#fibrous dysplasia

[soongtypehuman]

How’s your fibrous dysplasia treatment going?

Hello, and thank you for asking! ❤️

It’s not going, unfortunately. Currently, there’s no cure for FD, although there is one experimental treatment that’s available to me. The drug has been shown to slow or stop the growth altogether, which would be great. The downside is that preliminary studies showed that when the drug is stopped, the FD grows even faster than before. So me and my doctors are still considering whether or not it’s worth it to give it a try. I’m leaning toward yes, because I can’t really afford to have any more of this grow and crush my brain again.

My very excellent neurosurgeon removed only as much of my skull as was safe (the part directly affecting my brain). Any more goes further into the skull base, which is increasingly dangerous, so it’s sort of on an emergency basis. Otherwise, I’ll need more craniotomies to keep this under control. Boo 😤

Despite the FD and encephalomalacia and seizures, I’m still here. Android nonsense must continue 🫡

[suchawrathfullamb]

Will lay half-buried under the blankets, eyes already half-lidded, voice drowsy.

“I can’t sleep,” he muttered.

Hannibal, pressed against him, glanced down, fingers trailing lazily over his back.

“What would help?”

“Talk about something. Can't be interesting, though, has to be boring,” Will yawned. “Something so unbearably dull that my brain just… shuts down.”

Hannibal quietly hummed, contemplating.

“Perhaps a recipe for a proper cassoulet.”

Will blinked. Suspicious.

“The normal one?”

A pause. Then, smoothly, “Yes. The normal, non interesting one.”

Will squinted but let it go.

Hannibal began, his voice low and even, soothing in the darkness:

“Begin by soaking 500 grams of white beans overnight in cold water. Drain them the next morning and transfer them to a large pot. Cover with fresh water, add a bouquet garni, two whole cloves of garlic, and a peeled onion studded with cloves. Bring to a simmer and cook for one hour.”

Will sighed, already slipping under.

“Meanwhile, render the fat from the duck legs in a large skillet. Remove the legs and brown the pork shoulder, cut into two-inch cubes, in the same pan. Then, slice a garlic sausage into rounds and sear until golden.”

Will let out a soft grunt.

“Mhm.”

“You must then drain the beans, reserving the cooking liquid. Layer the beans, pork, and sausage in a large, flameproof casserole dish.”

Will’s brow furrowed faintly.

“Mmm… all that sounds good.” He shifted. “Great. Now I’m hungry.”

Hannibal exhaled a small, amused breath.

“Then I will list every bone disease a human can have.”

Will gave a sleepy thumbs-up.

“Perfect.”

“Osteoporosis: the progressive loss of bone density, increasing the risk of fractures. Osteomalacia: the softening of bones due to vitamin D deficiency. Fibrous dysplasia: a rare condition where normal bone is replaced with fibrous tissue, leading to deformities.”

Will’s breathing deepened and Hannibal studied him in the dim light. His face had relaxed.

A few more whispered conditions—Paget’s disease, osteogenesis imperfecta—before he realized Will was gone.

A small smile curled at Hannibal’s lips.

He leaned in, pressing a soft kiss against Will’s temple before shutting his own eyes.

The following night, Hannibal was the one struggling to fall asleep.

“I can’t sleep.”

Will, half-draped over him, let out a soft, amused grunt.

“What do you want?”

Hannibal, serious as ever, said, “Something unbearably dull.”

Will smirked.

“Alright. I’ll tell you about the endocrine system of insects. How about that?”

Hannibal’s brows lifted.

“That sounds dreadful. Excellent choice.”

Will began, voice soft and rhythmic, explaining the wonders of ecdysteroids, juvenile hormones, and neurosecretory cells—

“Insects regulate their growth through a balance of hormones. The corpora allata, a small gland near the brain, secretes juvenile hormone, which prevents premature molting. Once an insect is ready to transition into adulthood, the prothoracic gland releases ecdysone, a molting hormone—”

He yawned.

“…which triggers… exoskeleton shedding…”

His voice dragged.

Another pause. Then a faint sigh.

Then—nothing.

Hannibal blinked.

