#TargetScan

[addonhealthcare]

View this post on Instagram

A post shared by addon Scans & Labs/Bengaluru (@addonscanslabs)

🤰 Don't miss these 4 Scans During Pregnancy! 🤰

1️⃣ Early Pregnancy Scan (Between 5-10 Weeks) 2️⃣ NT Scan (Between 12-13 Weeks) 3️⃣ Anomaly Scan/TIFFA/Target Scan (Between 19-22 Weeks) 4️⃣ Growth Scan/BPS (Between 28-37 Weeks)

Call Now for Pregnancy Scan at +91 9900811118! 📞💖

[refaudit]

Application pour smartphone: TargetScan (gratuit)

je pense que bcp d’entre-vous connaissent cet appli qui enregistre vos armes et tout vos tirs, calcule les points et évalue ceux-ci. Mais dans le doute je vous en fais une démo par l’image….je la redécouvre après une longue absence de tir suite à une inflammation musculaire qui me paralysait le buste.  http://dlvr.it/T5VVrB

[rnomics]

Nutrients, Vol. 16, Pages 873: Ferroptosis Altered micro#RNAs Expression in HT-1080 Fibrosarcoma Cells Based on Small #RNA Sequencing and Bioinformatics Analysis

Iron is an essential trace element in the human body. However, excess iron is harmful and may cause ferroptosis. The expression and role of micro#RNAs (#miRNAs) in ferroptosis remain largely unknown. A model of ferroptosis induced by ferric ammonium citrate in HT-1080 cells was established in this study. The #miRNAs expression profiles of the control and iron groups were obtained using small #RNA sequencing and verified using qRT-PCR. A total of 1346 known #miRNAs and 80 novel #miRNAs were identified, including 12 up-regulated differentially expressed #miRNAs (DE-#miRNAs) and 16 down-regulated DE-#miRNAs. SP1 was the most important upstream transcription factor regulating DE-#miRNAs. The downstream target genes of DE-#miRNAs were predicted based on miRDB, TargetScan, and miRBase databases, and 403 common target genes were screened. GO annotation and KEGG analysis revealed that the target genes were mainly involved in various biological processes and regulatory pathways, especially the MAPK signaling pathway and PI3K-Akt signaling pathway. Afterwards, a target genes network was constructed using STRING and Cytoscape, and the hub genes were compared with the ferroptosis database (FerrDb V2) to discover the hub genes related to ferroptosis. EGFR, GSK3B, PARP1, VCP, and SNCA were screened out. Furthermore, a DE-#miRNAs-target genes network was constructed to explore key DE-#miRNAs. hsa-miR-200c-3p, hsa-miR-26b-5p, and hsa-miR-7-5p were filtered out. Comprehensive bioinformatics analysis of #miRNAs and its upstream and downstream regulation in ferroptosis in HT-1080 cells using small #RNA sequencing is helpful for understanding the role of #miRNAs in iron overload-related diseases and ferroptosis-targeted therapy for #cancer. https://www.mdpi.com/2072-6643/16/6/873?utm_source=dlvr.it&utm_medium=tumblr

[rnewspost]

Scientists find that microRNA affects inflammation in lupus disease.

Conservation trends of miR-128 and miR-148a target sites with “conserved overlap.” A, B Cumulative distribution of the number of species in which the indicated site types of miR-128-3p (A) and miR-148a-3p (B) are conserved across 84 species. Conserved and non-conserved sites are defined by TargetScan. Target sites are classified according to Fig. 3A. P values were calculated by the one-tailed…

[thereallong]

Fast gapped read alignment with bowtie 2

Inhibition of autophagy attenuated Huaier-induced cell death. In addition, electron microscopy, MDC staining, accumulated expression of autophagy markers and flow cytometry revealed that Huaier extract triggered autophagy. Huaier treatment inhibited cell viability in all three cell lines and induced various large membranous vacuoles in the cytoplasm. Here, we investigated the role of autophagy in Huaier-induced cytotoxicity in MDA-MB-231, MDA-MB-468 and MCF7 breast cancer cells. Huaier extract is attracting increased attention due to its biological activities, including antitumor, anti-parasite and immunomodulatory effects. It drives the latest version of TargetScan (v7.0 ), thereby providing a valuable resource for placing miRNAs into gene-regulatory networks. This model, which considers site type and another 14 features to predict the most effectively targeted mRNAs, performed significantly better than existing models and was as informative as the best high-throughput in vivo crosslinking approaches. Accordingly, we developed an improved quantitative model of canonical targeting, using a compendium of experimental datasets that we pre-processed to minimize confounding biases. Here, we show that recently reported non-canonical sites do not mediate repression despite binding the miRNA, which indicates that the vast majority of functional sites are canonical. MicroRNA targets are often recognized through pairing between the miRNA seed region and complementary sites within target mRNAs, but not all of these canonical sites are equally effective, and both computational and in vivo UV-crosslinking approaches suggest that many mRNAs are targeted through non-canonical interactions.

