#best transmission repair in Georgetown
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bsautosuppliess · 16 days ago
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Best Transmission for Yukon-GMC in Georgetown: Top Repair Services by BS Auto Supplies
When it comes to keeping your Yukon-GMC running smoothly, choosing the right transmission is essential. At BS Auto Supplies, we specialize in providing the best transmission for Yukon-GMC in Georgetown, ensuring your vehicle operates at peak performance. Whether you’re in need of a transmission replacement, repair, or maintenance, our expert team offers comprehensive services tailored to your needs.
We pride ourselves on delivering the best transmission repair in Georgetown. Our experienced technicians use the latest diagnostic tools and high-quality parts to fix any transmission issue, no matter the complexity. From slipping gears to unusual noises, we ensure that your Yukon-GMC’s transmission functions flawlessly. At BS Auto Supplies, we understand the importance of a reliable vehicle, and we’re committed to offering exceptional service that guarantees satisfaction. Visit us today for the best transmission solutions in Georgetown, and drive with confidence!
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eautocollision · 4 years ago
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eAutoCollision: Auto Body Shop 8027-8029 Foster Avenue Brooklyn NY 11236 (718) 517-9180 
https://www.eautocollision.com https://g.page/auto-body-shop-nyc/
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Working Hours: Mon-Sat 8:00am - 6:00pm;  Sun - closed Payment: cash, check, credit cards.
Trusted since 1999 to keep you and your family safe, eAutoCollision.com is the highest rated auto body repair shop in all five New York City boroughs. When it comes to high-performance vehicles, fleet services and preventative maintenance, there’s none better. The technicians at eAutoCollision are highly trained experts qualified to work on everything from heavy-duty trucks to electric cars. Their specialized auto body paint shop is incomparable, providing speedy quality paint jobs and touchups. From tune-ups to tire sales, you get it all at eAutoCollision. Call today to see what a difference it makes.
Where Can I Find a Trustworthy Car Mechanic in New York City? If you’re looking for an auto collision center in Brooklyn to handle the maintenance of your car, truck or SUV, your best option is eAutoCollision.com. In business since 1999, the Brooklyn vehicle repair shop employs recognized experts in auto repair. They’re also recognized as the best car paint shop in Manhattan, the Bronx, Queens, Staten Island or Brooklyn.
They take pride in their expert work on foreign and domestic vehicles. They can service your vehicle from start to finish, whether you need:
To get your vehicle up and running after a mechanical failure Auto body work after an accident Preventive maintenance to keep your vehicle in top condition What Does eAutoCollision’s Comprehensive Vehicle Repair Shop Offer? When you entrust the care of your vehicle to eAutoCollision, you’ll learn that they provide free estimates that they never exceed without your permission. Their technicians that have the tools, equipment and expertise needed to handle all types of repairs, large or small. They’re your dealer alternative, offering fast service at a better price than most dealerships. They specialize in computer programming and computerized scanning on most cars, including:
All personal and fleet vehicles Hybrids Electric vehicles Whether your car won’t start, is running rough or needs a New York State inspection, technicians certified by original equipment manufacturers (OEM) and the National Institute for Automotive Service Excellence (ASE) provide comprehensive auto repair services that include:
Diagnosing warning lights Transmission repair Muffler and exhaust repair Belts and hoses check
Auto electric repair Steering and suspension repair Ensuring your vehicle starts every time Electrical system repair Brake repair services Tire repair Tire replacement
Auto collision experts 
Nearby Areas 
Canarsie | East Flatbush | Georgetown | Flatlands | Brownsville 
11236 | 11203 | 11234 | 11212, 11233
Keywords: auto collision nyc, auto collision center nyc, auto collision center brooklyn, auto collision center, auto collision brooklyn, auto body shop repair, auto body shop nyc
Find us: tupalo.co
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austinmms · 3 years ago
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Fleet Service in Austin Texasmore information is at : http://mobilemechanicsaustin.com/fleet-service-near-me/Are you looking for Fleet Service In Austin Texas?  Austin Mobile Mechanic Service provides the Fleet Service in the whole town. Our professional team with their skilled techniques and complete knowledge provides the services which are needed by customers. Whether you are stuck in the mid of the road or you are in an emergency and you need Fleet Service then you can call us. Well, for the Fleet Service, we can provide you the best team for the services. For free estimates, contact us or book an appointment now. REQUEST FREE ESTIMATES Fleet Service in Austin Mobile Mechanic Service It’s no secret that maintaining a fleet can be a stressful, time-consuming obligation. Fortunately, the team at  Austin Mobile Mechanic Service is fully prepared to handle a job of this size.Our years of experience have allowed us to become familiar with every type of repair you could imagine, ranging from transmission issues to problems with the vehicle’s tires.In order to keep your fleet running smoothly, it’s highly recommended to regularly bring your vehicles in for preventive maintenance. FLEET SERVICE IN AUSTIN TEXASAUSTIN MOBILE MECHANIC SERVICEREQUEST MORE INFORMATION. CLICK HERE!OR CALL US!Service AreaAnderson Mill, TX Austin TX Barton Creek, TX Barton Hills, TX Bee Cave, TX Briarcliff, TX Brushy Creek, TX Cedar Creek, TX Cedar Park, TX Clarksville, TX Driftwood, TX Dripping Springs, TX Elgin, TX Georgetown, TX Granger, TX Hudson Bay, TX Hutto, TX Jollyville, TX Kyle, TX Lago Vista, TX Lakeway, TX Leander, TX Liberty Hill, TX Lost Creek, TX Manor, TX North Austin, TX NW Hills, TX Oak Hill, TX Pflugerville, TX Point Venture, TX Rollingwood, TX Round Rock, TX South Austin, TX Spicewood, TX Steiner Ranch, TX Taylor, TX The Hills, TX Travis Heights, TX West Lake Hills, TX Windemere, TX Wyldwood, TXZip Codes in Austin, Texas:76527 (Florence) 76530 (Granger) 76537 (Jarrell) 76573 (Schwertner) 76574 (Taylor) 76578 (Thrall) 78602 (Bastrop) 78610 (Buda) 78612 (Cedar Creek) 78613 (Cedar Park) 78615 (Coupland) 78616 (Dale) 78617 (Del Valle) 78619 (Driftwood) 78620 (Dripping Springs) 78621 (Elgin) 78622 (Fentress) 78626 (Georgetown) 78628 (Georgetown) 78633 (Georgetown) 78634 (Hutto) 78640 (Kyle) 78641 (Leander) 78642 (Liberty Hill) 78644 (Lockhart) 78645 (Lago Vista) 78648 (Luling) 78650 (Mc Dade) 78652 (Manchaca) 78653 (Manor) 78655 (Martindale) 78656 (Maxwell) 78659 (Paige) 78660 (Pflugerville) 78661 (Prairie Lea) 78662 (Red Rock) 78664 (Round Rock) 78665 (Round Rock) 78666 (San Marcos) 78669 (Spicewood) 78676 (Wimberley) 78681 (Round Rock) 78701 | 78702 | 78703 | 78704 | 78705 | 78712 | 78717 | 78719 | 78721 | 78722 | 78723 | 78724 | 78725 (Hornsby Bend) 78726 | 78727 | 78728 (Wells Branch) 78729 (Jollyville) 78730 | 78731 | 78732 | 78733 | 78734 (Lakeway) 78735 | 78736 | 78737 | 78738 (Bee Cave) 78739 | 78741 | 78742 | 78744 | 78745 | 78746 | 78747 | 78748 | 78749 | 78750 | 78751 | 78752 | 78753 | 78754 | 78756 | 78757 | 78758 | 78759 | 78953 (Rosanky) 78957 (Smithville)
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tvideos125 · 3 years ago
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Are you looking for Transmission Repair In Austin Texas? more information is at: https://mobiletruckrepairaustin.com/transmission-repair-near-me/ Mobile Truck Repair Austin provides  Transmission Repair  in the whole town. Our professional team with their skilled techniques and complete knowledge provides the services which are needed by customers. Whether you are stuck in the middle of the road or in emergency and need  Transmission Repair , you can call us. Well, for the Transmission Repair , we can provide you with the best team for the services. For free estimates, contact us or book an appointment now. REQUEST FREE ESTIMATES                         Transmission Repair in Mobile Truck Repair AustinIf you need transmission repair services, the team at  Mobile Truck Repair Austin is available around the clock to help. No job is too big or small for us to handle and we’re looking forward to meeting – and exceeding – your expectations for service. TRANSMISSION REPAIR IN AUSTIN TEXAS MOBILE TRUCK REPAIR AUSTIN REQUEST MORE INFORMATION. CLICK HERE! OR CALL US!SERVICE AREA OUR SERVICE AREA Anderson Mill: TX Austin TX Barton Creek, TX Barton Hills, TX Bee Cave, TX Briarcliff, TX Brushy Creek, TX Cedar Creek, TX Cedar Park, TX Clarksville, TX Driftwood, TX Dripping Springs, TX Elgin, TX Georgetown, TX Granger, TX Hudson Bay, TX Hutto, TX Jollyville, TX Kyle, TX Lago Vista, TX Lakeway, TX Leander, TX Liberty Hill, TX Lost Creek, TX Manor, TX North Austin, TX NW Hills, TX Oak Hill, TX Pflugerville, TX Point Venture, TX Rollingwood, TX Round Rock, TX South Austin, TX Spicewood, TX Steiner Ranch, TX Taylor, TX The Hills, TX Travis Heights, TX West Lake Hills, TX Windemere, TX Wyldwood, TX Zip Codes: 76527 (Florence) 76530 (Granger) 76537 (Jarrell) 76573 (Schwertner) 76574 (Taylor) 76578 (Thrall) 78602 (Bastrop) 78610 (Buda) 78612 (Cedar Creek) 78613 (Cedar Park) 78615 (Coupland) 78616 (Dale) 78617 (Del Valle) 78619 (Driftwood) 78620 (Dripping Springs) 78621 (Elgin) 78622 (Fentress) 78626 (Georgetown) 78628 (Georgetown) 78633 (Georgetown) 78634 (Hutto) 78640 (Kyle) 78641 (Leander) 78642 (Liberty Hill) 78644 (Lockhart) 78645 (Lago Vista) 78648 (Luling) 78650 (Mc Dade) 78652 (Manchaca) 78653 (Manor) 78655 (Martindale) 78656 (Maxwell) 78659 (Paige) 78660 (Pflugerville) 78661 (Prairie Lea) 78662 (Red Rock) 78664 (Round Rock) 78665 (Round Rock) 78666 (San Marcos) 78669 (Spicewood) 78676 (Wimberley) 78681 (Round Rock) 78701 | 78702 | 78703 | 78704 | 78705 | 78712 | 78717 | 78719 | 78721 | 78722 | 78723 | 78724 | 78725 (Hornsby Bend) 78726 | 78727 | 78728 (Wells Branch) 78729 (Jollyville) 78730 | 78731 | 78732 | 78733 | 78734 (Lakeway) 78735 | 78736 | 78737 | 78738 (Bee Cave) 78739 | 78741 | 78742 | 78744 | 78745 | 78746 | 78747 | 78748 | 78749 | 78750 | 78751 | 78752 | 78753 | 78754 | 78756 | 78757 | 78758 | 78759 | 78953 (Rosanky) 78957 (Smithville)
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a1mechanics · 3 years ago
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Are you looking for Transmission Repair In Austin?  
