#autotoxicity

[kerryweaverlesbian]

Autonomy

Automation,

Augmentation 

Automation,

Depersonalization 

Autocratic,

Aughta do something 

Automobile -

Got a crack 

Autogenesis,

Autoexodus,

Autoleviticus, -numbers, -song.

Listen: 

Aw, of adorable undoes

Awe, of divine.

Listen: 

All that I owned is now somehow not mine. 

Automimic.

Autotoxic.

Autocheckpoint.

Autoload.

Outta left field comes a breakthrough,

Comes a freedom,

Comes a road.

For @spnpoetryrenaissance day 2, Autonomy/Free Will.

[evoldir]

Fwd: Graduate position: UStrasbourg.EvolutionOfPlantMetabolism

Begin forwarded message: > From: evoldir@evol.biology.mcmaster.ca > Subject: Graduate position: UStrasbourg.EvolutionOfPlantMetabolism > Date: 1 December 2023 at 05:41:54 GMT > To: rdmpage@gmail.com > > > > Tag: UStrasbourg_EvolutionOfPlantMetabolism > > Fully funded PhD position available at the IBMP CNRS/University of > Strasbourg to explore the role of defense autotoxicity protection for > plant metabolism evolution > > Project description: Manipulating plant specialized metabolite (PSM) > pathways can lead to the accumulation of toxic intermediates, indicating > that in addition to defensive function selection, autotoxicity avoidance > act as a key constrain in the evolution of PSMs. However, the extent > to which autotoxicity protection mechanisms co-evolve with defensive > functions and shape plant chemodiversity dynamics remains largely > unexplored. The successful candidate will integrate the recently funded > ANR-DFG EVOMET that will employ a state-of-the-art multiomics approach > to understand the evolution of PSMs in the Solanaceae. This project > involves the establishment of metabolomics-transcriptomics atlases as > well as case-studies to decipher how autoxicity avoidance and defense > deployment are balanced. The doctoral student will notably be in charge > of metabolomics and functional analyses and will benefit from the strong > synergy established with the group of Prof. Dr. Shuqing Xu (University > of Mainz, https://ift.tt/aSnHsxo), partner of the EVOMET project. > For more details on our recent research on the topic, please see the > following publications: Elser et al. (2022) (10.1126/sciadv.ade8984), > Heiling et al. 2021 (10.1093/plcell/koab048), Li et al. (2020) > (10.1126/sciadv.aaz03) > > Requirements: We seek a highly motivated PhD student with a Master degree > in plant evolutionary biology/biochemistry with experience in some of the > following fields: evolutionary biology, metabolite analysis and RNAseq > analysis. Interdisciplinary research interests, excellent communication > skills as well as proficiency in spoken and written English are expected. > > We offer a vibrant research environment that includes access to > state-of-the art research facilities (MS metabolomics, NGS bioinformatics, > MS imaging, …), an exciting interdisciplinary research project > and a dedicated training in emerging techniques in metabolomics and > multiomics. The work will be carried out at the Institut de Biologie > Moléculaire des Plantes (IBMP, www.ibmp.cnrs.fr), the largest CNRS > institute dedicated to plant biology research. The institute is located > in the vibrant city of Strasbourg, at walking distance of the historical > center. > > The successful candidate will start on Feb / March 2024. The salary will > initially be provided for three years. > > How to apply: Applications must include a motivation > letter, a CV, contacts of 1-2 previous mentors and be sent at: > https://ift.tt/hmJylik > Please e-mail enquiries about the project to > emmanuel.gaquerel@ibmp-cnrs.unistra.fr. > > > Emmanuel Gaquerel > Professor > Institute of Plant Molecular Biology (IBMP) |Evolution and Diversity of > Plant Metabolism > CNRS | University of Strasbourg > 12 rue du Général Zimmer 67084Strasbourg,France > emmanuel.gaquerel@ibmp-cnrs.unistra.fr|+33 (0)3 67 15 53 52 > http://www.ibmp.cnrs.fr > > > "emmanuel.gaquerel@ibmp-cnrs.unistra.fr"

[opensky-tom]

A life stores wonderful treasures full of wonder within itself!

