#Surgical Sealant And Adhesives

[healthcareporium]

Unveiling the Potential of Biosurgery: Market Analysis and Innovation

What is Biosurgery?Biosurgery, a rapidly evolving field in healthcare, is gaining prominence as a pioneering approach in various medical procedures. It involves the use of specialized biological materials and techniques to aid the healing and sealing of wounds, control bleeding, and promote tissue regeneration. In this blog, we delve into the biosurgery market, exploring the key product types and…

[analyticalmarketresearch]

Global Surgical Sealants and Adhesives Market ,Size, Industry Analysis, Market Shares, Cost Structures and Forecasts to 2030

Global Surgical Sealants and Adhesives Market

Global Surgical Sealants and Adhesives Market was valued at USD 2.54 billion in 2019 which is expected to reach USD 6.13 billion in 2030 at a CAGR 9.5%.

Surgical sealants and adhesives are useful to repair injured tissues, and surgical wounds.  These materials are most frequently used to achieve mechanical hemostasis in vascular reconstruction. Adhesives and sealants are widely preferred materials due to its advantages such as efficacy, safety, and usability in repairing injured tissues.

Read More Here: https://qualiketresearch.com/reports-details/Surgical-Sealants-and-Adhesives-Market

Key Players:

Various key companies are profiled in this report such as Baxter International, Inc. ,  Tissuemed Ltd, Hemostasis, LLC, B. Braun Melsungen AG, GEM Srl, CSL Limited, MicroVal, Johnson and Johnson, Vivostat A/S, Integra Lifesciences Holding Corporation, Medline Industries, Inc.,and Becton, Dickinson, and Company

Market Restraints

Increase in healthcare cost and lack of reimbursement are major restraints which expected to hamper the global surgical sealants and adhesives market growth. Also, cost-intensive requirement of clinical data for new product launches will limit the global surgical sealants and adhesives market growth.

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[meditechinsight01]

Global Biosurgery Market: The Integration of Stem Cell Therapy in Surgical Treatments and Its Growth by 2030

The global biosurgery market is projected to grow at a CAGR of 5% from 2025 to 2030. This growth is driven by the increasing prevalence of chronic conditions necessitating surgical interventions, advancements in biosurgical technologies, and rising demand for minimally invasive procedures. Biosurgery products play a vital role in reducing surgical complications, enhancing wound healing, and improving patient outcomes.

Biosurgery encompasses a range of products, including hemostatic agents, adhesion barriers, and sealants, designed to optimize surgical outcomes. These products are essential in controlling bleeding, preventing adhesion formation, and sealing tissues during surgical procedures. The market’s growth is primarily fueled by technological advancements in biosurgery products, increasing adoption of minimally invasive surgeries, and growing healthcare expenditure worldwide.

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Growing Prevalence of Chronic Diseases Driving Biosurgery Market Growth

The rising prevalence of chronic diseases, such as cardiovascular disorders, orthopedic conditions, and diabetes, is significantly boosting the demand for biosurgery products. These conditions often require complex surgical interventions, which necessitate the use of advanced biosurgery solutions like hemostatic agents, adhesion barriers, and surgical sealants to manage bleeding, minimize complications, and improve surgical outcomes. For instance, patients with diabetes are at higher risk of impaired wound healing, increasing the demand for biosurgery products that promote tissue repair and regeneration. Additionally, the aging global population, which is more susceptible to chronic illnesses and associated surgeries, further propels the market. Biosurgery innovations are increasingly tailored to address these challenges, improving procedural efficiency, and enhancing patient recovery, thereby positioning the market for robust growth in the coming years.