more information is at : http://a1mobilemechanicofaustin.com/transmission-repair-near-me/
A1 Mobile Mechanic of Austin provides the Transmission Repair in the whole town. Our professional team with their skilled techniques and complete knowledge provides the services which are needed by customers. Whether you are stuck in the mid of the road or you are in emergency and you need  Transmission Repair then you can call us. Well, for the Transmission Repair, we can provide you the best team for the services. For free estimates, contact us or book an appointment now.
REQUEST FREE ESTIMATES    
          Transmission Repair in  A1 Mobile Mechanic of Austin If you need transmission repair services, the team at  A1 Mobile Mechanic of Austin is available around the clock to help. No job is too big or small for us to handle and we’re looking forward to meeting – and exceeding – your expectations for service.
TRANSMISSION REPAIR IN AUSTIN
A1 MOBILE MECHANIC OF AUSTIN
REQUEST MORE INFORMATION. 
CLICK HERE!OR CALL US!
SERVICE AREA OUR SERVICE AREA Anderson Mill, TX Austin TX Barton Creek, TX Barton Hills, TX Bee Cave, TX Briarcliff, TX Brushy Creek, TX Cedar Creek, TX Cedar Park, TX Clarksville, TX Driftwood, TX Dripping Springs, TX Elgin, TX Georgetown, TX Granger, TX Hudson Bay, TX Hutto, TX Jollyville, TX Kyle, TX Lago Vista, TX Lakeway, TX Leander, TX Liberty Hill, TX Lost Creek, TX Manor, TX North Austin, TX NW Hills, TX Oak Hill, TX Pflugerville, TX Point Venture, TX Rollingwood, TX Round Rock, TX South Austin, TX Spicewood, TX Steiner Ranch, TX Taylor, TX The Hills, TX Travis Heights, TX West Lake Hills, TX Windemere, TX Wyldwood, TX 76527 (Florence) 76530 (Granger) 76537 (Jarrell) 76573 (Schwertner) 76574 (Taylor) 76578 (Thrall) 78602 (Bastrop) 78610 (Buda) 78612 (Cedar Creek) 78613 (Cedar Park) 78615 (Coupland) 78616 (Dale) 78617 (Del Valle) 78619 (Driftwood) 78620 (Dripping Springs) 78621 (Elgin) 78622 (Fentress) 78626 (Georgetown) 78628 (Georgetown) 78633 (Georgetown) 78634 (Hutto) 78640 (Kyle) 78641 (Leander) 78642 (Liberty Hill) 78644 (Lockhart) 78645 (Lago Vista) 78648 (Luling) 78650 (Mc Dade) 78652 (Manchaca) 78653 (Manor) 78655 (Martindale) 78656 (Maxwell) 78659 (Paige) 78660 (Pflugerville) 78661 (Prairie Lea) 78662 (Red Rock) 78664 (Round Rock) 78665 (Round Rock) 78666 (San Marcos) 78669 (Spicewood) 78676 (Wimberley) 78681 (Round Rock) 78701 | 78702 | 78703 | 78704 | 78705 | 78712 | 78717 | 78719 | 78721 | 78722 | 78723 | 78724 | 78725 (Hornsby Bend) 78726 | 78727 | 78728 (Wells Branch) 78729 (Jollyville) 78730 | 78731 | 78732 | 78733 | 78734 (Lakeway) 78735 | 78736 | 78737 | 78738 (Bee Cave) 78739 | 78741 | 78742 | 78744 | 78745 | 78746 | 78747 | 78748 | 78749 | 78750 | 78751 | 78752 | 78753 | 78754 | 78756 | 78757 | 78758 | 78759 | 78953 (Rosanky) 78957 (Smithville)
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quicktechweb · 7 years ago
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Georgetown Texas Finest Professional Voice & Data Cabling Network Solutions Contractor
Georgetown High Quality Voice and Data Structured Cabling Install and Repair Solutions Contractor.
US Cabling Pros provides high quality network voice and data cabling services throughout the city of Georgetown, in addition to the whole state of Texas. Our IT industry certified structured cabling pros provide voice and data structured cabling, installation, diagnosis & repair services. Whether you have a need for a single cable run or jack fixed, or simply need a complete structured cabling installation of 10 to 1000 drops, we have you covered. We supply superior quality on site high speed data cabling installs for large and small voice and data networks along with complete voice cabling solutions for PBX and VoIP installations. Our low voltage commercial business inside wiring technicians will gladly pull and terminate as many cables as you need throughout your old or new construction location, with picture perfect results, every time. We are Georgetown’s best choice for voice and data contracting solutions, so take a moment to give us a call today and let us show you what we can do for you and your Georgetown voice and data network (859) 780-3061.
Georgetown Texas Top Choice Professional Onsite Voice and Data Network Cabling Provider.
At US Cabling Pros, we fully comprehend that Basic data and fast, high quality telecom voice network infrastructure is the most basic fundamental ‘must have’ of modern commercial business operations. From keeping employees connected and in sync to public facing point of sale services, high speed data transmission over wired and wireless networks is an absolute basic requirement for any thriving business. As experienced and accomplished onsite tech service professionals, we absolutely respect the unwavering need for lightning fast, high quality voice and data networking with unhindered connectivity, and our highly experienced network techs are hands and feet on the ground in Georgetown every single day meeting and exceeding client requirements. From installing commercial voice systems and building out structured cabling wired networks throughout Georgetown, to installing and configuring network gear for our customers and providing fast voice and data network repair services whenever problems arise, we strive to be your onsite contract service pros. Our cabling industry accredited network hardware and cabling technicians are ready to take on your next project or onsite service need, and we will always provide for you the highly pro results that you require to keep your data network running strong well after our service visit is wrapped up. Whether you are looking for pro diagnosis and repair services on your present structured cabling, or comprehensive voice and data cabling installation services for a brand new or expanding location, we have you completely covered in Georgetown and throughout the entire state of Texas. Give us a phone call today and let us show you why so many Georgetown businesses rely on our professional voice and data network structured cabling on-site services when they need a reliable, honest professional structured cabling service contractor to keep their network and telephones running like brand new (859) 780-3061.
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Georgetown Texas Best Professional Low Voltage Inside Wiring, and Voice and Data Network Cabling Technicians.
From all the way back in 2008, US Cabling Pros have proudly been offering high quality onsite network and telecom and data low voltage copper inside wiring services to commercial customers throughout the beautiful city of Georgetown. Our high quality service solutions have been utilized in a wide array of commercial applications such as medical facilities, residential living, hospitality, industrial, retail and government, and by a wide variety of satisfied customers including general contractors, electrical project contractors, third party tech solutions suppliers, building and facility maintenance managers and small company owners who just need experienced network cabling service providers to install new cabling or repair existing voice and data infrastructure cabling on an as-needed basis or for large volume wiring projects. Our as-needed T&M solution is as easy as a phone call to our dispatch to request a cabling technician on site for you to take care of any kind of voice or data wiring job you might require. Feel free to reach out and give us a phone call now to discuss your present network problems as well as any upcoming network roll outs so that we can produce a custom inside wiring option for you and your Georgetown company (859) 780-3061.
Professional On-Site Tech Support Services On Call in Georgetown Texas.
US Cabling Pros of Georgetown
Georgetown, Texas 78626
(859) 780-3061
Looking for professional onsite computer and printer service and repair in Georgetown Texas? Check out our partner provider Computech Technology Services for all of your on site tech service needs – Computech Technology Services of Georgetown Texas.
http://www.uscablingpros.com/georgetown-texas-trusted-professional-voice-data-cabling-network-services-provider/
The post Georgetown Texas Finest Professional Voice & Data Cabling Network Solutions Contractor appeared first on Quick Tech Web.
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cometoyouautorepair · 4 years ago
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❇️ WANTED TO TAKE A MOMENT & GIVE A SPECIAL THANKS TO OUR AMAZING CUSTOMERS!! THIS IS WHAT MAKES ALL THE LONG HOT DAYS & COLD NIGHTS 24hr 7 DAYS A WEEK ALL WORTH IT WHEN SEEING WERE ABLE TO HELP SOMEONE ❇️
“ I had to take my time writing this review... I decided to approach it from a very raw and real stand point.
Sometimes there are moments or situations that happen in life that make us feel like we hit a brick wall. In those moments the most random people pop up and step forward to help just when they are needed.
On April 20, 2020 we lost my husbands brother to suicide. Time had already slowed with Covid-19 spreading, but on this day, the world stopped spinning for us. We stepped into what would be a tornado of emotions, pain, and hurt over the following weeks.
