#fmpl

[durang0]

Ever have one of those days?

[khaidir963-blog]

[Dec 25, 2017] Di bawah kaki Gunung ini, anda akan temukan pagar besi, beberapan bangunan dan tanah bekas garapan Perusahaan yang dulu hendak menghancurkan Gunung ini. Berkat izin Allah ﷻ, doa, usaha dan solidaritas masyarakat Antajaya berikut support dari pihak-pihak terkait izin penambangan berhasil dicabut. @keluarbentar @ayodolan @today.bogor @gallery.bogor #savekandaga #fmpl #pesonaantajaya #tolaktambangdiantajaya #keluarbentar #ayodolan #gallerybogor #bogortoday #bogorpisan #bogorkeun #indonesia #lingkarindonesia #natureview #morning #instapic #dailypic #photogram #photodaily #photooftheday #instanusantara #nusantarakita #xiaomiyi (at Bogor, Indonesia)

[juniperpublishersjojdc]

A New Strategy Increases Hair Growth – Combination of Topical Adenosine and Caffeine Hair Tonic

Abstract

Male pattern hair loss (MPHL) and female pattern hair loss (FMPL) are important issues in cosmetic dermatology. The efficacy of hair tonic product containing 0.75% adenosine and 1.5% caffeine was assessed in male and female subjects with MPHL and FMPL. A single-blind, randomized, half-split study was conducted. Effectiveness of the hair tonic was assessed in the improvement of hair density by 6 weeks. In addition, satisfaction on product characteristics and hair shedding reduction were also evaluated. The results showed that the hair density was significantly increased by 40% and 55% at week 6 and week 8, respectively. Subjects scored high level on product characteristics and efficacy. No serious side effect was observed after the application. The results showed that 0.75% adenosine and 1.5% caffeine hair tonic were effective in MPHL and FMPL subjects with a high level of overall satisfaction.

Keywords: Hair Growth Adenosine Caffeine Hair Tonic Alopecia

Introduction

Male pattern hair loss (MPHL) and female pattern hair loss (FPHL) are common situations that generate negative impact in patient self-esteem. MPHL, also known as androgenic alopecia, often showed moderately miniaturization of hair follicles and hair shedding. The cause of MPHL is considered as an androgen-dependent. The major causes of MPHL may include hormonal dysfunction, extracellular matrix proteins in the follicular bed reduction, and local inflammation [1]. In case of FPHL, hair density reduction is often recognized. The miniaturization of hair follicles in FPHL is typically localized in the central-, frontal-, and parietal-scalp area [2]. FPHL is relevant to multiple genes, factors, and environmental influences [3]. Previous study showed that the development of FPHL may be involved with androgen [4]. Another study suggested that FPHL may be associated with metabolic syndrome [5]. The prevalence of MPHL and FPHL has been widely studied. Topical administration of hair tonic containing some active ingredients such as caffeine and adenosine has been reported for their effectiveness in hair loss [6,7]. It is known that androgen is an important regulators of hair loss and 5α-reductase enzyme is a critical factor. Testosterone is metabolized by 5α-reductase enzyme to 5α-dihydrotestosterone (DHT). The high level of DHT could suppress hair growth, which was found in bald scalp. Caffeine could inhibit 5α-reductase enzyme activity leading a reduc tion of DHT in the scalp and improving hair follicle growth stimulation [1]. In the case of adenosine, an activation of adenosine receptor in the scalp could increase the production of fibroblast growth factor [8]. These mechanisms could have effects on hair growth enhancement. Therefore, a combination of both caffeine and adenosine, may provide an effectiveness to male and female with early MPHL and FPHL. The aim of this study was to assess the efficacy of topical adenosine and caffeine hair tonic in comparison with a placebo (vehicle only) in male and female with early MPHL and FPHL. Product attributes satisfaction and hair shedding reduction of subjects were also evaluated and discussed.