[healthtimetaylor]

The combination of gastrodin and rhynchophylline exerts neuroprotective effects by preventing ischaemia-induced inflammasome activation.

PMID:  Life Sci. 2019 Oct 11 ;239:116935. Epub 2019 Oct 11. PMID: 31610203 Abstract Title:  Gastrodin combined with rhynchophylline inhibits cerebral ischaemia-induced inflammasome activation via upregulating miR-21-5p and miR-331-5p. Abstract:  BACKGROUND: The protective effects of gastrodin and rhynchophylline in ischaemic injury have been reported. However, the underlying mechanism and the effect of the combination of these two drugs in ischaemic injury remain unclear. Herein, we aimed to explore the effects of the combination of gastrodin and rhynchophylline on ischaemia-induced inflammasome activation as well as the underlying mechanism.METHODS: Middle cerebral artery occlusion (MCAO) mice and oxygen glucose deprivation (OGD)-treated BV2 cells were used as in vivo and in vitro models of ischaemia, respectively. Cerebral injury was determined by TTC staining, H&E staining and neurological deficit scores. The effects of the combination of gastrodin and rhynchophylline on inflammasome activation were measured by the MTT assay, Western blotting and ELISA. The expression of miR-21-5p and miR-331-5p was measured by qRT-PCR. The potential binding between miR-21-5p and TXNIP and between miR-331-5p and TRAF6 was analysed with Targetscan and a luciferase assay.RESULTS: MCAO-induced tissue infarction, neurological deficits, inflammasome activation, and downregulation of miR-21-5p and miR-331-5p were all mitigated by the combination of gastrodin and rhynchophylline. In OGD-treated BV2 cells, the combination of gastrodin and rhynchophylline also alleviated inflammasome activation and restored the expression of miR-21-5p and miR-331-5p. TXNIP and TRAF6 were confirmed to be targets of miR-21-5p and miR-331-5p, respectively. Moreover, OGD-induced inflammasome activation was attenuated by the overexpression of either miR-331-5p or miR-21-5p and was further attenuated by the overexpression of both. Finally, we demonstrated that a miR-21-5p inhibitor and/or a miR-331-5p inhibitor counteracted the protective effects of gastrodin and/or rhynchophylline.CONCLUSIONS: The combination of gastrodin and rhynchophylline exerts neuroprotective effects by preventing ischaemia-induced inflammasome activation via upregulating miR-21-5p and miR-331-5p.

read more

[binaryoptionsmasterr]

Using Stochastic With Support and Resistance in Trading

7 min read 

Most professional traders agree that Forex requires setting up stop-loss and profit targets, which can be even more important than the entry point itself. Due to the fact that currency pairs tend to move within well established support and resistance targets, useful stop-losses and profit-taking targetscan be found within those ranges.

  source http://bit.ly/2zzYG1I/

[cancersfakianakis1]

Emerging roles of circRNA_NEK6 targeting miR-370-3p in the proliferation and invasion of thyroid cancer via Wnt signaling pathway.

Emerging roles of circRNA_NEK6 targeting miR-370-3p in the proliferation and invasion of thyroid cancer via Wnt signaling pathway.

