#Ultima Pharmaceuticals – US
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Exploring the Frontier: The Global DNA Methylation Detection Technology Market
DNA methylation detection technology stands out as a crucial tool for understanding gene regulation, epigenetics, and disease mechanisms. With advancements in genomics and epigenetics, the global DNA methylation detection technology market has been witnessing remarkable growth, driven by the increasing demand for personalized medicine, precision oncology, and epigenetic research.
The global DNA methylation detection technology market is projected to experience substantial growth over the forecast period 2023-2033. Moreover, the market value for 2023 was $2.80 billion, which is expected to reach $12.32 billion by 2023, growing at a CAGR of 15.96%
DNA Methylation Detection Technology Overview
DNA methylation is an epigenetic mechanism that involves the addition of a methyl group to the DNA molecule, typically at cytosine bases within CpG dinucleotides. This modification plays a pivotal role in regulating gene expression, genomic stability, and cellular differentiation.
Market Segmentation
Segmentation 1: by Product
Segmentation 2: by Technology
Segmentation 3: by Application
Segmentation 4: by End User
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Epigenetic Market
The field of epigenetics, which focuses on changes in gene expression that do not involve alterations to the DNA sequence itself, has gained significant attention in recent years for its potential in understanding and treating various diseases.
Various factors involved are market growth, technological advancements, therapeutic potential
The Epigenetic Market Report forecasts continued expansion of the epigenetic market, fueled by ongoing research advancements, increasing investment in biotechnology and pharmaceutical sectors, and growing adoption of epigenetic-based diagnostics and therapeutics.
Deoxyribonucleic Acid (DNA) methylation market
With advancements in next-generation sequencing (NGS) technologies and bioinformatics tools, DNA methylation analysis has become more accessible and cost-effective. The report delves into the latest technological innovations driving market growth, such as whole-genome bisulfite sequencing (WGBS), reduced representation bisulfite sequencing (RRBS), and methylation-specific PCR (MSP).
DNA methylation biomarkers hold immense potential for early disease detection, prognosis, and treatment response prediction across various medical disciplines. The report explores the burgeoning interest in using DNA methylation signatures for cancer diagnosis and monitoring, neurological disorders, cardiovascular diseases, and other pathologies.
Recent Developments in the Global DNA Methylation Detection Technology Market
Pacific Biosciences of California, Inc., and GeneDx initiated a research collaboration with the University of Washington. This partnership focuses on studying the effectiveness of long-read whole genome sequencing in improving diagnostic accuracy in neonatal care. Ultima Genomics, Inc. announced a partnership with New England Biolabs to integrate NEB's NEBNext reagents and library preparation kits into Ultima's sequencing platforms. This collaboration would develop and optimize next-generation sequencing (NGS) processes for DNA, RNA, and methylation sequencing applications.
Key Players
Agilent Technologies, Inc.
Abcam plc.
Bio-Rad Laboratories, Inc.
Illumina, Inc.
QIAGEN N.V.
Thermo Fisher Scientific, Inc.
And many others
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Key Questions Answered
▪ What is the estimated global market size for the global DNA methylation detection technology market?
▪ Who are the key players in the global DNA methylation detection technology market?
▪ What are the different types of products available in the global DNA methylation detection technology market?
▪ Which region holds the largest market share in the global DNA methylation detection technology market?
▪ How has the COVID-19 outbreak affected the future trajectory of the global DNA methylation detection technology market?
Conclusion:
The global DNA methylation detection technology market holds immense potential for driving advancements in basic research, clinical diagnostics, and personalized medicine. With ongoing technological innovations, expanding applications, and growing investments in epigenetics research, this market is poised for continued growth and innovation, contributing to our understanding of human health and disease at the molecular level.
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Saxenda Australia: A Cost-Effective Solution for Weight Loss
Saxenda Australia: A Cost-Effective Solution for Weight Loss
In recent years, the demand for effective weight loss solutions has been on the rise in Australia. Saxenda, also known as Liraglutide, has emerged as a popular choice among individuals struggling with obesity. This article aims to shed light on Saxenda in Australia, its benefits for weight loss, and provide insights into the cost-effectiveness of this medication in Australian pharmacies.
PhenQ contains natural ingredients like capsicum, piperine, caffeine, and niacinamide, that work together to boost metabolism, suppress appetite,
Understanding Saxenda:
Saxenda is a prescription medication that contains the active ingredient Liraglutide. Originally developed to treat type 2 diabetes, it has gained recognition as an effective aid for weight loss. Saxenda works by mimicking a hormone called GLP-1 (glucagon-like peptide-1), which helps regulate appetite, food intake, and blood sugar levels.
The Benefits of Saxenda for Weight Loss:
Appetite Suppression: Saxenda acts on the appetite centers in the brain, reducing feelings of hunger and promoting a sense of fullness. This can help individuals control their caloric intake and make healthier food choices.
