#guo xiaodong

[cinemacentral666]

24 City (2008) & Cry Me a River (2008)

Movies #1,065 & 1,066 • Part of My JIA ZHANGKE Director Focus

JZ’s dual offerings for 2008: a faux-(or not so faux?)-documentary (24 City) and a short film, Cry Me a River (featuring long-time regulars Wang Hongwei and Zhao Tao), feel like minor works in the grand scheme of things. 24 is an interesting setup and potentially his most boundary pushing insofar as bleeding realism into the realm of narrative fiction is concerned. But I was a bit bored by both.

SCORE: ⭐️⭐️⭐️⭐️⭐️⭐️ (for both)

[hiddenonigiri]

watching amidst a snowstorm of love and the funniest thing to me is that like... as much as yin guo loves lin yiyang...

meng xiaodong is even more in love with him

[perfectlyincandescentlyhappy]

Request for Fanfic (Amidst a Snowstorm of Love)

guys can someone please write a soft fan fic about Meng Xiaodong and OC where she fell first and has been pining over him for years and then he fell harder..... And can it be soft like Yin Guo and Lin Yiyang.....and with maybe one or two intense scenes of confession/realisation.

[twilightronin]

Happy Birthday Andy On!

[movs4up-blog]

True Legend

Su Qi-Er, a wealthy man living during the Qing Dynasty who loses his fortune and reputation as a result of a conspiracy against him. After being forced out onto the streets, Su dedicates his life to martial arts and reemerges as a patriotic hero known as the “King of Beggars.”

[cfensi]

Air date update, February 2019

Air date update, February 2019

Airing since Jan 30th:

My Father and Daddy 我的亲爹和后爸 starring Zhang Yi, Zhang Guoli and Li Jianyi

A World Without Fraud 天下无诈 starring Guo Xiaodong, Xu Yue

Yanshifan: New Youth 艳势番之新青年 – Feb 6 Starring: Huang Zitao, Yi Yangqianxi, Hu Bingqing Details: 60 eps, daily drama on Dragon TV / Beijing TV A forward-thinking noble and a commoner band together to save their country. (Extended)

(more…)

[us-china]

3rd Hainan Island Int'l Film Festival concludes in Sanya

3rd Hainan Island Int’l Film Festival concludes in Sanya

Actress Tong Liya (L) and actor Guo Xiaodong Xinhua | 30-Dec-2020 Actress Tong Liya (L) and actor Guo Xiaodong pose during the closing ceremony for the 3rd Hainan Island International Film Festival (HIIFF) in Sanya, south China’s Hainan Province. (Xinhua/Guo Cheng)

[kartikdutt]

MERCEDES BENZ "Intelligence by your side" from Jonathan Gurvit on Vimeo.

* Director's cut

Director: Jonathan Gurvit Director Producer: Ruben Goots (Hamlet.tv) DOP: Carlos Ritter Editor: Matt Osborne Music: Massive Music Tokyo Production: Gwantsi EP: William Huen EP Assistant: Dora Su / David Liu / Zuyue Li / Cici Zhang Producer: Xiaodong Huang / Yunyuan Xue Production Assistant: Jiaxing Liu / Xu Tao Casting: Lu Ye 1st AD: Jiji 1st AD (2nd unit): Tik Liu Art Director: Zheru Ye Prop Master: Jun Wang / Suchun Zhang / Zhengguang Fu / Xueyang Fu Gaffer: Weimin Tan DOP(2nd Unit): Zhi 2nd AC: Ming Liu / Yang Yan / Chenxu Liu 1st AC: Elephant 1st AC(2nd unit): Weiguo Yu Remote Head: Xuechun Jiang / Yao Shen Stylist: Yu Zou / Yuqing Chen / Rong Ni / Jiangkui Zhao Drone Pilot: Enliang Guo / Gongcheng Yang DIT: Meishui Song / Zhiman He Script Supervisor: Yingzi Precision Driver: Xue Jin

VFX Company: LAPOSTA EP: Pablo Tufaro Producer: Celeste de Dios Vfx suervisor and Cg Head: Nicolas Cantarelli VFX Head: Damian Brillantino and Federico Quiros. 3D Modeler: Pablo Verettoni, Carlos Andreoni. 3D animators: Iga moto, Roly, Nicolas Broner, Hernan Caratoli, Nicolas Cantarelli. 3D lighting and Render: Facundo Lavenia, Alejandro Libman, Gonzalo Canepa. VFX simulation: Martin Peralta. Compositors: Damian Brillantino, Federico Quiros, Cristian Bopp, Diego Dzisiuk. Color Grading: Alejandro Armaleo.

