#infantile spasms

[mcatmemoranda]

I recall two years ago on my peds rotation, there was a baby who was diagnosed with infantile spasms. I just remember the fact that prognosis was poor. It causes developmental regression and delay. It's diagnosed in pts with clinical features and hypsarrhythmia on EEG. The treatment depends on the cause of the disorder. This is from UpToDate:

Clinical features – Infantile spasms, also known as infantile epileptic spasms syndrome (IESS), represent an age-specific convulsive disorder of infancy and early childhood. The triad of infantile spasms, arrest of psychomotor development, and hypsarhythmia is known as West syndrome.

•Most children with infantile spasms present between three and seven months of age; onset after 18 months is rare.

•Spasms are usually symmetric contractions of flexor or extensor axial or limb muscles. They vary in pattern, intensity, duration, and extent. Most spasms occur in clusters of 2 to more than 100 over one to several minutes.

•Spasm or spasm clusters may be unrecognized when they are brief and involve limited musculature. Parents typically underestimate seizure frequency by a factor of 5 to 10.

●Diagnosis – The diagnosis of infantile spasms in a patient with clinical features is confirmed by electroencephalography (EEG).

•The EEG should be of sufficient duration to capture an ictus as well as the characteristic interictal pattern of hypsarhythmia. The recommended approach is an overnight, 24-hour, inpatient video-EEG monitoring study.

•Hypsarhythmia on interictal EEG is an essential feature of West syndrome. The classic pattern of hypsarhythmia consists of very high-voltage, random, slow waves and spikes in all cortical areas. The spikes vary in duration and location. Hypsarhythmia varies with the sleep-wake cycle.

●Etiologic evaluation – Determining the etiology of infantile spasms is critical to directing treatment and informing prognosis. •Neuroimaging studies should be performed in all patients with infantile spasms; a magnetic resonance imaging (MRI) is the preferred imaging study because it may detect cerebral malformations, cerebral atrophy, delayed myelination, and other focal lesions not visible on CT scan.

•Further metabolic and genetic testing should be performed if an etiology is not identified after clinical evaluation that includes EEG and MRI.

Lennox-Gastaut syndrome — Some patients with infantile spasms develop a severe form of epilepsy known as Lennox-Gastaut syndrome. This syndrome includes characteristic types of seizures (typical drop attacks and axial tonic seizures) and specific EEG patterns. Children with infantile spasms of unknown etiology are less likely to develop Lennox-Gastaut syndrome compared with children who have a known etiology.

Developmental outcome — Developmental delay occurs in 75 to 85 percent of patients with infantile spasms.

●Monitoring treatment response – Use of overnight inpatient video-EEG to evaluate treatment response is ideal; however, outpatient EEG studies up to 240 minutes can be considered as an alternative. Clinical observation frequently misses subtle spasms, and shorter EEGs are less sensitive for detecting hypsarhythmia.

●Duration of initial therapy – Hormonal therapy is generally given at the maximum dose for 14 days, followed by a gradual taper starting on day 15. Vigabatrin is generally continued for six months in patients who respond to therapy, with continued evaluation for toxicity.

●Relapses – For infants who relapse after termination of initial therapy, a second course of the agent that was effective in obtaining control should be administered.

●Refractory infantile spasms – Lack of a successful response to initial therapy within two weeks should prompt a change in treatment strategy. Alternatives for children who do not respond to hormonal therapy or vigabatrin include:

•Sequential therapy – Our general approach after failure of the first standard treatment (hormonal or vigabatrin) is to switch to the alternative standard treatment.

•Combination therapy – Treatment with both hormonal therapy and vigabatrin may be more effective than hormonal therapy alone.

•Ketogenic diet – A ketogenic diet may control spasms in cases refractory to first-line treatment.

•Surgery – Patients with refractory infantile spasms who have focal brain lesions and no evidence of diffuse brain damage or degenerative or metabolic disease should be evaluated for early epilepsy surgical intervention.

●Outcomes – The overall prognosis for children with infantile spasms is guarded. Mortality ranges from 3 to 30 percent, and, most patients will have impaired neurodevelopmental outcome and/or epilepsy. There is insufficient evidence to conclude that successful treatment of infantile spasms improves the long-term prognosis, although that is suggested by some observational data.

Treatment:

Most infants – For most children with infantile spasms (also known as infantile epileptic spasms syndrome [IESS]), we suggest initial treatment with hormonal therapy using corticotropin injection gel (adrenocorticotropin hormone [ACTH]) or oral glucocorticoids rather than vigabatrin. This recommendation is based upon advantages of hormonal therapy in effectiveness, risk profile, and longer experience compared with vigabatrin.

•Infants with tuberous sclerosis complex – For these infants, vigabatrin is first-line therapy for infantile spasms.

[I would just refer to neurology for management]

•Adverse effects

-Hormonal therapy – Adverse effects are common and include hypertension, irritability, infection, reversible cerebral atrophy, and rarely death due to sepsis. Monitoring should include measurement of blood pressure (baseline and once weekly) and serum glucose, potassium, and sodium levels (baseline and every other week). Infectious contacts should be avoided, and infections should be treated promptly.

-Vigabatrin – Permanent visual field constriction due to retinal toxicity is a potentially severe adverse effect of vigabatrin. Ophthalmologic evaluation and monitoring is recommended.

[soumyafwr]

Infantile Spasms Therapeutics Market Size, Share and Forecast 2031

[amalainse]

"born under a bad sign"

— sukuna ryomen

tags ට yan sukuna, zombie apocalypse au, sukuna typical violence, slight gore (also typical), dubious consent, fingering, petting, dirty talk (are we even surprised), caretaker kink, minor infantilization, wildest backshots known to man, virgin reader

a/n ට baby's first ever fic <3 i've seen a lot of yan sukuna on my dash (1 & 2) and these ficlets/drabbles acted as my main source of inspiration. this wasn't at all how i imagined this to go, but i don't mind doing a second part at all. sukuna's probably occ but to me he's so sickingly sweet to you, and so violent to everyone else.

