#jeffrey grob

[paula-of-christ]

Please pray for our new Archbishop, who will be installed this coming January.

[laus-deo]

Cuando el nuevo arzobispo de Milwaukee ayudó a esclarecer el asesinato ritual de una monja

Jeffrey S. Grob, de 63 años, fue nombrado recientemente arzobispo de Milwaukee (EEUU) por el Papa Francisco. Lo interesante de su figura es que se desempeñó varios años como exorcista oficial de la Archidiócesis de Chicago (EE.UU), y, antes, ayudó a esclarecer el asesinato ritual de una monja por parte de un sacerdote. El libro de David Yonke Sin Shame and Secrets cuenta cómo Grob ayudó a los…

[chicagocatholicman]

Pope Francis has accepted the resignation of Archbishop Jerome E. Listecki, 75, from the pastoral governance of the Archdiocese of Milwaukee, and has appointed Bishop Jeffrey S. Grob, auxiliary bishop of Chicago, as his successor.

[christianpureofficial]

Pope Francis appoints Chicago auxiliary bishop to lead Milwaukee Archdiocese

Pope Francis on Nov. 4, 2024, named Chicago Auxiliary Bishop Jeffrey Grob as archbishop of Milwaukee. / Credit: Archdiocese of Milwaukee Vatican City, Nov 4, 2024 / 14:00 pm (CNA). Pope Francis on Monday accepted the resignation of Milwaukee Archbishop Jerome Listecki and named Chicago Auxiliary Bishop Jeffrey Grob to be his successor. With the Nov. 4 appointment, the 63-year-old Grob will be…

[rainingmusic]

LOOKING GLASS "JIMMY LOVES MARY ANNE'

[psicopathya]

Marco Grob

Jeffrey Leon Bridges

[njawaidofficial]

Marvel Studios Released A 10th Anniversary Class Photo Including Every Single Hero And It Will Make You Emotional

https://styleveryday.com/2018/02/09/marvel-studios-released-a-10th-anniversary-class-photo-including-every-single-hero-and-it-will-make-you-emotional/

Marvel Studios Released A 10th Anniversary Class Photo Including Every Single Hero And It Will Make You Emotional

Avengers assemble…for picture time!

It’s hard to believe that it’s been exactly 10 years since the crazy train that is the Marvel Cinematic Universe left the station.

Marvel Studios

With the first Iron Man film leading the way back in May of 2008, the franchise took off at a break-neck speed, and hasn’t stopped since.

Marvel Studios

And today Marvel Studios released a behind-the-scenes video of a celebration which took place last October in honor of this achievement, where every single actor in their films gathered for a class photo.

Marvel Studios / Via youtube.com

It’s difficult not to get a little emotional watching the heroes we’ve grown up loving geek TF out over each other.

Marvel Studios

And seeing them all in one room is almost too trippy too handle.

Marvel Studios

Plus, the class photo itself is already an ICONIC work of art:

Marco Grob for Marvel Studios

Seriously.

First Row: Sean Gunn, Hannah John-Kamen, Director Scott Derrickson, Executive Producer Trinh Tran, Jeremy Renner, and Paul Rudd.

Second Row: Director Jon Watts, Casting Director Sarah Finn, Tessa Thompson, VP Physical Production David Grant, Don Cheadle, and Tom Holland.

Third Row: Director Peyton Reed.

Marco Grob for Marvel Studios

Just.

First Row: EVP Physical Production Victoria Alonso, Zoe Saldana, Angela Bassett, and Jon Favreau.

Second Row: Director James Gunn, Dave Bautista, Michael Peña, Anthony Mackie, and Evangeline Lilly.

Third Row: Director Peyton Reed, Laurence Fishburne, Linda Cardellini, Executive Producer Jonathan Schwartz, Sebastian Stan, and Ty Simpkins.

Fourth Row: Screenwriter Christopher Markus, Screenwriter Stephen McFeely, and Michael Rooker.

Marco Grob for Marvel Studios

Look.

First Row: Chris Hemsworth, Gwyneth Paltrow, Chris Evans, Robert Downey Jr., Stan Lee, and President of Marvel Studios Kevin Feige.

Second Row: Director Joe Russo, Director Anthony Russo, Chris Pratt, Chadwick Boseman, and Benedict Cumberbatch.

Third Row: Mark Ruffalo, Brie Larson, Michael Douglas, Executive Producer Stephen Broussard, and Director Ryan Coogler.

Fourth Row: Vin Diesel, Cobie Smulders, Samuel L. Jackson, Taika Waititi, and Jeff Goldblum.

Marco Grob for Marvel Studios

At.

First Row: Scarlett Johansson, Co-President of Marvel Studios Louis D’Esposito, Kurt Russell, Danai Gurira, and William Hurt.

Second Row: Elizabeth Olsen, Director Joss Whedon, Paul Bettany, VP, Physical Production Mitchell Bell, Frank Grillo, Director Anna Boden, and Director Ryan Fleck.