Agency: Ogilvy & Mather Beijing Managing Partner: Autumn Guo Vice President：Tommie Yin Account Director: Isis Liu Associate Account Director: Shanshan Du

Client: Mercedes Benz China Head of Marketing: Freda Wang Senior Manager,Marketing Communication: Ning You Creative Management: Yao Zhao Creative Management: Yihan Jin

[paintingarta]

Five Gigantic Influences Of Famous Chinese Contemporary Artists | Famous Chinese Contemporary Artists

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[vidovicart]

Colorful Ceramics Accented by Gravity-Defying Drips

Photo courtesy of Bian Xiaodong

Rain falls through the air in smooth curvaceous orbs, instantaneously splitting as it splatters to the ground. Chinese artist Bian Xiaodong’s glossy ceramics resemble these falling droplets, however their inverted forms drip upwards rather than down. The artist crafts his gravity-defying artworks from kaolin clay derived from Jingdezhen —a part of east China’s Jiangxi Province known for its history of crafting porcelain.

After adding the clay to silicone moulds, Bian turns the pieces upside down and lets the natural flow of the clay create a unique shape. In the high-temperature firing process, this ultra-thin clay body further morphs into different forms. Once his ceramics are formed, the artist paints them, using an array of colorful pigments including metallic grey and sunflower yellow. “My work attempts to discover the special texture of ceramic materials, and the beauty that is brought to me by the natural forces,” he explains to Colossal. To view more of Bian’s raindrop-like artworks, visit the China Design Centre’s online gallery.

Photo courtesy of Bian Xiaodong

China Design Centre, photo by Phoebe Guo

China Design Centre, photo by Phoebe Guo

China Design Centre, photo by Phoebe Guo

Photo courtesy of Bian Xiaodong

Photo courtesy of Bian Xiaodong

Photo courtesy of Bian Xiaodong

Photo courtesy of Bian Xiaodong

[electronicdragonsong]

Colorful Ceramics Accented by Gravity-Defying Drips

Photo courtesy of Bian Xiaodong

Rain falls through the air in smooth curvaceous orbs, instantaneously splitting as it splatters to the ground. Chinese artist Bian Xiaodong’s glossy ceramics resemble these falling droplets, however their inverted forms drip upwards rather than down. The artist crafts his gravity-defying artworks from kaolin clay derived from Jingdezhen —a part of east China’s Jiangxi Province known for its history of crafting porcelain.

After adding the clay to silicone moulds, Bian turns the pieces upside down and lets the natural flow of the clay create a unique shape. In the high-temperature firing process, this ultra-thin clay body further morphs into different forms. Once his ceramics are formed, the artist paints them, using an array of colorful pigments including metallic grey and sunflower yellow. “My work attempts to discover the special texture of ceramic materials, and the beauty that is brought to me by the natural forces,” he explains to Colossal. To view more of Bian’s raindrop-like artworks, visit the China Design Centre’s online gallery.

Photo courtesy of Bian Xiaodong

China Design Centre, photo by Phoebe Guo

China Design Centre, photo by Phoebe Guo

China Design Centre, photo by Phoebe Guo

Photo courtesy of Bian Xiaodong

Photo courtesy of Bian Xiaodong

Photo courtesy of Bian Xiaodong

Photo courtesy of Bian Xiaodong

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[cancersfakianakis1]

Sorafenib in combination with gemcitabine plus cisplatin chemotherapy in metastatic renal collecting duct carcinoma: A prospective, multicentre, single-arm, phase 2 study

Publication date: September 2018

Source: European Journal of Cancer, Volume 100

Author(s): Xinan Sheng, Dengfeng Cao, Jianlin Yuan, Fangjian Zhou, Qiang Wei, Xiaodong Xie, Chuanliang Cui, Zhihong Chi, Lu Si, Siming Li, Lili Mao, Bin Lian, Bixia Tang, Xieqiao Yan, Xuan Wang, Yan Kong, Jie Dai, Xue Bai, Li Zhou, Jun Guo

Abstract

Background

Collecting duct carcinoma (CDC) is a rare type of renal cancer with a poor prognosis. As there are no standard guidelines for the management of metastatic CDC (mCDC), we evaluated the efficacy and safety of combined therapies of sorafenib, gemcitabine, plus cisplatin in patients with mCDC.

