#SiSaf

[scienza-magia]

Dall'Univaq una cura per l'osteoporosi autosomica

Brevettato all'Aquila farmaco contro malattia rara delle ossa. Dall'Università è stato dato in licenza a un'azienda britannica e ora è in attesa del via libera per la sperimentazione clinica negli Stati Uniti. È nato in Italia, dove è stato brevettato all'Università dell'Aquila, e ora il primo farmaco contro la malattia rara che rende le ossa compatte come marmo e nello stesso tempo fragilissime è in attesa del via libera per la sperimentazione clinica negli Stati Uniti. «Il progetto è cominciato oltre 15 anni fa, grazie ai finanziamenti di Telethon, della Commissione europea e del ministero dell'Università e della Ricerca, ma solo in un secondo momento ci siamo concentrati su come sfruttare le conoscenze di base che fino ad allora avevamo raccolto sull'osteoporosi autosomica dominante per trovare una cura contro questa malattia rara», ha detto all'agenzia giornalistica Ansa la coordinatrice della ricerca, Anna Maria Teti, del dipartimento di Scienze cliniche applicate e biotecnologiche dell'Università dell'Aquila.

Il brevetto riguarda «piccoli Rna, detti siRNA, che regolano la formazione delle proteine da parte di Rna messaggeri: la loro funzione è riconoscere parti di Rna messaggero inducendone la degradazione, in modo che le proteine non si formino», spiega la ricercatrice. «Nel nostro organismo - aggiunge - un sistema fisiologico garantisce l'eliminazione del tessuto osseo vecchio e danneggiato e lo sostituisce con tessuto osso nuovo, rinnovando lo scheletro fino a dieci volte nel corso della vita». Nel caso della malattia delle ossa di marmo, invece, questo meccanismo non funziona regolarmente perché le cellule che eliminano l'osso vecchio non sono attive. Di conseguenza le ossa perdono la struttura cava all'interno, fondamentale per il regolare sviluppo sia del midollo osseo, ricco delle staminali che garantiscono la rigenerazione di sangue e ossa, sia delle connessioni nervose che l'attraversano. Si manifestano così seri problemi che riguardano la comparsa di fratture ricorrenti e di disturbi ematologici e neurologici. Quando l'osteopetrosi si manifesta in forma grave è spesso curabile con il trapianto di midollo osseo. Ci sono invece forme meno gravi, ma non curabili, nelle quali solo una copia del gene malato è mutata e domina su quella normale, inducendo la malattia. «Abbiamo pensato che progettando un siRna che degradi l'Rna messaggero mutato e lasci intatto quello normale, il paziente avrebbe prevalentemente proteine normali», dice Teti. Sono state così sperimentati molti siRNA fino a trovarne uno che «ha funzionato bene sia nelle cellule sia negli animali». Si tratta però di molecole che si degradano rapidamente e che per essere veicolate nell'organismo devono essere protette. I ricercatori italiani si sono perciò rivolti a un'azienda britannica, la SiSaf, specializzata nella produzione di nanoparticelle. «Ne abbiamo selezionata una che funziona bene sul modello animale della malattia, il brevetto è stato dato loro in licenza e - dice Teti - abbiamo cominciato a considerare la possibilità dello studio clinico». La domanda sarà presentata all'ente americano per la sorveglianza sui farmaci, la Food and Drug Administration, perché negli Stati Uniti c'è un grande gruppo di pazienti affetti da questa forma di osteopetrosi. «Il percorso per la sperimentazione clinica è ancora lungo, ma - conclude la ricercatrice - la cosa interessante che è questa tecnologia si può applicare ad altre malattie con caratteristiche genetiche simili». Read the full article

[roll-a-troll]

