#daidzein market

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Soy Isoflavones Market: Key Players and Strategies from 2023 to 2030

The global soy isoflavones market is expected to grow from US$ 1.49 billion in 2023 to US$ 2.41 billion by 2030, at a CAGR of 6.16% during the forecast period. It is true that isoflavones are organic compounds, mostly present in different types of beans. Soybeans and products made from them are incredibly rich sources of isoflavones because they are the physiologically active components of soybeans, or isoflavones.

These chemicals, which are often referred to as phytoestrogens, work similarly to the female hormone estrogen. Because of this property, soy isoflavones are an active ingredient in many products that support the health of women. The two primary isoflavones found in soy are daidzein and genistein.

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Drivers For Soy Isoflavones In The Market:

The strong and increasing demand for soy isoflavones from post-menstrual women drives the market. This need arises from the fact that women at this age have a marked decrease in estrogen, leading to various problems such as hot flashes, excessive perspiration, and weight gain.

Two serious issues that decreased estrogen levels may cause are osteoporosis and heart difficulties. Compared to operations such as hormone replacement therapy, soy isoflavones provide less risk to the health of the user.

Key Takeaways:

The global soy isoflavones market is expected to grow from US$ 1.49 billion in 2023 to US$ 2.41 billion by 2030, at a CAGR of 6.16% during the forecast period.

The market growth is attributed to the increasing awareness of the health benefits of soy isoflavones, rising demand for soy-based food and beverages, and growing application of soy isoflavones in the pharmaceutical and nutraceutical industries.

North America is expected to remain the largest market for soy isoflavones, followed by Asia Pacific and Europe.

Regional Outlook and Analysis:

North America is expected to remain the largest market for soy isoflavones, owing to the increasing awareness of the health benefits of soy isoflavones and the growing demand for soy-based food and beverages.

Asia Pacific is expected to grow at the fastest CAGR during the forecast period, owing to the rising disposable incomes and increasing awareness of the health benefits of soy isoflavones.

Europe is expected to witness significant growth in the soy isoflavones market, owing to the increasing demand for soy-based food and beverages and the growing application of soy isoflavones in the pharmaceutical and nutraceutical industries.

Key Players:

ADM

Solbar Industries

Alpro

Frutarom

Shengyuan

FutureCeuticals

Fujicco

Soy Isoflavones Market segmentation by category:

By Raw-material type:

Genetically Modified (GM)

Non-Genetically Modified (Non-GM) Soy

By The Application:

Soy-Beverages

Functional Foods

Healthcare Products

Dietary

Menopausal

Bone Health

Others Supplements

By Product Type:

Genistein

Daidzein

Glutenin

By Region:

North America

Latin America

Europe

Asia Pacific

Oceania

Middle East and Africa

By Distribution Channel:

Pharmacies/Drugstores

Health & Beauty stores

Hypermarket/Supermarket

Direct Selling

Online

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Daidzein Market Research and Growth Analysis by Industry Size, Technology, Trends, Regional Share and Global Forecast to 2026.

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Global Daidzein  Market Analysis, Growth Rate, Demand, Size and Share - Present Scenario and Future Forecast To 2027

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Global Daidzein Market 2019 | Manufacturers In-Depth Analysis Report to 2024

The latest trending report Global Daidzein Market 2019-2024 added by DecisionDatabases.com

Daidzein is an isoflavonoid phytoestrogenic compound found in soybeans, pea pods, clover, kudzu, and other legumes. They can use in food field, health product field, cosmetics field, pharmaceutical field, etc. Soy is the major source of extracting Daidzein globally.

The worldwide market for Daidzein is expected to grow at a CAGR of roughly xx% over the next five years, will reach xx million US$ in 2024, from xx million US$ in 2019.

This report focuses on the Daidzein in global market, especially in North America, Europe and Asia-Pacific, South America, Middle East and Africa. This report categorizes the market based on manufacturers, regions, type and application.

