#c: jc 001

[nyraxodeyer]

for: @icexpackxjc location: anywhere

After having reassured both the Mahir's and Mehta's that they were doing all they could to find Dhruv, and checking in on the fae to see how they were, next on Nyra's list was meeting up with JC, he own recovery took a back seat given everything that has happened since Saturday and really that was not ever something she would focus on, not when two people close to her were taken. A million things raced through her mind, all leading to more questions than answers but there was no time to waste and let worrying thoughts freeze her to a complete standstill.

Fluttering to a stop near JC, her wings drew to a close as she looked over to him, knowing this was personal for him too, "How are you getting along?" After a beat, she spoke again, relaying what she had gathered, "Unfortunately, his family hadn't seen him much, occasional drop by after work but he mostly seemed to have stayed to his apartment." Dhruv had not been part of the riddles she had found later on, him like Meena seemed to have been taken separately, and somewhere else too that the rest of the kidnapped folk were not. "The full moon is soon, when Dhruv shifts would you be able to reach him through pack bond? Maybe him and Meena had been taken to the same place? Aaliyah might be able to tell us if clan telepathy struck luck."

[jonahxrivas]

for: @jcgustavo location: ice rink

Even if time waited for no one to tick away, Jonah felt as though he had not moved since, what everyone had taken to call, the scavenger hunt. A horrid name even if he had admit the word was rather true. Work kept him busy even if he felt like he was running on auto-pilot, but the routine of it was not as fun as it used to be and the repetitive tasks allowed space for thoughts to sneak in and render him useless while his mind went on unsanctioned journeys. Responsibilities outside of work demanded attention but he pushed everything to the back of his mind and in a very selfish move looked for other ways he could to distract himself, other ways to give his brain something entirely new to focus on. Ice Skating was just that ridiculous idea. Jonah stepped in thinking this was perfect. 

Jonah almost walked out again as the notion of how ridiculous this was hit him. Having tried it out around Christmas last year and having fallen numerous times, why would this be good? Second guessing was second nature when it came to things outside what he was used to, but before he could act on that thought, autopilot mode activated and he found himself already lacing up his skates. At least this stopped him walking away but wobbling as he entered the rink, the countdown to him falling ended a minute later. “Work for me” he pleaded as he remained seated on the ice, “You’re just frozen water… why are you being difficult...”

[dvsconocvdo]

closed starter for @icexpackxjc

"Fancy seeing you here." Noel joked as she walked around the outskirts of the ice rink. She had fully sought JC out, but there was no fun in admitting that. After the lunar eclipse in October, she had a few questions about shifting, but she felt a bit sheepish for not knowing better. Being a werewolf was still so new, and it was still so hard to control it. (The broken door handles were piling up in her place). Still, she needed to get answers to see if she could calm herself a bit with another full moon approaching later in the month. "Are you busy right now? I don't want to interrupt any of your classes."

[greetingsfromnashville]

....GREETINGS FROM NASHVILLE. MUSIC CITY WELCOMES YOU.

Without further ado - here are our acceptances. We are truly overwhelmed by the interest in this RP, and thank you endlessly for your patience. You’ll see below which plots have been assigned to your character(s). 

We tried very hard to make sure that we could give everyone the plots they chose, but we ended up with a lot of overlap between plots that had several first choice applications, but those were also backups to several players. Who knew how many muses were prone to having bad days at coffee shops?

There are some muses that we will require additional plots from - meaning you applied to start with 2 but we were unable to find 2 that fit for you. Everyone has at least 1 that was a first choice or backup choice! I apologize if anyone is disappointed with the plots they have been given, or not receiving your first choice, but, again, we did make sure that every plot assigned to every player was in your primary or backup choice. If you’ve been asked to submit a new plot choice, we plan to post a new batch of plots this weekend, so you may select something now or wait until these new plots are posted.

Regardless, we are now ready to receive accounts, so please see the NEW MEMBER CHECKLIST and when you are ready, submit your accounts to the main. We open for interaction tomorrow and will make an announcement when we are ready to do so.

ACCEPTANCES UNDER THE READ MORE

ABRAMS, ADDISON ( alex ) 

STORY 001, MUSE A + STORY 009, MUSE A

ANDERSON, BLAINE ( audra ) 

STORY 013, MUSE A + STORY 037, MUSE B

ANDERSON, DAVLIN ( j )

STORY 026, MUSE A + STORY 045, MUSE B

CLAINGTON, JAMIE ( rebel )

STORY 027, MUSE A + STORY 035, MUSE B

EVANS, SAM ( jc ) 

STORY 031, MUSE B + STORY 046, MUSE B

EVANS, STACIE ( katy )

STORY 020, MUSE A + STORY 042, MUSE A

FABRAY, BENJAMIN ( meg )

STORY 007, MUSE B + STORY 024, MUSE B

FABRAY, BRIANNA ( holly )

STORY 014, MUSE B + STORY 048, MUSE A

HARPER, DANI ( ellie )

STORY 043, MUSE A

HARPER, RAFAEL ( meg )

STORY 023, MUSE A + STORY 040, MUSE B

HUDSON, FINN ( t )

STORY 017, MUSE B + STORY 047, MUSE A

HUMMEL, EVELYN ( justine )

STORY 041,MUSE B + STORY 050, MUSE B

HUMMEL, KURT ( j )

STORY 003, MUSE C + STORY 025, MUSE A

JONES, MERCEDES ( tori ) 

STORY 022, MUSE A + STORY 046, MUSE A

LOPEZ, SANTANA ( a )

STORY 004, MUSE A + STORY 029, MUSE A

LYNN, ALEJANDRO ( autumn )

STORY 044, MUSE A

MCCARTHY, MASON ( heather )

STORY 014, MUSE C + STORY 040, MUSE C

ROSE, DYLAN ( jc )

STORY 016, MUSE B + STORY 040, MUSE A

ROSE, MARLEY ( emily ) 

STORY 018, MUSE A + STORY 039, MUSE B

ROSE, SYDNEY ( jordan )

STORY 022, MUSE B + STORY 035, MUSE A

RUTHERFORD, IMANI ( jordan ) 

STORY 009, MUSE B + STORY 021, MUSE A

SMYTHE, LIBBY ( ellie ) 

STORY 002, MUSE B

SMYTHE, MATHIEU ( alex ) 

STORY 31, MUSE A + STORY 036, MUSE A

SMYTHE, SEBASTIAN ( autumn ) 

STORY 049, MUSE A

WESTON, WILLA ( brie )

STORY 016, MUSE A

WILDE, ARI ( aly )

STORY 005, MUSE B + STORY 008, MUSE A

INDIVIDUALS FROM WHICH WE NEED NEW CHOICES FOR PLOTS

The following accounts are accepted, however you have the option to pick a new plot now or have first choice when a new batch is dropped this weekend. Please let us know your choice.

EVANS, STEVEN ( tj )

STORY 028, MUSE A

GUNNFULSEN, JOSEPHINE ( sarah )

STORY 043, MUSE B

JOHNSON, CASSANDRA ( shers )

STORY 034, MUSE A

MCCARTHY, PENELOPE ( elise )

STORY 023, MUSE B

PORTER, WANDA ( ale )

STORY 017, MUSE A

If we do require some changes to family details, we will be messaging you directly to receive this information from you.

Again, thank you all so much. 

[ofbloodandsnow]

"Oh, I'll bet." He murmured, slowly coming closer. "Weird... is not the word I'd use. I feel good." Hungry. "Do we not look good?" He waved at his fellow people, shadow-eyed vampires and witches vaguely milling about the scene. He quirked a brow at the man's comment. Cute? "And here I was thinking Sleeping Beauty? But I suppose that'd make me royalty, hmm?" He certainly felt like royalty. "I don't suppose you would take your own advice?"

JC narrowed his eyes, ridged brow furrowing. "My bite's worse than my bark, guy. I don't think you'd wanna see me use them close-up. Splash zone." He truly had no intention of tearing into any vampires tonight, aware of the goddam international incident such a thing would cause, but the wolf also had no intention of letting down his guard with whatever chaos was unfurling. "Fun, huh? Not feeling weird or anything?" At this point, Júlio César did not quite know what was affecting the people around him, but he had seen enough goddamn television to know blackened irises were likely not wholesome and fuzzy. "Cute. Never heard that one before. Maybe you wanna sit down and take a nap yourself or something. But that's Goldilocks, isn't it?"

[innspubnet]

By: PO Mongare, JR Okalebo, CO Othieno, JO Ochuodho, AK Kipkoech, AO Nekesa

Key Words: Survey, Soil fertility technologies, Adoption

Int. J. Agron. Agri. Res. 15(6), 1-9, December 2019.

