#Synthesis Pod

[haaaaaaaaaaaave-you-met-ted]

Synthesis Pod by Campbell White

[gotta-bail-my-quails]

hes a freak fr

[clonerightsagenda]

Scavengers Reign ep 5:

I feel like the Netflix warning for language, nudity, violence is underselling things. Do they not have warning for corpses and body horror

How would the animals who've never seen humans before know to break into the cryo pods? They shouldn't smell enticing, they're not moving, they're difficult to access.

Leaving the ship was an odd choice. Chalk it up to post-cryo disorientation I guess.

Let the fish debride your wounds is a bold strategy. Azi must be really itchy

Is Sam doing the guy bitten in a zombie movie thing. Are those glowy pods going to clone him?

Dude forgot his fucking wife when running to the escape pod. Meanwhile Azi went to check on that one girl even though she was already in stasis. Lesbians win again

Psychic baby absorbed him. What stage is this in their lifecycle... Setting up a "You're a part of it now too" good synthesis of Levi/fungus vs bad synthesis of whatever Kamen and the baby have going on

Azi is taking the whole 'your robot has gained sentience' thing pretty well

Glad Sam fessed up about the bite. But yup he's being cloned

[mthofferings2023]

oper_1895

See oper_1895’s existing works here.

Preferred contact methods: Email: oper.1895@gmail.com Tumblr: oper1895 Dreamwidth: oper-1895

Preferred organizations: - Anything from the list of approved organizations

Will create works that contain: team as family, slice of life, hurt/comfort, polyamourous relationships, queer platonic/ace-spec relationships, sexual and/or non-sexual kink (from playful kink to heavy scenes), smut, bdsm, pwp

Will not create works that contain: non-consent (consensual non-consent and certain types of dub-con are fine), scat, age play, angst, breakups, reader insert fics

  -- Fic or Other Writing --

Auction ID: 1066

Will create works for the following relationships: Bucky Barnes/Steve Rogers/Tony Stark - MCU Steve Rogers/Tony Stark - MCU Bucky Barnes/Steve Rogers - MCU Bucky Barnes/Tony Stark - MCU Bucky Barnes/Clint Barton - MCU Clint Barton/Phil Coulson - MCU Steve Rogers & Natasha Romanov - MCU Bucky Barnes/Sam Wilson - MCU James "Rhodey" Rhodes & Tony Stark - MCU Bucky Barnes & Steve Rogers & Natasha Romanov & Sam Wilson - MCU

Work Description: I’m offering classic 100 word drabbles. They can be combined into a longer fic, or completely separate (see Synthesis for an example of a fic made of drabbles: https://archiveofourown.org/works/41980641) Every $5 gets you a drabble and every $20 you have the option of getting a drabble by mail! You can choose if you want a fannish card/postcard or something related to the drabble (I’m not an artist, these will be purchased cards). You can choose to get your drabbles all at once, or scattered throughout 1 year as little treats. This may be handwritten or printed, depending on how much space I have (I want to make sure it’s legible and my handwriting is not necessarily pretty). I’ll pay for postage/postcards for up to 5 mailed items. If this goes over $100 we can discuss options and on the off chance it gets farther than that, I’m capping the official number of drabbles at 30. There’s a good chance you’ll get more, but I want to keep my promises manageable. You can be as involved as you’d like in the process, I will write most kinks and am better with kink than vanilla sex. Consider the pairing list a non-exclusive list of mix and match options. Feel free to shoot me a message if you have any questions.

Ratings: Gen, Teen, Mature, Explicit

Can pods bid on this auction? Yes - Podbids welcome!

CLICK HERE TO BID ON THIS WORK

-- Fic or Other Writing --

Auction ID: 2037

Will create works for the following relationships: Bucky Barnes/Steve Rogers/Tony Stark - MCU Steve Rogers/Tony Stark - MCU Bucky Barnes/Steve Rogers - MCU Bucky Barnes/Tony Stark - MCU Bucky Barnes/Clint Barton - MCU Clint Barton/Phil Coulson - MCU Bucky Barnes/Sam Wilson - MCU

Work Description: This auction is for at least 2K of fic. Depending on the prompt it might be longer, but I do tend towards shorter works. You can be as involved as you’d like in the process. I will write most kinks and am better with kink than vanilla sex. Consider the pairing list a non-exclusive list of mix and match options. Feel free to shoot me a message if you have any questions or if you want to confirm something specific before bidding.

Ratings: Gen, Teen, Mature, Explicit

Can pods bid on this auction? Yes - Podbids welcome!

CLICK HERE TO BID ON THIS WORK

-- Craft or Merchandise --

Auction ID: 3014

Will create works for the following relationships: Avengers fandom any gen and ship - Any Universe Captain America fandom any gen and ship - Any Universe

Work Description: This is an auction for custom table linens. The photos are examples of basic patterns and I know Avengers fandom best, but I'm open to other characters if you have the ideas. You can mix and match as much as you like or we can talk about other ideas. The values below are per item and you are welcome to pick what you want within the value of your winning bid. For example, if you win at $80 you can choose to have 4 placemats or 2 placemats and 8 napkins. Available colours are whatever I can find at the well-stocked local fabric stores. I’ll typically be working with cotton for ease of care, but if there’s something specific you have in mind that needs another fabric we can discuss. I can also make things with any Marvel themed fabric that is available to me (Examples attached, dependent on accessible inventory). Item costs: - $5 gets a single layer, single colour cotton napkin. - $20 gets a placemat with basic patterns (primarily rectangles). - If the auction goes over $100, a $50 table runner option is unlocked (approx 24 inches wide. Length and design are flexible but in general but the longer it is the less detailed it will be. Please contact me in advance if you have specific ideas/dimensions). - If the auction goes over $200, there’s the option for more complex patterns (eg, shapes that aren’t rectangles or large triangles), double sided napkins and fabric coasters ($5). I’m setting the cap at 8 place settings plus 1 table runner, but if you’re desperate for more we can chat about balancing complexity vs volume. These will be made in a non-smoking, pet-free home. Winner pays shipping from Canada. Feel free to contact me if you have any questions.

Ratings: Gen, Teen

Can pods bid on this auction? Yes - Podbids welcome!

CLICK HERE TO BID ON THIS WORK

The auction runs from October 22 (12 AM ET) to October 28 (11:59:59 PM ET). Visit marveltrumpshate.com during Auction Week to view all of our auctions and to place your bids!

[waythroughtheice]

8 and 22~

Alright!

8. How many WIP do you currently have?

Uh-oh. This'll be a list since I have a stack of WIP. I divide this into categories of "will eventually publish" and "just for me".