Materials and Methods

Subjects and Treatment

A single-blind, randomized, half-split study was conducted. Eight subjects aged 30-51 years with early MPHL and FPHL, who experienced an increase in hair shedding participated in the study. One point five milliliter of 0.75% adenosine and 1.5% caffeine hair tonic was applied to the fixed area on one side of the subject’s frontal scalp, designated as the Treatment area. On another side of the scalp was treated with the same volume of vehicle to serve as the Control area. The subjects were blinded to the treatment, both adenosine-caffeine solution and vehicle were applied twice a dayfor eight weeks. The study protocol was conformed to the declaration of Helsinki and the written informed consent were obtained before the recruitment.

Efficacy and satisfactory evaluation

During the studying periods, the scalp was examined for the sign of skin irritation every day. Fixed area ultra-close image of the hairs and scalp was photographed by IBS-01Pro Intelligent Beauty Scope (Kowa Optics Corp., Taiwan) every week. The total number of hairs was counted using J Micro Vision (version 1.2.7), and the hair density was determined as the total number of hairs per 1 mm2 area in a blind manner by the investigator. Nominal Paired t-test was used for statistical analysis (Excel 2013, Microsoft, USA). The significance of the results was considered at a p-value < 0.05. Secondary evaluation for subject’s satisfactory on product characteristics and hair shedding was assessed using questionnaire. Perceptiveness scores were analyzed using Pareto chart (Excel 2013, Microsoft, USA). In addition, allergic reaction on the scalp was assessed.

Results

Effect of treatment on hair density and overall appearance

All subjects completed 8-week study. None of the participants showed the sign of skin irritation. At week 0, the hair density of the control area was 1.19 ± 0.23 hair/mm2, which was not difference to the treatment area, 1.21 ± 0.25 hair/mm2. No significant differences in hair density or overall appearance in the control area was observed (p-value > 0.2) (Figure 1). In contrast, combination of adenosine and caffeine hair tonic showed a significant improvement in hair density (Figure 1). At week 6, hair density of treated scalp was 1.7 ± 0.27 hair/mm2, significantly higher than that of the control area, 1.24 ± 0.34 hair/mm2 (p-value < 0.05). Similarly, hair density of treated area in week 8 was significantly higher than that observed in the control area (p-value < 0.05). At the end of the study, about 55 percent increment of hair density was observed in the treatment area, indicated the favorable effects of the combination of topical adenosine and caffeine treatment on hair growth. The ultra-close image examples of subject’s scalp were shown in (Figure 2). The images showed dramatic improvement of hair density in comparison to the untreated area, as a similar manner with the result in (Figure 1). The hair density at a hair tonic treated area of subjects at week 6 and week 8 were significantly denser

Product satisfactory assessment

No adverse reactions or allergic reactions due to the application of 0.75% adenosine and 1.5% caffeine hair tonic or placebo hair tonic were observed in any subjects in this study. (Figure 3) showed product satisfactory attribute score, add which were evaluated by all subjects after using the hair tonic. The average scores of product attributes such as texture and smell were 4.88 ± 0.35 and 5.00 ± 0.00, respectively. More than 80% of subjects indicated high level of satisfaction on product’s texture and smell. The level of hair shedding was considered as high (4.44 ± 0.9). More than 100% of the subjects recognized the hair shedding reduction afterapplying the hair tonic. In total, 75% of subjects revealed very high satisfaction on the hair tonic and the overall satisfaction score was 4.46 ±0.43.

Discussion

A combination of adenosine and caffeine in hair tonic significantly enhanced the hair density compared to baseline. Previous study revealed that an application of 0.2% caffeine-based topical liquid on scalp could improve anagen hair in androgenetic alopecia males [6]. An increase in anagen hair may be due to the anagen phase prolongation by caffeine. Caffeine, as a phosphodiesterase inhibitor, could enhance cyclic adenosine monophosphate levels in cells and then increases cell proliferation via stimulation of cell metabolism [9]. The testosterone/dihydrotestosterone-induced miniaturization of hair follicle may be counteracted by caffeine [10]. This mechanism of caffeine may increase the hair density of subjects after hair tonic application. Adenosine also showed effects on hair density improvement as reported in previous studies [7,11]. Adenosine has an effect on the upregulation of fibroblast growth factor production by adenosine receptor A2b activation [8]. In addition, a stimulation of adenosine receptor could decrease inhibitory factor transforming growth factor [12]. The modulation of genes encoding growth factors including fibroblast growth factor and transforming growth factor by adenosine resulted in hair growth enhancement by adenosine. In a similar manner, our hair tonic containing adenosine could improve hair density of subjects. The product attributes such as texture and smell, hair shedding reduction and overall satisfaction scores were considered as high. The high scores confirmed that 0.75% adenosine and 1.5% caffeine hair tonic provided a high level of subject satisfaction and promote an adherence to long-term application.