Browse the complete report and table of contents @ https://www.decisiondatabases.com/ip/25929-daidzein-market-analysis-report

Market Segment by Manufacturers, this report covers

 ADM

 Frutarom Health

 Shaanxi Huike

 Xi’an Desheng yuan

 Jiangxi Shun Tiancheng

 Changzhou Longterm

 Shaanxi Green

 N&R Industries

Market Segment by Regions, regional analysis covers

 North America (United States, Canada and     Mexico)

 Europe (Germany, France, UK, Russia and     Italy)

 Asia-Pacific (China, Japan, Korea, India     and Southeast Asia)

 South America (Brazil, Argentina,     Colombia etc.)

 Middle East and Africa (Saudi Arabia,     UAE, Egypt, Nigeria and South Africa)

Market Segment by Type, covers

 Soybeans Source

 Chemical Synthesis

 Others

Market Segment by Applications, can be divided into

 Nutraceutical & Medicine

 Feed Additives

 Others Application

Download Free Sample Report of Global Daidzein Market @ https://www.decisiondatabases.com/contact/download-sample-25929

The content of the study subjects, includes a total of 15 chapters: Chapter 1, to describe Daidzein product scope, market overview, market opportunities, market driving force and market risks. Chapter 2, to profile the top manufacturers of Daidzein, with price, sales, revenue and global market share of Daidzein in 2017 and 2018. Chapter 3, the Daidzein competitive situation, sales, revenue and global market share of top manufacturers are analyzed emphatically by landscape contrast. Chapter 4, the Daidzein breakdown data are shown at the regional level, to show the sales, revenue and growth by regions, from 2014 to 2019. Chapter 5, 6, 7, 8 and 9, to break the sales data at the country level, with sales, revenue and market share for key countries in the world, from 2014 to 2019. Chapter 10 and 11, to segment the sales by type and application, with sales market share and growth rate by type, application, from 2014 to 2019. Chapter 12, Daidzein market forecast, by regions, type and application, with sales and revenue, from 2019 to 2024. Chapter 13, 14 and 15, to describe Daidzein sales channel, distributors, customers, research findings and conclusion, appendix and data source.

Purchase the complete Global Daidzein Market Research Report @ https://www.decisiondatabases.com/contact/buy-now-25929

Other Reports by DecisionDatabases.com:

Global Textured Soybean Protein Market 2019 by Manufacturers, Regions, Type and Application, Forecast to 2024 @ https://www.decisiondatabases.com/ip/27200-textured-soybean-protein-market-analysis-report

Global Red Clover Market 2018 by Manufacturers, Regions, Type and Application, Forecast to 2023 @ https://www.decisiondatabases.com/ip/36548-red-clover-market-analysis-report

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Our expert research analysts have been trained to map client’s research requirements to the correct research resource leading to a distinctive edge over its competitors. We provide intellectual, precise and meaningful data at a lightning speed.

For more details:                             DecisionDatabases.com E-Mail: sales@decisiondatabases.com Phone: +91 9028057900 Web: https://www.decisiondatabases.com/

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Daidzein Market Production, Trends, Price, Revenue, Share, Growth and Forecast Until 2026

Daidzein Market Production, Trends, Price, Revenue, Share, Growth and Forecast Until 2026

Global “Daidzein Market 2018” Industry Share, Growth, Research, Analysis, Development Trends, Demands, and Forecasts.

The Daidzein research report contains a professional analysis of the current state of the global Daidzein market and the factors that will shape its progression in the future. The Daidzein industry report also examines marked growth trends and technological developments that will…

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Soy Isoflavones Market - Forecast (2022 - 2027)

Soy Isoflavones Market size is estimated to reach $436.9 million by 2027, growing at a CAGR of 4.7% during the forecast period 2022-2027. Isoflavones are commonly delineated as phytostrogens as they are derived from plants and fall under the category of polyphenolic compounds and share estrogen-like structure and effect. Soy isoflavones are mined from bark, leaves, and other parts of the plant. Besides soybeans, other legumes crops such as peanuts, chickpeas, and red clover are rich sources of these polyphenolic compounds. Glycosides like genistin, glycitin, and daidzein are present in soybeans that make it of utmost importance in the prevention of many cardiovascular complications, osteoporosis, and hormone-dependent cancer. Over the year, clinical studies have proven that augmented consumption of such phytoestrogens supports the alteration of endogenous estrogen into protective 2-hydroxylated estrogens extends its helping hand in dropping breast proliferation stimulants, thereby, eventually, reducing the risks of breast cancer prevalence in women. The soy isoflavones market outlook is fairly impressive and is attributable to budding usage of isoflavones in dietary supplements pertaining to the antimicrobial and anticancer properties of isoflavones. Accruing prevalence of cancer, gastrointestinal infections, bone illnesses such as osteoporosis, diabetes, and cognitive impairment are factors set to drive the growth of the Soy Isoflavones Industry for the period 2022-2027.