Cancer Biol Ther. 2018 Sep 12;:1-14

Authors: Chen F, Feng Z, Zhu J, Liu P, Yang C, Huang R, Deng Z

Abstract OBJECTIVE: To identify the significantly altered circRNAs and mRNAs in thyroid cancer, investigate their target miRNAs and determine their biological functions. METHODS: The differentially expressed circRNAs, mRNAs and pathways in thyroid cancer were identified by microarray analysis and gene set enrichment analysis (GSEA). The correlative circRNAs and mRNAs were found out through Pearson correlative analysis. The common target miRNAs of circNEK6 and FZD8 related to thyroid cancer was screened out through Targetscan, miRanda and HMDD analysis. The mRNA and protein expressions in thyroid cancer tissues and cells were detected by qRT-PCR and western blot. CircRNA was confirmed by the RNase R digestion and nucleic acid electrophoresis. The target relationships were verified by the dual luciferase reporter assay. Cell viability, invasion and apoptosis were determined by MTT assay, Transwell assay and flow cytometry, respectively. RESULTS: CircNEK6 and FZD8 were significantly up-regulated in thyroid cancer, with strong correlations. The Wnt signaling pathway was activated in thyroid cancer. MiR-370-3p was the common target miRNA of circNEK6 and FZD8, and it was down-regulated in thyroid cancer. Overexpression of circNEK6 and FZD8 could promote the growth and invasion of thyroid cancer cells, while up-regulation of miR-370-3p could suppress thyroid cancer progression and inhibit the Wnt signaling pathway. MiR-370-3p's effect on thyroid cancer cells could be rescued by circNEK6 or FZD8. CONCLUSION: CircNEK6 promoted the progression of thyroid cancer through up-regulating FZD8 and activating Wnt signaling pathway by targeting miR-370-3p.

PMID: 30207869 [PubMed - as supplied by publisher]

https://ift.tt/2xaD7RO

[tumimmtxpapers]

5'-UTR and 3'-UTR Regulation of MICB Expression in Human Cancer Cells by Novel microRNAs.

5'-UTR and 3'-UTR Regulation of MICB Expression in Human Cancer Cells by Novel microRNAs. Genes (Basel). 2017 Aug 29;8(9): Authors: Wongfieng W, Jumnainsong A, Chamgramol Y, Sripa B, Leelayuwat C Abstract The treatment of cancer through the induction of natural killer group 2, member D (NKG2D) ligands is of interest, but understanding of mechanisms controlling expression of individual ligand is limited. The major histocompatibility complex (MHC) class I chain related protein B (MICB) is a member of NKG2D ligands. We aimed to investigate the role of 3'-untranslated (3'-UTR) and 5'-untranslated regions (5'-UTR) in post-transcriptional regulation of MICB. Nine novel microRNAs (miRNAs) predicted to interact with 3'-UTR and 5'-UTR using TargetScan, RNAhybrid and miBridge were identified. Their regulation of 3'-UTR, 5'-UTR and both 3'- and 5'-UTR sequences of MICB were indicated by the reduction of luciferase activities of luciferase reporter constructs. Mutations of miRNA binding sites at 3'- and 5'-UTRs resulted in increased luciferase activities confirming the regulation of nine candidate miRNAs. In addition, overexpression of candidate miRNAs also down-regulated the expression of reporter constructs. Consequently, the overexpression and inhibition of candidate miRNAs lead to the decreased and increased. MICB protein expressions on the cells tested, respectively. This study has identified a new role of miRNAs in regulation of MICB expression via both 3'-UTR and 5'-UTR sequences applicable for cancer immunotherapy. PMID: 28850101 [PubMed] http://dlvr.it/Pjbp6J

[refaudit]

Application pour smartphone: TargetScan (gratuit)

je pense que bcp d’entre-vous connaissent cet appli qui enregistre vos armes et tout vos tirs, calcule les points et évalue ceux-ci. Mais dans le doute je vous en fais une démo par l’image….je la redécouvre après une longue absence de tir suite à une inflammation musculaire qui me paralysait le buste.  http://dlvr.it/StqtDx

[rnomics]

Bioinformatics analysis of differentially expressed #miRNA-related #mRNAs and their prognostic value in breast carcinoma.