Conclusion

The hair tonic containing 0.75% adenosine and 1.5% caffeine showed the efficacy in hair density enhancement by 6 weeks compared to baseline. Subjects scored high level on product characteristics and efficacy. No serious side effect was observed after the application. The results showed a high level of subject satisfaction.

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[marutifilters]

Pp filter press India

We, 'Maruti Filter press' are one of the noted manufacturer, exporter, and supplier of Filter Press, Steel Nozzles, Drip Tray, PP Plates & Filter Accessories. Established in 2010 by Atul Kumar Pandey, on The name of “Maruti Filter press”. The company's shipping worldwide is located in Vapi, Gujarat, India. FMPL’s story started in 2010, when the founder, Atul Kumar Pandey, planned and realized the first machines for mechanically pressing chemicals, dyes & intermediates. Our stock series includes Automatic Filter Press, Fully Automatic Filter Press, Membrane Filter Press, Filter Press, Cast Iron Filter Press, Semi-Auto Filter Press, Clarifier Equipment, Filter Cloths, Filter Feed Pumps, PP Frame Type Plates, PP Membrane Plates and PP Recessed Plates. During the opening decades of the main business of the group was the element industry and we were producing wooden filter press & wooden tanks for our customers. We export all over the world.

In the 90s company had started manufacturing Polypropylene plates for filter press. The Maruti Filter press Pvt. Ltd. manufacturing facilities are located in Ahmedabad, Gujarat, India with a staff of 100 employees. FMPL is a worldwide one of the leading manufacturers of Automatic, PP Membrane, PP Filter Press India. FMPL Filter Presses are created for use in liquid/solid division processes appropriated in the medicine, oil mills, starch, effluent processing plants, mining and metal, food and beverages & pharmaceutical business. We provide the best possible solution for our customer's filtration needs.

[leanpick]

Renters fury: Popular Fremantle Markets run like ‘a Russian dictatorship’

Renters fury: Popular Fremantle Markets run like ‘a Russian dictatorship’

Management of the Fremantle Markets has been likened to a “Russian dictatorship” after a popular long-time trader was evicted shortly after voicing support for re-establishing a tenants’ association.

Long-running tensions over rents and advertising fees, allegedly rundown facilities and claims of bullying on the part of operator Fremantle Markets Pty Ltd (FMPL) boiled over last month when Levi…

[hatuey-photographies]

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A post shared by Hatuey Photographies (@hatueyphotographies)

#chateau #Andlau #chateauxdAlsace #GrandEst #alsace #video #HatueyPhotographies #drone #DJI #MAVIC https://www.instagram.com/p/BnvWho-FMpl/?utm_source=ig_tumblr_share&igshid=1cbabgu09gflk

[mykings009]

Bhartiya Kala Ka Itihas : A Book Based on Fine Arts Syllabus (Class - 12) (Hindi, Paperback, D. Kumari) 5% off Price Rs114

Bhartiya Kala Ka Itihas : A Book Based on Fine Arts Syllabus (Class – 12) (Hindi, Paperback, D. Kumari) 5% off Price Rs114

Bhartiya Kala Ka Itihas : A Book Based on Fine Arts Syllabus (Class – 12) (Hindi, Paperback, D. Kumari) 5% off Price Rs114 :-

Highlights Language: Hindi Binding: Paperback Publisher: FMPL ISBN: 9789351550280, 9351550281 Edition: 2014 Pages: 132 Services 10 Days Replacement Policy? Cash on Delivery available?