In the "will eventually publish", I have:

All is Quiet Chp. 17

Synthesis Reaction Chp. 6

But there is a friend (Zero's PoV of the century X was away)

The crossover stuff with Legends Reborn

Experience is the Cain of the Blind (the next part of the Robot Masters went back in time saga)

Those One Piece one shots I actually have finished but wouldn't mind publishing. Maybe.

"In the bleak midwinter", a Legend of Zelda au. Only one chapter so far, though, and I actually want to finish it before publishing it.

In the "Just for me" category we have:

A lot of Pokemon fics, like a self-insert that I have like three chapters on (I'm not publishing this because I don't think I'll ever finish it)

Stuff based on Straight Elf's Traveler, some I do publish for that discord server, others I don't. The stuff I won't publish comprises of multiple one shots based off of an au of that awesome fic. Also a crossover with One Piece, because why not.

That one Demon Slayer and MHA crossover. Some one shots are finished, others are not. The finished ones I won't publish because, again, I'll never actually finish the rest of them and I consider it unfair to do something and not commit to the end.

An AU of Linked Universe that's mixed with manwha and fire emblem sensibilities; all the Links are brothers and princes. Most are only half-brothers because their bio dad (the king) is awful. Ganondorf takes over when Time is like nine years old; this causes....issues. Ganondorf and Time have an interesting dynamic in this au since Ganondorf holds all the power, and quite a few hostages since Time's little brothers are very young. Eventually he does get kicked out when Time is 16, and more things ensue from there.

A Dark End of Hyrule, wherein Spirit (who didn't travel with the Chain) travels to a Dark Hyrule and uhhhh it doesn't go well.

A few One Piece one shots wherein Law travels back in time to Roger's time thanks to Straw Hat Shenanigans, changes somethings. Roger--who got healed by Law--ends up adopting all the D. kids, it's hilarious.

The Trenchcoat AU, wherein it's a lot of AU's masquerading as one big AU. It's a One Piece AU, wherein Garp dies when Ace and Luffy are young, so Sengoku takes 'em in. The Five Elders interfere, though, and it ends up with Luffy in a wheelchair thanks to an "illness" that only the Navy has the cure to. Ace works as a Vice Admiral to get the medicine for Luffy. There are a lot of complicated feelings with the Sengoku-Ace relationship. Luffy is Luffy and has the entirety of Marineford wrapped around his rubbery fingers.

A self-insert to One Piece, but like Roger's time. Rouge gets a whole pirate crew, and builds a city in the New World.

Iiiii think that's it?

22. Care to share any future WIP ideas you have lined up?

Uhhhhh.....this is again split into the two categories. For the publishing side of things (which is the only side I'll share)...Experience is the Cain of the Blind technically doesn't have anything written in it yet, so I think it counts.

Basically, the premise--set up from the first fic--is that Duo (the robot who sent the Robot Masters back in time) told Blues that he'd send all his family back in time, right?

And he did! It's just that what Blues didn't consider at the time--since he didn't know about X is that.....

All means all.

Cue X waking up in the pod by Dr. Cain 100 years later, completely disoriented, and after looking around at this new, strange time proceeds to go what.

(The Robot Masters didn't find the paper will, oops. Well, they will eventually but at that point Dr. Cain's already absconded with X.)

Zero and Axl are eventually found through shenanigans, and Dr. Cain is here for the ride. The Robot Masters do eventually catch up, which is even more shenanigans.

Did I mention that it's from Dr. Cain's PoV? Yeah, this entire thing will be from Dr. Cain's PoV.

Thanks for the asks!

[collapsedsquid]

King Charles reaching for the bold synthesis where we live in pods that look like Georgian cottages and eat bugs but in a fancy Victorian style I guess.

[castle-dominion]

4x23 always

Liveblog

ooh <3 always, great title!

I can't believe it has been a whole season since the shot! Good recap sequence!

Ok lmao both my father & I have fallen down mountains before. You cannot catch yourself like that, & if you do then you are probably able to swing yourself to the side to land on that balcony there. Like you can see, she pulls herself to get a better grip there!

But once one arm falls, you need to pull it back up & grab a different (non-sweaty) part of the ledge. & while yes your fingers are strong, you would do better to Bring Up Your Other Hand

Ok def sounded like castle not "man" as the captions said, then it sounded like "someone" pretending to be castle, then it sounded somewhat like castle again. (first "beckett" might have been SD told to speak like castle, could have been a different person told so. Then it was def not castle, then it was someone pretending to be castle & then the "hang on" was castle again.)

Still tho, I don't much like the unrealistic hanging scene. Actually no I really did like it & I can find reasonable excuses for the stuff I find unreasonable. It's cool.

3 days earlier

no caps. I love it.

Alexis <3 <3 <3

oh lmao she is valedictorian. I sometimes relate castle & alexis to me & my mom, but in this situation mum is alexis (smart val) & I'm castle (barely passed).

or TWILIGHT! *blinks*

RC: You know, the most worthwhile things in life are often the most difficult. For example…

*phone rings from beckett*

RC: Wow, that really is a smart phone.

btw love the golden light

KB, with a bomb cute jacket: you're probably the guy who had nothing on but boxers underneath his gown.

Me: *ran away from my graduation & climbed my way on top of a giant dumpster/storage pod*

RC: That is so insulting. If you must know, I was naked underneath.

THEY ARE GOING ON A DATE A DATE A DATE

KB: You coming, Castle?

SDFHSKJDHF I LOVE IT

Hm, two shots...

Love a shoe thing

Ooh lockpicks. Nice. I finally picked one of my locks the other day. I was using my rake tho, not my feeling peg so I would not be easily able to recreate it. I want one of those clear locks that you can see through.

Cazadores, love it when they tap the r.

Ryan is not super pretty rn

lmao poor guy down on his luck broke af, goes into the military? Sounds about right. Screw the military, this poor kid.

Captions were missing the accent on the N

Marisol? parasol? paraplui? paranormal? paralysis? analysis? synthesis? Synthwave? Literally my little brother & I went down a thought path like this. we both have adhd btw. I can't remember what thoughts came after that but we got all the way to fruit-by-the-foot.

How old is she?

I believe her.

F yeah girl. They keep blaming him & you just want to get the one who killed him.

They are so wrecking the crime scene lol.

Love how he smells the gun to see if it was fired recently ugh so good.

MONTGOMERY'S HOUSE???

Love how beckett & espt know his address but ryan looks shocked & castle (who was friends, or at least acquainted with montgomery before the show) did not know.

That was ryan not esposito who said that. This time I could tell.

Doesn't he have three kids? These pics are so weird. Roy, his wife, an older daughter, some boy... oh maybe it is a boyfriend. The baby boy would be what like 5 by now?

Girl I hope it is Not Loaded. In canada you need to have your gun locked up, though on the farm we would only lock up the bullets not the gun.

