2003, a group that included the notorious Shaykh Nasir bin Hamin al-Fahd. It was a real coup.
What made Al-Fahd fall onto the radar of every intelligence service in Europe and America was a document he authored with the terrifying title “A Treatise on the Legal Status of Using Weapons of Mass Destruction Against Infidels.” The weapons he’s referring to are atomic bombs. Where on earth would Al Qaeda terrorists get atomic bombs?
Al-Fahd had clearly made a credible exhortation, from the top level of Al Qaeda senior management, to use nuclear weapons against Western targets. And now he was in a Saudi dungeon.
Under merciless interrogation by the Saudi Mukhabarat (the secret police), using methods that would have been frowned upon even at Guantanamo, Al-Fahd confessed that Al Qaeda had been bargaining with black market arms merchants in Moscow for “portable” nuclear weapons. Though under extreme duress, Al-Fahd would not (more likely, could not) reveal useful details.
We tend to think of nuclear weapons as very big objects, devices like “Fat Boy,” the bomb that partially Nagasaki — big, heavy objects that need submarines or missiles or Air Force flying fortresses to move around. But there has long been a sub-category of much smaller nuclear weapons, including several designs made by the United States. These are often referred to by media as “suitcase nukes” or “vest-pocket nukes.”
The two most famous of these produced by USA were the “Davy Crockett” a rifle-launched nuclear device that was fired much like a mortar at an enemy a few miles away, and the Mk-54 SADM (Special Atomic Demolition Munition) a 60-pound bomb that was small enough to fit in a large trunk or footlocker.
Though these weapons were pipsqueaks compared to the nation-destroying multi-megaton hydrogen bombs developed in the 1950s and 1960s, any atomic bomb, even the smallest, is capable of killing millions of human beings in urban environments.
The least complex device, in theory, would simply be a mass of purified plutonium that was approaching criticality under normal conditions at room temperature. If you accumulate between 20 and 22 pounds of elemental plutonium in a sphere, the internal level of radiation soon reaches sufficient intensity to cause spontaneous fission of the entire mass — in a matter of nano-seconds, the reaction gets out of control and you have a nuclear explosion. Such a bomb would require no detonator, just the accumulation of the plutonium in one place. It would surely also incinerate whoever was unwise enough to put that much plutonium together in one place.
Even a piece of plutonium the size of a half-dollar is warm to the touch, so much internal fission is taking place, releasing energy all the time.
The actual “suitcase” weapons built by the United States could deliver something in the neighborhood of five kilotons of explosive force (compared to 16 kilotons for the bomb that destroyed Hiroshima and 21 kilotons for the bomb dropped on Nagasaki).
A fifteen kiloton device detonated in central Manhattan would vaporize everything within a radius of just over a mile. Anyone within five to 10 miles would likely fall prey to radiation poisoning, burns, or injury from flying debris. Multiple millions would die in such a scenario. Compare that to the 3,000 who died in 9/11.
These small weapons are called “tactical” in the sense that they would be used on the battlefield to change the course of a skirmish rather than define the outcome of a war. Their value was their portability and size. But that was also their main liability. They were likely to explode so close to the people who deployed them that nuclear blowback and fallout could affect the wrong troops.
A 1994 U.S. law (since repealed in the aftermath of 9/11) forbade nuclear weapons with a yield of five kilotons or less, but by 1994 the Pentagon had long ago mothballed such weapons as unpractical and almost useless.
America’s “suitcase” weapons can all be accounted for. But what happened to those made in the former USSR? A number of Soviet-era defectors, including Stanislav Lunev, have described the Russian devices in great specificity. Lunev assured American spy agencies that many of them were lost in the period of perestroika, when Gorbachev and the first President Bush agreed on wide-reaching nuclear arms reductions. In that period, some 30,000 nuclear weapons were supposedly recalled to Moscow.
If only one per cent of them slipped through the net, then 300 such weapons could be floating around on the black market for purchase by terrorists. Not even the most optimistic scenarios suggest that 99 per cent of the weapons were safeguarded, so the true number is certainly much larger than 300 weapons.
Though critics today regularly dismiss talk of “suitcase nukes” as fodder for thriller writers, George Tenet reports in his autobiography that the CIA was unable to get any good leads on the hundreds of missing Soviet-era nuclear bombs that certainly never made it back to Moscow for disassembly.
“Of all al-Qaeda’s efforts to obtain other forms of WMD, the main threat is the nuclear one. I am convinced that this is where Osama bin Laden and his operatives desperately wanted to go. They understand that bombings by cars, trucks, trains and planes will get them some headlines, to be sure. But if they manage to set off a mushroom cloud, they will make history — such an event would place Al Qaeda on par with the superpowers and make good Bin Laden’s threat to destroy our economy and bring death into every American household.”
Tenet went on to say that it was not “beyond the realm of possibility” for any terrorist group, not just Al Qaeda, to obtain a nuclear weapon.
“One mushroom cloud would change history,” he wrote.
Another analyst, Paul Williams, has asserted in “Osama’s Revenge: The Next 9/11” that Al Qaeda has been planning a spectacular nuclear fire show using a half-dozen portable nuclear weapons that would be detonated simultaneously in major American urban centers.
So where are the missing Russian bombs? Retired Russian generals and colonels who were in positions of authority when Gorbachev ordered the recall of nuclear technology have claimed that at least fifty ADMs (atomic demolition devices, the smallest size nuclear bomb) could definitively not be accounted for and had to be presumed to be in the hands of bad actors, probably for sale to the highest bidder. Such allegations are hard to prove, but they are equally hard to disprove.