[sciencespies]

How plants produce defensive toxins without harming themselves

https://sciencespies.com/nature/how-plants-produce-defensive-toxins-without-harming-themselves/

How plants produce defensive toxins without harming themselves

Plants produce toxic substances to defend themselves against herbivores. In a new study, scientists from the Max Planck Institute for Chemical Ecology in Jena and the University of Münster, Germany, were able to describe in detail the biosynthesis and exact mode of action of an important group of defensive substances, the diterpene glycosides, in wild tobacco plants. Diterpene glycosides allow plants to fend off herbivores. The study shows that these plant chemicals attack certain parts of the cell membrane. To protect themselves from their own toxins and to prevent their cell membranes from being damaged, tobacco plants store these substances in a non-toxic form, which is synthesized in a very particular way. Autotoxicity and the protection against it seem to play a greater role in the evolution of plant defenses than previously thought.

Many plants produce chemical defenses to protect themselves against being eaten. Still little is known about what makes these substances toxic to their consumers. Researchers at the Max Planck Institute for Chemical Ecology and the University of Münster have now investigated how plants produce toxins and store them in their tissues without harming themselves. In particular, they wanted to know whether the mechanisms of autotoxicity and its prevention share similar mechanisms as the toxic characteristics that provide defense against herbivores.

Autotoxicity and defense

For their experiments, they chose diterpene glycosides from Nicotiana attenuata plants, a wild tobacco species. “These substances occur at very high concentrations in the leaves of tobacco plants. But we had no idea why they were such effective defenses or why they could be so toxic to produce. So the situation was completely different from the other very abundant toxin that this plant produces, namely, nicotine. Nicotine is a specific neurotoxin. Since plants lack nerves and muscles, they offer no target for the toxin. So producing and storing nicotine does not harm plants,” says Ian Baldwin from the Department of Molecular Ecology at the Jena Max Planck Institute, where the study was carried out.

To their surprise, the researchers found that tobacco plants which had been transformed so they could no longer produced two proteins involved in the biosynthesis of the diterpene glycosides and thus also not form the defensive substances otherwise stored in the leaves in large amounts, showed conspicuous symptoms of self-poisoning: they were sick, unable to grow normally, and could no longer reproduce. Further experiments revealed that certain components of the cell membrane, so-called sphingolipids, had been attacked.

Targeting the cell membrane

Sphingolipids are substances found in all animals and plants, including the enemies of wild tobacco, the larvae of the tobacco hawkmoth Manduca sexta. The researchers therefore asked whether the sphingolipid metabolism could be the target of the diterpene glycosides. In fact, Manduca sexta caterpillars, which had fed on plants without diterpene glycosides, grew significantly better than larvae, which had fed on controls that contained the defensive chemicals. Analyses of the frass of Manduca sexta larvae, which had ingested diterpene glycosides with their food, provided further insights, as the degradation of the plant toxins during larval digestion is more or less in reverse order to the synthesis of the substances in the plant. Plants prevent self-harm by storing the defensive substances in a non-toxic form. However, when insects feed on the plant, a part of the non-toxic molecule is cleaved off and the chemical becomes activated or “armed.” “Interestingly, in both cases, in plants with incomplete diterpene glycoside biosynthesis and in feeding caterpillars, the target of the toxins is the sphingolipid metabolism,” says first author Jiancai Li.

Sphingolipids are mediators in many physiological processes. This makes the effect of diterpene glycosides on sphingolipid metabolism so intriguing. “Diterpene glycosides and their derivatives can have broad defensive functions against many agricultural pests and pathogenic fungi. At the same time, many human diseases, such as diabetes, cancers and some neurodegenerative diseases are also associated with elevated sphingolipid metabolisms,” says Shuqing Xu from the Institute for Evolution and Biodiversity at the University of Münster, who is one of the senior authors of the study. Physicians have been searching for effective substances to treat these diseases by inhibiting the sphingolipid metabolism. The diterpene glycosides studied here could be potential candidates for further investigations.

“Frassomics” — a new powerful tool to study interactions between organisms

The analysis of larval frass proved to be the key to success in this study. The scientists call this new approach “frassomics”: a combination of frass (larval droppings) and metabolomics — the analysis of all metabolites in an organism. “From this work, we realized that frassomics can be a very powerful research tool. The analysis of larval frass can provide metabolic clues about how what one organism produces is metabolized by consumer organisms,” says Ian Baldwin.