Love her.

So he knew when they were out of the house.

Btw I love espt's scar on his forehead & beckett's mole on her cheek, both give a little bit of Character to them.

Well obv this is going to be a plot heavy episode, but now is about the time I'd say it has to do with beckett not just roy & his files.

It has been like a year, or almost a year, why would you still have his old work files? nvm a year is a really short period of time

Her handwriting right now...

also I like her turtleneck.

I mean it COULD be a coincidence & it could be just for their own personal gain like maybe some rando roy put in jail & it is not actually related to johanna (in fact it makes things harder for The Big Bad Guy bc now Rando has the files)

Castle is still here, he did not leave after all <3.

She is stirring her coffee so smoothly.

KB: Say something reassuring.

RC: There are thousands of break-ins in New York City every year.

He's right: "Montgomery worked hundreds of cases. Just because this guy was after files doesn't mean he was after your mom's case."

Castle now might be the time to tell her

Green intro. Remind me to take a pic of that

Martha <3

Ooh transition! Murderboard to murderboard!

Yeah no she looks tired af.

Holding hands & they are not quite together yet but aaaah

Esposito looks nice & ryan looks incredible. Must pic this.

They blamed gangs for johanna's murder too

A MONTH after mongt was killed!?

That door really WENT. they BLEW IT UP.

Finally! They are wearing helmets!

Esposito *gets file* *face goes*

Ryan *what???? what is it?* *takes file* *face also goes*

RC: Well at least that's something. What was the crime scene?

JE: It was a shooting.

Me: ...!

their faces upon telling her, you can see how much they love her

Ryan's hands dangling there like that.

You can see ryan feeling conflicted abt this.

RC: Maybe you should be off this case.

Me: So true bestie

He brings out the first name. He loves her so much & wants her to be safe. In fact, castle has confided in him, like that time he asked ryan to keep an eye out for stuff related to johanna's murder but didn't tell becks nor espt.

(that was a weird way of pronouncing "why")

Esposito is right tho in the sense that nothing will stop her. (Except maybe castle telling her that someone forced him into a deal for her life.)

(also ryan's hair & the way he avoids eye contact)

I think I remember seeing something in the s5 bloopers but this is s4... hmm weird. I'll clip it for u tho.

No the heck you do not hold all the cards...

Who is "they"?

tbh smith is kind of unhelpful with that. I mean the rest of it was good but... idk man.

also like, they just killed another person. a thief. How many more people are they going to kill if they don't get taken down? Beckett would SO be willing to put her life in (temporary) danger to take down this ring that not only wants to kill her but also other ppl sometimes. Is her one life worth more than the lives of so many others who die because of this? They are turning a blind eye on so many things to let her live...

Interesting lighting. like the scene with alexis.

Girl he is more afraid of Them than of you.

Oh or not or he's telling her stuff

"make him whole" interesting words

Same "they"?

He KNEW he would come back to the gang & he accepted that price? Even tho he literally said he just wanted the loan? & the wife said he would not get into that?

Vincente Delgado, being poetic: Caught a glimpse before the night swallowed him whole.

KB: Yeah, but how did they know [he was desperate for money]? How do they know his background?

Me: bc they can tap into police files?

JE: Because they knew him from the military. He was hired by somebody he knew.

Me: or that

RC, trying to keep everyone safe: But whoever's gotten close to that secret is dead. I think it's clear we're in over our heads here.

JE: Speak for yourself, bro.

of course she is. If you get a mysterious $10k & don't question it & then your husband ends up dead you too would run.

Oh no the poor son!

WHAT is going ON with the lighting?

Also this room needs to be brighter than the observation room.

GIRL NO. WE ALREADY HAVE ENOUGH NATIVE KIDS IN THE FOSTER SYSTEM

Captions come on, I want to read what she said! I'm hard of hearing but I am NOT monolingual! If hearing people can understand the spanish, I WANT TO SEE THE SPANISH.

Someone military.

Getting files from the dead cop's house.

Montgomery would DEF have duplicate files hidden somewhere of the important files at least.

I love a good church. We have a native church where I live & it serves as the base church for other ethnic churches. The huge & popular italian church got its start here, the eritrean church is still in here just getting started... Plenty of good programs. It is a great church. It is one of the few churches I feel comfy going to, as a queer fnmi christowitch.

They just happen to sit near the back of the church?

& he just happens to show his face?

You can just go through the files manually.

What does cid stand for btw?

KR: How are we supposed to investigate if we can’t investigate?

My little bro while I had it paused: "I work in homicide." 'YOU KILL PEOPLE?'

Nice zoom there, love it, going into her window murderboard.

Wow a lot of shots from the past there, love it.

Oh & now we see castle doing castle investigation at home!

& we also see esposito doing investigation at night in the precinct, which kind of sucks for him, he hasn't gone home yet. (Also they haven't made his apartment set yet lol)

What is that, a pair of pliars? A razorblade?

& we don't get to see ryan investigating?

Wow he shows up at her house & esposito called her & he was ABLE TO FIGURE OUT THAT IT WAS A KEYCHAIN?

But at least it's a haystack.

He's going to tell her!

& he is not talking about mental health.

Ok so now Tell Her!

RC: Before Montgomery went into that hangar, he sent a package to someone, someone…he trusted. It contained information damaging to the person behind all this. Montgomery was trying to protect you. But the package didn’t arrive until after you’d been shot. Montgomery’s friend…struck a deal with them. If they left you alone, the package and the information inside would never see the light of day. But they made one condition—you had to back off. And that’s the reason you’re alive, Kate, because you stopped.

He's crying he loves her he really does.

Ok chill! Also he was not the one striking the deal! He was a pawn!

Yeah I thought he was behind the murder too but he could not have been bc why would he SAVE kate? maybe he is NOT saving her but he is preventing her from looking into it.

Yeah bro now is not the time to bring it up

(but I always love a "because I love you" & it is always SO good)

RC: How are you s—? Because of everything we’ve been through together! Four years I’ve been right here. Four years just waiting for you to just open your eyes, and see that I’m right here…and that I’m more than a partner. Every morning, I—I bring you a cup of coffee just so I could see a smile on your face, ((AAA <3 <3 <3)) because I think you are the most…remarkable…maddening…challenging…frustrating person I have ever met. And I love you, Kate, and if…that means anything to you, if you care about me at all, just don’t do this.

KATE NO HE WAS NOT THE ONE WHO CUT THE DEAL LIKE YOU WERE A CHILD. MONTGOMERY DID BECAUSE HE LOVES YOU LIKE HE IS YOUR FATHER. AAAAAAAGH

Actually yk what? He should have told her ages ago that someone struck a deal & she would have to back off. Except she would not have listened, just like this conversation now.