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Report Coverage

The report: “Soy Isoflavones Market Forecast (2022-2027)”, by Industry ARC, covers an in-depth analysis of the following segments of the Soy Isoflavones Market.

By Form: Wax, Liquid, Capsules, and Powder. By Application: Pharmaceuticals (dietary supplements, medicines, and cosmetics), Food and beverages, Nutraceuticals. By Packaging: Blister packaging, Alu-Alu strip, HDPE bottles, Polybags, Stand-up pouches, and others. By Distribution Channel: Offline and Online Platforms. By Geography: North America (U.S., Canada, and Mexico), Europe (Germany, UK, France, Italy, Spain, Russia, and Rest of Europe), Asia-Pacific (China, India, Japan, South Korea, Australia & New Zealand, and Rest of Asia-Pacific), South America (Brazil, Argentina, and Rest of South America) and Rest of World (the Middle East and Africa).

Key Takeaways

Geographically, the Asia-Pacific Soy Isoflavones Market accounted for the highest revenue share in 2021 and it is poised to dominate the market over the period 2022-2027.

Expanding disposable income levels and mounting health cognizance among people is said to be preeminent driver driving the growth of the Soy Isoflavones Market. Unfavorable climate conditions owing to environmental challenges, adverse effects of overusing soya, and vulnerable manufacturing activities are said to reduce the market growth.

Detailed analysis on the Strength, Weaknesses, and Opportunities of the prominent players operating in the market will be provided in the Soy Isoflavones Market report.

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Soy Isoflavones Market Segment Analysis-By Application

The Soy Isoflavones Market based on the application type can be further segmented into pharmaceuticals, food and beverages, nutraceuticals. The pharmaceuticals segment held the largest share in 2021. The growth is owing to the widescale use of soy isoflavones in the fabrication of medications. Soy isoflavones have been proven beneficial in menopausal symptoms which come from progesterone and estrogen changes. On another hand, the antioxidants, anti-inflammatory, and anti-cancer properties of such polyphenolic compounds have drawn the eyes of the pharmaceutical industry toward them. The intake of the prescribed dosage of isoflavones helps lower bad cholesterol levels, muscle soreness, and cancer complications. Moreover, it too condenses the blood sugar levels in patients afflicted with diabetes. Therefore, shooting up usage of isoflavones in manufacturing drugs has provided a growth platform for the segment. Nevertheless, the pharmaceutical segment is estimated to be the fastest-growing segment with a CAGR of 4.9% over the forecast period 2022-2027. This growth is owing to the heightening intake of protein powders especially among millennials. The trend of dietary supplements’ consumption has escalated in recent years to fulfill the nutrient requirement. Such supplements help in tissue repairment, enzyme production, and strengthening the muscles. Also, rising aesthetic awareness is adding its fair contribution to the growth of the pharmaceutical segment.

Soy Isoflavones Market Segment Analysis-By Distribution Channel

The Soy Isoflavones Market based on distribution channels can be further segmented into offline platforms and online platforms. The offline segment held the largest share in 2021. The growth is owing to the across-the-board presence of offline segments such as retail pharmacies. With rapid modernization, a dramatic swing in attitudes of people from treatments to preclusion can be observed. Consequently, broadening health alertness among people is reassuring them to undertake all essential measures far in advance. Nevertheless, the online segment is estimated to be the fastest-growing segment with a CAGR of 5.7% over the forecast period 2022-2027. This growth is owing to digitalization and ameliorating online platforms, allowing more players to become a part of the market. On another hand, eventful lives of people encourage them to make online purchases as it extends additional conveniences and saves overall time. Better internet connectivity has its equitable share in connecting rural areas to cities. As a result, the overall magnitude of the tech-friendly population is rising worldwide. As of 2021, China had 953.9 million smartphone users, whereas, India grabbed the second spot with 492 million users. Therefore, considering the relentless pace of urbanization, these numbers are likely to outperform their prior shelves in upcoming years.