Rising Innovations in Biosurgery for Cost-Effective and Efficient Surgical Outcomes

The growing adoption of innovative biosurgery products is significantly driving market growth, especially in addressing complications from complex surgeries. For instance, Integra LifeSciences’ DuraSeal dural sealant has recently demonstrated substantial healthcare cost savings in preventing cerebrospinal fluid leaks during posterior cranial fossa surgeries. A study across 5 European countries highlighted that DuraSeal reduced procedural costs by 15–22% compared to fibrin glue, showcasing its clinical and economic benefits (Source: Journal of Comparative Effectiveness Research). Similarly, advancements in PEG hydrogel technologies and adhesive barriers are increasingly favored for reducing surgical complications and hospital readmissions. Companies like Baxter International and Ethicon continue to develop advanced hemostats and sealants, offering enhanced precision in controlling bleeding and tissue adhesion during surgeries. Such innovations cater to the rising surgical volume driven by chronic diseases and aging populations, cementing biosurgery products as indispensable tools for improving patient outcomes while optimizing healthcare expenditure.

Competitive Landscape Analysis

Leading players in the biosurgery market, including Baxter International, Johnson & Johnson (Ethicon), Medtronic, Becton, Dickinson and Company, and Integra LifeSciences, are focusing on acquisitions, product innovations, and strategic partnerships, to strengthen their market position. These companies are investing in R&D to develop novel biosurgical products and expand their global footprint.

Unlock key findings! Fill out a quick inquiry to access a sample report https://meditechinsights.com/biosurgery-market/request-sample/

Global Biosurgery Market Segmentation

This report by Medi-Tech Insights provides the size of the global biosurgery market at the regional- and country-level from 2023 to 2030. The report further segments the market based on product, application, and end user.

Market Size & Forecast (2023-2030), By Product, USD Billion

Bone-Graft Substitutes

Demineralized Bone Matrix

Synthetic Bone Grafts

Others

Soft-Tissue Attachments

Synthetic Meshes

Biological Meshes

Hemostatic Agents

Surgical Sealants & Adhesives

Natural/Biological Sealants & Adhesives

Synthetic and Semi-Synthetic Sealants & Adhesives

Adhesion Barriers

Synthetic Adhesion Barriers

Natural Adhesion Barriers

Others

Market Size & Forecast (2023-2030), By Application, USD Billion

General Surgery

Cardiovascular Surgery

Orthopedic Surgery

Neurosurgery

Reconstructive Surgery

Gynecological Surgery

Urology Surgery

Thoracic Surgery

Other Applications

Market Size & Forecast (2023-2030), By End User, USD Billion

Hospitals

Physician Practices

Ambulatory Surgical Centers

Others

Market Size & Forecast (2023-2030), By Region, USD Billion

North America

US

Canada

Europe

Germany

France

UK

Italy

Spain

Rest of Europe

Asia Pacific

China

India

Japan

Rest of Asia Pacific

Latin America

Middle East & Africa

About Medi-Tech Insights

Medi-Tech Insights is a healthcare-focused business research & insights firm. Our clients include Fortune 500 companies, blue-chip investors & hyper-growth start-ups. We have completed 100+ projects in Digital Health, Healthcare IT, Medical Technology, Medical Devices & Pharma Services in the areas of market assessments, due diligence, competitive intelligence, market sizing and forecasting, pricing analysis & go-to-market strategy. Our methodology includes rigorous secondary research combined with deep-dive interviews with industry-leading CXO, VPs, and key demand/supply side decision-makers.

Contact:

Ruta Halde  Associate, Medi-Tech Insights  +32 498 86 80 79  info@meditechinsights.com 

[anziambio]

Anziam Bio: Leading Innovations in Bleeding Control Solutions and Advanced Wound Care

Effective bleeding control solutions and advanced wound care are critical for improving patient outcomes, reducing complications, and saving lives. Whether in surgical settings, trauma care, or chronic wound management, innovative biotechnology plays a crucial role in accelerating healing and preventing excessive blood loss. Anziam Bio, a pioneering biotech company, is at the forefront of revolutionizing wound care with state-of-the-art bleeding control technologies and bioengineered healing solutions.

The Growing Need for Advanced Wound Care and Bleeding Control

Uncontrolled bleeding and chronic wounds present major challenges in modern healthcare. Effective treatment is essential due to:

Increased Surgical Procedures: More surgeries mean a higher demand for reliable hemostatic agents and wound care products.

