#injectable 1-Testosterone cypionate

[fatmasc]

btw after 1 year on T it's become alarmingly aware to me that lots of ppl don't know u can have an allergic reaction to HRT injections. Testosterone cypionate is formulated with cottonseed oil and its not exactly uncommon to be allergic to that! there are other formulations (I personally use testosterone enanthate) and if none of them work for u there are other way to take testosterone. if u are having big itchy welts at ur injection sites PLS talk to ur doctor ab switching ur formulation

[play-now-my-lord]

i liked your post about how trans women's joy in womanhood is gender-affirming for you as a cis woman. real quick can you look up for me if any of your local planned parenthoods prescribe testosterone. testosterone cypionate or androgel, doesn't really matter. it's prescribed on an informed consent basis usually. 100mg per 7 days of cypionate injected into the belly of the thigh tapering up to 200mg as desired or 1-2 pumps of androgel per day applied to the torso ideally the stomach btw

[cometbeast]

diy masculinising hrt guide (uk)

1. set up online/mobile banking if you haven't already (this step may not be necessary depending on payment method)

2. go to suppdirect.com

3. order a 10ml vial testosterone cypionate or testosterone enanthate, with shipping this will be about 40 quid

4. choose to pay by bank transfer at checkout

5. wait for an email with payment details

6. follow the instructions in the email (they used to send bank details but now send a link to a payment portal)

8. you can find videos showing how to do intramuscular injections on youtube

7. order 1ml syringes and needles from a website like medisave.co.uk

re: needle size: 1 inch needles are suitable for intramuscular injection. you need a smaller gauge for injecting (23-27) and a larger gauge for drawing up the medication (21-18). supposedly 18g needles can damage the rubber seal of the vial over time but i have never had this problem 🤷‍♂️ over time you'll work out your preferences

9. start with 25mg per week if you want slower changes, 50mg for faster changes, eventually moving up to 100. if the vial is 200mg/ml 25mg will be 1/8 of a ml and 50mg will be 1/4 of a ml

[defilerwyrm]

hi! I've come asking questions about transition (as a trans boy) more specifically, you mentioned that you've used both testosterone cream and injections.

Do you mean the cream/gel kind of HRT that is used once daily? If so, I was wondering whether you noticed any difference in the uptake or changes in the rate of your transition compared to injections. Did changes happen at the same rate as injections or a bit slower, since I've heard there can be problems of the skin not absorbing T as well as injections. Do you have any personal experiences of this?

Also if it's not too personal, which kind of HRT are you on now (injection/cream) and why did you choose to stick with it, if that was your own choice? (ik there can be insurance/supply issues that might affect it)

Howdy! So: this was a ride.

My first provider (not naming names, but she’s a doctor who works in downtown Austin) gave me two choices: find time to take a 1- to 1.5-hour round trip downtown, pay the $20 copay, and have a nurse give me an injection every single week; or use a daily cream from a compounding pharmacy that delivered. For reasons of time and money, I went with the cream.

I was on it for a year; I don’t remember my dosage exactly, but it was something like two clicks of a finicky dispenser. I was on it for a solid year and the only change that occurred was I got a couple more annoying, embarrassing PCOS hairs on my throat. Absolutely nothing else. Meanwhile, every 3 months or so I’d express my frustration with this to my doctor, and she’d just tell me to be patient. Or, you know, come in and pay the copay every week instead.

Now any number of things could have been going on here. She could have had me on a comically-low dose (I really have zero memory of what it was). My biochemistry could have overpowered or resisted it. The compounding pharmacy could have been bullshit. Who knows.

By comparison, right around three months on testosterone cypionate injections, my voice broke and I started sprouting facial and body hair in spades.

Between what my second HR provider (the one who got me onto cypionate) and other trans men I’ve heard from have said, the gel version is a much slower ramp-up usually because you’re adding T to your system in small, daily doses, and the cream version seems to be pretty uncommon; both of them are better if you really want to ease into the changes instead of just getting the whole second puberty thing over with, or if you’ve already been through testosterone-dominant puberty and just need to maintain your levels.

Since July 2017 I’ve been on a weekly 0.4 mL injection of 500 mg/mL testosterone cypionate. It was pretty challenging at first with my phobia of hypodermic syringes, but I’ve inured myself to it over time. My habitual injection site has also acclimated to it so that there’s literally no pain at all if I get myself in just the right spot, so that’s pretty great; and using the bathroom mirror instead of looking directly at myself has proven a great little trick to hoodwink my brain about what’s going on, thus reducing my anxiety about it a great deal.

I’ve stuck with it because it gets results, it’s a lot less messy and aggravating than a topical treatment, getting the right dosage is MUCH easier, it’s become a little ritual of sorts, and I only have to remember it ONCE a week instead of seven times. It’s also lessened my anxiety when I have to get blood drawn or have IVs in (though I still really fuckin’ hate IV lines). YMMV, but for me, it’s been a great experience overall.

We’re not gonna talk about the thinning hair, though. -_- One more crappy thing I inherited from my dad’s side, and wouldn’t you know it, it’s activated by testosterone….

[windwardstar]

that one t post

Since there's some of y'all who showed interested, here's the big rundown of my experiences with T. This covers being on T for 3 month at 26, stopping it for a few years, then the first 9 months of being on T at 28. Contains the changes that have happened while I’ve been on T + the interactions with my other health conditions + the process of accessing care. It’s safe for work/reading in public as far as any puberty/medical body talk is. Word count is ~8k.

T round 1 (2019 - I was 26)

If you followed me back in 2019, you might recall me getting on T at the end of that year.

I didn’t have a PCP and was in a very conservative state which made me concerned about finding a trans friendly provider, so I decided to go through Planned Parenthood knowing it was informed consent. The PP that had a gender clinic and was open on my day off was on the other side of the state/2 hour drive one way. But also, when I went to book an appointment they had one for the same week/the next day so I didn’t have to wait. I had insurance through my work that partially covered the visit, the lab work, and the prescriptions. This was out of network for my insurance so I paid more than if it was in network. My local pharmacy was the Sam’s Club which has $4 prescriptions for members- which is what I ended up paying as it was significantly cheaper than my insurance co-pay. (I did not get a prescription for a sharps container and bought one from the local store.) I got my supplies in 3 month batches and didn’t have any issues with the pharmacy.

At the appointment, I was given a big packet of “side effects” (aka the desired results) it included a handy chart of when certain changes would likely happen. My provider went over it with me to make sure I knew what to expect, and asked me a couple questions about my gender identity and transition goals to get a feel for me and make sure this was what I wanted. I was completely out at work and socially. I had very recently moved out of an abusive homelife and was catching my feet mental health wise, but I was in therapy at the time and on medications that had been as a consistent dose for about a year (aka: mental health problems were well controlled), so the doctor was comfortable prescribing me T. We decided to try weekly injections first to limit potential high/lows on a longer dose cycle.

The Labs for this provider were Initial Labs, 3 Months, 6 Months, Then Yearly. My 3 Month Labs hit right at the start of Covid Lockdown, I wasn’t able to get in for them (perpetually overlapping quarantines at work yo), the shift to telehealth hadn’t happened, and then I ran out of my psych meds (antidepressant and an antipsychotic/mood stabilizer) so my executive functioning skills went bye-bye for a while. So I couldn’t get my prescription renewed and had to stop T after like 3 months. 

I took Testosterone Cypionate (0.25 ML, 0.50 MG) by Intramuscular (IM) Injections in my thigh once a week. The syringes had a twist on/off for the needles themselves (bigger one for the drawing up, smaller for the injection). They hurt a lot for me. I’d get a bruise around the injection site and the muscle would be very sore for 2-3 days after and hurt when I walked or used the muscle. It wasn’t enough to make me want to stop, but it wasn’t pleasant.

