#evgeniy evtushenko

[shinysoroka]

Sick how Evgeniy Evtushenko wrote a poem about isolation that perfectly describes what's happening to all of us now.

Со мною вот что происходит:

ко мне мой старый друг не ходит,

а ходят в мелкой суете

разнообразные не те.

И он

не с теми ходит где-то

и тоже понимает это,

и наш раздор необъясним,

и оба мучимся мы с ним.

Со мною вот что происходит:

совсем не та ко мне приходит,

мне руки на плечи кладёт

и у другой меня крадёт.

А той —

скажите, бога ради,

кому на плечи руки класть?

Та,

у которой я украден,

в отместку тоже станет красть.

Не сразу этим же ответит,

а будет жить с собой в борьбе

и неосознанно наметит

кого-то дальнего себе.

О, сколько

нервных

и недужных,

ненужных связей,

дружб ненужных!

Куда от этого я денусь?!

О, кто-нибудь,

приди,

нарушь

чужих людей соединённость

и разобщённость

близких душ!

[goneadrift]

Thanks @ymir-me for tagging!

Last song: The Wrong Place by Hooverphonic. Thanks to Eurovision for this gem.

Last film: I can't remember... mostly i just watch games streams recently. But last series was "Suits" (USA)

Currently reading: I have hard time concentrating on anything. So it is either "Introduction to Programming in Java: An Interdisciplinary Approach" for work or poems by Evgeniy Evtushenko.

Currently watching: nothing... only some game plays occasionally (helloooo resident evil 8)

Currently craving: last week it was shaurma but I finally got it. So this morning it is black tea with lemon.

Tagging @traumschwinge @saecookie @niconiconina @musing-and-music

[betamaxvcr]

[flickfeast]

World Cinema Wednesday: I Am Cuba (1964)

World Cinema Wednesday: I Am Cuba (1964)

AKA Soy Cuba. One of the toughest films that I have had to review, so far, for World Cinema Wednesday, this is also one that I knew I HAD to review, as soon as the end credits started to roll. It’s a sublime, beautiful, experience. Part socio-political exanimation of Cuba, part travelogue, the whole thing allows viewers to roam the titular country like a ghost fleeting through buildings,…

[cancersfakianakis1]

Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors

Publication date: Available online 21 June 2018 Source:Cancer Cell Author(s): Marat S. Pavlyukov, Hai Yu, Soniya Bastola, Mutsuko Minata, Victoria O. Shender, Yeri Lee, Suojun Zhang, Jia Wang, Svetlana Komarova, Jun Wang, Shinobu Yamaguchi, Heba Allah Alsheikh, Junfeng Shi, Dongquan Chen, Ahmed Mohyeldin, Sung-Hak Kim, Yong Jae Shin, Ksenia Anufrieva, Evgeniy G. Evtushenko, Nadezhda V. Antipova, Georgij P. Arapidi, Vadim Govorun, Nikolay B. Pestov, Mikhail I. Shakhparonov, L. James Lee, Do-Hyun Nam, Ichiro Nakano Aggressive cancers such as glioblastoma (GBM) contain intermingled apoptotic cells adjacent to proliferating tumor cells. Nonetheless, intercellular signaling between apoptotic and surviving cancer cells remain elusive. In this study, we demonstrate that apoptotic GBM cells paradoxically promote proliferation and therapy resistance of surviving tumor cells by secreting apoptotic extracellular vesicles (apoEVs) enriched with various components of spliceosomes. apoEVs alter RNA splicing in recipient cells, thereby promoting their therapy resistance and aggressive migratory phenotype. Mechanistically, we identified RBM11 as a representative splicing factor that is upregulated in tumors after therapy and shed in extracellular vesicles upon induction of apoptosis. Once internalized in recipient cells, exogenous RBM11 switches splicing of MDM4 and Cyclin D1 toward the expression of more oncogenic isoforms.

Graphical abstract

Teaser

Pavlyukov et al. show that apoptotic GBM cells secrete vesicles enriched with components of spliceosomes to alter RNA splicing in surviving tumor cells and promote their aggressiveness. They identify RBM11 as one such factor that switches MDM4 and cyclinD1 toward the more oncogenic isoforms in recipient cells. https://ift.tt/2JZElI4

[ahtixpict]

https://ru.tsn.ua/svit/umer-izvestnyy-rossiyskiy-poet-evgeniy-evtushenko-833737.html