Rising Trauma Cases: Accidents, military injuries, and emergency situations require rapid and efficient bleeding control solutions.

Chronic Wound Burden: Diabetic ulcers, pressure sores, and non-healing wounds need advanced wound care for successful recovery.

Infection Prevention Needs: The risk of wound infections necessitates antimicrobial and bioactive wound care solutions.

Anziam Bio’s Cutting-Edge Bleeding Control Solutions

Anziam Bio is committed to developing highly effective bleeding control products that provide rapid hemostasis and improve clinical outcomes. Our portfolio includes:

1. Hemostatic Dressings and Sponges

Rapid-Clotting Hemostatic Sponges: Designed for surgical and trauma settings to stop bleeding instantly.

Antimicrobial-Infused Dressings: Prevent infections while promoting faster clot formation.

Super Absorbent Wound Dressings: Capable of managing heavy exudate and stabilizing wounds effectively.

2. Surgical Hemostasis Solutions

Biodegradable Hemostatic Agents: Dissolvable solutions that enhance natural clotting without requiring removal.

Surgical Sealants and Tissue Adhesives: Used for precise control of post-operative bleeding.

Hemostatic Gel Formulations: Ideal for complex procedures requiring enhanced coagulation support.

3. Emergency and Trauma Hemorrhage Management

Advanced Battlefield and First Responder Dressings: Military-grade wound care solutions for severe bleeding.

Pre-Hospital Hemorrhage Control Kits: Designed for paramedics and trauma specialists for quick intervention.

Injectable Clotting Agents: Bioengineered solutions for internal hemorrhage management.

Advanced Wound Care Innovations by Anziam Bio

Beyond bleeding control, wound healing acceleration is crucial for recovery and preventing long-term complications. Anziam Bio offers advanced wound care products that integrate biotechnology with regenerative medicine.

1. Bioactive Wound Healing Dressings

Growth Factor-Infused Wound Dressings: Stimulate cell regeneration for faster tissue repair.

Hydrogel and Hydrocolloid Dressings: Maintain moisture balance for optimal healing.

Antibacterial Silver Nanoparticle Dressings: Combat infections and accelerate wound closure.

2. Chronic and Non-Healing Wound Solutions

Regenerative Wound Therapy: Promoting new tissue growth for diabetic ulcers and pressure sores.

Collagen-Based Healing Patches: Designed to support chronic wound management and enhance natural healing.

Oxygen-Boosting Dressings: Improve oxygenation in wounds, aiding in faster recovery.

3. Post-Surgical Wound Management

Hemostatic Wound Closure Strips: Offering an alternative to traditional sutures with reduced scarring.

Smart Wound Monitoring Solutions: Integrating biosensors for real-time infection detection.

Hybrid Regenerative Bandages: Combining clotting agents with tissue repair technology.

Clinical Validation and Scientific Excellence

Anziam Bio’s bleeding control and wound care solutions are backed by rigorous clinical trials and scientific research. Our commitment to excellence ensures:

Faster Clotting Time: Proven to stop bleeding up to 50% faster than conventional methods.

Biocompatible and Safe Materials: Designed to work naturally with human physiology.

Reduced Infection Risks: Enhanced antimicrobial properties for safer wound healing.

Regulatory Compliance: Meeting international healthcare safety standards for global adoption.

The Future of Bleeding Control and Wound Care

Anziam Bio continues to push the boundaries of biotechnology-driven medical advancements. Future innovations include:

Smart Hemostatic Materials: Integrating nanotechnology for intelligent clot activation.

AI-Powered Wound Healing Monitoring: Real-time analysis for predicting healing progress.

Personalized Hemostatic Therapies: Tailored bleeding control solutions for specific patient conditions.

Conclusion

Anziam Bio is redefining bleeding control solutions and advanced wound care with its biotech-driven approach. By combining research-backed hemostatic technologies with regenerative wound healing strategies, we provide clinically proven, life-saving solutions for patients, surgeons, emergency responders, and chronic wound sufferers. As we continue to innovate, our mission remains clear—enhancing medical outcomes, improving patient recovery, and leading the future of biotechnology in healthcare.