(Because of the long drive, the doctor didn’t have me come back for the first shot, just confirmed I was comfortable administering it myself and knew the process. She said if I ran into problems there were youtube videos I could look at or I could call.)

I did have issues with my needle phobia, but before getting to the part of actually seeking out access to T, I’d done a lot of work to manage it. The few years prior to starting T, I’d had to get a lot of blood drawn for lab work, several IVs, and quite a few vaccines which had helped me calm down so I was no longer having panic attacks around needles. The biggest thing that helped though was mental work and visualization. I started out just contemplating the concept of T injections in the abstract, then read posts with people talking about injections, looked at visuals of needles/syringes and people administering them. The last step was then thinking about giving myself injections and visualizing it. The whole time I tried to associate it with all the positive things I’d hoped to get from T and reminding myself the injections/ivs/blood draws of the previous years had all been perfectly fine and my anxiety was not reflecting what actually happened. (I also got a tattoo a month or so before I started T and after the initial anxiety I was mostly just fascinated by watching the tattoo gun, which was what really made me think I could do the T injections.) It took a long time to get to that point. When I started, I was only able to think about needles for a few seconds at a time. But I was able to give myself my first T shot with only a little anxiety (my hands shook a lot). And with each successful injection, the anxiety went down.

The Changes on T (1-3 Months):

Increased body hair. I noticed the hair on my thighs thickening and darkening around the injection sites, but not really much else. The peach fuzz on my face increased and I got a few dark hairs but there wasn’t really anything to shave. I think I shaved my face once because I wanted to not because there was anything to really shave…

Voice Changes: I sang quite a bit so I noticed that my lower register got fuller and the lowest end of my range got easier to access, but other than that there weren’t any vocal changes that I noticed. I didn’t get any voice breaking or cracking.

Bottom Growth: Yeah, there was some of that. Enough I noticed. Things also got very very sensitive and painful. OTC pain meds and ice packs helped. Loose clothes. Also manspreading. 

Periods: They got lighter and less painful almost immediately, and I skipped one 3 months in. Then I ran out of T and got my period back the next month.

Acne:  I didn’t get acne until the 3 month mark or so, but that also coincided with the start of wearing masks. It got really painful so I started using the OTC acne cream I used in high school, and it cleared up to something manageable once I was off T. (My teenage acne hit HARD at 13 and didn’t clear up until I was 24.)

Nightmares: The first month I started getting a significant increase in nightmares/remembering them upon waking up. This may have been because I had just moved into my own place and escaped an abusive environment, but my therapist at the time mentioned that nightmares were a common thing for people starting T (it is a big hormone change so y’know).

Other Changes: there may have been some, but it’s been a few years so I don’t really remember.

T round 2: 9 Months (2022 started at 28)

The goal was always to get back on T. It just took a while. Cross country move (liberal state now yo), new job, getting new insurance. Once I did, I had to figure out where to get T again. The planned parenthoods were all booked months out and none open for gender clinic stuff on my days off. 

I went through my doctor’s office, found out they have a special gender health program for trans people and transferred care to them. I had to wait like a month to get an appointment, but it means my PCP/GP is versed in trans care and does all my hormones. The experience is fantastic. The whole office used my chosen name and pronouns before they got legally changed and had the ability to change the display name on my chart so everyone would use the correct one.

The initial visit was via phone. It was a lot of the same causal “tell me about yourself and your transition goals” as the last time. We skipped a lot of the “this is what t will do” since I already knew it, and folded it in with talking about my experience being on T previously, what I liked, what I hoped for, what I found difficult, etc. I was off the psych medications I had been on the last time, but since I’d been off for two-ish years and was stable, I was ok to restart T. We started me off on the same dose and frequency I had been on previously, but because the IM had been painful, we switched to SubQ.

I didn’t need any initial lab work done, but I’ve done them every 3 months after starting. I had to go in person to pick up my prescription (which I did the next morning after my initial telehealth visit, the pharmacist called the insurance to get the authorization & everyone there was super great) and meet with the nurse to administer my first shot. The doctor poked her head in to say hi in person.

My insurance covers the visits, lab work, and prescriptions. I did have to get prior authorization and have a letter from the insurance company stating my T prescription is approved for a year. I got a prescription for a sharps container this time since the stores did not have any on the shelves. (The pharmacy was out of the small ones too, so I ended up with the big gallon size. It takes up a ton of space under the sink, but it should last me several more years before I have to dispose of it.) My needles also just have a smooth pop on/off to attach to the syringe.

For the first six months, the depo was a 0.25ML/0.50 MG SubQ injection once a week. Because there were certain changes I wasn’t seeing, at 6 months my dose was increased to 0.40ML/0.80MG SubQ once a week.

The SubQ injections basically don’t hurt after I’ve injected them. A couple times I injected them too quickly (just sticking the needle in and pressing down on the plunger too hard and forcing the liquid in, then pulling the needle out immediately) and those are when I’ve noticed redness, swelling, and soreness around the injection site. So my process for minimal pain and bleeding: wait until I’ve got cool skin (not right after a shower), inject slowly, count to 10 before pulling out the needle. Warming up the vial in my hands so the T isn’t cold and making sure everything is dry from the alcohol swabs before injecting also helps with the initial injection pain.

The anxiety around needles has basically all disappeared so I have no issue giving myself injections.

(I have a problem with my T vials crystallizing. I’ve found they take ages to dissolve, so I stick them in a pocket/waistband to keep them warm against my skin for an hour or so as I go about my morning, shaking it every now and then to see how it’s doing. I do my shot on my day off when I generally have time to do that. This time it’s Fridays. Last time it was Wednesdays.)

I started T (again) in April 2022 at 28

(Idk how the math works on these changes when you start/stop/restart on T. I wasn’t able to find anything. Probably because there’s not enough data on it. Given the length of the break, the T levels in my system had definitely reset, and I hadn’t been on T very long previously. Some of my changes went faster than the expected timeline, some slower, some about the same. So know there’s a parenthetical +3 months to all of this.)

Voice Changes: I noticed a continuation of the pattern from the last time. My lower register got much fuller and easier. My upper range started getting harder to reach. Nothing cracking or breaking, but there were some notes I was struggling to reach by the time the choir concert rolled around in mid-May. I started off bordering soprano/alto and was clinging to the alto range before we broke for summer (1-2 months)

I caught COVID from work over Memorial day (~2 months in) and my voice cracked a bit. I went into COVID being able to talk, was sick for a week, and then when the Covid cleared my voice was fried. I sounded terrible talking. Singing wise, my lower range had extended and my upper had come down, but I was still easily able to slip into my head voice.

Started Summer Choir at the end of June. I spent the first few weeks feeling like the songs were a little low for my range. Then things shifted again (~3months) and my singing range shrank to about 3 notes, I could not reliably open my mouth and make a sound, my breath control disappeared. I had one volume I could sing in, no going louder or softer or the sound would disappear. I sounded like a squeaky clarinet. (I did a very good seagull impression.) It was terrible and I loved every minute of it because it was so euphoric. I didn’t sound like a girl. I was firmly in the Tenor range. I was experiencing the puberty I’d always wanted to. (It was hard to tell with the first drop since it happened while I had COVID, but the second time my voice really cracked, I also had a really dry and sore throat.)

Enter August (~4 Months) my range was starting to re-expand. The low notes/chest voice coming back first. I was also figuring out how to make noise with the new instrument, because speaking and singing is all muscle memory. Which meant everything I knew previously was basically irrelevant at best and counter productive at worst. My brain would know how to produce a note on my pre-t vocal chords, so it would try to do what it had done before and either a) nothing would come out because my vocal chords are no longer capable of producing those notes or b) it would come out but be much lower. (I’m still working on retraining this 9 months in. My mental voice and physical voice do not match. I still think I sound like my pre-t self. Like, the thinking voice in my head sounds like my pre-T voice, it hasn’t dropped yet. Which makes singing difficult because I don’t know intuitively how I sound now. I have to adjust once I start making noise.) I was able to make my way through the concert at the end of August, but there were things too high for me since I wasn’t able to access that part of my range yet.