Materials and methods

A prospective, multicentre, single-arm, open-label, phase 2 trial (ClinicalTrials.gov identifier NCT01762150) that enrolled 26 mCDC patients with no prior systemic chemotherapy. Patients were treated with sorafenib (400 mg orally, twice daily) combined with chemotherapy (gemcitabine 1000 mg/m2, intravenously for 30–60 min on days 1 and 8, plus cisplatin 25 mg/m2, intravenously on days 1–3, repeated every 28 days for 4 cycles), until disease progression, unacceptable toxicity, or study discontinuation for any other reason. The primary end-points were progression-free survival (PFS) and 6-month PFS rate.

Results

The 6-month PFS rate was 65%, and the median PFS was 8.8 months (95% confidence interval [CI]: 6.7–10.9) with a median overall survival of about 12.5 months (95% CI: 9.6–15.4). The objective response rate was 30.8%, and the disease control rate was 84.6%. The treatment was generally well tolerated. Major grade 3/4 toxicities included leucopenia (26.9%), thrombocytopenia (23.1%), anaemia (11.5%) and palmar-plantar erythrodysesthesia (7.7%).

Conclusions

Though the combination of sorafenib and chemotherapy demonstrated a similar outcome as that of the previously reported regimens in patients with mCDC, this combination may be a suitable option for patients who have low Eastern Cooperative Oncology Group performance status or less metastatic sites.

https://ift.tt/2IWGQp5

[codigokid]

Na China, robôs cuidam de humanos da infância até a velhice

Um exemplo dos novos papéis dos humanoides pode ser encontrado em uma das maiores creches do país, onde três robôs são os destaques da aula

Já estamos acostumados a ver robôs nas linhas de montagem das fábricas, mas na China, líder mundial na produção robótica, já é possível vê-los cuidando de idosos em residências ou brincando com meninos na creche.

Um exemplo dos novos papéis destes humanoides pode ser encontrado em uma das maiores creches do país, chamada “Jardim Dourado” e situada a meio caminho entre Pequim e Tianjin, onde três robôs brancos e de silhueta curva, para que pareçam inofensivos às crianças, são os destaques da aula.

As crianças, de quatro e cinco anos, se aproximam de Keeko, o robô-cuidador, o contam coisas diferentes, e ele ordena as informações e as une em um conto com música.

Na creche, onde as crianças também aprendem kung fu e caligrafia, a ideia é “combinar o tradicional com o moderno”, explicou à Agência Efe uma das professoras, Gao Haiyan, e em meio dessa tarefa Keeko “ajuda a melhorar a expressão oral, a lógica e a noção espacial das crianças”.

Keeko, cujo desenho lembra o Wall-E, do filme da Pixar, também dança com as crianças, faz contas e é dotado de inteligência artificial, recurso que o permite aprender com o tempo.  

“Se todos o dissessem coisas negativas, ele as tomaria como corretas, o que não seria bom para as crianças, portanto intervimos muito para que as aulas fossem positivas”, explicou Chen Xiaodong, responsável pela empresa Xiamen Zhitong, fabricante dos robôs Keeko.

O papel de Keeko nos primeiros anos de vida das crianças chinesas contrasta com o que a 1,2 mil quilômetros de lá, na cidade oriental de Hangzhou, desempenha A-Tai, outro robô, neste caso encarregado de ajudar os cuidadores de um asilo e tratar dos mais de 1,3 mil idosos que vivem no local.

A-Tai, um pouco mais alto que Keeko e dotado de duas simpáticas antenas azuis, é capaz de cantar ópera tradicional chinesa, a música favorita de muitos idosos, e de telefonar para os parentes dos residentes.

Ele também conversa com os idosos – embora às vezes não os entenda, porque um ou outro não fala mandarim padrão – e seu trabalho mais importante é o de lembrar aos idosos e enfermeiros quais remédios tomam e quando, algo de grande ajuda em um asilo enorme como este de Hangzhou.