───⠀౨ৎ you puzzle around the reasons why sukuna would help you, of all people. why he didn't leave you to die. why he goes through the trouble. and then. and then he shows you. (3.6k wc)

the circumstances in which he stumbles upon you are purely accidental. sukuna swings down the hammer, relishes in the sick squelch of bone and sinew giving away and the feel of blood spattering back onto his face in wide arcs and the sight of you going very, very, still underneath him.

you had been so loud, before. screaming and whining and pleading for mercy. you're silent now. he wonders if you even dare to breathe. and that is how he finds it in himself to stop. to pull away. sukuna hasn't seen you yet, and he's curious to know what he's found.

slowly, with trembling, dainty little fingers, one of your hands reaches up to touch the dead mans shoulder. the tiniest of whimpers escapes you, hand spasming but managing enough of your strength to lift up and push the body away.

sukuna lets the hammer clatter noisily to the floor, smirk widening across his face at how you jump, shoulders raised and body tense with obvious fear. he crouches down, blood covered hand wrapping around your ankle and pulling you in to him with one sudden move. you allow yourself to look at his hands, his clothes spattered in blood, and nothing else.

you tremble, head hanging low. sukuna's tongue traces his sharp teeth, content no longer with silence.

"won't you look at me, sweetheart?" he croons, hand smearing blood from your cheek. you tremble and shake some more, ready to burst out of your skin at the juxtaposition of his touch.

but you lift your head. you obey. you must be fighting against every wired instinct right now. the ones that tell you to run. to hide. he doesn't bother hiding the shuddering low moan when he sees you.

"oh, look at you, gorgeous, prettiest little thing i've ever seen" he says, pulling in closer. the blood coating your face does little to hide your shining wide bambi eyes, your full lips, the gentle swoop of your nose. he reaches out behind him, patting around for something to clean your face. "good girl, stay still. just like that"

sukuna's big hand is like a brand against your skin. he cups your chin, turns your head to the side. you make a loud strangled whimper, no doubt having seen what was left of your attacker. sukuna tuts, pulls you back to him, pets at your shoulders and the back of your head until you calm down.

when he turns your head again, you keep your eyes shut.

"wh-what's your. your name?" you say, shakily, eyes darting across his face, pretty brown hands curling and uncurling with anxiety. its clear that you're just looking for something to distract you. it's endearing. you're endearing. sukuna wants to carve out a hole inside his chest and shove you in it.

"sukuna." he says simply, eyes catching on a reflecting light. his thumb trails from the side of your neck now, down to your chest. and the small golden pin pressed into your bloodstained shirt. whistles in surprise. "waseda?"

you nod slowly, reaching for your pin again. sukuna lets you get close enough to grab it and then at the last second, holds it above your head.

his presses the pin back into your palm, and pets at your hair. "bet you would've fetched a pretty penny before all of this huh? sweet little girl like you. what'd you study in waseda, pretty girl?"

"law" you mumble, mouth struggling to form around the word. he barks out a loud laugh at that, petting at your face like one would a nervous kitten. your hands curl into your lap. "do—are you in...are you in school sukuna?"

another loud laugh. he manages to sound mocking and sweet all at once and his voice stuffs your head with cotton. "no, sweet girl. not in school"

"oh." you swallow around nothing again, voice quiet. you don't want to know what he did, before. you aren't sure you'll be able to stomach the answer. silence stretches between the two of you once more, and you know he's waiting for something. "do you have any water?"

sukuna smirks, teeth glinting in the low light. doesn't say anything at all. your mind puzzles over your words, searching for an error. you frown, peering over at him question dancing on your tongue.

he says nothing still. and his hand encloses around yours, pulls it into his lap. he traces over your fingers and up to your wrist, up some more—to your forearm. his other hand reaches for the hammer, still bloody, still wet, as he stands to his feet and pulls you up with him.

you have no choice, but to follow him. you're weak, physically, emotionally, mentally—you never would have been able to survive on your own.

⋅───⊱༺ ♰ ༻⊰───⋅

you wrack your brain, searching for a reason.

before, your family had money. sukuna would have been compensated heavily for his time, for his odd stroke of generosity—no matter the violent steps taken in between. but your family is in america, and you are here, in japan. tears bead at your waterline and you're quick to brush them away but they won't stop falling. they fall faster than your hands can move and you curl into yourself.

sukuna raps his knuckles against the door loudly. waits a moment and then pushes both of you inside. its a bit nicer than what you would assume a man like sukuna—the type of bash a mans head in with you still underneath him—would enjoy. but then it breaches your mind in a moment of painstakingly clarity. you don't know him at all.

"are you going to kill me?" you ask through your tears, shuddering and shaking. maybe sukuna's the sick sort of man you've studied in your textbooks. the kind that like's to draw the violence out, so that it'll hurt more. there's a word for that kind of man.

it's been. it's been days, you think. a week, at most. together, you've encountered a dozen zombies. each time is the same. he pushes you behind him, kills them all quickly and the first time, you threw up. sukuna petted at your hair, crooning softly at you—tells you he'll take care of you. he'll make them go away.

"do you want me to kill you?" sukuna asks instead, smirking. he gestures for you to follow, beckoning you forwards with two fingers.

you shake your head, and then when you realize he can't exactly see, garble out a shaky, "no, b—but why would you help me if i can't. i can't give you anything"

a bathroom is where he's led you to. sukuna drags a small stool over using his foot, plants himself down on it. your mouth parts in surprise when the water turns on, sloshing loudly against the tub.

sukuna hums, tugs you forward—dragging you into his lap. he doesn't answer you, not yet, hands reaching up to tug your shoes off, then your socks. massages his bloodstained hands into your calves, skirting up to your knobby knees and higher still to unbutton your long skirt.

you make a small sound of objection, pushing your legs closed as your breath quickens. "sukuna? what are you, stop please?"

the hand that had been bracing you in his lap reaches down to push your legs apart, easily too easily, and when you try to squirm the hand unbuttoning your skirt hooks around your waist. pulls you back in. one swat against your thigh, underneath the fabric pooling around your waist has you stilling against him.