September/October/November/December (month 5-8) my singing range continued to expand and stabilize, the lower notes got much easier, volume control came back, my breath control returned with practice, and some access to my head range. My voice fatigues easily, but that’s getting better too. The vocal fry/clarity of my voice is getting better as well. I had to stop multiple times per rehearsal over the summer, but by December I was able to make it almost the whole rehearsal before reaching my limit. I do not have a smooth transition between notes and get stuck in low gear so to speak. Pre-t my favorite things to sing were songs where I jumped around my entire range. I miss that flexibility, but there are new things to enjoy singing now. I’m also only 9 (+3) months in, and my voice is going to continue to develop. My goals right now are just to continue exploring my singing voice as things change, and to try and get my brain to match what the new pipes can do. 

(January 1st, Month 9 (aka today while I was waiting to do a final round of edits on this post) I had a moment where things finally clicked into place for my singing voice. I was singing while doing the laundry, and I was just able to actually sing without feeling any strain. It felt easy and natural coming out. I had to focus on what I was singing to a degree, but not to the exclusion of doing other activities. The sound didn’t crack or disappear on me, and I didn’t run out of breath mid phrase. I was able to actually sing. It was also a moment where I was able to hear my voice and think “this is what I sound like, this is my voice” as opposed to the transitory state it’s existed in since I first started noticing changes. It’s also just a sense of feeling completed and right. I cried, and there was joy, but the predominant emotion was just feeling that things had finally aligned into where they were meant to be and an overwhelming settling peace.)

My biggest thing right now is just how much more air it takes to make sound, speaking or singing. My laugh has turned from a giggle to just blowing air out through my teeth or a bunch of kekekekeke where the sound is from my tongue stopping the air rather than my vocal chords making noise. Singing, I am having to breathe much more frequently than before. Speaking, I sometimes don’t do enough air and sound doesn’t come out. I go nonverbal A LOT more than before because the physical act of speaking has become harder. That initial start up to making noise is sometimes more than my brain can figure out in the moment.

My speaking voice has also changed a lot. The pitch has dropped, it’s gotten much rougher, but I tend to speak in a very femme manner. People have definitely noticed it’s dropped, but it sounds more “cold/laryngitis” than “guy.” People have definitely started reacting differently when they hear me speak over the phone, but I’ve yet to get any comments and it’s not been enough to keep strangers from misgendering me. I have the ability to sound like a guy, there are times when I am relaxed and can hear it come out. The bulk of how my speaking voice sounds is from how I’m using it. I sound like a girl to others because of all those aspects of speech that have nothing to do with how high or low it is. (Aka sounding like a guy at this point for me is about technique not physical ability. This is where speech therapists would be useful.) My dysphoria over my voice has essentially disappeared. I love my voice now, and I’m filled with so much excitement over seeing what else unfolds with it as I get used to it and how to use it. 

Acne/Skin Stuff: First off, Puberty 1.0 gave me terrible acne. It set in at like 13. Regardless of what I did as a teenager, I was unable to really control it. I had products but they didn’t really work and my mother wouldn’t get me to a dr for it. My skin was dry and oily. It would crack and peel and bleed and had reactions to every product I put on it. It got better in my twenties and was mostly gone by the time I was 24. It came back when I started T the first time + Covid Masking at 26. But by that point I’d found an acne cream + lotion combination of products that kept things almost clear.

I expected to have acne bad again on T because that’s just what my body does with hormones. By the end of the first month the acne was back. It progressed to being painful cystic acne by 3 months. I told my doctor and got a prescription cream. I’m meant to use it twice a day, I did at first, but it made my skin too dry, so I use it mostly once a day (generally after I’ve showered). I use it + a plain lotion for moisturizing/keeping things from getting too dry. I still have pretty bad acne, my face is red and skin is perpetually breaking out. But it’s not painful, and that’s my biggest goal with controlling acne. Especially because I react very strongly to products on my skin.

My acne still gets worse around my periods, so I know a lot of it is hormonal stuff going on. There’s some slight increase in body acne, but nothing that I even have to put cream on as it’s not painful and goes away on its own. The acne usually appeared in spots where hair was growing in for like a week or so while the hair started growing in thicker/darker.

The rest of my skin also got super oily. And I got super sweaty. And smelled funky for a little while. Previously I showered and washed my hair every other day because that was the balance of keeping my scalp happy. My skin also couldn’t handle more than that as it would get too dry and crack even with lotion. 1-2 months in, I was showering every day, over the summer (~3-6 months) I was showering once in the morning and once at night (mostly because sweat, but also smell) and washing my hair every day. I did not really experience any dry skin. Somewhere around the 7 month mark, that all decreased. 9 months in, I’m showering every day (with an extra shower if I get gross) and still have no problems with dry skin on my body.

The T has affected my scalp*. I started reacting to the shampoo I’d been using for years about a month or so into starting T. I switched to a different shampoo that worked for the most part, but then started causing problems about 7-8 months in. I’m currently trying a new shampoo + washing every other day or so, and hoping it works. This is getting brought up at my next appointment either for medicated shampoo or a referral to the derm if the current shampoo doesn’t work. *I don’t know if it’s causing a reaction to the products, or if there’s some interplay of the increased oils + increased sweat + my hair being wet for longer + more washings causing more dryness and more irritation + the hair dryer causing more irritation. All I know is my scalp is hurting and I am trying to figure out why + what I can do to make it stop.

Aka: I had terrible acne during puberty 1.0. Puberty T.0 is running about the same in terms of getting acne, but I’m able to manage it so much better because I’ve a) found a lotion I can apply to my face to help with the dryness and b) got a doctor to prescribe acne cream that actually helps. I’m having worse scalp problems now though, but working to manage them.

Facial Hair/Body Hair/Head Hair:

I started getting dark hairs on my chin first. It was within the first 3 months. It also coincided with the acne. Because my skin is so sensitive and the acne was so bad, I decided to use an electric razor since it doesn’t cut as close and tends to result in fewer nicks and cuts and ingrown hairs. I would not have been able to use a razor without cutting myself at the start. I also tend to react to shaving cream so the electric razor allowed me to not have to figure that aspect out too. I started off every few days, then every other day. Somewhere around 6 months I started needing to shave every day to keep the stubble away. If I have a few days off in a row I’ll skip the shaving so I can see what it looks like, but I shave clean if I have to work.

I’m not really sure when the body hair started growing. I noticed the leg hair on my thighs started growing in a little thicker and there was a bit more hair on my belly 4-5 months in (mostly because the bandaids from my shots started hurting when I pulled them off lol.) At 9 months I’ve noticed the hair on my arms and thighs has gotten darker and a little thicker, and my belly has gotten a lot more dark and thick hair, and there’s some chest hair appearing. I want to say somewhere around 6-7 months, I really started noticing the body hair and getting euphoric and happy about getting fuzzy. (Idk about lower leg hair since I frequently shave it due to wearing compression socks and finding them sensory hell and painful with leg hair.)

(Also got more hair on the butt and the butt crack, which was making getting clean after pooping during colitis flares difficult. Solution I’ve found is shaving/trimming that area (you know how it works with long-haired cats and dogs?) and using wet wipes if needed.)