Certification: ijaar 2019 0199 []

Download Certificate

Abstract

A survey on adoption levels of the existing soil nitrogen replenishing technologies amongst farmers in three counties in western Kenya was carried out in June 2011. Three farmer associations were Angurai Farmers Development Project (AFDEP), Bungoma Small-Scale Farmers Forum (BUSSFFO) and Mwangaza Farmer Group (MFAGRO). During the survey 223 farmers were interviewed with roughly a half of the households surveyed being members of farmer associations (FAs) and the other half being non-members, who acted as the control. Stratified random sampling technique was used. A repeated measures Analysis of Variance (RM – ANOVA) showed that various soil nitrogen replenishment technologies were adopted to various degrees, F (4.39, 855.43) =23.36, p<.001). The findings of this study indicated that the available technologies most extensively used in the study area were the use of inorganic fertilisers (DAP), planting of improved legumes processing, Lab lab, Push Pull, and Super 2 Package. In second place, were technologies such as seed inoculation, foliar feed use, top dressing fertiliser (CAN) and use of improved legumes. The least used technologies were found to be Ua Kayongo (IR seed), MBILI intercropping, fortified compost, and use of Farm yard manure and liming. The results also indicated that generally, adoption of technologies was higher amongst farmer association members compared with non-members regardless of the county. Bungoma County had significantly highest level of technology adoption level compared to both Busia and Vihiga. Adoption of soil technologies was also found to be positively correlated with farmers’ educational level but inversely related with their age.

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Download the full paper

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Government of Kenya. 2010. Agricultural Sector Development Strategy (2010 – 2020). Retrieved 20th October, 2016 from https://www.ascu.go.ke.

Jaetzold R, Schmidt H, Hornetz B, Shisanya C. 2006. Ministry of Agriculture Farm Management Handbook of Kenya VOL. II-Part C Subpart C1. Nairobi: Ministry of Agriculture.

Kebeney S, Msanya B, Semoka J, Ngetich W, Kipkoech A. 2015. Socioeconomic factors and soil fertility management practices affecting sorghum production in western Kenya: A case study of Busia county. American Journal of Experimental Agriculture 5(1), 1-11.

Kiptot E. 2008. Adoption dynamics of Tithonia diversifolia for soil fertility management in pilot villages of western Kenya. Experimental Agriculture 44, 73-484.

Kothari R. 2004. Research methodology, methods and techniques. New Delhi, New Age International (p) Ltd Publishers.

Marenya PP, Barrett CB. 2007. Household-level determinants of adoption of improved natural resources management practices among smallholder farmers in western Kenya. Food Policy 32, 515-536.

Matata P, Ajay O, Oduol P, Agumya A. 2010. Socio-economic factors influencing adoption of improved fallow practices among smallholder farmers in western Tanzania. African Journal of Agricultural Research 5(8), 818-823.

McCann JC. 2005. Maize and Grace. Africa’s Encounter with a New World Crop 1500–2000. Harvard University Press, Cambridge.

Nandwa SM. 2003. Perspectives on soil fertility in Africa. In: MP Gichuru, A Bationo, MA Bekunda, HC Goma, PL Mafongonya, DN Mugendi, HM Murwira, SM Nandwa, P Nyathi and M Swift (Eds). Soil fertility management in Africa: A regional perspective. Academic Science Publishers, Nairobi, Kenya.

Nkamleu GB. 2007. Modelling farmers’ decisions on integrated soil nutrient management in sub-Saharan Africa. A multinomial logit analysis in Cameroon. In: Bationo (Ed). Advances in intergrated soil fertility management in sub-Saharan Africa: Challenges and opportunities. Springer Publishers Netherlands 891-903.

Noordzij M, Tripepi G, Dekker F, Zoccali C, Tanck M, Jager K. 2010. Sample size calculations: basic principles and common pitfalls. Nephrol Dial Transplant 25, 1388-1393.

Obura PA, Okalebo JR, Woomer PL. 1999. The effect of PREP-PAC. Components on maize soybeans growth, yield uptake in the acid soil of western Kenya, PREP annual report.

Odendo M, Obare G, Salasya B. 2010. Determinants of the speed of adoption of soil fertility enhancing technologies in western Kenya. Contributed Paper presented at the Joint 3rd African Association of Agricultural Economists (AAAE) and 48th Agricultural Economists Association of South Africa (AEASA) Conference, Cape Town, South Africa, September 19-23, 2010.

Odendo M, Ojiem J, Bationo A, Mudeheri M. 2006. On-farm evaluation and scaling-up of soil fertility management technologies in western Kenya. Nutrient Cycling in Agroecosystems 76, 369-381.

Okalebo JR, Othieno CO, Woomer PL, Karanja NK, Semoka JRM, Bekunda MA, Mugendi DN, Muasya RM, Bationo A, Mukwana EJ. 2006. Available technologies to replenish soil fertility in East Africa. Nutrient Cycling in Agroecosystems 76, 153-170.

Ramisch JJ, Misiko MT, Ekise IE, Mukalama JB. 2006. Strengthening ‘Folk Ecology’: community based learning for integrated soil fertility management, western Kenya. International Journal of Agricultural Sustainability 4(2), 154-168.

Sanchez PA, Denning GL, Nziguheba G. 2009. The African green revolution moves forward. Food Security 1, 37-44.

Sanginga N, Woomer PL (Eds.). 2009. Integrated soil fertility management in Africa: Principles, practices and developmental process. Tropical Soil Biology and Fertility Institute of the International Centre for Tropical agriculture. Nairobi p. 263

Sileshi G, Akinnifesi FK, Debusho LK, Beedy T, Ajayi OC, Mongomba S. 2010. Variation in maize yield gaps with plant nutrient inputs, soil type and climate across sub-Saharan Africa. Field Crops Research 116, pp 1-13.

Smaling E, Nandwa S, Janssen B. 1997. Soil fertility in Africa is at stake. In Buresh, R., Sanchez, P. and Calhoum, F. (eds), Replenishing soil fertility in Africa. SSSA Special Publication, 51, Madison, USA.

Vanlauwe B, Bationo A, Chianu J, Giller KE, Merckx R, Mokwunye U, Ohiokpehai O, Pypers P, Tabo R, Shepherd KD, Smaling EMA, Woomer PL Sanginga N. 2010. Integrated soil fertility management: Operational definition and consequences for implementation and dissemination. Outlook on Agriculture 39(1), 17-24.

                                                          PO Mongare, JR Okalebo, CO Othieno, JO Ochuodho, AK Kipkoech, AO Nekesa.

Findings from a survey in Western Kenya to determine the soil fertility replenishment technologies adoption rates.

Int. J. Agron. Agri. Res. 15(6), 1-9, December 2019.

https://innspub.net/ijaar/findings-survey-western-kenya-determine-soil-fertility-replenishment-technologies-adoption-rates/

                                                          Copyright © 2019

By Authors and International Network for

Natural Sciences (INNSPUB)

https://innspub.net                

innspub.net

[bdscuatui]