"just gettin' you clean, pretty girl" he says, petting your sides and your stomach. "gotta take a bath"

"s-sukuna" you hate the way your voice tapers off into a whimper, pushing at his arm again. "i can. i can bathe myself"

there's a snorting sound in your ear, rumbling deep from his chest. one of his hands reaches into your skirt, cups your ass, massages you through your plain cotton panties. and his other hand dances up to your hip, reaches up to hook thick fingers around the bands of your skirt and panties—tugging them down to your knees and then dropping them on the floor.

he makes another amused sound when your hands jump to cover your exposed mound. "you can't do anything by yourself. not if i don't help you"

your mouth pulls into a frown, anger swirling inside you. he says it like he knows you. like its the absolute truth. "that's not true. i can"

sukuna ignores you. like you're a child. reaches up under your shirt to unhook your bra, massaging your small breasts. then again at your spine. pulls your blazer off, then takes special care in buttoning each and every button on your shirt. reaches a hand over to turn the water off, to sprinkle in salts. he's methodical, sure in his movements.

the room fills with the smell of flowers, of almonds and honey. your naked, shivering in his lap from the cold and from the fear strumming along your nerves.

he could break you, but he handles you so gently. you find that your body is as taught as a wire. you wonder how long it'll take for that gentleness to go away. for him to hurt you. to kill you, even though he hasn't said he will.

"isn't that better?" he asks, kneeling beside the tub, washcloth running over your skin. the dirt and sweat and grime washes away from your skin, water turning a murky brown. "i know what you need, sweetheart. i'll take care of you. soft little thing like you, bet you spend your entire life being taken care of."

and then—and then he pulls away. you go to wrap your arms around your middle, thankful that it's over. that that's all he wanted. that your still alive.

your stomach lurches for an entire different reason when you hear the tell-tale sound of a zipper, loud in the quiet room. you hang your head, breathe loudly through your nose and wait. a handful of minutes pass by and then sukuna's hands grab at your waist, lifting you up enough for him to join you.

you turn around, facing his chest. a part of you is surprised that he let you. its becoming apparent to you now that you're going to be doing a lot less of what you want, now. the other part, bigger, pressing, is upset. angry. shameful. why are you giving up so easily? why aren't you fighting back?

the answer hurts more than you'd like to admit. you've never fought back. always gave up so easily. you do what your parents want, act how they think you should. make friends with the people your advisors approve of. sukuna had been so shamefully close to the truth—without anyone calling the shots for you, you're afraid of how little you know yourself.

"i can help" you say softly, grabbing the small washcloth from his hands. really, in all honestly, you just want this to be over faster. don't want him to draw it out anymore. "i can do some things"

sukuna hums, hand reaching out to play with your hair.

he's got a lot of tattoos. and he's big, with huge muscles, hard planes that seem to stretch on for miles. there's nicks, tiny scrapes and cuts and littering of scars everywhere.

"you can do some things," agrees sukuna, once you've finished and the water drains from the tub. he's naked still, and now there water isn't there to hide anything. but he's so large, everywhere, the scent of him filling up your head. "would you like to do something for me, sweet girl?"

you have an inkling of what he wants, and your twist your hands in your lap. you have no choice, even if he phrases it like you do. he could toss you back out there, with the dead roaming the streets, bloodshot and thirsty and eager. so you nod, and climb into his lap, tucking your face into his neck—legs spreading out on either side of his hips when he pushes a hand onto your lower back.

"if you'll be good, i can be good." sukuna says, tracing the knobs on your spine.

you swallow, afraid to ask, but knowing that you must. "you wwon't—you won't let. others?"

"smart girl. good girl, it'll be just me. no other man could take care of you like i could." sukuna's fingers dig into the meat of your thighs, spreads your legs apart to look down at your cunt. you've got ugly hips, like a boy. and you don't shave, and you hope the sparse layer of hair isn't enough to turn him off. you want him to like what he sees. so he. so he can take care of you. your stomach clenches painfully when he presses the flat of his palm on your hipbone.

"you got a boyfriend, pretty girl?"

you shake your head, still tucked into his neck as he continues his caressing and petting. his fingers inch closer to your cunt, rubbing at the outer lips.

sukuna smirks. you can feel it rather than see it. "of course you don't, good girl like you. probably focused on your studies. my little lawyer girl. fuck, sweetheart, you've got such a pretty little cunt. you touch yourself? use your words"

"y-yes—sometimes" you reply, hips jerking as his fingers pet around your clit. you can hear yourself breathing heavier now, and its so shameful, you're dirty—nasty. your parents would be so ashamed of you.

he presses a kiss to the top of your head. it's so so gentle, you think you could cry. "with your fingers, sweet girl?"

you nod against his skin again, but remember that he wants you to talk. to use words. you swallow around a soft sound, trying to close your legs. "yes. but—b-but not my fingers...i tried, and it didn't—it didn't feel, it was okay but..."

god. you hate the way your voice cracks and breaks. how you fumble and trip over words. he must think you stupid now, inept, and your scared you're turning him off, that he might go soft. you clamp your mouth shut, screwing your eyes closed with a tapering whimper as he continues to pet around your pussy.

you're getting wetter, slicking up nicely. sukuna drags your slick to your hole, pets around it. returns back to your clit and rubs faster—at an intensity you would've shied away from if it was just you. a sound escapes you, and you're desperate to choke it down, hips bucking up into his touch.

sukuna swats at your ass, not hard enough to hurt. but a warning. the next sound you make, you don't bother trying to cover it up. his fingers flick at your clit in reward, and then his middle finger begins to press inside.

"there we go, good girl, relax for me, fuck, you're so tight" he sounds like he's putting his cock in your...in your cunt. and not, not his fingers. you whimper, nails pricking into his skin when his thumb returns to your clit. he pulls out, presses back in, other hand guiding your hips down into a slow rhythm. "that feel good?"

