#Sorafina

[arecharh]

Sorafenib in the Treatment of Advanced Hepatocellular Carcinoma

All about Sorafenib’s use in Advanced Hepatocellular Carcinoma

Background

Sorafenib is an oral kinase inhibitor that has been approved by the FDA. It is a prescription medicine that is used to treat a variety of cancer-related illnesses. The following are some of its most relevant indications: 

Advanced Hepatocellular Carcinoma

Advanced Renal Cell Carcinoma

Metastatic, Differentiated Thyroid Carcinoma

Hepatocellular Carcinoma

Hepatocellular Carcinoma is a type of primary liver cancer that occurs most often in patients with severe liver disease like Hepatitis B or C. It is the third most common type of cancer, one of the leading causes of mortality concerning cancer. 

Sorafenib is the standard treatment option that is currently available for patients diagnosed with Advanced Hepatocellular Carcinoma. More significantly, it is the first-line treatment method for those patients of HCC that are not eligible for resection therapy.

Dose 

Sorafina Sorafenib for Hepatocellular Carcinoma Tablet should be taken twice a day at a dose of 400 mg (2 × 200 mg tablets). The dose should be administered without food for better efficacy (provided: at least 1 hour before or 2 hours after food). Therapy with this medicine should be undertaken till the patient no longer benefits from it or when there is clear evidence of intolerable toxicity.

Role and Mechanism 

Sorafenib, being a kinase inhibitor, interacts with certain types of kinases including intracellular and cell surface kinases. These include CRAF, KIT, FLT-3, VEGFR-2, BRAF, VEGFR-3, mutant BRAF, and PDGFR-ß. By such inhibitions, cell proliferation also gets inhibited. 

Efficacy 

The efficacy of Sorafenib (SORAFINA) can be described on the basis of hematological factors like hemoglobin, platelets, white blood cell levels, plus liver function factors like serum bilirubin, aspartate transaminase (AST), serum albumin levels, alkaline phosphatase (ALP), and alanine transaminase (ALT). Based on such factors, the results of certain trials demonstrated better outcomes in patients. This showed that Sorafenib can act as a promising clinical solution for Advanced Hepatocellular Carcinoma.

Limitations

Patients with Advanced Hepatocellular Carcinoma who are administering Sorafenib should be monitored for the following adverse reactions. The below-mentioned points are some of the common side effects, along with the actions to be taken by the physician to manage them.

Grade 2 or above Cardiac ischemia:     Discontinue the use of Sorafenib tablets permanently in such a case. Do     not resume. 

Congestive Heart Failure:     In the case of Grade 3 congestive heart failure, interrupt the therapy     until the disease reaches below Grade 1. Once reached, administer a     one-level decreased dose. Whereas in the case of Grade 4 congestive heart     failure, discontinue permanently and do not resume. 

Hemorrhage requiring medical intervention:     In the case of Grade 2 Hemorrhage, discontinue the treatment permanently     and do not resume. Whereas in the case of Grade 2 asymptomatic, treat     using anti-hypertensive therapy. Continue the use of Sorafenib as per the     schedule and closely monitor the patient’s blood pressure.

Hypertension: In the case of Grade 2     (symptomatic/persistent), interrupt the treatment until the symptoms     resolve. 

Gastrointestinal Perforation:     Any Grade Gastrointestinal Perforation requires permanent discontinuation     of this medication. 

[radhika677]

Sorafenib tablets price

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[oncologyadvice]

sorafenib price

Sorafina is an anti-cancer medicine available as tablets. It is indicated for the treatment of various cancers. These include kidney cancer and liver cancer. It is also expected to manage tumors of the thyroid gland that are radioactive iodine resistant. Sorafina contains sorafenib (200mg/tablet), a targeted therapy medicine. It may show side effects like stomach bloating & pain, fever, chills, heavy menstrual flow, etc. To know about the sorafenib price and its availability in your country, visit Magicine Pharma. Get up to 30% off on all specialty medicines.

[arecharh]

Sorafenib for Metastatic Thyroid Cancer

All about Sorafenib’s use in Differentiated Thyroid Carcinoma

Abstract 

Sorafenib is an approved drug belonging to the class of kinase inhibitors. It is a prescription medication that is used in the treatment of several conditions associated with cancer. Its major indications include the following: 

Treatment of patients diagnosed with Unresectable     Hepatocellular Carcinoma (HCC) i.e. those patients of HCC that are not     eligible for resection therapy. 

Treatment of patients diagnosed with Advanced Renal     Cell Carcinoma. 

Treatment of patients diagnosed with locally recurrent     or metastatic, progressive, Differentiated Thyroid Carcinoma (DTC),     provided: refractory to radioactive iodine treatment. 

Sorafenib for Differentiated Thyroid Carcinoma is a major boon to the patients. The drug significantly improves progression-free survival when used in subjects with Metastatic Thyroid Cancer. It may also benefit patients who are no longer responding to therapy with radioactive iodine.

Role and Mechanism

Metastatic Thyroid Cancer is one of the most researched diseases in the field of Oncology. However, the use of Sorafenib in patients suffering from such a condition is no less a positive sign. Being a multikinase inhibitor, Sorafenib (SORAFINA) interacts with and inhibits certain intracellular and cell surface kinases namely CRAF, BRAF, mutant BRAF, KIT, FLT-3, VEGFR-2, VEGFR-3, and PDGFR-ß. Since most of these kinases play a vital role in the process of angiogenesis, such inhibitions reduce blood flow to the tumor. Due to this, the genetic transcription that involves tumor angiogenesis and cell proliferation are also inhibited. Thus, cell death occurs. 

Dose 

The recommended dose of Sorafenib is 400 mg (2 x 200 mg tablets) administered twice daily. The dose should be ideally taken without food (at least 1 hour before or 2 hours after having a meal). Treatment with this drug should continue until the patient is no longer getting the benefits from therapy or until evidence of unacceptable toxicity is observed. 

Efficacy 

More than seven trials were conducted involving patients with Differentiated Thyroid Carcinoma (papillary, follicular, and poorly differentiated). The results comprising analysis of the response, disease progression, toxicities, and intolerance demonstrated a promising role of Sorafenib in patients with DTC. However, careful management of adverse reactions is also needed. 

Limitations 

Temporary interruptions of Sorafenib are prescribed in patients with Thyroid Cancer that undergo major surgical operations or experience adverse reactions during the treatment period. 

Although Sorafenib improves the overall survival of patients, it is important to look out for the right patients (as per the eligibility) and precise management of possible side effects. Plus, the trials depict that the survival of patients is dependent on liver function. Therefore, this should be made clear to the patients prior to the therapy.

[radhika677]

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[radhika677]

Buy online Sorafina (Sorafenib) 200mg tablet at an honest price on Magicine Pharma. Get 20% off on Sorafina tablet price in India.This medication is prescribed in the treatment of Kidney cancer, Liver cancer, and Thyroid cancer. It is an anticancer formulation, which helps in blocking the growth of cancer cells.

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[radhika677]

Lynparza Tablet price in India

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[radhika677]

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Sorafina is an effective prescription regimen for the treatment of certain types of cancers including cancer of the liver, kidney, and thyroid. It comprises a strong anticancer agent namely Sorafenib.get 20% of on  imfinzi prize in india.This drug is available in the form of tablets for oral administration in the fixed strength of 200mg by Arechar Healthycare. Place your online order now to avail sorafenib tablets price and other medicines for all types of Cancers, HIV, and Hepatitis. Enquire about the latest price and pay via secure methods to get fast delivery at your doorstep. Order now!