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covid-safer-hotties · 4 months ago

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The Latest Research About Paxlovid: Effectiveness, Access, and Possible Long COVID Benefits - Published Sept 6, 2024

By: Rita Rubin, MA

As another COVID-19 summer surge hit the US this year, many infected people likely were prescribed the antivirals nirmatrelvir and ritonavir, better known as Paxlovid, for the first time. Or for the fourth time. Or somewhere in between.

Nirmatrelvir-ritonavir, the only approved oral therapy for COVID-19, is recommended for treating mild to moderate SARS-CoV-2 infections among people who are at high risk of progression to severe disease. This includes people aged 50 years or older, especially those 65 years or older, as well as younger individuals who have any of a long list of comorbidities that increase the risk of severe COVID-19.

The clinical trials leading to the US Food and Drug Administration (FDA) authorizing emergency use of nirmatrelvir-ritonavir in December 2021 and approving it in May 2023 were conducted with unvaccinated people who were infected with the now long-gone SARS-CoV-2 Delta variant. This has led to questions about its effectiveness for people who have been vaccinated or have been infected with subvariants of Delta’s successor Omicron, which have been circulating for nearly 3 years.

But recent observational studies suggest nirmatrelvir-ritonavir still protects people at high risk against hospitalization and death from COVID-19. That is if they’re able to get a prescription for it—research has uncovered racial and ethnic disparities in which eligible patients get a prescription for the treatment.

And as the number of people with postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID, grows, scientists have been investigating whether nirmatrelvir-ritonavir might be useful in protecting against or treating the condition.

Does It Still Prevent Severe COVID-19?

Because the nirmatrelvir-ritonavir phase 2 and 3 trial involved unvaccinated adults without prior COVID-19 infection when the Delta variant dominated, questions have remained about its relevance today.

Scientists from Pfizer, which markets nirmatrelvir-ritonavir, and coauthors recently published a systematic literature review examining that question. They searched for real-world studies reported from December 2021 through March 2023 and identified 18 that met their final selection criteria.

The evidence showed that nirmatrelvir-ritonavir was effective regardless of age, underlying high-risk conditions, or vaccination status. The treatment significantly reduced the postinfection risk of all-cause and COVID-19–related mortality both within the first 30 days and in the long-term. Treatment started within 5 days of symptom onset, as recommended on the label, was associated with the greatest reduction in postinfection risk.

“We remain very confident in Paxlovid’s clinical effectiveness at preventing severe outcomes, including hospitalization and death, from COVID-19 in patients at high risk of severe disease,” Pfizer spokesperson Kit Longley said in an early August email.

Another recently published study reached a somewhat different conclusion. That study, conducted by University of Manitoba researchers, analyzed results from 4 randomized trials and 16 real-world studies, some of which had not yet been peer-reviewed, with a total of nearly 2 million adults aged 18 years or older.

The evidence suggested nirmatrelvir-ritonavir has a small but significant efficacy in reducing COVID-19 hospitalization and all-cause mortality among people with laboratory-confirmed mild to moderate infections, but the evidence is weak, so more studies are needed, the authors concluded.

At Risk but No Script

COVID-19 laid bare health disparities in the US, and nirmatrelvir-ritonavir has been no exception, according to a study published in August.

Using National COVID Cohort Collaborative (N3C) data, researchers studied individuals 18 years of age or older who were diagnosed with COVID-19 between January 2022 and December 2023; up until the end of that period, the US government covered the cost of nirmatrelvir-ritonavir for everyone who needed it.

About 1.26 million people in the N3C cohort were at high risk of progressing to severe disease, making them eligible for nirmatrelvir-ritonavir treatment. But overall, nearly two-thirds of those who were eligible weren’t prescribed the treatment, the authors observed. After accounting for age, sex, and clinical characteristics, the researchers found that non-Hispanic Black and Latino individuals were nearly a third less likely to have used nirmatrelvir-ritonavir than non-Hispanic White individuals.

Patients may not seek care or may not seek it out early enough for the treatment to be effective, coauthor Hemalkumar Mehta, PhD, a core member of the N3C, speculated in an interview with JAMA Medical News.

Another reason could be that patients don’t have a regular source of primary care whom they could ask for a prescription, noted Mehta, a pharmacist and epidemiologist at the Johns Hopkins Bloomberg School of Public Health. They likely don’t know that the FDA has authorized state-licensed pharmacists to prescribe nirmatrelvir-ritonavir, he said.

Mehta acknowledged that until he conducted his study, even he didn’t realize that pharmacists could prescribe the COVID-19 treatment. Publicizing that fact by simply hanging a sign in pharmacies would help, he pointed out.

However, the FDA created an obstacle to quick prescribing of nirmatrelvir-ritonavir by pharmacists, a 2023 article noted. Prior to prescribing, pharmacists must assess patients’ liver and kidney function through health records from the previous 12 months or consultation with their clinician. Other prescribers can simply ask patients about their liver and kidney function and take their word for it, the authors explained. In addition, there is no standardized pathway for pharmacists to bill payors for assessing patients to see if they’re eligible for nirmatrelvir-ritonavir, which typically takes 15 to 30 minutes, according to the American Pharmacists Association.

When people do get a prescription for nirmatrelvir-ritonavir, most get it filled, a recently published study of Walgreens pharmacies nationwide data found. The retrospective study included people 12 years of age or older for whom a nirmatrelvir-ritonavir prescription was ordered from Walgreens pharmacies between December 2021 and August 2023.

A total of about 2.1 million nirmatrelvir-ritonavir prescriptions were ordered for about 2 million individuals. Among the 95% of people who were prescribed only 1 course of the treatment, 88% filled their prescription. Improving uptake of nirmatrelvir-ritonavir requires increasing patient and prescriber awareness, reducing prescribing disparities, and ensuring treatment initiation within 5 days of symptom onset, the authors concluded.

Treat Acute Infection, Prevent Long COVID?

Taking nirmatrelvir-ritonavir for acute COVID-19 might protect against long COVID, although research into that topic has had mixed results.

For example, 2 recent studies, neither of which had yet been peer-reviewed, reached different conclusions.

A preprint posted in June reported observational study results from the Researching COVID to Enhance Recovery (RECOVER) initiative funded by the US National Institutes of Health (NIH). The study population included nearly 500 000 people who tested positive for SARS-CoV-2 between March 2022 and February 2023. Of those, about 165 000 were treated with nirmatrelvir-ritonavir within 5 days after becoming infected.

Compared with no treatment, nirmatrelvir-ritonavir therapy was associated with a 12% lower risk of developing long COVID within 180 days of infection, or an absolute risk reduction of about 3 cases per 100 people. However, no such risk reduction was seen in people at low risk of severe COVID-19 infection who received nirmatrelvir-ritonavir.

“There are quite a few patients who are not at risk but who received a Paxlovid prescription,” first author Fei Wang, PhD, explained in an interview with JAMA Medical News. “This provides us an opportunity to evaluate a low-risk population that got COVID.”

Another preprint, posted this summer, used N3C electronic health records. It found that nirmatrelvir-ritonavir treatment of acute COVID-19 was not significantly associated with reducing long COVID overall, although it was linked to fewer cognitive and fatigue symptoms.

The mixed findings between the 2 studies aren’t surprising, said Wang, an assistant professor of health care policy and research at Weill Cornell Medicine.

Some information, such as COVID-19 vaccination history and nirmatrelvir-ritonavir use, isn’t always encoded in electronic health records, Wang pointed out. Although he and his colleagues “spend a lot of effort” to make sure they have complete patient information, Wang explained, “there’s no way we can evaluate how complete that is.”

He added that not having a consensus definition of long COVID is another critical issue. The N3C’s definition isn’t the same as RECOVER’s, and the 2 cohorts have different patient populations. “All these can lead to different results,” he said.

For Wang, it makes sense that taking nirmatrelvir-ritonavir, an antiviral, for acute COVID-19 would protect against long COVID. The severity of acute SARS-CoV-2 infections is correlated with the risk of long COVID, he said, and one theory about the cause of PASC is the persistence of SARS-CoV-2 in the body.

However, Yale cardiologist Harlan Krumholz, MD, SM, pointed out that unidentified confounders, not nirmatrelvir-ritonavir itself, might be at play in the relationship between treating acute SARS-CoV-2 infection and long COVID risk. “People who take Paxlovid might be different in many other ways,” he noted.

A Long COVID Treatment?

Many individuals with long COVID didn’t have the opportunity to take nirmatrelvir-ritonavir when they first became ill with acute COVID-19. They might have been infected before the treatment became available, or they weren’t considered to be at high risk for severe disease, so they weren’t eligible for it.

Some case reports have suggested that it might not be too late for people who’ve had long COVID for months to benefit from nirmatrelvir-ritonavir. For example, in early 2023 internist Linda Geng, MD, PhD, codirector of Stanford’s PASC clinic, and coauthors reported the case of a patient who’d had long COVID for 7 months, around which time the symptoms of acute COVID-19 returned. Although rapid antigen test results were negative, the patient had been exposed to multiple people with COVID-19, so a primary care physician prescribed nirmatrelvir-ritonavir. Not only did the acute flu-like symptoms resolve, but so did the long COVID symptoms, which included severe fatigue and cognitive difficulties.