One thing I did notice for both my facial hair and body hair, is that my skin would get mildly itchy the week or so before I started noticing more hair growing, and would continue for that first week or so + there tended to be some ingrown hairs during that stage. It was rather similar in feeling to what my underarms or legs feel like when I shave them and the hair starts to regrow. The itchiness is pretty mild for me so I didn’t really do anything about it.

The spot I inject the T got darker thicker hair first. And by spots I mean like the circle immediately around the injection sites was noticeably darker and hairier than the surrounding body part. It’s evened out on my thighs since my SubQ are in my belly, and the belly is starting to even out 9 months in.

Head hair. It’s started thinning up top right around my part, and on the sides of my temple. Really only noticed it starting at the 8 month mark. I’m currently in the process of trying to figure out if this is related to the scalp issues (since they can cause hair loss) and reversible, or the permanent slow march of time kind of balding. I really like having long hair. It’s fun. I haven’t cut my hair (which would improve my chances of passing as a guy or at least not getting consistently gendered as a girl) because I like my hair. I want to keep it. 

I know finasteride and minoxidil are both things that can be used to treat it. I’m hesitant to use finasteride since it blocks DHT and I want the effects of that more than I want to keep my long hair. I’m worried about minoxidil exacerbating my scalp problems and causing more hair loss. 

I’m contacting family to find out more information about family history of hair loss (including the ones where there were auto-immune skin conditions that caused it) and will talk with the doctors to figure out what the best option for me is.

I was a lot more anxious about the potential balding when I first noticed, but after a couple months to process it I’m not as alarmed as I was. If I do go bald though, I like the idea of getting tattoos. It’s also something that hopefully will be slow enough that I’m not gonna lose everything right away and can still enjoy having long hair for a while. But also you know the meme, if you can’t produce your own, store bought is fine. Wigs do exist.

Muscles, Fat, and the whole Musculoskeletal Shit

My timeline on this is a little blurry. Mostly because I’ve always built muscle easily and been rather buff just through having jobs that require some level of physical labor. I’ve also got hypermobile joints + low back pain from falling down stairs in 2019 + chest, rib, & shoulder pain from binder (haven’t been able to bind since pre-pandemic) and bra. So my focus on/awareness of physical ability was less on ease of strength and more on whether or not I had pain that made breathing/movement difficult. I’m going to guess it was easier to build muscle fairly early since I did notice some other changes that would track with things being affected.

So first thing I noticed was that my hips weren’t as prone to slipping out of place as usual and the days where they were painful decreased as well as the level of pain. It got to a point where I basically wasn’t having hip pain except around my period (pre-T the pain would get worse around my period, this is a continuation of the existing pattern). I’m not sure if I noticed this by 3 months, but I did by 6 Months. My guess is that the T strengthened the connective tissues and helped build muscle to hold everything in place. When I did a lot of walking and fatigued my leg muscles, the hip pain would get worse pre-T, but now I don’t really notice that at all 9 months in. If I get sore after movement, it doesn’t knock me out for several days. I still have to be careful about how I’m sitting and sleeping as the joints can still get knocked out of place that way. But also, the threshold for pain happening is much higher and I have fewer days of it. I’ve also only had to use my cane a handful of times since starting T.

My rib/chest pain got less severe at some point… I know I’m able to tolerate wearing my bra all day without feeling pain most of the time. That shift happened some time over the summer. So 3-6 months. (This was because my body finally managed to heal from the injuries from binding and the stress injury from using the deli slicer 2-4 hours a day at work in 2018.)

My back pain has kind of been figuring out what makes it worse and better. It’s gotten better overall over the past 9 months, but idk how much I can attribute that to T and how much is just figuring out what makes it worse and not doing that. 

I’ve also noticed a significant decrease in flexibility. To the point I can stretch muscles I’ve never been able to stretch before. I can stretch my muscles without hyperextending joints. I started to resume a lot of the stretching I stopped in 2018 because whatever support my joints now have is enough that I don’t risk being too bendy to hold them all in place. My hands basically don’t dislocate/sublux any more, and the pain in them is gone. My grip strength has never been better. I can open water bottles without fucking up my fingers. (Aka T has definitely helped with the hEDS.)

My skin has also gotten thicker and less prone to getting cuts. If you follow me, you probably saw the post I made about the changes on that, but basically, my skin is tougher. It doesn’t get cut up as easily and I don’t bleed as easily. My mouth doesn’t get cut up as much by rough foods like toast and cereal and brushing and flossing doesn’t cause bleeding and tearing (no gum health issues this is just hEDS stuff, although I also notice the sensitivity of my gums fluctuate with my period), I don’t get papercuts as easily, sewing is a lot less bloody. This has made it slightly harder to put the needle through my skin for the T injections, it used to go in completely painlessly but somewhere around 6 months it started pinching a bit.

I also have a little adam’s apple now! Which I wasn’t expecting since I’m nearly 30 and I figured things wouldn’t shift too much. I started noticing it grow 3 months in or so when I would touch my throat and it slowly got just a bit bigger. 9 months in there’s something visible in my throat when I talk or swallow, just a tiny visible bump but it’s more than it was before! It also tends to sit REALLY high in my throat, which I know is also part of the problem I have with my voice being high and strained. I have a couple vocal exercises that lower it and my voice and reduce strain. But also this was one of the things I wanted but was realistically not expecting to get so !!!

As far as muscle and fat (re)distribution and such, I noticed somewhere around 4-5 months that when I looked in the mirror after showering so a) i didn’t have my glasses on and things were hella blurry and b) the mirror was somewhat fogged, I had a more masculine look. When my hair covered my chest (it was waist length at that point) there was just enough shifting of things to look masc. (My boobs have gotten somewhat flatter/deflated. Around my period I definitely get a feeling that they’ve gotten bigger/swelled back up.) 

Body wise, my shoulders have always been broad, and the ratio of tiny waist to huge hips has always been a source of dysphoria for me. There’s nothing T is gonna do about the underlying bones, but I have noticed my hips and thighs slimming down somewhat / my waist filling out. It’s changed my silhouette away from the hourglass and into something more masculine. It’s helped greatly with my dysphoria when I see myself in the above sink/counter level mirrors. (Full body mirrors/reflections are still hello dysphoria hips.) 

My shoulders also got slightly broader, my neck thicker, and my feet got slightly larger. I know for sure around 5-6 months, as I pulled out my long-sleeves for winter and the ones that had been tight and with no stretch the previous year were too tight to wear comfortably. I also pulled out my performance clothes which I hadn’t worn since month 2 on T, and had to let out the collar on my bowtie by a solid inch and get new shoes as the previous ones were too tight (again I’m almost 30, my feet bones didn’t grow but I did have to go up a shoe size).  I had thought around 4-5 months that my neck was getting thicker since it didn’t look quite as stick-like. Around that time my face also started looking a little swollen around the jawline. It may have been puffiness or just things shifting around. I’m faceblind so I don’t know if my face has changed, just around that time looking at my face made me think the jaws looked a bit like my sister’s did a week after getting her wisdom teeth removed. Whatever puffiness I saw then, I don’t notice now though.

Idk if I’ve gained or lost weight since I don’t own a scale and don’t actually pay attention to that because it’s not actually important. Shrug emoji. 

Periods & Bottom Growth:

If you’ve read this far you’ve probably guessed my periods didn’t stop early this time. As I stated, the first attempt at T, they stopped three months in. My third period came two weeks early this time when I caught COVID. We increased my dose at 6 months because my periods hadn’t stopped. My 8th period happened a week late. This month for the 9th I’ve gotten some light cramping and joint pain (but another week or two will tell if it’s stopped).

I did notice by 6 months the pain/cramping and other things associated with my period were less. (The flow decreased somewhat and the cramps were less severe. I was able to still walk and function with the OTC pain meds, and I had to take fewer for a shorter time frame to get relief. My blood pressure didn’t tank as drastically, so I wasn’t at risk of passing out every time I stood up on the first few days of my cycle each month. I didn’t get chills and shaking. I still get increased acne, bloated, migraines, and my joints all get loose and painful.)