Giao dịch Bất động sản Quận Erie - Tin tức Buffalo Sau đây là các giao dịch bất động sản trên 5.000 đô la như được liệt kê trong hồ sơ của văn phòng thư ký Quận Erie trong tuần kết thúc vào ngày 14 tháng 2. AKRON • 22 Lưỡi liềm, Douglas S. Matusek đến Heather Taylor, $ 181.000. ALDEN • 3613 Đường Crittenden, Ngân hàng Wells Fargo NA cho Jeremy David Kidder, $ 41,250. AMHERST • 595 Commerce Drive, 595 Commerce Drive Associates đến 595 Commerce LLC, $ 1,250,000. • 5385 Main St., 5385 Main St. LLC đến 5385 Main St. Village LLC, $ 1,050,000. • 100 Galileo Drive, Mary Ann Fenton cho Anna Brooks; David Brooks, $ 910.500. • 77 Tòa án Brownstone, Frank M. Davis đến Theresa A. Richard, $ 745.000. • 60 Hobnail Drive, Yin Chu Chen; Michael C. Yu đến Seevaratnam Jeevakaran; Tharshini Jeevakaran, $ 435.000. • 14 Buxton, Lapideas LLC đến Auston A. Mavrak; Shana L. Mavrak, 420.000 USD. • 41 Old Tower Lane, Marrano / marc Equity Corporation đến Kerry T. Lorich; Michael P. Lorich, $ 403,254. • 65 Huxley Drive, David C. Dean; Jean B. Dean đến Anne M. Cumbo; Thomas J. Cumbo, 350.000 đô la. • 195 đường Amherstdale, Robert J. Olivieri đến Andrew J. Farrell; Hayley A. Farrell, 260.000 đô la. • 281 Kaymar Drive, Linda L. Lloyd; Linda L. Spoth đến Latifa LLC, 240.000 đô la. • 11 Fawnwood Drive, Barbara Altman cho Henry Hoàng; Ellen Huynh, $ 215.000. • Đường 76 North Union, Juan D. Francis; Wendy Francis đến Tập đoàn tài chính Cartus, 205.000 đô la. • 76 North Union Road, Cartus Financial Corporation đến Elizabeth H. Schaab; Richard A. Schaab, 205.000 đô la. • 58 Nancy Lane, Blanchco Holdings LLC đến Hillary J. Blanchard, 200.000 đô la. • 320 Bucyrus Drive, Justin Holmer; Kristen Holmer đến Cynthia C. Beverly, 187.000 đô la. • 190 North Forest Road, Alice D. Dean to Audrey E. Drake, 180.000 đô la. • 2810 Dodge Road, Bertha Regnet; Bertha M. Regnet; Bertha Regnet Living Trust 072011 Tr cho Donald W. Heim, 165.000 đô la. • 380 Callodine Ave., Linda M. Panteli; Pantelis K. Panteli đến Allison C. Panteli; Kypros D. Panteli, $ 159.000. • 10030 Đường quá cảnh, Deborah L. Floss; Joseph M. Floss cho Laura C. Floss-Wilson; Wesley R. Wilson, 148.000 đô la. • 249 Đại lộ Thác Niagara, Brenda P. Kij đến Kuldeep K. Mann, 135.000 đô la. • Đại lộ 286 Rosedale, Stephanie Bueme; Stephanie Randall đến Brenden P. Stoll, 128.000 đô la. • 59 Elm Road, Neal T. Turvey cho Richard Jeramie Steele, 112.000 đô la. • 289 South Union Road, Random Properties Acquirition Corp III đến Minooli LLC, 109.250 đô la. Rừng LLC đến Ryan ngôi nhà của New York, 88.000 đô la. • 300 Homecrest Drive, Emily Harbison; Michael C. Scinta đến Lsf10 Master Trion Trust Tr; Ngân hàng Hoa Kỳ NA Tr, $ 82.322. • 1755 Charlesgate Circle, Marianne Ney đến Amit Malik, $ 78.000. • 3936 Ridge Lea Rd Đơn vị B, Ngân hàng Niagara đầu tiên NA Suc; Keybank NA đến Sharon C. Dwyer; Stephen P. Furlani, 74.000 USD. AURORA / EAST AURORA • 298 Ellicott Road, 3500 Genesee Associates LLC đến Rnh 298 LLC, 999.990 đô la. • 25 Aurora Mills Drive, Marrano / marc Equity Corporation đến Catherine M. Roach, 424.826 đô la. Marygrace Piskorowski cho Benjamin S. Collier; Nicole A. Kubiczki, $ 268.000. • 61 Bowen Road, Andrea G. Hoffower; Gregory D. Hoffower cho David P. Jezewski, 240.000 đô la. • 256 Oakwood Ave., Waterfall Reverse Reo Trust LLC đến Paul R. Marzello Jr., 175.000 đô la. • 2-4 Woodbrook Drive, Matthew R. Monroe cho Brian L. Deperro; Sharon A. Deperro, 129.900 đô la. • Đất trống Blakeley Road, Barbara Greeley; Judith Smolinski; Therese Lee Webber cho Diana L. Wolf, 125.000 đô la. BLASDELL • 14 Arthur Ave., Buffalo Group LLC đến Holt Makeda T N, $ 154,900. • 11 Marlowe Ave., John K. Rooney; Moira K. Rooney cho Jennifer L. Tessey, 110.000 đô la. • 3831 South Park Ave., 3395 Orchard Park Road Inc đến Dominic L. 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Dirado, 60.000 đô la. • 306 Weston, Cơ quan quản lý cống Buffalo; Thành phố Buffalo đến Tahsin Tahmid, 60.000 đô la. • 46 Glor, Kskc Properties LLC đến Nairn LLC, 57.000 đô la. • 17 Oneida, New Buffalo Homes LLC đến Lc Strategic Holdings LLC, 57.000 đô la. • 11 Calumet, Rose E. Guerin cho Ohma Lin, 55.000 đô la. • 234 Dewey Ave., Rahim Dunston; Rahim Muhammad đến Ksa Assets Inc, 50.000 đô la. • 253 Chandler St., Patricia M. Virgil đến Kenneth Fawcett, 50.000 đô la. • 69 Ashton, Timothy James Elling đến Timothy A. Elling, 50.000 đô la. • 341 Shirley Ave., Đầu tư bất động sản Solid Oak LLC đến R & r Holdings của WNY LLC, 50.000 đô la. • 36 Mapleridge Ave., Carmen L. Harris; Robert J. Harris đến James H. Whitaker, 47.000 đô la. • 145 Briscoe Ave., Paulette Boswell; Tyrone F. Harris đến Lsf10 Master Trion Trust Tr; Ngân hàng Hoa Kỳ NA Tr, 46.233 đô la. • 224 Central Ave., Edward Sardina đến John Mason, 45.000 đô la. • 20 Celtic, Người bạn của Buffalo Inc đến Tofa Business Group Inc, 45.000 đô la. • 450 Wyoming, Ủy thác đầu tư Mkw 401k (001) Tr đến Tập đoàn kinh doanh Tofa, 45.000 đô la. • 101 Weimar, Kenneth B Stroud Ira Agt; Horizon Trust Company Cust to M & a Property Solutions LLC, 41.000 đô la. • 62 Hawley, Saree Properties LLC đến Sany Chavan, 40.000 đô la. • 742 Glenwood, Thành phố Buffalo đến Othello Carr, 40.000 đô la. • 406 Shirley, Thành phố Buffalo cho Hồi giáo Sharitable, 39.000 đô la. . • 96 Dorris Ave., Steven Levine Ira Ben; Công ty Trustco Trust Cust to Peninsula Wholesale Holdings Corp, 35.000 đô la. • 191 Baitz Ave., Cator Properties LLC đến Jacqueline Crouch, 35.000 đô la. • 2700 Bailey Ave., Presbypet of Western New York đến Macalpine Community Church of Buffalo New York, 34.000 đô la. 221 Merrimac, Cathleen A. Mcguire; Niềm tin P. Mcguire với Brian Mcguire, 31.000 đô la. • 2414 Bailey, Thành phố Buffalo cho Muhammad Arif, 30.000 đô la. • 525 Woodlawn Ave., Jacqueline D. Fleming đến All-Green Realty Inc, 30.000 đô la. Alice T. Wanat đến Lubu Buffalo Inc, 25.000 đô la. • 61 Pers Breath Ave., Abdul J. Khan đến Ripa Jannat Khan, 20.000 đô la. • 44 Lewis Road, Thomas Williams đến Andrew Ford, 17.500 đô la. • 119 Purdy St., David Rodolph; Elizabeth Rodolph đến Mohammed Yasin, 15.000 đô la. • 864 Woodlawn Ave., Llewellyn Daniel; Llewellyn Daniels đến Ssp bất động sản Buf Inc, 12.600 đô la. • 236 Shirley Ave., Christian & matthew Properties Inc đến Erik Esau, 11.000 đô la. Taibbi Jr., $ 6.000. CHEEKTOWAGA • 50-950 Thruway Plaza Drive, Carrols LLC đến Scf Rc Funding IV LLC, $ 3,015,625. • 1181 Đường thua lỗ, Robert J. Laskowski cho Adam R. Mullen; Jessica M. Schmitt, 199.500 đô la. • 925 Maryvale Drive, Gary James Mcelroy đến Anthony Muffoletto; Kim Muffoletto, 180.000 đô la. • 1159 Đường Pháp, John W. suchy đến Md Manjurur Rahman, 170.500 đô la. • 25 đường Giorgmer, Daryl T. Lopp; Thomas Lopp; Tom D. Lopp cho Michael D. Lopp, $ 170.000. • 43 Angela Lane, Raymond E. Clancy; Robert M. Clancy cho Daniel A. Nyberg; Karen M. Nyberg, $ 167.500. • 62 Colette Ave., 62 Colette Ave