Offer Price : 114 >> Buy Now << How to get this Product :

Visit Flipkart Product page

L…

[khaidir963-blog]

[Dec 25, 2017] "Sekarang anda bisa menaikinya dan berselfi diatasnya sesuka hati, ketika dulu Gunung ini hendak diratakan anda kemana?" #savekandaga #fmpl #bogor #bogordaily #bogorpisan #bogorkeun #indonesia #lingkarindonesia #nature #mountainpic #paddyfieldview #morning #instapic #dailypic #photogram #photodaily #photooftheday #instanusantara #nusantarakita #instagramers #instashoot #instapost #xiaomiyi #likeforlike (di Antajaya, Tanjungsari-Bogor)

[tudisco]

Una colección de música y sonidos que puedes usar de forma gratuita en los videos que creas y publicas en tudisco.es

La música libre es aquella música que está en dominio público o protegida por una licencia libre, al estilo de la Licencia Pública General, o la licencia BSD que ampara a una parte del software libre. De esta forma, se consigue la máxima distribución y promoción de la música y hace posible que llegue sin obstáculos al público.

La Filosofía de la Música Libre1​ generalmente alienta a los creadores a liberar música usando cualquier lenguaje o métodos que deseen. Una licencia pública de música gratuita (FMPL)2​ está disponible para aquellos que prefieren un enfoque formal. Parte de la música gratuita se concede bajo licencias destinadas a software (como la GPL) u otras escrituras (la GFDL). Pero también hay licencias especialmente para música y otras obras de arte, como la Open Audio License (licencia de audio abierta) de EFF, la Open Music License (licencia de música abierta) de LinuxTag, la Licencia Arte Libre y algunas de las licencias de Creative Commons.

[lilla2010]

😔

[onehundredpercentdun]

veins by fyfe and foundation by years and years

sweet! Veins has a really cool music video too!

[parnassusbooks]

Topic of the day: BIBLIOTHERAPY

According to the newyorker: 

“Bibliotherapy is a very broad term for the ancient practice of encouraging reading for therapeutic effect. . . . For all avid readers who have been self-medicating with great books their entire lives, it comes as no surprise that reading books can be good for your mental health and your relationships with others.”

And this, the news that the Ferguson Public Library has been recognized as Library of the Year by library journal​: 

“In November 2014, when the grand jury failed to indict the policeman responsible for the shooting, another wave of protests and riots broke out in Ferguson. . . . The schools were closed, the streets were in chaos, and the emotions of the residents were at a breaking point. FMPL, concerned for the safety of its citizens, especially children, again stayed open throughout the crisis, providing a place for learning and in which students and teachers could meet to create a level of normalcy. FMPL became the center of community support. It was where people came to get help. Emphasizing its relationship to the people of the community, FMPL placed signs outside the building announcing that it stands with citizens and their rights at a time when police battle protesters.

FMPL did many things to support the emotional recovery of the people of Ferguson. The library created Healing Kits, each a backpack with the library logo on it. Inside are books and worksheets about coping, source material on civil rights history, a list of resources for adults to get free or inexpensive mental health information nearby, and, of course, a teddy bear. Patrons could check out the whole thing and later return the backpack and the books but keep the teddy bear and the worksheets.”

Book therapy is real.

[mykings009]

Tamil (Class - 9) (Tamil, Paperback, Easy Marks Team) 13% off Price Rs139

Tamil (Class – 9) (Tamil, Paperback, Easy Marks Team) 13% off Price Rs139

Tamil (Class – 9) (Tamil, Paperback, Easy Marks Team) 13% off Price Rs139 :-

Highlights Language: Tamil Binding: Paperback Publisher: FMPL ISBN: 9789351550235, 9351550230 Edition: 2014 Pages: 120 Services 10 Days Replacement Policy? Cash on Delivery available?

Offer Price : 139 >> Buy Now << How to get this Product :

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