And what would it take to keep a “suitcase nuke” in operable condition, even thirty or forty years after its manufacture?
The main requirement would be a permanent source of electricity to keep the internal electrical mechanics functioning and the batteries charged. A simple wall outlet in any home or office would do very nicely.
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howlingbreeze · 2 years
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first day of nano over. major productivity, which will save me in the middle of the month when my brain stops working. flipped a coin to know what story to start with, wolves of the hallowed won. i love writing these characters. have a snippet from today's 4,052 words.
Chapter One: Oliver's POV
Moving from the group he let himself wander around the perimeter, watching the people inside, like they were animals for humans to take photos of and brag to their friends about what they’d seen. He remembered once being told---possibly at the Institute---on the Old Earth they had something called zoo’s where humans kept animals for entertainment, he hated that idea as much as this one.
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howlingbreeze · 2 years
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day 11. trying to get words out before work, knowing that im using all my spoons to do this and not saving them for work.
Chapter 7 Avery’s POV
Vines crawled up the solid walls and around the weather-worn corners, there were stained glass windows with images of the stars and planets that had been shattered from animals. The closer they got to the massive building, Avery felt smaller than he ever had, the dome towering over him. He was amazed it had stayed so hidden out here, unable to see it from the complex. The doors were wooden, falling off their rusty hinges, Basil tired to be careful when pushing them but small flacks on rusted metal and dishevelled wood came off in the process.
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howlingbreeze · 2 years
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howlingbreeze · 2 years
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day 9. better day.
Chapter Six: Oliver’s POV
Acting for survival was all he could do now, until he didn’t have to hide it any longer and he couldn’t wait for that day. When he could stand over his mother and watch everything burn down around him, the flames warming his pale skin and darkening his lavender eyes.
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howlingbreeze · 2 years
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day five. well, i didn’t think i would have the energy to write anything today but i wrote 1,300 words which is a little wild. i hit my weekly wordcount too (10,500). i also hit my 10,000 reward goal, which means i get to eat some special chcolate tonight when i finish work. today i was able to work out how to make this Viper chaper bigger and now i’m up to the point where Oliver and Avery are going to meet for the first time *squeels*.
Chapter Five: Viper’s POV
‘May I come in? I had some questions about your work if you are able to spear the time?’ He sounded like confectionary sugar, light and fluffy.
‘I guess so.’ Viper didn’t want to turn him down if he was here on his own volition, it felt a lot more dangerous being alone in a room with a crowned Sovereign than when he was standing outside with a group.
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howlingbreeze · 2 years
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day 4. depression got the better of me today, and the lack of outline for the rest of the story. intrpduced Viper today, love her. tomorrow i probably won’t get nay words in bc im working both my jobs and i’m not going to force myself to write if i need to name inbetween. i’m struggling to find the motivation to know what to write in these scenes i don’t have more detailed outlines for, but i knew that was going to happen. might try to spend some time next week working on some outline stuff.
Chatper Five: Viper’s POV.
She knew that if The Sovereign was here, her actions would’ve caused her public scolding. But her children didn’t care her, the daughter choose not to run into her position but become a Politician and her son who didn’t show much interest in the job he was given as crown Sovereign. They’d never publicly punished anyone in their lives, they had nothing to be guilty for… not yet anyway. Soon enough Oliver de Astor would become one of the most horrific men in the solar system just because of his role.
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howlingbreeze · 2 years
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day 22. the end is in sight, one more week. dropped my goal by 10k becuase i got sick and i can feel my mh getting dodgy again. liking what i wrote today though. decided to remove the chapter markers and just place in pov and page breaks betweent things. chapter structure stresses me out too much and i get lost in what is supposed to happen in a chapter rather than the story.
woth: 23k fmsb: 5k
Avery’s POV                
Slipping through the complex’s empty, dark streets back the way he’d come, Avery realised just how uncomfortable he felt amongst the concrete. The night seeped into every single craves that it could, warning any wonders that they might lose their way if they were not weary of their direction. Avery kept his eyes forward, head bowed so the cotton hood would cover most of his face. Keeping his eyes from sight was a priority, he couldn’t risk being caught now. He was the only one who knew the relic of Atlas was missing.
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howlingbreeze · 2 years
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I'll be dropping my nano goal to 32k. ive just gotten sick and can bearly think, i probs wont recover enough to get my remaining words.
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howlingbreeze · 2 years
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day 18, besties i hit 25k today and i cant believe it. i feel like most of these words are good words too!
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howlingbreeze · 2 years
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day 3, a quieter day. i had irl things to do outside of work so it took up some writing time (1,773). hopfully tomorrow i can reach my next goal, but it’s a big ask. as long as i get in 2,079 words in the next 3 days i will have hit my weekly goal and that’s all i can be happy about honestly. here is todays excerpt.
Chapter Four: Oliver’s POV
‘I will be accompanying you, rather than mother. She’s decided she has more important matters to attend too, than looking at the slaves of Ganymede.’ Rolling their eyes, they took up space on Oliver’s bed creasing the perfect linen. There was something so satisfying about the damage of something so particular, creating a chaos within the threads of the sheets.
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howlingbreeze · 2 years
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over 2,000 words today! wild stuff.
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