LLC đến Cassandra I. Pinkowski; Brittany L. Radel, $ 167.000. • 74 Armond Lane, Susan Subjeck đến Alexandra M. Costello; Benjamin S. Senior, 164.000 đô la. • 1004 Cleveland Drive, Mary Anne Merritt tới Oscar I. Barretto; Evelyn Juarbe, $ 159,900. • 160 Brentwood Drive, Joshua P. Detlef; Rebecca K. Detlef đến Nathan Epolito; Jamie Reidy, 155.600 đô la. • Đường 173 Hillpine, Teresa E. Aumer; Sharon Marie Zajac đến Terrence Morrissey, 153.000 đô la. • 52 Đại lộ Mân côi, Alexandra Kaible; Alexander Scott đến Peggy Coutlakis, 150.000 đô la. • 88 Balbach Drive, Ryan Kuznik; Kayla Williams cho Emily Ellis; Salvatore A. Rine, $ 145.000. • Đại lộ 252 Oehman, Ahmed Jmaii đến Emma Hawke; Shawn Hawke, 138.000 USD. • Đại lộ 104 Oehman, Gerald F. Galey; Mary A. Galey cho Robert Koerntgen Ira Ben; Công ty ủy thác vốn cổ phần, $ 137.500. • 131 South Huxley Drive, Christina I. Fowler to Danielle M. Leung; Donald H. Leung Jr., 133.900 đô la. • 160 Cỏ ba lá, James T. Tycz cho Craig R. Secor, 128.300 đô la. • 20 Grant St., Nancy Lomas; Steven Frank Lomas đến Robert W. Koteras, 122.000 đô la. • 147 Wanda Ave., Richard A. Urbanski đến Sgtm Holdings LLC, 120.000 đô la. • 43 Đường Preston, Triple Z Enterprises LLC đến Kiesha Rivera, 115.000 đô la. • 120 Colden Court, Kathleen L Rosiek; James K. Stuber; Larry P. Stuber; Richard A. Stuber Jr. đến Lailuma Meherdil, 114.000 đô la. • 91 Colby St., Ruth V. Nguyen đến Patricia E. Simons, 110.000 đô la. • Địa điểm 116, Jeanna M. Cellino; Bensalem Khalid cho Christiana Tin tưởng Tr; Hilldale Tin tưởng Tr; Hội tiết kiệm quỹ Wilmington Fsb Tr dba, 93.755 đô la. • 37 Jackie Lane, Michael Cimasi; Kumro Gary W Est đến Demato Development LLC, $ 91.500. • 51 Westchester Drive, Russell A. Mantione đến Amanda M. Costanzo; Nicholas W. Martinelli, 88.000 đô la. • 20-22 Elkhurst Drive, Tracey Dillemuth; Donald Lorrens cho Pauline M. Panna, 83.000 đô la. • Tòa án 5 Janine, Michael Gawinski đến 160 Kokomo LLC, 80.000 đô la. • 35 Crane St., Michael J. Racine cho Keith Canazzi Ira Ben; Công ty ủy thác vốn cổ phần, 80.000 đô la. • 150 Roland St., Nicole K. Lojek; Nicole K. Volpe đến Ysms Property Holdings LLC, 70.000 đô la. • 14 Hedwig Ave., HUD đến Cong Van Huynh, 56.000 đô la. • 12-14 Sandstone, Arthur J. Yates Jr. đến Elgin LLC, 55.500 đô la. • 50 Grand Boulevard, Stephen W. Smith đến Anthony S. Castronova, 45.000 đô la. • 1047 Đường Beach, Cynthia A. Bolis; Đánh dấu S. Bolis cho Rockstar Homes LLC, 45.000 đô la. • 120 Colden Court, Kenneth R. Stuber đến Lailuma Meherdil, 28.500 đô la. • 8 Delray Drive, Robert P. Johnson; Lance G. Lavigne; Sherry L. Lavigne đến Duane Barwell; Chủ nhà WNY, $ 24,700. CÂU HỎI • 4135 Đường vận chuyển, Tru 2005 Re I LLC đến Mdc Coast 17 LLC, $ 8,790,505. • 9433 Hunting Valley Rd S, Timothy Andruschat; Maureen A. Giokas; Michael Giokas đến Ngân hàng Năm sao, 700.000 đô la. • 6700 Westminster Drive, Gregory W. Henzler; Rosalyn Henzler to We Richt Mobility Mobility Inc, $ 586.500. • 6700 Westminster Drive, We Richt Workforce Mobility Inc cho Jose P. Cruz; Kristin M. Cruz, $ 586.500. • Tòa án Spruce 9313 Sitka, Joseph A. Fruscione; Krista Fruscione đến mùa thu Carini; Daniel Carini, 430.000 đô la. • 4675 ngõ Pepperwood, Dorothy A. Wzontek; Stephen M. Wzontek đến Joseph W. Yedinak; Molly C. Yedinak, $ 409.900. • 8916 ngõ gỗ, Kristin L. Marra đến Christopher Schiumo; Stephanie Schiumo, $ 264,900. • 4343 Cameron Drive, Albert G. Evans; Florentine Evans đến Kristin Marie Goetz, $ 189.500. • 4156 Oakwood Drive, Carol Ann King; Sandra L. Ponichtera cho Lisa M. Williams, $ 172.000. COLDEN • 9422 Đường Partridge, Patrick Emantic đến Ryno Cho thuê LLC, $ 250.000. MÀU SẮC • 2840 Gowanda Zoar Road, Brianna L. Cambio; Michael D. Logsdon cho Larry R. Miller Jr., $ 176.500. CONCORD • 24 North Edgewood Drive, Dorothy Holtz Cott đến Brianna L. Logsdon; Michael D. Logsdon, $ 172.500. • 67 Hardwood Drive, Van A. Schirmer to Leslie Hornung; Michael Korchynski, 153.500 đô la. • Đường giữa, Gokce Capital LLC đến John Rf Hedrich, 7.499 đô la. EDEN • 2867 Hillview Place, Suzanne R. Swanson đến Matthew J. Wiedemann; Danielle Wittek, 175.000 đô la. • 8670 Elizabeth Parkway, Brent A. Hardy đến Karie Colantino, 161.200 đô la. • 2781 George St., Daniel J. Schwabel đến Shannon M. Mahoney, 126.950 đô la. ELMA • 141 Đường Kinsley, John R. Sherk đến Deborah A. Franklin; Kenneth J. Franklin, $ 275,000. • 7881 Seneca St., Randall D. Wuest đến Brittany D. Rashbrook; James D. Rashbrook, 205.000 đô la. • Đường đất trống, Đường Eckam Douglas Charles Jr; Douglas Eckam Jr. đến 460 E Center LLC, $ 49,900. MỌI NGƯỜI • 1443 Darlington Drive, Louis Celia; Vicki L. Celia cho Sara J. Lelonek, 155.000 đô la. • 1383 Đường Burns, John T. Nowak Jr. đến Brandon J. Genek; Ryan F. Genek, $ 121,540. • 1376 Ổ đĩa Độc lập, Lynette Sue Koscielski; Michael Koscielski đến Jeanne Ohara; John Ohara, 80.000 đô la. • 9567 Oakland St., Colleen Fendt to Keith Hooper, 40.000 đô la. • 105 South Lane Road, American Homeowner Preservation Trust Series 2015a + Tr; Ngân hàng Hoa Kỳ ủy thác NA Tr cho Công ty Đông Bắc Bất động sản LLC, 17.000 đô la. ĐẢO GRAND • 149 Woodstream, Christy L. Frank; Michael W. Frank đến Alicia C. Tarasek; Joshua D. Tarasek, 300.000 đô la. • 2818 Đường Đông sông, Joseph W. Carosella đến David Michael Bruno, 125.000 đô la. • 1150 Lasalle Ave., Golda Theodore S Est; Philip D. Leone cho Keith Canazzi Ira Ben; Công ty ủy thác vốn cổ phần, $ 82.000. HAMBURG • 4490 Lake Ave., Floyd C. Huntz đến Marotta Property Management LLC, $ 550,000. • 4543 # 37 Camp Road, Villages of Mission Hills Patio Homes LLC đến Edward J. Luba; Lola Irene Luba, 362.700 đô la. • 4543 # 49 Đường Camp, Làng của Mission Hills Patio Homes LLC đến Josefina E. Offredo, $ 326.300. • 3330 Ngõ quê, Joel M. Bearfield; John M. Bearfield; Judith M. Bearfield đến Natalie Bucholtz; George Griesbaum, $ 323,000. • 4025 Đường kết nối, Renee L. Gennocro; John J. Roberts đến Alexandra R. Izzo, $ 319.500. • 2416 Hobblebush Lane, Marrano / marc Equity Corporation đến Kelsey D. Gawronski; Kyle J. Gawronski, $ 296,183. • 4701 Đường Parker, Mz3 Properties LLC đến Jenna M. Vella; Joseph A. Vella, $ 265.500. • 21 Sherburn Drive, Carol M. Maurer đến Kelsey Marie Garey; Peter Bruce Walbrandt, $ 235.500. • 6501 Đường Heltz, Christine Popovski; Nikola Popovski đến Jm trọ LLC, $ 220.000. • 1537 Sundance Trl, Michele M. Smith; Russell J. Smith đến Brittany A. Lelonek, 153.000 đô la. • 3054 Lyth Road, Faith C. Fischer to Joel Iannaccone, 135.999 đô la. • 6368 Center St., Theodore Kalembkiewicz đến Glen William Farrell, 120.000 đô la. Dillsworth; Gary Dillsworth; Barbara M. Tate; Barbara Mae Tate cho Erica Kennedy, 117.000 đô la. • 42 Martha Place, Ngân hàng thứ ba NA cho Cindy S. Helinger; James R. Helinger, 112.500 đô la. • 5128 Thurston Ave., Helen M. Mcmahon; Robert F. Mcmahon cho Ashley E. Churchman; Ryan Y. Churchman, 