KB: Let them come. They sent Coonan, and he is dead. They sent Lockwood, and he is dead. And I am still here, Castle! And I am ready!

Ugh I had to stop my watch (which was the plan in the first place anyway) but I had the opportunity to try on my computer, I wanted to finish watching the ep & maybe post some photos that I could more easily get, but the issue is the library DVDs we have are blue ray. My computer won't play them. So yeah that's fun. I ended up doing some recording for the audiobook which I have not worked on in over a year. (About since I've been on T.)

Ok good morning I have work at 16.00 (so I need to leave before 14.45) & it is only 10 right now so I have plenty of time. But ofc I am working until midnight so that sucks pine sap. Tho I will be let off 15 minutes early so I can get home w/o breaking the law.

sdfjkfdhdsjkhhdffdkash aaaaaaah hdskjhfdska;euvn

& alexis is graduating... I cannot believe it is 2012. I mean half of 09 (s1 was short), all of 10, all of 11, & "all" of 12 (tho it has kind of only been 6m of 2012 bc she is graduating now in june)

I put my graduation tassle on my bike helmet. I rode my back to school during the warm months & I had an extra year of high school after graduating so I got to bike to school boasting that I graduated.

AC: I have watched or read every graduation address ever written and compiled all the best advice into one speech,

Me: Good idea, you overachiever

AC: and then I read it out loud. And guess what I sounded like? A pompous ass.

Me: Yeah

AC: I’m eighteen years old. What the hell do I know?

Me: You are correct, you are missing a lot more life experience than you will end up with, but you have a lot of experience now & your current speech will be relevant to the people who are here in this situation.

That's one of the reasons I stayed in high school for an extra year, I did not feel ready. I mean I also was not ready in the sense that I needed to upgrade courses but other than that I also did not feel ready on a psychological level. As an adhder my brain develops more slowly so at 18 I had the executive functions of like a 12 year old. That last year was great. I was legally an adult, I had mstured since g10, I knew the people & teachers, I was willing to accept help but I had also grown more independent, & I had gained the respect of people/staff. I was not some baby googoo gagaa, they were not robot overlords, we were people. Equals as people, though they had authority over me.

Oof fidgeting with the ring hhh

The lighting again.

They don't know what happened last night to get castle off the team & they are thinking "he would NEVER abandon beckett like that" so they know smth bad happened.

Cole Maddox.

But they looked him up so don't They know they're coming for him now?

I like how ryan is watching beckett this entire time through here, he is not looking at the driver's license he is watching beckett

Also since the tiger don't they need to tell ppl where they are going?

(also ryan's sweater is great)

Becks used to be the goody two shoes & now ryan is arguing her to go the pro way

The ether?

Wow it has been 13 years!?

First names

IDK IF YOU DO GOT THIS

"or the entire graduation" I mean like it is fine lmao

WHO from the 12th?

RYANNNN

beckett SAID he was off the team but ryan didn't believe her, he knew castle would help, like that time beckett got montgomery to kick him out & then monty still got castle back to pick her up & take her away from the hangar.

But now ryan probably thinks castle truly is NOT on the team anymore

Y'all at least wearing vests?

"get out of the way" lmao

Girl grab it & go OR un-ass the place

Oof those sexy Xs on the place

I thought they said this place was clear

Wow that was way too easy. he just Took Down both of them.

So he comes in from the front door I think. Maybe the door to the kitchen actually bc becks falls in the living room it looks like. He grabs her & smacks her against the wall, then she falls the other direction & drops her gun, which slides over to where the doorman is lying too; then esposito comes up trying to attack the guy near the door again, arms out probably trying to take a gun or maybe maddox is the one who had the gun, Madx twisted espt to the side, then looks like he maybe kneed him in the gut & threw him down to the floor too. esposito is left reeling, doesn't look unconscious.

My little bro: Savais! ("know" in french) Javier!

back to the fight scene: becks then pushes herself on the floor to grab her gun. Madx is already running away. She gets up & runs after him, then he is already running up the stairs when she shoots at him.

You can tell they had multiple sets to film this here bc suddenly they are on a roof. Lighting is fun. I'd like to hear this episode commentary by the lighting one. (Sorry, I don't watch the credits most of the time.) Well, it is also plot heavy so I'd like to hear the writer & director but shush, I want Every episode with commentary, & I want some of my fave episodes commented on by several groups. I want to hear the actors, I want to hear the writer producer & director, I want to hear the DP & lighting one & the set designer & costume designer...

Also her gun. When did she cock it & turn the safety off? I would not feel confident running like that with a loaded cocked gun like that.

She could stop for a second & shoot him... I'm sure she could make the shot.

Oh wait she does.

Look up. He probably climbed it & is going to jump you from the top.

& he probably does climb it bc he managed to get behind u.

Why does he pick her up like that? If I were him I'd use my Cool Military Training to karate chop her shoulder & knock her out.

Ooh now that was a great scene, he flips her over his shoulder & she rolls & we see it from a bird's-eye angle of destiny long shot thing? So good.

There we go he finally kicks the gun away from her, but why kick with your foot? Kicks are not useful so high, they should always be low. Chi geuk or whatever.

She is really wailing on him & he is just Fine.

Kick him in the balls hun.

lol I slowed down the video & that kick was... well. Again, don't kick the face, kick the nuts. I cannot tell if he dodges it or if he gets kicked & doesn't flinch.

Also what happened there? She goes to attack him but the camera pans down & his hand is just kind of Out & she falls?

Solar plexus? Winded her?

XD the way he just picks her up

For a sec I thought they were going to kiss

Grab her gun & shoot her? Bro come on.

The people on the street was a good choice in filming this.

(why is he just waiting there?)

(I said that out loud & lil bro said "because he's Powafull!!")

btw where is eposito? Was he knocked out there? He didn't seem unconscious. If Becks got up & came out here, surely espt (even if he was unconscious for a few seconds) could be coming up to help... UNLESS MADDOX HAS ACCOMPLICES THAT ARE KIDNAPPING OR KILLING ESPOSITO RIGHT NOW AS WE SPEAK

KB: Just tell me who’s behind this.

As if there is One person, which doubtless there is not

CM: You’re wasting your time, Detective. You have no idea what you’re up against.

KB, hot af: Neither do you.

*tries a sort of double takedown which really just fails*

& now is the start of the episode. Why doesn't he kill her tho? Long live the king mufasa style?

Oh I see. She DOES catch herself for a moment on the big ledge, making her slow enough in falling to catch herself a second time.

Like you can see she readjusts her hand! She should start side-bar-ing to the balcony to her right.

Your fingers are surprisingly strong. She is doing all this flailing & readjusting & gripping that she should totally inch her way to the right

Ooh the music

Ooh a pushzoom

Maybe growing up with parents who rock climb made me too smart.