That patient spurred Geng and her colleagues to conduct what they say is the first published randomized trial of nirmatrelvir-ritonavir to treat PASC, which appeared in June in JAMA Internal Medicine. The trial enrolled 155 participants with long COVID, all but 2 of whom had received the primary COVID-19 vaccination series. On average, the time between their initial SARS-CoV-2 infection and randomization into the trial was about a year and a half.

The trial found that the longer 15-day course of nirmatrelvir-ritonavir it used was generally safe. However, the treatment didn’t significantly improve long COVID symptoms compared with the control group.

It’s far from the final answer about nirmatrelvir-ritonavir’s effectiveness against long COVID, though, Geng noted. “This is just the first step in many investigations that need to be done.”

The NIH is funding several clinical trials targeting long COVID under the RECOVER initiative umbrella. One, the Platform Protocol to Measure the Effects of Antiviral Therapies on Long COVID Symptoms (RECOVER-VITAL), is testing an even longer course of nirmatrelvir-ritonavir among an estimated 900 participants at centers throughout the US.

And Krumholz and colleagues at Yale University are in the process of analyzing data from their placebo-controlled randomized trial of nirmatrelvir-ritonavir in 100 patients with long COVID. (The trial received funding and design input from Pfizer.)

“We’re not sure it works,” said Krumholz, founder and director of the Yale New Haven Hospital Center for Outcomes Research and Evaluation. “What I think we need are a lot more studies of 100 people or 200 people, trying a lot more things” to treat long COVID.

Participants in the Yale trial were all highly symptomatic and lived throughout the contiguous US. Instead of having them go to participating centers, the trial came to them. “Setting up centers is expensive,” Krumholz explained, noting that the trial’s decentralized design could help cut costs and could work for a variety of conditions and treatments.

Participants were shipped the medication. They gave blood and saliva samples at a local laboratory or at home and answered questions about their symptoms in a digital diary. Yale colleague Akiko Iwasaki, PhD, who studies antiviral immunity and viral disease pathogenesis, is looking at the blood and saliva samples for differences between people who appeared to respond to nirmatrelvir-ritonavir and those who didn’t.

Paxlovid 2.0?

Meanwhile, Pfizer is working to eliminate what one recent publication referred to as nirmatrelvir-ritonavir’s Achilles’ heel: the limited metabolic stability of nirmatrelvir, a protease inhibitor that requires ritonavir to boost it to the target therapeutic range.

The problem is that ritonavir boosts the plasma levels of a long list of other medications beyond the therapeutic range, so nirmatrelvir-ritonavir is contraindicated for people taking them, unless they can temporarily stop or reduce the dose of the concomitant drugs while taking the COVID-19 treatment. Ritonavir is also the source of the metallic taste many individuals who take Paxlovid experience.

Pfizer’s second-generation protease inhibitor for treating COVID-19 is called ibuzatrelvir. Although it’s structurally related to nirmatrelvir, ibuzatrelvir has greater bioavailability when taken orally, so it doesn’t require a ritonavir boost.

Pfizer has completed a phase 2B trial testing the safety and efficacy of a 5-day course of ibuzatrelvir treatment. Participants were nonhospitalized individuals aged 18 to 65 years with confirmed COVID-19 whose symptoms began within 5 days of randomization. Ibuzatrelvir showed robust antiviral activity in the trial, with statistically significant, dose-dependent decreases in viral load at days 3 and 5 compared with placebo, Pfizer researchers reported in April at the European Congress of Clinical Microbiology and Infectious Diseases.

“It is premature to speculate on potential timing of phase 3, but we are considering next steps and plan to share updates as they are available,” Pfizer spokesperson Longley said.

Meanwhile, SARS-CoV-2 continues to evolve along with attitudes toward COVID-19, Krumholz said. Many people “are treating it like a head cold,” he explained. “They’ve obviously made the determination that it’s not dangerous, but it is dangerous.”

Published Online: September 6, 2024. doi:10.1001/jama.2024.16432

#covid #mask up #pandemic #covid 19 #wear a mask #coronavirus #sars cov 2 #public health #still coviding #wear a respirator

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beardedmrbean · 1 month ago

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One of the central organisers behind the "Freedom Convoy" protest that caused Canada’s capital to descend into gridlock for weeks in 2022 has been found guilty of mischief.

Pat King, 47, is the first leader of the protests to learn of his verdict. Two others, Tamara Lich and Chris Barber, will learn the outcome of their trials within the next six months.

A judge in an Ottawa courtroom on Friday found King guilty on five counts, including one count each of mischief, counselling others to commit mischief and counselling others to obstruct police.

King, who had led a convoy of lorries in Ottawa in protest of Covid-19 measures and Prime Minister Justin Trudeau's government, had pleaded not guilty.

King was also found guilty of two counts of disobeying a court order, but the judge did not find him guilty of two other charges he faced - intimidation and obstructing police.

Estimates made prior to the trial suggested that King could face up to 10 years in prison.

Lawyers for King argued during his trial that he was part of a peaceful protest against public health restrictions and government mandates, and that police were to blame for rising tensions during the demonstrations.

Crown prosecutors, however, argued that King was a key figure of a protest that had disrupted and harmed the residents and workers of downtown Ottawa for weeks.

They detailed one instance where King allegedly helped move 80 lorries to block a major street in the city, and another where he allegedly instructed protestors to honk their horns every 30 minutes.

Organisers of the Freedom Convoy, including Ms Lich and Mr Barber, are also facing a C$300m ($222m; £175m) civil lawsuit brought against them by Ottawa residents over the disruptions they caused in the city.

Crown prosecutors relied mainly on King's own videos to make their case, which he posted on social media throughout the demonstration to communicate with fellow protesters.

The February 2022 protests were initially sparked by a federal vaccine mandate for lorry drivers crossing the US-Canada border.

Convoys of some 400 heavy trucks and other vehicles descended on Ottawa and blockaded city streets around parliament for three weeks.

City officials deemed it an "occupation".

Separate protests also blocked a key US-Canada border crossing near Detroit, angering the White House and disrupting the flow of goods. Other border points were blocked in Alberta and Manitoba.

The protests received international attention and inspired similar copycat demonstrations abroad.

They were stopped after Prime Minister Trudeau enacted a never-before-used Emergencies Act, which allowed police to clear the streets and freeze the bank accounts of protesters.

King was arrested shortly after on 18 February and was released on bail five months later.

He was ordered back behind bars briefly this year after he breached court-imposed rules on his social media use.

King has been charged in a separate case with perjury and obstruction of justice related to testimony he gave at a bail hearing. The trial dates for that case have not yet been set.

#nunyas news #this is a hit job

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kimabutch · 1 year ago

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a double congrats on seminary!! feel free to ignore this if it's too personal/complicated/you don't want to answer for any reason, but i wasn't aware that the anglican church was chill about queer people? most of my knowledge comes from having a special interest in cs lews though lol. is it one of those denominations that varies from church to church?

Double thanks!!

And the Anglican Communion is... complicated. Unlike the Roman Catholics, each national Anglican Church is independent and autonomous, and while they have occasional get-togethers (Lambeth Conferences) and make resolutions, those resolutions aren't legally binding. What this means is that Anglicanism can look pretty different depending on where you are and Anglicans worldwide have some pretty deep disagreements.

Queer people are one of those points of deep disagreements, and in fact at our last few Lambeth Conferences, there have been intense debate about it — at the conference last year, some conservative bishops refused to take communion with pro-queer bishops, and many pro-queer bishops (including my own!) wrote a letter affirming queerness.

The Anglican Church of Canada specifically is generally better about queer people; as you said, it varies, but more at a diocese (regional) level than a church-to-church level, because of the power afforded to dioceses to make their own decisions about things. My own diocese has allowed priests to preside over gay marriage for over 10 years, and has been blessing gay unions for 20. In various dioceses in Ontario, we've had openly gay priests and at least one gay bishop, and Manitoba's got an openly trans priest (so at least I wouldn't be the first in Canada!) I marched with my church and diocese in my local pride parade this summer; my church has a gay flag on it and has been pro-queer since before Canada allowed gay marriage. I have so many wonderful little stories about my church being affirming, actually, but I'll save those for another time — I'll just say that it's one of the places that I feel safest as a nonbinary person.

Other regions, particularly in the prairies, aren't so chill. Some conservative churches have broken away from the Anglican Church because anyone likes gay people. There's been a lot of effort at a national level to pass an act that would allow gay marriage throughout all Anglican churches in Canada, but it's still not happened, for reasons ranging from homophobic churches to COVID-19. I think one day it will, but for now, it's super shitty and sometimes causes me a lot of grief and anger. It's the reason I considered leaving the Anglican Church entirely, despite loving so many of its traditions and ways of worship. I decided it was worth it in the end, especially as I'm so supported in my region, but yeah, it's hard.

Anyways, yes, it's complicated!

#wow I didn't intend for this to go on so long!#if you're interested in more of the details wikipedia actually has a fair number of articles on it #especially for the Anglican churches outside Canada which I know much less about #although I know there are a few other national churches that are pretty cool about it #christianity

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taylors-husband · 1 year ago

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Taylor Swift Headlining Tours List.