[globalinsightblog]

European Hemostats & Sealants Market: $3.5B in 2023 to $6.0B by 2033, 5.2% CAGR

European Hemostats & Sealants Market is expanding rapidly, driven by technological advancements and increasing awareness of blood loss management in surgical settings. Hemostatic agents and sealants, crucial in controlling bleeding and promoting tissue adhesion, play an integral role in improving surgical outcomes, reducing operative time, and minimizing complications. With applications spanning cardiovascular, orthopedic, neurosurgery, and more, these products are becoming indispensable in various medical procedures across Europe.

To Request Sample Report : https://www.globalinsightservices.com/request-sample/?id=GIS24899 &utm_source=SnehaPatil&utm_medium=Article

A major growth driver for the market is the surge in surgical procedures and the rising demand for more efficient solutions to enhance patient safety. The hemostats segment, led by thrombin-based products, dominates the market, accounting for a significant share due to their high efficacy in controlling bleeding. Fibrin sealants are the second-most popular choice, thanks to their biocompatibility and effectiveness in tissue adhesion. These innovations are set to revolutionize surgical care, particularly in specialized fields like cardiovascular and orthopedic surgeries.

Geographically, Germany leads the European market, owing to its advanced healthcare infrastructure and high surgical procedure volume. The United Kingdom follows closely, with strong investments in healthcare driving growth. Southern Europe, particularly Italy and Spain, is also seeing an uptick in demand, supported by the rising prevalence of chronic diseases and improved healthcare spending.

Key players, including Baxter International, Johnson & Johnson, and B. Braun Melsungen AG, are at the forefront, leveraging their technological capabilities to advance product offerings and expand into new application areas. These companies are focusing on both R&D and strategic partnerships to stay competitive in a rapidly evolving market.

Looking ahead, the European Hemostats & Sealants Market is expected to continue its upward trajectory, with a forecasted increase from 120 million units in 2023 to 180 million by 2033. The integration of AI in surgical applications and ongoing innovation in bio-based hemostats and sealants promise further growth, presenting substantial opportunities for stakeholders. However, the market must navigate challenges such as regulatory compliance and price pressures, which are likely to shape future market dynamics.

In conclusion, the European Hemostats & Sealants Market is poised for substantial growth, driven by technological advancements, rising healthcare demands, and increased focus on patient safety.

#EuropeanHealthcare #Hemostats #SurgicalInnovation #SealantsMarket #MedicalTechnology #BloodLossManagement #SurgicalCare #ThrombinProducts #FibrinSealants #AIInHealthcare #CardiovascularSurgery #OrthopedicSurgery #PatientSafety #SurgicalAdvancements #HealthcareGrowth

[global-research-report]

Chronic Wound Care Industry Analysis: Key Drivers, Challenges, and Strategic Opportunities

The global chronic wound care market size is expected to reach a value of USD 17.6 billion by 2030, according to a new report by Grand View Research, Inc. It is projected to register a CAGR of 4.07% from 2023 to 2030. Diabetes may increase the overall frequency and complexity of wounds such as infections, ulcerations (leg or foot ulcers), and chronic wounds, including surgical & traumatic wounds. For instance, according to a research article published in March 2021 by ScienceDirect, the prevalence of diabetes is expected to increase to 120 million people in 2030, thereby propelling market growth.

The outbreak of COVID-19 has created large-scale opportunities for local manufacturers. Due to the restrictions on movement at international borders, the supply chain of major players has been disrupted. This has created an opportunity for local players to enter the market and meet the unmet demands of the end-users. The rising number of cases has led to a shortage of medical supplies; thus, local players are manufacturing products on a larger scale to meet the growing need. Moreover, to enhance their foothold in the market, key companies are adopting various plans and policies to gain a higher market share.

Technological advancements are projected to have a significant impact on the advanced wound care industry in the coming years. The quality of life of patients suffering from chronic wounds improves as technology advances and becomes more affordable. Traditional wound care and closure products are gradually being replaced by advanced wound care & closure products due to their efficacy and effectiveness in wound management by allowing quicker healing.

