#dolutegravir

[gecenin-karanligi-21]

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[pharmaceutical0]

Dolutegravir

Simson Pharma provides best quality Dolutegravir.

Every compound produced by Simson Pharma is accompanied by Certificate of Analysis.

https://www.simsonpharma.com/product/dolutegravir

[russianreader]

HIV Is on the Rise Again in Russia

The number of new cases of HIV infection in Russia has been growing again. In 2022, 63,150 people were diagnosed with HIV, while a year earlier this figure was 61,098 people, according to the Russian Health Ministry. During the pandemic, fewer cases of HIV infection were detected in Russia due to reduced testing coverage and lockdowns. The HIV detection rate in Russia increased by eight percent…

[daisydeborahh]

THE DOLUTEGRAVIR OPPORTUNITY

DTG is a relatively new ARV available in generic form in low- and middle-income countries. It is an integrase inhibitor that blocks an HIV enzyme (a protein that starts or increases the speed of a chemical reaction) called integrase. By blocking integrase, integrase inhibitors prevent HIV from multiplying and can reduce the amount of HIV in the body. As a single dose, in conjunction with other drugs to form a regimen, 50mg DTG single has been on the market in developing countries for a couple of years. However, its relatively high price and unavailability in a triple fixed-dose form limited significant uptake. Botswana, however, was an early adopter of the DTG single through a special initiative of the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR).

In August 2017, the US Food and Drug Administration (FDA) provided tentative approval for two Indian generic ARV suppliers – Aurobindo Pharma and Mylan Laboratories Limited – for the fixed-dose combination of tenofovir 300mg /lamivudine 300mg /dolutegravir 50mg (TLD), reducing one barrier for adoption in developing countries.

[daisydeborahh]

Clinical Commissioning Policy: Dolutegravir for treatment of HIV-1 infection (all ages)

HIV treatment has improved greatly over the last two decades and standard of care now involves triple therapy, typically with two nucleos(t)ide reverse transcriptase inhibitors (NRTIs) plus one of the following: a ritonavir-boosted protease inhibitor (PI/r), a non nucleoside reverse transcriptase inhibitor (NNRTI) or an integrase inhibitor.

Effective antiretroviral treatment (ART) requires high adherence to drug regimes. Development of new ARV medicines often focuses on improvements in tolerability, reductions in toxicity and drug to drug interactions.

Effectiveness of ART is measured by an undetectable viral load. The proportion of treated individuals with a viral load less than 50 has improved (94% in 2016) which may be driven, at least in part, by improvements in drug choice. Current standard treatment is therefore effective for many people. The availability of generic ART has reduced the cost of standard treatment considerably. New drug treatments need to demonstrate both clinical and cost effectiveness over standard treatments.

[daisydeborahh]

Dolutegravir for the treatment of pregnant women living with HIV

HIV, which stands for Human Immunodeficiency Virus, is a retrovirus that causes AIDS (Acquired Immune Deficiency Syndrome). In 2018, a total of 4,026 pregnant women living with HIV were identified, with the indication to start antiretroviral therapy (ART). The timely initiation of ART, with improved adherence and tolerability, is critical for achieving an undetectable viral load, and, consequently, preventing vertical transmission (VT) of HIV.