#Superdisintegrants

[mohammeddd155]

Starch is a generic term for carbohydrate particles found in many plants. Starch grains swell in contact with water, and this appears to be an important property that relates to their use as tablet disintegrants. Sodium starch glycolate is the sodium salt of cross-linked carboxymethylated starch (chemically modified starches). When viewed under the microscope it has the characteristic appearance of starch grains, but with small particles of sodium glycolate and sodium chloride adhering to the surface of the starch grains.

There are many different sources and several different grades of sodium starch glycolate available using different sources of starch, and different types and levels of cross-linking. These differences have a significant influence on the choice of the appropriate grade for a particular application and process.

Pharmaceutical Use as a Superdisintegrants

Superdisintegrants represent a new generation of disintegrants, significantly more effective and requiring lower concentrations compared to traditional disintegrants. The first superdisintegrant to be introduced was sodium starch glycolate. The development was probably inspired by a need to have a disintegrant that was effective at lower concentrations and could be used more easily in direct compression formulations.

The article: https://pharmatech-rx.com/sodium-starch-glycolate/

The website: https://pharmatech-rx.com/

[helthcareheven]

Swift Solutions: Orodispersible Tablets for Quick Relief

What is it? Orodispersible tablets, also known as mouth-dissolving tablets, are tablets that disintegrate rapidly in the oral cavity within seconds, usually without the need for water or chewing. They are designed in such a way that they disintegrate or dissolve in the mouth within a few seconds when placed on the tongue. This allows patients who have difficulty in swallowing regular tablets or capsule dosage forms to easily take their medication.

Tablet manufacturing process The manufacturing process of mouth-dissolving tablets differs from traditional compressed tablet manufacturing process. The ingredients used include superdisintegrants like crospovidone or sodium starch glycolate in higher quantities compared to regular Orodispersible tablets. The active pharmaceutical ingredient along with these superdisintegrants and other excipients are mixed uniformly. The blended mixture is then compressed into tablets using special compression forces and punched into tablet shapes. Subsequent coating can be done to disguise any unpleasant taste if required. Proper blending is critical to obtain uniform and rapid dispersibility of the tablet.

Advantages over regular tablets Mouth-dissolving tablets offer several advantages over conventional tablets for various patient groups: - Easy to administer: They dissolve rapidly in the oral cavity, eliminating the need to swallow tablets with water for patients who have dysphagia or difficulty in swallowing. This makes medication compliance very easy for elderly patients and children. - Rapid onset of action: Since they dissolve/disintegrate in the oral cavity quickly, the active ingredients are absorbed through buccal mucosa and sublingual blood vessels leading to a faster onset of therapeutic action compared to ingestion. - Alternative for swallowing difficulties: Patients with dysphagia due to conditions like stroke, Parkinson's disease can easily take mouth-dissolving tablets rather than regular dosage forms. - Acceptability for pediatric patients: Orodispersible tablets are preferred over syrups for children as they are easier to administer and carry. It also helps in maintaining accurate dosing. - Improved solubility: For drugs that have poor solubility, disintegration of the tablet permits the active ingredient to dissolve rapidly leading to increased bioavailability. - Pleasant taste: Drugs with unpleasant or bitter taste can be formulated into mouth-dissolving tablets and the coating masks the bad taste. Sugar based coatings provide a pleasant sweet taste.

Applications in different therapeutic areas Due to these advantages, mouth-dissolving tablets have huge potential for medications in different disease conditions where rapid onset or ease of administration plays a crucial role:

Acute conditions: - Pain relief tablets like analgesics, paracetamol dissolve fast providing immediate relief from headaches, etc. - Cough and cold preparations dissolve rapidly to provide timely relief from symptoms.

Pediatrics: - Antibiotics, antipyretics in pediatric formulations are preferred in mouth-dissolving tablets form instead of syrups for easy dosing. - Iron supplements, folic acid supplements are available in mouth dissolving forms for children.

Geriatrics: - Anti-hypertensive drugs with a rapid onset of action like nitroglycerin are preferred in this format. - Anti-Parkinson's drugs for immediate relief from symptoms on awakening. - Supplements containing vitamins, minerals, calcium can be easily administered to bed-ridden or dependent elderly patients.

Mental illnesses: - Anti-anxiety drugs that work fast through sublingual absorption help in panic attacks. - Anti-depressants that show early improvement in mood and symptoms.

