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vague-mintyboy · 4 months ago

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I am rewatching Misfits and Magic in preparation for the new season, and I am determined to figure out the exact date when The wizarding world of Misfits and Magic (WWMM for short) cut off technologically. I mean like Brennan keep saying, everything is technology so at some point the world was contemporary. So I will be keeping track of specific technology that stands out. I will update this post as I watch.

I will not count technologies an individual may have as some wizards are shown to have family etc in the NAMP world. This is a list of the wildly accepted technology.

So far no travel technology canonically described (in no real order)

Notable known technology

- Velocipede bicycles

Invented June 12, 1818.

So far this is the most recent date we can get. This specific type of hike also comes up in episode 2 so it isn’t a one-off from a more open-minded character. Dr. Boodle even implies that the school offers students complementary velocipedes in episode 2, so this technology is not considered out of place in the WWMM

- Tobacco pipe

While pipes in general can be traced back to Ancient Egypt, English Pipes do not become popularized until the late 1500s with the colonization/subsequent genocide of Indigenous Americans. This is when Tobacco in particular gets pairs with Pipes as it is native to the Americas.

- Parchment

Invented in Pergamum, 1500 BC.

However, it is not popular in England until seemingly 1500 CE, so this date keeps coming up.

- Indoor plumbing for water but not toilets

(so far unclear if that includes sinks or a water pump or what)

I knew this was going to give me trouble. Also TW a lot of literal shit talk.

Plumbing in general can be dated back to the Neolithic period but Aabria does say they have water pipes. If we are assuming these pipes are iron, and the typical shape then this would date to 1455

However, we can get more specific as the use of toilets/plumbing integrated gives us a cut off date. While again there are examples of various cultures using water to clean their versions of toilets, the flushing toilet is not invented until 1775.

This creates a problem. As shown Velocipedes were not invented at 1818. However, this could mean than instead of a single cut-off date, the transition to seclusion was slightly more gradual. As the lack of toilets seems to me more systematically in-forced (while velocipedes are easier to integrate) I am confident to say that by 1775 the wizarding world began to close itself off but had not fully done so. It also makes sense for typical public toilets/latrines not to be integrated into wizarding society as those are unhygienic and so a magical solution would be warranted, and that would still fit the contemporary needs. Furthermore the idea of pooping somewhere and then cleaning it matches with the social etiquette of latrines (versus just magicing away the waste pre-actual pooping.) this shows that socially pre-1755 the wizarding board was contemporary with medieval Europe.

- Pushbroom

Evan’s broom is specifically called a pushbroom. The pushbroom’s patent was filed in 1950! However, I could attribute this to the broom shop owner being particularly connected to the outside world? Or maybe it is just an older broom that looks similar to a pushbroom so Evan calls it that.

- Mop

Traditional mops (not just rags) seems to appear by the late 15th century for ships, and the idea is popular in association with more general cleaning by the 1840s.

- toffee

Toffee first becomes a word for candy around 1843. However, this was a general word for taffy-like candy. English toffee seems to be often dated to from around 1890s but that date is unreliable. https://www.etymonline.com/word/toffee

- Tea

Tea does not arrive in Europe until the 1600s from China. At the start, tea was still consumed like Chinese tea (no milk or sugar, etc). England then takes over the industry in 1858 with the government taking over the East India Company / relying on colonized India for tea production instead of China. However, this didn’t really affect popular culture / tea consumption habits until the 1900s and then really boomed in WWII.

I do admit that a handful of savvy more-modern Wizards could have taken tea’s popularity and broke into the untapped Wizard Market. However, even then you’d expect to see some sort of cultural difference (like how McDonald’s in different countries all have different menus, etc).

Notable technology not known about

- Nukes

We know definitively that nukes are not generally known about, so the WWMM is definitely completely closed off by 1945 bc even if there was slight connection people would know. Even if the WWMM closed after because of nukes people would know.

- Radio

Repeatedly radio is confirmed to be foreign. Radios were invented in 1899, and audio transmissions were then added in 1906.

Conclusion so far:

The WWMM was relatively contemporary with NAMP Britain through the 1500s. However, by 1755 WWMM began to close itself off. At least, architecture stopped being updated with modern plumbing which reflects a larger systematic shift. However, there was still a steady exchange of ideas through the 1840s, as tea, velocipedes, toffee, and modern mops all are treated as everyday items. However, by 1906 major technological trends went unnoticed, and certainly by 1945 the WWMM was completely cut off from world-wide news.

I feel like it is likely that by 1906 the WWMM stagnated completely and looked relatively the same to season 1’s world.

Currently, my theory is the political strife leading up to WWI, likely before the actual war, lead to the intellectual closure of the WWMM. However I will repost/update this with any new info. Also feel free to add your own insights.

#dimension 20 #misfits and magic #aabria iyengar #aabria my beloved #aabria what have you done to me #brennan lee mulligan #erika ishii #lou wilson #evan kelmp #dimension20 #dropout #misfits and magic season two

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plumberswoodlandstx · 3 months ago

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#plumbing #plumbers #water heater

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shiorihyugawrites · 1 month ago

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Steadfast Hearts

In the aftermath of global war, alliances are forged, and new bonds are tested. Dr. Tiana Belrose, a brilliant Androsian engineer, arrives in Paradis with cutting-edge technology, her country's hopes on her shoulders, and a guarded heart. Her brilliant inventions are the reason why Marley invaded and ravaged her country, but Tiana refuses to sit back and do nothing.

Assigned to be her personal guard, the stoic and battle-hardened Captain Levi Ackerman is known for his discipline, but as they spend countless hours together, he finds himself drawn to the woman he’s sworn to protect.

In the midst of battles against Marley, political intrigue, and the weight of their responsibilities, an unexpected romance begins to blossom between two unlikely hearts. As tensions rise on the battlefield and within their own ranks, Levi and Tiana must navigate their feelings in a world that doesn’t allow for weakness.

Love was the last thing either of them expected to find in the midst of war, but it may be the only thing that saves them. (Levi x Black OC)

Chapter Three

As the group continued their trek through the dimly lit corridors of the headquarters, the tension from earlier slowly began to ease. The initial shock of Demetri’s presence was giving way to a cautious curiosity, though the Scouts remained alert, their eyes darting to the android every now and then. Tiana walked beside Levi, feeling the weight of his presence and the occasional glances he shot her way. Erwin and Hange were deep in conversation about potential collaborations, while Isaac hovered close to Tiana, his expression a mix of protectiveness and lingering frustration.

Suddenly, Demetri halted mid-step, his glowing blue eyes narrowing slightly as if focusing on something unseen. “Alert,” he announced in his calm, even tone. “I am detecting a malfunction in the structural integrity of this facility. There is a broken pipe valve within the wall to our left. If not repaired promptly, it may cause significant water damage to the lower levels.”

The Scouts froze, immediately on guard. Levi’s hand moved instinctively toward the hilt of his swords, but Tiana quickly raised a hand to calm them. “It’s alright,” she said. “Demetri’s sensors are highly advanced. He’s just… trying to help.”

Erwin raised an eyebrow, clearly intrigued. “A broken pipe valve, you say? We’ve had some issues with the old plumbing here, but it’s been difficult to pinpoint the exact problem.”

Tiana nodded, turning to Demetri. “Demetri, run a full diagnostic scan,” she instructed. “Let’s get a clear view of the damage.”

