#er2

[badbirdbrain]

Shadow of the Erdtree Final Boss Spoiler

It should've been Godwyn!

[stevenwilliam12]

The Impact of Lifestyle Choices on HR+/HER2- Breast Cancer Outcomes

Lifestyle choices play a significant role in the management and outcomes of HR+/HER2- breast cancer, a subtype characterized by hormone receptor positivity and the absence of HER2 overexpression. Understanding how these choices can influence patient prognosis is essential for those diagnosed with this cancer type. This article explores various lifestyle factors and their impact on HR+/HER2- breast cancer outcomes.

1. Nutrition and Diet

A well-balanced diet is crucial for overall health, particularly for individuals undergoing treatment for HR+/HER2- breast cancer. Research has shown that certain dietary choices can influence cancer outcomes:

Plant-Based Diets: Diets rich in fruits, vegetables, whole grains, and legumes are associated with a lower risk of cancer recurrence. These foods are high in antioxidants, vitamins, and minerals, which can enhance the body's immune response and overall health.

Healthy Fats: Incorporating healthy fats, such as those found in olive oil, avocados, and nuts, may also play a role in reducing inflammation and supporting heart health during treatment.

Limiting Processed Foods: High consumption of processed foods and sugars may contribute to obesity and inflammation, both of which can negatively impact cancer outcomes. Opting for whole, unprocessed foods can support better health.

2. Physical Activity

Regular physical activity is one of the most significant lifestyle factors influencing HR+/HER2- breast cancer outcomes:

Weight Management: Exercise helps maintain a healthy weight, which is vital, especially for postmenopausal women. Excess body weight can increase estrogen levels, potentially fueling the growth of hormone-sensitive breast tumors.

Improved Survival Rates: Studies have shown that women who engage in regular physical activity have a reduced risk of cancer recurrence and improved overall survival rates. Physical activity can also alleviate treatment-related side effects, such as fatigue and depression.

Recommended Activity Levels: The American Cancer Society recommends at least 150 minutes of moderate-intensity exercise or 75 minutes of vigorous-intensity exercise each week, along with muscle-strengthening activities on two or more days.

3. Alcohol Consumption

Alcohol intake has been linked to an increased risk of breast cancer and may also affect outcomes for those diagnosed with HR+/HER2- breast cancer:

Increased Risk of Recurrence: Research suggests that higher alcohol consumption can lead to a greater risk of cancer recurrence. Limiting alcohol intake may help improve overall outcomes and reduce the risk of new cancer developments.

Guidelines: The American Institute for Cancer Research recommends limiting alcoholic drinks to no more than one per day for women.

4. Smoking

Smoking is a well-established risk factor for many cancers, including breast cancer:

Negative Impact on Treatment: Smoking can interfere with treatment efficacy and increase the risk of complications. It may also lead to poorer outcomes and reduced survival rates in breast cancer patients.

Quitting Smoking: For those diagnosed with HR+/HER2- breast cancer, quitting smoking can significantly improve treatment outcomes and overall health.

5. Stress Management and Mental Health

Psychological well-being plays an essential role in cancer outcomes:

Impact of Stress: Chronic stress can affect the immune system and hormone levels, potentially influencing cancer progression. Finding effective stress management techniques is crucial for patients.

Support Systems: Engaging in social support networks, practicing mindfulness, yoga, or meditation, and seeking professional counseling can help manage stress and improve mental health during treatment.

6. Conclusion

Lifestyle choices significantly impact the outcomes of HR+/HER2- breast cancer patients. A balanced diet, regular physical activity, limited alcohol consumption, avoiding smoking, and effective stress management can contribute to improved survival rates and a better quality of life. It is essential for patients to engage in open discussions with their healthcare providers about lifestyle modifications that can support their treatment and enhance overall well-being. By making informed choices, individuals can play an active role in managing their health and outcomes during their breast cancer journey.

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[stevebattle]

ER2 by Bandai and Evolution Robotics, Pasadena, CA (2003). The ER2 is a small, stout robot with a camera eye, earlike appendages and a video screen on its chest. It includes an innovative new technology known as visual simultaneous localisation and mapping (VSLAM) and can carry out tasks ranging from home security to reading with children. "One of our most attention-grabbing applications allowed the robot and a child to read a book together! With a child sitting cross-legged on the floor facing the robot, ER2 used its visual pattern recognition to identify the book and the current page. By tracking the child’s finger gestures, the robot was able to read sentences aloud, provide word definitions, and play fun sound effects." – ER2: Home robot, Trylonix Corporation.