Losing one hand might make you swing which can be dangerous but girl Bring Your Hand Back Up. Hold on with TWO hands. Unless catching absolutely ruined your tendons so you can hold on as long as it is up there but as soon as your arm fell you can't pick it up again.

She is yelling for castle not esposito who is Actually There

I already went over the voices, but this time I went over them with my little bro. Whose voice did they use when? Was it Dever trying to sound like castle?

The wedding ring!

Also y'all, if someone is falling, you do NOT have the weight to keep them up. You need to anchor yourself.

See the only reason ryan did not also fall was bc ppl were holding HIM.

Again good music

(also upon slowing it down you can see the uh.. consistency in grabbing someone falling. Have you ever done that bar trick where you get someone to catch a bill? They cannot do it. In fact, we did a similar thing in biology class. They cut & zoom in a little bit. They make ryan's sleeve into beckett's sleeve somehow.)

Castle is not here babe. It sounded like castle bc you were on the brink of death.

& gates there. She looks mad, not concerned that becks almost fell off a building

At least someone else's hand comes in there too to help her up.

& NOW beckett reaches up her other hand.

See? they have ryan & the other one down low holding up beckett & then there are also (at least) two others who are holding THEM up.

The thing is, ryan would probably be too low to pull her up, he was just holding her up. The other one helped by taking off some of the weight & pulling so that ryan could reposition himself & use his weight to pull her up.

You can see tho that she stops *there* once her elbows are on the ledge. It is hard to lift someone up. They would need to lift her up enough that she can do a pullup & get her elbows on the ledge. Then they probably grip her shoulders/upper arms to help her up while she pushes up with her arms & gets friction with her feet. Then she would roll onto the ground. & THEN she would stand up & they would be face-to-face. I would honestly like to try out smth like this (in a safe environment) to see how it works for myself rather than my logic limited experience. I want more exp.

Ryannnnnn!

(again with the lighting)

I mean yeah communication is important babes. I'm surprised she doesn't fire them.

Also esposito looks so saddddd.

VG: Don’t you “sir” me!

XD idk why I find that so funny

they don't even wear uniforms tho lol.

Girl don't resign. Don't do this you're emotional.

btw esposito in the t-shirt is great.

She looked at the badge so fondly there before resigning.

Ooooof alexis' speech over this ending? immaculate.

Wow I really feel that.

oof she looks back at the chair castle sits in hhhh

(btw they took esposito's gun but not the extra magazines he has on his belt.)

*Esposito walks angrily past Ryan and grabs his coat.*

KR, sitting on his desk after watching beckett leave & now watching esposito get going too: Javi… I had to.

*Esposito leaves without looking at Ryan.*

(& then beckett takes the elevator but not esposito??)

*Ryan throws a book across the bullpen.*

(which like...??? we often see emotion here but he yote a book. What did it hit? Where did it go?)

Ugh the rain & Her SwingsSet! I looove the swingset location in this show. I read a fic after this scene recently & it was p good. ( https://archiveofourown.org/works/3122723 )

What song is this btw?

Self is a construct. You are a person made of all the people you surround yourself with. When mum & I make the exact same noise of sympathy at the exact same time, you know she raised me. When I adopt a new word into my vocabulary from a character on a show. When I make my tea the way a past friend taught me. When my brother gets a new fidget or display of physicality...

She ends it with always instead of putting the always first shfaskjdfhsdjkfhsjhf this episode aaaaaaahhh

"in our hearts that will be with us,, always."

See? Adults are meant to play too. xbox is not just for preteen to teenaged boys.

Eeeee he puts the tassle On His Lamp!!

Don't delete it don't delete it don't delete it at least send it to her before deleting it or smth hsdjhskjdh

(at least he still has the recycling bin lol)

Knocking on the door, it has been like one minute since she called. She was probably calling to say "tell your doorman to let me in"

(fun fact, according to that set design bonus feature in new york, caskett live a 5-10min walk from one another.)

YOU

FINALLY THEY ARE KISSING WHY DID IT TAKE FOUR WHOLE SEASONS.

Sorry for what?

YOU DIDN'T CARE?

yes YES this is GREAT

& the MUSIC

& the lightning+thunder & the closing the door

& HER SCAR (but no surgery stars from when they cut her open to fix her heart lol)

Oohhhhhh it is not the end!!

Wow man looks way younger

NOOO MADDOX IS HERE IN SMITH'S PLACE AAAAH ON NO

Why is there an obsession over kate beckett? She is surely not the only enemy of Them.

& that's the end of the season!

Ok I started at 10, it is quarter to noon, it took me two hours to watch like 15 minutes of show. Holy moly.

I need to get all the clips & bonus features I want & then I'm good to send this back to the library.

[chicago-geniza]

Waiting in patient dread for my brain's unholy synthesis of the philosopher polycule and the Stefania/Jelonka correspondence (an AU where Stefania leaves Adam Pragier for Jelonka, her student/secretary, but they all live together in a queerplatonic pod)

[iwisdomplexus-blog]

The Future of Tensor Processing Units in Machine Learning

As machine learning continues to evolve, the demand for specialized hardware that can efficiently handle complex computations is more critical than ever. Tensor Processing Units (TPUs), developed by Google, have emerged as a cornerstone of modern AI infrastructure, providing unmatched performance for machine learning tasks. This blog explores the future of TPUs in machine learning, highlighting their advancements, potential applications, and the challenges they may face.

Advancements in TPU Technology

TPUs have undergone significant transformations since their inception, with each generation offering improvements in performance and efficiency. The latest iteration, TPU v5, known as Trillium, boasts over 4.7 times the compute performance per chip compared to its predecessor, TPU v4. This leap in capability allows for the training of more advanced AI models and supports the growing computational demands of generative AI applications like Google DeepMind's Gemini 1.5 Flash and Imagen 3.

Key advancements include:

Increased Power Efficiency: Each new generation of TPUs has focused on enhancing power efficiency while boosting computational capabilities. Innovations such as liquid cooling systems and optical circuit switches have been introduced to manage heat and improve data transfer rates within TPU pods .

Scalability: TPUs can be deployed in pods, allowing organizations to scale their computational resources seamlessly. This scalability is crucial for handling large datasets and complex models without requiring significant code modifications.

Integration with AI Frameworks: TPUs are increasingly compatible with popular machine learning frameworks beyond TensorFlow, including PyTorch and JAX. This flexibility allows developers to leverage TPUs across a broader range of applications 

Potential Applications

The future of TPUs is bright, with numerous applications across various sectors:

Generative AI: As generative models become more prevalent, TPUs will play a vital role in training these complex architectures efficiently. Their ability to handle large-scale computations will enable advancements in creative applications such as text generation, image synthesis, and video production.

