#cytochromep450

[cbdreviews]

Teach them early. @sacredleafcbd_tx Knowledge is power! Grateful 💚 Get your copy. www.cbd.how/book #cbdforbeginners #cbdforveterans #cbdeducationonline #cbdbooks #hempbooks #cbdoil #endocannabinoid #ecs #homeostasis #cytochromep450 #publishedauthor #author #cbd #cannabis #cbdhow #cbdreviews #hemp #hempcommunity #cbdcommunity #cannabiscommunity (at Texas) https://www.instagram.com/p/B9cyoQ-hUK1/?igshid=19j8vveixj22j

[healthtimetaylor]

A frankincense extract displayed anti-inflammatory, anti-oxidative, and hepatoprotective effects.

n/a PMID:  Front Pharmacol. 2018 ;9:387. Epub 2018 Apr 20. PMID: 29731716 Abstract Title:  Protective Effect of Casperome, an Orally Bioavailable Frankincense Extract, on Lipopolysaccharide- Induced Systemic Inflammation in Mice. Abstract:  Despite recent advances in critical care, sepsis remains a crucial cause of morbidity and mortality in intensive care units. Therefore, the identification of new therapeutic strategies is of great importance. Since ancient times, frankincense is used in traditional medicine for the treatment of chronic inflammatory disorders such as rheumatoid arthritis. Thus, the present study intends to evaluate if Casperome(Casp), an orally bioavailable soy lecithin-based formulation of standardized frankincense extract, is able to ameliorate systemic effects and organ damages induced by severe systemic inflammation using a murine model of sepsis, i.e., intraperitoneal administration of lipopolysaccharides (LPS).Male 60-day-old mice were assigned to six treatment groups: (1) control, (2) LPS, (3) soy lecithin (blank lecithin without frankincense extract), (4) Casp, (5) soy lecithin plus LPS, or (6) Casp plus LPS. Soy lecithin and Casp were given 3 h prior to LPS treatment; 24 h after LPS administration, animals were sacrificed and health status and serum cytokine levels were evaluated. Additionally, parameters representing liver damage or liver function and indicating oxidative stress in different organs were determined. Furthermore, markers for apoptosis and immune cell redistribution were assessed by immunohistochemistry in liver and spleen.LPS treatment caused a decrease in body temperature, blood glucose levels, liver glycogen content, and biotransformation capacity along with an increase in serum cytokine levels and oxidative stress in various organs. Additionally, apoptotic processes were increased in spleen besides a pronounced immune cell infiltration in both liver and spleen. Pretreatment with Casp significantly improved health status, blood glucose values, and body temperature of the animals, while serum levels of pro-inflammatory cytokines and oxidative stress in all organs tested were significantly diminished. Finally, apoptotic processes in spleen, liver glycogen loss, and immune cell infiltration in liver and spleen were distinctly reduced. Casp also appears to induce various cytochromeP450 isoforms, thus causing re-establishment of liver biotransformation capacity in LPS-treated mice.Casp displayed anti-inflammatory, anti-oxidative, and hepatoprotective effects. Thus, orally bioavailable frankincense extracts may serve as a new supportive treatment option in acute systemic inflammation and accompanied liver dysfunction.

[content-introvert]

Grapefruit #cytochromep450 inhibitor — view on Instagram https://ift.tt/2P4nVAN

[non-noxious]

Señor, eso es un paper o un arcoíris? #science #cytochromep450

[katherine-souza-holistic-health]

Grapefruit Juice & Drugs

Grapefruit juice, when digested, inhibits an important enzyme responsible for drug metabolism called CYP3A4. CYP3A4, or cytochrome P450, is mainly found in liver cells (in the mitochondria and endoplasmic reticulum), but is found elsewhere throughout the body. 

Cytochrome P450 is the most common type of enzyme in your body that does this job. Inhibition is not as extreme with other citrus despite stories I've heard of kids who enjoy their drugs with orange juice. This explains why your drug label warns you against taking it with grapefruit juice. Doing so may lead to an overdose as your body is unable to get rid of the drug. It just hangs out in your system! 

Remember this especially when taking oral contraceptives aka birth control pills.

[cbdreviews]

We would not be living without our livers. Our livers detoxify our body from anything that could potentially harm us and actually has its own cleansing system called the cytochrome p450 enzymes system. There are drugs that may interact with CBD. Why is this something to bring up about in relation to CBD? As most of us are coming to understand, CBD has the potential to effectively treat various illnesses and diseases by manipulating the endocannabinoid system with no “dirty” side effects. However, there may be one side effects to keep in mind, which is the inhibition of the cytochrome p450 enzyme system. By inhibiting the cytochrome p450 system, it may lead to an overall increase in the processing of the other drugs in your system. Thus the other drugs may not metabolize as they should. This can lead to higher levels of the other medication in your system at one time, which can cause unwanted side effects and even overdose so, if you’re taking a medication that could be affected by cannabidiol, you may need a dose adjustment in order to take both medications safely. https://www.cbd.how/cytochrome-p450-cbd-drug-interactions/ or visit our website www.cbd.how #cannabiseducation #cbdreviews #cbdeducation #cbd #cannabisheals #cbdhow #homeostasis #cbdoil #hemp #cannabiscommunity #cannabisculture #medicalcannabis #cytochromep450 #endthestigma #chronicpain #educatebeforeyoumedicate #chronicillness #stressrelief #paxil #statins #plantbased #cannabisindustry #epilepsy #plantsnotpills #druginteractions #holistichealth #cbdruginteractions (at Baltimore, Maryland) https://www.instagram.com/p/B9XBub7BaSP/?igshid=apc6jkuvp2qn