Drawbacks and challenges While orodispersible tablets are extremely beneficial for certain patient groups, they also have some drawbacks:

- Expensive to manufacture: The specialized manufacturing process and additional cost of super disintegrants make them more expensive than regular compressed tablets. - Stability issues: They have more stability issues compared to compressed tablets due to higher porosity and rapid disintegration properties. Special environmental conditions are required during storage. - Lack of sharpness: Due to soft texture, shape after compression tends to be less defined or rounded edges compared to regular tablets. - Bitter drugs: Masking bitter taste of active ingredients continues to be a challenge.

Conclusion Despite some limitations, orodispersible tablets represent a major breakthrough in dosage form design, offering ease of dosing and administration to a variety of patient populations. Further research in enhancing stability and taste masking can help maximize the benefits of this innovative dosage form, potentially expanding its applications in the treatment of myriad acute and chronic health conditions. When formulated properly using suitable excipients, mouth-dissolving tablets present a patient-centric solution for improving medication adherence.

[rohit0024]

Superdisintegrants Market Worth $487.0 Million By 2025 | CAGR 7.2%

Superdisintegrants Market Growth & Trends The global superdisintegrants market is expected to reach USD 487.0 million by 2025, according to a new report by Grand View Research, Inc. Superdisintegrants help in the disintegration of tablet or capsule content into small particles and create a greater surface area for speedy drug release. A number of fast disintegrating tablets such as salbutamol…

[jagabrialwatlean111]

Superdisintegrants market is experiencing a surge in sales across the globe, and it has been considerably boosted by technological advancement.

[ijtsrd]

Formulation and Evaluation of Amlodipine Fast Dissolving Tablets

by Aparna. P | Dr. Subash Chandran M. P | Remya S B "Formulation and Evaluation of Amlodipine Fast Dissolving Tablets" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019, 

URL: https://www.ijtsrd.com/papers/ijtsrd29563.pdf  

Paper URL: https://www.ijtsrd.com/pharmacy/pharmaceutics/29563/formulation-and-evaluation-of-amlodipine-fast-dissolving-tablets/aparna-p

review papers, call for paper social science, submit paper online 

Fast dissolving tablet is a new era for successful development of controlled release formulation along with various features to provide successful drug delivery. In the present study, an attempt was made to design and evaluate fast dissolving tablets of Amlodipine besylate, which is used commonly for the treatment of angina pectoris. The tablets were prepared by direct compression method followed by sublimation method using super disintegrants sodium starch glycolate, crosspovidone and croscarmellose sodium. The prepared powder blends were evaluated for preformulation parameters. The tablets were evaluated for thickness, hardness, weight variation, drug content uniformity, friability and in vitro drug release studies. In vitro drug release studies were performed by using USP type II apparatus paddle method at 50 rpm in 900 ml of 0.1N HCl as dissolution medium for 30 minutes at 37±0.5°C. The formulation F9 containing Croscarmellose sodium 7 showed better disintegration and dissolution up to 30 minutes. Hence, formulation F9 was considered as optimized formulation which showed the best drug release profile up to 30 minutes. The results of mathematical model fitting of data obtained indicated that, the best fit model in all the cases the release was found to be by diffusion and fickian release. The results of FTIR analysis showed that there was no physical and chemical interaction between drug and other excipients. The study indicates that the fast dissolving tablets of Amlodipine besylate can effectively reduce the adverse effects and frequency of administration of the drug. 

[vijayanger12]

The global Superdisintegrants market size is estimated to be worth US$ 253.2 million in 2021 and is forecast to a readjusted size of US$ 367.5 million by 2030 with a CAGR of 5.4% during the forecast period 2022-2030.

[rohit0024]

Superdisintegrants Market Worth $487.0 Million By 2025 | CAGR 7.2%

Superdisintegrants Market Growth & Trends The global superdisintegrants market is expected to reach USD 487.0 million by 2025, according to a new report by Grand View Research, Inc. Superdisintegrants help in the disintegration of tablet or capsule content into small particles and create a greater surface area for speedy drug release. A number of fast disintegrating tablets such as salbutamol…

[jagabrialwatlean111]

Superdisintegrants market is experiencing a surge in sales across the globe, and it has been considerably boosted by technological advancement.

[wither3344]

Global Superdisintegrants Market

[navabharatlive]

Market Research Future (MRFR) speculates that the global superdisintegrants systems market is slated to garner USD 576.2 million, grabbing a CAGR of 7.9% during the forecast period (2018 to 2023). Increased production of generic drugs is predicted to favor the market growth in the coming years. Disintegrants are referred to as substances which are generally included in drug formula in order to allow proper disintegration of the tablet or capsule into dissolvable particles. Superdisintegrants are added to drug formulation to facilitate the dissolution of the capsule content into reduced particles. Crospovidone, sodium starch glycolate, and croscarmellose sodium are some of the widely used products.