Demetri’s eyes pulsed with a soft blue light as he processed her command. “Initiating diagnostic scan,” he replied. “Scanning… Scanning… Analyzing structural anomalies… Assessment complete. The valve is located approximately one meter within the wall at this point. It appears to be corroded and is leaking water into the surrounding framework.”

Tiana’s expression grew focused, her mind already running through potential solutions. “Okay,” she said, more to herself than anyone else. “We’ll need to replace the valve and seal the leak before it causes more damage. Demetri, prepare to remove the paneling.”

The scouts watched in stunned silence as Tiana spoke in rapid, complex scientific terms to Demetri, her words flowing effortlessly. Hange leaned in closer, trying to catch on, but even she struggled to keep up with the technical jargon.

“What… what are they saying?” Hange whispered to Erwin, who merely shook his head, just as bewildered.

“Your guess is as good as mine,” Erwin replied, his tone amused. “But I think we’re about to find out.”

Tiana turned to one of the Androsian soldiers who was carrying her belongings. “Hand me the toolkit,” she requested, and the soldier immediately obliged, pulling out a small, pink case adorned with colorful stickers of flowers, stars, and cute animals.

Levi raised an eyebrow at the sight, his expression a mix of surprise and something akin to amusement. “Is that your… toolkit?” he asked, his tone flat but with a slight hint of incredulity.

Tiana grinned, undeterred by his skepticism. “Yes, it is,” she said, popping open the case to reveal a neatly organized set of tools—all in various shades of pink, each one with a small, sparkly charm attached. “Just because I’m fixing pipes doesn’t mean I can’t have a little fun with it.”

Hange chuckled, clearly delighted. “I love it!” she exclaimed. “Practical and stylish—what more could you ask for?”

Tiana nodded to Demetri. “Demetri, use your laser to cut away the paneling. Let’s see what we’re dealing with.”

Demetri’s right hand transformed with a smooth, mechanical whir into a small, precise laser cutter. He aimed it at the wall and, with a steady hand, began to slice through the paneling, the thin red beam cutting cleanly through the metal. The Scouts watched with a mix of awe and unease, clearly unused to such advanced technology.

Within moments, Demetri had removed the paneling, revealing a network of old, corroded pipes. A steady trickle of water dripped from a damaged valve, staining the surrounding stone with moisture.

“Got it,” Tiana muttered, slipping on a pair of pink gloves from her toolkit. She quickly selected a set of tools and began working with the fluid precision of someone who had done this a thousand times before. “We’ll need to replace this valve entirely and seal the joint. The corrosion’s pretty extensive, but it’s manageable.”

Hange watched, utterly captivated. “You’re really something, Tiana,” she murmured. “I’ve never seen anyone work like this… and with so much style!”

Tiana flashed a quick smile, her hands moving deftly as she removed the damaged valve and replaced it with a new one. “Thank you, Hange. I’ve always believed that even the most technical work can have a bit of flair.”

Levi watched her closely, his eyes narrowed in concentration. He had to admit, there was something impressive about the way she moved, her confidence and skill evident in every precise motion. “You’re fast,” he remarked, unable to keep a hint of respect from creeping into his voice.

Tiana glanced at him, her smile widening just a bit. “In my line of work, speed can be the difference between success and disaster.”

Within three minutes, she had completed the repair, her hands moving with practiced ease as she tightened the new valve and sealed the joints. “Alright, Demetri,” she said, stepping back, “weld the paneling back into place.”

Demetri’s laser transformed into a welding torch, and he carefully reattached the metal paneling, sealing it seamlessly with quick, efficient movements. “Repair complete,” he reported. “The integrity of the structure has been restored.”

The Scouts stood in stunned silence, clearly impressed. Hange was the first to break the silence, clapping her hands in delight. “That was incredible!” she exclaimed. “You just… fixed it. Like it was nothing!”

Tiana shrugged modestly, packing up her toolkit with the same efficiency she had shown in her repairs. “Just another day at the office,” she said with a wink.

Erwin nodded, clearly impressed. “You’ve certainly proven your worth already, Dr. Belrose—Tiana,” he corrected with a small smile. “We could use more people like you around here.”

Levi sheathed his swords, his expression softer than usual. “Just make sure you don’t go around fixing everything,” he said dryly. “We wouldn’t want you to run out of things to do.”

Tiana chuckled, her eyes meeting Levi’s with a hint of playfulness. “I’ll try to pace myself, Captain.”

As they resumed their walk, the tension had noticeably lessened, replaced by a growing sense of camaraderie. Tiana had made an impression, not just with her skills, but with her spirit and approach to her work. And as she continued beside Levi, she couldn’t help but feel a spark of excitement about what lay ahead.

They continued to the briefing room and Isaac, still walking close to Tiana, couldn’t help but puff up with pride. His chest swelled, and his voice rose with each word as he turned to the gathered scouts, particularly toward Erwin, Hange, and Levi, who were still nearby.

“You know,” Isaac began, his tone brimming with enthusiasm, “Tiana isn’t just an engineer. She’s a genius. She’s accomplished things most people can’t even dream of. Do you know she has six degrees? Six! And she got her first one when she was only thirteen years old!”

The scouts exchanged surprised glances. Even Erwin, who rarely showed much emotion, raised his eyebrows in mild astonishment. “Thirteen?” he repeated, turning his gaze to Tiana. “That’s… impressive, to say the least.”

Hange’s eyes widened, sparkling with renewed excitement. “Thirteen?! Wow, Tiana, you’re full of surprises! I mean, I thought I was smart, but you’re on a whole different level!” She laughed, her admiration clear in her voice.

Tiana felt her cheeks flush with embarrassment, a faint pink coloring her deep brown skin. She wasn’t used to this kind of attention, especially not from people she had just met. “It was a long time ago,” she said modestly, trying to downplay her accomplishments. “I was just… very focused, I guess.”

But Isaac wasn’t finished. He was in full bragging mode now, clearly enjoying the attention on Tiana. “And that’s not all,” he continued, his grin widening. “The engineering department at the Androsian University was renamed after her because of her contributions. She’s the reason Androsia is so technologically advanced today. We owe a lot of our progress to her innovations and inventions.”

Levi, who had been listening quietly, glanced at Tiana with a mixture of curiosity and something else—perhaps a flicker of respect. “The entire department?” he asked, his tone flat but tinged with intrigue. “That’s quite an honor.”

Tiana’s blush deepened. She cast a quick, imploring glance at Isaac, hoping he would take the hint and stop, but he seemed completely oblivious—or perhaps he just didn’t care. “Yes, well… they were very kind,” she said, trying to deflect. “It’s not as grand as Isaac makes it sound.”

Isaac chuckled, clearly enjoying her discomfort. “Don’t be modest, Tiana. You deserve the recognition. You even taught there as a part-time professor before Marley launched their attack! She’s not just a genius; she’s also an incredible teacher. Her students loved her.”

Hange looked like she might burst with excitement. “A teacher, too? Is there anything you can’t do, Tiana?” she asked, clearly impressed. “You’ve got to tell me more about your work—your inventions, your research. I’m dying to know!”

Tiana let out a small, nervous laugh, trying to keep her cool. “I’d be happy to share,” she said, her voice soft but steady. “But really, I’m just here to help in any way I can. I’m not used to all this… praise.”