"yyeah" you sigh, making another high noise when a second finger presses in next to the first. he's speeding up now, and the sound of slick spurting out of your cunt, his fingers slamming up into your hole, stretching you out and its so—its so dirty but he isn't stopping, and had your nails dig into the meat of his shoulders. he's reminded of a cat sticking its nails into its owner, and thats you, you're his little kitten, gushing slick all over his hands, making little uhuhuh noises, endless whimpers and gasps of his name. "su-su'kuna, 'kuna! ohhh, uh, uh—'kuna"

sukuna throws his head back, cock so hard its throbbing. like he could cum. like he could cum and all he's got is two fingers inside your weeping cunny. if you sound like this now, if you're arching like this now, hips bucking up and legs kicking like this now—

"fuck baby, thereee you go" he goads, thumb reaching up to massage at your clit. the coil in your lower belly tightens up, faster and faster and sweat burns down your neck and you can tell you're about to come and you try to—you try to get the words out, hand that was previously clawing at his skin reaching down to try and push his hand away. but sukuna's stronger than you, not stopping, grunting out in your ear "can't wait to get inside this cunt. gonna fuck her so good, gonna give my sweet girl what she needs, shit, baby, listen to you, sound so pretty—you're such a good girl. gonna cream around me so good. go ahead and cum pretty, let go, i'll take care of it"

that feeling draws up, tighter and tighter and to fight back a scream, you bite down on his neck, panting wetly against his skin. your legs kick out, squirming wildly in his lap and your orgasms crashes into you like a freight train.

sukuna—he. he keeps his promise. takes care of it, talks you through it, fingers still pumping inside and stretching you out. presses sweet kisses to the side of your face, doesn't even seem to feel your teeth digging in, free hand running up and down your spine. laughs, whenever you seem to come back to it.

his hand reaches up, pats your ass softly. "on your stomach baby, good girl"

it would have been harder, you think, if you hadn't already cum. but you're pliant, going easily to your stomach. you can feel his hands, hot like firey brands, pulling you up to your knees, gripping tightly onto your hips. he cants his cock up against your pussy, swipes it through your slick before reaching down to guide it inside.

your mouth parts on a loud moan, eyes rolling into the back of your head. he's so much bigger than his fingers, wide and girthy—filling you up so well. he pulls out, pushes in a little more, repeats the process until his balls push up against your ass with a soft smack that has you both groaning out.

his hands fall back to your hips, pulling all the way out before slamming back in. you let out a loud yelp, almost pained, sensitive from just cumming and he's thrusting into you with short, hard jerks of his hips, cock hitting your sweet spot so well, breaths coming out of you in aborted little gasps. you fall forwards into the pillows, moaning louder now and sukuna doesn't slow down—but he speeds up, goes harder, grunting softly underneath your whiny and wet noises.

"ffffuck, fuck, baby, yeah. good fucking girl. knew this'd be the tightest little cunt. squeezin me so tight, pretty girl" pours the dirty words from his mouth as his balls smack loudly against your ass. your cunt squelches, so wet from your orgasm and getting wetter still. your hands fly to his arms, whining, pushing blindly at him. its too much, too fast—you can't take it, and you whine again, hands clawing at the sheets trying to—"no, no, fuck. don't run from it baby. c'mon you can take it, i know my good girl can take it"

you can't speak, so you shake your head wildly, jerking forwards hard enough that his cock slips out and that makes you moan like... like a whore, turning on your side to catch your breath. but its only for a second, before sukuna's back, guiding you onto your front with a soft cooing noise—slipping back inside.

its a different angle now, with his arm around your waist, keeping your ass nice and pert against his cock as he drills into your weepy cunt. dirty talk spews from his mouth, telling you to take it, telling you how good you are, how tight your cunny is clamping around his cock. calls you a whore, a slut, and you whine loudly at that, hands spasming in the sheets as you shake your head wildly.

"i-i'm not," you protest, pushing your ass back, "not a slut, 'kuna, not—i'm not, please, pleasepleasepleaseples—"

sukuna laughs, sounding dark and sarcastic. "no, baby, i'm sorry—fuck, you're not a slut, just fffuck, you're just so good for me aren't you? sweet girl, taking it so well, pussy's so good baby, i'll keep you forever. keep you right here on my cock, mm. wanted to be gentle for my sweet girl, i'll treat her right next time—"

his thrusts send you up the bed, headboard knocking against the wall, and you can feel his face shove into the sheets next to your head as he speeds up. he's close to cumming, he tells you as his fingers intertwine with yours. he squeezes your hand tight, grunting lowly in your ear before pulling out so fast your body crumples to the bed like dead weight. he jerks his cock quickly, spurting cum over your ass and lower thighs.

you cough, swallow around your slightly hoarse throat. "they...su-'kuna, what if they...heard? and they come?"

sukuna's hands caresses your flank, every inch of bare skin he can reach. "didn't i tell you i'd take care of it sweetheart?"

you think you manage to nod, fighting against your eyes slipping shut. and you think, you think sukuna laughs again, promises again that he's not letting you go. and your heart clenches when you realize what it had been, the reason he had helped you in the first place.

and it makes you feel gross, makes you feel used. like a whore. and you fall into sleep. and the last thought on your mind is, he'll take care of it.

[claudehenrion]

Je vous souhaite une très joyeuse mort, en pleine fraternité macronienne…

Je n'ai jamais pu trouver d'explication à cette aberration : les mauvaises idées semblent être plus souvent prises en compte et mises en œuvre que les bonnes. Et je crois remarquer une accélération dans le processus actuellement en cours qui veut que de plus en plus d'idées de plus en plus mauvaises fleurissent (?) de plus en plus vite et de plus en plus souvent ! A la veille du Vendredi Saint, quel beau sujet que le dévoiement de notre mort, qui se met en place, dans une débauche de fausses informations, partielles ici, et partisanes, là, mais mensongères, toutes.

Mais pour une fois que les “bouffe-curés” et les “tue-dieu” admettent enfin que la mort peut être vaincue, comme les chrétiens le leur répètent depuis 20 siècles… on ne va pas mégoter notre plaisir, en cette Semaine Sainte où s'ouvre la phase finale de la mise en œuvre de ce caprice macronien, qui sera lancé sans qu'aient été évaluées –même un tout petit peu– les suites à long terme de cette initiative qui a toutes les chances de produire, au mieux, quelques avantages… et au pire des séries de drames dont l'humanité aurait préféré faire l'économie. Décidément, depuis le faux “vaccin” du covid, prendre des décisions mortifères est devenu un “marqueur” du progressisme, cette maladie infantile du modernisme !