Bioinformatics analysis of differentially expressed #miRNA-related #mRNAs and their prognostic value in breast carcinoma. Oncol Rep. 2018 Apr 23;: Authors: Zhang GM, Goyal H, Song LL Abstract Breast carcinoma is one of the most common types of malignant neoplasms, and is associated with high rates of morbidity and mortality. Altered gene expression is critical in the development of breast #cancer. To identify the important differentially expressed genes and #microRNAs in breast carcinoma, #mRNA (GSE26910, GSE42568, and GSE89116) and #microRNA (GSE35412) microarray datasets were downloaded from the Gene Expression Omnibus database. The differentially expressed #microRNA expression data were extracted with GEO2R online software. The DAVID online database was used to perform a function and pathway enrichment analysis of the key identified differentially expressed genes. A protein-protein interaction (PPI) network was constructed using the STRING online database, and visualized in Cytoscape software. The effect of the expression level of the key identified genes on overall survival (OS) time was analyzed by using the Kaplan-Meier Plotter online database. Furthermore, the online #miRNA databases TargetScan, microT-CDS, and TarBase were used to identify the target genes of the differentially expressed #miRNAs. A total of 254 differentially expressed genes were identified, which were enriched in cell adhesion, polysaccharide binding, extracellular region part and ECM-receptor interactions. The PPI network contained 250 nodes and 375 edges. Five differentially expressed genes were found to be significantly negatively correlated with the differentially expressed #miRNAs, which were potentially also target genes for #miRNAs. Four of the five genes, including AKAP12, SOPB, TCF7L2, COL12A1 and TXNIP were downregulated, and were associated with the OS of patients with breast carcinoma. In addition, a total of 130 differentially expressed #miRNAs were identified. In conclusion, these results constitute a novel model for #miRNA-#mRNA differential expression patterns, and further studies may provide potential targets for diagnosing and understanding the mechanisms of breast carcinoma. PMID: 29693181 [PubMed - as supplied by publisher] http://bit.ly/2FikKeQ #Pubmed

[thegolfrangefinders-blog]

Halo Z9X 900 review

Halo Z9X 900 review

A debt of gratitude is in order for making a trip to perceive what I think about the Wildgame Innovations

Halo Ballistix Z9X laser rangefinder

. This is a financial plan benevolent model, yet it's not short on highlights. The inquiry is, how well does it perform in certifiable use? We should investigate see, what do you say?

The principal thing you might need to know is the thing that you get for your cash. When you unpack the

Ballistix Z9X

, this is what you can hope to discover in the case:

The Wildgame Innovations Halo Ballistix Z9X laser rangefinder itself

Nylon case

CR-2 3-volt lithium battery

Shockingly, you don't get a cord, yet the conveying case is high caliber and fits well.

What's the Range of the Wildgame Innovations Halo Ballistix Z9X

The greatest scope of this 6X laser rangefinder is 900 yards to an exceedingly intelligent focus, with precision to give or take one yard. The publicized range to deer is 300 yards, however I found the gadget was hard to precisely gage separation to something besides a vast white structure from more than around 120 yards.

How Easy is the

Halo Z9X

to Use?

The rangefinder joins one-catch operation, and the catch is extensive and sufficiently finished to make it simple to work even with gloves on. The locally available menu rushes to explore, and I didn't encounter quite a bit of an expectation to learn and adapt in getting used to working this model.

Wildgame Innovations doesn't determine whether the gadget uses completely multicoated optics or just multicoated optics, however it is by all accounts the last mentioned. So far as that is concerned, WI does exclude its rangefinders on its site, which is somewhat discouraging.

The rangefinder'sobjective focal point is a burly 24mm, and you'll see a field of perspective of 368 feet from 1,000 yards. You won't get much eye help out of this puppy, however, since the separation to your eye may be around 15mm. Good fortunes utilizing this model on the off chance that you wear eyeglasses.

Surprisingly more terrible, there is no diopter change on the eyepiece.

How is the Rangefinder Powered?

The Halo Ballistix Z9X utilizes a 3-volt lithium battery, show CR-2. You get one in the container, however I prescribe purchasing an extra to convey with you. This sort of battery is famously hard to discover in rustic zones like where the majority of us tend to chase.

WI has made a fantastic showing with regards to with control utilization, stopping the gadget following a couple of moments of inertia.

What Features Can I Expect?

You'll discover slant pay, for those circumstances when your objective is above or underneath you. This is particularly useful for bowhunters, yet it likewise has huge convenience for rifle shooters. You'll likewise have the capacity to choose from single target mode and output mode, enabling you to rapidly get reaches to various focuses with a solitary press of the power catch. There are no focusing on modes, however, so you're screwed over thanks to getting the range to whatever protest fills the reticle the most.

What's the Light Gathering Capability Like on the Halo Ballistix Z9X?