The scientists plan to gain more insights into the “digestive duets” that occur between plants and insects, in order to better understand ecological interactions between plants, insects and microorganisms.

#Nature

[symptomszone]

What are the causes of bad breath?

Bad breath severely affects people's interpersonal communication, bad breath may be a sign of a certain disease, so people with bad breath must be treated in time. So what exactly is bad breath? What are the treatments for bad breath? Let ’s get to know it together!

Causes of bad breath

I. Oral diseases: People who have dental diseases such as tonsillitis, dental caries, gingivitis, periodontitis, oral mucositis, and tooth decay, periodontal disease, etc., are prone to breed bacteria, especially anaerobic bacteria, which decomposes to produce sulfur. The material emits a rotten smell and produces bad breath.

Second, gastrointestinal diseases, such as peptic ulcer, chronic gastritis, functional dyspepsia, etc., may be accompanied by bad breath. Recently, we have also found that the incidence of halitosis in people. After the eradication of H. pylori, the symptoms of halitosis are significantly reduced. The cause may be that H. pylori infection directly produces sulfide and causes bad breath.

Third, people who smoke, drink alcohol, drink coffee, and often eat onions, garlic, chives and other spicy stimulating foods, or people who like stinky tofu, stinky eggs and other odorous foods are also prone to bad breath.

The fourth is  Diet and weight loss, or inability to eat due to illness, or decreased salivary gland function in the elderly, and women's endocrine disorders during menstruation leading to reduced salivary secretion, which is conducive to the growth of anaerobic bacteria, so bad breath occurs.

Fifth, Gender: Some women in adolescent development, ovarian insufficiency, lower sex hormone levels, oral tissue resistance decreases, easily infected with bacteria and produce bad breath.

Sixth. Drugs that can reduce saliva secretion, such as certain sedatives, antihypertensive drugs, atropine drugs, diuretics, and traditional Chinese medicines with warming effect.

Seventh. Patients with diabetic ketoacidosis, liver coma, and some respiratory diseases such as bronchitis, bronchiectasis, sinusitis, laryngitis, tonsillitis, and pulmonary cysts may also cause bad breath.

Eighth. Long-term constipation can cause bad breath and bloating, loss of appetite, irritability and other autotoxic symptoms such as the harmful substances produced in the body cannot be excreted in time and absorbed into the blood.

Nine, Diet is too "heavy", eat large amount or eat meat, greasy food or the amount of hot irritating seasoning.

10. Excessive psychological pressure, frequent mental stress causes the parasympathetic nerves of the body to be in an excited state, and the digestive glands, especially the salivary glands, are reduced in reflection, leading to dry mouth, which is conducive to the growth of anaerobic bacteria and produces bad breath.

[marisdoner]

Colon Function In Digestive System

No need for the flu shot use The Hydrogen Peroxide Ear Treatment

Colon Function In Digestive System https://www.anoasisofhealing.com/ Let’s review the colon function in our digestive system The large intestine or colon performs the end stages of digestion. What this means is the colon function in the digestive system is responsible for elimination. It ushers waste out of the human body via the colon. There are two types of intestines. The small and large intestines. The stomach connects to the small intestines. The mid part of the digestion process happens in the small intestines before it enters the large intestine or our colon. One of the key functions of the large intestines is for the water to be reabsorbed. This process takes 6 hours for the gastric juices and partly digested food to travel from the small intestines to the colon. What should happen with a properly functioning colon is 6 to 7 hours after eating, you should eliminate all that had eaten earlier. Unfortunately, for most of us, this doesn’t happen. What does happen is people accumulate feces which allows it to putrefy and ferment. The poisons and toxins produced as a result of this then get absorbed into the liver and now hepatotoxicity and autotoxicity exists. Before healing can occur all poisons and toxins must be eliminated. Everything we consume ends up going to the liver. The accumulation of waste that stays in the colon will be recycled to the liver. If the colon isn’t kept clean, the liver ends up working overtime all the time and this isn’t healthy. If someone is only going to the bathroom once a day that is not enough. The colon is big and eliminating only once per day equates to waste accumulation. At An Oasis of Healing, we use colon hydrotherapy as a foundational part of our adjunct therapies. This therapy helps with the elimination of toxins and poisons from the body. Hydrotherapy is part of our comprehensive cancer care program. Contact us today and learn how we can help! https://www.youtube.com/playlist?list=PLgEvpazxx5NPjEEZY910Vd7Hvp-KVAXK2 https://www.youtube.com/channel/UCR0Y7icMoXgQZaepRkJlHzg/videos [Read More ...]