Natural Language Processing (NLP): TPUs are already being utilized for NLP tasks that require rapid processing of vast amounts of text data. Future developments may enhance their capabilities in real-time translation and sentiment analysis.

Healthcare Innovations: In fields like genomics and drug discovery, TPUs can accelerate the analysis of large datasets, leading to faster breakthroughs in medical research and personalized medicine.

Autonomous Systems: TPUs can support the real-time processing requirements of autonomous vehicles and robotics, where quick decision-making based on sensor data is crucial.

Challenges Ahead

Despite their advantages, TPUs face several challenges that could impact their future:

Specialization Limitations: While TPUs excel at tensor operations, their specialization may limit their utility for tasks outside of machine learning or for frameworks not optimized for TPU usage This could hinder adoption among developers who prefer flexibility.

Cloud Dependency: Currently, TPUs are primarily available through Google Cloud services. Organizations looking for on-premises solutions may find this model restrictive, especially if they require localized processing capabilities.

Competition from Other Accelerators: As the landscape of AI hardware evolves, competition from other accelerators like GPUs and emerging technologies could challenge TPUs' market position. Continuous innovation will be necessary to maintain their edge .

Conclusion

The future of Tensor Processing Units in machine learning is poised for significant growth as they continue to evolve alongside advancements in AI technology. With increased performance, scalability, and integration capabilities, TPUs are set to become even more integral to the development of sophisticated AI applications across various industries. However, addressing challenges related to specialization and accessibility will be crucial for maximizing their potential.As organizations increasingly seek efficient solutions to meet their machine learning needs, TPUs will likely remain at the forefront of this technological revolution.

Are you interested in leveraging Tensor Processing Units for your machine learning projects? Explore More about Importance of the TPUs In Machine Learning

[vapehk1]

Cloaked in Style: The VOOPOO VMATE E2 Heralds a New Chapter in Vaping Elegance and Flavour

VOOPOO is thrilled to announce the launch of the VMATE E2, the latest addition to our premium VMATE vaping lineup, VMATE Family. This sophisticated device elevates the legacy of its predecessor, the VMATE E, with an exquisite blend of refined elegance and advanced functionality. The VMATE E2 appeals to discerning vaping enthusiasts with its luxurious double-sided leather finish and ingeniously designed magnetic cover, offering an unparalleled experience that seamlessly merges aesthetics with practicality. COVERED IN STYLE, DESIGNED FOR LIFE The VMATE E2's crowning feature is its meticulously crafted magnetic cap. This isn't merely an aesthetic enhancement; it's a testament to VOOPOO's dedication to preserving the integrity of the vaping experience. With a precise and satisfying closure, the cap encapsulates the mouthpiece, shielding it from dust, light, and environmental contaminants. This ensures that each inhalation remains as pure as intended. The true resilience stems from VMATE E2’s revolutionary dual-sided leather design. Unlike its predecessors, the VMATE E2 boasts a full leather wrap. This not only enhances its tactile appeal but also significantly bolsters its durability, offering robust protection against daily wear and accidental drops. Beyond its role in maintaining purity, the magnetic cap serves as a protective barrier against the rigors of daily use. It complements this rugged design, providing an extra layer of defense for the mouthpiece. . Complementing this design masterpiece is a dynamic LED strip, an intuitive visual indicator that clearly communicates the device's battery status, keeping users informed at a glance. BIG BATTERY, BIG ENJOYMENT The VMATE E2 takes pride in its large capacity battery, offering users long-lasting power and worry-free experience. This device boasts a formidable 1500 mAh battery, setting a new standard in its class, far exceeding the average capacity of similar products. Even within the VMATE product family, VMATE E2's battery capacity stands out as a top performer, providing users with unprecedented usage time. Whether it's extended video watching, gaming entertainment, or work applications, VMATE E2 proves to be a reliable and enduring companion. The VMATE E2's prowess extends beyond mere longevity. It exemplifies efficiency, capable of recharging from 0% to 100% in a mere 40 minutes. This rapid charging capability ensures that the device remains consistently ready to meet the demands of a dynamic lifestyle. 3X UPGRADE CARTRIDGE, PURE TASTE FOR EACH PUFF The VMATE Top Fill Cartridge showcases a remarkable 3X UPGRADE, delivering an unparalleled trifecta of enhancements in taste, leak resistance, and longevity. Powered by the innovative iCOSM CODE technology, it ensures a consistently pure and authentic sweet flavor that endures, making every puff as fresh and true as the first. This engineering marvel boasts impressive credentials, including a 30-day leak-free guarantee when standing and an exceptional 90 mL e-liquid capacity without coil burning, as validated by rigorous testing at Everest Lab. The cartridge's universal compatibility across the VMATE POD FAMILY further underscores VOOPOO's dedication to creating a cohesive ecosystem of high-performance vaping products, including the VMATE MAX, VMATE E2, VMATE i2, and VMATE PRO POWER EDITION. In conclusion, the VMATE E2 stands as a testament to VOOPOO's relentless pursuit of excellence in vaping technology. It transcends the conventional, offering a perfect synthesis of protective design, robust power, unmatched convenience, and flavor integrity. The VMATE E2 is tailored for those who demand the utmost in their vaping experience, representing the zenith of sophistication and performance in the industry. It promises to deliver an authentic and refined experience with every immaculate draw, setting a new benchmark for premium vaping devices. For more information and story about VOOPOO and VOOPOO VMATE Pod Family, please check the https://www.voopoo.com/ WARNING: This product contains nicotine which is a highly addictive substance. Read the full article

[ramrodd]

NT Pod 98: The Origins of Early Christian Literature: In Conversation wi...

COMMENTARY::