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Soy Isoflavones Market Segment Analysis-By Geography

The Soy Isoflavones Market based on Geography can be further segmented into North America, Europe, Asia-Pacific, South America, and the Rest of the World. The Asia-pacific segment held the largest share with 37% of the overall market in 2021. The growth in this segment is owing to the factors such as the existence of the biggest soybean consumers such as China, India, Bangladesh, and others. China was the leading consumer of soya oil in 2021 with more than 18,000 metric tonnes of consumption, whereas, India and Bangladesh collectively consumed over 6500 metric tonnes. On another hand, if we talk about production China holds 4th position worldwide in the production of (genetic modification) GM-free soya. Besides, a larger chunk of the Chinese and Japanese population is turning old and consequently heightening the demand for soy isoflavones owing to their health benefits. In 2021, 30%of the total Japanese population and more than 18% were old. The number is expected to rise in the upcoming future. Moreover, the Asia-pacific segment is expected to be the fastest-growing segment over the forecast period 2022-2027. This growth is owing to improving farming techniques and broadening of the disposable income of people.

Soy Isoflavones Market Drivers

Rising Cancer prevalence is Anticipated to Boost Product Demand

The widespread prevalence of cancer is a major driver for the aforementioned market. According to a Word health Organization report, after heart problems, cancer is the biggest reason for deaths around the globe. Last year it claimed more than 10 million lives. According to a study, around 12-13% of women in the U.S grow breast cancer complications in their lifetime. Similarly, more than 280,000 new cases are expected to be identified this year in the U.S. Besides cancer, osteoporosis cases are surging pertaining to the rising number of geriatrics. More than 200 million people worldwide are suffering from bone hitches. All these aforementioned factors are casting votes in favour of the soy isoflavones market as soy has properties to avert the prevalence of complications.

Upsurging health awareness and the use of contemporary techniques in pharmaceutical production are Expected to Boost Product Demand.

Proliferating consciousness among people is providing a sound opportunity for the growth of the market. As life-threatening health maladies are reducing the overall lifespan and quality of life, people are making more rational and wise choices such as proper exercise, healthy ingestion habits, and proper nutrient intake. The fitness industry and supplements have an inextricable connection as the majority of gym members tend to consume dietary supplements to fulfill the requirement of nutrition. According to the IHRSA report, around 2.36% of the global population had a gym membership in 2021. As the number is rising steadily so is the growth in the soy isoflavones market. On another hand, the use of contemporary techniques like nanotechnology in the fabrication of active pharmaceutical ingredients has a decent amount in the growth of the market.

Soy Isoflavones Market Challenges

Environmental problems, side effects connected with overuse, and hampered manufacturing globally are Anticipated to Hamper Market Growth.

Hackneyed use of soy isoflavones may set health complications like constipation, queasiness, swelling, itching, rashes, breathing difficulties in motion. On another hand, climate change, and environmental compilation like widespread drought, floods, and disrupted duration of seasons can impact the yield adversely. Also, the soil is losing its richness and fertility owing to the heightened use of pesticides and other chemicals. Moreover, stalled manufacturing processes owing to the reimposition of lockdowns are posing another challenge in Infront of the soy isoflavones market.

Soy Isoflavones Industry Outlook

Product launches, mergers and acquisitions, joint ventures, and geographical expansions are key strategies adopted by players in the market. Soy Isoflavones top 10 companies include:

Nexira

DSM

Bio-gen Extracts

BASF

Cargill

SK Bioland Co.