Prenons la triple anti-idée terrifiante, qui a pourtant le vent en poupe, de l'invention d'un “droit à l'assassinat légal, au suicide aidé et à la mort par délégation’’. Ces trois modalités d'une même chose, la mort, ont inspiré des raz-de-marée de lavage de cerveau, de viol des consciences, de réinvention du sens des mots, et de détournement de l'attention de tous les vrais problèmes, à la macronie moribonde (NB : méfiez-vous des ultimes spasmes d'un animal blessé : ils peuvent être dangereux et faire beaucoup de dégâts !). Manque de bol, une fois encore, ça a marché, et bien des gens se sont laissés abuser, adoptant les expressions –toutes mensongères– qui ébranle,t l'intelligence.

Le nombre de paraboles, hyperboles, métaphores, fables, mensonges, bobards, et barbarismes qui ont été déversés sur nous par la Presse et la Gauche est très au delà de tout ce qui se pratique normalement. C'est simple : on ne sait plus du tout de quoi ils parlent ni ce à quoi ils pensent (car des milieux “généralement bien informés” m'assurent qu'il en resterait quelques uns qui pensent… Je ne les ai pas trouvés). Et s'il est toujours vrai que “les mots tuent”, c'est le moment où jamais : après, il sera trop tard ! Car depuis que le monde est monde, tuer, directement ou par délégation, un vieillard, un grand malade ou un embryon pas encore né mais parfaitement viable, ça avait un nom : un assassinat.

Mais dans un grand souffle libérateur, la hollando-macronie a tripoté les lettres et les syllabes, jusqu'à inventer les concepts affreux de “mort dans la dignité”, de “preuve de fraternité” (il y a des coups de pied… “occultes”, qui se perdent !), de “liberté de mourir” (et puis quoi, encore !), et de tant d'autres insanités. Nos irresponsables ont été jusqu'à inventer une soi-disant “aide à mourir”… pour le seul moment où aucune aide n'est possible ! Dieu, pour les uns, un “grand ordonnateur” pour d'autres, le “destin” pour d'autres encore, et… “rien” pour les plus pauvres d'esprit… fixe ou fixent le moment où la machine s'arrête, et personne ne peut avoir le moindre effet sur cette décision… si tant est qu'il y en ait une : on a beau bricoler l'horloge du temps, avancer l'échéance de quelques pouillèmes d'éternité, prétendre que “Moâ, ce petit dieu raté, je suis maître de mon corps” ou, comme d'aucuns, se proclamer (tout seul) “le maître des horloges”... c'est baratin & Co.

Car la seule chose qui ne fait pas de doute, c'est que nulle “force de l'ordre”, nul “agent de l'Etat”, nul GIGN, nulle “CRS 8”, nul dossier et nulle procédure “CERFA” ne pourra dire que la date de péremption est dépassée, qu'on a triché en respirant 3 fois de plus qu'indiqué sur la notice d'emploi, ou qu'un tel n'est plus qu'un nom à “zapper”, un sac noir à jeter au tri sélectif–(poubelle jaune) : la vision de la mort que peut avoir un élu macronien (je veux dire : “nul mais élu !”) est rien moins que désespérante… C'est à se demander avec quelle partie de leur corps ces trucs-là pensent ! Pour ces normateurs de l'innormable, “mourir dans la dignité” se résume à passer l'arme à gauche (NDLR : cette expression ancienne est une preuve éclatante que les mots ont un sens !) en se conformant scrupuleusement à un des 2 ou 3 protocoles prévus par une loi qui parle d'autre chose que du sujet de son titre ! Leur mort dans la dignité n'est qu'une mort dans les normes administratives.

Soulagez la souffrance, comme vous devriez apprendre à le faire, bande de Jocrisses, mais arrêtez de prétendre que vous pourriez avoir la plus petite influence sur un changement de nature de la mort : c'est la seule cérémonie à laquelle nous ne pourrons pas nous soustraire, et dans laquelle nous sommes certains de “ne pas avoir la main’‘ ! A l'opposé de leurs fatras fumeux, ’'mourir dans la dignité”, ce n'est pas “raccourcir ce qui ne doit pas l'être”, mais c'est –et ce n'est, ce ne peut être que– donner à chacun de pouvoir s'architecturer intérieurement, de résister aux sirènes trompeuses de l'époque, de trouver des contre-poids à la sous-culture du superficiel, de l'instant, de la trouille permanente, et de l'infantilisation, qui nous maintient dans une ignorance doucereuse et qui tue en nous tout sens moral, toute force spirituelle, toute résistance intellectuelle, la colonne vertébrale et le courage.

Bon ! Je sais bien que ces tentatives désespérées de rater son but affiché doivent tout à une pression morbide qui est dite “sociétale”, comme on dit dans le jargon gauchiste pour désigner l'amnésie volontaire… ce qui met la trop changeante “opinion publique” du côté des promoteurs de la vraie misère humaine : la plupart de nos contemporains ont, avec l'inévitable, un rapport fuyant, de déni et de rejet. C'est une triste évidence qui explique bien des malheurs que notre monde se fabrique en croyant résoudre l'insoluble… et qui n'existaient pas, lorsque le “métier d'homme” impliquait force, âme, courage et (j'ose !), la vie… jusqu'à en mourir.

Car mourir et vivre ne sont pas 2 choses séparées comme on nous le fait croire dans notre univers en voie de putréfaction en inutiles marches blanches, mais une seule et même chose, une seule et même aventure, un seul et même achèvement. Un éventuel “droit à mourir dans la dignité”, ce bobard fou pour politicards trop jeunes pour savoir de quoi ils parlent, ne saurait être ramené à un étalage de sensiblerie étalée complaisamment, comme sur les réseaux sociaux ! Partis comme nous le sommes… nous serons bientôt projetés dans un univers du type “Soleil vert”, ce Soylent Green, livre ou film sur la mort assistée, de Harry Harrison (1966)…  Encore un effort, Monsieur le bourreau…

Je veux bien, à la rigueur, qu'on me parle de modifier la définition de la mort : je suis poli, et j'écouterai… en pensant à autre chose. Mais alors, s'il vous plaît, messieurs les irresponsables, que ce soit avec Montaigne, avec Bossuet, voire avec Platon, Epicure, et même Spinoza… ou –comme le faisait Mitterrand– avec un Jean Guiton. Mais je vous en supplie, qu'on m'épargne le cornet acoustique miniaturisé pour pensée-clonée de ces fausses vedettes du petit écran qui sont les nouveaux “maîtres-à-ne-pas-penser” érigés au rang d'oracles par notre époque qui ne peut que devenir lamentable à leur contact (et sur ça, on est bien parti !).