(Outside of my period, my POTS has also drastically improved. Around 7-8 months, all I really started to notice is the tachycardia. The blood pressure problems aren’t forcing me to sit down to avoid passing out, my low blood pressure migraines have mostly disappeared, and my heat intolerance has drastically decreased. The heatwave in 2018 is what ended up with me in the hospital. I made it through the heatwave this year without too much difficulty. I still get migraines when I get too hot, and get weak and exhausted, but I recover within a day rather than a week. My migraines have tons of triggers, but overall I’ve gotten fewer of them since starting T. The only trigger that’s increased in causing them is my low blood sugar.)

Bottom growth has happened!!! I was ambivalent to slightly apprehensive about this part prior to starting the last time, but discovered pretty quickly I was actually really on board with it. For a while this time I was worried starting/stopping/restarting T meant I wasn’t getting any this time around. But the past month or so (month 9) has given me indications it was just taking a while to happen (like my periods not stopping 3 months as previously). This time, I haven’t experienced much in the way of pain + too much sensitivity, but the sensitivity has really increased in the past couple weeks so that may start again as well.

Appetite & blood sugar :

The increased appetite has probably been my biggest most noticeable thing in my day to day life and the only thing that has actually caused me distress (as opposed to annoyance and irritation with the acne). I noticed pretty quickly an increase in my appetite. This brought back problems with my blood sugar just crashing (and tanking my blood pressure with it) that I’d had while growing up. I would also wake up hungry in the middle of the night. 3 Months in it was the biggest change I noticed. 

6 months in I was up to eating every two hours, waking up twice at night, and if I skipped one my body would get ravenously hungry and would have headache and shaking. But I was also getting more used to the routine so I got better about keeping food on me and my blood sugar didn’t crash as often/as severely. My grocery budget effectively doubled so that was yikes to my bank account. I also couldn’t get full or stay full. I was constantly hungry. Since I had a history of food insecurity as a kid, the constant feeling of hunger was distressing and started making my anxiety and ptsd get worse. 

(There is a link between testosterone levels and blood sugar. Most of the data is on cis men. But the little information packet that comes in the box of my testosterone vial includes: In diabetic patients, the metabolic effects of androgens may decrease blood glucose and therefore, insulin requirements. Presumably, the doctors know to monitor this with diabetic patients and to mention it to them. But also, a reminder to read all the paperwork you’re given because neither of my prescribers mentioned this aspect to me, even when I mentioned having problems with my blood sugar dropping.)

9 months in, my appetite has decreased to pre-T levels which also coincided with getting heart burn/acid reflux for a solid week and a half. I’d never had a problem with that before, but I was also eating/drinking and then immediately laying down (aka eating right before bed and a midnight snack) for like six solid months, which is a big clue to the cause. The biggest surprise there is that it took six months to become a problem. I’ve been mindful of staying upright after eating and after a few days the problem went away.

Dysphoria, Mental Health, Mood and Energy;

T has been fucking amazing. Like. It’s fantastic and I’m thriving and have never felt so stable and capable of handling life. I can’t attribute everything to T because I’ve done a lot of work on my own mental health and my living situation improving (moving away from abusive family, getting engaged with friends and community, fulfilling job) but its positive impact on my mental health and general mood is undeniable.

My dysphoria is so much less than it was before. I love my voice now, I am starting to remember what it feels like to be comfortable in my body. There’re still a bunch of things that are dysphoria inducing that will take more time or surgery (top, hysto, bottom) to change and relieve, (and when I am reminded about the dysphoria inducing things like boobs and people misgendering me as a girl, it feels terrible and I want to crawl out of my skin). But the entire experience of being on T has been a daily blessing of euphoria as everything happens. 

I used to joke that you knew trans people were really trans because who else would willingly go through puberty a second time. Puberty 1.0 had been soul destroying terrible. I hadn’t had a single positive experience from it. Everything about puberty 1.0 had made me hate my body more and the changes just kept getting worse. I couldn’t imagine anyone willingly going through that a second time. Somehow despite knowing I wanted all the changes T would cause, my brain didn’t make the connection that I’d like the process aka puberty 2.0. I’d figured I’d suffer through puberty again and in the end I’d have a body I liked and was comfortable in, so it’d be worth all the suffering of puberty.

I was terribly wonderfully wrong. The first time I was on T, I didn’t really notice a ton of changes, but even the small ones I did I liked. It wasn’t terrible. And then, I was off T and the strength of my desire to get back on T and go through those changes was a physical ache. The past 9 months have been full of joy and excitement. Every little change I’ve noticed has made me happy and been something I loved to find. (Barring the acne, and hunger, and potential hair loss.)

Puberty 2.0 is so powerfully positive for me. I love it, and it’s letting me love my body.

My mood is a lot more stable than it was. With my dysphoria lessened, I’m not constantly feeling shitty about that which overall helped my mood. I’m not as depressed (and when I am, it’s so much more mild than before). My mood tends to be either in a stable state or hypo/manic. But there’s no irritability or violence or any of those fear mongering things. T didn’t suddenly change me into the TERF and bio essentialist’s boogey man. T doesn’t change your personality. If you have anger issues on T, you likely had them before. (Also I really want to stress this because I saw warnings about T and bipolar disorder for years: T did not make me irritable or angry or violent. It hasn’t changed the profile of my mood disorder to include symptoms that were never present.)

(As for crying. I don’t cry out of frustration or anxiety as much--which is likely because my mental health has improved and I’m not pushed into those strong negative emotions as often. But I tear up just as easily when I see heartwarming news stories or videos of puppies or see something heartbreaking on the news. I haven’t been cut off from health emotion, or healthy crying.)

Energy wise, I have so much more energy than I did before. I’ve managed to wake up easily all winter rather than take an hour to drag myself out of bed every day. I can work a 12 hour shift, and/or not take a nap and be fine with 8 hours of sleep (or less) at night. I can run around and do things on my days off. I have enough energy to function. I don’t have to have an entire day off just to sleep (although I still enjoy a good afternoon nap and sleeping in). 

I don’t notice my energy level fluctuating with my shot (I do weekly injections to avoid my levels fluctuating and causing other things to do so as well), but I did notice my energy levels increased within the first month. But! There’s also a lot of other things going on that are affecting my improved energy levels. Some of this might be because I actually started taking a vitamin d supplement (and I definitely notice less energy when I forget it). The lessening of my dysphoria has freed up a lot of mental energy for other things, the lessening of my dysphoria has lessened my depression* which gives me more energy, the reduction in joint pain + other chronic pain means I’m not constantly having that low drain on my energy and resting better at night, and the reduction in POTS symptoms means I’m not having that massive daily drain on energy reserves.

(*I’ve noticed an increase in energy at my stable baseline, and an increase in the sustained energy while hypo/manic from my pre-T mood cycles without an associated increase in the severity of other symptoms. My depressive moods have reduced in length and severity because there aren’t as many things fucking triggering me during them (which can also be attributed to the better living conditions and social connections, since I noticed this prior to restarting T), but I also have an increased energy during them as well. Which all tracks with the physical conditions improving and no longer draining my energy as much.)

(I still notice when my blood sugar drops, I get my period, or I have an anxiety attack that my energy levels for the day drop accordingly. But I’m also quicker to bounce back to my new baseline. My anxiety has more or less stayed the same. Also randomly feeling tired has become a much more reliable migraine aura because now being tired tends to have an easily identifiable cause.)