We had to figure out how to my brother-in-laws truck home along with his personal effects as we live 1,800 miles away from where he passed. We discovered that his truck had been sitting for a few months with a dead battery and was in desperate need of tlc to get running. The only way to get her (the truck is named ol' Betsy) her home was to drive her and pull the personal items home in a Uhaul. A truck that we had never laid eyes on and had been sitting for a few months. The thought of driving 1,800 miles home in it was just... well it scared the shit out of me. But, knew how absolutely imperative it was for my husband to have a piece of his brother. We had to get Betsy.
I searched around online from home in Arizona looking for a good mechanic in Lexington. I crossed Come To You Auto Repair and gave them a call. A man named Rob answered. I started telling him this story... about the death, the hurt, the truck , the things... I cried a little and apologized for the emotion. And you know what? He listened with compassion. COMPASSION. He cared. About it all. He took the job and headed to work on the truck before our arrival to drive her home. After a few days, Rob had it done. No overcharging, no bumping up prices on parts, answered EVERY QUESTION and EVERY PHONE CALL....
So, we get there on June 3. Truck was all good. We drove her home. !,889 miles in Ol' Betsy. Rob checked on us daily to make sure we were ok throughout our journey as we broke up the miles per day. Compassion and care.
I don't know what to say as I am choked up now writing this. It was all an emotional journey.
Rob, I told you to thank your mother for me, and I meant that. You are a kind, hard-working, good soul. I appreciate everything that you did for us. We sincerely wish you ALL the best with your business and in life. You deserve it!!! “
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Servicing Kentucky Lexington,Frankfort,Georgetown, Louisville, Paris, Sadieville, Richmond, Cynthiana, Brea, Lawrenceburg, & more
Brakes, water pump, alternator, wheel bearings, semi truck and trailers, emergency roadside repair, diesel repair on site repair, heavy equipment, tune up, cars, trucks, suv, mechanic that comes to me, mobile mechanic.
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#Transmission and Drivetrain
#Axle Assembly Replacement
#CV Joint Boot Replacement
#CV Joint Replacement
#CV Axle Assembly Replacement
#Driveshaft Replacement
#Transfer Case Fluid Replacement
#Transmission Fluid Change
0 notes
jerrytackettca · 6 years ago
Text
The Gut's Role in Parkinson's Disease
Parkinson's disease is a neurological disorder in which neurons and dopamine-producing cells in your brain begin to die. Symptoms progress over time and include tremors, slow movements, rigid limbs, shuffling gait, stooped posture and an inability to move. Patients may also experience a reduced ability to make facial expressions.
While patients suffer significant physical disability, the condition may also trigger depression, speech impediments and personality changes. There is also an association with dementia. Parkinson’s affects as many as 7 million to 10 million adults worldwide, and approximately 60,000 Americans are diagnosed with Parkinson's every year.1
Although incidence of the disease increases with age, an estimated 4 percent of those with Parkinson's are diagnosed before the age of 50. Men are 1.5 times more likely to have Parkinson's than women, and treatment can be expensive. Medications can an average $2,500 a year, while therapeutic surgery may cost up to $100,000 per patient.
A recent study2 published in the Journal of Parkinson's Disease once again demonstrates an association between the development of this neurological disease and your gut microbiome.
The featured study focused on alpha-synuclein pathology, biomarkers and gut microbiome, and as other studies3 found alpha-synuclein plays a role in the development of familial and sporadic cases of Parkinson's disease.
Research Highlights Gut-Brain Link in Parkinson’s Disease
Unfortunately diagnosis often occurs after brain cells have already been affected and died. For this reason, it's more difficult to slow the progression of the disease, so researchers have been investigating ways to detect the condition earlier, which might positively impact treatment.
Past studies have demonstrated a link between the gut microbiome and Parkinson's disease. This current review paper set out to investigate the most recent research available on this gut-brain connection.
Lead author Dr. Filip Scheperjans, from the department of neurology at the Helsinki University Hospital in Finland, believes understanding the role the gut plays in the development of the disease will help improve treatment.4
The review evaluated the involvement of an abnormal amount of protein aggregates associated with local inflammation and the impact on the gut microbiome. As noted by Scheperjans:5
“Our understanding and appreciation of the importance of the gut-brain connection in [Parkinson's have] grown rapidly in recent years. We are confident that the coming two decades of microbiome-gut-brain-axis research will see an even accelerated development in this area that will reshape our understanding of the pathogenesis of [Parkinson's]."
To this aim, the authors identified four key research areas where additional focus is needed:6 
Although deposits of alpha-synuclein have been found in the enteric nervous system of people suffering from Parkinson's disease, more research is needed to determine if these aggregates are similar to ones found in the brains of Parkinson’s patients.
Research has theorized intestinal hyperpermeability may be what triggers the aggregation in the enteric nerves. The researchers suggest further study should focus on whether those with Parkinson's also have a higher intestinal permeability.
Utilizing immunohistochemistry to study alpha synuclein aggregates in the enteric nervous system has yielded mixed results, leading the authors to suggest alternative methods of detecting aggregate deposits in the gut should be developed.
The authors suggest large multicenter studies of individuals with Parkinson's, as well as animal studies, are necessary to definitively identify the mechanism underlying the connection between the gut and Parkinson's disease.
Protein Aggregates May Start in the Brain and Travel to the Gut
Alpha-synuclein is a presynaptic protein linked neuropathologically and genetically to Parkinson's disease.7 While it may contribute to symptoms in a number of ways, the aberrant cells are toxic to cellular homeostasis, triggering neuronal death and affecting synaptic function.
Secreted alpha-synuclein may have negative effects on neighboring cells, including seeding aggregations, which contributes to progression of the disease. Detection of alpha-synuclein lesions in peripheral tissues has important clinical implications in the brain and peripheral organs.
Researchers have sought to identify potential pathways involved in the long-distance transfer of the protein from the brain to the gut, where it is found in those suffering from Parkinson’s disease. Although researchers have identified the alpha-synuclein protein in the development of the disease, the real function before the disease is triggered had remained a mystery.
Using a mouse model, researchers8 found increasing the expression of alpha-synuclein inhibited the mechanism of releasing neurotransmitters, essentially producing Parkinsonian symptoms. At normal levels however, the protein accelerated the release of these molecules if it was already occurring.
In another rat study,9 researchers were able to identify a specific transmission of the protein from the brain to the stomach. As explained by the authors:
“Following targeted midbrain overexpression of human alpha-synuclein, the exogenous protein was capable of reaching the gastric wall where it was accumulated into preganglionic vagal terminals.
This brain-to-stomach connection likely involved intra- and interneuronal transfer of non-fibrillar alpha-synuclein that first reached the medulla oblongata, then gained access into cholinergic neurons of the dorsal motor nucleus of the vagus nerve and finally traveled via efferent fibers of these neurons contained within the vagus nerve.”
The researchers believe the dorsal motor nucleus of the vagus nerve is a key relay center for transmission of alpha-synuclein proteins from central to peripheral locations. The presence of these proteins may represent an ongoing pathological process originating within the brain that can then affect other organs innervated by the motor vagal nerve.
Autophagy Defects Contribute to Parkinson’s Disease
Currently there is no cure for Parkinson's disease. In one study,10 researchers described aspects of the disease as suppression of the autosomal-lysomal autophagy system, a systemic degradation of your body’s functional components due to cell destruction, characterized by the loss of dopamine transmitting neurons in a section of the midbrain.11
By activating autophagy, in essence repairing the dysfunctional mechanism, researchers believe neurodegenerative diseases may be successfully treated. Autophagy literally means “self-eating” and refers to the process of eliminating damaged cells by digesting them.
It is a cleaning out process that encourages the growth of new healthy cells and is foundational to cellular rejuvenation and longevity. Researchers explain the process in a paper published in Nature Reviews Drug Discovery,12 saying the pathway is involved in a variety of human health conditions, including metabolic disorders, neurodegenerative diseases, cancer and infectious diseases.
In response, there has been considerable pharmacological interest in inhibiting the pathway and upregulating autophagy as a means of therapeutically benefiting those with neurodegenerative diseases. In essence, this would clear out harmful protein aggregates that trigger symptoms and disease progression.
Research has demonstrated specific cancer drugs can trigger autophagy by activating a protein called parkin.13 Charbel Moussa, assistant professor of neurology at Georgetown University, talks about the delicate balance involved when medicine attempts to manipulate cell processes:14
“Activating autophagy is a double-edged sword. One [sic] the one hand, the process clears toxic or infectious materials from cells. On the other hand, if the autophagy process goes beyond 'recycling' and clearing out proteins, it can start to destroy the cell, leading to cell death.
This means that autophagy must be carefully manipulated to avoid the death of nonrenewable and irreplaceable neurons."
The good news is you don’t have to wait for a drug to be developed to improve autophagy. One of the easiest ways to do this is through fasting, which I discuss further below.
Annual Legume May Help Treat Parkinson’s Disease Naturally
Mucuna pruriens (M. pruriens) is a climbing legume best known as a natural source of L-dopa, a dopamine precursor that affects energy, motivation and well-being, and is often used in the treatment of Parkinson's disease in Ayurvedic medicine.
M. pruriens is a well-known source of protein in tropical areas of the world. Also known as the velvet bean, kapikacchu and cowhage seed, these legumes are a vigorous, annual plant, boasting nearly 100 different varieties. The legume originated in southern China and Eastern India, but now grows in tropical areas worldwide.
The plant has dark brown or speckled seed pods that are about 4 inches long and contain four to six seeds each. Although the bean is highly beneficial, contact with the pod may result in severe skin irritation and itching. When the beans are used for food, they are soaked until they sprout, then boiled and ground into a paste used in cooking.15
When used medicinally, the beans are boiled to remove the enzyme coat, then strained and dried. The kernels are ground into a fine powder commonly mixed with water and taken orally. The practice of using M. pruriens can be traced back thousands of years within the practice of Ayurvedic medicine.