Une authentique “dignité” consisterait à être de vrais humains et à le rester jusqu'au bout, souffrance ou pas. Si vous saviez dans quelle harmonie sont morts tous les êtres chers qui m'ont quitté… J'aime me souvenir d'eux, être fier d'eux jusqu'au bout, les admirer, et ne pas avoir le remords de leur avoir volé, au nom de la sensiblerie fadasse et pleurnicheuse qui a envahi nos jours et obscurci notre jugement, LEUR MOMENT absolu, le seul… le ''bilan'' de leur vie.

En lisant toutes les insanités, tous les mensonges et toutes contre-vérités qui encombrent, polluent et salissent ce débat, il m'est venu une idée que j'aimerais partager, amis-lecteurs, “pour ce quelle est’' : sans doute fausse, mais méritant peut-être qu'on y pense deux secondes : après bientôt deux quinquennats ratés, un Macron-superman, ivre de ce qu'il croit qu'il est, trouve génial de transformer notre société et tous ses membres, en clones de ce qu'il imagine être (sous-entendu : un être supérieur, au niveau des dieux, et (osons le dire, avec modestie) Dieu lui-même). Pour ce faire, il déforme les mots, les idées, l'histoire, la culture, les systèmes de pensée et de référence… et crée un univers où plus rien ne peut exister, hors de son propre (?) néant : en chamboulant tout, n'importe comment pourvu que ça soit vite, et en mettant tout ’'cul par dessus-tête”, il fait de nous des zombies incapables de résister à toutes ses folies prétendues “sociétales”.

Nous découvrons peu à peu que nous devenons non pas ce qu'il s'imagine être, mais ce qu'il est : un grand vide, un cyborg en creux, superficiel, insignifiant, sans colonne vertébrale, changeant, flou, sans bon sens autre qu'insensé, fuyant le réel, inconsistant, sans passé –donc sans présent et sans futur, et hésitant, dans un désert sidéral, entre une non-pensée et une anti-pensée. Le seul ennui, c'est que le train est lancé et que nous avons laissé faire, sans rien dire –au contraire, pour certains– ce grand pas vers notre destruction, en tant qu'humanité et que civilisation. Dis, Monsieur, comment ça s'arrête, une catastrophe en marche ?

H-Cl.

[star--nymph]

Hello, everyone. My friend asked me to spread her cousin's go fund me around to help her son, Ezra. Please consider donating to help her with his surgery and with paying rent. Any little bit counts and if not, I implore you to spread this around as any attention can help!

Hello world, my name is Raquel. I’m a 25 year old single mother of two beautiful boys. My youngest son has been diagnosed with infantile spasms/ epilepsy when he was 4months old. The last two almost three years have been a battle for my little warrior. We’ve tried countless medications that have no affect on my son Ezra. In the next couple of weeks my son will be undergoing brain surgery. The surgeons be clipping a part of my sons brain in hope of reducing his seizure giving him a chance to possibly forming his personality, talking, and walking. Due to all of his appt, the surgery, and his long recovery I’ll be missing a lot of work and struggling to make ends meet. I truly appreciate any help that is given and that you keep my son in your prays.

[my-autism-adhd-blog]

Hi everyone,

I was looking into the possibility of autism being connected to epilepsy since I have both. And it turns out that there is a connection. According to one article:

Comorbidity of epilepsy and autism is frequent; approximately 30% of children with autism have epilepsy and vice versa. The high rate of comorbidity is thought to be caused by genetic and microstructural brain differences. Both conditions predispose individuals to abnormalities in neural connectivity, although the exact pathophysiology of both conditions remains unknown. There is evidence for epigenetic factors playing a role in some situations. For example, children who have infantile spasms during critical windows of social and language development (6-18 months) are more likely to later develop autism. There are also syndromes in which a known single gene mutation confers a high risk for both epilepsy and autism (ie, fragile X syndrome).

I found this very interesting. I’ll leave the article below so anyone can read.

Epilepsy

Autism

[ayin-me-yesh]

Something I see online that's frustrating to me is you'll get people telling the vegan activists who promote veganism as a universal ideal that there are disabled people who can't have a vegan diet, but then a lot of the people who point this out don't seem to know what conditions actually cause that. And then you end up having arguments about that so I want to actually point out a few examples

I think the number one example where there's no way to safely, healthfully avoid having to consume animal products is haemodialysis for kidney failure. People on dialysis need more protein than other people because they lose protein and blood cells during the dialysis process, and they are required to have a low potassium diet because their kidneys can't filter potassium. This means legumes and soy aren't viable alternatives. [x] "Renal dietitians encourage most people on haemodialysis to eat high-quality protein because it produces less waste for removal during dialysis. High-quality protein comes from meat, poultry, fish, and eggs." [x] If you can't meet your protein needs with these foods for whatever reason, you'll be prescribed whey protein powder, which is made from dairy. [x]

Ketogenic diets are also high in animal proteins. They're innately low carb and high in fat, which means legumes and other meat alternatives aren't a great fit. "The ketogenic diet can boost insulin sensitivity and cause fat loss, leading to significant health benefits for people with type 2 diabetes or prediabetes." [x] PCOS, a common condition effecting about 10% of people who menstruate, is also often treated with a low carb, high protein diet because it involves insulin resistance. [x]

Ketogenic diets may also be recommended to treat seizures in epilepsy. [x] It is most frequently used for focal seizures in children, infantile spasms, Rett syndrome, tuberous sclerosis complex, Dravet syndrome, Doose syndrome, and GLUT-1 deficiency. In these conditions, ketogenic diets can reduce or even eliminate seizures.

People with food allergies can find it difficult to afford safe and healthy food in general. [x] The inability to rely on cheap, plant-based proteins like canned beans or dried lentils can be a general hardship, especially when disabilities themselves can limit job opportunities or the capacity to work.