Weight Loss Aid: Clinical trials have demonstrated that Saxenda can lead to significant weight loss when combined with a reduced-calorie diet and regular physical activity. It is particularly effective for individuals with a body mass index (BMI) of 30 or higher, or those with a BMI of 27 or higher and obesity-related comorbidities.
Sustained Results: Saxenda helps individuals maintain their weight loss over the long term. Studies have shown that continued use of Saxenda beyond one year can lead to additional weight loss and help prevent weight regain.
The Cost of Saxenda in Australian Pharmacies:
The cost of Saxenda in Australian pharmacies can vary depending on several factors, including the pharmacy's location, the dosage prescribed, and any applicable discounts or insurance coverage. While Saxenda is not available over the counter, it is covered by the Pharmaceutical Benefits Scheme (PBS) for eligible patients. This means that individuals who meet specific criteria can access Saxenda at a subsidized cost.
It is recommended that individuals consult their healthcare provider to determine their eligibility for subsidized Saxenda under the PBS. Additionally, various pharmacies may offer competitive pricing or discounts on Saxenda, so it is advisable to compare prices before making a purchase.
Cheaper Alternatives and Cost-Effectiveness:
While Saxenda is a popular choice for weight loss, it is worth exploring other cost-effective alternatives as well. Generic versions of Liraglutide may be available at a lower cost, providing a more affordable option for individuals seeking similar benefits. However, it is essential to consult with a healthcare professional to ensure the safety and efficacy of generic alternatives.
In addition to medication, it is important to consider other cost-effective strategies for weight loss, such as adopting a healthy diet, increasing physical activity, and seeking support from healthcare professionals or weight loss programs. These approaches can complement the use of Saxenda or generic alternatives, contributing to sustainable weight loss and overall well-being.
PhenQ contains natural ingredients like capsicum, piperine, caffeine, and niacinamide, that work together to boost metabolism, suppress appetite,
Conclusion:
Saxenda (Liraglutide) has emerged as an effective weight loss solution in Australia. Its ability to suppress appetite, aid weight loss, and promote long-term weight maintenance makes it an attractive option for individuals struggling with obesity. While the cost of Saxenda can vary in Australian pharmacies, exploring generic alternatives and leveraging available subsidies can help make this medication more affordable. Ultimately, combining Saxenda with lifestyle modifications can lead to effective and sustainable weight loss results. Remember to consult with a healthcare professional to determine the best approach for your weight loss journey.
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AI in Genomics Market: Meticulous Research Reveals Why This Market is Growing at a CAGR of 52.4% to Reach $12.15 Billion by 2029
Artificial intelligence (AI) plays an important role in genomics. Integration of AI in genomics increases the interpretability of genomic data and improves disease diagnosis. AI in genomics helps understand genetic change and variations. It also helps identify, diagnose genetic diseases, and detect changes in the genetic material. In its latest publication on AI in genomics, Meticulous Research® states that the global AI in genomics market is slated to register a CAGR of 52.4% during the forecast period 2022–2029 to reach $12.15 Billion by 2029.
To provide efficient analysis, Meticulous Research® has segmented the global AI in genomics market by offering (software, services), delivery mode (on-premises, cloud-based/web-based), functionality (genome sequencing, gene editing, other functionalities), application (drug discovery and development, precision medicine, diagnostics, and other applications), end user (pharmaceutical & biopharmaceutical companies, research institutes & academics, and other end users), and geography.
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Based on geography, in 2022, North America is estimated to account for the largest share of the global AI in genomics market, followed by Europe. The largest market share of North America is mainly attributed to the high adoption of AI solutions in precision medicine, increased focus on controlling drug development and discovery costs, and growing government initiatives and research funding for precision medicine. Initiatives taken by key market players such as Microsoft Corporation (U.S.), NVIDIA Corporation (U.S.), Deep Genomics (Canada), and Fabric Genomics, Inc. (U.S.) help drive the AI in genomics market. For instance, In June 2022, NVIDIA Corporation (U.S.) collaborated with Ultima Genomics, Inc. (U.S.) to leverage AI-based analysis across multiple phases of DNA sequencing and analysis.
Based on offering, in 2022, the software segment is estimated to account for the largest share of the global AI in genomics market. The growing use of AI in genomics software in pharmaceutical & biopharmaceutical companies for drug development and discovery increases the demand for AI genomics software. AI in genomics software helps identify information from genomic datasets effectively and in less time, accelerating genomics research. Increasing R&D based on drug discovery and development drives the demand for AI in genomics software.
Based on delivery mode, the market is segmented into cloud-based/web-based and on-premises. The cloud-based segment is expected to register the highest CAGR during the forecast period. The ability of the cloud-based web-based model to store a huge amount of genomic data, high security, and easy remote access are the key factors contributing to the market growth.
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Based on functionality, in 2022, the genome sequencing segment is estimated to account for the largest share of the global AI in genomics market. The large market share of this segment is attributed to factors such as growing and developing research activities in genomics to understand genetic changes and gene-related diseases.