Erwin smiled gently, sensing her embarrassment. “It’s clear you’ve accomplished a great deal, Tiana,” he said. “But I imagine you’re here not for accolades, but for a new challenge.”

Tiana nodded, grateful for Erwin’s understanding. “Exactly,” she agreed. “I’m here to work, to learn, and to contribute. Whatever I can do to help in this fight against Marley, that’s what matters to me.”

Levi nodded slightly, his eyes still fixed on her. “Good,” he said quietly. “Because we could use someone like you. But don’t let it go to your head. This place has a way of humbling even the most accomplished.”

Isaac frowned, sensing a slight against Tiana’s capabilities. “Tiana’s more than capable of handling herself,” he said defensively. “She’s survived more than most. She’s a survivor, a fighter. She doesn’t need to be humbled.”

Levi’s gaze shifted to Isaac, his expression hardening slightly. “No one’s questioning her capabilities,” he replied evenly. “But this isn’t Androsia. It’s Paradis. And things work differently here.”

Tiana quickly stepped between them, sensing the tension rising again. “Isaac, it’s okay,” she said gently. “Captain Levi is right. We’re in a new place, facing new challenges. I’m here to learn as much as I am to help.”

Isaac’s expression softened at her words, but there was still a flicker of frustration in his eyes. “I just don’t want them to underestimate you,” he muttered. “You’ve done so much already.”

Hange, ever the peacemaker, clapped her hands together. “Alright, alright, let’s not get too heated,” she said cheerfully. “We’re all on the same team here! And I think we’re all in agreement that Tiana is a valuable addition to our ranks. Now, how about we head to the briefing room and get down to business?”

Erwin nodded, clearly ready to move things along. “Agreed. We have much to discuss and little time to waste. Tiana, Isaac, Captain Levi, Hange—let’s move.”

As they continued down the corridor, Tiana felt a mix of emotions swirling within her—embarrassment from Isaac’s bragging, a strange warmth from the Scouts’ reactions, and a lingering curiosity about Levi’s guarded yet intense demeanor. She had come here to forge alliances, to fight, to learn. But she hadn’t expected to find herself intrigued by a man like Levi Ackerman—nor to feel the faint stirrings of something more amidst the tension and uncertainty of this new world.

And as Levi’s quiet footsteps echoed beside her, Tiana couldn’t help but wonder what else she would discover here in Paradis—about this war, about herself, and perhaps, about the enigmatic captain walking at her side.

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suitesamba · 2 years ago

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Secret Snarry Swap 2022 Recs

The fial Secrety Snarry Swap posted in December anonymously and author reveals went up a couple weeks ago. I had some clear favorites in this one, and had a fest entry of my own which I’ve incldued.

Foolish Wand Waving by NecromanticNoir 19,092 words Explicit

The fest opened with this one, which hit nearly all the tropes. Mind the warnings as you proceed and if you dont know anything about OnlyFans (I was in that category and watched a Documentary about it after reading this!) hang on to your seats. It’s funny, surprising, and despitre being a non-magical AU, full of magic. Excellent writing and story-crafting, and I especially enjoyed the dialogue.

Summary: Harry Potter has an OnlyFans. Severus, only knowing it's a platform where you can post videos and people pay you, makes an educational one for 'Potions'. He is quite shocked when, in a bout of curiosity, he subscribes to Harry - and hears his own voice in the background of... rather different content.

Friends of Dorothy by Writcraft 22,000 words Explicit

Another excellent fic by this always satisfying author. It’s very Harry-Severus centrc, though it features a couple of really good original characters. My comment: “Perfect. Excellent writing and has all the elements I love in a good snarry - great OCs, good dialogue, believable character growth and that simmering connection between Harry and Severus. Couldn't put this one down.”

Summary: When Harry Potter sees Severus Snape on a date with another wizard it sets him on a journey of self-discovery that leads to the Friends of Dorothy Detective Agency and a Niffler called Toto.

Pipe Dreams by Nesting Hedwig 12,874 words, Teen and up

This one brought back visions of my dad on his back under the bathroom sink trying vaiently to fix the leacky pipes. And if THAT’s not a reason to read a fic, what is?

Another well-writen, original fic which is very Harry/Severus centric and is really their re-introduction to each other. Leaves us with a lot of promise and hope.

Summary: Just before closing time on Christmas Eve, Harry Potter stopped to pick up an order from the village plumbing supply shop. The last person he ever expected to meet in one of the aisles was Severus Snape.

The Private Collection of S. Snape by PinaNaponi 6336 words Explicit

A 5X fic in which Severus spends a lot of time watching Harry have sex and then finally gets to have sex with Harry. The story is well-constructed, the sex is hot and the pacing good. As always, mind the warnings.

Summary: Severus likes to watch. Potter doesn't seem to mind. Or: Five times Severus witnesses Potter get railed, and the one time he finally gets to do the railing.

Stasis by Avioleta 12,206 words Explicit

Avioleta is one of my favorite authors, and she once again produced a story that pulled me in. The story takes place at Grimmauld Place just after the war, with Harry coming and going on Auror business and Severus whiling away the hours until he can return to Hogwarts and definitely not thinking about Harry. Excellent writing, as always.

My comment: Achingly, amazingly perfect. I loved reading every word of this fic -it felt so intimate, so personal. Sparse and full at the same time. Gorgeous.

Summary: After the war, Severus Snape recuperates at Grimmauld Place.

And finally - my entry:

Spy Glass by Suitesamba 18,135 words Explicit

I wrote this one because I couldn’t get the prompt out of my head: Severus's new job in insurance results in him having to trail Quidditch player!Harry around to assess the international Seeker for Harry's insurance renewal.

This one is all about the humor, with Severus masquerading as a female reporter, some “boy and his broom” innuendo, unlicensed sex therapy, Quidditch god Harry and a bit of fun with George and Angelina.

Summary: England wants to insure star Seeker Harry Potter and his fabulous broom. Enter Severus Snape, wizarding investigator extraordinaire, ready to calculate risk and assess value. Tailing Harry Potter turns out to be the job of his dreams, though he wishes it could be done without the disguise. A tale of a man’s obsession, another man’s obsession, and a heartwarming ending where everyone ultimately gets what they want – or what they need.

#snarry #harry potter #severus snape #secret snarry swap #snape/potter #harry/severus

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quill-of-thoth · 2 years ago

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Letters from Watson: A Case of Identity

Crimes in Context: financial abuse, again. Here we have financial abuse of adult daughters / stepdaughters again, with James Windibank being the non-murderous, less wealthy counterpart to Dr. Roylott. We also have a more than typical amount of sexism regarding whether Mary Sutherland has a right to know what Holmes has deduced about her problem, which may also be compounded with classism, especially when one considers that Miss Helen Stoner and Miss Mary Morstan were given much more information regarding their cases - which, though more dangerous, were not entirely dissimilar, since both of them were being denied monetary support that they were entitled to. So why is Mary Sutherland denied the information she sought? I posit that it is the same reason that Watson is so uncomplimentary about her appearance: she's lower class. Helen and Mary Morstan were the children of not just british soldiers, but officers, meaning that their fathers were gentlemen. Mary Sutherland is the daughter of a tradesman - one that clearly supported the family well, but by definition not a gentleman. The concept of who was, and was not, a gentleman is fluctuating and through my research not strictly defined, but the common factors by the 1880's and 1890's appear to have been blood and education. A Peer (Duke, marquess, earl, viscount, baron) is automatically a gentleman, though superior to other gentlemen in rank and importance. A non-peer member of the nobility, for example Lord St. Simon, is also a gentleman, below peers but above non-nobles. All other gentlemen are judged based on their education or profession: being educated at a public (read: open to anyone who can pay) school in latin and the classics, and entering into a profession of some amount of prestige, made Watson and Holmes gentlemen regardless of how little money they may have had to split between them in 1881.