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Colon Function In Digestive System was originally posted by Health Nutrition And Strange Science News

[lieutolu-blog]

PH do corpo, o que deveria ser?

Em 1933, Dr. William Howard Hay de Nova York publicou o livro inovador "Uma Nova Era na Saúde" no qual argumentava que a causa de todas as doenças é autotoxication (autotoxication) ou seja, o acúmulo de ácidos no corpo:  "Hoje nós afastar a saúde exatamente proporcional à redução alcalino devido ao consumo de ácido formando alimentos em demais ... para dizer isto pode parecer estranho que a causa de todas as doenças é a mesma, não importa o que são os inúmeros tipos de nomes, mas no final de k aishta isto é confirmado. "- Dr. William Howard Hay (Howard Hay, MD). Recentemente, em seu notável livro" alkalized or Die "(Alkalize or Die, Dr. Theodore A. Baroody), Dr. Theodore A. Baroodi diz essencialmente a mesma coisa: "Os inúmeros nomes de doenças são irrelevantes. É importante que todos eles venham da mesma causa ... excesso de resíduos ácidos nos tecidos do corpo. " - Dr. Theodor A. Barroodi. A população de bactérias boas (amigáveis) no intestino está relacionada ao pH do corpo. O excesso de acidez, que é muito comum hoje, pode se transformar em uma condição perigosa que enfraquece os vários sistemas do corpo. Isso leva a um ambiente favorável à doença, ao contrário de um ambiente de pH balanceado que permite o funcionamento normal dos sistemas do organismo, condição necessária para resistir ao organismo da doença. O órgão de saúde mantém reservas alcalinas adequadas para atender a solicitações urgentes. Quando o excesso de ácidos precisa ser neutralizado, as reservas alcalinas são exauridas, deixando o corpo em uma condição enfraquecida. A dieta equilibrada, segundo muitos especialistas, é vital e essencial para uma boa saúde. O conceito de desequilíbrio de ácido alcalino como causa de doença não é novo. O pH desequilibrado do corpo cria um ambiente ácido que faz com que o corpo tome minerais, incluindo cálcio, sódio, potássio e magnésio de órgãos vitais e ossos, para tamponar (neutralizar) os ácidos e removê-los com segurança do corpo. Por causa da compressão dos minerais do corpo, pode sofrer severa e prolongadamente os danos causados ​​pela alta acidez (produtos metabólicos ácidos), uma condição que pode passar despercebida durante anos.   A acidose leve pode causar problemas como: Danos cardiovasculares, incluindo contração dos vasos sanguíneos e depleção de oxigênio.   Ganho de peso, obesidade e diabetes. Problemas na bexiga e nos rins, incluindo pedras nos rins. Imune deficiência.   Aceleração do dano pelos radicais livres, possivelmente contribuindo para mutações do câncer. Problemas hormonais.   Envelhecimento precoce.   Osteoporose; fracos, ossos frágeis, fraturas femorais e formação óssea. Dor nas articulações, dor muscular e acúmulo de ácido láctico.   Escassez de energia e fadiga crônica.   Má digestão e eliminação.   Infecção Fúngica (Yest Infection, Yeast Infection) / Crescimento excessivo de Candida albicans (Candida fungo). http://www.a-better-way.com/naturalhealthschool/acid-alkaline.html PH ou Pe Ha do nosso organismo é muito importante estar dentro dos limites normais. O pH é a razão de íons carregados positivamente (ácido) e íons carregados negativamente (alcalino). Quando o pH é 7,0 o nosso organismo é neutro, nem ácido nem alcalino. Se o pH é 6,0, é ácido. Este ambiente é pobre em oxigênio. O que está acontecendo no ambiente ácido? Este é um ambiente em que você vive com calma bactérias nocivas, microorganismos