Chronic Wound Care Market Report Highlights

Advanced wound dressing was identified as the highest revenue-generating segment in 2022 due to its major usage in the treatment of chronic and non-healing wounds

In 2022, foam dressing was the highest revenue-generating advanced wound dressings sub-segment as this dressing absorbs moisture that aids in maintaining the integrity of the tissue

The hospitals segment held the largest revenue share amongst various end-use channels in 2022, owing to increasing footfall. Also, surgical wound care dressings and NPWT are predominantly suitable for treatment in hospital

North America held the largest revenue share in the market in 2022 due to the availability of skilled professionals and improvement in healthcare infrastructure

Chronic Wound Care Market Segmentation   

Grand View Research has segmented the global chronic wound care market based on product, application, end-use, and region:

Chronic Wound Care Product Outlook (Revenue, USD Million, 2018 - 2030)

Advanced Wound Dressing

Foam Dressing

Hydrocolloid Dressing

Film Dressing

Alginate Dressing

Hydrogel Dressing

Collagen Dressing

Other Dressing

Surgical Wound Care

Suture & Staples

Tissue Adhesive & Sealants

Anti-infective Dressing

Traditional Wound Care

Medical Tapes

Cleansing Agents

Others

Wound Therapy Devices

Negative Pressure Wound Therapy

Oxygen and Hyperbaric Oxygen Equipment

Electric Stimulation Devices

Pressure Relief Devices

Others

Chronic Wound Care Application Outlook (Revenue, USD Million, 2018 - 2030)

Diabetic Foot Ulcers

Pressure Ulcers

Venous Leg Ulcers

Others

Chronic Wound Care End-use Outlook (Revenue, USD Million, 2018 - 2030)

Hospitals

Specialty Clinics

Home Healthcare

Others

Chronic Wound Care Regional Outlook (Revenue, USD Million, 2018 - 2030)

North America

US

Canada

Europe

Germany

UK

France

Italy

Spain

Asia Pacific

Japan

China

India

South Korea

Australia

Latin America

Brazil

Mexico

Argentina

Colombia

MEA

South Africa

Saudi Arabia

UAE

Order a free sample PDF of the Chronic Wound Care Market Intelligence Study, published by Grand View Research.

[yadavsatveer]

Mens hair pieces - Get Hair pieces for Men

There was a previous time when Mens hair pieces were used as a fashion statement. The more accurate, the better. Men wear wigs with pride. But styles change over time and men are no longer interested in that and prefer to keep their hair natural. Nowadays, there are men's Hair pieces available for men to wear, and no one will notice that they look unnatural.

They are processed to aspect as naturally as probable. They can be made of synthetic fibers or 100% artificial fibers. Human hair is normally of the uppermost quality and lasts longer than synthetic hair. Hair replacement systems, commonly called wigs or Hair pieces, are worn by professionals for long periods. Men's hair pieces are a go-to for men and women who don't want to take hair loss medications or undergo surgery. Toupées are one of the coolest and oldest solutions to hair loss and hide baldness.

Mens hair direct- Easy to Wear

Men's Hair pieces are not just wigs. There are now men's hair direct available near me that can be worn by men, too. Wigs can be worn by bald men or men with thin hair. Men with thin hair can also wear extensions to make their hair look thicker and fuller. Hair pieces are the easiest to wear, remove, and maintain. Other things need to be integrated with the hair. The most common way to attach a hair direct is by glueing. There are many adhesives used today. Oil is applied and heated to remove the strands.

The heat melts the adhesive, making it easier for the oil to flow into the hair. In addition, more expensive sealants do not require heating or oiling to remove the Hair piece. A release agent is applied, which dries the adhesive into a powder. It falls off when washed. Luckily, Hair pieces around me have come a long way overall. These Hair pieces are the most preferred option for patients undergoing drug treatments such as chemotherapy (when surgical treatment is not possible).