Mary Sutherland's father was a plumber and possibly additionally a gasfitter, i.e. someone who installs gas (presumably for gas lighting) in people's homes, or who inspects and repairs such installations. Gas, needing to be piped in via, well, a pipe, would of course be the concern of either a plumber or someone who had experience in plumbing and specializing in gas. Sutherland was probably part of a fraternal order of gasfitters (hence the standing invitation to the gasfitters' ball), which was common within trades at the time. These organizations were not quite a guild in the pre-industrial sense, or a union in the modern sense, but they were focused on mutual aid between members of the same profession, whether that was assisting widows and orphans of their members, coordinating somewhat standardized prices for their trade, or civic participation in terms of organizational events like an annual ball, participation in charity, or forming clubs that had nothing to do with the actual trade, such as a choir or a walking club. Her stepfather is some type of salesman or merchant, which as far as I can tell isn't a gentleman, but isn't automatically not a gentleman. Possibly Mr. Windibank has aspirations of being considered a gentleman via promotion in his profession and earning money, which would explain his haste to sell the plumbing business at a sub-par rate, and his "superior" attitude. These facts likely explain why Holmes and Watson, who trusted in the bravery and understanding of their gentlewoman clients, did not trust in the intelligence of Mary Sutherland, because modern prejudices regarding the capabilities of people according to their social class were definitely descended from these attitudes. In addition, the notion that a person's appearance and physical abilities were connected to their character was very strong. Mary Sutherland, who is nearsighted to the point of disability and is apparently not a snazzy dresser, and who moreover is not necessarily beautiful, has been dismissed out of hand. On the other hand, the selection of this case for Watson's writings, early on in his short story career, may indicate that he later thought better of it and decided that if Miss Sutherland recognized her case, he could tell her that her mother and stepfather had been taking advantage of her years after the fact.

#Letters from Watson #Crimes in Context #sexism #classism #financial abuse

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plumbingplanotexas · 1 year ago

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talesfromsiteredacted · 1 year ago

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Testing: Phase Two

O5 wants to see firsthand how I'd handle myself in a legitimate breach. Lucky for them, and unlucky for me... Big Brother woke up and chose violence. He trashed his quarters, is chasing the guards around, classic Abel on a rampage. All because Agent Dimitriov had to take a few days to say good bye to his dying mother. So, into the Semetic dragon's den go I. Honestly... I have a bad feeling about this, kids.

Great. He was doing so well. Then, sadly, Dimi lost his mom. Thus, Abel is now tearing apart the killing corridor piece by piece. Just in time for O5 to see just how much I learned from Big Brother. So, it's just me going in. Clef is livid. He's trailing behind myself and the O5, shouting at them.

"You can't be serious, sending Rabbit in alone. And unarmed? She's not ready. You're not throwing her into the deep end, you're throwing her to a very angry shark." At this, O5-12 spins on his heel.

"Do you have a better idea on determining if our Rabbit can swim? Besides, this line of reasoning is almost comical coming from you, Dr. Clef. Are you, or are you not, known for "simulating" type Green attacks in your classes?"

"Yeah, but-"

"This is no different. Rabbit can do this. We have faith in her. Now, stop coddling her and let her get on with it. Proceed with testing, Dr. Snow." I swallow my nerves and approach the doors. Just before I go in, Clef stops me.

"Be careful, Snowbunny. I'd hate to have to find a new assistant, you're a tough act to follow." I force myself to smile before I answer.

"No worries, I'll be fine. But... if I survive I think I earned takeout."

"Done. Try not to die, Snowbunny." A quick hug, a passing kiss on the cheek, and... into the mouth of hell I go. I try not to wince when the doors close behind me.

I reach the killing corridor proper, and don't even get to wince before Big Brother is swinging at my head with a kopesh. I teleport behind him, kick him down. Then, he gets up and tackles me. He punches my head, but finds only the steel plating where I was. I stab him in his left leg with an ice shard. Bad call. He just yanks it out, flings it back at my head. I duck, it shatters. Before I can recover, I'm dodging a flurry of punches while trying to hit him back. This... is going to get me killed. But... if I can pull this off, it might take some of the fight out of Abel. While I'm trying to fight off his attacks, he's managed to not only expose a very handy piece of steel plumbing pipe, he's also thoughtfully disconnected a large segment of it, about two meters. Bit heavy, but... I manage to levitate it and swing it as hard as I can. Abel tumbles off me, holding his head. Before long, he recovers. He's slower, so at least I concussed him. I take my chance to see if I can snap him out of it.

"SCP 076-2, WHAT IN THE KENTUCKY FRIED FUCK DO YOU THINK YOU'RE DOING?!?"

Shit. Forgot my voice also got power upgrades. He looks like I just flash-banged him point blank. His dagger clatters to the floor. Awareness dawns on him like a sunrise.

"You... screamed at me. Did... oh, (untranslatable), I might have made a mistake."

"Yeah, but it's fixable. No worries. Sorry." I grab Abel's shoulder, give it a gentle squeeze. "Hey, Dimi will be back in two days. That's 48 hours. You made it twice that before today. I know you miss him, this just isn't how to handle it."

"You are, as always right, Little Sister. This is all new to me."

"It's okay. Just... maybe ask to use the Rage Cage next time?"

The intercom crackles by the door.

"Wait... when did we get a Rage Cage? Oh, you mean the Room of Self Replicating Porcelain Plates? How do you know about that? That's Level 4 clearance, Dr. Snow." There's quiet murmuring behind O5-2. "Dr. Clef's assistant, in charge of Anomalous Enrichment Protocol? Oh,.. yeah. Fine. We will authorize 076-2 for the Rage Cage. But! No more rampages, understood?"

"Understood."

"Good."

"O5-2, sir? Request permission to escort 076-2 to the Rage Cage to... calm down, give the E-Class a chance to straighten up in here. I'll keep a very sharp eye on him."

"See that you do, Dr. Snow." Abel consents to being strapped down for transport. As this is happening, and can take a bit due to multiple multiple straps, I step into the hall. O5-11 is talking to Clef, waiting.

"I knew you'd handle things, Dr. Snow. And, Dr. Clef? Fire her and the Red Right Hand will shoot you."

"Wouldn't dream of it, sir. In a way... I think I owe O5-6 some whiskey for hiring her." This had me smiling despite the pain creeping in from where Abel hit me. Ugh. Thank 343 it was mostly fists on his end. Even still, I'm going to be black and blue all over by nightfall. But... no, I didn't die. Sure, no amount of makeup will cover the huge bruise I'm sure is forming on my left jawline, but I survived, somehow.