Concert Tours.

Fearless Tour: 23 April, 2009 - 10 July, 2010.

Speak Now World Tour: 9 February, 2011 - 18 March, 2012.

The Red Tour: 13 March, 2013 - 12 June, 2014.

The 1989 World Tour: 5 May, 2015 - 12 December, 2015.

Reputation Stadium Tour: 8 May, 2018 - 21 November, 2018.

Lover Fest: 5 April, 2020 - 1 August, 2020. (Cancelled due to the worldwide COVID-19 pandemic).

The Eras Tour: 17 March, 2023 - 23 November, 2024.

Total number of concerts: 572.

Total number of postponed concerts: 8

Total number of cancelled concerts: 18.

Argentina (3).

Buenos Aires (3).

9 November, 2023 - Estadio River Plate.

10 November, 2023 - Estadio River Plate.

11 November, 2023 - Estadio River Plate.

Australia (34).

New South Wales (12).

Newcastle (1).

8 February, 2010 - Newcastle Entertainment Centre.

Sydney (11).

6 February, 2010 - Acer Arena.

7 February, 2010 - Acer Arena.

9 March, 2012 - Allphones Arena.

10 March, 2012 - Allphones Arena.

4 December, 2013 - Allianz Stadium.

28 November, 2015 - ANZ Stadium.

2 November, 2018 - ANZ Stadium.

23 February, 2024 - Accor Stadium.

24 February, 2024 - Accor Stadium.

25 February, 2024 - Accor Stadium.

26 February, 2024 - Accor Stadium.

Queensland (7).

Brisbane (7).

4 February, 2010 - Brisbane Entertainment Centre.

6 March, 2012 - Brisbane Entertainment Centre.

7 March, 2012 - Brisbane Entertainment Centre.

7 December, 2013 - Suncorp Stadium.

5 December, 2015 - Brisbane, Queensland (Australia) - Suncorp Stadium.

6 November, 2018 - The Gabba.

South Australia (4).

Adelaide (4).

12 February, 2010 - Adelaide Entertainment Centre.

4 March, 2012 - Adelaide Entertainment Centre.

7 December, 2015 - Adelaide Entertainment Centre.

8 December, 2015 - Adelaide Entertainment Centre.

Victoria (12).

Melbourne (12).

10 February, 2010 - Rod Laver Arena.

11 February, 2010 - Rod Laver Arena.

12 March, 2012 - Rod Laver Arena.

13 March, 2012 - Rod Laver Arena.

14 March, 2012 - Rod Laver Arena.

14 December, 2013 - Etihad Stadium.

10 December, 2015 - AAMI Park.

11 December, 2015 - AAMI Park.

26 October, 2018 - Marvel Stadium.

16 February, 2024 - Melbourne Cricket Ground.

17 February, 2024 - Melbourne Cricket Ground.

18 February, 2024 - Melbourne Cricket Ground.

Western Australia (3).

Perth (3).

2 March, 2012 - Burswood Dome.

11 December, 2013 - nib Stadium.

19 October, 2018 - Optus Stadium.

Austria (3).

Vienna (3).

8 August, 2024 - Ernst-Happel-Stadion.

9 August, 2024 - Ernst-Happel-Stadion.

10 August, 2024 - Ernst-Happel-Stadion.

The Bahamas (1).

Paradise Island (1).

19 June, 2010 - Imperial Ballroom.

Brazil (6, 2 cancelled).

Rio de Janiero (3).

17 November, 2023 - Estadio Nilton Santos.

18 November, 2023 - Estadio Nilton Santos.

19 November, 2023 - Estadio Nilton Santos.

Sao Paulo (3, 2 cancelled).

18 July, 2020 - Allianz Parque. (Cancelled due to the worldwide COVID-19 pandemic).

19 July, 2020 - Allianz Parque. (Cancelled due to the worldwide COVID-19 pandemic).

24 November, 2023 - Allianz Parque.

25 November, 2023 - Allianz Parque.

26 November, 2023 - Allianz Parque.

Belgium (1, 1 cancelled).

Brussels (1).

6 March, 2011 - Forest National.

Werchter (1 cancelled).

20 June, 2020 - Werchter Boutique (Festivalpark). (Cancelled due to the worldwide COVID-19 pandemic).

Canada (36).

Alberta (8).

Calgary (1).

8 July, 2009 - Pengrowth Saddledome.

Edmonton (7).

9 July, 2009 - Commonwealth Country (Commonwealth Stadium).

18 August, 2011 - Rexall Place.

19 August, 2011 - Rexall Place.

25 June, 2013 - Rexall Place.

26 June, 2013 - Rexall Place.

4 August, 2015 - Rexall Place.

5 August, 2015 - Rexall Place.

British Columbia (4).

Vancouver (4).

10 September, 2011 - Rogers Arena.

11 September, 2011 - Rogers Arena.

29 June, 2013 - BC Place Stadium.

1 August, 2015 - BC Place Stadium.

Manitoba (2).

Winnipeg (2).

11 July, 2009 - MTS Centre.

22 June, 2013 - Investors Group Field.

Ontario (18).

Ottawa (2).

20 May, 2010 - Scotiabank Place.

6 July, 2015 - Canadian Tire Centre.

Toronto (10).

21 May, 2010 - Air Canada Center.

22 May, 2010 - Air Canada Center.

15 July, 2011 - Rogers Centre.

16 July, 2011 - Rogers Centre.

14 June, 2013 - Rogers Centre.

15 June, 2013 - Rogers Centre.

2 October, 2015 - Rogers Centre.

3 October, 2015 - Rogers Centre.

3 August, 2018 - Rogers Centre.

4 August, 2018 - Rogers Centre.

14 November, 2024 - Rogers Centre.

15 November, 2024 - Rogers Centre.

16 November, 2024 - Rogers Centre.

21 November, 2024 - Rogers Centre.

22 November, 2024 - Rogers Centre.

23 November, 2024 - Rogers Centre.

Prince Edward Island (1).

Cavendish (1).

10 July, 2010 - Cavendish Beach Music Festival 2010 (Cavendish Beach Festival Grounds).

Quebec (2).

Montreal (2).

14 July, 2011 - Bell Centre.

7 July, 2015 - Bell Centre.

Saskatchewan (1).

Craven (1).

10 July, 2009 - Craven Country Jamboree (Big Valley Park).

China (4).

Shanghai (4).

30 May, 2014 - Mercedes-Benz Arena.

10 November, 2015 - Mercedes-Benz Arena.

11 November, 2015 - Mercedes-Benz Arena.

12 November, 2015 - Mercedes-Benz Arena.

Denmark (1 cancelled).

Roskilde (1 cancelled).

1 July, 2020 - Roskilde Festival (Roskilde Fairgrounds). (Cancelled due to the worldwide COVID-19 pandemic).

England (29, 2 cancelled).

Birmingham (1).

22 March, 2011 - LG Arena.

Chelmsford (1).

22 August, 2009 - V Festival (Hylands Park).

Liverpool

13 June, 2024 - Anfield.

14 June, 2024 - Anfield.

15 June, 2024 - Anfield.

London (12, 1 cancelled).

6 May, 2009 - Shepherd’s Bush Empire.

7 May, 2009 - Shepherd’s Bush Empire.

23 November, 2009 - Wembley Arena.

30 March, 2011 - The O2 Arena.

1 February, 2014 - The O2 Arena.

2 February, 2014 - The O2 Arena.

4 February, 2014 - The O2 Arena.

10 February, 2014 - The O2 Arena.

11 February, 2014 - The O2 Arena.

27 June, 2015 - British Summertime (Hyde Park).

22 June, 2018 - Wembley Stadium.

23 June, 2018 - Wembley Stadium.

11 July, 2020 - British Summer Time (Hyde Park). (Cancelled due to the worldwide COVID-19 pandemic).

21 June, 2024 - Wembley Stadium.

22 June, 2024 - Wembley Stadium.

23 June, 2024 - Wembley Stadium.

15 August, 2024 - Wembley Stadium.

16 August, 2024 - Wembley Stadium.

17 August, 2024 - Wembley Stadium.

Manchester (5).

24 November, 2009 - Manchester Evening News Arena.

29 March, 2011 - Manchester Evening News Arena.

24 June, 2015 - Phones 4u Arena Manchester.

8 June, 2018 - Etihad Stadium.

9 June, 2018 - Etihad Stadium.

Pilton (1 cancelled).

28 June, 2020 - Glastonbury Festival (Worthy Farm). (Cancelled due to the worldwide COVID-19 pandemic).

Staffordshire (1).

23 August, 2009 - V Festival (Weston Park).

France (7, 1 cancelled).

Lyon (2).

2 June, 2024 - Groupama Stadium.

3 June, 2024 - Groupama Stadium.

Nîmes (1 cancelled).

5 July, 2020 - Festival de Nîmes (Arena of Nîmes). (Cancelled due to the worldwide COVID-19 pandemic).

Paris (5).