Third Row: Michelle Pfeiffer, Executive Producer Jeremy Latcham, Hayley Atwell, Pom Klementieff, Executive Producer Nate Moore, and Benedict Wong.

Fourth Row: Executive Producer Erik Carroll, Head of Visual Development Ryan Meinerding, and Executive Producer/Screenwriter Craig Kyle.

Marco Grob for Marvel Studios

Them.

First Row: Director Alan Taylor, Karen Gillan, Executive Producer Brad Winderbaum, Emily VanCamp, and Director Louis Letterier.

Second Row: Letitia Wright and Editor Jeffrey Ford.

Marco Grob for Marvel Studios

So, here’s to the next 10 years of Marvel superhero films and, in the meantime, get pumped for Black Panther and Avengers: Infinity War this year!

Marvel Studios

[cancersfakianakis1]

Eighth American Joint Committee on Cancer (AJCC) melanoma classification: Let us reconsider stage III

Publication date: Available online 7 December 2017 Source:European Journal of Cancer Author(s): Jean Jacques Grob, Dirk Schadendorf, Paul Lorigan, Paolo Ascierto, James Larkin, Paul Nathan, Caroline Robert, Axel Hauschild, Jeffrey Weber, Adil Daud, Omid Hamid, Reinhard Dummer, Johan Hansson, Christoph Hoeller, Jacob Schachter, Alexander C.J. Van Akkooi, Claus Garbe http://ift.tt/2AF2taW

[vanitynumbers]

Bitcoin to start futures trading, stoking Wild West worries

New Post has been published on https://mrtollfree.com/business/bitcoin-to-start-futures-trading-stoking-wild-west-worries/

Bitcoin to start futures trading, stoking Wild West worries

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NEW YORK (Reuters) – Bitcoin fans are salivating over the potential of long-awaited legitimacy for the cyptocurrency when futures trading launches this weekend, but experts worry the risks associated with bitcoin’s Wild West-like nature could overshadow the debut.

A bitcoin (virtual currency) coin placed on Dollar banknotes, next to computer keyboard, is seen in this illustration picture, November 6, 2017. REUTERS/Dado Ruvic/Illustration

The first bitcoin future trades kick off Sunday at 6 p.m. EST (2300 GMT) on Cboe Global Markets Inc’s (CBOE.O) Cboe Futures Exchange, followed a week later by CME Group Inc’s (CME.O) CME.

Nasdaq Inc (NDAQ.O) plans to get into the mix next year, Reuters reported.

While Cboe, CME and Nasdaq offer strictly policed trading environments, the underlying bitcoin market is riddled with crypto-exchanges lacking even basic oversight.

That has stoked fears of market manipulation, inaccurate pricing, and systemic risk to clearing houses.

“I‘m kind of taken aback by what’s happened in the last three months,” said Richard Johnson, an analyst at Greenwich Associates who owns digital currencies and considers himself a bitcoin bull. “I‘m concerned things are moving a bit too quickly.”

Bitcoin’s more than 10-fold upsurge this year has led to warnings of a bubble by the likes of JPMorgan Chase & Co (JPM.N) Chief Executive Officer Jamie Dimon, who called it “a fraud” that will eventually blow up. Others, like Wall Street adviser Tom Lee, expect bitcoin to top $100,000.

On Wednesday, its hypervolatility was on full display as it broke through $13,000 for the first time on the Luxembourg-based Bitstamp exchange BTC=BTSP, jumping more than 11 percent on the day.. Since August 2011, bitcoin has averaged a daily price change of nearly 3 percent, up or down, compared with a daily average change in the U.S. dollar-euro cross rate EUR= of less than 0.5 percent since the euro’s debut in 1999.

“Maybe it’s just the most unique market that is going to continue to go up forever and ever and so everybody on the long side is going to make money and it’s a great thing, but I’ve been around long enough to know that’s not going to work out so well,” said John Lothian, CEO of advisory firm John J Lothian and Company.

As a virtual currency, bitcoin can be used to move money around the world without the need for a central authority, such as a bank or government, which is a double-edged sword, said Steve Grob, director of group strategy at Fidessa.

“There is no backstop. If suddenly tomorrow everyone decided bitcoin was worthless, it would be worthless, and I’m not sure whether people have really thought that one through,” he said.

Traditional banks remain skeptical of dealing with bitcoin exchanges. Earlier this year, Wells Fargo & Co (WFC.N) stopped processing wire transfers for an exchange called Bitfinex, leaving customers unable to transfer U.S. dollars out of their accounts, except through special arrangement with the exchange’s lawyer.

Still, new entrants, from retail investors to high-frequency traders, have piled into bitcoin. U.S.-based crypto-exchange Coinbase said it added 100,000 accounts in the three days around the U.S. Thanksgiving holiday, for 13.1 million overall.