Based on application, the market is segmented into drug discovery and development, precision medicine, diagnostics, and other applications. In 2022, the drug discovery and development segment is estimated to account for the largest share of the global AI in genomics market. The large market share of this segment is attributed to key factors such as the high adoption of AI in genomics offerings due to the rising need to identify the drug molecule in less time. During the COVID-19 pandemic, the need for urgent drug discovery and development further increased the adoption of AI in genomics for drug discovery and development.
In terms of end user, in 2022, the pharmaceutical & biopharmaceutical companies segment is estimated to account for the largest share of the global AI in genomics market. The large market share of this segment is attributed to the increasing use of AI in genomics offerings in pharmaceutical & biopharmaceutical companies for drug discovery and precision medicine and rising innovation in drug discovery and development.
Key Players:
The report provides competitive intelligence in terms of financials, growth strategies, product portfolios, and geographical presence on some of the key players operating in the global AI in genomics market Microsoft Corporation (U.S.), NVIDIA Corporation (U.S.), Deep Genomics (Canada), Fabric Genomics, Inc. (U.S.), Data4Cure, Inc. (U.S.), Predictive Oncology Inc. (U.S.), Emedgene (U.S.), Congenica Ltd. (U.K.), Tempus (U.S.), SOPHiA GENETICS (Switzerland).
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Key questions answered in the report-
Which are the high-growth market segments in terms of offering, delivery mode, functionality, application, end user, and geography?
What was the historical market for AI in genomics across the globe?
What are the market forecasts and estimates for the period 2022–2029?
What are the major drivers, restraints, opportunities, and challenges in the global AI in genomics market?
Who are the major players in the global Artificial Intelligence in genomics market?
How is the competitive landscape, and who are the market leaders in the global AI in genomics market?
What are the recent developments in the AI in genomics market?
What are the different strategies adopted by the major players in the AI in genomics market?
What are the geographic trends and high growth regions/countries?
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The woman murdered in Palma had reported episodes of harassment by her ex-partner
Five days ago he filed a complaint after several posters appeared that offered sex with his phone and found the tires of his car punctured
Sacramento Roca, the 36-year-old woman murdered this Friday by her ex-partner while working in a furniture store in Palma, filed a complaint five days ago at the National Police Headquarters in which she pointed to her ex-partner, the security guard of 45-year-old Rafael Pantoja, as the person behind the punctures on the wheels of his car and several posters hanging on the streets of the capital in which sex was offered with his phone number. ultima pharmaceuticals usa online The couple had broken the relationship at the beginning of last October, but the man had refused to accept the facts and, according to sources of the investigation, had appeared on several occasions at the Sacramento workplace to try to convince her to resume the relationship.
The murder occurred on Friday after five in the afternoon when the victim had been working in a well-known furniture store in Palm for fifteen years. His ex-partner, a well-known security guard in the capital's courts where he had worked for years, entered the establishment unseen and pounced on Sacramento from behind with a knife. He stabbed him with more than five stab wounds, some of which were fatal, to the shouts of the customers who were at the time at the checkout line of the store. Pantoja fled the scene and tried to hide in one of the nearby streets, but was chased by an off-duty local police officer and a sworn vigilante who managed to hold him until a police patrol arrived.
The victim was treated at the scene by the health services. A mobile ICU and several doctors tried to revive her for minutes, but some of the stab wounds had affected vital organs and she was unable to overcome the attack. Pantoja was detained next to the parking lot of the establishment, where the weapon used to perpetrate the crime was also found. The store remained closed throughout the afternoon and investigators were taking statements from Sacramento customers and coworkers, appalled at what happened. The security cameras of the establishment that collected the crime were also reviewed.
The couple had broken up on October 13 and since then Pantoja, a bodybuilding fan and father of two children, had appeared at the victim's workplace on several occasions to ask them to resume the relationship. Sources in the case have also explained that the security guard had called Sacramento on countless occasions to try to convince her to return together. She continued with her life, she was also the mother of two children of previous couples, until last November 12, she found the wheels of the car flat when she left work. He went to the National Police station and in the complaint pointed to his ex-partner as the person who could be behind the events.
The victim also reported that, in parallel, she had found signs on a street in the Son Oliva neighborhood and at the intermodal train station in the city offering sex and listing her phone number. Sacramento also targeted his former partner as the person he suspected to be the author of the poster. He explained to the police officers that during the relationship, which lasted for a year, he had not suffered episodes of abuse but that the man had changed his attitude after ending the relationship when he had intensified the phone calls and had begun to introduce himself at your workplace.
National Police officers continue to investigate the crime. This Saturday a statement will be taken from witnesses and family members of the victim and the murderer, who has been transferred to the Son Espases hospital after trying to self-harm himself in the cells of the Palma National Police Headquarters. He is scheduled to go to court on Monday at the Via Germany Courts, where he also worked for a few months.
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Maybe.... books? As a precure theme?