Novapac laboratories

NutraScience labs

ADM

Frutarom Industries

Recent Developments

On November 2, 2021, US-based natural ingredient and botanical extracts company, “Nexira” announced the successful acquisition of Eschenz, Switzerland-based natural-food and premium ingredient manufacturing firm “Unipektin.” The financials of the deal were not disclosed. However, the acquisition strengthened the food and nutrition portfolio of Nexira.

On August 9, 2021, two food companies have signed an agreement to acquire the US-based company “Sanderson farms.” The first company is Minnesota-based “Cargill, Inc.” and the second firm “Continental Grain Company” is based in Belgium. Both firms agreed to pay an amount of $4.53 billion collectively to Sanderson in order to complete the acquisition process. Every existing shareholder of Sanderson receive $203 for every single share they were holding.

On October 2, 2020, Heerlen, Netherland-based “Royal DSM”, a company which is famous for its nutrition and personal care products, publicized that it has acquired the “Erber Group.” The total value of these transactions stands around 980 million euros. Moreover, under the transaction, DSM gets access to Bomin and Romer labs of the Erber group.

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“Phytoestrogen Supplements  Market ”gives detailed outlook by Type, by Application, by Segmentation and Regional Forecasts.

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Global Global Daidzein  Market trends Industry Analysis Growth and Forecast 2027

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Practical Uses of Botanicals in Skin Care

Cosmeceuticals are the fastest growing sector of the cosmetic industry, and the future of antiaging cosmeceuticals in particular is very promising. Botanical pesticide that support the health, texture, and integrity of the skin, hair, and nails are widely used in cosmetic formulations. They form the largest category of cosmeceutical additives found in the marketplace today due to the rising consumer interest and demand for natural products. Various plant extracts that formed the basis of medical treatments in ancient civilizations and many traditional cultures are still used today in cleansers, moisturizers, astringents, and many other skin care products. New botanical skin care treatments are emerging, presenting dermatologists and their patients the challenge of understanding the science behind these cosmeceuticals. Thus, dermatologists must have a working knowledge of these botanicals and keep up with how they evolve to provide optimal medical care and answer patient questions. The most popular botanicals commonly incorporated into skin care protocols are discussed.

The cosmeceutical market is one of constant fluctuation depending upon consumer demand. Skin care companies are continuously pressured to release new, innovative products that promise to transform the appearance of aging skin overnight. Over the past decade, there has been fervent interest in products found in nature because of their perceived safety. Skin care products are often developed from plants. Many believe that if a product can be safely ingested, it will also be safe for topical application. In general, plant-derived, botanical feed additives, cosmeceutical products tend to be antioxidant in action since these organisms must thrive in constant direct ultraviolet (UV) light, the Earth's most prolific manufacturer of free radicals. In this article, the authors review the most popular ingredients in this class and comment on their possible usefulness in skin care protocols.

Soy extract has positive research support for its antioxidant, antiproliferative, and anticarcinogenic activities. Topical application of soy has been used to reduce hyperpigmentation, enhance skin elasticity, control oil production, moisturize the skin, and delay hair regrowth.1 Soy also has the potential to decrease photoaging of the skin and prevent skin cancers through the estrogen-type and antioxidant effects of its metabolites.1

The major components of soy are phospholipids, such as phosphatidylcholine and essential fatty acids. The minor components of soy include the most active compounds, such as isoflavones, saponins, essential amino acids, phytosterols, calcium, potassium, iron, and proteases soybean trypsin inhibitor (STI) and Bowman-Birk inhibitor (BBI). The various components of soy have a variety of beneficial effects making them useful additions to skin care products. The most potent isoflavones are the phytoestrogens known as genistein and daidzein. Genistein is a potent antioxidant that inhibits lipid peroxidation and chemical and ultraviolet light B (UVB)-induced carcinogenesis. Genistein was shown to significantly inhibit chemical, carcinogen-induced, reactive oxygen species; oxidative DNA damage; and proto-oncogene expression, as well as the initiation and promotion of skin carcinogenesis in mouse skin.2 Topical estrogens have been shown to promote collagen synthesis and increase skin thickness, which may be beneficial for postmenopausal women who develop a thinner dermis and decreased collagen.3 The small proteases STI and BBI appear to promote skin lightening and reduce unwanted facial and body hair in human clinical trials.3,4 Beyond the depigmenting activity, STI, BBI, and soy milk were also found to prevent UV-induced pigmentation both in vitro and in vivo.5 In addition, soy lipids, lecithins, and phytosterols are believed to restore barrier function and replenish moisture.