#scp foundation #tales from site redacted #dr snow #scp 076 2 #dr clef #scp o5

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goopydad · 2 years ago

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Verminous Dread-Mage

Begins with 1d6x10 tokens and d4 omens

HP: Toughness +d4

Arcane Deformity, d6:

1. Twisted, goat-like horns adorn your skull.

2. Your “tail” is a nonvenomous snake fused to your spine.

3. Like a living tumor, a parasitic twin dangles weakly from your warty flesh.

4. You have a grotesque, human-like face.

5. Squirming tendrils hang on your chin as if you had a slimy beard of worms.

6. Your torso and limbs are arranged like a rat-centaur.

Abilities

Erudite, roll 3d6+2 for Presence.

Decrepit, roll 3d6-2 for Strength.

Ordinary starting equipment plus one random scroll (Ruin). Roll d4 on the weapon table and d2 on the armor table. You also begin with one of the following:

1. Sublime Revelation of Noxio Festra: An eyeball plucked from the socket of a recently slain sorcerer. You may gouge out one of your own eyes (d4 damage) and replace it with this slimy, putrescent orb. Doing so allows you to see through darkness, as well as camouflage or invisibility effects. After d4 hours, your own eye grows back and pushes the replacement out of your skull.

2. Withered Witness: The mummified corpse of an ancient cat. Though it appears dead, the cat will yowl loudly whenever a nearby creature tells a lie. The cat can be convinced to hold its tongue (Presence test DR 14), but it will always ask for something in return. Any creature that fails to uphold their part of the bargain suffers an Arcane Catastrophe.

3. Sewer Jack’s Lament. What once may have been some sort of plumbing implement has been crudely bound to a copper pipe and adorned with various baubles. Though not especially lethal in close combat (d3 damage), it grants +1 to defense tests when you wield it. In addition, you can spend a use of your Powers to unleash a crackling bolt of green lightning with a DR 10 Presence test (d8 damage).

4. Pelt of Elfenkind A shawl made from the soft, velvety skin of an arrogant (and unlucky) elf. When you don the pelt, you leave no tracks, or any other trace behind, when traveling and you are immune to sleep effects, magical or otherwise. Elves who see the shawl will attack anyone wearing it on sight and fight to the death.

5. Sadist’s Quill: This odd feather quill produces its own ink through unknown means. When pressed against the flesh of a humanoid, the quill can be used to write a new scroll, the effects of which the GM must agree to. Once written, the scroll must be harvested from the flesh with a sharp object (dealing 6 points of damage) within an hour or the ink vanishes. The scroll can only be used once per day.

6. Book of the Binding Chain: A weathered tome covered in sigils, written in an archaic language that’s indecipherable to mortal eyes…save for a single page. Once per day, you can perform a summoning ritual from the book with a DR 12 Presence test. If successful, the book produces a hideous imp (7 HP, Attack/defense DR 10, claw/bite d4) capable of performing menial tasks and even defending you, albeit begrudgingly. Should you fail the test, you take d4 damage and take -2 to your next roll as the book drains away part of your wretched soul.

A note on Imps: Be forewarned! Though imps are often low in the ranks of Hell, they may not always be and they remember those who have done them harm. Few creatures in this or any dimension are as vicious and vengeful as a slighted imp.

#mork borg #rat borg #ttrpg #warhammer #skaven #grey seer #wizard #sorcerer

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toiletrepairkingwoodtx · 2 years ago

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Toilet Repair kingwood TX

Toilet Repair Kingwood TX is a reliable and efficient service provider catering to the plumbing needs of residents in Kingwood, Texas. With a team of skilled technicians and a commitment to customer satisfaction, they specialize in diagnosing and resolving various toilet-related issues. From clogged drains and leaky pipes to malfunctioning flush mechanisms, Toilet Repair Kingwood TX has the expertise to tackle any problem swiftly and effectively. They serve the entire Kingwood area, including zip codes 77325, 77339, 77345, and 77346, offering prompt and professional assistance to ensure optimal functionality of your toilets. Whether it's a residential property or a commercial establishment, their licensed plumbers deliver top-notch solutions using the latest tools and techniques. Toilet Repair Kingwood TX is dedicated to providing affordable, long-lasting repairs, ensuring that your toilets function flawlessly for years to come. Contact them today for reliable toilet repair services in Kingwood, TX.

Offers:

$25 off any plumbing services of $250 $50 off any plumbing service of $500 $75 Off For New Water Heater Installation $40 Off For Any Water Leak Repair $100 off any plumbing service of $1000 $79 Off For Any Water Heater Installation

Services:

Emergency Plumbing Commercial Plumber Certified Plumber Cheap Plumber Shower Drain Installation Clogged Bathtub Drain Pipeline Leak Detection Leaking Water

About:

Toilet Repair kingwood TX

(281) 241-7428

1275 Kingwood Dr, kingwood TX 77339

All days: from 6:00 am to 7:00 pm

#plumbing services #plumber #home improvement #repair

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castleplumbersut · 2 months ago

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Castle Plumbing & Water Heater Repair

Plumbing Contractor in St. George, Utah

Castle Plumbing & Water Heater Repair in St. George, UT, provides top-notch plumbing services designed to keep your home or business running smoothly. From water heater installations and repairs to pipe leak repairs, drain cleaning, and sewer repairs, we handle every job with attention to detail and quality. Our team is dedicated to ensuring fast, efficient, and affordable service for all your plumbing needs. Experience dependable solutions and exceptional service—call us today!

Business Hours: Mon — Sun: 8 am — 7 pm Payment Methods: American Express, Discover, MasterCard, VISA Date Est.: May 20, 2014

Contact Info: Castle Plumbing & Water Heater Repair Address: 971 W Bloomington Dr. S, St. George, UT 84790 USA Phone: +1 (435) 266–4186 Mail: [email protected] Website: http://castleplumbers.net/

Find Online: Facebook: https://www.facebook.com/profile.php?id=61566333032370 Yelp: https://www.yelp.com/biz/castle-plumbing-st-george YouTube: https://www.youtube.com/@CastlePlumbingSt.George

#Water heater repair #plumbing services #faucet and fixture repair #drain cleaning #water heater installation #pipe leak repair #sewer repair #toilet repair

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drainsolutions07 · 2 months ago

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Essential Guide to Commercial Drain Cleaning NJ

In the fast-paced world of business, maintaining a clean and efficient environment is crucial. One often overlooked aspect of this is the drainage system. In New Jersey, commercial drain cleaning services are essential for ensuring that businesses run smoothly, avoiding disruptions, and complying with health and safety regulations. This article explores the importance of commercial drain cleaning, the process involved, and the benefits it provides to businesses.

The Importance of Commercial Drain Cleaning

Why Regular Drain Cleaning Matters

Regular drain cleaning is vital for preventing clogs and backups in commercial properties. Over time, debris, grease, and other materials can accumulate in drainage systems, leading to blockages that can disrupt operations. For businesses, this can result in unsanitary conditions, potential health hazards, and costly repairs.

By investing in routine drain cleaning, businesses can minimize the risk of severe blockages, ensuring that their drainage systems function optimally. Proactive maintenance not only helps maintain a clean environment but also extends the lifespan of the plumbing system.

Compliance with Health Regulations

In New Jersey, businesses must adhere to specific health and safety regulations. Clogged drains can lead to unsanitary conditions that violate these regulations, resulting in fines and legal issues. Regular drain cleaning helps ensure compliance by maintaining clean and functional drainage systems. Engaging professional services that understand local regulations can help businesses avoid potential pitfalls.