Intestinal disorders are another factor that can make vegan diets difficult. Foods high in insoluble fibre, like beans and other legumes, as well as nuts and seeds, can cause Crohn's flare ups in some people. [x] Seeds, nuts, and legumes can also be trigger foods for people with ulcerative colitis. [x] IBD flare ups are not like a run-of-the-mill case of intestinal discomfort. They can land people in the hospital and require major surgery. [x]

For allergies, the main factor that can make a vegan diet difficult isn't allergy to specific vegetables, but to specific plant proteins. Someone who is allergic to soy, peanuts, or other legumes will have more limited options for meeting their daily protein requirements on a vegan diet. People with allergies to a broad spectrum of legumes may not have any reasonable substitution options. Substitutions can also increase the price point and make a vegan diet too expensive for people in poverty who also have allergies. Poor people with food allergies may find it difficult in general to afford a safe and healthy diet. [x]

For some people, including some disabled people, a vegan diet may in fact be ideal. Vegan diets can certainly be part of a healthy diet when trying to reduce bad cholesterol [x], treat high blood pressure [x], or treat earlier stages of kidney disease. [x] And while insulin resistance may be best treated with a ketogenic diet in some people, others do seem to benefit from a plant-based diet instead. [x] A person's diabetes specialist and trained dietitians can help them figure out which is best for them, potentially based on other factors like whether or not they have high blood pressure or bad cholesterol, or whether their diabetes risks are linked to PCOS or other known metabolic conditions.

Achieving sustainable food production and equal access to a safe, nutritious, well-balanced diet is fundamental to us all. But there's simply no one-size-fits-all ideal human diet, and that's something everyone needs to take into account.

[malusrecord]

~"Hedwyn, what can I do?" She'd heard of this, she knew it was a fate that befell all exiles to the Downside, but to see it happening to him was unacceptable. "I'm here for you Hedwyn, I'm here!" She's gingerly cradling his head in her hands, afraid she'll hurt him more. (because I love that hc you posted earlier about his horns aaaaa)

All he can feel is heat. Heat. Heat. Heat. An unbearable heat that DRIVES HEDWYN TO HIS KNEES as it surges through him, with the maddening core of it boiling at the very center of his head as Hedwyn's already exhausted body spasms underneath the pain. He can feel his mouth dropping open in a silent scream---and stars, oh stars, he wants to scream but they would be jagged, pitiable howls that require more AIR THAN HIS LUNGS COULD EVER HOPE TO HOLD---and so all he can manage is gasps that get weaker by the breath.

"I...I..I..'m...ha......!" Hedwyn's words snag sharply in his throat as the heat radiating through him suddenly surges as it THRUSTS ITS WAY OUTWARDS and actually intensifies as it goes rather than relenting. Now he does scream; one hard wail as he can feel something---horns, the curse born by all who were cast to the Downside---sprouting out of his head with a rush of blood that mixes into his hair before freely running down his face. He's clawing at his head and face now; frantic and feverish, heedless of the blood, heedless of the new and sudden pain as his grasping, scrabbling fingers are PRICKED BY THE TIPS OF THE STILL INFANTILE HORNS that would only get longer and larger as the years ticked by. If he could just rip them out and have done with it then, then, then----!

A voice then---equally frantic but not his own---spears through Hedwyn's screaming, red soaked senses. Someone was calling to him, someone was trying to grab hold of him....someone....!

"...Gh...!" The exile sways and his hands drop suddenly; blood soaked fingers now being caught by someone else's' but he couldn't bear to open his eyes, couldn't bear anything more, and yet his body SHUDDERS WITH A KIND OF GRATEFULNESS as he dimly, dimly, dimly, oh so dimly, feels far softer hands than his own cradling his sweat and blood-soaked face. Someone was....someone... "R...Rh...." He can't say it---Friend, Ligaratus, Miche...!---but he tries, oh how he tries. "Mi.....ch...e..." Now the hands catch and hold him tightly as Hedwyn drops fully, pressing his shivering, dead weight against his fellow exile's kneeling form as her words---partially audible and pulling him towards an end to the suffering he was currently experiencing---grasp at him in their own way. I'm here for you. I'm here for you. I'm here for you. I'M HERE FOR YOU, NOW AND ALWAYS.

[soumyafwr]

Infantile Spasms Therapeutics Market Size, Share and Forecast 2031

[theblogs2024]

How To Use Vigabatrin Powder: A Move-by-Move Guidebook

Vigabatrin powder is a medication applied to treat epilepsy and infantile spasms. Proper utilization of the medication is very important to make certain its efficiency and to minimize opportunity Unwanted effects. This article presents an in depth, step-by-phase guide on how to use vigabatrin powder effectively.

What is Vigabatrin Powder? Vigabatrin powder is definitely an antiepileptic drug designed to regulate seizures by growing the amounts of gamma-aminobutyric acid (GABA) while in the Mind. This neurotransmitter helps you to tranquil nerve action, therefore minimizing the occurrence of seizures.

Step-by-Phase Guidebook on Utilizing Vigabatrin Powder 1. Speak to your Health care Service provider Before beginning vigabatrin powder, it is vital to consult with your healthcare service provider. They are going to establish the suitable dosage depending on your age, bodyweight, and health care condition. Frequent follow-up appointments are vital to watch your response on the medication and adjust the dosage if required.

2. Getting ready the Dose Vigabatrin powder ought to be well prepared in accordance with the Directions supplied by your healthcare supplier or even the medication guideline. Below’s a standard process:

Evaluate the Powder: Make use of the measuring gadget provided With all the medication to ensure the proper dose. Do not use residence spoons because they might not be accurate. Mix with Drinking water: Dissolve the measured powder in a selected degree of drinking water as instructed. Stir the mixture right until the powder is completely dissolved. 3. Administration Oral Ingestion: The mixture must be taken orally. You usually takes it with or with no food items, nevertheless it is important for being consistent within your strategy. Timing: Go ahead and take medication simultaneously each day to keep up an excellent stage in the bloodstream. This regularity aids maximize the effectiveness from the medication. four. Storage Place Temperature: Retail store the powder and also the organized mixture at space temperature, faraway from direct gentle and dampness. Keep Outside of Attain: Make sure the medication is out of reach of kids and Animals to stop accidental ingestion. Crucial Guidelines for Utilizing Vigabatrin Powder Adhere to Dosage Guidance Under no circumstances change your dosage without the need of consulting your Health care company. Overdosing or underdosing can decrease the efficiency on the treatment method and raise the chance of Unwanted side effects.