Since this model appears to join just multicoated optics, you won't get much transmittance out of the rangefinder. This makes it hard to use amid low light conditions, for example, day break and nightfall hours, particularly since the LCD readout is dark with restricted shine power settings.

How Are the Optics and Focus on This Rangefinder?

The optics on the Z9X are not too bad, yet not extraordinary. Picture clearness is great, yet that is intensely subject to climate conditions. Despite the fact that the gadget is publicized as being fogproof, light dimness and haze deleteriously affect both the rangefinder's picture quality and additionally the capacity to get an exact separation to your objective. Then again, center is speedy and smart.

How Durable Is It?

The Halo Ballistix Z9X is elastic covered, so it's stun spongy. It's likewise been O-ring fixed around the focal points, and the optics load is nitrogen-cleansed. These attributes prompt a model that is both fogproof and waterproof, and also being fit for withstanding knocks and falls without an excess of stress. Lamentably, the rangefinder just incorporates a one-year restricted guarantee.

PRODUCT HIGHLIGHTS

Class 3R Eye Safe IR LaserMaximum Range: 900 YardsPechan Prism6x Magnification23mm Objective LensAI Angle Compensation Range CorrectionMeasurements in Yards or MetersSelectable Spot and Scan ModesLiquid Crystal DisplayLow Battery IndicatorHalo® Xray® 6X Laser Rangefinders are accurate to within ONE yard!

Find out just how far that shot is with amazing precision! Halo Xray Laser Rangefinders are field-tough, precise and easy. Heck, you can even use 'em to get a little edge on your golf game when you're not ranging for wild game!

It's got your number:

AITM angle intelligence technology accounts for slope to target, giving you an accurate "shoots like" readingPrecise to +/- 1 yd.6X magnification gives you a good look at your targetScan mode allows for constant rangingRugged water-resistant constructionIncludes nylon case.1 CR2 lithium-ion batteryMax. 900-yd. range. Brown with Black rubber gripDon't guess... press and see your yardage!

Read  more :

Halo Rangefinder Reviews

[itsmedicinesfakianakis]

Differential Expression of MicroRNAs in Calcific Aortic Stenosis.

Related Articles

Differential Expression of MicroRNAs in Calcific Aortic Stenosis.

Clin Lab. 2017 Jul 01;63(7):1163-1170

Authors: Xu HX, Wang Y, Zheng DD, Wang T, Pan M, Shi JH, Zhu JH, Li XF

Abstract BACKGROUND: Calcific aortic stenosis (CAS) is the most common heart valve disorder. To explore the underlying mechanisms, we investigated whether key microRNAs in calcified aortic valves are differentially expressed compared to those in the non-calcified valves. METHODS: Calcified aortic valves from patients with aortic stenosis and non-calcified aortic valves (control) from patients with aortic insufficiency (n = 8 per group) were obtained during cardiac valve replacement surgery. The expression of miR-26a, miR-939, miR-374b*, miR-214, miR-16, miR-665, miR-130a, miR-193b, and miR-602 were evaluated by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). MiRanda and TargetScan programs were used to predict target genes, which were verified at the levels of mRNA and protein. RESULTS: The expression of osteocalcin, osteopontin, Runx2, and osterix were significantly increased in the CAS group compared with the control group. The expression of miR-26a, miR-939, and miR-374b* were significantly decreased in the CAS group compared with those in the control group (p < 0.05 and p < 0.01, respectively), and the expression of miR-214 was significantly up-regulated in the CAS group compared with that in the control group (p < 0.01). No significant differences in the expression of miR-16, miR-665, miR-130a, miR-193b, and miR602 were observed between these two groups. TWIST1 was confirmed as a target for miR-214 and expression was decreased in the CAS group compared with that in the control group. CONCLUSIONS: MiR-26a, miR-939, and miR-374b* expression was decreased and miR-214 was increased in the calcified aortic valves of CAS patients. miR-214 may promote aortic valve calcification by repressing TWIST1 expression.

PMID: 28792711 [PubMed – in process]

from #PM All via ola Kala on Inoreader http://ift.tt/2fwBecf

from OtoRhinoLaryngology - Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2wzkHsa

[epigen-papers]

Identification of Key Genes Affecting Results of Hyperthermia in Osteosarcoma Based on Integrative ChIP-Seq/TargetScan Analysis.