The seeds are roughly 4 to 7 percent L-dopa, which easily crosses your blood-brain barrier, accounting for the interest in those seeking natural treatments for Parkinson's disease.16
Although clinical trials have demonstrated its ability to produce equivalent or better results than medications, without side effects, Western medicine continues to use and promote a synthetic form of L-dopa in the treatment of Parkinson's disease.
If you have the disease and would like to investigate this natural treatment, consult with your doctor or an Ayurvedic medicine practitioner before taking M. pruriens, especially if you are currently taking prescription medication, to ensure this remedy is right for you.
It may also be possible to prevent neurodegenerative diseases or reduce symptoms by addressing your gut permeability and autophagy dysfunction through natural means.
How to Decrease Your Gut Permeability
Your gut microbiome is an important part of the future of medicine. Nearly 15 years ago scientists believed the Human Genome Project would find information necessary to create gene-based therapies to produce cures for most health conditions.
Now science has learned genetics are responsible for only 10 percent of all human disease, while the remaining 90 percent are triggered by environmental factors.17 With further research and study, science is now coming to realize your gut microbiome is actually driving genetic expression, turning genes on and off depending upon which microbes are present in your gut.
You can improve the health of your gut microbiome, and thus may make significant changes to your health, through small lifestyle changes, such as eliminating sugar, using a cyclical ketogenic diet and including plenty of fiber rich foods.
For a list of simple changes to your lifestyle you may consider to optimize your microbiome and reduce your potential for disease, see my article, "Gut Microbiome May Be a Game-Changer for Cancer Prevention and Treatment."
How to Improve Autophagy
Your body was built for periodic cycles of feast and famine. Through intermittent fasting, you can enjoy improved cardiovascular health, reduced cancer risk and better gene repair and longevity. Fasting also helps support your immune system function and has a beneficial impact on your brain function as well, by boosting brain derived neurotrophic factor (BDNF).
Depending upon the region of the brain you may experience a boost from 50 percent to 400 percent. BDNF activates stem cells to convert into new neurons and triggers numerous other chemicals promoting normal health. This protein also protects brain cells from changes associated with Parkinson's and Alzheimer's disease.
Fasting is a powerful way to activate autophagy, but should not be done willy-nilly. If you are on medication, you need to work with your doctor to ensure safety as some medications need to be taken with food. Diabetics who are on medication also need to use caution and work with a health professional as they may need to adjust their medication dosage to avoid adverse effects. I also recommend you continue taking nutritional supplements and to take a high-quality salt.
One of the reasons I’ve reverted back to advising caution with water-only fasting is because multiday water fasting is very effective at liberating stored toxins from your fat, which can cause problems if your detoxification system isn’t properly supported.
While I’ve done several five-day water-only fasts in the past, I’ve now switched to a partial fast that supplies many of the nutrients your body needs to support your detox pathways instead. It involves a base of intermittent fasting for 16 to 18 hours, and once or twice a week you have a 300- to 800-calorie meal loaded with detox supporting nutrients, followed by a 24-hour fast. So, in essence, you’re then only eating one 300- to 800-calorie meal in 42 hours.
Using an infrared sauna and taking effective binders, like chlorella, modified citrus pectin, cilantro and even activated charcoal can help eliminate liberated toxins from your body and prevent their reabsorption.
A gentler way to still improve autophagy is daily intermittent fasting, providing you are not eating for at least 16 hours. You can also activate autophagy by alternating high intensity interval training or resistance training with a day of rest.
Activating adenosine monophosphate-activated protein kinase (AMPK) through proper diet and nutritional supplements also supports natural autophagy. You can learn more about this process in my previous article, “Autophagy Finally Considered for Disease Treatment.”
from http://articles.mercola.com/sites/articles/archive/2019/02/28/parkinsons-gut-bacteria.aspx
source http://niapurenaturecom.weebly.com/blog/the-guts-role-in-parkinsons-disease
0 notes
jakehglover · 6 years ago
Text
The Gut's Role in Parkinson's Disease
Parkinson's disease is a neurological disorder in which neurons and dopamine-producing cells in your brain begin to die. Symptoms progress over time and include tremors, slow movements, rigid limbs, shuffling gait, stooped posture and an inability to move. Patients may also experience a reduced ability to make facial expressions.
While patients suffer significant physical disability, the condition may also trigger depression, speech impediments and personality changes. There is also an association with dementia. Parkinson’s affects as many as 7 million to 10 million adults worldwide, and approximately 60,000 Americans are diagnosed with Parkinson's every year.1
Although incidence of the disease increases with age, an estimated 4 percent of those with Parkinson's are diagnosed before the age of 50. Men are 1.5 times more likely to have Parkinson's than women, and treatment can be expensive. Medications can an average $2,500 a year, while therapeutic surgery may cost up to $100,000 per patient.
A recent study2 published in the Journal of Parkinson's Disease once again demonstrates an association between the development of this neurological disease and your gut microbiome.
The featured study focused on alpha-synuclein pathology, biomarkers and gut microbiome, and as other studies3 found alpha-synuclein plays a role in the development of familial and sporadic cases of Parkinson's disease.
Research Highlights Gut-Brain Link in Parkinson’s Disease
Unfortunately diagnosis often occurs after brain cells have already been affected and died. For this reason, it's more difficult to slow the progression of the disease, so researchers have been investigating ways to detect the condition earlier, which might positively impact treatment.
Past studies have demonstrated a link between the gut microbiome and Parkinson's disease. This current review paper set out to investigate the most recent research available on this gut-brain connection.
Lead author Dr. Filip Scheperjans, from the department of neurology at the Helsinki University Hospital in Finland, believes understanding the role the gut plays in the development of the disease will help improve treatment.4
The review evaluated the involvement of an abnormal amount of protein aggregates associated with local inflammation and the impact on the gut microbiome. As noted by Scheperjans:5
“Our understanding and appreciation of the importance of the gut-brain connection in [Parkinson's have] grown rapidly in recent years. We are confident that the coming two decades of microbiome-gut-brain-axis research will see an even accelerated development in this area that will reshape our understanding of the pathogenesis of [Parkinson's]."
To this aim, the authors identified four key research areas where additional focus is needed:6 
Although deposits of alpha-synuclein have been found in the enteric nervous system of people suffering from Parkinson's disease, more research is needed to determine if these aggregates are similar to ones found in the brains of Parkinson’s patients.
Research has theorized intestinal hyperpermeability may be what triggers the aggregation in the enteric nerves. The researchers suggest further study should focus on whether those with Parkinson's also have a higher intestinal permeability.
Utilizing immunohistochemistry to study alpha synuclein aggregates in the enteric nervous system has yielded mixed results, leading the authors to suggest alternative methods of detecting aggregate deposits in the gut should be developed.
The authors suggest large multicenter studies of individuals with Parkinson's, as well as animal studies, are necessary to definitively identify the mechanism underlying the connection between the gut and Parkinson's disease.
Protein Aggregates May Start in the Brain and Travel to the Gut
Alpha-synuclein is a presynaptic protein linked neuropathologically and genetically to Parkinson's disease.7 While it may contribute to symptoms in a number of ways, the aberrant cells are toxic to cellular homeostasis, triggering neuronal death and affecting synaptic function.
Secreted alpha-synuclein may have negative effects on neighboring cells, including seeding aggregations, which contributes to progression of the disease. Detection of alpha-synuclein lesions in peripheral tissues has important clinical implications in the brain and peripheral organs.
Researchers have sought to identify potential pathways involved in the long-distance transfer of the protein from the brain to the gut, where it is found in those suffering from Parkinson’s disease. Although researchers have identified the alpha-synuclein protein in the development of the disease, the real function before the disease is triggered had remained a mystery.
Using a mouse model, researchers8 found increasing the expression of alpha-synuclein inhibited the mechanism of releasing neurotransmitters, essentially producing Parkinsonian symptoms. At normal levels however, the protein accelerated the release of these molecules if it was already occurring.
In another rat study,9 researchers were able to identify a specific transmission of the protein from the brain to the stomach. As explained by the authors:
“Following targeted midbrain overexpression of human alpha-synuclein, the exogenous protein was capable of reaching the gastric wall where it was accumulated into preganglionic vagal terminals.
This brain-to-stomach connection likely involved intra- and interneuronal transfer of non-fibrillar alpha-synuclein that first reached the medulla oblongata, then gained access into cholinergic neurons of the dorsal motor nucleus of the vagus nerve and finally traveled via efferent fibers of these neurons contained within the vagus nerve.”
The researchers believe the dorsal motor nucleus of the vagus nerve is a key relay center for transmission of alpha-synuclein proteins from central to peripheral locations. The presence of these proteins may represent an ongoing pathological process originating within the brain that can then affect other organs innervated by the motor vagal nerve.
Autophagy Defects Contribute to Parkinson’s Disease
Currently there is no cure for Parkinson's disease. In one study,10 researchers described aspects of the disease as suppression of the autosomal-lysomal autophagy system, a systemic degradation of your body’s functional components due to cell destruction, characterized by the loss of dopamine transmitting neurons in a section of the midbrain.11
By activating autophagy, in essence repairing the dysfunctional mechanism, researchers believe neurodegenerative diseases may be successfully treated. Autophagy literally means “self-eating” and refers to the process of eliminating damaged cells by digesting them.
It is a cleaning out process that encourages the growth of new healthy cells and is foundational to cellular rejuvenation and longevity. Researchers explain the process in a paper published in Nature Reviews Drug Discovery,12 saying the pathway is involved in a variety of human health conditions, including metabolic disorders, neurodegenerative diseases, cancer and infectious diseases.
In response, there has been considerable pharmacological interest in inhibiting the pathway and upregulating autophagy as a means of therapeutically benefiting those with neurodegenerative diseases. In essence, this would clear out harmful protein aggregates that trigger symptoms and disease progression.
Research has demonstrated specific cancer drugs can trigger autophagy by activating a protein called parkin.13 Charbel Moussa, assistant professor of neurology at Georgetown University, talks about the delicate balance involved when medicine attempts to manipulate cell processes:14
“Activating autophagy is a double-edged sword. One [sic] the one hand, the process clears toxic or infectious materials from cells. On the other hand, if the autophagy process goes beyond 'recycling' and clearing out proteins, it can start to destroy the cell, leading to cell death.