“…Will?”

Nothing.

Hannibal turned his head and found Will—completely out.

He stared at him in mild betrayal.

“Will.”

Will did not stir.

Hannibal scowled.

“I was supposed to fall asleep. Not you.”

A drowsy grunt. Then—

“How did you not fall asleep listening to this?” Will mumbled shockingly.

“I stopped paying attention,” he admitted, “and instead focused on your voice. The way you enunciate, the cadence of your words…”

“Hannibal,” Will groaned.

Hannibal grinned against his skin.

“You have a lovely voice. That’s not my fault.”

Will let out a frustrated little laugh.

“Well. If words don’t work for you, guess we’ll just have to find something else to put you to sleep.”

Hannibal’s eyes glinted.

“Oh?”

[regale--tress]

Hey I'm late to the lore how does the pain feel? My mom had a similar experience with Fibrous Dysplasia if I remember correctly

She describes her bones as Swiss cheese btw

holy shit this is crazy im actually being taken seriously by the doctors at the hospital and they're trying to actually diagnose my chronic pain

[galynakhrushch]

McCune-Albright Syndrome (MAS) is a rare genetic disorder caused by a post-zygotic mutation in the GNAS gene, leading to mosaic activation of Gs alpha protein signaling. It primarily affects the bones, skin, and endocrine system.

Key Features of MAS-1.Fibrous Dysplasia (FD)

• Replacement of normal bone with fibrous tissue, leading to fractures, deformities, and bone pain.

• Commonly affects the skull, long bones, and ribs.

2. Café-au-Lait Skin Pigmentation

• Light-brown, irregularly shaped patches with “coast of Maine” borders.

• Typically appear unilaterally and respect the midline.

3. Endocrine Abnormalities

• Precocious Puberty (most common): Early activation of gonadotropin-independent puberty, especially in females.

• Hyperthyroidism: Autonomous thyroid hormone production.

• Cushing Syndrome: Rare, due to adrenal overactivity.

• Growth Hormone Excess: Leading to gigantism or acromegaly in some cases.

Diagnosis

• Clinical Triad: Fibrous dysplasia, café-au-lait spots, and endocrine dysfunction.

• Genetic Testing: GNAS mutation analysis (in affected tissues, not blood).

• Imaging: X-rays or MRI to assess fibrous dysplasia and bone lesions.

• Hormonal Tests: To evaluate endocrine involvement.

Dear colleagues,pay attention when you perform lips augmentation.Sometimes this kind of pigmentation follows MAS .

👩🏼‍⚕️🙏🏻🇺🇸 🦷My INBDE is coming soon.#dr.galynakhrushch#MAS#INBDE

[teachingrounds]

This week we will present a case series of fibrous dysplasia (FD). FD is caused by an activating somatic mutation in the GNAS gene encoding for the alpha subunit of G proteins. In FD, this mutation causes hyperproliferation and incomplete differentiation of marrow stromal cells to abnormal osteoblasts (NR Riddle, MM Bui. Arch Pathol Lab Med (2013) 137 (1): 134–138).

FD occurs in monostotic and polyostotic forms and is a feature of several syndromes which we will discuss this week.

The monostotic form occurs primarily in the skull and long bones (see Figure).

Case courtesy of Erik Ranschaert, Radiopaedia.org, rID: 14236.

[drdineshkumarortho]

Understanding Benign Bone Tumors: Symptoms, Risks, and Treatment

Bone tumors are abnormal growths that develop within bones. They can be benign (non-cancerous) or malignant (cancerous). Benign bone tumors do not spread to other parts of the body but may still require medical attention due to symptoms and potential complications.

What Are Benign Bone Tumors?

Benign bone tumors are non-cancerous growths in the bones that typically do not spread to other areas of the body. Although they are not life-threatening, they may cause pain, swelling, or structural weaknesses in the affected bone. Some common types of benign bone tumors include:

- Osteochondroma (most common in children and adolescents)

- Giant Cell Tumor

- Enchondroma

- Osteoid Osteoma

- Fibrous Dysplasia

Symptoms of Benign Bone Tumors

The symptoms of benign bone tumors vary depending on their size and location. Some common signs include:

- Persistent bone pain or tenderness

- Presence of a lump or abnormal swelling in the affected bone

- Restricted movement or discomfort in nearby joints

- Increased risk of fractures due to weakened bone structure

Risk Factors and Causes

The exact cause of benign bone tumors is not always clear, but some potential risk factors include:

- Genetic factors: Some bone tumors are linked to inherited conditions.