As I mentioned in the appetite section, there has been some downsides to my mental health while on T. The constant hunger was triggering for me, but since I'm in a stable environment and have money for food, it’s something I’ve been able to work through. I’ve also experienced more nightmares since being on T, especially around when I first started and when my dose was increased (biggest changes in hormone levels). But the nightmares also increased in general, which I also want to attribute to having more energy while on T. Before T I had a tendency to be so utterly exhausted I didn’t dream and/or I woke up too frequently during the night due to joint pain/needing to reposition that I didn’t complete sleep cycles and wasn’t dreaming/having nightmares. (The biggest argument for this is also that I’m straight up actually having non-nightmare dreams now too. I rarely had dreams and/or remembered them before. I get them decently often now. Which is nice! Dreams can be fun! And weird. Dream logic does not make sense upon waking up.) 

“Passing” / How people perceive my gender / General Reception

Gender is a party and transitioning is the grab bag. I’m basically completely on board all the physical changes T is making to my body (bar the acne and the balding). Presentation wise, I lean heavier into the men’s clothing than the women’s and would prefer to be read as a guy rather than a girl if people gotta gender me, but I’m not a guy and not actually interested in passing as a guy. So I don’t put any effort into passing as a guy. Being my authentic self and transitioning into my nonbinary genderqueer gender basically means I do what I’m comfortable with and just vibe (until someone misgenders me and then I dark side dysphoria vibe). 

Basically for those keeping track: I have long hair, I shave clean (and wear a mask anyway), my boobs are still visible (can’t bind), my hips are still a thing, and my voice sounds mostly like I have a cold (lower but with girly customer service inflections). My chosen/legal name is still femme. I’m also 5ft/160cm and relatively small. I dress in men’s clothes for the most part. Strangers still assume I’m a girl. Even in trans friendly spaces I get she/her’ed by default. 

(I’m out to management at work but very few others. There’s been maybe one person who might have noticed something. Most people I interact with through work--if they notice anything-- notice my voice change. But all the comments I’ve gotten indicate they think I’ve strained my voice from singing, have a cold, or it’s related to my breathing problems. (I had to wear a mask/scarf outdoors before covid due to the cold making it impossible to breathe, same with smoke. Also I caught COVID right before my voice cracked so…))

As I said, I don’t bind and my hair is long and don’t try to pass as a guy, so it makes sense I won’t. I’m sure if I had short hair and didn’t have visible boobs the default gendering by strangers would shift to a different percentage of girl vs guy vs awkward pause as they guess. So if you’re wondering how long it’ll take you to pass as a guy or confuse everyone, I’m not gonna be too helpful. But if you were concerned about being able to hide being on T/keep your transition on the DL until you’re ready to come out, you can definitely do it, just come up with some excuse for your voice because people will notice that.

Congrats I guess if you’ve read this far. Hopefully this was helpful and/or informative. The TL;DR of it is that the bulk of the changes kicked in somewhere between 3-6 months and are gonna continue for another good while. It’s having a lot of positive effects on my various health conditions (POTS, hEDS, migraines). I’m having a blast with everything that’s happening and am delighted by puberty 2.0. The drawbacks are just kind of inconveniences (and aside from potential balding, seem entirely temporary) and are nothing compared to the overwhelming joy and euphoria of slowly getting to exist more comfortably in my skin.

if you've got questions, feel free to ask. Just know depending on the question and whether or not I even know who you are will influence if I answer it or block you.

tagging myself so i can reblog if i need to @owlsofstarlight

[genderqueerdykes]

Helloo, could you explain the diffrent types of testosterone like as in androgel, sustanon, all that stuff. I'm thinking of going on sustanon but I don't see quite alot of info except for cis guys using it for bulking and im afraid it's not quite a good comparison for ftms

i am not familiar with sustanon, so i will have to do some research and return to you at a later time, as well as see if any other anons or anyone in the comments can help for the time being. also i typically tend to recommend the subreddit community r/ftm, they are great for asking questions about different forms of T since so many guys use it =)

i have personal experience with androgel, and injectable testosterone cypionate. i used injectable T subcutaneous, meaning I injected into fat/skin tissue, and not intramuscular/into muscle tissue, due to my intersex condition and natural testosterone levels. I'm not sure how commonly this method is prescribed to people, but I have always been instructed to do it this way, as I've been told it will lead to less prominent up-and-down spikes and fluctuations of hormone levels. I'm not a professional though so I can't verify as to whether or not this was just that one professional's advice, or if that's 100% accurate.

again, for me as an intersex person, I don't know how applicable that is to perisex trans people, as i know most perisex transmascs inject intramuscular. that being said, testosterone cypionate is generally the go-to, it's strong, it's effective, it's kind of what everyone pictures when they think of T. the only thing to keep in mind about injectable T is pharmacies don't always give you the correct gauges of needle. generally you want 2 different gauge of needle, one larger and thicker to draw the T from the vial and a smaller thinner one for injecting, but pharmacies are really bad at giving you both, and giving you the correct gauges of both. this is easily the biggest pain with injectable T. if you have needle trauma or just don't want to have very strong spikes of testosterone and very strong drops in your hormone levels leading up to injection day, a gentler option is topical.

i've personally used androgel and i really like it, that's actually what i'm using right now, as i've been injecting for 7 years and my doctor wanted me to move away from that to avoid potential tissue damage from years and years of poking my skin. i really like androgel, although for some people it is less effective. if you have very low natural testosterone, or, your body is just poorly receptive to the hormone and doesn't take to it easy, it make struggle to benefit as much from topical testosterone, however nothing is stopping you from asking your clinician to try the topical T at a slightly higher dose to see if you just need a boost when using it transdermally. your dose isn't going to be the same on an injectable format as it is on a transdermal format

i get a generic version of androgel that comes in a bunch of pre-measured tubes so i don't have to measure anything out. i just apply 1 tube two days a week. i find that super handy as measuring my dose with injectable T was sometimes time consuming, especially if the pharmacy gave me the wrong gauge of needle, which they did often. my only complaint is that it's an alcohol based gel, so it smells very strongly when applying it. it literally just smells like rubbing alcohol, which doesn't sound bad, but it smells like about 1 gallon of it at once. that's hyperbole of course but it's just very concetrated smelling. the two areas they suggest applying it are on your abdomen (belly) and on the outside of your biceps (between shoulder and elbow). you can pick what works for you, i typically tend to do it as far away from my face as possible so i'm not dying from the smell but some of my alters put it on our arm because they're too lazy to put it under our shirt so (shrug)

always wash your hands directly after using topical T because you can in fact transfer testosterone to other people by touching them. you're not going to cause them to transition but it's just important to wash your hands to make sure you're not getting it on anyone else. it's recommended to avoid showering or getting into a pool or getting wet or anything for at least 45 minutes, i'd wait at least an hour or more if you can, just to make sure you're getting the most out of it you possibly can. it does leave a residue on your skin, but i notice it's more annoying on your hands than anywhere else. i think some people probably use a glove to apply it but i am broke as hell rn and don't

that's about all i can think of at the moment, anyone else please feel free to weigh in about any other kinds of testosterone or to throw in anything else i missed, like i said, these are the only two forms i have direct experience with. hope this helped some!

[healthlineonline]

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Meeting the Needs of a Growing Population: The Evolving Global Klinefelter Syndrome Therapeutics Market

The Global Klinefelter Syndrome Therapeutics Industry is expected to have a significant upswing, with a Compound Annual Growth Rate (CAGR) of 5% predicted from 2023 to 2033. It is anticipated that the market will be valued at US$ 1.85 billion, a substantial rise from US$ 1.14 billion in 2023.

The unidentified symptoms of Klinefelter Syndrome make it difficult to diagnose, which has led to cooperation between the government and medical institutions like the NIH and FDA. The goal of increasing awareness of this illness is to guarantee prompt action and enhance early detection.