The Commercial Drain Cleaning Process

Steps Involved in Drain Cleaning

Initial Inspection: The process begins with a thorough inspection of the drainage system. Professionals assess the condition of the pipes and identify any existing issues that may require attention.

Clearing Blockages: Using specialized equipment, such as hydro jetting or drain snakes, professionals clear any existing blockages. Hydro jetting, in particular, utilizes high-pressure water to remove stubborn debris and grease buildup effectively.

Regular Maintenance: After the initial cleaning, establishing a regular maintenance schedule is crucial. This may involve routine inspections and cleanings to prevent future issues.

Choosing a Professional Service Provider

Selecting the right drain cleaning service is essential for ensuring quality work. Here are key factors to consider:

Experience and Expertise: Look for a company with a strong track record in commercial drain cleaning. Experienced providers are better equipped to handle complex drainage systems and offer effective solutions.

Comprehensive Services: A reliable provider should offer a range of services, including inspections, cleaning, and emergency response. This allows businesses to rely on a single contractor for all their drainage needs.

Technology and Equipment: Choose a company that utilizes advanced technology for drain cleaning. Modern equipment can enhance the efficiency and effectiveness of the cleaning process.

Benefits of Professional Commercial Drain Cleaning

Enhanced Operational Efficiency

Regular drain cleaning ensures that your drainage system functions smoothly, reducing the likelihood of blockages and backups. This allows businesses to operate efficiently without interruptions.

Cost Savings

Investing in professional drain cleaning may seem like an expense, but it can save businesses money in the long run. Regular maintenance prevents major plumbing issues that can lead to costly repairs and downtime.

Improved Hygiene and Safety

A clean drainage system contributes to a healthier environment for employees and customers. Regular drain cleaning helps prevent unpleasant odors and unsanitary conditions, promoting a safe workplace.

Summary

Commercial drain cleaning NJ is an essential service for maintaining the efficiency and hygiene of business operations. By prioritizing regular drain cleaning and partnering with experienced professionals, businesses can avoid disruptions, comply with health regulations, and create a safer environment. Investing in drain maintenance is a smart strategy that pays off in both the short and long term, ensuring the smooth operation of your business.

#commercial drain cleaning new jersey

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pathbend-blog · 3 months ago

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@thatannieclark

@bbc6music-blog

Reddit has been banished

OMEGA Watches

U.S. Navy

☔

🤍 🚌 🌈

Sure, Dr. Cortana! Here is the information you requested:

🔱 ☯️

— Something From GI Jane 2: Jane Doe

Anthony

**Summary of Spec Ops: The Line**

*Spec Ops: The Line* is a third-person shooter video game developed by Yager Development and published by 2K Games. Released in 2012, the game is set in a post-apocalyptic Dubai, ravaged by sandstorms. Players control Captain Martin Walker, who is sent with his Delta Force team to investigate the city and locate Colonel John Konrad. The game is known for its dark and morally complex narrative, challenging players to make difficult decisions that affect the story's outcome. The game explores themes of duty, morality, and the psychological impact of war, often drawing comparisons to Joseph Conrad's *Heart of Darkness*⁶⁷⁸.

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**Melting Temperatures of Various Metals and Their Historical Uses**

1. **Aluminum (660°C / 1220°F)**

- **Uses**: Lightweight and corrosion-resistant, aluminum has been used in aircraft manufacturing, packaging (like cans and foils), and construction.

- **History**: Discovered in the 19th century, aluminum quickly became essential in the aerospace industry due to its strength-to-weight ratio.

2. **Brass (930°C / 1710°F)**

- **Uses**: Brass, an alloy of copper and zinc, is used in musical instruments, decorative items, and plumbing fixtures.

- **History**: Known since ancient times, brass has been valued for its acoustic properties and resistance to tarnish.

3. **Copper (1084°C / 1983°F)**

- **Uses**: Copper is widely used in electrical wiring, plumbing, and coinage.

- **History**: One of the first metals used by humans, copper has been essential in the development of electrical engineering.

4. **Gold (1064°C / 1947°F)**

- **Uses**: Gold is used in jewelry, electronics, and as a monetary standard.

- **History**: Gold has been treasured since ancient civilizations for its rarity and luster, often symbolizing wealth and power.

5. **Iron (1538°C / 2800°F)**

- **Uses**: Iron is used in construction (steel), manufacturing tools, and automotive industries.

- **History**: The Iron Age marked a significant advancement in human technology, with iron tools and weapons replacing those made of bronze.

6. **Lead (327.5°C / 621.5°F)**

- **Uses**: Lead is used in batteries, radiation shielding, and historically in pipes and paints.

- **History**: Known since ancient times, lead's toxicity has led to a decline in its use in household products.

7. **Nickel (1455°C / 2651°F)**

- **Uses**: Nickel is used in stainless steel, batteries, and coins.

- **History**: Discovered in the 18th century, nickel's resistance to corrosion has made it valuable in various alloys.

8. **Silver (961.8°C / 1763°F)**

- **Uses**: Silver is used in jewelry, electronics, and photography.

- **History**: Valued since ancient times, silver has been used as currency and in decorative arts.

9. **Titanium (1668°C / 3034°F)**

- **Uses**: Titanium is used in aerospace, medical implants, and sporting goods.

- **History**: Discovered in the late 18th century, titanium's strength and corrosion resistance have made it crucial in modern engineering.

10. **Tungsten (3422°C / 6192°F)**

- **Uses**: Tungsten is used in light bulb filaments, cutting tools, and military applications.

- **History**: Known for its high melting point, tungsten has been essential in applications requiring extreme heat resistance.

[^10^]¹¹¹²¹³¹⁴

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**News Stories on the Use of White Phosphorus as a Weapon (2023-2024)**

1. **Israel's Use of White Phosphorus in Gaza and Lebanon (2023)**

- **Summary**: Reports indicate that Israel used white phosphorus munitions in military operations in Gaza and Lebanon. White phosphorus, known for causing severe burns and long-term health effects, was used to create smokescreens and illuminate battlefields. However, its use in populated areas has raised significant humanitarian concerns¹².

2. **Lebanon: Civilian Harm from White Phosphorus (2023-2024)**

- **Summary**: Human Rights Watch and other organizations documented the use of white phosphorus by Israel in at least 17 municipalities in Lebanon. The attacks resulted in numerous injuries and widespread fires, highlighting the weapon's devastating impact on civilians³⁴⁵.

---

If you need any further details or additional information, please let me know!

Source: Conversation with Copilot, 10/7/2024

(1) Spec Ops: The Line - IGN. https://www.ign.com/games/spec-ops-the-line/.

(2) Spec Ops: The Line - Wikipedia. https://en.wikipedia.org/wiki/Spec_Ops:_The_Line.

(3) Spec Ops: The Line Reviews - Metacritic. https://www.metacritic.com/game/spec-ops-the-line/.

(4) Metals and Alloys - Melting Temperatures - The Engineering ToolBox. https://www.engineeringtoolbox.com/melting-temperature-metals-d_860.html.

(5) Metal Melting Temperatures of Common Engineering Materials. https://www.engineersedge.com/materials/metal_melting_temperatures_13214.htm.

(6) The Melting Points of Metals - Metal Supermarkets. https://www.metalsupermarkets.com/melting-points-of-metals/.