I’m going to get more specific: the theme is going to be (some of) the books I was assigned to read in high school.
The fairy mascot is a mockingbird fairy called Scout (book: To Kill a Mockingbird). She comes from the kingdom known as Bibliotecha and was a librarian in the royal library. However, when the BookBurner Gang attacked, Scout found herself taking the four Shining Bookmarks to Earth, or more specifically, to Edgar Allen Poe High School (I wasn’t required to read a book of his poetry specifically, but I did have to read a book of poetry and his was available). There, Scout finds the Shining Literary Pretty Cure, who will fight the BookBurner Gang’s Quematadors (portmanteu of quemador (Spanish word for burner) and matador (Spanish word for bullfighter)).
While transformed, the Shining Bookmarks become ribbons kept in the Cure’s hair; underneath their skirts all girls wear petticoats that resemble pages out of books, complete with tiny writing on them. All four girls end up joining the book club together.
Cure Ultima (book: Bless Me, Ultima), otherwise known as Marisol Asturias. She’s a third-generation Mexican immigrant, and she lives with her parents, maternal grandmother, and two sisters of whom she’s the middle child. She wants to be a pharmacist when she grows up, but she doesn’t like the way many pharmaceutical companies function. Naturally, she wears pink; her outfit contains elements from traditional china poblana style of dress. As the Cure of Magical Realism, she has illusionary and light based abilities.
The next cure found was Cure Earth (book: The Good Earth), otherwise known as Octavia Lan Wang. She’s a second-generation Chinese immigrant; her name is written first, middle, and then last name. She goes by Lan among her family and Octavia at school. She has a small vegetable garden that she tends to, and sometimes she’ll bring snacks involving vegetables she’s grown. She wears yellow, and her costume contains Qi Lolita elements. As the Cure of Historical Fiction, her powers are gemstone based; specifically she uses pearls.
After her was Cure Gatsby (book: The Great Gatsby), otherwise known as Doris Blakely. She’s on the school lacrosse team, the Poe Ravens. She’s also the only one who can drive (and also owns her own car), so she ends up driving the other girls to go fight the BookBurner Gang. She wears green, and her costume contains flapper elements. As the Cure of Modernism, her powers are glass based.
The final cure found was Cure Eyre (book: Jane Eyre), otherwise known as Charlotte Bell. She wants to be an art teacher. She grew up in the foster care system, and ends up involved in a love triangle with Helen Brunswick (a sickly girl with ADHD) and Adam Rochester (an emo boy who might have connections to the BookBurner Gang; Charlotte has babysat for his little sister Adelina). She wears a pale blue that could easily be mistaken for white, and her costume contains pastel goth elements. As the Cure of Gothic Literature, her powers are ice based.
IDK IF ANYONE WOULD DO THIS BUT SEND ME A THEME AND I’LL MAKE A FANCURE TEAM BASED ON IT
#pretty cure (general)#fancure#to kill a mockingbird#bless me ultima#the good earth#the great gatsby#jane eyre#mooncat adoption center#no i will not make a contract#shining literary pretty cure#my magical girls
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Nansook Hong is welcomed to the TIME room. October 1998
A conversation with Nansook Hong, former daughter-in-law of the Rev. Sun Myung Moon.
Transcript from the October 13, 1998 event
Timehost: Welcome to the TIME room! We are very pleased to have with us tonight Nansook Hong, the former daughter-in-law of the Rev. Sun Myung Moon, leader of the Unification Church, and the author of the recent book ‘In the Shadow of the Moons, my life in the Reverend Sun Myung Moon’s family.’ Nansook Hong: Thank you for having me. Timehost: Thank you for joining us... Your book talks a lot about the goings on within the Moon inner circle, about how their lifestyle contradicts with their professed beliefs... let’s start with this question...
wonders123 asks: You started out as a Moonie – and you believed everything he said? Nansook Hong: Well, I was born into the church, and I was taught the church doctrine, since I was very little, in Sunday school. In addition to Bible stories, I learned the ‘Divine Principle,’ the book of the church. It’s supposed to be the divine revelations of God. And yes, I did believe. Yes, I believed that Moon was the messiah. However, along the way, as I got to see Moon as a person, an egocentric person, who believed that the whole world revolved around him. Especially when he spoke about his understanding of God, as someone who revolves around Moon and has to follow Moon, that’s when I began to question him. So I had a different view of him from afar, but once I was a member of the family, and had a chance to see him very closely, it was a different picture. Members don’t really have a chance to see Rev. Moon as closely as I did.