111.000 đô la. • 6572 Taylor Road, Bcat 2015-14btt Tr; Christiana tin tưởng Tr; Hội tiết kiệm quỹ Wilmington Fsb Tr dba đến Glen Smith; Nicole Smith, 95.999 đô la. • 5673 Mckinley Parkway, Kbj Holding Company Inc đến Kb Homes LLC, 90.000 đô la. • 5255 Orchard Ave., Annmarie Rooth Cellino; Richard H. Roehm đến Daniel Hanna, 88.600 đô la. • 22 Robert St., Charles R. Rader; Charles Raymond Rader đến Laurie A. Munley; Nathan T. Munley, 85.000 đô la. • 4217 Mundy St., Suzanne M. Diaz đến Daniel Virant; Krystal Virant, 75.000 đô la. • Đất trống 35 Tòa án Jordy, Country Meadows kết hợp với Ryan ngôi nhà của New York, 48.000 đô la. HÀ LAN • 56 Nước St., Anna Agt Scheider; Emily Agt Scheider; Scheider William L Cust; Rachel Agt Trắng; Vỏ trắng Robert R II; Sarah Agt White đến John Covey, $ 82.500. • 56 Water St., Anna Agt Scheider; Emily Agt Scheider; Scheider William L Cust; Rachel Agt Trắng; Vỏ trắng Robert R II; Sara Agt Trắng đến Margaret M. White; Richard L. White, 15.000 đô la. LACKAWANNA • 11 Vòng tròn Highview, Robert Fulton đến Dexter Nowak; Jacqueline Nowak, 146.300 đô la. • 69 Verel Ave., Christopher P. Stone; Christopher Paul Stone; Jennifer Stone đến Rusia Musangwa; Etando Omari, $ 119.000. • 161 Wilmuth Ave., Lisa M. Mulder đến Dale Amos, 80.000 đô la. • 1693 Electric Ave., Daniel Virant; Krystal Virant cho Paul R. Borchlewicz, 75.000 đô la. • 41 Maple St., Shirley M. Pauley đến John Evancho, 52.500 đô la. • 282 Center St., Douglas S. Coppola; Hilda G. Hill đến Lmb Capital Inc, $ 40.300. LANCASTER • Đường 1432 Town Line, Nhà xây dựng Cmk của Alden Inc đến Melissa Bollman; Wesley D. Bollman, $ 428.500. • Đường 76 Freeman, Elisabeth Laistner; Fritz K. Laistner cho Alec Venturin, 204.000 đô la. • 96 Harvey Drive, John J. Marks cho Jessica A. Munzel; John P. Munzel, $ 182,000. • 11 James Place, Jennifer A. Sennett đến Shannon V. Carr, $ 178.500. • 41 School St., Patricia A. Landis; Patricia Adelle Landis đến R2m2 LLC, 90.000 đô la. • 6218 Broadway St., Alice Damato đến S & g Properties LLC, 27.000 đô la. MARILLA • 13304 Williston Road, Steven Herod đến Matthew V. Vanhauwaert, $ 258.000. • 11197 Clinton St., Tammie Cochran; Dean S. Puleo cho Mtglq Nhà đầu tư Lp, $ 254,937. • 11635 East Ave., Kathy L. Skingley cho Jamie L. Thompson; Jonathan D. Thompson, 55.000 đô la. BẢN TIN MỚI • 7768 Đường Fletcher, James Dematteo; Darryl J. Schmid; Trudith L. Schmid gửi ủy thác cho vay thế chấp Stanwich F Tr; Hội tiết kiệm quỹ Wilmington Fsb Tr, $ 96,102. • 4326 South Newstead Road, C & f Brothers LLC đến Bryan P. Kern; Shannon M. Kern, 75.000 đô la. • Vùng đất trống Cedar St., Cord Jones đến Elizabeth A. Graney; Patrick M. Graney, 55.000 đô la. ORCHARD PARK • 5959 Big Tree Road, Quaker 20a Realty LLC đến Công viên Orchard 5959 Medical Properties LLC, 44.500.000 đô la. • Đất trống California Road, Gordon J Sheffer Tin tưởng không thể thu hồi 042815 Tr đến Orchard Park Equity Associates LLC, $ 530.000. Margaret Schoell; Đánh dấu Schoell cho Hailley A. Fenski; John P. Fenski, $ 380.000. • 96 Eddy Lane, Joyce M. Day đến Emily Kristen Garrison; Matthew James Webb, 240.000 đô la. • 54 Puritan Place, Jace Tyler Gangel đến Robert L. Buscaglia, 206.000 đô la. • 80 Vistula Ave., Alan B. Huegel Jr. đến John J. Roberts, 205.000 đô la. • 7957 Michael Road, Dawn M. Vogel; William T. Vogel cho Ashlie Taylor Chojecki; Debbie Wendel Chojecki; Richard Michael Chojecki, $ 153,900. MÙA XUÂN • 30 Rachel Lane, Niềm tin của William F Garlock Tr cho Catherine A. Ford, 152.500 đô la. THÀNH PHỐ TONAWANDA • 11 Vòng tròn Ridgedale, Đoàn Trang Đỗ; Nicholas Zachary Howard đến Vicki A. Keleman, 199.900 đô la. • 63 Fuller Ave., Jill M. Phúc lợi cho Nicolette L. Bezek, 160.000 đô la. • 94 Harriet St., Corbett Frank LG đến Tiana S. Hall, 150.500 đô la. • 260 Hinds St ., Conor J. Margraf cho Louis Rogers III, $ 137,000. • 108 State St., Cutting Edge Holding LLC; Cắt Edge Holdings LLC cho Bryan E. Darrow, $ 115.500. TONAWANDA • 474 Đại lộ Thác Niagara, Syed Eajazul Haq đến Jujhar Developments LLC, $ 245.000. • 597 Englewood Ave., Lori Hassinger; Paul E. Hassinger đến Lsf9 Master Trion Trust Tr; Ngân hàng Hoa Kỳ NA Tr, 205.829 đô la. • 147 Louvaine Drive, Colleen A. Poeller cho Faye L. Greco; Peter J. Greco, 179.900 đô la. • 99 Springfield Ave., Sara D. Danheiser đến Shelby J. Allen, 175.000 đô la. • 133 Bathurst Drive, Daniel A. Nyberg tới Sarah Sankey, 170.000 đô la. • 542 Glenalby Road, Vicki A. Keleman Kristopher T. Kavanagh, 165.000 đô la. • 160 Tulane, Scott F. Brazee; Chelsea Wilczek đến Chinequia Williams, 155.000 đô la. • 254 Moore Ave., Judith A. Dagustine; Patrick R. Dagustine cho Anna Marie Turski; Ralph Joseph Wilson, $ 146,400. • 235 Joseph Drive, Dorothy K. Folck; Dorothy Kinda Folck đến John Edward Pfalzer, 140.000 đô la. • 17 Edgewood Ave., Denise M. Rackl đến Laura M. Galatioto, 127.000 đô la. • Đường 124 Treadwell, Diane kích thích đến Nikki Maria Parlato, 125.000 đô la. đến Jacob Wisor, $ 118,450. • 177 Mcconkey, Phyllis J. Tuhovak; Stephen M. Tuhovak đến Matthew W. Langenfeld, $ 118.000. • 63 Hawthorne Ave., Elmer S. Gee Jr.; Linda R. Gee; James A. Partacz đến Limaz LLC, 106.000 đô la. • 40 Ermann Drive, Rita Sliwinski Tin tưởng không thể hủy ngang Tr đến Cassandra L. Kerr, 97.938 đô la. • 130 Euclid Ave., Mohammed H. Said; Muhammed H. Đã nói với Queen House Inc, 90.000 đô la. • 131 Ralston Ave., Anthony Joseph Lana; Michael C. Olson; Phyllis Olson cho Tập đoàn thế chấp cho vay mua nhà liên bang, 84.099 đô la. • 305 Homewood Ave., Daniel R. Bunch Sr. đến Robert Koerntgen Ira Ben; Công ty ủy thác vốn cổ phần, 70.000 đô la. • 2858 Đường Eggert, Robert C. Baron; Michele M. Gajewski; Michele Perfetti đến Ngân hàng Citizens NA, 68.300 đô la. • 270 Tremaine Ave., Terrance M. Williams đến Micah Golba, 60.650 đô la. TÂY SENECA • 20 Circle End Drive, Paul Frontera; Lynn Rizzo-George đến Emily I. Brill; Jason R. Brill, 225.000 đô la. • Đường 248 Wind Mill, David J. Drzymala đến Steven Gaiser; Lisa Wisniewski, 195.900 đô la. • 118 đường Icner, Clifford J. Alf Jr. đến Amy Lynn Sitarski, 179.900 đô la. • 83 Angelacrest Lane, Ronald T. Wilczak đến Chad B. Blanar; Jessica L. Blanar, $ 167.500. • 36 Sibley Drive, Mark Riley; Mark Joseph Riley cho Michael S. Crum, 165.000 đô la. • 418 Mill Road, Cooley 2014 Familty Trust 102314 Tr to Aaron W. Polanski, 154.000 đô la. • 49 Fremont Ave., Derek P. Termer; Sarah K. Termer cho Tyler Stevens; Elisa N. Vazquez, 140.000 đô la. • 3880 Seneca St., James C. Horder; John Mccracken; Richard B. Scott đến Kyle Lelito, 120.000 đô la. • Đường dự trữ đất trống, Quan hệ đối tác gia đình Peter Liberatore; Peter Liberatore Sr Family Limited hợp tác với Hanley Phát triển WNY Inc, 114.000 đô la. 1080 Dự trữ Rd Đơn vị 3, Ae Buffalo Properties LLC đến William Severyn Sr., 47.000 đô la. • 4-5 Ruskin, Stefan Kablak đến Daniel T. Gawel, 40.000 đô la. [ad_2] Nguồn