nocivos, bactérias Candida e bactérias infecciosas purulentas e vírus, é claro. Nós tendemos a ficar doentes das doenças mais inofensivas para as mais sérias. Em ambientes alcalinos, esses bacilos não podem viver. A comida que comemos e a água que bebemos determina o ambiente em nosso corpo. Diferentes tipos de vegetais e frutas diferem, e alguns, por exemplo, como um limão que é ácido quando usado, ajudam a alcalinizar o meio. Então, se somos rábano ou vegetariano, dados os fertilizantes químicos que fertilizam o solo, é bom saber qual é o nosso pH. É medido com tiras de pH na urina no início da manhã. Ácido do corpo é jogado na urina. Meça o seu pH regularmente. A propósito, o humor verde ajuda a alcalinizar o ambiente. As pessoas que são cancerígenas, úlceras, gastrite e outras, as bactérias Candida, vírus que estão frequentemente doentes com gripe e resfriados que se queixam de fadiga constante, muitas vezes têm um ambiente ácido. As células saudáveis ​​normais são alcalinas e as células cancerígenas são ácidas. Muitos estudos mostraram que o câncer, Células cancerosas não podem sobreviver em um ambiente alcalino rico em oxigênio.A pH 7,4, as células cancerígenas são letárgicas e a um pH de 8,5 para cima, as células cancerígenas morrem. Quando o corpo é ácido, também pode tender a gastrite, úlcera, diarréia e / ou constipação, problemas de pele, artrite e outros. Ambiente muito alcalino durante um longo período de tempo também pode causar problemas, como fraqueza e desidratação muito grave do corpo. Na maioria das vezes, nosso corpo deve ter um ambiente levemente alcalino ou quase alcalino. É muito importante que o organismo mude para um ambiente fracamente ácido para que o sistema imunológico funcione bem. Isso limpa, elimina as bactérias nocivas e as células cancerígenas, satura drasticamente o corpo com água, o que ajuda a eliminar toxinas para lidar com várias ameaças, e assim por diante. e então o corpo retorna novamente a um ambiente alcalino. O sangue deve ser ligeiramente alcalino 7.35-7.45. Se a comida que ingerimos cria um ambiente corporal ácido, ela também afeta o sangue e o corpo tenta equilibrar o pH. Quando isso é um problema, diferentes minerais são tomados por muitos órgãos importantes para neutralizar a azia e se livrar do corpo. Este corpo está começando a sofrer, e isso muitas vezes não é visto há anos e muitas vezes leva a doenças graves. Se o pH da urina estiver entre 6,0-6,5 manhã cedo e 6,5-7,0 à noite antes do jantar, o nosso corpo está em uma condição relativamente boa. O teste de pH da urina mostra como nosso corpo é liberado dos ácidos e como ele assimila os minerais benéficos, como cálcio, magnésio, potássio e sódio. Estes minerais atuam como tampões que mantêm o equilíbrio do pH do corpo. Se a nossa acidez é muito alta por um longo tempo, só devemos comer vegetais, frutas, beber água mineral e abrir mão de pão branco, carne vermelha, bebidas carbonatadas, chá preto, café, álcool e açúcar. Medicamentos criam um ambiente fortemente ácido. Para restaurar a saúde, precisamos tomar 80% de alimentos alcalinos e 20% de alimentos formadores de ácido. A mudança abrupta da dieta é como um choque para o trato gastrointestinal, que pode causar inflamação e também sangue nas fezes. Portanto, a mudança para alimentos alcalinos deve ser gradual, a fim de evitar uma forte reação do corpo. A dieta pode durar de duas semanas a um mês. Uma vez que tenhamos restaurado o ambiente corporal normal, podemos voltar a uma dieta balanceada com uma variedade de alimentos de ambos os grupos de alimentos, alcalinos e ácidos.