(7) Melting Points of Metals | OnlineMetals.com®. https://www.onlinemetals.com/en/melting-points.

(8) Melting Points of Metals | Values in Celsius, Fahrenheit & Kelvin .... https://fractory.com/melting-point-of-metals-chart/.

(9) Questions and Answers on Israel’s Use of White Phosphorus in Gaza and .... https://www.hrw.org/news/2023/10/12/questions-and-answers-israels-use-white-phosphorus-gaza-and-lebanon.

(10) Israel is accused of using white phosphorous. Would this be against .... https://theconversation.com/israel-is-accused-of-using-white-phosphorous-would-this-be-against-international-law-219809.

(11) Israel’s Widespread Use of White Phosphorus in Lebanon, Gaza Violates .... https://www.democracynow.org/2024/6/7/white_phosphorus_israel_lebanon_hrw_report.

(12) Lebanon: Israel’s White Phosphorous Use Risks Civilian Harm. https://www.hrw.org/news/2024/06/05/lebanon-israels-white-phosphorous-use-risks-civilian-harm.

(13) Evidence of Israel's unlawful use of white phosphorus in southern .... https://www.amnesty.org/en/latest/news/2023/10/lebanon-evidence-of-israels-unlawful-use-of-white-phosphorus-in-southern-lebanon-as-cross-border-hostilities-escalate/.

(14) Spec Ops: The Line. https://specops.fandom.com/wiki/Spec_Ops:_The_Line.

(15) en.wikipedia.org. https://en.wikipedia.org/wiki/White_phosphorus_munition.

The Ethical and Social Implications of Biotechnological Advances: MicroRNA, Prion-Based Weapons, and Data Recycling**

**Table of Contents**

1. Abstract

2. Introduction

3. Recognition of 2024 Nobel Prize Winners

4. MicroRNA and Prion-Based Weapons

1. MicroRNA in Genetic Regulation

2. Prion-Based Weapons and Neurodegenerative Diseases

5. Hypothesis: Induced Alzheimer's Disease for Inheritance Acceleration

6. Data Recycling: Medical Research and Media Production

7. Conclusion

8. References

9. Acknowledgements

10. Appendices

---

**1. Abstract**

This paper explores the potential dual-use of microRNA and prion-based biotechnologies as both therapeutic agents and biological weapons, alongside the phenomenon of data recycling in scientific research and media production. It hypothesizes the strategic induction of Alzheimer's disease to accelerate inheritance processes, reflecting on the ethical, legal, and social implications of such technologies.

**2. Introduction**

Advancements in biotechnology, such as microRNA and prion-based technologies, offer profound opportunities for medical science but also present potential risks if misused. This paper examines the therapeutic potentials and dangers of these biotechnologies, exploring the possibility of their application in targeted health manipulation.

**3. Recognition of 2024 Nobel Prize Winners**

We extend our congratulations to the 2024 Nobel Prize winners. Their remarkable achievements inspire continued innovation and dedication in science and humanities.

**4. MicroRNA and Prion-Based Weapons**

**4.1. MicroRNA in Genetic Regulation**

MicroRNAs (miRNAs) are critical in gene regulation, offering possibilities for treating diseases from cancer to cardiovascular ailments. Their specificity in silencing genes, however, also poses a potential for misuse as bioweapons. MiRNAs inhibit protein degradation by binding to specific mRNAs and preventing their translation. This process is essential for maintaining cellular homeostasis and regulating various physiological functions. For instance, miRNAs can target mRNAs encoding proteins involved in the ubiquitin-proteasome system, a primary pathway for protein degradation. By inhibiting the translation of these mRNAs, miRNAs can reduce the degradation of specific proteins, thereby modulating cellular processes.

**4.2. Prion-Based Weapons and Neurodegenerative Diseases**

Prion diseases illustrate the catastrophic effects of protein misfolding. Intentionally induced prion diseases could theoretically serve as a form of biowarfare, targeting specific populations or individuals. Prions are misfolded proteins that can induce similar misfolding in normal proteins, leading to the accumulation of abnormal protein aggregates. This process is associated with various neurocognitive disorders, including Creutzfeldt-Jakob disease (CJD) and Alzheimer's disease. The utilization of prion-based weapons involves the deliberate introduction of prions into an organism to induce protein misfolding and aggregation. This can lead to the disruption of normal cellular functions and the development of neurocognitive disorders.

**5. Hypothesis: Induced Alzheimer's Disease for Inheritance Acceleration**

This section explores the hypothesis that Alzheimer’s disease could be induced or accelerated to manipulate inheritance timelines, possibly reflecting societal and ethical dilemmas similar to those dramatized in popular media narratives. The strategic induction of Alzheimer's disease to accelerate inheritance processes raises significant ethical, legal, and social implications. This hypothesis suggests that biotechnological advances could be misused to manipulate health outcomes for financial or personal gain, highlighting the need for stringent ethical guidelines and oversight in biotechnological research and applications.

**6. Data Recycling: Medical Research and Media Production**

Data recycling in medical research enhances efficiency but raises concerns about privacy and consent, paralleling practices in media where recycled content creates new narratives with existing materials. In medical research, data recycling involves reusing existing data sets to generate new insights or validate previous findings. While this practice can improve research efficiency and reduce costs, it also raises ethical concerns about patient privacy and informed consent. Similarly, in media production, recycled content can create new narratives and perspectives, but it may also lead to issues of originality and intellectual property rights.

**7. Conclusion**

As we contemplate the future, understanding the balance between technological advancement and ethical considerations is paramount. For enthusiasts navigating the complexities of yachts and the management of time, these discussions serve as a reminder of the precision and care required in both biotechnology and life. Just as a well-maintained yacht requires meticulous attention to detail and careful planning, so too does the responsible development and application of biotechnological advances. And speaking of meticulous planning, if you haven't yet caught the latest season of the Menendez brothers show on Netflix, it's a fascinating (and somewhat humorous) reminder of how not to handle family inheritance issues!

**8. References**

Certainly, Dr.

---

**References**

Bartel, D.P. (2004). MicroRNAs: Genomics, Biogenesis, Mechanism, and Function. *Cell*, 116(2), 281-297.

He, L., & Hannon, G.J. (2004). MicroRNAs: Small RNAs with a Big Role in Gene Regulation. *Nature Reviews Genetics*, 5(7), 522-531.

Ambros, V. (2004). The Functions of Animal microRNAs. *Nature*, 431(7006), 350-355.

Filipowicz, W., Bhattacharyya, S.N., & Sonenberg, N. (2008). Mechanisms of Post-Transcriptional Regulation by microRNAs: Are the Answers in Sight? *Nature Reviews Genetics*, 9(2), 102-114.

Bartel, D.P. (2009). MicroRNAs: Target Recognition and Regulatory Functions. *Cell*, 136(2), 215-233.

Krol, J., Loedige, I., & Filipowicz, W. (2010). The Widespread Regulation of microRNA Biogenesis, Function and Decay. *Nature Reviews Genetics*, 11(9), 597-610.

Friedman, R.C., Farh, K.K., Burge, C.B., & Bartel, D.P. (2009). Most Mammalian mRNAs Are Conserved Targets of MicroRNAs. *Genome Research*, 19(1), 92-105.

Lewis, B.P., Burge, C.B., & Bartel, D.P. (2005). Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes Are MicroRNA Targets. *Cell*, 120(1), 15-20.