O criador dos A-Tai, Shen Jianchun, disse que um dia suas “obras “substituirão os cuidadores, embora na creche de Pequim haja mais dúvidas sobre se Keeko, ou uma versão avançada deste, que já está sendo preparada, será algum dia o único professor das crianças.

“O robô é muito avançado, mas um professor tem emoções, que é indispensável para ensinar às crianças”, opinou a professora Gao.

De maneira similar se expressa o inventor do Keeko, Guo Changchen, que dedicou três anos ao desenvolvimento do robô de creche e reconhece que os humanos é que devem ensinar às crianças, embora “ao explicá-las o que é a primavera, o robô possa oferecer mais conteúdo do que um professor”.

A China entrou tarde no mundo da robótica, mas em poucos anos se atualizou e tornou líder mundial na produção de robôs, algo promovido pela campanha estatal “Made in China 2025”, que quer transformar o gigante asiático em líder mundial de alta tecnologia em todos os aspectos.

Em 2016, a China instalou, principalmente em fábricas, 90 mil novos robôs, metade do total mundial e 30% a mais que no ano anterior, embora ainda haja muito potencial se for levado em conta que no país há somente 49 robôs para cada 10 mil trabalhadores, 10 vezes menos que na Coreia do Sul, o país mais “robotizado” do mundo.

Também começam a se desenvolver, e a aparecer timidamente nas ruas chinesas, robôs policiais capazes de controlar o transito. A ficção científica está cada vez mais perto na China.

Fonte: Exame

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[hasansertan]

Canavar Avı İzle – Monster Hunt 2015 Canavar Avı — Monster Hunt 2015 Türkçe Dublaj/Altyazılı İzle , 6.2 İMDB puanlı filmin yönetmeni Raman Hui , Fimde Eric Tsang , Wei Tang , Xiaodong Guo , Chen Yao , Elaine Jin , oyuncular yer almaktadır..

[soundtracktracklist]

Pleasure. Love. Soundtrack

Pleasure. Love. Soundtrack by #DingKe #PleasureLove #Soundtrack #Tracklist #FilmScores #Music #score #drama #ost

Original Motion Picture Soundtrack (OST) from the movie Pleasure. Love. / Pleasure Love (2016). Music composed by Ding Ke. Source: Pleasure Love Movie Style: Original Motion Picture Soundtrack Music by Ding Ke Label: Plaza Mayor Company Format: Digital Release Date: September 1, 2017 Pleasure Love is a 2016 Chinese drama film directed by Yao Huang. The film stars Xiaodong Guo, Yi Sun, Daizhen…

[naivelocus]

Structures of RNA Polymerase Closed and Intermediate Complexes Reveal Mechanisms of DNA Opening and Transcription Initiation

Highlights

•

RNA polymerase closed complex (RPc) structure reveals DNA distortions by σ

•

Intermediate complex (RPi) structure reveals the roles of AAA activator

•

DNA distortion and opening are initiated in RPc and RPi before entering the RNAP

•

RNAP conformation in RPi is significantly different from closed or open complex

Summary

Gene transcription is carried out by RNA polymerases (RNAPs). For transcription to occur, the closed promoter complex (RPc), where DNA is double stranded, must isomerize into an open promoter complex (RPo), where the DNA is melted out into a transcription bubble and the single-stranded template DNA is delivered to the RNAP active site. Using a bacterial RNAP containing the alternative σ54 factor and cryoelectron microscopy, we determined structures of RPc and the activator-bound intermediate complex en route to RPo at 3.8 and 5.8 Å. Our structures show how RNAP-σ54 interacts with promoter DNA to initiate the DNA distortions required for transcription bubble formation, and how the activator interacts with RPc, leading to significant conformational changes in RNAP and σ54 that promote RPo formation. We propose that DNA melting is an active process initiated in RPc and that the RNAP conformations of intermediates are significantly different from that of RPc and RPo.