This means that autophagy must be carefully manipulated to avoid the death of nonrenewable and irreplaceable neurons."
The good news is you don’t have to wait for a drug to be developed to improve autophagy. One of the easiest ways to do this is through fasting, which I discuss further below.
Annual Legume May Help Treat Parkinson’s Disease Naturally
Mucuna pruriens (M. pruriens) is a climbing legume best known as a natural source of L-dopa, a dopamine precursor that affects energy, motivation and well-being, and is often used in the treatment of Parkinson's disease in Ayurvedic medicine.
M. pruriens is a well-known source of protein in tropical areas of the world. Also known as the velvet bean, kapikacchu and cowhage seed, these legumes are a vigorous, annual plant, boasting nearly 100 different varieties. The legume originated in southern China and Eastern India, but now grows in tropical areas worldwide.
The plant has dark brown or speckled seed pods that are about 4 inches long and contain four to six seeds each. Although the bean is highly beneficial, contact with the pod may result in severe skin irritation and itching. When the beans are used for food, they are soaked until they sprout, then boiled and ground into a paste used in cooking.15
When used medicinally, the beans are boiled to remove the enzyme coat, then strained and dried. The kernels are ground into a fine powder commonly mixed with water and taken orally. The practice of using M. pruriens can be traced back thousands of years within the practice of Ayurvedic medicine.
The seeds are roughly 4 to 7 percent L-dopa, which easily crosses your blood-brain barrier, accounting for the interest in those seeking natural treatments for Parkinson's disease.16
Although clinical trials have demonstrated its ability to produce equivalent or better results than medications, without side effects, Western medicine continues to use and promote a synthetic form of L-dopa in the treatment of Parkinson's disease.
If you have the disease and would like to investigate this natural treatment, consult with your doctor or an Ayurvedic medicine practitioner before taking M. pruriens, especially if you are currently taking prescription medication, to ensure this remedy is right for you.
It may also be possible to prevent neurodegenerative diseases or reduce symptoms by addressing your gut permeability and autophagy dysfunction through natural means.
How to Decrease Your Gut Permeability
Your gut microbiome is an important part of the future of medicine. Nearly 15 years ago scientists believed the Human Genome Project would find information necessary to create gene-based therapies to produce cures for most health conditions.
Now science has learned genetics are responsible for only 10 percent of all human disease, while the remaining 90 percent are triggered by environmental factors.17 With further research and study, science is now coming to realize your gut microbiome is actually driving genetic expression, turning genes on and off depending upon which microbes are present in your gut.
You can improve the health of your gut microbiome, and thus may make significant changes to your health, through small lifestyle changes, such as eliminating sugar, using a cyclical ketogenic diet and including plenty of fiber rich foods.
For a list of simple changes to your lifestyle you may consider to optimize your microbiome and reduce your potential for disease, see my article, "Gut Microbiome May Be a Game-Changer for Cancer Prevention and Treatment."
How to Improve Autophagy
Your body was built for periodic cycles of feast and famine. Through intermittent fasting, you can enjoy improved cardiovascular health, reduced cancer risk and better gene repair and longevity. Fasting also helps support your immune system function and has a beneficial impact on your brain function as well, by boosting brain derived neurotrophic factor (BDNF).
Depending upon the region of the brain you may experience a boost from 50 percent to 400 percent. BDNF activates stem cells to convert into new neurons and triggers numerous other chemicals promoting normal health. This protein also protects brain cells from changes associated with Parkinson's and Alzheimer's disease.
Fasting is a powerful way to activate autophagy, but should not be done willy-nilly. If you are on medication, you need to work with your doctor to ensure safety as some medications need to be taken with food. Diabetics who are on medication also need to use caution and work with a health professional as they may need to adjust their medication dosage to avoid adverse effects. I also recommend you continue taking nutritional supplements and to take a high-quality salt.
One of the reasons I’ve reverted back to advising caution with water-only fasting is because multiday water fasting is very effective at liberating stored toxins from your fat, which can cause problems if your detoxification system isn’t properly supported.
While I’ve done several five-day water-only fasts in the past, I’ve now switched to a partial fast that supplies many of the nutrients your body needs to support your detox pathways instead. It involves a base of intermittent fasting for 16 to 18 hours, and once or twice a week you have a 300- to 800-calorie meal loaded with detox supporting nutrients, followed by a 24-hour fast. So, in essence, you’re then only eating one 300- to 800-calorie meal in 42 hours.
Using an infrared sauna and taking effective binders, like chlorella, modified citrus pectin, cilantro and even activated charcoal can help eliminate liberated toxins from your body and prevent their reabsorption.
A gentler way to still improve autophagy is daily intermittent fasting, providing you are not eating for at least 16 hours. You can also activate autophagy by alternating high intensity interval training or resistance training with a day of rest.
Activating adenosine monophosphate-activated protein kinase (AMPK) through proper diet and nutritional supplements also supports natural autophagy. You can learn more about this process in my previous article, “Autophagy Finally Considered for Disease Treatment.”
from HealthyLife via Jake Glover on Inoreader http://articles.mercola.com/sites/articles/archive/2019/02/28/parkinsons-gut-bacteria.aspx
0 notes
paullassiterca · 6 years ago
Text
The Gut's Role in Parkinson's Disease
Parkinson’s disease is a neurological disorder in which neurons and dopamine-producing cells in your brain begin to die. Symptoms progress over time and include tremors, slow movements, rigid limbs, shuffling gait, stooped posture and an inability to move. Patients may also experience a reduced ability to make facial expressions.
While patients suffer significant physical disability, the condition may also trigger depression, speech impediments and personality changes. There is also an association with dementia. Parkinson’s affects as many as 7 million to 10 million adults worldwide, and approximately 60,000 Americans are diagnosed with Parkinson’s every year.1
Although incidence of the disease increases with age, an estimated 4 percent of those with Parkinson’s are diagnosed before the age of 50. Men are 1.5 times more likely to have Parkinson’s than women, and treatment can be expensive. Medications can an average $2,500 a year, while therapeutic surgery may cost up to $100,000 per patient.
A recent study2 published in the Journal of Parkinson’s Disease once again demonstrates an association between the development of this neurological disease and your gut microbiome.
The featured study focused on alpha-synuclein pathology, biomarkers and gut microbiome, and as other studies3 found alpha-synuclein plays a role in the development of familial and sporadic cases of Parkinson’s disease.
Research Highlights Gut-Brain Link in Parkinson’s Disease
Unfortunately diagnosis often occurs after brain cells have already been affected and died. For this reason, it’s more difficult to slow the progression of the disease, so researchers have been investigating ways to detect the condition earlier, which might positively impact treatment.
Past studies have demonstrated a link between the gut microbiome and Parkinson’s disease. This current review paper set out to investigate the most recent research available on this gut-brain connection.
Lead author Dr. Filip Scheperjans, from the department of neurology at the Helsinki University Hospital in Finland, believes understanding the role the gut plays in the development of the disease will help improve treatment.4
The review evaluated the involvement of an abnormal amount of protein aggregates associated with local inflammation and the impact on the gut microbiome. As noted by Scheperjans:5
“Our understanding and appreciation of the importance of the gut-brain connection in [Parkinson’s have] grown rapidly in recent years. We are confident that the coming two decades of microbiome-gut-brain-axis research will see an even accelerated development in this area that will reshape our understanding of the pathogenesis of [Parkinson’s].“
To this aim, the authors identified four key research areas where additional focus is needed:6 
Although deposits of alpha-synuclein have been found in the enteric nervous system of people suffering from Parkinson’s disease, more research is needed to determine if these aggregates are similar to ones found in the brains of Parkinson’s patients.
Research has theorized intestinal hyperpermeability may be what triggers the aggregation in the enteric nerves. The researchers suggest further study should focus on whether those with Parkinson’s also have a higher intestinal permeability.
Utilizing immunohistochemistry to study alpha synuclein aggregates in the enteric nervous system has yielded mixed results, leading the authors to suggest alternative methods of detecting aggregate deposits in the gut should be developed.
The authors suggest large multicenter studies of individuals with Parkinson’s, as well as animal studies, are necessary to definitively identify the mechanism underlying the connection between the gut and Parkinson’s disease.
Protein Aggregates May Start in the Brain and Travel to the Gut
Alpha-synuclein is a presynaptic protein linked neuropathologically and genetically to Parkinson’s disease.7 While it may contribute to symptoms in a number of ways, the aberrant cells are toxic to cellular homeostasis, triggering neuronal death and affecting synaptic function.
Secreted alpha-synuclein may have negative effects on neighboring cells, including seeding aggregations, which contributes to progression of the disease. Detection of alpha-synuclein lesions in peripheral tissues has important clinical implications in the brain and peripheral organs.
Researchers have sought to identify potential pathways involved in the long-distance transfer of the protein from the brain to the gut, where it is found in those suffering from Parkinson’s disease. Although researchers have identified the alpha-synuclein protein in the development of the disease, the real function before the disease is triggered had remained a mystery.
Using a mouse model, researchers8 found increasing the expression of alpha-synuclein inhibited the mechanism of releasing neurotransmitters, essentially producing Parkinsonian symptoms. At normal levels however, the protein accelerated the release of these molecules if it was already occurring.
In another rat study,9 researchers were able to identify a specific transmission of the protein from the brain to the stomach. As explained by the authors:
“Following targeted midbrain overexpression of human alpha-synuclein, the exogenous protein was capable of reaching the gastric wall where it was accumulated into preganglionic vagal terminals.
This brain-to-stomach connection likely involved intra- and interneuronal transfer of non-fibrillar alpha-synuclein that first reached the medulla oblongata, then gained access into cholinergic neurons of the dorsal motor nucleus of the vagus nerve and finally traveled via efferent fibers of these neurons contained within the vagus nerve.”