Keep an eye on for Side Effects Typical side effects involve exhaustion, fat get, and possible vision adjustments. In case you see any intense Unwanted effects or strange signs, Get hold of your Health care company straight away.

Regular Eye Exams Vigabatrin can cause eyesight challenges, together with peripheral vision decline. It is actually important to acquire common eye examinations right before and during procedure to observe any alterations in eyesight.

Drug Interactions Advise your healthcare service provider about all other drugs you happen to be using, such as in excess of-the-counter medicine and supplements. Vigabatrin can communicate with other drugs, which can impact its efficacy or enhance the possibility of Uncomfortable side effects.

Pregnancy and Breastfeeding When you are pregnant, intending to develop into pregnant, or breastfeeding, talk about together with your Health care provider before starting vigabatrin. The medication could possibly have hazards for the fetus or toddler.

Conclusion Applying vigabatrin powder effectively is vital for taking care of epilepsy and infantile spasms efficiently. By following your healthcare supplier’s Guidance, getting ready and administering the medication properly, and adhering to security safety measures, you'll be able to enhance the advantages of vigabatrin and lessen likely threats. Typical consultations using your healthcare service provider and monitoring for Negative effects will help be certain the absolute best end result from a cure.

Learn more info. check out here: vigabatrin powder

[medicinehealth360]

Infantile Fever, Spasms, & Seizures  Emergency

[daicelpharmastandard]

Tetracosactide: Unveiling Therapeutic Potential in Adrenal Insufficiency

Tetracosactide is a synthetic analog of adrenocorticotropic hormone (ACTH), which is produced naturally by the pituitary gland. This medication is primarily used for its effects on the adrenal glands and is commonly prescribed in certain medical conditions. Here are some of the key uses of tetracosactide:

Adrenal Insufficiency:

Tetracosactide is often prescribed for individuals with adrenal insufficiency, a condition where the adrenal glands do not produce sufficient amounts of cortisol, a vital hormone involved in various physiological processes. By mimicking the action of ACTH, tetracosactide stimulates the adrenal glands to produce cortisol, helping to regulate metabolism, immune response, and stress reactions.

Diagnostic Testing:

Tetracosactide is sometimes used in diagnostic tests to assess adrenal gland function. The synthetic hormone can be administered, and blood cortisol levels are measured before and after the injection. This helps healthcare professionals evaluate the responsiveness of the adrenal glands and diagnose conditions related to adrenal insufficiency or dysfunction.

Nephrotic Syndrome:

In some cases of nephrotic syndrome, a kidney disorder characterized by excessive protein in the urine, tetracosactide may be prescribed. It is believed to have anti-inflammatory and immunomodulatory effects that can help manage the symptoms associated with this condition.

Multiple Sclerosis:

Tetracosactide has been investigated for its potential use in the treatment of multiple sclerosis (MS). Some studies suggest that it may have immunomodulatory effects that could be beneficial in managing certain aspects of the disease. However, further research is needed to establish its efficacy and safety in this context.

Seizures in Infants:

In some cases of infantile spasms, a rare and severe form of epilepsy that typically begins in infancy, tetracosactide may be considered as part of the treatment plan. Its use in this context is often guided by a healthcare professional and is part of a comprehensive approach to managing the condition.

It's important to note that the use of tetracosactide should be under the supervision of a qualified healthcare professional. The dosage and duration of treatment can vary based on the specific medical condition being addressed, and the medication may have side effects that need to be monitored.

As with any medication, patients should inform their healthcare provider about their medical history, existing conditions, and any other medications they may be taking to ensure the safe and effective use of tetracosactide. Regular follow-up appointments and ongoing communication with the healthcare team are essential for monitoring the patient's response to the medication and adjusting the treatment plan as needed.

[sudheervanguri]

PGIMER Hiring Pharmacology/ Biotechnology / Life Sciences Candidates for JRF Embark on a rewarding career journey with PGIMER (Postgraduate Institute of Medical Education & Research), an esteemed institution inviting applications for the position of Junior Research Fellow (JRF) in the Department of Pharmacology. This opportunity is part of a DST SERB funded project aimed at evaluating the effect of IGF-1 analogue and NMDAR antagonist in a rat model of infantile spasm. Join us at PGIMER, Chandigarh, and contribute to groundbreaking research under the guidance of Dr. Lekha Saha, Professor, Department of Pharmacology. About PGIMER: Company Name: Postgraduate Institute of Medical Education & Research Location: Chandigarh, India Overview: PGIMER, a renowned medical research institution, stands at the forefront of medical education and healthcare. Our commitment to excellence, research, and innovation has made us a leading choice for individuals passionate about advancing their careers in the medical field. PGIMER Vacancies: Junior Research Fellow (JRF) Number of Positions: 01 Stipend/Consolidated Salary: Rs. 31,000/- per month (plus HRA as per rule) General Information: Essential Qualification: First-class Postgraduate in Pharmacology/Biotechnology/Life Sciences. Age Limit: Not exceeding 35 years. Duration: Initially up to 1 year, extendable up to completion of the project. Desirable: Research experience in molecular-based techniques and animal handling. Job Description: As a Junior Research Fellow at PGIMER, you will be involved in a DST funded project focusing on the evaluation of IGF-1 analogue and NMDAR antagonist in a rat model of infantile spasm. The role includes molecular-based techniques, animal handling, and contributing to reducing excitotoxicity. [caption id="attachment_61010" align="aligncenter" width="1200"] PGIMER Hiring JRF in Pharmacology/Biotech/Life Sciences[/caption] How to Apply: Interested candidates can apply through the provided application form. Submit hard copies of the application form along with relevant documents to Room no. 4034, 4th floor, Department of Pharmacology, Research block B, PGIMER, Chandigarh. Alternatively, email the soft copy of the application form and required documents to Pharmalab4034@gmail.com by 5:00 PM till 31 January 2024. Note: A No Objection Certificate from the current employer is required. No TA/DA will be paid to the candidate. Shortlisted candidates will be called for an interview on 7 February 2024. If the number of candidates is high, a written test may be conducted on the interview date.