- Rapid bone growth: Tumors are more common in children and adolescents during periods of rapid bone growth.

- Infections or injuries: In some cases, past trauma or infections can contribute to abnormal bone growth.

Diagnosis of Bone Tumors

Early diagnosis is important to rule out serious conditions such as osteosarcoma (a type of bone cancer). If you or your child experience unusual bone pain, swelling, or other symptoms, consult an orthopedic specialist. Common diagnostic methods include:

- X-rays: Initial imaging to detect abnormal bone growth.

- MRI or CT Scans: Provide detailed images of the tumor and surrounding tissues.

- Bone Biopsy: A sample of the tumor is examined under a microscope to confirm the diagnosis.

Treatment Options for Benign Bone Tumors

Treatment depends on the size, location, and symptoms of the tumor. Common treatment options include:

- Observation: Small tumors that do not cause pain or complications may only require monitoring.

- Medication: Pain management and anti-inflammatory drugs to relieve discomfort.

- Surgery: If the tumor is large, causing pain, or affecting mobility, surgical removal may be necessary.

- Rehabilitation: Physical therapy may be required after surgery to regain strength and mobility.

When to See a Doctor?

If you or your child experience any of the following symptoms, seek medical advice immediately:

- Persistent bone pain that does not improve with rest

- A lump or abnormal swelling in the bones

- Limited movement or joint stiffness

- Unexplained bone fractures

For expert consultation, you can contact

Dr. Dinesh Kumar,

M.B.B.S, M.S. Orthopedic

(specialist in Arthroscopy & Joint Replacement).

📞 Contact: +91-9340640897

🌐 Website: www.drdineshkumarortho.com

📍 Clinic Location: Near Farmtrack Agency, New Bus Stand, Rewa (M.P.)

Conclusion

Benign bone tumors are non-cancerous but should not be ignored. Early detection and proper medical evaluation can help prevent complications. If you notice any unusual symptoms in your bones or your child’s bones, consult a qualified orthopedic specialist for accurate diagnosis and treatment.

[soongtypehuman]

Update on Things

It’s been almost 4 months since the craniotomy that removed the tumor that was crushing my brain. The hope was that the surgery would cure the mild to moderate cognitive issues I was dealing with, or at least stop them from progressing. I’m sorry to say that wasn’t the case, and many of the problems have gotten dramatically worse.

I don’t want to go into too much detail, least of all because it’s boring. My short-term memory, ability to read and write, as well as speak fluidly, have all been affected negatively. I’ve just had another EEG to see if the seizures are continuing, and will have another MRI this week to assess the amount of damage to my brain from the tumor that had been affecting it for years and any damage caused by the surgery, and to check for a stroke. It’s a lot of fuckery I don’t have all the answers for yet. Once I have answers, then I can begin a more exacting treatment for the problem(s).

Unfortunately, as I said above, the problems are affecting my ability to write.

Planning and outlining have always been the backbone of my writing process, but even more so now. Everything is slower and requires a lot more concerted effort and lots of revision.

In short, I’m not able to create as quickly as I once could, although I’m hoping that will change eventually with enough rehab and figuring out new ways to work around my setbacks.

Ideally, I’d like to continue posting every Sunday, just as I have for over a year, but I might have to accept the idea that, as far as things go at the moment, I might not be able to use my writing time for both a weekly ficlet while also finding the time, energy, and focus to work on longer fics. For the time being at least, I might have to switch to posting every other week so I can allot more time and attention to the longer fics.

I just don’t know yet and can’t set anything in stone either way.