If the futures market were to exceed the size of the spot market, with current daily trading volume of around $6 billion per day, the underlying price could be more susceptible to manipulation, said Kevin Zhou, co-founder of crypto currency fund Galois Capital.

“You’ve seen these problems before in bitcoin futures, where right before the settlement, the price pegs it high or low and then bounces back right after,” he said.

RISK OF AN ‘AVALANCHE’

As volumes increase, there are also questions about the robustness of the technology at bitcoin exchanges, Lothian said.

“Particularly when you’re talking about a high-frequency approach to this where people are trying to arb multiple exchanges.”

Last month, the Gemini bitcoin exchange, which will set the price for Cboe’s futures contract, and GDAX and Kraken, two of the four exchanges in CME’s bitcoin index, had systems issues.

“Every single bitcoin exchange receives and is receiving complaints by users due to the unbelievably surging bitcoin price and the result that has on capacity,” Christina Yee, a Kraken representative, recently told Reuters in an email.

Kraken is planning to launch a new trade engine “soon” which should increase the exchange’s capacity, Yee said.

The volatile nature of bitcoin could also present a risk to clearing houses, said Thomas Peterffy, CEO of Interactive Brokers Group Inc (IBKR.O).

Clearing houses act as a middlemen between the parties to futures transactions. If there were a wild price swing in bitcoin and a smaller brokerage failed to meet its margin call, the clearing house would have to take over the position, further moving the price of bitcoin, which could cause other brokers to fail, Peterffy said.

“If that happens at a time when bitcoin spikes up for whatever crazy reason, there could be an avalanche,” he said.

Questions like these have kept some futures market operators on the sidelines, for now. Intercontinental Exchange Inc (ICE.N), owner of the New York Stock Exchange and ICE Futures U.S., opted not to join CME and Cboe in the race to be first with a bitcoin future.

“We didn’t think it was obvious to rush out a product and be first and settle against an index on a lot of exchanges that are not particularly transparent,” ICE Chief Executive Jeffrey Sprecher said this week at a Goldman Sachs conference.

Reporting by John McCrank and Anna Irrera; Editing by Dan Burns and Lisa Shumaker

Our Standards:The Thomson Reuters Trust Principles.

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[cancersfakianakis1]

Three-year pooled analysis of factors associated with clinical outcomes across dabrafenib and trametinib combination therapy phase 3 randomised trials

Publication date: September 2017 Source:European Journal of Cancer, Volume 82 Author(s): Dirk Schadendorf, Georgina V. Long, Daniil Stroiakovski, Boguslawa Karaszewska, Axel Hauschild, Evgeny Levchenko, Vanna Chiarion-Sileni, Jacob Schachter, Claus Garbe, Caroline Dutriaux, Helen Gogas, Mario Mandalà, John B.A.G. Haanen, Céleste Lebbé, Andrzej Mackiewicz, Piotr Rutkowski, Jean-Jacques Grob, Paul Nathan, Antoni Ribas, Michael A. Davies, Ying Zhang, Mathilde Kaper, Bijoyesh Mookerjee, Jeffrey J. Legos, Keith T. Flaherty, Caroline Robert AimUnderstanding predictors of long-term benefit with currently available melanoma therapies is the key for optimising individualised treatments. A prior pooled analysis of dabrafenib plus trametinib (D + T)–randomised trials (median follow-up, 20.0 months) identified baseline lactate dehydrogenase (LDH) and number of organ sites with metastasis as predictive factors for progression-free (PFS) and overall (OS) survival. However, longer-term follow-up analyses are needed to confirm which patients treated with D + T can achieve maximum benefit.MethodsThree-year landmark data were retrospectively pooled for D + T patients in phase 3 trials (COMBI-d [NCT01584648]; COMBI-v [NCT01597908]). Univariate and multivariate analyses assessed prognostic values of predefined baseline factors; regression tree analysis determined hierarchy and interactions between variables.ResultsLong-term pooled outcomes were consistent with individual trial results (N = 563; 3-year PFS, 23%; 3-year OS, 44%). Baseline LDH level and number of organ sites remained strongly associated with and/or predictive of PFS and OS. In addition, baseline sum of lesion diameters (SLD) was identified as a predictor for progression. In the most favourable prognostic group (normal LDH, SLD <66 mm, <3 organ sites; n = 183/563 [33%]), 3-year PFS was 42%. Baseline number of organ sites was also predictive of outcomes in patients with PFS ≥ 6 months.ConclusionUsing the largest phase 3 data set available for BRAF/MEK inhibitor combination therapy in melanoma, these results demonstrate that durable responses lasting ≥3 years are possible in subsets of patients with BRAF-mutant melanoma receiving D + T. Although the best predictive model evolved with longer follow-up, factors predicting clinical outcomes with the combination remained consistent with previous analyses. http://ift.tt/2rGXvVX