[sillovn]

Shadow of the Erdtree: Review?

Been itching to get this off my chest, full thoughts on Shadow of Erdtree – there’s alot to say.

~~Major Spoilers Ahead~~

To best summarize, SotE is more Elden Ring - for better and for worse. An attempt to redo the base game in a microcosm; its not unreasonable to call this ER2. In that sense, it succeeds. But, if you have any conceptual problems with base-game ER (too projectile heavy, open world too empty, weapon art spam) – here’s to more of the same.

Encounters

Regular enemies are a more consistent threat. A gripe I have with base-game ER is that ‘Godrick Soldier’ type foes do not have enough dmg/hp, you can quite easily charge headlong into groups of 3-4. Messmer’s rank and file troops have the ‘DS1 hollow’ feel; where even basic enemies will deal enough damage to be worth your respect.

There is also more emphasis on ‘combat problems’ where enemy and environment interacts; from the Forge-Golems that act as walking obstacles in narrow halls, to the Belurat Priests who provide support fire from the roofs. IMO, non-boss encounters can be very compelling and memorable (see. Sens Fortress) and preferable to having a throwaway boss (ER dragons, cave bosses etc.). Which leads to…

Ruined Forges and Catacombs

ER would have benefited from fewer, more fleshed out side dungeons. As it turns out, SotE delivers on that. Catacombs are extensive, each with its own environmental condition. Ruined Forges are almost pure-puzzle areas, with no end boss.

Some may call it a gimmick, but I like that side-dungeons present a different pace/challenge type – they’re not just tiny-underbaked versions of regular story dungeons. There is an understanding that the compelling part of a Ruined Forge *is* the puzzle element – there's no obligation to put an end boss if you don't need one.

As a sidenote, I haven’t looked at how the PvP scene is shaping out, *BUT* I need to see fight clubs in Ruined Forges.

Overall, biggest strength of SotE is the quality of the dungeons

Player NPC type battles are much better. They now incorporate jumps to avoid and punish your attacks etc.

Furnace Golems are... eh? its fine to fight once.

The World

My biggest gripe with ER as a whole is that it has many elements that make a better ‘play it once’ game, but also worse for subsequent runs. If you didn’t like how Giant’s Mountaintops had vast (albeit very scenic) sections with no gameplay, the Shadow Lands are just more of that, while also much more vertical than any previous map.

These are the most striking vistas in ER, and I dread having to climb Jagged Peak ever again…

SotE also includes elements that really encourage ‘map-scraping’ for its own sake; Scadutree Fragments, whole areas locked behind tiny ravines, arbitrary treasure placement. The open-world feels exhausting. Then, there is the double down on questionable concepts...

rare consumables/materials

rare drop-only equipment

weapons dropping from 1 *very-specific* enemy as opposed to anything that wields it (see. Black Knight weapons)

Treasure placement/choice is just strange. Many new weapons/spells are just lying on random corpses, meanwhile there's so many treasure chests that contain things like currency runes and smithing stones.

New Weapons, Spells, Ashes of War

The new weapon classes are all winners to me, they are compelling on the moveset level, not just numbers and AoW options. The main issue now, is that many old weapons feel only relevant due to numbers. For example: I beat the evergoal NPC’s by mashing with a Great-hammer. Effective? Sure, but I dislike how even large weapons are fast in absolute terms. Outside of colossal and polearm types, weapons are very mash-y (TBF this is an ER problem, not SotE specific). The throwing variants of weapons are a nice surprise (ranged attack really spices up the default axe moveset). Main problem? The thrown versions are banned from using many AoW, so the already limited choice is even smaller.

New spell are in an odd place - being very cool but also likely bad. It is nice to see ‘high-end’ spells (Incants especially) that are appropriately interesting and finally make use of ER’s inflated stats (eg. Minor Erdtree). Caster equipment in ER is *very plain*, and SotE (finally) adds a universal sorc-incant staff (which should have existed in the base-game anyway). Besides that, the new seals are nothing to write home about.

New ashes are solid all around, only gripe would be that many (Wing Stance etc.) are just ultra-specific to a particular weapon class. Personally, very happy with ‘We have Death’s Poker at home’ and Crucible Wings.