But I did want to say something about all of this because I was worried people might see me posting less frequently or posting work that isn’t as long as it used to be and think that I’ve gotten lazy or lost interest. That couldn’t be further from the truth. If anything, my love of this series is one of the few things in my life that brings me joy and that I can count on (my most beloved @monotremer being the main source of that), and one of my biggest motivators in rehab is trying to return to being focused and prolific where my writing is concerned. But I also have to accept that some things may never return to the way they were.

In any event, I hope to keep posting work regularly, but hope everyone understands if I’m not always able to do that.

Updates on what’s coming:

I was working on a longer fic to post to the Data/Lore collection today, but didn’t finish it, so there’s a shorter ficlet in the non-explicit Positronic Rivalry collection instead. The D/L fic should be ready to post next Sunday (fingers crossed). And while all that’s happening, I’m still working on the multi-chapter in the main series that got much bigger than I originally intended. It’s slow going, but it’s going, and my hope is that it’ll be ready to post in July.

[supriyapuram]

Bone Disorders Notes And Short Essays

[strangeartificer]

Easy test for if something is or isn't body horror:

Is the change in the body from violence or was the character born with the disability/disfigurement? PROBABLY NOT BODY HORROR!!!!

Examples of body horror: Brundlefly from David Cronenberg's The Fly, The Thing from John Carpenter's The Thing, zombies are one of those things that can be considered an overlap between gore and body horror.

NOT examples of body horror: Shelley in American Horror Story Asylum, anything in any of the Saw movies, The Scene With The Ear (you know which) in M3gan, The Human Centipede (that's Medical Horror more than anything).

AND ABSOLUTELY FUCKING NOT: Anything that would be considered as a disability you might come across in day to day life like amputees, cleft palates, limb or facial deformations that the character had from birth or developed from a regular medical condition (e.g Lymphatic filariasis or Fibrous dysplasia).

Why does that matter?

Well, for one someone might be able to handle regular gore like you'd come across in slasher movies, but not body horror (that might be just because of a general dislike or because your body turning on you by changing into something 'monstrous' might be a trigger for people) or the other way around (which I guess is rarer, but hey, I'm not judging).

And much more importantly: Disabilities are not a horror movie. Labelling them with a horror trope says some very, very shitty things about how you view visibly disabled people and if you can't tell what those things are, you gotta unpack that shit cause YIKES.

I am begging, begging y’all to understand the difference between gore and body horror please.

Body horror is transformation/monstrous sort of things like a mouth where you shouldn’t have one or like, the shifting bones and whatnot in werewolf transformations. It is where something horrific is happening within the body itself.

It is not a bloody nose, cuts, wounds, injuries ect. That is gore. It is not scars, limb differences, or visual disabilities either.

For fuck’s sake please learn this stuff because the next time I see someone tagging a scarred or disabled character as “body horror” I am gonna lose it.

[ptmasterguide]

Fibrous Dysplasia: A Rare Bone Disorder

Fibrous Dysplasia Fibrous dysplasia is a rare bone disease that causes abnormal bone growth. It occurs when normal bone tissue is replaced by fibrous tissue, which is a type of connective tissue. This can cause bones to become weak and prone to fractures. It can affect any bone in the body, but it most commonly affects the bones of the legs, arms, ribs, skull, and pelvis. The condition can be…

[neogenhomehealth]

Palliative Care at Home in Trivandrum

Palliative Care at Home in Trivandrum

Understanding Bone Cancer: Types, Symptoms, and Treatments

Bone cancer originates from normal cells within a bone. While it can start in any bone, it most commonly affects the long bones of the legs, particularly the thigh bone. It’s important to understand that “bone cancer” does not include cancers that start in other parts of the body and then spread to the bones. These are named after their original site. For instance, cancer that begins in the lungs and spreads to the bones is referred to as lung cancer with bone metastasis.

What is Bone Cancer?

Bone cancer is relatively rare, and different types affect people differently based on age. Some types are more prevalent in children, while others occur primarily in adults. The rarity and complexity of bone cancer make it essential to be informed about its types, symptoms, causes, and treatment options.