17 March, 2011 - Le Zénith.

9 May 2024 - Paris La Défense Arena.

10 May 2024 - Paris La Défense Arena.

11 May 2024 - Paris La Défense Arena.

12 May 2024 - Paris La Défense Arena.

Germany (11, 2 cancelled)

Berlin (1, 1 cancelled).

7 February, 2014 - O2 World.

24 June, 2020 - The Waldbühne. (Cancelled due to the worldwide COVID-19 pandemic).

Cologne (2).

19 June, 2015 - Lanxess Arena.

20 June, 2015 - Lanxess Arena.

Gelsenkirchen (3).

17 July, 2024 - VELTINS-Arena.

18 July, 2024 - VELTINS-Arena.

19 July, 2024 - VELTINS-Arena.

Hamburg (2).

23 July, 2024 - Volksparkstadion.

24 July, 2024 - Volksparkstadion.

Munich (2, 1 cancelled).

14 March, 2011 - Olympiahalle. (Cancelled due to overlapping of promotional activities. When this concert was cancelled, ticketholders were given the opportunity to attend the Oberhausen concert).

27 July, 2024 - Olympiastadion.

28 July, 2024 - Olympiastadion.

Oberhausen (1).

12 March, 2011 - Konig-Pilsener Arena.

Hong Kong (1).

21 February, 2011 - AsiaWorld-Arena.

Indonesia (1).

Jakarta (1).

4 June, 2014 - Mata Elang International Stadium.

Italy (3).

Milan (3).

15 March, 2011 - Mediolabum Forum.

13 July, 2024 - San Siro Stadium.

14 July, 2024 - San Siro Stadium.

Ireland (8).

Dublin (8).

27 March, 2011 - The O2.

29 June, 2015 - 3Arena.

30 June, 2015 - 3Arena.

15 June, 2018 - Croke Park.

16 June, 2018 - Croke Park.

28 June, 2024 - Aviva Stadium.

29 June, 2024 - Aviva Stadium.

30 June, 2024 - Aviva Stadium.

Japan (13).

Osaka (1).

13 February, 2011 - Osaka-Jo Hall.

Tokyo (12).

17 February, 2010 - Zepp Tokyo.

16 February, 2011 - Nippon Budokan.

17 February, 2011 - Nippon Budokan.

1 June, 2014 - Saitama Super Arena.

5 May, 2015 - TokyoDome.

6 May, 2015 - TokyoDome.

20 November, 2018 - TokyoDome.

21 November, 2018 - TokyoDome.

7 February, 2024 - TokyoDome.

8 February, 2024 - TokyoDome.

9 February, 2024 - TokyoDome.

10 February, 2024 - TokyoDome.

Malaysia (1).

Kuala Lumpur.

11 June, 2014 - Stadium Putra Bukit Jalil.

Mexico (4).

Mexico City (4).

24 August, 2023 - Foro Sol.

25 August, 2023 - Foro Sol.

26 August, 2023 - Foro Sol.

27 August, 2023 - Foro Sol.

Netherlands (6).

Amsterdam (4).

21 June, 2015 - Ziggo Dome.

4 July, 2024 - Johan Cruijff ArenA.

5 July, 2024 - Johan Cruijff ArenA.

6 July, 2024 - Johan Cruijff ArenA.

Rotterdam (1).

7 March, 2011 - Ahoy.

New Zealand (7).

Auckland (7).

16 March, 2012- Vector Arena.

17 March, 2012 - Vector Arena.

18 March, 2012 - Vector Arena.

29 November, 2013 - Vector Arena.

30 November, 2013 - Vector Arena.

1 December, 2013 - Vector Arena.

9 November, 2018 - Mt. Smart Stadium.

Northern Ireland (1).

Belfast (1).

25 March, 2011 - Odyssey Arena.

Norway (1, 1 cancelled).

Oslo (1, 1 cancelled).

9 March, 2011 - Oslo Spektrum.

26 June, 2020 - Oslo Sommertid (Voldøkka). (Cancelled due to the worldwide COVID-19 pandemic).

Philippines (2).

Manila (2).

19 February, 2011 - Smart Araneta Coliseum.

6 June, 2014 - Mall of Asia Arena.

Poland (3, 1 cancelled).

Gdynia (1 cancelled).

3 July, 2020 - Open’er Festival (Babie Doly Airport). (Cancelled due to the worldwide COVID-19 pandemic).

Warsaw.

1 August, 2024 - PGE Narodowy.

2 August, 2024 - PGE Narodowy.

3 August, 2024 - PGE Narodowy.

Portugal (2, 1 cancelled).

Lisbon (2).

24 May, 2024 - Estádio da Luz.

25 May, 2024 - Estádio da Luz.

Oerias (1 cancelled).

9 July, 2020 - Nos Festival (Passeio Marítimo de Algés). (Cancelled due to the worldwide COVID-19 pandemic).

Scotland (4).

Edinburgh (3).

7 June, 2024 - Murrayfield Stadium

8 June, 2024 - Murrayfield Stadium.

9 June, 2024 - Murrayfield Stadium.

Glasgow (1).

23 June, 2015 - SSE Hydro.

Singapore (11).

9 February, 2011 - Singapore Indoor Stadium.

9 June, 2014 - Singapore Indoor Stadium.

12 June, 2014 - Singapore Indoor Stadium.

7 November, 2015 - Singapore Indoor Stadium.

8 November, 2015 - Singapore Indoor Stadium.

2 March, 2024 - National Stadium.

3 March, 2024 - National Stadium.

4 March, 2024 - National Stadium.

7 March, 2024 - National Stadium.

8 March, 2024 - National Stadium.

9 March, 2024 - National Stadium.

South Korea (1).

Seoul (1).

11 February, 2011 - Olympic Park Gymnastics Arena.

Spain (2, 1 cancelled).

Madrid (2, 1 cancelled).

19 March, 2011 - Palacio de los Deportes.

8 July, 2020 - Mad Cool Festival (IFEMA). (Cancelled due to the worldwide COVID-19 pandemic).

30 May, 2024 - Estadio Santiago Bernabéu.

Sweden (3).

Stockholm (3).

17 May, 2024 - Friends Arena.

18 May, 2024 - Friends Arena.

19 May, 2024 - Friends Arena.

Switzerland (2).

Zürich (2).

9 July, 2024 - Stadion Letzigrund Zürich.

10 July, 2024 - Stadion Letzigrund Zürich.

Thailand (1 cancelled).

Bangkok (1 cancelled).

9 June, 2014 - Impact Arena. (Cancelled and moved to Singapore due to the 2014 Thai coup d’etat.

Ticketholders for the Bangkok concert were given the opportunity to attend the Singapore concert.

United States (362, 8 postponed, 4 cancelled).

Alabama (2).

Birmingham (1).

11 September, 2009 - BJCC Arena.

Enterprise (1).

4 June, 2009 - BamaJam Farms.

Arizona (10).

Phoenix/Glendale (10).

21 May, 2009 - Jobing(dot)com Arena.

21 October, 2011 - Jobing(dot)com Arena.

22 October, 2011 - Jobing(dot)com Arena.

28 May, 2013 - Jobing(dot)com Arena.

29 May, 2013 - Jobing(dot)com Arena.

17 August, 2015 - Gila River Arena.

18 August, 2015 - Gila River Arena.

8 May, 2018 - University Of Phoenix Stadium.

17 March, 2023 - State Farm Stadium.

18 March, 2023 - State Farm Stadium.

Arkansas (3).

Jonesboro (1).

24 April, 2009 - ASU Convocation Center.

Little Rock (2).

26 September, 2009 - Verizon Arena.

4 October, 2011 - Verizon Arena.

California (38, 4 cancelled).

Fresno (1).

10 April, 2010 - Save Mart Center at Fresno State.

Inglewood/Los Angeles/Pasadena (23, 2 cancelled).

22 May, 2009 - Staples Center.

15 April, 2010 - Staples Center.

16 April, 2010 - Staples Center.

23 August, 2011 - Staples Center.

24 August, 2011 - Staples Center.

27 August, 2011 - Staples Center.

28 August, 2011 - Staples Center.

19 August, 2013 - Staples Center.

20 August, 2013 - Staples Center.

23 August, 2013 - Staples Center.

24 August, 2013 - Staples Center.

21 August, 2015 - Staples Center.

22 August, 2015 - Staples Center.

25 August, 2015 - Staples Center.

26 August, 2015 – Staples Center.

18 May, 2018 - Rose Bowl.

19 May, 2018 - Rose Bowl.

25 July, 2020 - Lover Fest West (Sofi Stadium). Cancelled due to the worldwide COVID-19 pandemic.

26 July, 2020 - Lover Fest West (Sofi Stadium). Cancelled due to the worldwide COVID-19 pandemic.

3 August, 2023 - SoFi Stadium.

4 August, 2023 - SoFi Stadium.

5 August, 2023 - SoFi Stadium.

7 August, 2023 - SoFi Stadium.

8 August, 2023 - SoFi Stadium.

9 August, 2023 - SoFi Stadium.

Sacramento (2).

3 September, 2011 - Power Balance Pavilion.

27 August, 2013 - Sleep Train Arena.

San Diego (4).