[forestcrack83-blog]

Restless Legs Syndrome dramatically reduced by vitamin D, etc

RLS has been treated by Vitamin D, Magnesium and Iron

VitaminDWiki Summary

Unknown amount of vitamin D was given to 12 adults with Restless Legs Syndrome RLS scores decreased dramatically from 26 down to 10 RLS Scoring is attached at the bottom on this page: 40 = worst to 0 = none Vitamin D levels went from 9 ng/mL to 25 ng/mL (trial lasted until each patient got > 20 ng: 3-8 months) Some received vitamin D orally, others by injection. Dosing was 8,000 IU liquid vitamin D/week OR 200,000 IU injection/ month Publisher wants $45 for the study

See also on VitaminDWiki

People with RLS often benefit from Magnesium and/or Iron (see bottom of this page) VitaminDWiki expects RLS might be eliminated with if higher vitamin D levels were achieved in combination with Magnesium/Iron See also Vitamin D Council Cartoon from the web

RLS 3 X more likely if < 20 ng/mL of Vitamin D (8X more if was also a black teacher) – March 2018

The Association Between Vitamin D Level and Restless Legs Syndrome: A Population-Based Case-Control Study. J Clin Sleep Med. 2018 Mar 30. pii: jc-17-00496. [Epub ahead of print] Wali S, Alsafadi S, Abaalkhail B, Ramadan I, Abulhamail B, Kousa M, Alshamrani R, Faruqui H, Faruqui A, Alama M, Hamed M.

STUDY OBJECTIVES: The pathophysiology of restless legs syndrome (RLS) may be related to abnormalities in central dopamine pathways. Vitamin D may play a role in the pathophysiology of RLS by modulating the dopaminergic system. The aim of our study is to examine the possible link between RLS and vitamin D deficiency.

METHODS: The total number of subjects enrolled was 201, including 78 patients with RLS based on the International RLS Study Group (IRLSSG) diagnostic criteria and 123 controls. Serum 25-hydroxy vitamin D levels were measured in both groups. RLS severity was assessed in all cases using the IRLSSG symptom severity rating scale.

RESULTS: Fifty-nine patients with RLS (75.6%) and 52 controls (42.3%) had a diagnosis of vitamin D deficiency, P< .001. The odds ratio (OR) of the development of RLS was 4.24 for those with a vitamin D level < 50 nmol/L compared to those with a vitamin D level ≥ 50 nmol/L (P< .001, 95% confidence interval CI 2.3-7.9). After adjusting for all other significant factors in the multivariate logistic model, vitamin D was significantly associated with RLS (OR 3.1, P< .002, 95% CI 1.51-6.38). Moreover, a dark or black skin color (OR 3.4, P< .001, 95% CI 1.5-6.3) and working as a teacher (OR 8.8, P< .001, 95% CI 3.4-23.5) were also independently significantly associated with RLS.

CONCLUSIONS: Our study identified an association between vitamin D deficiency and RLS. Consequently, vitamin D deficiency should be considered in the management of RLS. However, further studies are needed to evaluate the causality relationship between vitamin D level and RLS.

PMID: 29609719

RLS score dropped from 26 to 10 after Vitamin D levels were raised to just 25 nanograms - 2014

The effect of vitamin D supplements on the severity of restless legs syndrome Sleep Breath. 2014 Aug 23. [Epub ahead of print] https://doi.org/10.1007/s11325-014-1049-y Wali S1, Shukr A, Boudal A, Alsaiari A, Krayem A. 1Sleep Medicine and Research Center, King Abdulaziz University, Jeddah, Saudi Arabia, sowali at kau.edu.sa.

PURPOSE: Clinical observation hinted improved symptoms of restless legs syndrome (RLS) after vitamin D supplements. Hence, the aim of this study is to evaluate the effect of vitamin D supplementation on the severity of RLS symptoms. METHODS: Twelve adult subjects diagnosed with primary RLS and vitamin D deficiency were recruited. Patients with secondary RLS were excluded from this study. The complete cell count; serum levels of ferritin, iron, glycated hemoglobin, and vitamin D3 (25 (OH) vitamin D); and renal and bone profiles of the patients were assayed. Patients with vitamin D deficiency (<50 nmol/l) were treated with vitamin D3 supplements (high oral dose or intramuscular injection). The severity scores of RLS were reassessed after the vitamin D3 level was corrected to >50 nmol/l and compared with those before the administration of the supplements. RESULTS: The median pretreatment vitamin D level was 21.7 nmol/l (13.45-57.4), which improved to 61.8 nmol/l (42.58-95.9) (P = 0.002) with the treatment. The median RLS severity score improved significantly from 26 (15-35) at baseline to 10 (0-27) after correction of the vitamin D levels (P = 0.002). CONCLUSION: This study indicates that vitamin D supplementation improves the severity of RLS symptoms and advocates that vitamin D deficiency is conceivably associated with RLS.

PMID: 25148866 Publisher wants $40 for the PDF Sci-Hub.tw has a free copy - March 2018

References

Ohayon MM, O'Hara R, Vitiello MV (2012) Epidemiology of restless legs syndrome: a synthesis of the literature. Sleep Med Rev 16:283–295 CrossRef

Phillips B, Young T, Finn L, Asher K, Hening WA, Purvis C (2000) Epidemiology of restless legs symptoms in adults. Arch Intern Med 160:2137–2141 CrossRef

Berger K, Luedemann J, Trenkwalder C, John U, Kessler C (2004) Sex and the risk of restless legs syndrome in the general population. Arch Intern Med 164:196 CrossRef

Ibia M, Sawadab H, Nakanishia M, Kumea T, Katsukia H, Kanekoc S, Shimohamab S, Akaikea A (2001) Protective effects of 1,25-(OH)2D3 against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture. Neuropharmacology 40:761–771 CrossRef

Prakash S, Bhanvadia RJ, Shah ND (2010) Restless legs syndrome with carbamazepine-induced osteomalacia: causal or casual association. Gen Hosp Psychiatry 32(2):228

Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J (2003) Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med 4(2):101–119 CrossRef

Walters AS, LeBrocq C, Dhar A, Hening W, Rosen R, Allen RP, Trenkwalder C, International Restless Legs Syndrome Study Group (2003) Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med 4:121–132 CrossRef