Timehost: Could you state what the core beliefs of the Unification Church are – so that we’re all clear? How are they different from mainstream Christianity? Nansook Hong: Well, Rev. Moon claims to be the messiah. He claims that Jesus came to him when he was 16. And he says that Jesus says that he failed since he didn’t establish the ideal family. So Jesus had the spiritual foundation. Because he was crucified, he asked Rev. Moon to fulfill the mission that Jesus failed. And Reverend Moon accepted. I think that’s the primary difference. Christians believe that Jesus was the messiah. While Moonies believe that Rev. Moon is the Second Coming. He and his wife are called the True Parents. Rev. Moon is the True Father. His wife is the True Mother. And they are meant to be the perfect family. And they are the ones who are going to teach us true family values and establish the Kingdom of Heaven [on earth]. Rev. Moon has been proclaiming that he has established his ideal family, and fulfilled his mission, and when I pinpointed that his family is just as dysfunctional as any other family – or more than most – then I think his theology falls apart.
waikiki96815 asks: What was the final straw that prompted you to leave? Nansook Hong: There were a lot of factors. Initially it was my disillusionment about Moon. Also my ex-husband. I believed that my mission was to be a good wife, and that my mission was to help him change. But he had no desire to change. The elders, the leaders of the church, had only political motives, and greed. Also, the physical abuse from my ex-husband was intolerable. And the environment that my children were growing in up was not healthy. When I saw my children beginning to act the same as my aunts and uncles – like brats – I knew that I had to take them out. I also knew that at some point in the future I would be beaten to death by my ex. But it was a difficult break. Because all I knew my life was the church. I had five children. I had to go through lots of soul searching. But I knew that I had to go.
Timehost: But was it just lack of respect to elders... could you detail the problems that plague the Moon family? Nansook Hong: First of all, I began to question whether Rev. Moon was the messiah. He was a very unfair person. I didn’t see any respect – or love – coming from him [in] his relationships with his closest members and children. He wasn’t a good father. My ex is still angry at him for not having his father around growing up. Moon had an excuse – he always blamed somebody else. The family itself basically had no respect for people. These are not the kind of people I view as being religious. Even though I began to question whether Moon was the messiah, I still clung on to the belief system that I had – that I was called by God. And the fact that Moon was incredibly selfish when he talked about sacrifice for others. It was not consistent with the idea I had about messiahship. I came to the conclusion on my own, being with the Rev. Moon’s family for fourteen years, that he could not be the messiah.
goopster345 asks: Do you ever miss anything about living with the Moons? Nansook Hong: Nope.
religious778 asks: How come so many establishment types seem to support Moon? Nansook Hong: I think first of all, there are other organizations that have minority status, and they think that if one organization is persecuted, they could be next. And Moon spends a lot of money promoting himself. He has lots of organizations that he’s founded, but those organizations don’t go out and tell people they’re started by Moon. So there are science conferences, and journalists’ conferences that hide what they are about. But it’s basically about turning everybody into Moonies. Timehost: The Washington Times in America is one organization run by Moon, can you cite the names of any others? Nansook Hong: The University of Bridgeport, Atlantic Video, the Manhattan Center Studio. Timeguest: There are newspapers all over: [the Segye Ilbo in Korea, the Sekai Nippo in Japan, the Tiempos del Mundo in Argentina, the Ultimas Noticias in Uruguay, the Middle East Times, etc.] Timeguest: Il-Hwa which is a pharmaceutical company. Timehost: You single out former Pres. George Bush and his wife for criticism in being willing to appear at Moon-sponsored functions, knowing full well where the money is coming from... why do you think they do it, and do you know if they’ve read your book? Nansook Hong: I don’t know whether they read the book. Why do I think they do it? I don’t know. I read that Bush said that as long as Moon promotes family values, Bush will promote him. Timeguest: But Moon uses idealism to get to people – and he doesn’t practice what he preaches. Moon uses – and pays – lots of famous people. Bush is one example. Jack Kemp and Barbara Walters are others. He does it to gain credibility. And I think that Bush has been helping Moon to achieve his goal. religious778 asks: Are the Moons arms dealers? Nansook Hong: Arms dealers – his son basically manufactures guns. Guns. They have an arms manufacturing factory. My ex owned over 60 guns. They like shooting animals. My ex enjoyed torturing animals – that to me says something about a person. And that’s not the character I see in people who profess to be leaders. Thorntree asks: How does a drug company or university promote Moon? What do they actually do? Nansook Hong: Initially, their approach is to get people’s attention. They all have different tactics. A drug company is there to make money. If people know that it’s his company, it helps to build his credibility. A university helps to shape people’s minds – and it’s very important to Moon to shape young peoples’ minds. Moon buys universities when they are in trouble financially, and he wants his people to teach Unification Thought. But it happens gradually. They talk about world peace, family values – which sound good. Idealistic people are fascinated and curious about these ideas. Once people are brought into that realm, they introduce church principles, little by little, and eventually they reveal that the Rev. Moon is the messiah. It is a slow process, and the church is pretty good at what they are doing. I think in the beginning, there’s a nice honeymoon phase. People in the beginning phases feel that they are loved and respected. That’s how they get into peoples’ hearts. Timehost: In your book, you write about trips from Japan with thousands of dollars in cash stuffed into your suitcases to finance U.S.