 Get natural Hair pieces from Hairpiece Warehouse

 Some of the most expensive hair systems do not rely on synthetic fibers and use natural human hair. Moreover, regardless of the cost, most people buy two hair systems: one that is wearable and one that is cleaned and restored. However, each person has their preferences, so different types of Hair pieces will meet everyone's needs. If you do not use a wig every day, you do not need two Hair pieces. When buying the best Hair pieces from Hairpiece Warehouse, the hair replacement should "fit" your hair system. To achieve a more natural look, it should be the right size to fit your head and face.

Also Read What to Know About hair systems for men Before Buying One.

[aegislifescience]

Revolutionizing Liver Surgery: The Crucial Role of Oxidized Regenerated Cellulose Gauze in Bleeding Management

In the realm of hepatic surgeries, controlling intraoperative bleeding is a critical challenge. Despite significant advancements in surgical techniques and perioperative care, managing bleeding effectively remains a paramount concern. Intraoperative bleeding can lead to numerous complications, including the need for additional interventions, extended hospital stays, increased healthcare costs, and, in severe cases, even mortality. Effective hemostatic strategies are essential for optimizing surgical outcomes and patient safety [1].

Oxidized regenerated cellulose gauze (ORCG) has emerged as a vital tool in the management of surgical bleeding. This blog delves into the pivotal role of ORCG in liver surgeries, exploring its applications, benefits, and future directions in the field of hemostatic agents.

Surgical Techniques for Managing Bleeding

Surgeons employ various techniques to manage bleeding during liver surgeries:

Vascular Clamping: Temporarily stopping blood flow to the liver using techniques like the Pringle Maneuver, which clamps the hepatic artery and portal vein, or Total Vascular Occlusion, which stops blood flow by clamping both inflow and outflow vessels.

Dissection Devices for Transection of Liver Parenchyma: Using both classic methods, such as scalpels and the finger-fracture technique, and advanced methods, including the Cavitron Ultrasonic Surgical Aspirator (CUSA), Hydro-Jet, and radiofrequency ablation devices. Each method has its advantages for cutting liver tissue precisely while minimizing bleeding.

Low Central Venous Pressure (CVP): Reducing CVP helps minimize bleeding by decreasing the pressure within blood vessels. This can be achieved through volume contraction, phlebotomy, and the use of vasodilating agents [2].

While these techniques have made significant strides, sometimes they’re not enough. This is where topical hemostatic agents come in.

Role of Topical Hemostatic Agents

Topical hemostatic agents, promising in the battle against postoperative complications, are designed to staunch bleeding and seal the liver resection surface, offering hope for patients and surgeons alike. When standard surgical techniques are not enough to control bleeding, topical hemostatic agents play a critical role by inducing blood clotting, providing an immediate and effective means to stop bleeding. Topical hemostats, including oxidized regenerated cellulose (ORC), gelatin, collagen, thrombin, fibrin sealants, and adhesives, are widely used in hepatic surgery to control bleeding and improve surgical outcomes [3].

Spotlight on Oxidized Regenerated Cellulose Gauze (ORCG)

Oxidized regenerated cellulose gauze (ORCG) is a plant-derived passive hemostat developed over 60 years ago. Initially used as oxidized cellulose (OC) in 1942, ORC was developed by 1960 [4]. ORCG is widely used in medical applications due to its convenience, biocompatibility, and bactericidal properties. When ORCG comes into contact with blood, it forms a brownish or black gelatinous mass that promotes hemostasis by providing a structure for platelet adhesion and aggregation as shown in Fig.1.

Fig.1: Application of Oxidized Regenerated Cellulose Gauze (ORCG) on a porcine liver bleeding model [5]

Commercially Available ORC Products in Gauze Form

ORCG is currently available in many commercial products such as Surgicel Original, Emosist, GELITA-CEL® STANDARD, CuraCel® Standard, Surgi-ORC® Original/Standard and Surgi-ORC® Knit (Aegis Lifesciences Pvt. Ltd.).