Lore

Will only briefly touch lore, as there’s just *so much* to say that it deserves a separate entry. Ill sum it with the following.

Main plot doesn't have an interesting payoff (also fucks with source material in weird ways)

Ending is bad (very funny)

Marika-Messmer get fleshed out as people. But doesn't really explore the how of Marika's ascension or Messmer's curse to any degree Im happy with.

Dragon plot ties up surprisingly neatly, and very directly too. Unusual by FROM standards.

Finger lore really delivered - answers some questions, poses deeper more interesting ones.

Crucible(s) gets fleshed out, but is (somehow) even less coherent now.

[tvrded]

What was the end tesults from ur google boyfriend survey or what evah??

my favourite answers

"can e do something fun maybe or U can gor me"

"ҨfS,/u;Fk@,p͙X O! e U?G &֭HTy˟{+WC TY)(A Kn%/4E}JϡE,ER2{!C{#b!2wrlȵ L'u|G <Z"<dH/ydҡ" c+ZhU|Hҭ~v} Hַ&~yv(_}&r^P|0.x)":(=Xfbv)n_f/OC4jX"

(it just goes on like this)

"i think if you got laid that would fix like 2 of your many problems <3"

BTW this isnt whom Id date the most just the answers I found most amusing

[royal-confessions]

“CR3's 'modernized' Coronation just confirmed that his is a transitional reign, bookended by the much-loved ER2 and what will likely be a still more loved WR5.” - Submitted by Anonymous

[craftyballoonwinner]

I want more Miquella and Radahn

Simply put I would love another game.

Ok hear me out. I know everyone thinks he's a little evil shit and Radahn was mind controlled. I chalk this up to people who didn't enjoy the last boss of the DLC. I respect these opinions.

But I really, really like these characters.

I saw a post on here talking about Elden Ring 2 with his age of compassion and I thought that would be so cool.

Like the tarnished fucked off to the moon with Ranni. Or you burned it down. Or tarnished is just elden lord. This would leave the game wide open for Radahn and Miquella to pick up the pieces of what was left of the Lands Between and just THINK OF THE STORY TELLING HERE.

Miquella and Radahn having a defined relationship whether platonic, romantic or co rulers.

Discovering the tarnished killed fucking everyone from Rykard to the Elden Beast. (WTF??)

SPENDING MORE TIME IN THE LANDS BETWEEN.

Navigating peace with ALL the left over factions. (Player choice if they chose to follow Radahn or Miquella)

Putting together the events of the base game.

Healing Caleid.

Setting up therapy for Rennala.

Choosing a place to reside as kings since Lyndell was fucked over by the tarnish and their goal.

Radahn taking a liking to riding the giant hippos like Giaus rides his boar.

Miquella trying to restore order and being BOMBARDED with a land slide of requests (mostly Kennith Height) until Radahn has enough and drags him off for a sabbatical in the haligtree. Good luck finding him there fuckers!

Navigating the evergoal to get there together (team building or romance- you decide)

Mourning Malenia.

Miquella and Radahn getting used to their new bodies.

Dealing with the trauma of St. Trina.

Deciding how this is going to work and if it can.

The Hornset and Mogwyn Dynasty sending their best warriors. Someone could even be grafting scions again to send after them. There's so much that could happen!

Jar people support groups.

Like I could go on and on but I just want more. I'm sad that it's over.

But what about you? What would you like? You don't have to agree with anything I've listed. It's over and done with so cares really- I get that stance. But if you got ER2 what would you want?

[subverbaldreams]

asku for wip meme: ik the pierce/logan one is the only one rly active but imma be evil and ask abt ER book 2 >:D

UR SO CRUEL U KNOW THE ANSWER TO THAT

;----------------------;

ER2 summary: Michael slowly falls in love but is stupid about it; fortunately for him, he's very tall and handsome.

Kristoph shows up fashionably late and quickly realizes everything is fucked; his boyfriend realized it first though and won't let him forget that.

Devyn is finally *actually* safe(ish) so HellO to the P part of PTSD.

Did I say "ish"? So there's that.

Rheven is adorable and Kenward, bless his mercenary heart, tries his darnedest.

Koval is the Goodest Boi; he can do no wrong.

Vamp sorcerers do esoteric shit. One of the other bloodlines makes a guest appearance. The king of vampires takes an interest in Michael and decides he's pretty when he's in pain, so he winds up spending a lot of time in pain.