The researchers believe the dorsal motor nucleus of the vagus nerve is a key relay center for transmission of alpha-synuclein proteins from central to peripheral locations. The presence of these proteins may represent an ongoing pathological process originating within the brain that can then affect other organs innervated by the motor vagal nerve.
Autophagy Defects Contribute to Parkinson’s Disease
Currently there is no cure for Parkinson’s disease. In one study,10 researchers described aspects of the disease as suppression of the autosomal-lysomal autophagy system, a systemic degradation of your body’s functional components due to cell destruction, characterized by the loss of dopamine transmitting neurons in a section of the midbrain.11
By activating autophagy, in essence repairing the dysfunctional mechanism, researchers believe neurodegenerative diseases may be successfully treated. Autophagy literally means “self-eating” and refers to the process of eliminating damaged cells by digesting them.
It is a cleaning out process that encourages the growth of new healthy cells and is foundational to cellular rejuvenation and longevity. Researchers explain the process in a paper published in Nature Reviews Drug Discovery,12 saying the pathway is involved in a variety of human health conditions, including metabolic disorders, neurodegenerative diseases, cancer and infectious diseases.
In response, there has been considerable pharmacological interest in inhibiting the pathway and upregulating autophagy as a means of therapeutically benefiting those with neurodegenerative diseases. In essence, this would clear out harmful protein aggregates that trigger symptoms and disease progression.
Research has demonstrated specific cancer drugs can trigger autophagy by activating a protein called parkin.13 Charbel Moussa, assistant professor of neurology at Georgetown University, talks about the delicate balance involved when medicine attempts to manipulate cell processes:14
“Activating autophagy is a double-edged sword. One [sic] the one hand, the process clears toxic or infectious materials from cells. On the other hand, if the autophagy process goes beyond ‘recycling’ and clearing out proteins, it can start to destroy the cell, leading to cell death.
This means that autophagy must be carefully manipulated to avoid the death of nonrenewable and irreplaceable neurons.”
The good news is you don’t have to wait for a drug to be developed to improve autophagy. One of the easiest ways to do this is through fasting, which I discuss further below.
Annual Legume May Help Treat Parkinson’s Disease Naturally
Mucuna pruriens (M. pruriens) is a climbing legume best known as a natural source of L-dopa, a dopamine precursor that affects energy, motivation and well-being, and is often used in the treatment of Parkinson’s disease in Ayurvedic medicine.
M. pruriens is a well-known source of protein in tropical areas of the world. Also known as the velvet bean, kapikacchu and cowhage seed, these legumes are a vigorous, annual plant, boasting nearly 100 different varieties. The legume originated in southern China and Eastern India, but now grows in tropical areas worldwide.
The plant has dark brown or speckled seed pods that are about 4 inches long and contain four to six seeds each. Although the bean is highly beneficial, contact with the pod may result in severe skin irritation and itching. When the beans are used for food, they are soaked until they sprout, then boiled and ground into a paste used in cooking.15
When used medicinally, the beans are boiled to remove the enzyme coat, then strained and dried. The kernels are ground into a fine powder commonly mixed with water and taken orally. The practice of using M. pruriens can be traced back thousands of years within the practice of Ayurvedic medicine.
The seeds are roughly 4 to 7 percent L-dopa, which easily crosses your blood-brain barrier, accounting for the interest in those seeking natural treatments for Parkinson’s disease.16
Although clinical trials have demonstrated its ability to produce equivalent or better results than medications, without side effects, Western medicine continues to use and promote a synthetic form of L-dopa in the treatment of Parkinson’s disease.
If you have the disease and would like to investigate this natural treatment, consult with your doctor or an Ayurvedic medicine practitioner before taking M. pruriens, especially if you are currently taking prescription medication, to ensure this remedy is right for you.
It may also be possible to prevent neurodegenerative diseases or reduce symptoms by addressing your gut permeability and autophagy dysfunction through natural means.
How to Decrease Your Gut Permeability
Your gut microbiome is an important part of the future of medicine. Nearly 15 years ago scientists believed the Human Genome Project would find information necessary to create gene-based therapies to produce cures for most health conditions.
Now science has learned genetics are responsible for only 10 percent of all human disease, while the remaining 90 percent are triggered by environmental factors.17 With further research and study, science is now coming to realize your gut microbiome is actually driving genetic expression, turning genes on and off depending upon which microbes are present in your gut.
You can improve the health of your gut microbiome, and thus may make significant changes to your health, through small lifestyle changes, such as eliminating sugar, using a cyclical ketogenic diet and including plenty of fiber rich foods.
For a list of simple changes to your lifestyle you may consider to optimize your microbiome and reduce your potential for disease, see my article, “Gut Microbiome May Be a Game-Changer for Cancer Prevention and Treatment.”
How to Improve Autophagy
Your body was built for periodic cycles of feast and famine. Through intermittent fasting, you can enjoy improved cardiovascular health, reduced cancer risk and better gene repair and longevity. Fasting also helps support your immune system function and has a beneficial impact on your brain function as well, by boosting brain derived neurotrophic factor (BDNF).
Depending upon the region of the brain you may experience a boost from 50 percent to 400 percent. BDNF activates stem cells to convert into new neurons and triggers numerous other chemicals promoting normal health. This protein also protects brain cells from changes associated with Parkinson’s and Alzheimer’s disease.
Fasting is a powerful way to activate autophagy, but should not be done willy-nilly. If you are on medication, you need to work with your doctor to ensure safety as some medications need to be taken with food. Diabetics who are on medication also need to use caution and work with a health professional as they may need to adjust their medication dosage to avoid adverse effects. I also recommend you continue taking nutritional supplements and to take a high-quality salt.
One of the reasons I’ve reverted back to advising caution with water-only fasting is because multiday water fasting is very effective at liberating stored toxins from your fat, which can cause problems if your detoxification system isn’t properly supported.
While I’ve done several five-day water-only fasts in the past, I’ve now switched to a partial fast that supplies many of the nutrients your body needs to support your detox pathways instead. It involves a base of intermittent fasting for 16 to 18 hours, and once or twice a week you have a 300- to 800-calorie meal loaded with detox supporting nutrients, followed by a 24-hour fast. So, in essence, you’re then only eating one 300- to 800-calorie meal in 42 hours.
Using an infrared sauna and taking effective binders, like chlorella, modified citrus pectin, cilantro and even activated charcoal can help eliminate liberated toxins from your body and prevent their reabsorption.
A gentler way to still improve autophagy is daily intermittent fasting, providing you are not eating for at least 16 hours. You can also activate autophagy by alternating high intensity interval training or resistance training with a day of rest.
Activating adenosine monophosphate-activated protein kinase (AMPK) through proper diet and nutritional supplements also supports natural autophagy. You can learn more about this process in my previous article, “Autophagy Finally Considered for Disease Treatment.”
from Articles http://articles.mercola.com/sites/articles/archive/2019/02/28/parkinsons-gut-bacteria.aspx source https://niapurenaturecom.tumblr.com/post/183111557996
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itsworn · 7 years ago
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1970 Challenger: Meet The First-Ever Non-Hack Hellcat Swap!
This Hellcat-powered 1970 Challenger RT/SE could be the ultimate melding of classic styling, modern performance, and comfort.
If you think back to your high school days, there’s likely at least one car you used to see on a regular basis that was sitting neglected in someone’s yard or under tree. You probably daydreamed about that car and wondered why on earth anyone would be so callous to treat it like that. You certainly wouldn’t. You would get it back on the road to its former glory. For Larry Rose, this ’70 Challenger RT/SE was that car. As a young man, he kept his eye on it as it sat neglected in a yard. He saw it every time he drove out to his grandma’s house in Georgetown, IL and he would just shake his head and then spend most of the rest of the drive thinking about it.
How hard could a Hellcat swap be? …The answer is really hard, and plenty expensive.”
In most cases, stories like this usually include a few attempts at inquiring about the car, always to be turned away with declarations that it’s not for sale. Larry’s story went much better though. He kept an eye on the Challenger, and in 1989, he got wind that the car was for sale for $3,500. The bad news was that a light pole had fallen across the hood and gone through the windshield. Still, Larry knew that was the car, so at the age of 17, the Challenger became the first one he ever bought.
The bad news was that a light pole had fallen across the hood and gone through the windshield. Still, Larry knew that was the car…”
Being a high school kid, money was tight, so Larry replaced the windshield and worked the fender back out as best as he could. He spent some time getting it reliable and drivable again, and the 383 Magnum, four-speed, Dana-rearend—equipped coupe was his ride for the last two years of high school. As you would expect, there were many nights spent cruising the local hot spots to see and be seen. On one of those trips, Larry even managed to catch the attention of a good-looking girl who he took to prom. He didn’t know it then, but she would eventually be his wife. Some say the cool car had a little something to do with that.
Larry even managed to catch the attention of a good-looking girl who he took to prom. He didn’t know it then, but she would eventually be his wife.”
Around 1990, Larry saved up enough from his job working at a pallet company after school to have a local shop swap on a fender, repair the hood, and spray on a new coat of Lime Green paint. Shortly thereafter, though, Larry went away to college and the Challenger went into storage for a few years. School comes first, but once he had time to devote to it again, the Challenger was back on the road, and at the drag strip. It was still running the stock drivetrain, and rowing gears down the track was fun, but to get more consistency Larry swapped in an automatic. Then to get more speed, he added a nitrous system. The Challenger remained in this form for the next few years, and was a force to be reckoned with.
The RT/SE moved back and forth from the front to the back burner through the late ’90s and early 2000s as life changed and other projects came and went, but around 2005 Larry started thinking about making some really big changes. The burgeoning pro touring movement was bringing on a surge of innovation in new products to make classic cars more powerful, better handling, and more fun. For all of its history so far, the Challenger had pretty much just been a straight-line car, but Larry was warming up to the idea of getting more well-rounded.
It’s not only one of the first fully operational Hellcat swaps, it’s one of the cleanest. Despite 45 years of difference, Larry Rose managed to make the swap look factory. Larry did retain A/C, but noted that the variable displacement compressor requires some rewiring to be compatible with the Vintage Air system in the Challenger.