Clinical Overview

In 2020, Zhang et al. conducted a prospective randomized controlled clinical trial involving 78 patients undergoing hepatectomy. The study aimed to compare the effectiveness of oxidized regenerated cellulose gauze (ORCG) and oxidized non-regenerated cellulose gauze (ONRCG). Both groups achieved 100% hemostasis within 10 minutes, although the study did not provide details on the materials’ characteristics such as oxidation degree and porosity, which significantly influence hemostatic performance [6].

Oxidized cellulose (OC) vs Oxidized regenerated cellulose (ORC) – Present Takeaway

Oxidized cellulose is highly efficient for hemostasis, degradable, and effectively prevents bacterial growth. Nevertheless, one major drawback is its cytotoxicity due to the strongly acidic nature during degradation. This can lead to foreign body reactions, increased inflammation, and delayed healing [7, 8]. Despite its long-standing use as a hemostatic agent, oxidized cellulose does not fully meet the clinical practice’s diverse demands. Thus, clinicians often prefer oxidized regenerated cellulose (ORC) over oxidized cellulose (OC) due to better cytotoxicity, bactericidal, and hemostatic profiles.

Frequently Asked Questions about ORCG in Liver Surgeries

Q: How does oxidized regenerated cellulose gauze (ORCG) interact with blood to control bleeding? A: When ORCG contacts blood, it forms a gelatinous mass that promotes hemostasis by providing a scaffold for platelet adhesion and aggregation, effectively aiding in blood clotting.

Q: In which specific scenarios during liver surgery is ORCG most effectively used? A: ORCG is particularly effective in controlling diffuse low-pressure bleeding from the liver parenchyma during hepatectomies and other liver resections. It is also used to manage bleeding from small vessels and capillary beds that are difficult to suture or ligate.

Q: How does ORCG enhance the overall outcome of liver surgeries? A: ORCG enhances surgical outcomes by providing rapid and effective hemostasis, reducing intraoperative blood loss, minimizing the need for blood transfusions, and lowering the risk of postoperative complications such as infections.

Q: What factors should surgeons consider when selecting ORCG for bleeding management in liver surgeries? A: Surgeons should consider: – Type and Severity of Bleeding: ORCG specially knit variant is suitable for moderate to severe bleeding but might need to be combined with other techniques for extensive hemorrhage. – Surgical Site Accessibility: The ability to apply ORCG effectively in the specific surgical site. – Patient History: Any previous adverse reactions to hemostatic agents or underlying health conditions that might influence the choice of hemostatic strategy.

Q: How does the application technique of ORCG influence its effectiveness? A: The effectiveness of ORCG depends on proper application. It should be applied directly to the bleeding site with sufficient pressure to ensure good contact. Excess material should be avoided to prevent excessive foreign body reactions.

Innovations and Future Trends

The field of hemostatic agents, including oxidized regenerated cellulose gauze (ORCG), is evolving with several promising advancements:

1. Enhanced Biocompatibility: Research is focusing on optimizing the chemical structure of ORCG to further reduce tissue irritation and enhance the healing process [9]. 2. Improved Bactericidal Properties: Future developments aim to incorporate antimicrobial compounds to boost ORCG’s bactericidal properties, thereby reducing the risk of postoperative infections [10]. 3. Nanotechnology Integration: Utilizing nanotechnology could significantly improve the performance of ORCG by enhancing its surface area and reactivity, leading to faster and more effective hemostasis [11]. 4. Customizable Degradation Rates: Researchers are developing ORCG with tailored degradation rates to match specific tissue healing needs, optimizing both hemostatic effects and tissue integration [12].

Emerging Technologies

Slezak et al. (2021) conducted a comparative efficacy evaluation of recombinant topical thrombin (RECOTHROM®) with a gelatin sponge carrier versus topical oxidized regenerated cellulose (TABOTAMP® / SURGICEL®) in a porcine liver bleeding model. The study highlighted the potential of new hemostatic agents to improve bleeding control in surgical settings [5].