Types of Bone Cancer

Bone cancers are classified primarily based on the type of cell where the cancer originates. The most common types include:

Osteosarcoma: This is the most common type of bone cancer, originating in the cells that form bones. Osteosarcoma typically affects teenagers and young adults, though it can also occur in younger children and older adults. It frequently appears in the long bones of the legs and occasionally in the arms. Rarely, it can develop in soft tissues outside the bones.

Chondrosarcoma: Chondrosarcoma usually begins in the bones but can sometimes start in the soft tissues. This type of cancer is most common in middle-aged and older adults and typically affects the pelvis, hip, and shoulder.

Ewing Sarcoma: Ewing sarcoma can start in both the bones and the surrounding soft tissue. It often affects children and teenagers but can occur at any age. This cancer most frequently begins in the leg bones and pelvis, though it can appear in any bone.

Symptoms of Bone Cancer

Bone ache: This is frequently the first symptom, and it can be persistent or come and pass. The pain may worsen at night time or in the course of bodily activity.

Swelling and tenderness: Swelling close to the affected location can arise, frequently along with tenderness to touch.

Weakened bones: Bones might also grow to be fragile, mainly to fractures from minor accidents.

Fatigue: A well known feeling of tiredness that doesn’t improve with relaxation.

Unexplained weight reduction: Losing weight without trying also can be a sign of bone cancer.

When to See a Doctor

If you revel in any of the above symptoms, it’s crucial to consult a healthcare professional right away. Early analysis can considerably affect treatment consequences. Make an appointment with a medical doctor when you have continual bone ache, swelling, or every other concerning signs and symptoms.

Risk elements for bone cancer include:

Inherited genetic syndromes: Certain rare genetic conditions, such as Li-Fraumeni syndrome and hereditary retinoblastoma, can increase the risk of developing bone cancer.

Other bone conditions: Diseases like Paget’s disease of bone and fibrous dysplasia may also elevate the risk.

Previous cancer treatments: Radiation therapy and specific chemotherapy drugs used to treat other cancers can increase the risk of bone cancer later in life.

Diagnosis and Treatment

Diagnosing bone cancer normally entails a combination of imaging tests (like X-rays, CT scans, and MRIs) and biopsies, in which a pattern of the tumor is examined underneath a microscope. Blood assessments will also be performed to test for markers associated with bone most cancers.

Treatment options depend on the type of bone cancer, its location, and its stage. Common treatments include:

Surgery: The goal is to remove the entire tumor. This may sometimes involve reconstructive surgery to repair the bone.

Radiation Therapy: High-energy rays are used to kill cancer cells. This treatment is often used before surgery to shrink the tumor or after surgery to destroy any remaining cancer cells.

Chemotherapy: This involves using drugs to kill cancer cells. Chemotherapy is frequently used for cancers that have spread or are at high risk of spreading.

Coping with Bone Cancer

Facing a bone, most cancers analysis can be overwhelming. It’s important to have an aid system in place that can encompass family, buddies, aid companies, and healthcare experts. Managing aspect effects, keeping a wholesome lifestyle, and staying knowledgeable approximately your condition also can assist in managing the sickness.

Conclusion

Understanding bone most cancers, its types, signs and symptoms, and remedy options is vital for early detection and effective management. While bone cancer is uncommon, consciousness and prompt medical interest could make a sizable distinction in effects. If you or someone you realize is experiencing signs, do not hesitate to try to find a medical recommendation.

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[teachingrounds]

Today's case is a 25 year-old man with leg pain and selling. Radiograph reveals a lucent tibial lesion with groundglass appearance, thinning of the adjacent cortical bone, and no periosteal reaction. These features favor a benign entity. Tc-99-MDP bone scan reveals intense uptake and no other lesions. Findings are most compatible with monostotic fibrous dysplasia. See the full case: https://radiopaedia.org/cases/fibrous-dysplasia-in-tibia

Case courtesy of Erik Ranschaert, Radiopaedia.org, rID: 14236

[underestimated-heroine]

Finally, have a fun Fibrous Dysplasia Friday to my beloved tumblrinas! Farewell, and goodnight!

this one, I had to look up, so good job raising awareness my whimsical mutual!

my god, but what a week it has been. farewell and till next time, traveler.