24 May, 2009 - San Diego Sports Arena.

20 October, 2011 - Valley View Casino Center.

15 August, 2013 - Valley View Casino Center.

29 August, 2015 - PETCO Park.

San Jose/Santa Clara (8).

11 April, 2010 - HP Pavilion.

1 September, 2011 - HP Pavilion.

2 September, 2011 - HP Pavilion.

15 August, 2015 - Levi’s Stadium.

11 May, 2018 - Levi’s Stadium.

12 May, 2018 - Levi’s Stadium.

28 July, 2023 - Levi’s Stadium.

29 July, 2023 - Levi’s Stadium.

Colorado (9).

Denver (9).

6 April, 2010 - Pepsi Center.

7 April, 2010 - Pepsi Center.

27 September, 2011 - Pepsi Center.

2 June, 2013 - Pepsi Center.

5 September, 2015 - Pepsi Center.

6 September, 2015 - Pepsi Center.

25 May, 2018 - Sports Authority Field At Mile High.

14 July, 2023 - Empower Field at Mile High.

15 July, 2023 - Empower Field at Mile High.

Connecticut (2).

Hartford (1).

22 June, 2011 - XL Center.

Uncasville (1).

28 August, 2009 - Mohegan Sun Arena.

Florida (24).

Ft. Lauderdale (3).

7 March, 2010 - BankAtlantic Center.

2 June, 2011 - BankAtlantic Center.

3 June, 2011 - BankAtlantic Arena.

Jacksonville (2).

1 May, 2009 - Veterans Memorial Arena.

11 November, 2011 - Veterans Memorial Arena.

Miami (7).

13 November, 2011 - American Airlines Arena.

10 April, 2013 - American Airlines Arena.

27 October, 2015 - American Airlines Arena.

18 August, 2018 - Hard Rock Stadium.

18 October, 2024 - Hard Rock Stadium.

19 October, 2024 - Hard Rock Stadium.

20 October, 2024 - Hard Rock Stadium.

Orlando (4).

5 March, 2010 - Amway Arena.

4 June, 2011 - Amway Center.

11 April, 2013 - Amway Center.

12 April, 2013 - Amway Center.

Tampa (8).

4 March, 2010 - St. Pete Times Forum.

12 November, 2011 - St. Pete Times Forum.

20 April, 2013 - Tampa Bay Times Forum.

31 October, 2015 - Raymond James Stadium.

14 August, 2018 - Raymond James Stadium.

13 April, 2023 - Raymond James Stadium.

14 April, 2023 - Raymond James Stadium.

15 April, 2023 - Raymond James Stadium.

Georgia (10).

Atlanta (10, 2 postponed, 1 cancelled).

9 July, 2011 - Phillips Arena. This concert was postponed because Taylor had bronchitis.

10 July, 2011 - Phillips Arena. This concert was postponed because Taylor had bronchitis.

1 October, 2011 - Phillips Arena.

2 October, 2011 - Phillips Arena.

18 April, 2013 - Phillips Arena.

19 April, 2013 - Phillips Arena.

24 October, 2015 - Georgia Dome.

10 August, 2018 - Mercedes-Benz Stadium.

11 August, 2018 - Mercedes Benz Stadium.

5 April, 2020 - Capital One Jam Fest (Centenial Olympic Park). Cancelled due to the worldwide COVID-19 pandemic.

28 April, 2023 - Mercedes-Benz Stadium.

29 April, 2023 - Mercedes-Benz Stadium.

30 April, 2023 - Mercedes-Benz Stadium.

Idaho (1).

Boise (1).

17 May, 2009 - Idaho Center.

Illinois (13).

Chicago (12).

9 October, 2009 - Allstate Arena.

10 October, 2009 - Allstate Arena.

9 August, 2011 - Allstate Arena.

10 August, 2011 - Allstate Arena.

10 August, 2013 - Soldier Field.

18 July, 2015 - Soldier Field.

19 July, 2015 - Soldier Field.

1 June, 2018 - Soldier Field.

2 June, 2018 - Soldier Field.

2 June, 2023 - Soldier Field.

3 June, 2023 - Soldier Field.

4 June, 2023 - Soldier Field.

Moline (1).

8 May, 2010 - i Wireless Center.

Indiana (9).

Indianapolis (8).

8 October, 2009 - Conseco Fieldhouse.

29 July, 2011 - Conseco Fieldhouse.

26 April, 2013 - Bankers Life Arena.

16 September, 2015 - Bankers Life Fieldhouse.

15 September, 2018 - Lucas Oil Stadium.

1 November, 2024 - Lucas Oil Stadium.

2 November, 2024 - Lucas Oil Stadium.

3 November, 2024 - Lucas Oil Stadium.

Evansville (1).

23 April, 2009 - Roberts Municipal Stadium.

Iowa (4).

Des Moines (4).

6 May, 2010 - Wells Fargo Arena.

29 May, 2011 - Wells Fargo Arena.

1 August, 2013 - Wells Fargo Arena.

8 October, 2015 - Wells Fargo Arena.

Kansas (2).

Wichita (2).

1 April, 2010 - Intrust Bank Arena.

6 August, 2013 - Intrust Bank Arena.

Kentucky (9, 1 postponed).

Lexington (4).

29 April, 2010 - Rupp Arena.

29 October, 2011 - Rupp Arena.

27 April, 2013 - Rupp Arena.

20 October, 2015 - Rupp Arena.

Louisville (5, 1 postponed).

30 August, 2009 - Kentucky State Fair (Freedom Hall).

2 July, 2011 - KFC Yum! Center. This concert was postponed because Taylor had bronchitis.

11 October, 2011 - KFC Yum! Center.

7 May, 2013 - KFC Yum! Center.

2 June, 2015 - KFC Yum! Center.

30 June, 2018 - Papa John’s Cardinal Stadium.

Louisiana (13).

Baton Rouge (2).

29 May, 2010 - Bayou Country Superfest (LSU Tiger Stadium).

22 May, 2015 - Baton Rouge, Louisiana (United States) - LSU Tiger Stadium.

Bossier City (3).

10 September, 2009 - CenturyTel Center.

20 September, 2011 - CenturyLink Center.

20 May, 2015 - CenturyLink Center.

Lafayette (1).

9 September, 2009 - Cajundome.

New Orleans (5).

5 October, 2011 - New Orleans Arena.

22 September, 2018 - Mercedes-Benz Superdome.

25 October, 2024 - Caesars Superdome.

26 October, 2024 - Caesars Superdome.

27 October, 2024 - Caesars Superdome.

Maryland (3).

Baltimore (1).

11 June, 2009 - Merriweather Post Pavillion.

Landover (2).

10 July, 2018 - FedEx Field.

11 July, 2018 - FedEx Field.

Massachusetts (13, 2 cancelled).

Foxborough (13, 2 cancelled).

5 June, 2010 - Gillette Stadium.

25 June, 2011 - Gillette Stadium.

26 June, 2011 - Gillette Stadium.

26 July, 2013 - Gillette Stadium.

27 July, 2013 - Gillette Stadium.

24 July, 2015 - Gillette Stadium.

25 July, 2015 - Gillette Stadium.

26 July, 2018 - Gilette Stadium.

27 July, 2018 - Gillette Stadium.

28 July, 2018 - Gillette Stadium.

31 July, 2020 - Lover Fest East (Gilette Stadium). Cancelled due to the worldwide COVID-19 pandemic.

1 August, 2020 - Lover Fest East (Gilette Stadium). Cancelled due to the worldwide COVID-19 pandemic.

19 May, 2023 - Gillette Stadium.

20 May, 2023 - Gillette Stadium

21 May, 2023 - Gillette Stadium.

Michigan (10).

Detroit (8).

26 March, 2010 - The Palace of Auburn Hills.

27 March, 2010 - The Palace of Auburn Hills.

11 June, 2011 - Ford Field.

4 May, 2013 - Ford Field.

30 May, 2015 - Ford Field.

28 August, 2018 - Ford Field.

9 June, 2023 - Ford Field.

10 June, 2023 - Ford Field.

Grand Rapids (2).

2 October, 2009 - Van Andel Arena.

28 July, 2011 - Van Andel Arena.

Minnesota (15).

Detroit Lakes (1).

7 August, 2009 - WE Fest (Soo Pass Ranch).

Duluth (1).

3 September, 2009 - Arena at Gwinett Center.

Minneapolis/St. Paul (13).

11 October, 2009 - Target Center.

7 May, 2010 - Xcel Energy Center.

14 June, 2011 - Xcel Energy Center.

15 June, 2011 - Xcel Energy Center.

7 September, 2013 - Xcel Energy Center.

8 September, 2013 - Xcel Energy Center.

11 September, 2015 - Xcel Energy Center.

12 September, 2015 - Xcel Energy Center.

13 September, 2015 - Xcel Energy Center.

31 August, 2018 - U.S. Bank Stadium.

1 September, 2018 - U.S. Bank Stadium.

23 June, 2023 - U.S. Bank Stadium.

24 June, 2023 - U.S. Bank Stadium.

Mississippi (1).

Biloxi (1).

2 May, 2009 - Mississippi Coast Coliseum.

Missouri (17, 2 postponed).