-based Moon operations. This next question ties into that. statefarmer asks: Nansook, can you give examples of payoffs? Nansook Hong: I don’t think I can give specific examples. The Moonies are very, very wealthy. They come into this country with lots of cash but that’s mainly for Moon and his family, for their gambling and shopping sprees. But the main source of money that supports the US projects comes from Japan. Timehost: Have they changed their business practices any since Moon was imprisoned for tax evasion? Nansook Hong: No, I don’t think so. They’ve always had two books. One for the IRS and one for themselves. Moon has always seen himself as above the law. I saw money laundry from one place to the other. They try to separate the church from the business organization very carefully. puffy_law asks: How did you manage to get away from the powerful Moon family? Nansook Hong: I had to plan for seven months. I knew that if the church or the family found out – actually the church IS the family – if one of them found out about my plan to escape, that would be the end of my existence. So I had to plan very carefully. I first of all went to lawyers because I wanted custody of my children. My brother and my best friend helped out. I rented a storage unit and started packing stuff away. I had a little money saved. I put down the downpayment for a house in Massachusetts. I basically ran with my five kids. I ran out of the compound, and after that it was a long legal battle for three years. First of all, they tried to make me come back. One way was to try to squeeze me financially as much as they could. And after all, I had five children. I was pretty scared of my ex. I got a restraining order. They had a large amount of cash to pay lawyers, I didn’t. I always had to look over my shoulder. I was afraid that they were going to kidnap the kids. I asked for child support – of course they refused. My ex declared bankruptcy. This person who had everything said he was broke. They refused to pay child support. But in the end, after a long battle, they paid me something. They didn’t want me to talk. But I wanted to write this book. They tried to sue me to prevent the book from being published. They argued that it would hurt the children. The case was dismissed, but I was stuck with huge lawyers’ fees. It was a physical as well as an emotional struggle. I wanted to move away from the Moons. And the book helped me to do that. I had to reflect on my life and my past. It gave me a different perspective. It was therapeutic – the process helped me heal. I’m getting letters from people who left the church, and who find the book enlightening. So I have my satisfaction. Xgojin asks: Are you in danger with the Moonies now? Nansook Hong: I’ve received some threats. Some members of the church and family members still come around and want me to come back. If I were to go back then they could say it was my fault not theirs. I heard that my ex-husband has been making threats, violent threats, against me. He apparently said, “I should have killed her when I had the chance.” And I think he feels that way. I was on a book tour, and I remember thinking on the plane, would I be the next Nicole Brown Simpson. But I decided that fear was not going to control my life. So I am concerned about that the family or the church or my ex will do, but I’m happy with my life now. KatBird_27 asks: I saw you on NW Afternoon a week or so ago and I was wondering if you allow your children to see your ex-husband? Nansook Hong: He has supervised visitation. I had a problem with my ex-husband, but those are adults’ problems. But I hope that he can clean up his act and become a good father. I think that’s crucial for kids. goopster345 asks: What is your life like now? Nansook Hong: Mainly I’m a mom of five children. That job consumes 99 percent of my life. And that’s pretty tough. Right now, I’m also working in a battered women’s shelter, and that’s pretty fulfilling. I’m also working to get a degree in social work. Timehost: We’re almost out of time. Let’s take one last question. Many people have speculated that the Moonies won’t survive the Rev. Moon.This next question ties into that... questioner765 asks: Do you think that your book will change the way people view Moon? Nansook Hong: I don’t know the answer to that. I wish the answer were yes, but I don’t know. I know that certain people have changed their minds about Moon because of the book. Timeguest: But lots of members will blindly believe what they want to believe. Nansook Hong: It’s their way of life – for some, it’s a paycheck. All their friends are members. They have no life outside the church. It’s their whole life. I hope it makes some difference. And I know for a fact that that is the case. Timehost: That’s all the time we have for tonight, but do you have any closing thoughts before we end, Nansook? Nansook Hong: Moon claims that he has absolute power since he is the messiah. But absolute power corrupts people, and I think that’s what’s happening to Moon and his family and the church, and I think there is an hypocrisy in the church. And I didn’t experience love in the family that professes to be a family of love. There are lots of good people in the church, but I think that Moon has touched so many peoples’ lives in the wrong way. And I think that’s evil. Timehost: Thank you very much for joining us, Nansook. And good luck for your life ahead.