​ @Minimmalmythicist 5 hours ago One problem with your argument is that Genres can be quite fluid and as Walsh and others have shown, the Gospel of Mark shares characteristics with other genres, including novels of the time. Dennis Macdonald has shown beyond reasonable doubt that the Gospel of Mark is using the narrative structure of the narrative. Also that letter from Pilate is a fake. @Minimmalmythicist   wrong, Of course genres are fluid and literature contains all genre, The Post Modern Historic Deconstruction restricts the genres to the either/or paradigm of dueling dialectics of  Idealism and Materialism (not to be confused with Empiricism) The Gospel of Mark is a formal military  intelligence appreciation of what Cornelius had assembled around the testimony of Peter and John Mark in a report up his chain of command to Theophilus, who has a role more or less identical to George Smiley in John LeCarre's MI6. The autograph was in Latin, which is why the Greek translation is so coarse. The genre specific to the Gospel of Mark is Caesar's Commentaries. It's a military idiom throughout, Cornelius is the common denominator of the Gospels and Acts and the curator of the intelligence archives of the 10th Legion generally understood as Quelle. Which letter of Pilates is fake? Before I knew anything about Tertullian or the Gospel of Peter, I assumed Pilate would have reported the Resurrection, That's how the written documentation got started. The Roman soldiers had been keeping formal surveillance on John the Baptist before Jesus showed up, The demographics revealed in Mark 3:7 - 8. Cornelius calculates that approximately 30% of the Hebrew population was aligned with John the Baptist's Repentance movement before Jesus showed up and took command, The Roman soldiers called thsee Jesus Followers "Christians" because the common reference to Jesus of Nazareth, the Christ. This is conveyed to Tiberius according to Tertullian and, at that point, Tertullian is the leading edge of systematic research into Christian origins, i.e. History, An axiom of the Post Modern Historic Deconstruction is that Harmonization is the enemy of Truth, which is bullshit. Harmonization and Truth are The One,  Everything begins at the Cross, going backwards and forwards in time, Pilate's lost euangelion to Tiberius is outened in Mark 15:1 - 16:8, The literature tells us this is the first written record of Jesus as an official  response to what else was contained in that letter, which has been preserved in the oral history of the Gospel of Peter. The Talking Cross is the subject of the report to Tiberius regarding the endorsement of the Jewish god of the Italian Regiment as an expression of Romans 13:1 - 7 and N/T. Wright's interpretation of Pauline Theology,  This is what is available with the dialectical synthesis of Hegel's Phenomenology of Spirt and the Historic Gestalt. The Post Modern Historic Deconstruction of the JEsus Seminar and the Pro-Life Solo Scriptura Calvinism excludes all those genres  in order to control the narrative, Which offends me

[xasha777]

In the year 2801, humanity had long transcended the boundaries of the old Earth, forging empires among the stars. Yet, Earth remained a living museum, a cradle of history and a sanctuary where the echoes of the past were preserved. The Siege of Barcelona in 801, a distant yet pivotal event, was celebrated annually through a sophisticated virtual reality experience that brought participants back to the very heart of the battle.

Ela was a descendant of that ancient city, her lineage as proud as it was long. She was an ethereal synthesis of her ancestors and the cutting-edge technology that had become inseparable from human life. With feline features engineered for elegance and enhanced perception, she embodied the next step in evolution.

As Barcelona prepared for the millennial celebration of its siege, Ela volunteered to participate in the most immersive reenactment yet. The city's AI, an entity as old as the stars, was tasked with creating a virtual battleground so realistic it would transport the consciousness of participants back a thousand years.

When the day arrived, Ela lay in the neural-sync pod, her bioluminescent eyes reflecting the flicker of holographic scenes playing before her. She was not just a spectator; she became an avatar within the simulation, experiencing the emotions, turmoil, and adrenaline of the historical defenders.

But as the virtual siege unfolded, Ela encountered an anomaly—a figure that should not have been part of the scripted past, an enigmatic warrior whose eyes mirrored the cosmos itself. This warrior spoke not of the siege but of a greater war that spanned time and space—a war against a darkness that threatened to engulf worlds in different dimensions.

Ela, intrigued and compelled, found herself drawn to the warrior's cause. As the siege reached its climax, with the city walls trembling under the assault of virtual invaders, the warrior offered Ela a choice: return to her reality or join the eternal fight to safeguard the threads of existence.

The decision weighed heavy on her, for it defied the very purpose of her participation—to honor the past, not to escape it. But the allure of a battle greater than any historical reenactment, a battle that transcended the limitations of virtual simulations and historical importance, called to her.

With the sounds of the siege fading into silence, Ela made her choice. She reached out to the warrior, her hand phasing through the holographic enemies as if they were ghosts of time. The simulation around her dissolved into stardust, revealing a bridge of light that connected her mind to a nexus of realities.

Ela stepped forward, leaving behind the echoes of ancient Barcelona, stepping into a war woven into the fabric of the multiverse. Her journey would become a legend, spoken of in hushed tones by future historians who marveled at the Siege of Barcelona and the girl who chose to become a guardian of time itself.

[coherentmarketinsights]

Navigating Supply-Demand Dynamics in the Potash Fertilizers Market

Potash Fertilizers:  Exploring the Vital Role in Agriculture and its Influence on Food Production

What is Potash?

Potash refers to various mined and manufactured salts that contain potassium in water-soluble form. Potassium is one of the three primary macronutrients used in fertilizers, along with nitrogen and phosphorus. Potash exists both as minerals and salts, with the most common being potassium chloride, otherwise known as muriate of potash. It is predominantly used as a fertilizer for agriculture. Role of Potassium in Plant Growth

Plants require potassium to perform important functions in their growth cycle. Potassium regulates processes like photosynthesis, translocation of sugars, enzyme activation and protein synthesis within plants. It improves the ability of plants to absorb and retain nutrients efficiently, making them more resilient to stresses caused by drought, disease or frosts. Adequate potassium levels promote robust root development, strengthening the overall structure of plants. Key Crops Benefitted by Potash Application

Potassium is especially important for high-yielding crops like cereals, fruits and vegetables. Some crops that benefit significantly from potash fertilization include: Maize - Maize benefits tremendously from potash as it promotes stalk strength and drought tolerance in the crop. Potash application leads to higher yields of maize grains in many regions. Wheat - Potassium maximizes the production of carbohydrates in wheat plants, boosting grain filling and yields. It improves grain size, protein content and milling qualities. Rice - Potash application enhances panicle formation and grain development in rice. It enables rice crops to withstand biotic and abiotic stresses better. Soybean - Potassium greatly influences nodule formation and nitrogen fixation in soybean plants. This leads to improved pod formation, seed quality and higher oil content in soybean. Vegetables -Leafy greens and root vegetables like tomatoes, potatoes and carrots absorb more potassium than other macro nutrients. Potash fertilizers are crucial for their growth, quality and shelf-life. Role in Improving Food Security Global population is expected to rise to nearly 10 billion by 2050, placing enormous pressure on the agricultural sector to increase food production substantially. The plant-available forms of potash from fertilizers play a critical role in boosting yields to meet escalating food demand. Research shows potash application led to yield gains ranging from 10% for wheat to 67% for potatoes in different regions. By bridging existing crop yield gaps, potash fertilizers can potentially increase overall global food output by 278 million tons according to studies. This mitigates food insecurity issues and eases supply chain constraints caused by geopolitical tensions. Importance of Maintaining Soil Potassium Levels Soil testing and balanced fertilization practice are vital to maintain adequate potassium levels in cultivable land. Continuous cropping and exhaustive crop harvesting deplete soil potassium over time if not replenished through fertilizers. Low potassium levels impair crop vigor and render plants susceptible to diseases and environmental stresses. This impacts both yield and quality negatively. Maintaining a minimum recommended potassium level based on soil type is advisable to sustain long-term productivity and profitability of farms. Balanced potash nutrition also helps to optimize usage of other agro inputs for maximizing returns on investment. Furthermore, potassium recycling with crop residues sustains a balanced nutrient budget in the soil. Concerns over Potash Supply and Price Volatility Top potash producing countries are located in politically sensitive regions and production is dominated by a few large companies and state-owned enterprises. Geopolitical tensions or changes in export policies have previously led to significant supply disruptions and price spikes in the global potash market. Nearly two-thirds of global potash reserves are situated in Canada and Russia alone. Potassium chloride reserves in other major producers like Belarus, Germany and Israel will only last for a few more decades at current production rates. Mounting global fertilizer demand has increased dependency on supplies from regions like Canada with large unexploited reserves that are also environmentally challenging and capital intensive to tap. This supply insecurity coupled with monopoly pricing power of select producers makes long term potash access an uncertainty for many importing countries dependent on international trade. Food security concerns arise from unreliable potash availability and price volatility caused by such supply constraints.