There's a weird human cult community that does [redacted] and some vampires [redacted] until [redacted].

Jason [redacted].

Sexy things happen. Trauma things happen (sexy). Shaw shows up (unsexy).

200,000+ words down and there's an ending just around the corner! If only someone would write it!

[guerrerense]

Onderweg met de trein por Peter Velthoen Por Flickr: електричка ER2 349 station Oekraïne - Україна 11-7-2005 В дорозі потягом. En route by train. I lost the note were it was. Does anyone have a suggestion?

[postsofbabel]

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[pacosemnoticias]

IP contrata obras de 88,5 milhões de euros para construir variante de Évora e beneficiar IP8 até Beja

A Infraestruturas de Portugal procedeu à contratação das empreitadas de construção da Variante Nascente de Évora e da Beneficiação do Itinerário Principal (IP) 8 entre Ferreira do Alentejo e Beja, que inclui uma variante em Beringela.

Em comunicado, a Infraestruturas de Portugal revelou que estes dois contratos de investimento no âmbito do Plano de Recuperação e Resiliência (PRR), financiado pela União Europeia, envolvem um investimento global que ascende a 88,5 milhões de euros.

Segundo a empresa, a empreitada de construção da Variante Nascente de Évora, no valor de 54,9 milhões de euros, visa a construção de uma nova ligação rodoviária alternativa ao atual troço do IP2.

Essa variante terá cerca de 12,8 quilómetros de extensão, fazendo a ligação entre o Nó de Évora Nascente da Autoestrada 6 (A6), “imediatamente após a praça de portagem”, e a conexão com o atual IP2, em S. Manços, no concelho de Évora.

Já a obra de beneficiação do troço do IP8, com 22,5 quilómetros de extensão, atinge o valor de cerca 33,6 milhões de euros, afirmou a empresa.

O projeto vai ser construído entre a Rotunda com a Estrada Regional 2 (ER2) em Ferreira do Alentejo e a Rotunda com o IP2 em Beja.

O objetivo é “a reabilitação estrutural da via, promovendo a melhoria das condições de mobilidade, circulação e segurança no IP8”, indicou a Infraestruturas de Portugal, realçando que a empreitada “inclui ainda a construção de uma variante à localidade de Beringel, com 2,5 quilómetros de extensão”.

“Os contratos serão remetidos para avaliação do Tribunal de Contas a fim de obterem o necessário visto prévio”, disse a empresa.

No que respeita à Variante Nascente de Évora, em junho de 2021, a Infraestruturas de Portugal (IP) já tinha anunciado um concurso público para a elaboração do projeto de execução da obra, que incluía uma análise à viabilidade do aproveitamento do traçado e das estruturas construídas no âmbito da empreitada de requalificação do IP2, incluída na então subconcessão Baixo Alentejo.

Durante a empreitada de requalificação, que acabou por ser suspensa em 2011, foram desenvolvidos trabalhos de terraplanagem e construídos viadutos, até hoje abandonados.

A construção da variante tem sido reivindicada em Évora, nos últimos anos, para permitir desviar o trânsito da cidade, cujo centro histórico está classificado como Património Mundial pela Organização das Nações Unidas para a Educação, Ciência e Cultura (UNESCO).

Em comunicados divulgados recentemente, as estruturas distritais de Évora do PSD e do PCP congratularam-se com a adjudicação da empreitada, o mesmo acontecendo com o deputado parlamentar do Chega eleito por Évora, Rui Cristina, que reclamou, contudo, outras obras complementares.

“É necessário incluir a requalificação do troço rodoviário de 22 quilómetros entre S. Manços até à cidade [de Évora] e do troço nascente até à A6, através da Estrada Nacional 114”, exigiu.

Em 08 de julho, a IP anunciou a consignação de uma outra empreitada do IP8, para duplicar as faixas num troço entre Sines e a A2, num investimento de 45 milhões de euros, igualmente financiada pelo PRR.

[stevenwilliam12]

The Psychological Impact of an ER+ Breast Cancer Diagnosis: Coping Strategies

Receiving a diagnosis of estrogen receptor-positive (ER+) breast cancer can be a life-altering experience, bringing a whirlwind of emotions and challenges. Beyond the physical aspects of treatment, the psychological impact can significantly affect patients and their loved ones. Understanding these effects and implementing effective coping strategies can help individuals navigate their journey with greater resilience.

