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hostalsantaclaraestartit · 2 years ago

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#ana cristina mazariegos #ana cristina mazariegos aragón #anna cristina mazariegos #anna cristina mazariegos aragón #advocats #advocada #abogada #abogados #torroella #de montgrí #Youtube

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mariebenz · 6 years ago

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Sentinel Lymph Node Drainage Can Be Used to Test For Marker of Melanoma Relapse Risk

MedicalResearch.com Interview with:

Dr. Peinado Héctor Peinado PhD Microenvironment and Metastasis Laboratory Molecular Oncology Program Spanish National Cancer Research Center Madrid, Spain MedicalResearch.com: What is the background for this study? What are the main findings? Response: In this study we detected for the first time BRAF mutation by liquid biopsy in melanoma stage III patients that underwent lymphadenectomy. We obtained a novel biofluid from the drainage implanted 24-48 hours post-lymphadenectomy, called exudative seroma, and profiled BRAF mutation in circulating free DNA and extracellular vesicles. Those patients positive for BRAF mutation in the seroma had increased risk of relapse, therefore we believe that this technique identifies patients at risk of relapse by identifying residual disease. MedicalResearch.com: What should readers take away from your report? Response: I would explore any material obtained post-surgery as means of residual disease so we can develop further test to improve prognosis. MedicalResearch.com: What recommendations do you have for future research as a result of this work? Response: This test was performed in melanoma patients, but could be applicable to any tumor type where lymphadenectomy of sentinel lymph node drainage is implanted. We are also developing test for plasma. Citation: Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAFV600E mutation Susana García-Silva, Alberto Benito-Martín, Sara Sánchez-Redondo, Alberto Hernández-Barranco, Pilar Ximénez-Embún, Laura Nogués, Marina S. Mazariegos, Kay Brinkmann, AnaAmor López, Lisa Meyer, Carlos Rodríguez, Carmen García-Martín, Jasminka Boskovic, RocíoLetón, Cristina Montero, Mercedes Robledo, Anna Szumera-Ciećkiewicz, Iwona Kalinowska, Johan Skog, Mikkel Noerholm, Javier Muñoz, Pablo L. Ortiz-Romero, Yolanda Ruano, José L.Rodríguez-Peralto, Piotr Rutkowski, Héctor Peinado Journal of Experimental Medicine Apr 2019, jem.20181522; DOI: 10.1084/jem.20181522 http://jem.rupress.org/content/early/2019/04/10/jem.20181522.abstract The information on MedicalResearch.com is provided for educational purposes only, and is in no way intended to diagnose, cure, or treat any medical or other condition. Always seek the advice of your physician or other qualified health and ask your doctor any questions you may have regarding a medical condition. In addition to all other limitations and disclaimers in this agreement, service provider and its third party providers disclaim any liability or loss in connection with the content provided on this website. Read the full article

#Biomarkers #cancer #cancerresearch #JExpMed #lymphnode #melanoma

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hostalsantaclaraestartit · 2 years ago

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