While the 383 had been a great engine and taken a beating over the years, it was time for a freshening, so Larry took the opportunity to upgrade to a 440 6-pack. The automatic came out and a stick went back in, but instead of a four-speed, the Challenger got one more cruising leg from a five-speed swap. The really interesting stuff happened underneath the skin though. Rather than rebuild or upgrade the original suspension, Larry opted for a full Reilly Motorsports package with the AlterKtion system up front and the Street Lynx in the rear. To say this transformed the Challenger would be an understatement. It was like a whole new animal and Larry fell in love with it all over again and started driving it a lot more.
A donor Hellcat’s shifter, uConnect touch screen, push-button start, pedals (including electronic throttle control), and even the seats were seamlessly integrated into the classic Challenger’s interior.
While not all factory parameters are functioning, Larry did retained the touchscreen LCD from the Hellcat which allows selection of performance modes.
There are things you learn about a car the more you drive it, especially when you’ve become accustomed to the nice things modern cars offer. For example, while a 6-pack looks oh-so-cool when you pop the hood, keeping it perfectly tuned in all conditions can be a bit of a chore. Plus, it’s not exactly easy on fuel. Since Larry was enjoying driving the Challenger more and planning to attend the 2012 Hot Rod Power Tour, he started looking at fuel-injection options and settled on a FAST EZ-EFI system. Notwithstanding, even with the more precise fuel and ignition control, Larry discovered the often lower quality fuel available in rural areas caused a lot of spark knock, requiring him to stop and manually adjust the timing.
Larry and his wide Kara were sold on the Power Tour, so Larry decided that the next evolution of the Challenger needed to be in the direction of easy long-distance touring. He wasn’t willing to give up on performance however, not by a long shot. Thanks to the modular design of the AlterKtion K-member, Larry knew he could easily swap to a different engine family, including a Gen-III Hemi. After some planning sessions, Larry placed a call to Cleveland Power and Performance to get one of their running pallets with an ’08 6.1L Hemi and complete wiring harness. While he was at it, he figured it was a great time to add a Magnuson supercharger. To preempt grenading the five-speed, Larry ordered a Tremec six-speed to handle the grunt. Larry and Kara attended more Power Tours with the Challenger in this configuration, and Larry discovered how much fun a boosted Gen-III can be on the drag strip. We guess you could say that was his gateway to late-model drivetrain performance.
The three-piece Boze Alloy satin-black wheels look great and allowed Larry to spec them exactly to the offsets he needed to run massive tires front and rear. Similar in appearance to the Hellcat’s tuner wheel, they fit the theme perfectly.
That brings us to 2016. While all of those upgrades were cool, we know what you really want to know: How hard could a Hellcat swap be? If the Challenger already had a blown Gen-III in it, how hard could it be, right? Wrong. The answer is really hard, and plenty expensive. Even more so because of Larry’s choice of transmission.
While sitting in traffic on the 2016 Power Tour and getting a severe left leg workout, Larry looked over at Kara and stated, “We should just buy a new Hellcat with an automatic trans.” Kara shot that down stating that they really didn’t need another car. “Fair enough,” Larry thought, so he countered with, “Well, what about a Hellcat engine upgrade instead?” That sounded fine to Kara, so at literally the next gas stop, Larry called up Cleveland Power & Performance and asked to be placed on the waiting list for the next available running pallet with the eight-speed automatic. The next week, they called Larry back and said they had one ready to ship out, if he was sure he wanted it. Larry assured them he was, and the Hellcat pallet arrived at his shop literally ready to run. For a couple of months, Larry would crank it up on the pallet just to show it off to friends, but when it came time to actually put it in the Challenger, the headaches began, particularly pertaining to the TorqueFlite 8HP90.
For a couple of months, Larry would crank it up on the pallet just to show it off to friends, but when it came time to actually put it in the Challenger, the headaches began…”
Before the stick shift brigade gets their pitchforks, if you haven’t driven one, you’ve got no argument to stand on. The 8HP90 is a marvel and to be perfectly honest, the best transmission option for the Hellcat and easily among the best performance-oriented, non-dual clutch self-shifting transmissions on the market. Sure, there was a point in time where a manual transmission was the only way to go, but those days are gone.
Starting with the roots, the 8HP90 debuted in the BMW 760Li behind a V12 engine, so it was engineered for precision behind power. Weighing less than 10 pounds more than the five-speed automatic it replaces, the eight forward gears work to keep the Hellcat engine in its most efficient rpm range with tight ratios of 4.71, 3.14, 2.10, 1.67, 1.29, 1.00, 0.84 and 0.67:1, with a 3.30:1 Reverse. Thanks to that 4.71 first gear, the Hellcat uses a tiny 2.62:1 rear axle ratio, yet delivers a 12.34:1 torque multiplication factor in first gear. For perspective, to achieve the same value with a 1970 street-spec Hemi Challenger, the standard 2.45 first gear would require huge 4.88 gears. Eye opening, huh? And while six-speed drivers may enjoy the connected feeling they get from the stick shift and clutch pedal, there’s no beating the 160 milliseconds shifts in Track mode. And that, friends, is why Larry decided to enter untested waters and keep it for the swap.
We say “untested,” because the 8HP90 is not a currently supported swap. Yes, there are at least two swaps we know of running around with one, Roadkill’s General Mayhem and the Gas Monkey Garage 1967 Dodge Dart “Shartcat,” but that doesn’t mean the info is accessible out there for everyone. Also, it’s a different case if you don’t want to hack your car up as much as they did. So with no harness or ECU available other than the stock parts, trying to integrate 2015 systems with 1970, plus a few aftermarket systems, opens up a world of complications. As far as we know, Larry’s is one of the few Hellcat swaps currently drivable and he’s still about 95 percent of the way to having it all figured out. The only current nagging concern is the ECU defaulting to limp mode after 130 mph. Larry speculates it could be a VSS issue related to the 3.54 gears in the Dana 60 causing the ECU to believe the vehicle’s absolute speed is too high, which, if determined to be the case, creates another issue since no one produces a 2.62 gear set for a Dana 60. That’s also why you see the stunted power numbers in the Fast Facts, since the Challenger cannot hit full rpm on the dyno. Still, in current form, Larry reports the Challenger is totally drivable and road-trip reliable. If you’re looking for the easier route, Larry advises using a GM 4L60 series with a standalone controller.
Larry’s is one of the few Hellcat swaps currently drivable and he’s still about 95 percent of the way to having it all figured out.”
On the topic of “not supported,” the Hellcat technically isn’t either, because even though it’s a Gen-III Hemi, it’s most definitely not the same level of install. Even though Larry had already installed a 6.1, the Hellcat was not a direct drop-in. For one, because of the lines routed from the rear of the supercharger, the engine had to be moved forward ¾ inch. Then there’s the six heat exchangers and all the requisite plumbing. For example, to cool the intake air and maximize density, a 250-watt thermostatically controlled electric pump moves 45 liters of coolant per minute through two intercoolers built into the flanks of the supercharger and two radiators positioned at the front of the car. You can’t just shove them any old place they fit; they need strong airflow and Hellcat-equipped cars are designed with this in mind. In fact, when Larry spoke to Chrysler engineers at a show once, they said one of the biggest issues he would likely face would be getting enough airflow to the coolers to keep the Hellcat out of limp mode. Working within the envelope the ’70 offers, Larry’s solution was to position the coolers within the fenders for the best airflow and add slim auxiliary fans. While he has not attempted open-track use, this solution has been effective for regular street use and Power Tour.
Wiring is its own adventure with a swap like this. The complex multi-tiered electrical system in the production car features multiple computers that all retrieve data from each other. The challenge is figuring what you can eliminate and what you can’t. For example, disconnect the wheel-speed sensors and you’ll trigger a code and disable the traction control, stability control, and speedo, but the car would still be drivable. On the other hand, the car would not crank at all if the ABS module were unplugged. That’s why Larry’s Challenger has the Hellcat ABS module mounted and plugged in, even though it’s not actually doing anything. As for the rest of the wiring, Larry reached out to numerous resources to confirm what was critical to operation. If the Challenger had a modern dash swap, it would be lit up like a Christmas tree with warning lights from triggered codes, but none are mission critical.
You would never know from looking that Larry Rose’s 1970 Dodge Challenger RT/SE was packing a modern Hellcat Hemi and eight-speed automatic, and that it put down 617 hp to the tires at the Mopar Muscle Dyno Showdown sponsored by Petty’s Garage.
Despite the fact that it’s already a driver and has taken home the Mopar Muscle Editor’s Choice award at the 2017 Mopar Nats, the saga of the ’70 Hellcat is actually an ongoing one as Larry irons out the technical details to get his RT/SE as turnkey as a brand-new Challenger. The plan is to have all the details ironed out so that he can offer the swap to customers of his shop, Larry’s Automotive in Newburgh, IN, with minimal hassle and using only the necessary components. Plus, if you haven’t noticed by now, Larry loves to upgrade and change this car, so this is hardly the last iteration. If you want to see more technical build details and follow the progress, check out his Instagram @70Hellcat because even though the Challenger will be making 707-plus hp once the bugs are smashed, Larry hinted to us that he’s already pondering what he may do next to make it ever faster.