Future Improvements

Rodić-Grabovac et al. (2020) discussed the future applications and developments in oxidized cellulose, emphasizing the potential for new formulations and delivery methods to enhance hemostatic performance and reduce complications [4].

Conclusion

While surgical techniques for managing bleeding during hepatic resections have significantly advanced, the integration of topical hemostatic agents like oxidized regenerated cellulose gauze offers a crucial adjunct to achieve optimal outcomes. These agents enhance the hemostatic process and contribute to improved overall patient care, addressing some of the inherent challenges in liver surgery.

References 1. Bodur MS, Tomas K, Topaloğlu S, Oğuz Ş, Küçükaslan H, Dohman D, Karabulut E, Calik A. Effects of intraoperative blood loss during liver resection on patients’ outcome: a singlecenter experience. Turkish Journal of Medical Sciences. 2021;51(3):1388-95.

2. Alkozai EM, Lisman T, Porte RJ. Bleeding in liver surgery: prevention and treatment. Clinics in liver disease. 2009 Feb 1;13(1):145-54.

3. Genyk Y, Kato T, Pomposelli JJ, Wright Jr KJ, Sher LS, Tetens V, Chapman WC. Fibrin sealant patch (TachoSil) vs oxidized regenerated cellulose patch (Surgicel Original) for the secondary treatment of local bleeding in patients undergoing hepatic resection: a randomized controlled trial. Journal of the American College of Surgeons. 2016 Mar 1;222(3):261-8.

4. Rodić-Grabovac B, SailovićP, Lipić N. Medical and pharmaceutical application of oxidized cellulose. Journal of Chemists, Technologists and Environmentalists. 2020;1(1):1-11.

5. Slezak P, Keibl C, Labahn D, Schmidbauer A, Genyk Y, Gulle H. A comparative efficacy evaluation of recombinant topical thrombin (RECOTHROM®) with a gelatin sponge carrier versus topical oxidized regenerated cellulose (TABOTAMP® / SURGICEL®) in a porcine liver bleeding model. Journal of Investigative Surgery. 2021 Jul 22;34(8):862-8.

6. Zhang C, Fu D, Wang F, Zhong X, Yang L, Wu G, Li B, Zhang J. A randomized controlled trial to compare the efficacy of regenerated and non-regenerated oxidized cellulose gauze for the secondary treatment of local bleeding in patients undergoing hepatic resection. Annals of surgical treatment and research. 2021 Apr;100(4):193.

7. Sezer UA, Sahin İ, Aru B, Olmez H, Demirel GY, Sezer S. Cytotoxicity, bactericidal and hemostatic evaluation of oxidized cellulose microparticles: Structure and oxidation degree approach. Carbohydrate polymers. 2019 Sep 1;219:87-94.

8. Wagenhäuser MU, Mulorz J, Ibing W, Simon F, Spin JM, Schelzig H, Oberhuber A. Oxidized (non)-regenerated cellulose affects fundamental cellular processes of wound healing. Scientific Reports. 2016 Aug 25;6(1):32238.

9. Cheng F, Wu Y, Li H, Yan T, Wei X, Wu G, He J, Huang Y. Biodegradable N, O-carboxymethyl chitosan/oxidized regenerated cellulose composite gauze as a barrier for preventing postoperative adhesion. Carbohydrate polymers. 2019 Mar 1;207:180-90.

10. Cheng F, He J, Yan T, Liu C, Wei X, Li J, Huang Y. Antibacterial and hemostatic composite gauze of N, O-carboxymethyl chitosan/oxidized regenerated cellulose. RSC advances. 2016;6(97):94429-36.

11. Cheng F, Liu C, Li H, Wei X, Yan T, Wang Y, Song Y, He J, Huang Y. Carbon nanotube-modified oxidized regenerated cellulose gauzes for hemostatic applications. Carbohydrate polymers. 2018 Mar 1;183:246-53.

12. Bazghaleh AA, Dogolsar MA. Preparation of degradable oxidized regenerated cellulose gauze by zinc modification on HNO 3/Cu oxidized viscose fibers. fibers and polymers. 2019 Jun;20:1125-35.