[aanlaiias-s]

the numbing faux pas, an evil

announcement: past styles of composing a style of being in some sorts of “experiment” embarrass me. sorry for the self-absorption and more importantly sorry for not ever giving anybody refuge 

more than that, really, sorry for being so violently ignorant and obnoxious and enforcing civilities I now find repellent, and discover new repulsions to everyday. there is no discrete moment of making oneself act right. if I could I would have had a more delicate adolescence. instead I cycled through the basic package of replicas, plumes of autotoxicity that indulge in the remote findings of other people/s: for simplicity let’s call it appropriative ways of thinking, speaking, and feeling I can only try to dismantle as I go on, literally and in the figures I dip into, so as to not just shudder at but transform the senses in the cold light of the damage those compositions reinforce and all the nothing they do for anyone except people like me -- the ploy for a cultural capital reckless enough to indifferently rob people of the lives they actually have to live through, joyously and with the bitterest loss and other feelings besides (including that of not having to do anything), which aren’t mine, much less for effect. 

not that, pristine or reformed, I know so much better now... and the last thing I want from my unsolicited advice to my past is any sort of claim on addressee, the first prerequisite for apologizing. other impulses are there too and I’ll try to find the silvery ones

[knomrlse]

SWIPE FOR MORE INFO According to Dr. John Harvey Kellogg, “90% of the diseases of civilization are due to improper function of the colon.” While this could be an overstatement, possessing a normal functioning digestive system that enables proper nutritional assimilation and waste removal is critically important for good health. All in all, the autotoxicity that results from a colon filled with toxic waste products contributes to a whole host of long-term chronic illnesses and can be prevented by simple cleanliness measures. With that said, learn how to cleanse your colon in order to experience a better quality of life and avoid being bombarded by a toxic overload. There are a number of diseases that don’t appear to be related to the colon on a first glance, however, they are a direct result of colon toxicity. Aside from the most obvious purpose of the colon, fecal matter dehydration and removal, it has a number of other biological functions as well. This includes reabsorbing electrolytes and water into the body in order to use them as needed. A healthy colon also facilitates the removal of heavy metals and other toxins that are introduced into the body, allowing the body to remove its toxic load with ease. The colon is home to a myriad of bacteria. Since 60 to 70% of immune system function is attributed to healthy bacteria concentrations in the colon, a clean, eliminative organ is necessary for optimal health. A functional colon that is clean, has a balance of healthy bacteria, is free of pathogenic mycelial candida and parasites promotes general good health. Those who are looking for a better quality of life should look no further than the cleanliness of their colon. In order to cleanse your colon, eating right and living well are a necessary first step. #colon #gut #guthealth #healthygut - #regrann

[taoyuanled]

Cytec ADDITOL pionees new areas of UV curing

According to the Chinese Academy of Agricultural Sciences Institute of Agricultural Environment and Sustainable Development researcher Liu Wenke introduction, closed soilless cultivation easily lead to accumulation of autotoxic substances, and TiO2 photocatalytic degradation of the substrate culture nutrient solution in the root exudates and rice husk degradation Product, the sun only contains 3% of the UV curing lamp light, the facilities cover the material such as glass filter out more than 60%, can not be used in the facilities; vegetable seasonally cultivated winter low temperature and low exposure to the low efficiency and poor stability, unable to meet the facilities vegetable factory The need for production. Countries around the world are actively studying the feasibility of using UV LED as a tissue source. In the study of the effect of monochromatic light on tissue culture, red light UV LEDs could promote leaf growth of orchid tissue culture seedlings, but chlorophyll content, stem and root dry weight were slightly lower than fluorescent lamps. By using UV LED to supplement monochromatic red or far red light to change the light quality, and then control the length and growth of potato tissue culture stems. The results showed that the elongation of stem was weak and other important indexes were also reduced, which was not conducive to the normal growth and development of plants. The main reason is that monochromatic red light leads to the unbalanced distribution of light energy available to the system, which inhibits the growth of stem. The results showed that the plant height and internode length of all genotypes were significantly longer than those of the fluorescent lamp, UVC LED but the chlorophyll content and the number of leaf stomata were the highest in the monochromatic blue light UVLED treatment. UVLED treatment is the lowest. This indicates that plant height is directly related to the proportion of rooting, and long red light is necessary for the formation of grape root.