The program is a component of larger incentives for various health examinations, which are expected to be a major factor in the market’s future growth. Increased clinical symptoms in all age groups and a rise in male fertility issues are anticipated to be major factors driving market growth.

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Europe is expected to be the second-fastest-growing region in the industry. The rising prevalence of the disease has enhanced research financing, and health organizations such as the National Institutes of Health (NIH) are focusing on raising awareness about the syndrome, which is cruising market growth. North America is expected to dominate the market due to the region’s large number of testosterone drugmakers, as well as increased awareness among the region’s population. In addition, a large number of treatment centers for this ailment will increase market share over the forecast period.

Key Takeaways from the Global Klinefelter Syndrome Therapeutics Industry Study

From 2018-2022, a CAGR of 4% was registered for the Klinefelter syndrome therapeutics market

By therapeutics, testosterone replacement therapy to experience maximum uptake, growing at a 3.1% CAGR

Hospital pharmacies to remain primary POC for availing Klinefelter syndrome therapeutics drugs, growing at a 4.6% CAGR

North America to emerge as the kingpin, registering a market share worth 38%

Europe to be the 2ndlargest market, expected to accumulate a 34% revenue share

Asia Pacific to show significant growth, registering a CAGR of 5.1% until 2033

“With rising instances of male infertility, the need for seeking therapy and diagnostics to detect the presence of Klinefelter syndrome is increasing at a fast pace. Treatment providers are therefore endowed with an opportunity to introduce more robust approaches, generating many opportunities,” remarks an FMI analyst.

Key Market Players

Key players in the Klinefeltr Syndrome Therapeutics market are Hoffmann-La Roche Ltd., Takeda Pharmaceutical Company Limited, Kyowa Kirin Co., Ltd, Pfizer Inc, AstraZeneca, AbbVie, Inc, Bausch Health Companies Inc, Bristol Myers Squibb Company, GSK Plc, Novartis AG, Viatris.

Takeda Pharmaceutical Company Limited and Seagen Inc. announced that data from the Phase 3 ECHELON-1 clinical trial of an ADCETRIS® (brentuximab vedotin) plus chemotherapy combination would be conveyed verbally at the 59th Annual Meeting of the American Society of Clinical Oncology (ASCO).

In 2021, Pfizer Inc. launched Testosterone Cypionate Injection as a replacement therapy for males suffering from exogenously low testosterone or absence.

Key Segments Profiled in the Global Klinefelter Syndrome Therapeutics Industry Report

By Therapeutics:

Testosterone Replacement Therapy

Fertility Treatment

Surgeries

Hormone Treatment

Others

By Application:

Hospitals

Specialty Clinics

Others

By Distribution Channel:

Hospital Pharmacy

Retail Pharmacy

Online Pharmacies

Others

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[danishkhan786]

Winstrol

Testosterone Cypionate

Isafesteroid.com

Testosterone Cypionate is a synthetic form of testosterone, which is the primary male sex hormone. It is used medically to treat conditions caused by low testosterone levels in men, such as hypogonadism or delayed puberty. It belongs to a class of drugs called androgens.

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Here are some key points about Testosterone Cypionate:

Hormone Replacement Therapy: Testosterone Cypionate is commonly prescribed as a form of hormone replacement therapy (HRT) for men with low testosterone levels. It helps to restore testosterone levels to a normal range, improving symptoms associated with low testosterone, such as fatigue, decreased libido, and muscle weakness.

Administration: Testosterone Cypionate is typically administered via intramuscular injection. The frequency of injections can vary, but it is commonly given every 1 to 2 weeks.

Dosage: The dosage of Testosterone Cypionate depends on the individual's needs and the severity of testosterone deficiency. It is important to follow the dosage instructions provided by a healthcare professional.

Side Effects: Like any medication, Testosterone Cypionate can have side effects. Common side effects may include acne, increased facial or body hair, mood swings, oily skin, water retention, and decreased sperm count. It may also have more serious side effects, such as liver toxicity, cardiovascular problems, and prostate enlargement. These side effects should be discussed with a healthcare professional.

Monitoring: When using Testosterone Cypionate, regular monitoring of testosterone levels and overall health is important. This helps to ensure that the therapy is effective and safe. Blood tests are typically performed to monitor hormone levels and to check for any potential adverse effects.

Abuse and Misuse: It's worth noting that Testosterone Cypionate, like other forms of testosterone, has the potential for misuse and abuse, especially among athletes and bodybuilders. Abuse of testosterone can lead to various health problems and is against the rules of most sports organizations.

It is essential to consult with a qualified healthcare professional before considering or initiating Testosterone Cypionate therapy. They can evaluate your individual circumstances, discuss potential risks and benefits, and provide appropriate guidance and monitoring throughout the treatment process.

Nandrolone Phenylpropionate

Nandrolone Phenylpropionate (NPP) is an anabolic androgenic steroid (AAS) that is derived from the hormone nandrolone. It is a shorter-acting ester of nandrolone, compared to the more commonly known Nandrolone Decanoate (Deca-Durabolin).

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Anabolic Steroid: Nandrolone Phenylpropionate is classified as an anabolic steroid, which means it is a synthetic substance that mimics the effects of testosterone in the body. It is known for its anabolic properties, promoting muscle growth and enhancing protein synthesis.

Medical Uses: Nandrolone derivatives, including NPP, have been used medically for conditions such as muscle wasting diseases, anemia, osteoporosis, and certain types of breast cancer. However, its medical use has become less common compared to the past due to the availability of alternative treatments.

Administration: Nandrolone Phenylpropionate is typically administered via intramuscular injection. The frequency of injections can vary, but it is commonly given every few days to maintain stable blood levels.

Performance Enhancement: Like other anabolic steroids, Nandrolone Phenylpropionate has been misused by athletes and bodybuilders for performance-enhancing purposes. It is believed to increase muscle mass, strength, and endurance, although the use of these substances for non-medical purposes is generally prohibited in competitive sports.

Side Effects: NPP can have various side effects, including androgenic effects such as acne, oily skin, and increased body and facial hair. It may also cause cardiovascular effects, liver toxicity, suppression of natural testosterone production, and other hormonal imbalances. The severity and frequency of these side effects can vary depending on individual factors, dosage, and duration of use.

Legal Status: The use of Nandrolone Phenylpropionate as a performance-enhancing substance without a valid medical prescription is illegal in many countries. It is classified as a controlled substance due to its potential for abuse and misuse.

It is important to note that the use of anabolic steroids, including Nandrolone Phenylpropionate, can have serious health risks and should only be considered under the guidance of a qualified healthcare professional. They can provide appropriate advice, monitor your health during use, and discuss the potential benefits and risks associated with these substances.

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Low-testosterone condition is also known as male hypogonadism in which your testicles don't produce enough testosterone that is responsible for masculine growth & development during teenage years. This hormone is responsible for maintaining sex drive, sperm production, body hair, muscle hair & bone density, etc. Age-related declines in testosterone levels cause older men to typically have low blood testosterone levels, which directly cause erectile dysfunction. When you suffer from low testosterone then this condition or hypogonadism may increase the risk for cardiovascular disease, type 2 diabetes, metabolic syndrome, premature death in older men & Alzheimer's disease, etc. 

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“Sun Pharmaceutical Industries Inc is recalling lots of testosterone cypionate injection due concerns about product impurities and sterility, according to the June 29, 2022, US Food and Drug Administration (FDA) Enforcement Report.

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I haven't seen this answered before, but I apologize if this has been asked already. I've seen a lot of people say that they started testosterone at a low dose, but their dose is way higher than mine, and I'm confused about dosage levels? I've seen "low dose" being described as being around 20-50ml by some people and 200ml by another person. I've been on t for six months and I'm only at 0.3ml? I thought that was a normal starting dose, but now I'm confused. Is my dose abnormally low or...?? I plan on asking my doctor about it, but I won't be able see them for a few weeks, so I was hoping you might be able to clear things up a little until then.