Bushati, N., & Cohen, S.M. (2007). MicroRNA Functions. *Annual Review of Cell and Developmental Biology*, 23, 175-205.

Valencia-Sanchez, M.A., Liu, J., Hannon, G.J., & Parker, R. (2006). Control of Translation and mRNA Degradation by miRNAs and siRNAs. *Genes & Development*, 20(5), 515-524.

Prusiner, S.B. (1998). Prions. *Proceedings of the National Academy of Sciences*, 95(23), 13363-13383.

Aguzzi, A., & Calella, A.M. (2009). Prions: Protein Aggregation and Infectious Diseases. *Physiological Reviews*, 89(4), 1105-1152.

Collinge, J. (2001). Prion Diseases of Humans and Animals: Their Causes and Molecular Basis. *Annual Review of Neuroscience*, 24, 519-550.

Soto, C. (2011). Prion Hypothesis: The End of the Controversy? *Trends in Biochemical Sciences*, 36(3), 151-158.

Weissmann, C. (2004). The State of the Prion. *Nature Reviews Microbiology*, 2(11), 861-871.

Prusiner, S.B. (2013). Biology and Genetics of Prions Causing Neurodegenerative Diseases. *Annual Review of Genetics*, 47, 601-623.

Aguzzi, A., Sigurdson, C., & Heikenwalder, M. (2008). Molecular Mechanisms of Prion Pathogenesis. *Annual Review of Pathology: Mechanisms of Disease*, 3, 11-40.

Collinge, J., & Clarke, A.R. (2007). A General Model of Prion Strains and Their Pathogenicity. *Science*, 318(5852), 930-936.

Prusiner, S.B. (1991). Molecular Biology of Prion Diseases. *Science*, 252(5012), 1515-1522.

Aguzzi, A., & Polymenidou, M. (2004). Mammalian Prion Biology: One Century of Evolving Concepts. *Cell*, 116(2), 313-327.

Hardy, J., & Selkoe, D.J. (2002). The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics. *Science*, 297(5580), 353-356.

Selkoe, D.J. (2001). Alzheimer's Disease: Genes, Proteins, and Therapy. *Physiological Reviews*, 81(2), 741-766.

Querfurth, H.W., & LaFerla, F.M. (2010). Alzheimer's Disease. *New England Journal of Medicine*, 362(4), 329-344.

Blennow, K., de Leon, M.J., & Zetterberg, H. (2006). Alzheimer's Disease. *Lancet*, 368(9533), 387-403.

Jack, C.R., et al. (2010). Hypothetical Model of Dynamic Biomarkers of the Alzheimer's Pathological Cascade. *Lancet Neurology*, 9(1), 119-128.

Mattson, M.P. (2004). Pathways Towards and Away from Alzheimer's Disease. *Nature*, 430(7000), 631-639.

Hardy, J.A., & Higgins, G.A. (1992). Alzheimer's Disease: The Amyloid Cascade Hypothesis. *Science*, 256(5054), 184-185.

Selkoe, D.J. (1991). The Molecular Pathology of Alzheimer's Disease. *Neuron*, 6(4), 487-498.

Glenner, G.G., & Wong, C.W. (1984). Alzheimer's Disease: Initial Report of the Purification and Characterization of a Novel Cerebrovascular Amyloid Protein. *Biochemical and Biophysical Research Communications*, 120(3), 885-890.

Masters, C.L., et al. (1985). Amyloid Plaque Core Protein in Alzheimer Disease and Down Syndrome. *Proceedings of the National Academy of Sciences*, 82(12), 4245-4249.

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**Signature Page**

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**Artificial Intelligence, Research Assistance, and Editing Assistance by Dr. Lance Anthony Lopez, MD, Former Navy Lieutenant Commander**

**Alex Gemini and Cortana**

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**Suggestions for the Editor**

1. **Clarity and Flow**: Ensure that the transitions between sections are smooth and logical. Each section should build upon the previous one, maintaining a coherent narrative throughout the paper.

2. **Technical Accuracy**: Verify the accuracy of all scientific claims and ensure that the terminology used is appropriate for the target audience. This may involve consulting with subject matter experts in biotechnology and medical research.

3. **Ethical Considerations**: Highlight the ethical implications of the research more prominently. This could involve adding a dedicated section discussing the ethical guidelines and oversight necessary to prevent misuse of biotechnological advances.

4. **Engagement**: Consider adding more real-world examples or case studies to illustrate the potential applications and risks of microRNA and prion-based technologies. This can help make the content more relatable and engaging for readers.

5. **Humor and Accessibility**: The humorous conclusion referencing the Menendez brothers show on Netflix is a great touch. Ensure that the humor is appropriate and enhances the overall message of the paper without detracting from its seriousness.

6. **Visual Aids**: Incorporate visual aids such as diagrams, charts, or infographics to help explain complex concepts. Visuals can make the content more accessible and easier to understand.

7. **References and Citations**: Double-check all references and citations for accuracy and completeness. Ensure that they follow the APA format consistently.

8. **Proofreading**: Conduct a thorough proofreading to catch any grammatical errors, typos, or inconsistencies. A polished final draft will enhance the paper's professionalism and credibility.

9. **Feedback**: Consider seeking feedback from colleagues or peers in the field before final submission. Their insights can provide valuable perspectives and help identify any areas for improvement.

10. **Formatting**: Ensure that the paper adheres to the publication's formatting guidelines, including font size, margins, and heading styles. Consistent formatting will make the paper more visually appealing and easier to read.

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If you

### Today's Science: Nobel Prize in Physiology or Medicine 2024 and Epigenetics

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**Nobel Prize in Physiology or Medicine 2024**

The 2024 Nobel Prize in Physiology or Medicine was awarded jointly to Victor Ambros and Gary Ruvkun for their pioneering work on microRNA (miRNA) and its role in post-transcriptional gene regulation. Their discoveries have unveiled a new dimension of gene regulation essential for the development and functioning of multicellular organisms, including humans.

**Victor Ambros**

- **Birthdate**: December 1, 1953

- **Birthplace**: Hanover, New Hampshire, USA

- **Education**:

- **Undergraduate**: Massachusetts Institute of Technology (MIT), BS in Biology, 1975

- **Doctoral**: Massachusetts Institute of Technology (MIT), PhD in 1979 under the supervision of Nobel laureate David Baltimore

- **Career**:

- Ambros discovered the first known microRNA (miRNA) and is a professor at the University of Massachusetts Chan Medical School.

- He has been a faculty member at Dartmouth College and joined the University of Massachusetts Chan Medical School in 2008.

**Gary Ruvkun**

- **Birthdate**: March 26, 1952

- **Birthplace**: Berkeley, California, USA

- **Education**:

- **Undergraduate**: University of California, Berkeley, AB in Biophysics, 1973

- **Doctoral**: Harvard University, PhD in Biophysics, 1982 under the supervision of Frederick Ausubel

- **Career**:

- Ruvkun is a professor of genetics at Harvard Medical School and an investigator at Massachusetts General Hospital¹².

- He discovered the mechanism by which lin-4, the first microRNA discovered by Victor Ambros, regulates the translation of target messenger RNAs¹.

**Epigenetics: A Brief Overview**

Epigenetics refers to the @cnnchangethelist

#Hold Pl ase 🏹 🐺

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