Kansas City (9).

2 April, 2010 - Sprint Center.

24 September, 2011 - Arrowhead Stadium.

2 August, 2013 - Sprint Center.

3 August, 2013 - Sprint Center.

21 September, 2015 - Sprint Center.

22 September, 2015 - Sprint Center.

8 September, 2018 - Arrowhead Stadium.

7 July, 2023 - GEHA Field at Arrowhead Stadium.

8 July, 2023 - GEHA Field at Arrowhead Stadium.

St. Louis (8, 2 postponed).

25 April, 2009 - Scottrade Center.

13 August, 2011 - Scottrade Center.

14 August, 2011 - Scottrade Center.

18 March, 2013 - Scottrade Center.

19 March, 2013 - Scottrade Center.

28 September, 2015 - Scottrade Center.

29 September, 2015 - Scottrade Center.

13 October, 2015 - St. Louis, Missouri (United States) - Scottrade Center. Postponed and moved forward by a month after Houston was added to the schedule.

Originally, the St. Louis shows downsized from two to one after Houston was added but the second show was added again due to overwhelming demand.

14 October, 2015 - St. Louis, Missouri (United States) - Scottrade Center. Postponed and moved forward by a month after Houston was added to the schedule.

Originally, the St. Louis shows downsized from two to one after Houston was added but the second show was added again due to overwhelming demand.

18 September, 2018 - The Dome of America’s Center.

Nebraska (7).

Omaha (7).

9 August, 2009 - Qwest Center.

27 May, 2011 - Qwest Center.

28 May, 2011 - Qwest Center.

13 March, 2013 - CenturyLink Center.

14 March, 2013 - CenturyLink Center.

9 October, 2015 - CenturyLink Center.

10 October, 2015 - CenturyLink Center.

Nevada (4).

Las Vegas (4).

23 May, 2009 - Mandalay Bay Events Center.

15 May, 2015 - Rock In Rio (Las Vegas Festival Grounds).

24 March, 2023 - Allegiant Stadium.

25 March, 2023 - Allegiant Stadium.

New Jersey (18).

East Rutherford (9).

13 July, 2013 - MetLife Stadium.

10 July, 2015 - Metlife Stadium.

11 July, 2015 - MetLife Stadium.

20 July, 2018 - Metlife Stadium.

21 July, 2018 - MetLife Stadium.

22 July, 2018 - MetLife Stadium.

26 May, 2023 - Metlife Stadium.

27 May, 2023 - Metlife Stadium.

28 May, 2023 - MetLife Stadium.

Newark (9).

12 May, 2010 - Prudential Center.

13 May, 2010 - Prudential Center.

19 July, 2011 - Prudential Center.

20 July, 2011 - Prudential Center.

23 July, 2011 - Prudential Center.

24 July, 2011- Prudential Center.

27 March, 2013 - Prudential Center.

28 March, 2013 - Prudential Center.

29 March, 2013 - Prudential Center.

New York (6).

Buffalo (1).

21 June, 2011 - HSBC Arena.

New York City (3).

27 August, 2009 - Madison Square Garden.

21 November, 2011 - Madison Square Garden.

22 November, 2011 - Madison Square Garden.

Uniondale (2).

14 May, 2010 - Nassau Veterans Memorial Coliseum.

15 May, 2010 - Nassau Veterans Memorial Coliseum.

North Carolina (10, 1 postponed).

Charlotte (3, 1 postponed).

5 September, 2009 - Time Warner Cable Arena.

8 July, 2011 - Time Warner Cable Arena. This concert was postponed because Taylor had bronchitis.

16 November, 2011 - Time Warner Cable Arena.

22 March, 2013 - Time Warner Cable Arena.

Raleigh (2).

13 September, 2013 - PNC Arena.

9 June, 2015 - PNC Arena.

Greensboro (5).

12 June, 2009 - Greensboro Coliseum.

30 June, 2011 - Greensboro Coliseum.

12 September, 2013 - Greensboro Coliseum.

13 September, 2013 - Greensboro Coliseum.

21 October, 2015 - Greensboro Coliseum.

North Charleston (1).

30 April, 2009 - North Charleston Coliseum.

Raleigh (2).

1 May, 2010 - RBC Center.

17 November, 2011 - RBC Center.

North Dakota (3).

Fargo (2, 1 postponed).

6 September, 2013 - Fargodome.

9 September, 2015 - Fargodome. This concert was postponed and swapped with the concert in Houston in case the MLB team the Houston Astros needed Minute Maid Park for the 2015 baseball post season.

12 October, 2015 - Fargodome.

Minot (1).

25 July, 2009 - North Dakota State Fair (North Dakota State Fair Grandstand).

Ohio (14).

Cincinatti (3).

28 March, 2010 - U.S. Bank Arena.

30 June, 2023 - Paycor Stadium.

1 July, 2023 - Paycor Stadium.

Cleveland (5).

3 October, 2009 - Quicken Loans Arena.

30 July, 2011 - Quicken Loans Arena.

25 April, 2013 - Quicken Loans Arena.

3 June, 2015 - Quicken Loans Arena.

17 July, 2018 - Cleveland, Ohio (United States) - First Energy Stadium.

Columbus (6).

17 July, 2009 - Value City Arena.

7 June, 2011 - Nationwide Arena.

8 May, 2013 - Nationwide Arena.

17 September, 2015 - Nationwide Arena.

18 September, 2015 - Nationwide Arena.

7 July, 2018 - Ohio Stadium.

Oklahoma (5).

Oklahoma City (2).

31 March, 2010 - Ford Center.

15 October, 2011 - Chesapeake Arena.

Tulsa (3).

27 September, 2009 - BOK Center.

21 September, 2011 - BOK Center.

7 August, 2013 - BOK Center.

Oregon (3).

Portland (3).

16 May, 2009 - Rose Garden Arena.

6 September, 2011 - Rose Garden Arena.

30 August, 2013 - Moda Center.

Pennsylvania (20).

Philadelphia (12).

18 March, 2010 - Wachovia Center.

19 March, 2010 - Wachovia Center.

6 August, 2011 - Lincoln Financial Field.

19 July, 2013 - Lincoln Financial Field.

20 July, 2013 - Lincoln Financial Field.

12 June, 2015 - Lincoln Financial Field.

13 June, 2015 - Lincoln Financial Field.

13 July, 2018 - Lincoln Financial Field,

14 July, 2018 - Lincoln Financial Field.

12 May, 2023 - Lincoln Financial Field.

13 May, 2023 - Lincoln Financial Field.

14 May, 2023 - Lincoln Financial Field.

Pittsburgh (7).

1 October, 2009 - Mellon Arena.

18 June, 2011 - Heinz Field.

6 July, 2013 - Heinz Field.

6 June, 2015 - Heinz Field.

7 August, 2018 - Heinz Field.

16 June, 2023 - Acrisure Stadium.

17 June, 2023 - Acrisure Stadium.

University Park (1).

29 August, 2009 - Bryce Jordan Center.

South Carolina (4).

Columbia (3).

30 April, 2010 - Colonial Life Arena.

18 November, 2011 - Colonial Life Arena.

23 March, 2013 - Colonial Life Arena.

Greenville (1).

4 September, 2009 - BI-LO Center.

South Dakota (1).

Rapid City (1).

24 July, 2009 - Rushmore Plaza Civic Center.

Tennessee (14).

Knoxville (1).

1 July, 2011 - Thompson-BolingArena.

Memphis (1).

30 October, 2011 - FedEx Forum.

Nashville (12).

12 September, 2009 - Sommet Center.

16 September, 2011 - Bridgestone Arena.

17 September, 2011 - Bridgestone Arena.

19 September, 2013 - Bridgestone Arena.

20 September, 2013 - Bridgestone Arena.

21 September, 2013 - Bridgestone Arena.

25 September, 2015 - Bridgestone Arena.

26 September, 2015 - Bridgestone Arena.

25 August, 2018 - Nissan Stadium.

5 May, 2023 - Nissan Stadium.

6 May, 2023 - Nissan Stadium.

7 May, 2023 - Nissan Stadium.

Texas (26, 1 postponed).

Arlington/Dallas (10).

25 September, 2009 - American Airlines Center.

11 March, 2010 - American Airlines Center.

8 October, 2011 - Cowboys Stadium.

25 May, 2013 - Cowboys Stadium.

17 October, 2015 - AT&T Stadium.

5 October, 2018 - AT&T Stadium.

6 October, 2018 - AT&T Stadium.

31 March, 2023 - AT&T Stadium.

1 April, 2023 - AT&T Stadium.

2 April, 2023 - AT&T Stadium.

Austin (3).

10 March, 2010 - Frank Erwin Center.

26 October, 2011 - Frank Erwin Center.

21 May, 2013 - Frank Erwin Center.

Corpus Christi (1).

12 March, 2010 - American Bank Center Arena.

Houston (9).

25 May, 2010 - Toyota Center.

26 May, 2010 - Toyota Center.

5 November, 2011 - Minute Maid Park.

16 May, 2013 - Toyota Center.

9 September, 2015 - Minute Maid Park.

12 October, 2015 - Minute Maid Park. This concert was postponed and swapped with the concert in Fargo in case the MLB team the Houston Astros needed Minute Maid Park for the 2015 baseball post season.