Abetz L, Arbuckle R, Allen RP, Garcia-Borreguero D, Hening W, Walters AS, Mavraki E, Kirsch JM (2006) The reliability, validity and responsiveness of the International Restless Legs Syndrome Study Group rating scale and subscales in a clinical-trial setting. Sleep Med 7(4):340–349 CrossRef

Alsuwadia AO, Farag YM, Al Sayyari AA, Mousa DH, Alhejaili FF, Al-Harbi AS, Housawi AA, Mittal BV, Singh AK (2013) Prevalence of vitamin D deficiency in Saudi adults. Saudi Med J 34(8):814–818

BaHammam A, Al-shahrani K, Al-zahrani S, Al-shammari A, Al-amri N, Sharif M (2011) The prevalence of restless legs syndrome in adult Saudis attending primary health care. Gen Hosp Psychiatry 33(2):102–106 CrossRef

Balaban H, Yıldız ÖK, Çil G, Şentürk İA, Erselcan T, Bolayır E, Topaktaş S (2012) Serum 25- hydroxyvitamin D levels in restless legs syndrome patients. Sleep Med 13(7):953–957 CrossRef

Allen RP, Earley CJ (2007) The role of iron in restless legs syndrome. MovDisord 22(18):440–448

Zucconi M, Manconi M (2008) Sleep and quality of life in restless legs syndrome. In: Verster JC, Pandi-Perumal SR, Streiner D (eds) Sleep and quality of life in clinical medicine. Humana Press, Totowa, NJ

Manconi M, Ferri R, Zucconi M, Clemens S, Giarolli L, Bottasini V, Ferini-Strambi L (2011) Preferential D2 or preferential D3 dopamine agonists in restless legs syndrome. Neurology 77(2):110–117 CrossRef

Walters AS, Rye DB (2009) Review of the relationship of restless legs syndrome and periodic limb movements in sleep to hypertension, heart disease, and stroke. Sleep 32(5):589–597

Meguro S, Tomita M, Katsuki T, Kato K, Oh H, Ainai A, Ito R, Takeda S, Kawai T, Atsumi Y, Itoh H, Hasegawa H (2011) Plasma 25- hydroxyvitamin D is independently associated with hemoglobin concentration in male subjects with type 2 diabetes mellitus. Int J Endocrinol 362981:5. doi:10.1155/2011

Abou-Raya S, Helmii M, Abou-Raya A (2009) Bone and mineral metabolism in older adults with Parkinson’s disease. Age Ageing 38(6):675–680 CrossRef

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Garcia-Borreguero D, Kohnen R, Boothby L, Tzonova D, Larrosa O, Dunkl E (2013) Validation of the multiple suggested immobilization test: a test for the assessment of severity of restless legs syndrome (Willis-Ekbom disease). Sleep 36(7):1101–1109

Restless Legs Syndrome 5X more likely if vitamin D deficient - May 2014

Possible association between vitamin D deficiency and restless legs syndrome Neuropsychiatr Dis Treat. 2014 May 21;10:953-8. doi: 10.2147/NDT.S63599. eCollection 2014. Oran M1, Unsal C2, Albayrak Y2, Tulubas F3, Oguz K4, Avci O1, Turgut N4, Alp R4, Gurel A3.

BACKGROUND AND AIM: Restless legs syndrome (RLS) is a distressing sleep disorder that occurs worldwide. Although there have been recent developments in understanding the pathophysiology of RLS, the exact mechanism of the disease has not been well elucidated. An increased prevalence of neurologic and psychiatric diseases involving dopaminergic dysfunction in vitamin D-deficient patients led us to hypothesize that vitamin D deficiency might result in dopaminergic dysfunction and consequently, the development of RLS (in which dopaminergic dysfunction plays a pivotal role). Thus, the aim of this study was to evaluate the relationship between vitamin D deficiency and RLS.

METHODS: One hundred and fifty-five consecutive patients, 18-65 years of age, who were admitted to the Department of Internal Medicine with musculoskeletal symptoms and who subsequently underwent neurological and electromyography (EMG) examination by the same senior neurologist, were included in this study. The patients were divided into two groups according to serum 25-hydroxyvitamin D (25(OH)D) (a vitamin D metabolite used as a measure of vitamin D status) level: 36 patients with serum 25(OH)D levels ≥20 ng/mL comprised the normal vitamin D group, and 119 patients with serum 25(OH)D levels <20 ng/mL comprised the vitamin D deficiency group. The two groups were compared for the presence of RLS and associated factors.

RESULTS: The two groups were similar in terms of mean age, sex, mean body mass index (BMI), and serum levels of calcium, phosphate, alkaline phosphatase (ALP), and ferritin. The presence of RLS was significantly higher in the vitamin D deficiency group (χ (2)=12.87, P<0.001). Regression analysis showed vitamin D deficiency and serum 25(OH)D level to be significantly associated with the presence of RLS (odds ratio [OR] 5.085, P<0.001 and OR 1.047, P=0.006, respectively).

CONCLUSION: The present study demonstrated a possible association between vitamin D deficiency and RLS. Given the dopaminergic effects of vitamin D, 25(OH)D depletion may lead to dopaminergic dysfunction and may have a place in the etiology of RLS. Prospective vitamin D treatment studies are needed to confirm this relationship and to evaluate the efficacy of vitamin D as a treatment for RLS patients.

PMID: 24899811 &nbspDownload the PDF from VitaminDWiki

See also RLS WikiPedia Aug 2014 (nothing about vitamin D)

Restless legs syndrome (RLS) also known as Willis-Ekbom disease (WED)[1] or Wittmaack-Ekbom syndrome, is a neurological disorder characterized by an irresistible urge to move one's body to stop uncomfortable or odd sensations.[2] It most commonly affects the legs, but can affect the arms, torso, head, and even phantom limbs.[3] Moving the affected body part modulates the sensations, providing temporary relief.

RLS sensations range from pain or an aching in the muscles, to "an itch you can't scratch", an unpleasant "tickle that won't stop", or even a "crawling" feeling. The sensations typically begin or intensify during quiet wakefulness, such as when relaxing, reading, studying, or trying to sleep.[4] Additionally, most individuals with RLS suffer from periodic limb movement disorder (limbs jerking during sleep), which is an objective physiologic marker of the disorder and is associated with sleep disruption.[5] It can be caused by low iron levels.[6]

RLS affects an estimated 2.5 to 15% of the American population .[6][60] A minority (around 2.7% of the population) experience daily or severe symptoms.

Magnesium reduced RLS - 1998

Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. Sleep. 1998 Aug 1;21(5):501-5. Hornyak M1, Voderholzer U, Hohagen F, Berger M, Riemann D.

Periodic limb movements during sleep (PLMS), with or without symptoms of a restless legs syndrome (RLS), may cause sleep disturbances. The pharmacologic treatments of choice are dopaminergic drugs. Their use, however, may be limited due to tolerance development or rebound phenomena. Anecdotal observations have shown that oral magnesium therapy may ameliorate symptoms in patients with moderate RLS. We report on an open clinical and polysomnographic study in 10 patients (mean age 57 +/- 9 years; 6 men, 4 women) suffering from insomnia related to PLMS (n = 4) or mild-to-moderate RLS (n = 6). Magnesium was administered orally at a dose of 12.4 mmol in the evening over a period of 4-6 weeks. Following magnesium treatment, PLMS associated with arousals (PLMS-A) decreased significantly (17 +/- 7 vs 7 +/- 7 events per hour of total sleep time, p < 0.05). PLMS without arousal were also moderately reduced (PLMS per hour of total sleep time 33 +/- 16 vs 21 +/- 23, p = 0.07). Sleep efficiency improved from 75 +/- 12% to 85 +/- 8% (p < 0.01). In the group of patients estimating their sleep and/or symptoms of RLS as improved after therapy (n = 7), the effects of magnesium on PLMS and PLMS-A were even more pronounced. Our study indicates that magnesium treatment may be a useful alternative therapy in patients with mild or moderate RLS-or PLMS-related insomnia. Further investigations regarding the role of magnesium in the pathophysiology of RLS and placebo-controlled studies need to be performed.

PMID: 9703590

&nbspDownload the PDF from VitaminDWiki

See also web - RLS and Vitamin D

See also web - RLS and Magnesium

See also VitaminDWiki - Magnesium

Source: https://vitamindwiki.com/tiki-index.php?page=Restless+Legs+Syndrome+dramatically+reduced+by+vitamin+D%2C+etc

[lucayxng]

"Oh! You work at the conservatory? I did think that your face looked familiar, that must be why. My research in Marine is in conjunction with the conservatory so much of my time is spent there when I'm not in the field. What do you do?" Luca was excited to make the acquaintance of one of his co-workers. He had been trying to reach out to some of the other workers there, but since his research project was his own, he didn't work directly with any of them for the most part. "Where are you from originally?"