Lee says:

200 mL of testosterone is definitely not a dose that people can take.

Imagine someone trying to inject the contents of this water bottle! You'd need an IV infusion!

[Image description: A mini-water bottle being held be Lee. It says that it contains 8 fluid ounces of water which is equivalent to 237 mL. /End ID]

Even taking 20-50 mL of testosterone isn't possible.

Most people on weekly testosterone injections are injecting less than 1 mL because that is the amount that's typically safe and comfortable for someone to self-inject with.

Large-volume injections of 3 mL or greater are rare, and are not typically not administered in an outpatient setting.

0.2 mL is different than 2.0 mL is different than 20.0 mL. So when we start talking about doses, remember that the decimal point is really important!

Anway, moving on!

If you told me that you're taking 0.3 mL of testosterone, and I told you that I'm also taking 0.3 mL of testosterone, you might assume that we're taking the same dose.

But the frequency of testosterone injections will affect dose comparisons!

If you're injecting 0.3 mL of testosterone subcutaneously every week but I'm injecting 0.3 mL of testosterone every other week, that means that my dose is half of yours because I'm on the equivalent of 0.15 mL weekly.

In the USA, most people doing testosterone shots are doing a subcutaneous T injection once a week, or doing an intramuscular T injection every other week.

So if you're discussing your dose with someone else, and they say that they're taking 1.0 mL biweekly, that would translate to 0.5 mL weekly.

That means you have to be careful about a direct comparison about the volume of testosterone when you're having a conversation with someone!

Ok, now let's move on to another hypothetical.

If you told me that you're taking 0.3 mL of testosterone every week, and I told you that I'm also taking 0.3 mL of testosterone every week, you might assume that we're taking the same dose because we're injecting the same volume of testosterone at the same frequency.

But the concentration of the testosterone will affect dose comparisons!

Most testosterone vials in the US have a concentration of 200 mg/mL. That means if I'm injecting 0.3 mL of 200 mg/mL testosterone weekly, I'm taking 60 mg of testosterone per week.

But not all testosterone comes in a concentration of 200 mg/mL.

My mother is taking testosterone because she has low hormone levels, but because she is cisgender and not looking to have masculinization occur so she's on what you could consider a truly low-dose of testosterone.

Her testosterone cypionate comes from a compounding pharmacy, and the concentration is 50 mg/mL.

So if she's taking 0.3 mL of testosterone every week, that means her dose is 15 mL weekly, which is four times the dose I'm taking.

(At this point, I should note that this is hypothetical-- while my mom and I are both taking testosterone, neither of us is taking 0.3 mL and I'm just using that number as an example).

Ok, so here's another example:

While there are different forms of testosterone, at this point let's just say that we're both taking a more-or-less equivalent form of testosterone like testosterone cypionate and testosterone enanthate.

So if you told me that you're taking 0.3 mL of 200 mg/mL testosterone enanthate every week, and I told you that I'm also taking 0.3 mL of 200 mg/mL testosterone cypionate every week, you might assume that we're taking the same dose because we're injecting the same volume of testosterone at the same frequency and you'd be right.

So now that we've established that we're taking roughly equivalent doses of testosterone, we'd have to get into the blood work.

Equivalent doses don't always produce equivalent results at the same rate.

Two people on the same dose of T might have two different T levels after their first bloodwork, and one of them may have to do a higher dosage while the other may decrease their dosage, but in the end they’d both end up with the same levels even though they’re taking different amounts of T.

People who have a higher dose of T don’t necessarily experience changes faster than people on a lower dose- it all depends on how your body processes the T. The important bit is what your blood work shows your T levels to be, not the dose of T.

So if you and I are both injecting 0.3 mL of testosterone, but my testosterone levels are in the low 200's and yours are in the high 800's, that means that 0.3 mL is a low dose for me and an average dose for you.

There is no particular magic dose that is considered a "low dose" for everyone.

Low-dose T is taking a lower-than-typical dose of testosterone so your T levels are above that of the average cis woman’s, but below the average cis man’s.

If you’re on too low of a dose then there’s some risk that your body will just convert the T into estrogen and you won’t get any changes, or that there could be other health risks, but if you are being monitored by a provider who you’ve discussed taking low dose T with it should be safe.

If you take low-dose T, the changes associated with being on testosterone will take longer to happen but you will end up with all of them except possibly the stopping of menstruation, which happens for some people but not all.

Again, taking low-dose testosterone will still cause genital growth, and all of the other changes listed in the Testosterone FAQ- but your period may continue unless you use birth control, or have a hysterectomy, etc.

People often take low-dose T so they can get used to the changes slower and have time to adjust, or because they don’t want to overshoot their goal of androgyny and end up in the masc side of things.

In my opinion, the term "low-dose testosterone" can be confusing because it gives people the idea that there's a particular dose that counts as low-dose for all people, but sometimes something that's a low dose for one person is an average dose for another person.

Sidenote: While I would prefer a term that addresses the testosterone levels instead of the dose, I do use the term "low-dose testosterone" because while it isn't perfect, it does describe the gist of what we're discussing-- someone being on a low dose (in terms of their own body) and I prefer it to the term "microdosing" which has recently been recently been popularized as an alternative to the term "low dose". The term "microdose" doesn't improve on what I see as the issues with the term "low dose" and it adds a connotation that the term low-dose doesn't have, but that's another discussion.

Anway, I've said a bunch of stuff that doesn't really answer your question.

If you're looking to a way to compare testosterone doses, this table is what you're looking for:

As always, I'd like to note that your testosterone dose should be determined by your testosterone levels, your level and rate of masculinization in relation to your goals, and your overall health (cholesterol levels, kidney functioning, etc), and that is very individual and it means that there may be a reason why your dose is not the same as the dose of the people you've been talking to.

Anyway, with all the caveats listed above, 60 mg of testosterone per week is not generally considered to be a low starting dose (assuming that you're on 0.3 mL of 200 mg/mL of testosterone which would be 60 mg).

I started testosterone on a low dose of gel which was 12.5 mg of testosterone gel daily. This is because I wanted to be on a low dose. I eventually changed my mind, about my goals as I've discussed here, and I eventually went up to an average dose of testosterone gel and then switched to injections.

Now I'm 4 years on testosterone and I'm taking 80 mg (0.4 mL) of 200 mg/mL testosterone enanthate weekly but my primary care provider said my T levels are too high on that dose so I might be moving down to 70 mg (0.35 mL) or 60 mg (0.3 mL) of testosterone soon.

You can (And should!!) bring up any concerns or questions you have about your testosterone dose with your testosterone prescriber.

Since I don't know how often you take testosterone or what concentration you're taking, it's hard to answer questions about your specific dose/situation

60 mg of testosterone weekly is a pretty normal starting dose, and not abnormally low. If your T levels are in the right range when you have your next blood work done, and you feel content with the changes you're experiencing, there's a good chance that you might not even have to change your dose.

But if you were on 60 mg of testosterone biweekly (AKA 30 mg weekly) then that would be a lower starting dose, which isn't abnormal either but it does mean that you likely have room to move up your dose at your next appointment if you aren’t satisfied with the rate of changes you’re getting.

Comparing your dose to other people‘s might be an interesting way to pass the time, and it’s good to be informed on your medical care and check the chart above to see if your dose falls in the low/average/high range so you can ask the right questions about why that is, but it doesn’t mean that someone else’s dose is better than yours if it’s higher, or worse than yours if it’s lower. As long as you’re happy with your changes and your blood work looks good, then don’t stress about the dose!