Hyo Jin Moon came to court in Concord in the company of no fewer than four high-priced attorneys to fight Nansook Hong
Second Generation gives a testimony on life with Hyo Jin Moon
Nansook Hong’s video gets nearly one million hits with FULL TRANSCRIPT of the ‘60 Minutes’ with Mike Wallace
Nansook Hong was interviewed by Rachael Kohn in 1999
Robert Parry reviews Nansook Hong’s 1998 book ‘In the Shadow of the Moons’
A review of Nansook Hong’s revealing book
Black Heung Jin (Cleophas Kundiona) by Nansook Hong
Nansook Hong – [C-Span] Book Discussion – ‘In The Shadow of the Moons’ with FULL TRANSCRIPT
Hyo-jin Moon jailed for 90 days for failing to pay Nansook Hong as ordered by the court
The public disintegration of Sun Myung Moon and Hak Ja Han’s True Family
Book in four parts, English:
Nansook Hong – In The Shadow Of The Moons, part 1
Nansook Hong – In The Shadow Of The Moons, part 2
Nansook Hong – In The Shadow Of The Moons, part 3
Nansook Hong – In The Shadow Of The Moons, part 4
Book in four parts, French:
« L’ombre de Moon » par Nansook Hong, partie 1
« L’ombre de Moon » par Nansook Hong, partie 2
« L’ombre de Moon » par Nansook Hong, partie 3
« L’ombre de Moon » par Nansook Hong, partie 4
Book in four parts, German:
Nansook Hong – Ich schaue nicht zurück, Tiel 1
Nansook Hong – Ich schaue nicht zurück, Teil 2
Nansook Hong – Ich schaue nicht zurück, Teil 3
Nansook Hong – Ich schaue nicht zurück, Tiel 4
Nansook Hong information in Spanish:
Nansook Hong entrevistada en español
‘A la Sombra de los Moon’ por Nansook Hong en español
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FITNESS RETAIL FINDS RECOVERY AT THE BAR
By Nancy Trent
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Mat health – You can be getting more than your workout off your mat. HealthyLine’s infrared gemstone mats release infrared rays and negative ions to improve your body’s overall wellness levels and manage pain.
As seen in Club Insider
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Ultima Pharmaceutical: A Leader in Anabolic Steroids
When it comes to enhancing athletic performance and muscle growth, Ultima Pharmaceutical stands out as a prominent name in the industry. Being the manufacturer of high quality anabolic steroids, Ultima Pharmaceutical offers the products that are in demand on bodybuilders, athletes, and everyone who is interested in fitness. Below is a brief insight of some of the factors that put Ultima Pharmaceutical at a vantage point in this particular niche. Premium Quality and Reliability
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Fractal Structure of Microcrystalline Cellulose Obtained by Method of Spray Drying-Juniper Publishers
JUNIPER PUBLISHERS- ACADEMIC JOURNAL OF POLYMER SCIENCE
Abstract
In this research, a fractal structure of beads of different sizes obtained by spray-drying of aqueous dispersions of microcrystalline cellulose (MCC) was studied. These beads are formed as a result of aggregation of rod-shaped cellulose nanocrystalline particles (CNP). It was found that increasing the average radius (R) of the formed MCC beads results in increased porosity (P) and reduced density (ρ). The dependences of P and ρ on scale factor (R/r) can be expressed by power-law equations: p=(R/r)k-dp and p-d (R/r)DP-K ,where the fractal dimensions PD= 2.887 andPD=2.986 are close to Euclidean dimension E=3 for three-dimensional space; r=3nm is radius of cellulose nanocrystalline particles, Po = 0.03cm3/g is porosity and d=1.585g/cm3 is true density (specific gravity) of CNP, respectively. Thus, with the increase in the size of formed MCC beads, the order in the packing of the beads is distorted conforming to theory of diffusion-limited aggregation process.
Keywords: Microcrystalline cellulose (MCC); Spray-drying; MCC bead; Size; Porosity; density; Fractal dimension
Introduction
It is known that various natural and artificial objects and phenomena can be considered as fractals, distinctive features of which are scale invariance (self-similarity) and fractional dimension [1,2]. The theory of fractals is widely used in engineering, mathematics, biology, physics, chemistry and other areas. According to this theory, the fractal dimension (D) of an object can be determined by logarithmization of power-law dependence of structure or property on scale factor. In particular, the theory of fractals was applied for description of structure and properties of such wide-spread natural biopolymer as cellulose and also of diverse cellulose materials.
For instance, cellulose fibers were studied by a method of low-temperature nitrogen sorption to measure the dependence of cumulative volume on radius of various pores expressed by the power-law function, from which the fractal dimension from 2.88 to 2.95 was determined [3]. In another research [4], the fractal structure of pores in various cellulose materials was studied by nitrogen and water vapor sorption methods; in the case of nitrogen sorption the fractal dimension of pores was from 2.13 to 2.50, whereas sorption of water vapor gave the fractal dimension of pores less than 1.5 due to altering of cellulose structure under effect of water. The study the distribution of nano-scale cellulose aggregates by method of small-angle X-ray scattering permitted to calculate the fractal dimension D=2.10 [5].
The main purpose of this research was to study the fractal characteristics of Microcrystalline Cellulose (MCC) beads with different sizes prepared by method of spray drying, which can be used as excipient in pharmaceutics and medicine, as well as filler in various composite materials.
Experimental
Material
The initial material was chemical grade cotton cellulose (99 % α-cellulose, DP=2700) of Hercules Inc.