Keywords

transcription initiation;

DNA opening;

transcription bubble;

sigma factor;

RNA polymerase;

sigma54;

AAA protein;

transcription intermediate complex;

transcription closed complex;

DNA distortion

Introduction

Gene transcription is a fundamental process carried out by RNA polymerase (RNAP), which is conserved from bacteria to humans. The bacterial RNAP has a core consisting of β, β′, two α, and ω subunits (Cramer, 2002 ;  Werner and Grohmann, 2011). For transcription to occur, the closed promoter complex (RPc), where DNA is double stranded and the transcription start site (TSS; +1) DNA lies outside the RNAP, must isomerize into an open promoter complex (RPo), where the DNA is opened into a transcription bubble between −10 and +2 (relative to TSS) and the template strand is delivered to the RNAP active site (Bae et al., 2015; Murakami et al., 2002; Zhang et al., 2012b ;  Zuo and Steitz, 2015). The obligatory isomerization process from RPc to RPo is anticipated to involve multiple intermediate states of RNAP and DNA and is still relatively poorly understood (Gries et al., 2010; Grünberg and Hahn, 2013 ;  Hantsche and Cramer, 2016). Multiple factors are involved in bringing RNAP to the specific promoter DNA sites where transcription is carried out (Browning and Busby, 2016 ;  Vannini and Cramer, 2012). In bacteria, dissociable sigma (σ) factors are utilized to recruit RNAP to the promoter sites (Feklístov et al., 2014 ;  Mooney et al., 2005). The σ factors can be broadly grouped into σ70 and σ54 classes. The σ70 class recognizes consensus promoter sequences at −10 and −35 (upstream relative to TSS at +1) and can form an RPo spontaneously. Many activators of σ70 act as recruitment factors to increase RPc formation through interactions with C-terminal domain of α subunit. σ70 activators can be broadly grouped depending on the binding sites of the activator on DNA: class I activators bind further upstream, while class II activators bind closer to the promoter region (Browning and Busby, 2004 ;  Browning and Busby, 2016). The major variant sigma factor (σ54) forms a class on its own and controls stress-related gene expression, including heat shock, membrane stress, and nutrient starvation genes, thus playing important roles in bacterial adaptation and pathogenicity (Buck et al., 2000). σ54 brings RNAP to the promoter DNA through binding to consensus sequences at −12 and −24 and forms a stable closed complex that rarely isomerizes to an RPo. Instead, activator proteins belonging to the large ATPase associated with diverse cellular activities (AAA) family that bind remotely at enhancer-like sites upstream of the RPc are required (Rappas et al., 2007). The activator proteins, which are also known as bacterial enhancer-binding proteins (bEBPs) and consist essentially of an AAA domain, use their ATPase activity to remodel the RPc into the RPo in order for transcription initiation to proceed (Ghosh et al., 2010 ;  Schumacher et al., 2006). Multiple intermediate states have been proposed to exist during transcription initiation (Davis et al., 2007). One such state has been captured between the AAA activator PspF (phage shock protein F) and RNAP-σ54-promoter DNA complex using an ATP hydrolysis transition state analog, ADP.AlFx (Bose et al., 2008 ;  Chaney et al., 2001). These components provide a model system to capture the structural transitions for forming RPo.

In order to understand the transcription initiation process, which is highly dynamic and difficult to temporally resolve for structural studies, we took advantage of the bacterial σ54 system that forms stable RPcs. In this present work, using cryoelectron microscopy (cryo-EM) and single-particle analysis, we determined the structures of the RPc containing the promoter DNA from −35 to +28 with the characteristic fork junction structure of the RPc at −12/−11 (Guo and Gralla, 1998 ;  Morris et al., 1994) and an intermediate complex (RPi) consisting of RNAP- σ54, the AAA domain of PspF (PspF1-275) in the presence of ADP.AlFx, and the promoter DNA. These structures represent snapshots of a complete bacterial RPc and its subsequent transcription intermediate complex, providing mechanistic insights into a number of key questions, including how (1) RNAP and σ factor engage with its promoter DNA in the RPc, (2) the DNA opening and transcription bubble formation are initiated, (3) the AAA activator interacts with RPc, and (4) conformational changes in σ54, DNA, and RNAP lead to DNA melting for transcription activation. Furthermore, we find unexpected and important roles for the AAA domains of the activators in the promoter DNA interactions and the associated transcription bubble formation.

Author : Robert Glyde, Fuzhou Ye, Vidya Chandran Darbari, Nan Zhang, Martin Buck, Xiaodong Zhang

— ScienceDirect Publication: Molecular Cell