#Timothy C. Westphalen

[majestativa]

My heart is open to you alone. My soul is devoted to dark melodies.

— Alexander Blok, Aleksandr Blok’s Trilogy of Lyric Dramas, ‘The King on the Square’, transl by Timothy C. Westphalen, (2003)

[cancersfakianakis1]

β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer

Publication date: 12 November 2018

Source: Cancer Cell, Volume 34, Issue 5

Author(s): Bernhard W. Renz, Ryota Takahashi, Takayuki Tanaka, Marina Macchini, Yoku Hayakawa, Zahra Dantes, H. Carlo Maurer, Xiaowei Chen, Zhengyu Jiang, C. Benedikt Westphalen, Matthias Ilmer, Giovanni Valenti, Sarajo K. Mohanta, Andreas J.R. Habenicht, Moritz Middelhoff, Timothy Chu, Karan Nagar, Yagnesh Tailor, Riccardo Casadei, Mariacristina Di Marco

https://ift.tt/2FgZg7p

[majestativa]

I know your soul’s singing And love your dark speeches.

— Alexander Blok, Aleksandr Blok’s Trilogy of Lyric Dramas, ‘The King on the Square’, transl by Timothy C. Westphalen, (2003)

[majestativa]

Do you believe that destruction is liberating?

— Alexander Blok, Aleksandr Blok’s Trilogy of Lyric Dramas, ‘The King on the Square’, transl by Timothy C. Westphalen, (2003)

[majestativa]

Yes, speak, my princess, In such a way that vivid dreams Flow before me, Vivid dreams of a land that has never been.

— Alexander Blok, Aleksandr Blok’s Trilogy of Lyric Dramas, ‘The King on the Square’, transl by Timothy C. Westphalen, (2003)

[majestativa]

You’re sick. Live more simply. You are a poet, a senseless singing being; however, you are fated to express the thoughts of others. They just don’t know how to state everything that you say. Woe to you, if you prompt the people with their own secret, crazy thoughts.

— Alexander Blok, Aleksandr Blok’s Trilogy of Lyric Dramas, ‘The King on the Square’, transl by Timothy C. Westphalen, (2003)

[majestativa]

I searched for a hero in you.

— Alexander Blok, Aleksandr Blok’s Trilogy of Lyric Dramas, ‘The King on the Square’, transl by Timothy C. Westphalen, (2003)

[majestativa]

I hear your approach. Again you arise above the dust, Like a vision, momentary. You will vanish in the new dust. A new wind will bear you away.

— Alexander Blok, Aleksandr Blok’s Trilogy of Lyric Dramas, ‘The King on the Square’, transl by Timothy C. Westphalen, (2003)

[majestativa]

With your child-like soul, you’re truer than anyone to me.

— Alexander Blok, Aleksandr Blok’s Trilogy of Lyric Dramas, ‘The King on the Square’, transl by Timothy C. Westphalen, (2003)

[majestativa]

Her father’s creative intoxication and the rage of the last several generations are in her.

— Alexander Blok, Aleksandr Blok’s Trilogy of Lyric Dramas, ‘The King on the Square’, transl by Timothy C. Westphalen, (2003)

[majestativa]

At their hour of death everyone recalls the sublime, that which had been forgotten. She will infect them with her reckless beauty.

— Alexander Blok, Aleksandr Blok’s Trilogy of Lyric Dramas, ‘The King on the Square’, transl by Timothy C. Westphalen, (2003)

[majestativa]

Listen!

— Alexander Blok, Aleksandr Blok’s Trilogy of Lyric Dramas, ‘The King on the Square’, transl by Timothy C. Westphalen, (2003)

[majestativa]

The city terrifies me. All the inhabitants have lost their minds. They build their happiness on some sort of insane dream.

— Alexander Blok, Aleksandr Blok’s Trilogy of Lyric Dramas, ‘The King on the Square’, transl by Timothy C. Westphalen, (2003)

[majestativa]

— Alexander Blok, Aleksandr Blok’s Trilogy of Lyric Dramas, ‘The King on the Square’, transl by Timothy C. Westphalen, (2003)

[majestativa]

Your visions are alien. Your words too are alien. I am breathing your tale.

— Alexander Blok, Aleksandr Blok’s Trilogy of Lyric Dramas, ‘The King on the Square’, transl by Timothy C. Westphalen, (2003)

[cancersfakianakis1]

β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer

Publication date: Available online 14 December 2017 Source:Cancer Cell Author(s): Bernhard W. Renz, Ryota Takahashi, Takayuki Tanaka, Marina Macchini, Yoku Hayakawa, Zahra Dantes, H. Carlo Maurer, Xiaowei Chen, Zhengyu Jiang, C. Benedikt Westphalen, Matthias Ilmer, Giovanni Valenti, Sarajo K. Mohanta, Andreas J.R. Habenicht, Moritz Middelhoff, Timothy Chu, Karan Nagar, Yagnesh Tailor, Riccardo Casadei, Mariacristina Di Marco, Axel Kleespies, Richard A. Friedman, Helen Remotti, Maximilian Reichert, Daniel L. Worthley, Jens Neumann, Jens Werner, Alina C. Iuga, Kenneth P. Olive, Timothy C. Wang Catecholamines stimulate epithelial proliferation, but the role of sympathetic nerve signaling in pancreatic ductal adenocarcinoma (PDAC) is poorly understood. Catecholamines promoted ADRB2-dependent PDAC development, nerve growth factor (NGF) secretion, and pancreatic nerve density. Pancreatic Ngf overexpression accelerated tumor development in LSL-Kras+/G12D;Pdx1-Cre (KC) mice. ADRB2 blockade together with gemcitabine reduced NGF expression and nerve density, and increased survival of LSL-Kras+/G12D;LSL-Trp53+/R172H;Pdx1-Cre (KPC) mice. Therapy with a Trk inhibitor together with gemcitabine also increased survival of KPC mice. Analysis of PDAC patient cohorts revealed a correlation between brain-derived neurotrophic factor (BDNF) expression, nerve density, and increased survival of patients on nonselective β-blockers. These findings suggest that catecholamines drive a feedforward loop, whereby upregulation of neurotrophins increases sympathetic innervation and local norepinephrine accumulation.

Graphical abstract

Teaser

Renz et al. show that catecholamines promote ADRB2-dependent pancreatic ductal adenocarcinoma development and secretion of neurotrophins (NT), which in turn promote tumor innervation leading to increased NE and tumor growth. Blockade of ADRB2 or NT receptors improves gemcitabine's therapeutic effect. http://ift.tt/2j7cDth