29 September, 2018 - NRG Stadium.

21 April, 2023 - NRG Stadium.

23 April, 2023 - NRG Stadium.

22 April, 2023 - NRG Stadium.

Lubbock (1).

14 October, 2011 - United Spirit Arena.

San Antonio (2).

25 October, 2011 - AT&T Center.

22 May, 2013 - AT&T Center.

Utah (4).

Salt Lake City (4).

26 May, 2009 - EnergySolutions Arena.

28 September, 2011 - EnergySolutions Arena.

1 June, 2013 - EnergySolutions Arena.

4 September, 2015 - EnergySolutions Arena.

Virginia (2).

Charlottesville.

20 March, 2010 - John Paul Jones Arena.

14 September, 2013 - John Paul Jones Arena

Washington (8).

Seattle/Tacoma (7).

15 May, 2009 - KeyArena.

7 September, 2011 - Tacoma Dome.

31 August, 2013 - Tacoma Dome.

8 August, 2015 - CenturyLink Field.

22 May, 2018 - CenturyLink Field.

22 July, 2023 - Lumen Field.

23 May, 2023 - Lumen Field.

Spokane (1).

14 May, 2009 - Spokane Veterans Memorial Arena.

Washington, DC (8).

1 June, 2010 - Verizon Center.

2 June, 2010 - Verizon Center.

2 August, 2011 - Verizon Center.

3 August, 2011 - Verizon Center.

11 May, 2013 - Verizon Center.

12 May, 2013 - Verizon Center.

13 July, 2015 - Nationals Park.

14 July, 2015 - Nationals Park.

West Virginia (1).

Charleston (1).

18 July, 2009 - Charleston Civic Center.

Wisconsin (4).

Cadott (1).

25 June, 2009 - Country Fest 2009 (Chippewa Valley Festival Grounds).

Milwaukee (1).

8 June, 2011 - Bradley Center.

Oshkosh (1).

24 June, 2009 - Country USA Festival (Ford Festival Park).

Twin Lakes (1).

16 July, 2009 - Country Thunder Festival (Shadow Hill Ranch).

Wyoming (1).

Cheyenne (1).

23 July, 2009 - Cheyenne Frontier Days Arena.

Wales (1).

Cardiff (1).

18 June, 2024 - Principality Stadium.

#Taylor Swift #Fearless Tour #Speak Now World Tour #Red Tour #1989 World Tour #reputation Stadium Tour #Lover Fest #Eras Tour

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irishprematurebabies · 2 years ago

Photo

https://www.hippocraticpost.com/australasia/stillborn-and-preterm-statistics-for-covid-19-first-wave/ Interesting research. The research of 52 million births from 26 countries, published in Nature Human Behavior, reported a 3-4 per cent reduction overall in preterm births, averting almost 50,000 preterm pregnancies during the first month of lockdown alone. But the decrease in preterm births was limited to only high-income countries including Australia. The International Perinatal Outcomes in the Pandemic (iPOP) Study, one of the largest such studies of its kind, involved 167 collaborators across 42 countries. Murdoch Children’s Research Institute co-led the project alongside The Children’s Hospital Research Institute of Manitoba, University of Manitoba, The University of Edinburgh and UNSW Sydney. #preemiefamily #preterm #prematurebabiesawareness #neonatolgy #neonatal #prematurity #earlybaby #earlybabies #premature #research #nicuparents #nann #NICU https://www.instagram.com/p/Cpvrxnaqzb2/?igshid=NGJjMDIxMWI=

#preemiefamily #preterm #prematurebabiesawareness #neonatolgy #neonatal #prematurity #earlybaby #earlybabies #premature #research #nicuparents #nann #nicu

8 notes · View notes

keeshplay · 1 year ago

Text

Except we've known about such savings for YEARS.

And we know how minimal income helps people.

We know, factually, over and over again, that giving people money to cover basic needs and to get themselves out of holes, is beneficial across the board. It saves money in multiples support systems because they can focus on those who truly need more complex assistance.

Our leaders just chose to ignore it.

Source

55K notes · View notes

preparefirstaidtraining · 14 hours ago

Text

The Importance of Proper First Aid and HCP Courses Winnipeg

As the largest city in Manitoba, Winnipeg sees its fair share of medical emergencies that require immediate first aid response. Having citizens properly trained in first aid and HCP Courses Winnipeg can help save lives when urgent situations occur. Getting the right training from a reputable provider is crucial for residents of Winnipeg to gain these potentially lifesaving skills.

In Winnipeg, first aid and HCP courses Winnipeg are offered by organizations like the Canadian Red Cross and St. John Ambulance. These nationally recognized training bodies have extensive experience in teaching evidence-based first aid protocols to millions of people across Canada. By taking a course with them in Winnipeg, you can trust you’ll get top-quality instruction that meets provincial and national standards.

But why is it so vital for Winnipeg residents specifically to get this type of training? Here are a few key reasons:

Extreme Weather Emergencies

As a city prone to long, bitterly cold winters, Winnipeg sees its fair share weather-related emergencies. These can range from people suffering from hypothermia or frostbite to vehicle accidents caused by icy roads. Having citizens trained to provide initial care in these types of emergencies until EMS arrives could save lives and prevent further injury or illness.

Influx of Refugees & Newcomers

As Manitoba continues to welcome new waves of immigrants and refugees, it’s essential that existing residents have adequate first aid skills to support the health and safety needs of our changing population. Taking a course to refresh your knowledge ensures you’ll be prepared to assist someone newly arrived in Winnipeg if an emergency occurs.

Aging Population

With the large baby boomer population now entering their senior years, the number of citizens vulnerable to health issues like heart problems, falls, and other emergencies will continue rising over the coming decade. Getting trained helps equip younger citizens with the ability to support this vulnerable group if a crisis situation emerges.

Rise of Public Health Emergencies

Events like the COVID-19 pandemic have demonstrated how essential it is for citizens to have robust First Aid Training Winnipeg in order to protect themselves and support their community during public health threats. Learning the infection control procedures and personal safety requirements covered in these courses will keep residents prepared for the next large-scale threat that arises.

And while major cities like Winnipeg have emergency medical services that provide rapid response in crisis situations, bystanders trained in first aid and HCP protocols are often first on the scene when an incident occurs. So, getting certified gives residents the ability to act immediately and deliver care until EMS teams arrive to take over.

Key Skills Covered in Winnipeg HCP & First Aid Courses

So, what are some of the vital skills you’ll gain by taking a first aid or HCP Courses Winnipeg? Here are some of the important areas typically covered:

Recognizing the signs and symptoms of urgent medical issues like heart attacks, strokes, anaphylaxis, and hyperglycemia

Conducting key checks for key vital signs like patient responsiveness, pulse, and breathing

Applying CPR and using an automated external defibrillator (AED) to treat cardiac arrest victims

Controlling major bleeding from wounds using dressings and tourniquets

Treating issues ranging from choking, fractures or sprains, and shock

Implementing universal safety precautions to limit disease transmission risk

On the HCP course side specifically, advanced skills like administering emergency oxygen and assisting patients with using inhalers or epinephrine auto-injectors will also be covered. This provides a more enhanced scope of emergency care compared to standard first aid.

Where to Take an HCP or First Aid Training Winnipeg

Now that you grasp the importance of getting certified, where exactly can you take a course in the city? Here are your main options for trusted providers:

The Canadian Red Cross has branches located throughout Winnipeg where their certified first aid and HCP instructors deliver emergency care training that’s accredited nationally. Plus, they offer both classroom-based and online blended courses for added flexibility.

Independent trainers certified by the Lifesaving Society provide another avenue to pursue first aid or HCP Courses Winnipeg. They offer private group/workplace courses along with open enrollment sessions advertised on sites like Eventbrite.

Regardless of which training provider you ultimately select in Winnipeg, taking that first step get certified in first aid or HCP could one day make all the difference in saving a life when seconds matter most. It’s one of the best investments you can make to keep yourself, your family, and fellow community members safe.

#HCP Courses Winnipeg #CPR Courses Winnipeg #First Aid Training Winnipeg #AED Training Winnipeg #CPR Training Winnipeg

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wavevisas123 · 2 months ago

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Annual Study Shows Decline in Immigration Support for Second Consecutive Year

Table of Contents

Overview

An Overview of Immigration Trends in Canada

Current Canadian Trends Immigration

New Information on Immigration to Canada

The Effects of the Economic Recovery on Visa Consultancy Services

Recognizing Public Opinion

Regional Variations in Immigration Support for Canada

Changes in Attitudes Toward Immigration by Generation

Immigration Consultants’ Function

Canadian Immigration Consultants’ Significance in Visa Procedures

Advantages of Hiring the Top Immigration Advisors for Your Process

Opportunities for Education Abroad

Pursuing Education in Canada as a Route to Long-Term Residence

International Students’ Attraction to Canadian Educational Institutions

Resolving Economic Issues

Views on Immigration to Canada and Its Effect on the Economy

Positive Attitudes Toward Immigration Across Various Populations

In conclusion

Keeping Public Opinion and Immigration Sentiment in Check

Promoting Assistance for Upcoming Immigration Routes to Canada

Recognizing Canada's Changing Landscape Immigration

Canada has long been renowned for its hospitable immigration policies, drawing people from all over the world with the promise of opportunity and a good standard of living. But according to recent research from the Environics Institute, support for high immigration levels has significantly decreased, falling to its lowest level in 25 years. Important considerations concerning the future of immigration to Canada and its effects on the labor and education are brought up by this change.