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austinmms · 3 years ago
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Truck Transmission Repair in Austin Texasmore information is at : http://mobilemechanicsaustin.com/truck-transmission-repair-near-me/Are you looking for Truck Transmission Repair In Austin Texas?  Austin Mobile Mechanic Service provides the Truck Transmission Repair   in the whole town. Our professional team with their skilled techniques and complete knowledge provides the services which are needed by customers. Whether you are stuck in the mid of the road or you are in an emergency and you need Truck Transmission Repair hen you can call us. Well, for the Truck Transmission Repair , we can provide you the best team for the services. For free estimates, contact us or book an appointment now. REQUEST FREE ESTIMATES Truck Transmission Repair in Austin Mobile Mechanic Service Austin Mobile Mechanic Service has over experienced in the automotive repair industry, and we know exactly how to handle your vehicle’s needs. Since running at optimum efficiency is essential to meet crucial deadlines, we take extra care to ensure that your truck is in better shape than ever when you get back on the road. Get in touch with us today to see what we can do for you. TRUCK TRANSMISSION REPAIR IN AUSTIN TEXASAUSTIN MOBILE MECHANIC SERVICEREQUEST MORE INFORMATION. CLICK HERE!OR CALL US!Service AreaAnderson Mill, TX Austin TX Barton Creek, TX Barton Hills, TX Bee Cave, TX Briarcliff, TX Brushy Creek, TX Cedar Creek, TX Cedar Park, TX Clarksville, TX Driftwood, TX Dripping Springs, TX Elgin, TX Georgetown, TX Granger, TX Hudson Bay, TX Hutto, TX Jollyville, TX Kyle, TX Lago Vista, TX Lakeway, TX Leander, TX Liberty Hill, TX Lost Creek, TX Manor, TX North Austin, TX NW Hills, TX Oak Hill, TX Pflugerville, TX Point Venture, TX Rollingwood, TX Round Rock, TX South Austin, TX Spicewood, TX Steiner Ranch, TX Taylor, TX The Hills, TX Travis Heights, TX West Lake Hills, TX Windemere, TX Wyldwood, TXZip Codes in Austin, Texas:76527 (Florence) 76530 (Granger) 76537 (Jarrell) 76573 (Schwertner) 76574 (Taylor) 76578 (Thrall) 78602 (Bastrop) 78610 (Buda) 78612 (Cedar Creek) 78613 (Cedar Park) 78615 (Coupland) 78616 (Dale) 78617 (Del Valle) 78619 (Driftwood) 78620 (Dripping Springs) 78621 (Elgin) 78622 (Fentress) 78626 (Georgetown) 78628 (Georgetown) 78633 (Georgetown) 78634 (Hutto) 78640 (Kyle) 78641 (Leander) 78642 (Liberty Hill) 78644 (Lockhart) 78645 (Lago Vista) 78648 (Luling) 78650 (Mc Dade) 78652 (Manchaca) 78653 (Manor) 78655 (Martindale) 78656 (Maxwell) 78659 (Paige) 78660 (Pflugerville) 78661 (Prairie Lea) 78662 (Red Rock) 78664 (Round Rock) 78665 (Round Rock) 78666 (San Marcos) 78669 (Spicewood) 78676 (Wimberley) 78681 (Round Rock) 78701 | 78702 | 78703 | 78704 | 78705 | 78712 | 78717 | 78719 | 78721 | 78722 | 78723 | 78724 | 78725 (Hornsby Bend) 78726 | 78727 | 78728 (Wells Branch) 78729 (Jollyville) 78730 | 78731 | 78732 | 78733 | 78734 (Lakeway) 78735 | 78736 | 78737 | 78738 (Bee Cave) 78739 | 78741 | 78742 | 78744 | 78745 | 78746 | 78747 | 78748 | 78749 | 78750 | 78751 | 78752 | 78753 | 78754 | 78756 | 78757 | 78758 | 78759 | 78953 (Rosanky) 78957 (Smithville)
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itsworn · 8 years ago
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Denny Merritt’s Salvaged Studebaker Pickup
The path to becoming a true automotive enthusiast can begin in several ways. Some folks embrace it as a fun way to pass time after retirement while others get bit by the bug when they first get their driver’s license. Then again, there are some who are born into the sport.
Dennis Merritt, owner of this beautiful 1948 Studebaker pickup truck, says he can trace his love for vehicles back to when he was about 8 years old. That’s when he first modified his bicycle to impress the girls. Now retired from his railroad career, Denny devotes full time to his business, Merritt Auto Repair in Georgetown, Indiana, first established back in 1987. Denny enjoys building custom cars for clients and creating unique additions to his own collection. Over the years he estimates he’s built more than a dozen for himself and has several current favorites, including a 1970 Barracuda, 1950 Buick sedan, 1940 Ford, 1971 El Camino, 1972 Avanti, and more. Did we mention that Denny likes to stay busy? He also runs a full-time wrecker service!
About the same time he discovered that he really didn’t need sleep, Denny decided that there was a gap in his collection that could only be filled by a vintage pickup truck. Believing that true creativity can only begin with something genuinely different, he eliminated the standard Ford and Chevy options, finally tracking down this 1948 Studebaker M5 pickup in Otter Tail, Minnesota. It was in such rough shape however that he had to continue the search, buying a second truck to make one good one. Denny’s original goal was simply to create an old shop truck but somewhere along the way, the truck spoke up, dictating an all-new plan. Obviously, Denny listened, saying with a smile, “I like to do it right and I can’t stand people putting junk together and calling it good.”
Work began on the Stude by boxing the original frame, adding RideTech air suspension front and rear, tubular A-arms up front, and a Fatman four-link to hold the Winters quick-change rear fitted with 2.74 gears. Denny swapped the original Champion 169ci flathead six and T9 Crash Box four-speed for a tried-and-true GM LS3 crate motor (376 ci with a 4L85E trans, a combination he’s used many times in the past. It was a tight squeeze but it fit. PRC created a custom radiator to keep the motor cool and Vintage Air FrontRunner pulleys energize the accessories. GM electronic ignition creates precisely timed explosions and Doug Thorley stainless steel headers follow up, dumping spent gases into a 2.5-inch polished system with dual Flowmasters. The V-8 sends an estimated 515 hp to the four-speed automatic, protected by a BeCool trans cooler. Everything is stainless steel underneath, including the shop-fabricated 18-gallon gas tank. Batteries and reserve tanks for the air suspension are hidden from view under the bed. The Flaming River rack-and-pinion steering teamed up with GM disc brakes create a potent handling package. The truck rolls on Billet Specialties Velocity rims, 18s up front and 20s in the rear. Since Denny is a Cooper Tires dealer, Cooper rubber puts the power to the ground.
Although everything went together nicely, Denny realized that his new powertrain created a unique situation. Blisteringly fast with the current tall rear end, he estimated the top speed of the rejuvenated truck could easily exceed 140 mph. With characteristic humor, he decided to rectify the situation.
“I figured that gear would eventually kill me so I swapped in a 4.11 instead!”
Now, he buys lots of new rear tires but fortunately having the dealership makes that issue a non-starter.
Body mods were next on the list and since the vintage lines were what attracted him to the Stude in the first place, Denny left most of the external design cues untouched. All four fenders however, were beyond reasonable repair and were replaced with 2-inch wider fiberglass versions. The distinctive Studebaker grille was painted body color and the bed was outfitted with curly maple planks separated by stainless steel strips. The firewall and inner fender panels were smoothed to showcase the modern LS and the valve covers now boast the Studebaker logo. Denny had the talented team at S&W Collision in Georgetown, Indiana, complete the bodywork and spray the custom mixed shade of “DeMerritt” Red.
Moving into the home stretch, the interior was last on the list. The dash was painted to match the exterior and feature custom gauges that blend the old with the new, thanks to Dakota Digital. They kept the vintage look on the outside while adding modern technology underneath. Lokar pedals and tall shifter, A/C from Vintage Air, and Alpine four-speaker stereo make the cab a fun place to be on road trips. The bench seat is a repurposed backseat from a salvage vehicle with the armrest retained and the dimensions cut to fit the Stude. The team at Ace Rod Shop in Fairfield, Illinois, added the dark brown and beige leather to the seat, headliner, and door panels, along with brown carpeting on the floor.
Denny’s original goal was to create an old shop truck but as you can see, he’s one of those who can’t settle for good enough.
“Everything I do eventually expands into something that I wasn’t planning on doing!”
The build took two years but he’s not complaining. It’s one of his favorites in an already-pristine collection and a regular Best of Show winner. Denny enjoys giving his trophies away to kids in order to get them started down the same path that he chose years before.
FACTS & FIGURES
1948 Studebaker M5 1/2-Ton Pickup | Dennis Merritt
CHASSIS Frame: Studebaker with boxed framerails Rearend / Ratio: Winters 10-bolt rear fitted with 2.74 gears. Rear suspension: Fatman four link, RideTech ShockWaves Rear brakes: GM disc brakes Front suspension: Flaming River tubular A-arms, RideTech ShockWaves Front brakes: GM disc brakes Steering box: Flaming River Front wheels: Billet Specialties, Velocity rims, 18×8 Rear wheels: Billet Specialties Velocity rims 20×10 Front tires: Cooper ZEON RS3 245/40-ZR18 Rear tires: Cooper Zeon RS3 265/45-ZR20 Gas tank: 18-gallons, hand fabricated
DRIVETRAIN Engine: GM LS3 crate motor (376 ci Heads: Factory Valve covers: Painted with Studebaker logo Manifold / Induction: Factory EFI Ignition: Factory Headers: Doug Thorley stainless steel Exhaust / Mufflers: Dual Flowmasters. Transmission: 4L85E four-speed automatic Shifter: Lokar tall shifter
BODY Style: 1948 Studebaker M5 Modifications: Mostly original Fenders front / rear: 2-inch wider fiberglass Hood: Steel Grille: Painted to match Bed: Curly maple planks separated by stainless steel strips, Studebaker logo on the tailgate Bodywork and paint by: S&W Collision in Georgetown, IN Paint type / Color: Custom-mixed shade of “DeMerritt” Red Headlights / Taillights: Halogen headlights, LED taillights Outside mirrors: Custom fabricated by owner Bumpers: Chrome front with classic bumper guard, none in the rear
INTERIOR Dashboard: Painted to match the exterior Gauges: Dakota Digital in the original gauge housing Air conditioning: Vintage Air Stereo: Alpine with speakers in the kick panels and behind the seat Steering wheel: Flaming River Steering column: Flaming River, adjustable, stainless steel Seats: Repurposed bench seat with center armrest and mini console. Upholstery by: Ace Rod Shop in Fairfield, IL Material / Color: dark brown and beige leather Carpet: Dark brown loop pile
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