[tylerhellard]

Pop Loser Vol. 1 No. 9

☆

Pod Loser. / Love, a mixtape. (I’m gonna make more of these. Here’s the podcast feed.)

The continuing march of something or other. / 📖 The fight over OpenLibrary. ❝This was the dream of the internet I believed in. The internet as a global brain. A universal encyclopedia.❞ / Sorta related: 🎞️ There’s a copy of Swayze’s secret shame, Skatetown, USA, on the Internet Archive. / 🧑‍🎤 Looking back at “We Are the World”—the weirdest night in pop—through the new doc. ❝Listening to its mild wash of melody and sentiment can produce an odd mix of grudging respect and self-flagellation; it feels bad to disdain a charity single.❞ / From the New Yorker archive: Susan Orlean’s 1991 profile of Fab Five Freddy. ❝Summing up what he does for a living, Freddy said recently, ‘I’m the king of synthesis.’ There is no such job listed with the United States Bureau of Labor Statistics. Freddy nonetheless synthesizes full time.❞ / 🤖 The luddites are coming. ❝Eliezer Yudkowsky explains with real patience that every single person we know and love will soon be dead. They will be murdered by rebellious self-aware machines.❞ / 🏖️ The Dune font.

⇩

⇨

[omkarpatel]

Thebaine: Nature's Gift or a Double-Edged Sword

Thebaine is an important organic compound that occurs naturally in some species of poppy plants. While it has legitimate medical uses, it also has properties that make it highly vulnerable for misuse and diversion into the illegal drug market. This article explores the history, properties, uses as well as challenges associated with thebaine. Properties and Occurrence Thebaine is an opioid alkaloid that is found in trace amounts within the unripe seed pods of select poppy varieties, including Papaver bracteatum and Papaver somniferum. It constitutes less than 3% of the total alkaloid content of these plants. Structurally, thebaine is similar to both codeine and oxycodone but has an unusual pharmacological profile that sets it apart. Its unique properties arise from a linkage that exposes tertiary amine and phenolic hydroxide functional groups. The presence of the tertiary amine makes it weakly psychoactive but highly susceptible to conversion into potent opioids. Medical Uses Despite its weak intrinsic activity, thebaine serves as an essential starting material in the semi-synthesis of many potent opioids used medically today. Through acetylation and demethylation, thebaine can be converted into hydrocodone, oxycodone, oxymorphone and nalbuphine. These opioids play important roles as painkillers and cough suppressants used to treat moderate to severe pain as well as breathing difficulties. Without thebaine as an intermediate, it would be nearly impossible to manufacture these drugs through isolation from natural sources alone. Challenges and Risks While thebaine facilitates the production of important medications, its unique properties also render it prone to misuse and diversion for illicit drug manufacture. Firstly, thebaine in its pure form holds little therapeutic value due to its weak opioid effects. This raises the potential for recreational experimentation and abuse. More significantly however, thebaine can be readily converted into highly addictive and dangerous opioids like heroin through facile chemical reductions. The conversion process can be carried out relatively easily with rudimentary equipment and reagents outside regulated facilities, allowing for widespread potential for abuse. Several clandestine laboratories disguised as legitimate pharmaceutical operations have been uncovered attempting to synthesise heroin from diverted thebaine. This underscores the compound's status as a controlled substance vulnerable to exploitation for illicit drug production if not closely monitored and regulated. Regulation and Supply Chain Integrity Given thebaine's dual-use potential, strict controls have been instituted worldwide to prevent diversion and abuse while still allowing its use in licensed medical applications. In the United States, thebaine is classified as a Schedule II controlled substance under the Controlled Substances Act, indicative of its high potential for addiction and approved medical use. Its international trade is regulated through bilateral quotas negotiated between producing and importing countries according to the Single Convention on Narcotic Drugs. Additionally, companies engaged in thebaine extraction, production and formulation are subject to rigorous oversight, record-keeping, security and auditing requirements. Secure supply chains from licensed poppy farmers to drug product manufacturers aim to eliminate opportunities for criminal diversion and misappropriation. However, the profitable illicit heroin market continues to pose challenges, meaning vigilance must remain steadfast.

[rnomics]

IJMS, Vol. 24, Pages 5809: SCL14 Inhibits the Functions of the NAC043–MYB61 Signaling Cascade to Reduce the Lignin Content in Autotetraploid Populus hopeiensis

Whole-genome duplication often results in a reduction in the lignin content in autopolyploid plants compared with their diploid counterparts. However, the regulatory mechanism underlying variation in the lignin content in autopolyploid plants remains unclear. Here, we characterize the molecular regulatory mechanism underlying variation in the lignin content after the doubling of homologous chromosomes in Populus hopeiensis. The results showed that the lignin content of autotetraploid stems was significantly lower than that of its isogenic diploid progenitor throughout development. Thirty-six differentially expressed genes involved in lignin biosynthesis were identified and characterized by #RNA sequencing analysis. The expression of lignin monomer synthase genes, such as PAL, COMT, HCT, and POD, was significantly down-regulated in tetraploids compared with diploids. Moreover, 32 transcription factors, including MYB61, NAC043, and SCL14, were found to be involved in the regulatory network of lignin biosynthesis through weighted gene co-expression network analysis. We inferred that SCL14, a key repressor encoding the DELLA protein GAI in the gibberellin (GA) signaling pathway, might inhibit the NAC043&ndash;MYB61 signaling functions cascade in lignin biosynthesis, which results in a reduction in the lignin content. Our findings reveal a conserved mechanism in which GA regulates lignin synthesis after whole-genome duplication; these results have implications for manipulating lignin production. https://www.mdpi.com/1422-0067/24/6/5809?utm_source=dlvr.it&utm_medium=tumblr