Immigration Trends in Canada Right Now

The immigration situation in Canada seems to be drastically shifting in 2024. Sixty percent of Canadians think the nation is taking in too many immigrants, according to the Environics survey. Comparing this to prior years, when support for immigration had peaked following the COVID-19 epidemic, shows a marked increase in negative attitude.

There are a number of reasons for this reduction. Many Canadians are starting to reevaluate their immigration policies as unemployment rates are starting to rise as the country's economy recovers from the epidemic, having recovered 138% of the jobs lost. Updates to the Immigration Levels Plan and restrictions on international students are two examples of how these economic changes are influencing immigration laws.

Being Aware of Public Opinion

63% of respondents in Alberta and 68% in Manitoba and Saskatchewan expressed concerns about high immigration levels, indicating that support for immigration is noticeably lower in the Prairie provinces, according to the study data. Curiously, unfavorable feelings rise more sharply among Canadians under 45 than among older populations. This shows that opinions on immigration are changing across generations.

The fact that most Canadians still acknowledge the advantages that some forms of immigration offer the nation should not be overlooked in spite of their reservations. According to nearly three-quarters of respondents, new hires with highly sought-after talents are given preference. According to this, Canadians continue to value the contributions of educated newcomers and talented workers despite concerns about the overwhelming number of immigration.

Immigration Consultants' Function

It can be difficult to navigate the complicated immigration landscape in Canada, thus many potential immigrants seek advice from Canadian immigration consultants. These professionals offer insightful information about the different immigration routes to Canada, such as work visas, student permits, and family reunification choices.

Visa consulting services are essential for assisting people in comprehending the prerequisites and procedures for acquiring the required paperwork. The top immigration advisors can help expedite the process and increase the likelihood of success for everything from obtaining a work visa to applying for a study permit under the new regulations.

Opportunities for Education Abroad

Studying in Canada appeals to a lot of people since it's frequently thought of as a route to permanent residency. Only 27% of respondents prioritized international students in the most recent study, indicating a drop in support for this group of immigrants. Nevertheless, because of the excellent education and multicultural setting, studying in Canada is still a popular option for overseas students.

Numerous programs are available in Canadian educational institutions to accommodate a wide range of interests and professional goals. Attending a Canadian university or college improves a student's employability in a competitive job market in addition to offering them a top-notch education. Additionally, many foreign students view studying in Canada as a strategic step towards attaining permanent residency.

Resolving Economic Issues

It's crucial to note that many Canadians still have a positive opinion of immigration, even though a sizable section of the populace believes that immigration is a contributing reason to economic difficulties. The national economy benefits from immigration, according to almost 70% of respondents. People with more education and those who favor the Liberal and NDP parties are particularly likely to feel this way.

Addressing worries about how immigration will affect jobs and resources will be essential as the Canadian economy develops. It is possible to change public perception and draw attention to the beneficial contributions immigrants make to the economy and society by holding candid conversations and offering data-driven insights.

In conclusion

The recent shift in attitudes toward immigration to Canada is a reflection of larger social and economic patterns. Fostering a balanced perspective that acknowledges the advantages immigrants bring to the nation is crucial as Canadians struggle with worries about immigration levels and their effects.

Consulting with knowledgeable Canadian immigration advisors can help anyone thinking about moving to Canada understand and navigate the application process. Although they are being examined more closely, the routes to immigration are still open, whether it is through skilled employment possibilities or studies in Canada. By comprehending these relationships, people and legislators can collaborate to establish a welcoming and constructive atmosphere for everybody.

If you're looking for assistance with your immigration journey, consider reaching out to experienced visa consultancy services. They can help you explore your options and make your dream of moving to Canada a reality.

Looking for Canada immigration ? Click on the below mentioned link.

#immigrationservices #consultant #wavevisas #consultantservice #canadaimmigration

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allthecanadianpolitics · 1 year ago

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Two Alberta lawyers charged with attempting to obstruct justice have been banned from practising law anywhere in Canada for three years as part of a plea deal with Manitoba prosecutors that saw their charges stayed.

Randal Jay Cameron and John Carpay were also charged with intimidation of a justice system participant after they hired a private investigator to follow the Manitoba judge who presided over their case challenging COVID-19 restrictions in 2021.

Full article

Tagging: @politicsofcanada

#cdnpoli #canada #canadian politics #canadian news #canadian #randal jay cameron #john carpay #obstruction of justice #intimidation #coronavirus restrictions #COVID-19 restrictions #alberta #manitoba

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sutrala · 4 months ago

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(NaturalNews) TheÂ Public Health Agency of Canada (PHAC) has ordered provinces to destroy Pfizer and Moderna Wuhan coronavirus (COVID-19) mRNA vaccine vials...

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covid-safer-hotties · 4 months ago

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Health Canada orders provinces to destroy old COVID-19 vaccines amid wait for new batch - Published Sept 4, 2024

Health Canada has directed provinces to withdraw and destroy remaining supplies of last year's COVID-19 vaccines while it works to authorize updated shots, which is expected to happen in October, according to Ontario’s health ministry.

“Vaccines will be available once Ontario receives supply from Health Canada following their regulatory authorization of the new, updated vaccine formulation," read a statement from Ontario spokesperson Hannah Jensen.

A notice posted on the federal government’s immunization guide says vaccines aimed at Omicron variant XBB.1.5 is no longer available in Canada. Updated shots, made to target the now-dominant JN.1 or KP.2 strains are expected to get the green light “in the coming weeks.”

Meanwhile, COVID-19 is spreading quickly and widely across Canada, wastewater sampling and test positivity rates suggest.

Alberta's health ministry has confirmed old-strain COVID-19 vaccines are no longer available. Quebec’s public health director told CTV News current stockpiles are to be returned to Ottawa. Saskatchewan has disposed of their Moderna Spikevax XBB.1.5 and Pfizer Comirnaty XBB.1.5 vaccines in anticipation of new doses.

"It is estimated Ontario, and other provinces, will receive supply from Health Canada in October," Jensen added.

CTV News has sought further comment from Health Canada on what it will do to remedy what appears to be a widespread gap in access to vaccines. The agency told CTV News Calgary that the swap should be timed so that there is uninterrupted access to shots.

In a statement, a spokesperson told CTVNews.ca that public health is working on a vaccine transition plan with provinces and territories, adding that it’s in talks with those governments “to ensure common understanding of the transition.”

The agency also says it maintains a federal reserve of XBB vaccines to respond to “any unexpected health need.”

COVID-19 spreading fast While regional and federal governments have largely scaled down their surveillance on the spread of COVID-19, national wastewater sampling suggests the virus remains active throughout the country.

“The viral activity level of COVID-19 is high,” reads Canada’s Wastewater monitoring dashboard. Regional sampling reveals a high level of viral activity in B.C., Saskatchewan, Manitoba, Ontario, Nova Scotia, and Newfoundland and Labrador.

The spread in Yukon, Alberta and Quebec is described as “moderate.” There is no data available for the Northwest Territories nor Nunavut.

The COVID-19 test positivity rate was 18 per cent for the week of Aug. 24 – it’s highest since early December 2023 when Canada had begun its descent from a wintertime wave of infections.

#covid #mask up #pandemic #covid 19 #wear a mask #coronavirus #sars cov 2 #public health #still coviding #wear a respirator

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didanawisgi · 8 months ago

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#covid-19 vaccine #covid-19

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ivftreatmentcostpaloalto · 8 months ago

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San Francisco Egg Freezing: A Comprehensive Cost Analysis

CHA Fertility Center includes a renowned, holistic reproductive clinic in Los Angeles, CA. This Los Angeles Fertility workplace supplies superior Fertility treatment including Ovulation Induction, Artificial Insemination, IUI, Frozen Embryo Transfers, ICSI, PGS, IVF, and 360° Total VIP Care services click here.

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Affected Person Satisfaction / Expertise

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How Do Success Rates Impact Total Costs?

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The clinic provides an array san francisco egg freezing the most effective services and has excessive fertility and IVF success charges in the CA fertility business.

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Egg Freezing Procedures

Like having your future kids sit back next to your ice cream till the time is correct. You’re wondering how a lot is IVF treatment, and egg retrieval particularly, going to ding your wallet? A huge a part san francisco egg freezing that equation is whether or not your insurance will foot the bill.

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At What Age Ought To I Freeze My Eggs?

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One ovary will possibly have a higher count than the other ovary. Regardless, this establishes a baseline which they may reference when you’re ready for remedy. Note you could nonetheless freeze your eggs if you're on some type san francisco egg freezing contraception. However, the physician will ask you to cease prior to your therapy.

#San Francisco Egg Freezing #Youtube

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