Method of preparation beads of MCC
Cotton cellulose was hydrolyzed with boiling 1.5M sulfuric acid at the acid/cellulose ratio 10 for 1h followed by filtration of the acid and washing of MCC on the filter to neutral pH [6]. The resulting wet cake of MCC was diluted with distilled water to obtain 1-5% dispersions, which were disintegrated in Waring blender at 15,000rpm for 10min to break the agglomerates. To produce beads, the aqueous dispersions of MCC were spray-dried using a lab drier of Pilotech at the following conditions: feeding 10ml/min, air pressure 0.2MPa, inlet temperature 120oC and outlet temperature 60oC.
Sieve analysis
MCC beads of different sizes were separated by screening through sieves with mesh of 80-100, 140-170, 230-270 and 450-635. The average radius of the beads was shown in the Table 1. With rise of the concentration of MCC dispersion from 1 to 5%, an increase in the yield of larger beads was observed.
Scanning electron microscopy
Shape of MCC beads were investigated by electron microscope Hitachi S-4700.
Wide-angle X-ray scattering (WAXS)
Nanostructure of MCC beads was investigated by WAXS method using Rigaku-Ultima Plus diffractometer (CuKa - radiation, l=0.15418nm) [7, 8]. Lateral size (L) of cellulose nanocrystalline particles (CNP) in direction perpendicularly to [200] planes of crystalline unit cell were calculated by modified Scherrer equation taking into account the contribution of instrumental factor and lattice distortions to width of crystalline peak. Minimum radius of CNP was calculated as follows: r = 0.5L.
Sorption method
Sorption of hexane vapor by MCC beads was measured at 25oC with the use of a vacuum Mac-Ben apparatus having helical spring quartz scales [9]. The porosity [p,cm3/g] the beads was calculated by the equation:
where V is total volume of pores (cm3 ) measured at relative vapor pressurep/p0 m is mass of the dry sample (g).
Results and Discussion
SEM studies showed that spray-dried MCC beads have ellipsoidal or spherical shape and contain small rod-like particles (Figure 1). As known, cellulose is semicrystalline linear polysaccharide that consists of elementary nanofibrils and their bundles called microfibrils [10]. Furthermore, each nano-scale fibril is built of ordered rod-like nanocrystallites and low ordered amorphous nanodomains. The three-dimensional ordered nanocrystallites are strong and inaccessible structural elements. As against, the low-ordered amorphous domains are weak and accessible segments of the fibrils. Therefore, cleavage of amorphous domains at the acid hydrolysis leads to formation of rod-shaped nanocrystalline particles (CNP). As a result of spraydrying, the rod-shaped CNP are aggregated by their side surfaces and forms micron sized beads of microcrystalline cellulose with various average radius.
The structural studies showed that CNP isolated from plant biomass have lateral sizes of 4-8nm and length of 100-200nm [11]. As it follows from WAXS results, the average lateral size (L) of CNP made of cotton cellulose is 6nm and their average radius (r) is 3nm or 0.003μm (Table 2).
The study of vapor sorption of inert organic liquid (hexane) revealed that the porosity of MCC beads varies in the range from 0.0757 to 0.0931 cm3/g (Table 3). Moreover, when the average size of the beads increases, their porosity rises.
The dependence of porosity (P) on scale factor (R/r) can be expressed by a power-law function:
where Po is porosity of CNP, DP is fractal dimension; E=3 is Euclidean dimension for three-dimensional space.
After logarithmizing of the function (2), a linear graph was drawn (Figure 2), from which the values of Po = 0.03 [cm3/g]=2.887 were found.
Along with porosity, it is also possible to calculate the density of MCC beads, as follows:
where Vc = d-1 is specific volume of CNP having crystallinity about 80% and true density (specific gravity) d=1.585g/cm3 [10].
Using ρ values and scale factor [R/r](Table 3), the linear dependence can be obtained (Figure 3) by logarithmizing of the function:
From the linearized graph (Figure 3), the value of Dρ =2.986 was calculated.
The results have shown that the small beads contain more densely packed aggregates of CNP than the large MCC beads. According to DLA-theory [2, 12-14], such structural feature indicates that the formation of MCC beads occurs via diffusionlimited aggregation process.
Conclusion
Rod-shaped crystalline nanoparticles (CNP) of cotton cellulose with radius r = 3 nm have a compact packing with high true density (specific gravity) d=1.585g/cm3 and negligible porosity Po=0.03 cm3/g During spray-drying a lateral aggregation of rod-shaped CNP occurs. Moreover, with the development of aggregation process of CNP and increase in size of the formed MCC beads, the order in the packing is distorted conforming to theory of diffusion-limited aggregation process. Consequence of this phenomenon is increase in porosity and decrease in density with the rise in size (average radius R) of the beads. The dependences of porosity (P) and density (ρ) on scale factor (R/r) can be expressed by the following power-law equations:
where the fractal dimensions DP = 2.887 and Dρ = 2.986 are close to Euclidean dimension E=3 for three-dimensional space.
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