Beyond its moisturizing ability, soy appears to be a safe and effective treatment for postmenopausal women and for hyperpigmentation disorders (other than melasma, which is somewhat estrogen mediated). Although further research is necessary, the antioxidant and anticarcinogenic activities of soy and its isoflavones show a promising role for this botanical fertilizer additives in the cosmeceutical industry. Soy has therefore become a popular addition to a wide variety of skin care products (see Table 1).

Green tea extracts are among the fastest-growing herbal products. While there has been enormous growth in green tea consumption as a dietary supplement, the use of tea extracts in cosmeceutical formulations is also on the rise. The complex polyphenolic compounds in tea provide the same protective effect for the skin as for internal organs. They have been shown to modulate biochemical pathways that are important in cell proliferation, inflammatory responses, and responses of tumor promoters.6 Green tea has been shown to have anti-inflammatory and antioxidant effects in both human and animal skin.

Since inflammation and oxidative stress appear to play a significant role in the aging process, green tea may also have antiaging effects by decreasing inflammation and scavenging free radicals. Researchers have found that the main active ingredient in green tea, epigallocatechin-3-gallate (EGCG), works well as an anti-inflammatory, antioxidant, and sunscreen. Topical green tea applied to human skin has been shown to provide a photoprotective effect, reduce the number of sunburn cells, protect epidermal Langerhans cells from UV damage, and reduce the DNA damage that formed after UV radiation.7 Green tea polyphenols, when combined with traditional sunscreens, may have an additive or synergistic photoprotective effect. Green tea has also been found to decrease melanoma cells in tissue culture and squamous cell carcinoma cell formation in mice with topical and oral administration. Additionally, it improves wound healing by increasing keratinocyte cell differentiation and has been shown to inhibit Streptococcus species and Escherichia coli.8

Natural flavonoids, such as green or black tea polyphenols have been show to reduce UVB-induced erythema, tumorigenesis, and immunosuppression in mice.9,10 White tea appears to be a more potent antioxidant than green tea. Black tea has a much lower content of catechins than green tea, but a higher content of other flavonoids, such as quercetin, theaflavin, and kaempferol. Black tea extracts applied before and after UV light challenge have been shown to decrease signs of cutaneous photodamage, carcinogenesis, and inflammation in human and mouse skin.3

Most cosmeceutical products containing tea extracts or phenols have not been tested in controlled clinical trials, but these substances have shown compelling evidence for antioxidant, anti-inflammatory, and anticarcinogenic activities. There are currently several products that contain green tea extract on the market (see Table 2). Unfortunately, the concentration of phenols is not standardized in these products; therefore, some products may have little-to-no therapeutic effect, making purchasing them a challenge for consumers. It is generally accepted that five-percent green tea extract or polyphenols in the 90-percent range is an effective concentration.

German chamomile, or Matricaria recutita, has been used throughout history as an herbal treatment for various skin conditions. It functions as an antimicrobial, antiallergic, anti-inflammatory, antioxidant, and analgesic and was approved by the German Commission E for inflammatory mucocutaneous diseases and wound and burn therapy.3 The active constituents of chamomile include the terpenoids (bisoprolol, matricine, levomenol, chamazulene), flavonoids (apigenin, luteolin, rutin, quercetin), hydroxycoumarins, mono- and oligosaccharides, and mucilages. Chamazulene exhibits anti-inflammatory activity and promotes wound healing. Levomenol is an anti-inflammatory and natural moisturizing agent that has been found to diminish the signs of photodamage, reduce pruritus, and ameliorate skin texture and elasticity. In addition to reports of anti-inflammatory effects, chamomile is also purported to have some antioxidant properties, which have been identified through chemical assays.11,12

While chamomile is generally considered a safe product, there have been reports of contact dermatitis and conjunctivitis following topical application of chamomile products, and there is a potential risk of angioedema and anaphylaxis. Chamomile can also interact with warfarin, promoting an additive anticoagulant effect.