Pubmed: http://dlvr.it/P1nMTs

[neurogenpapers]

Long noncoding RNA FTX is upregulated in gliomas and promotes proliferation and invasion of glioma cells by negatively regulating miR-342-3p.

PubMed: Long noncoding RNA FTX is upregulated in gliomas and promotes proliferation and invasion of glioma cells by negatively regulating miR-342-3p. Lab Invest. 2017 Jan 23;: Authors: Zhang W, Bi Y, Li J, Peng F, Li H, Li C, Wang L, Ren F, Xie C, Wang P, Liang W, Wang Z, Zhu D Abstract Gliomas remain a major public health challenge, posing a high risk for brain tumor-related morbidity and mortality. However, the mechanisms that drive the development of gliomas remain largely unknown. Emerging evidence has shown that long noncoding RNAs are key factors in glioma pathogenesis. qRT-PCR analysis was used to assess the expression of FTX and miR-342-3p in the different stages of gliomas in tissues. Bioinformatics tool DIANA and TargetSCan were used to predict the targets of FTX and miR-342-3p, respectively. Pearson's correlation analysis was performed to test the correlation between the expression levels of FTX, miR-342-3p, and astrocyte-elevated gene-1 (AEG-1). To examine the role of FTX in regulating proliferation and invasion of glioma cells, specific siRNA was used to knockdown FTX, and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and transwell assays were performed. Furthermore, rescue experiments were performed to further confirm the regulation of miR-342-3p by FTX. We then found that the expression of FTX and miR-342-3p was associated with progression of gliomas. FTX directly inhibited the expression of miR-342-3p, which subsequently regulates the expression of AEG-1. Collectively, FTX is critical for proliferation and invasion of glioma cells by regulating miR-342-3p and AEG-1. Our findings indicate that FTX and miR-342-3p may serve as a biomarker of glioma diagnosis, and offer potential novel therapeutic targets of treatment of gliomas.Laboratory Investigation advance online publication, 23 January 2017; doi:10.1038/labinvest.2016.152. PMID: 28112756 [PubMed - as supplied by publisher] http://dlvr.it/NBfmd6

[cancersfakianakis1]

Emerging roles of circRNA_NEK6 targeting miR-370-3p in the proliferation and invasion of thyroid cancer via Wnt signaling pathway.

Emerging roles of circRNA_NEK6 targeting miR-370-3p in the proliferation and invasion of thyroid cancer via Wnt signaling pathway.

Cancer Biol Ther. 2018 Sep 12;:1-14

Authors: Chen F, Feng Z, Zhu J, Liu P, Yang C, Huang R, Deng Z

Abstract OBJECTIVE: To identify the significantly altered circRNAs and mRNAs in thyroid cancer, investigate their target miRNAs and determine their biological functions. METHODS: The differentially expressed circRNAs, mRNAs and pathways in thyroid cancer were identified by microarray analysis and gene set enrichment analysis (GSEA). The correlative circRNAs and mRNAs were found out through Pearson correlative analysis. The common target miRNAs of circNEK6 and FZD8 related to thyroid cancer was screened out through Targetscan, miRanda and HMDD analysis. The mRNA and protein expressions in thyroid cancer tissues and cells were detected by qRT-PCR and western blot. CircRNA was confirmed by the RNase R digestion and nucleic acid electrophoresis. The target relationships were verified by the dual luciferase reporter assay. Cell viability, invasion and apoptosis were determined by MTT assay, Transwell assay and flow cytometry, respectively. RESULTS: CircNEK6 and FZD8 were significantly up-regulated in thyroid cancer, with strong correlations. The Wnt signaling pathway was activated in thyroid cancer. MiR-370-3p was the common target miRNA of circNEK6 and FZD8, and it was down-regulated in thyroid cancer. Overexpression of circNEK6 and FZD8 could promote the growth and invasion of thyroid cancer cells, while up-regulation of miR-370-3p could suppress thyroid cancer progression and inhibit the Wnt signaling pathway. MiR-370-3p's effect on thyroid cancer cells could be rescued by circNEK6 or FZD8. CONCLUSION: CircNEK6 promoted the progression of thyroid cancer through up-regulating FZD8 and activating Wnt signaling pathway by targeting miR-370-3p.

PMID: 30207869 [PubMed - as supplied by publisher]

https://ift.tt/2xaD7RO