"At the conservatory. Part time." He took his hand back after shaking the others and continued, "Usually what I do toward the end of the year. What about you?" Blue eyes gave a quick glance toward the cliffs and nodded. "Yeah, this place has great views. Food's pretty good too. Not really. Made the permanent move back in December but I have spent time here as a child. So sometimes feels like I've been here for a long time."

[philrcool-blog]

Winners of [Happy Valentines Day : Home Theme vote]

Feb 07, 2018

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[itsmedicinesfakianakis]

Effect of Pathologic Tumor Response and Nodal Status on Survival in the Medical Research Council Adjuvant Gastric Infusional Chemotherapy Trial.

Related Articles

Effect of Pathologic Tumor Response and Nodal Status on Survival in the Medical Research Council Adjuvant Gastric Infusional Chemotherapy Trial.

J Clin Oncol. 2016 Aug 10;34(23):2721-7

Authors: Smyth EC, Fassan M, Cunningham D, Allum WH, Okines AF, Lampis A, Hahne JC, Rugge M, Peckitt C, Nankivell M, Langley R, Ghidini M, Braconi C, Wotherspoon A, Grabsch HI, Valeri N

Abstract PURPOSE: The Medical Research Council Adjuvant Gastric Infusional Chemotherapy (MAGIC) trial established perioperative epirubicin, cisplatin, and fluorouracil chemotherapy as a standard of care for patients with resectable esophagogastric cancer. However, identification of patients at risk for relapse remains challenging. We evaluated whether pathologic response and lymph node status after neoadjuvant chemotherapy are prognostic in patients treated in the MAGIC trial. MATERIALS AND METHODS: Pathologic regression was assessed in resection specimens by two independent pathologists using the Mandard tumor regression grading system (TRG). Differences in overall survival (OS) according to TRG were assessed using the Kaplan-Meier method and compared using the log-rank test. Univariate and multivariate analyses using the Cox proportional hazards method established the relationships among TRG, clinical-pathologic variables, and OS. RESULTS: Three hundred thirty resection specimens were analyzed. In chemotherapy-treated patients with a TRG of 1 or 2, median OS was not reached, whereas for patients with a TRG of 3, 4, or 5, median OS was 20.47 months. On univariate analysis, high TRG and lymph node metastases were negatively related to survival (Mandard TRG 3, 4, or 5: hazard ratio [HR], 1.94; 95% CI, 1.11 to 3.39; P = .0209; lymph node metastases: HR, 3.63; 95% CI, 1.88 to 7.0; P < .001). On multivariate analysis, only lymph node status was independently predictive of OS (HR, 3.36; 95% CI, 1.70 to 6.63; P < .001). CONCLUSION: Lymph node metastases and not pathologic response to chemotherapy was the only independent predictor of survival after chemotherapy plus resection in the MAGIC trial. Prospective evaluation of whether omitting postoperative chemotherapy and/or switching to a noncross-resistant regimen in patients with lymph node-positive disease whose tumor did not respond to preoperative epirubicin, cisplatin, and fluorouracil may be appropriate.

PMID: 27298411 [PubMed – indexed for MEDLINE]

from #Esophageal Cancer via xlomafota13 on Inoreader http://ift.tt/2v2flaz

from OtoRhinoLaryngology - Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2v0JQxV

[nyraxodeyer]

She could not help the way her features fell at what he had said — wolfsbane, mountain ash, were whoever took them smart? Her head nodded in both as confirmation to her own question and to acknowledge that JC had spoken. "Of course, of course. Precautions. I wish we could take some to prevent all of this." Present and not as he continued Nyra began to drift into thought. She took what was stated as facts because they were such, yet what was she to tell a family that was besides themselves with worry? It was not at JC that she had heaved a heavy sigh, though the wolf greatly deserved it but at the inevitable that seemed to crash into them at any moment. Hope felt fickle and like smoke it seemed to slip through desperately clutching fingertips. "I have not, but we could. It's been a challenge to sort the actual leads from the wild, speculative theories."

That she could agree to, "I keep going to that too, she had to have done it with intention." It was a mission to hold back an eye roll at his comments, still she managed to hold it back somehow, "Look JC, you can disregard it, that's fine, but we both know Meena is not the type of person to do things without thought, especially under duress. I'm not going to start anything with you nor did I. I'll admit M could mean anything, but she was taken from the Manor, it could be an insight into where she's being held." She had intentions to check the hospital and morgue given the issues with medical equipment, and perhaps scope out the shadier parts of town too, like the motel, all the M places just to rule them out. "Do you not think I have better things to do with my time after she's found?" She wanted to add on to say he better not imply that Meena might be dead, but that would flare up her irritation alongside his.

JC had not really been home. For days now, his hours had been spent in the fruitless search, both on two legs and on four. He had been cancelling private sessions at the ice rink, something that pained him. But maybe it would somehow do them all good to simply accept that this was the way things were now. There would never again be travel to competitions. There would never again be Olympic dreams. All they did was lurch from tragedy to tragedy in Lunar Cove. The wolf could not help but bristle as Nyra alighted beside him.

"Same old. Nothing new," he replied briefly, giving a shake of his head. "I would have figured as much. I wish I could say someone in the pack had seen him." Or her. "But no one has." He sniffed, crossing his arms and giving a shake of his head. While he was not Nyra's number-one fan at the moment, or any of the Council members', he was at least trying to remain civil. "Not if whoever has him has taken precautions, and I assume they have. Lots of things can mess with the pack bond. Wolfsbane. A strong spell." He knit his brow. "Mountain ash. If they were smart, they'd have trapped with mountain ash." Júlio César knit his brow at that. "The van...it belonged to a florist, right? A florist would be able to access plenty of things that would keep a werewolf manageable." His nostrils flared. "Have we looked into that?"

JC grunted. "Who knows? I keep thinking of her ring. Why would she have even taken it off? I don't know what it could mean. And don't start up again on the 'm' clue. For both our sakes. In case any of you still feel the need to tattle to potentially dead teacher on me." He grit his teeth.

[ofbloodandsnow]

A challenge. How fun. "I'm sure we could find some use for them - I'm quite versatile." He made his way to the werewolf. He had to admit, while semi-transformed werewolves weren't really his type (mutton chops are pretty much always a big no), but he made work. "What am I doing? Well, it's a party, right? I'm just here for a little fun." A hand to his chest, he gasped in fake shock. "Oh my, Grandmother, what big claws you have(!)"

As the panic seized the room, Júlio César wasted no time pulling out his claws and teeth. He needed to be transformed to most clearly hear the back-and-forth now pulsing through the pack's shared psychic link. In truth, then, the only factor keeping him from fully morphing into his lupine form was time; there was none right now, not in the frenzy. And so, he moved through the room briskly in his half-wolf state, ushering humans and wolves alike through one of the emergency exit doors.

Sniffing the air, however, JC caught the scent of blood, stiffening a little as fights were beginning to break out. It was in that moment, then, that he locked eyes with Sébastien. He had not seen the likes of this, the darkened gaze, the strange power pulsing through his neighbors. But he knew witch bullshit when he saw witch bullshit. The wolf gave a shake of his head. "Oh no. You're gonna regret it if you come over here, guy. More teeth then you'll know what to do with. What're you doing?" He set out the signal to the other wolves still in the room, keeping them at a bay unless he needed them to jump to his own aid.

[lucayxng]

Luca reached out to shake JC's hand and returned the smile. There was something about the man that felt familiar to Luca, but he couldn't quite put his finger on it. "Ah, it is unfortunate when work comes between you and free food. I had a similar problem. Where do you work?" He considered JC's question briefly, looking out at the view from the top of the cliffs. "Well, the views are certainly nothing to scoff at. Have you lived here long?"

JC turned his head a smile quickly spending across his features at the other beside him. "Hey." Hearing the name he nodded and let out a soft chuckle. "It's nice to meet you Luca." With him traveling back and forth in the last week for his work he hadn't gotten a chance to get a run in around the cliffs. "I'm JC." His hand stretched out for the other to take. He had heard the name and something about a second marine biologist in town but wasn't a hundred percent sure if his companion was the one that was talked about. Though he only worked part time at the conservatory he always seemed to be in the loop with the latest developments. At the question he nodded. "Yeah. I did though had to cut out early. Work beckoned. But it was a lovely time. From that I gather you didn't get to go? How are you liking the town?"