Clinical studies appear to support the traditional uses and therapeutic benefit of topical chamomile. This herb has been included in a wide variety of cosmetic products including soothing moisturizers and cleansers as well as color-enhancing hair products (see Table 3).

Caffeine, the chemical pesticide in coffee, tea, and some soft drinks, has demonstrated both anticarcinogenic and antioxidant properties. Initially, caffeine's potential inhibitory role in cancer development was found through studying oral administration of black and green tea.13 This study illustrated that the oral administration of caffeine alone and the addition of caffeine to decaffeinated teas showed inhibitory effects of UVB-induced carcinogenesis. Oral administration of caffeine has also been associated with in-vivo upregulation of tumor suppressor genes.14

Continued research revealed that topical application of caffeine inhibits carcinogenesis and promotes apoptosis in sunburn cells of hairless SKH-1, UVB-pretreated mice.15 Researchers found that topical application of the tea constituents caffeine and (-)-epigallocatechin gallate (EGCG) decreased the number of nonmalignant and malignant skin tumors in SKH-1 hairless mice pretreated with UVB. While caffeine performed better than EGCG, both treatments resulted in elevated apoptosis in nonmalignant skin tumors and squamous cell carcinomas. The results suggest a need for further studies to determine whether topical applications of caffeine or EGCG can inhibit sunlight-induced skin cancer in humans. Further studies by the same authors found that topical application of caffeine sodium benzoate and caffeine have both a sunscreen effect and enhance UVB-induced apoptosis and may be good agents for inhibiting the formation of sunlight-induced skin cancer.16

These studies present a potential use for caffeine in formulations used to decrease the risk of skin cancer formation after cutaneous damage from UV exposure. More studies need to be done to further examine caffeine's antioxidant potential. The above findings have prompted many manufacturers to add this popular agent to various cosmeceutical products on the market today (see Table 4).

Coffeeberry, harvested from the fruit of the coffee plant Coffea arabica, is considered to be one of the richest sources of antioxidants and is well known for its skin-rejuvenation properties. Coffeeberry contains potent polyphenols including chlorogenic acid, ferrulic acid, quinic acid, and condensed proanthocyanidins. The dermatologic application of CoffeeBerry® (J&J Technologies LC) extract was first recognized at the American Academy of Dermatology's Annual Meeting in February 2007. The first product to enter the market with CoffeeBerry as the basic ingredient is RevaléSkin (Stiefel Laboratories, Inc., Coral Gables, Florida) (see Table 5).

According to Stiefel Laboratories, Inc., CoffeeBerry has demonstrated high antioxidant properties, outperforming green tea extract and vitamins C and E. Proprietary research from the manufacturer has also shown that the use of the RevaléSkin CoffeeBerry skin care system consisting of 0.1% CoffeeBerry cleanser and 1% day and night creams showed statistically significant improvement in fine lines, wrinkles, pigmentation, and overall appearance when compared to vehicle. In addition to the evidence of safety and efficacy provided by the randomized, double-blind trials, further support comes from positive pathologic and in-vitro studies showing enhanced collagen production by fibroblasts. Studies are currently in progress to evaluate the use of the CoffeeBerry skin care system in conjunction with retinoids and intense pulsed-light treatments.17 More clinical studies need to be performed to fully assess the topical preparations containing CoffeeBerry extract, but polyphenols have already demonstrated efficacy in photoaging and skin cancer prevention.

The inclusion of botanical animal remedy additives in skin care products is becoming ever more popular. Potential antioxidant and anti-inflammatory benefits may prove beneficial for a number of conditions that dermatologists routinely treat, such as rosacea, photoaging, and skin cancer. The published effectiveness of prescription retinoids is well known, but equally well known is the irritation and redness often caused by the initiation of therapy. Botanicals may hold the promise of utility to reduce such inflammation. This is one of the best and most practical reasons to include botanicals in skin care protocols. Dermatologists should be aware of these products and be able to discuss their uses and potential benefits with their patients.