Psychological Impact

Emotional Turmoil: A diagnosis of ER+ breast cancer can trigger feelings of fear, anxiety, and sadness. Patients may worry about treatment outcomes, potential recurrence, and the impact on their loved ones.

Identity Changes: Many individuals struggle with changes in their body image and self-esteem due to surgeries, hair loss from chemotherapy, or hormonal changes. These shifts can lead to feelings of loss and confusion about one’s identity.

Social Isolation: Patients may feel isolated from friends and family, particularly if they perceive that others do not understand their experience. This can exacerbate feelings of loneliness and depression.

Concerns About the Future: Uncertainty about prognosis and future health can lead to chronic stress and worry, affecting mental health and overall quality of life.

Coping Strategies

Seek Support:

Join Support Groups: Connecting with others who have faced similar challenges can provide comfort and understanding. Support groups offer a safe space to share experiences and feelings, helping to alleviate feelings of isolation.

Talk to Loved Ones: Open communication with family and friends about fears and feelings can foster stronger relationships and provide emotional support.

Professional Counseling:

Therapy Options: Consider seeking support from a psychologist or counselor who specializes in oncology. Therapy can help process emotions, develop coping strategies, and manage anxiety and depression.

Mindfulness and Relaxation Techniques: Practices like meditation, yoga, or deep-breathing exercises can reduce stress and promote a sense of calm.

Stay Informed:

Educate Yourself: Understanding ER+ breast cancer, treatment options, and potential side effects can empower patients, reducing fear of the unknown. Knowledge allows patients to engage actively in their treatment decisions.

Maintain a Healthy Lifestyle:

Physical Activity: Regular exercise has been shown to improve mood and reduce anxiety. Activities like walking, swimming, or yoga can be beneficial.

Nutrition: A balanced diet can enhance overall well-being and energy levels, helping to combat treatment side effects.

Engage in Creative Outlets:

Express Yourself: Writing, painting, or engaging in other creative activities can serve as a powerful outlet for emotions, allowing for self-expression and reflection.

Set Realistic Goals:

Focus on Small Achievements: Setting achievable daily or weekly goals can help create a sense of purpose and accomplishment, counteracting feelings of helplessness.

Practice Self-Compassion:

Acknowledge Your Feelings: Recognize that it’s normal to experience a range of emotions. Allowing yourself to feel sadness, anger, or fear is part of the healing process.

Be Kind to Yourself: Practice self-care by indulging in activities that bring joy, comfort, and relaxation.

Conclusion

The psychological impact of an ER+ breast cancer diagnosis is profound and multifaceted. By implementing coping strategies and seeking support, patients can better navigate the emotional challenges that accompany their diagnosis. Remember, it’s essential to prioritize mental health and well-being during this journey. Connecting with professionals, loved ones, and support groups can provide invaluable resources, fostering resilience and hope in the face of adversity. With the right tools and support, individuals can find ways to cope and thrive despite the challenges of their diagnosis.

[53rdcenturyhero]

70 years in waiting, and he'll only get a bad reedy A4 photocopy in an IKEA frame at the side of the entrance hall, above gum throwing reach. Schools never had a picture of ER2 so this is distracting us from... (big list) . Distraction politics.

1. Piñata at lunch break

[kito4258]

Kito Radio Remote Control System | Kito India

Integrate Kito Radio Remote Control System with Kito EQ & ER2 series Electric Chain Hoists to further increase the ease of operation.

https://kito.co.in/kito-radio-remote-control-system/

[untilthenexttee]

Evnroll Introduces New 38 Tour Spec Putter Line

CARLSBAD, CALIFORNIA, May 1, 2024 – Evnroll, the award-winning putter line featuring patented ‘SweetFace’ Technology, has added to its product line with the launch of three of its Neo Classic models in the new 38 Tour Spec line – the ER2 wide blade, ER5 mallet and ER8 mallet. “When the Belly putter was banned in 2016 with the USGA’s no-anchoring rule, the “Counter-Balanced” putter was born,” says…

[collectingall]

∀ Graded 2023 Bowman U Chrome Drake Maye #ER2 UD Early Risers Football Card PSA 10 http://blog.collectingall.com/T6Dhl5 📌 shrsl.com/4fuj5 📌