Name: Mr. Sisafe Noxosa Ancestor: The Politics Strife Specibus: bowkind Blood Color and Sign: Jade; Virist Handle: therapeuticGiant Lusus: monkeydad Pronouns: he/him Age: 13 sweeps Interests: breadmaking and stuffed toy collecting Sexuality: Fond of Men Class: Sylph Land: Land of Temperance and Bounce, a creepy place, with worrisome Matamata Turtle consorts. It is a place full of savanas and pleasant forests. Hephaestus is the land. Quirk: don't use emotes via roll-a-troll https://ift.tt/PFE8vfb, do as you please

[maksiov]

3d mural "Origins" in Sibiu city, by Ukrainian artist Alex Maksiov as a part of SISAF Sibiu Street Art Festival) 2020, Romania

[kitrakitra]

[cristineagoe]

#recis #penumbra #fence #prison #bars #figurative #graffiti #streetart #photorealism #abstraction #double #sadness #confinement #school #education #kid #girl #boy #hermaphrodite #sisaf #sweetdamagecrew #sibiu #romania (at Colegiul Economic "George Baritiu", Sibiu)

[myabhijitr]

Nano-Silicon Drug Delivery Platform Market – Detailed Analysis of Current and Future Industry Forecast to 2028

The market for Nano-Silicon Drug Delivery Platforms is categorized according to the product type. This market research report focuses on the global and regional markets. This research report offers insights on key growth and influencing factors for the Nano-Silicon Drug-Delivery Platforms. It also evaluates different methods and industry pioneers in the Nano-Silicon Drug Delivery Platform Market. The report also provides a detailed analysis of the competition in the market. MSNs can be produced in several ways. The most popular method is active targeting, where a silica-based nanoparticle is surface-grafted on a selective cell surface. This type of drug delivery is referred to as ligand-receptor binding. As such, it can be used for several applications. This is a promising way to deliver low-dose drugs to specific sites. Moreover, the product can be manufactured for a variety of purposes.

Get PDF Sample Copy (Including Full TOC, List of Tables & Figures, Chart) @ https://www.coherentmarketinsights.com/insight/request-sample/45

Other than the biomedical industry, the use of nano-silicon particles in targeted tumor therapies is gaining momentum. Various organizations around the world are studying the potential of using this type of drug delivery in therapeutics. The goal is to develop a nanoparticle-based technology that can deliver medications for weeks or even months at a time. It will revolutionize the pharmaceutical industry, and it will provide affordable targeted drug therapies to patients. In addition to the manufacturing of nano-silicon drugs, the development of new methods of drug delivery using nano-silicon technology is currently being researched by several institutes. For instance, the Icahn School of Medicine at Mount Sinai conducted a clinical trial with gold-silica nanoparticle-based photothermal cancer therapy. Similarly, scientists at the Georgia Institute of Technology reported the development of 200-nanometer silica spheres for drug delivery in certain parts of the body.

Potential Applications

SiSafe will be of significant use to pharmaceutical, animal health, biotech and cosmeceutical companies to formulate and package drugs that are difficult to formulate otherwise. Companies finding better solutions for their existing drugs can incorporate this technology to improve their product quality. Also, new drugs used for chronic diseases can be delivered at a low dose to the target sites with the nano-silicon drug delivery platform.

This new nanotechnology-based drug delivery platform offers competitive advantages such as improved safety, efficacy, controlled release and desired time of onset of drug release. After years of research and development, and extensive capital investment, SiSafe nano-silicon drug delivery platform is ready for commercialization. SiSaf is looking to partner with drug developers who desire to improve their formulation with controlled releases and lower doses. SiSaf received a funding of USD 4.9 million from Singapore’s Vickers Venture Partners and Exen Capital recently in November 2016. This partnership is anticipated to be of great aid for SiSaf to reach more markets globally.

Nano-silicon Drug Delivery Platforms are being used by pharma companies to deliver drugs to patients. SiSafe is used in the manufacture of nanoporous silicon-based microporous materials. Its unique properties enable it to load bioactive cargo through passive adsorption or active anchoring. Moreover, the mesoporous silicon-based nanocarriers have caps that are stimuli responsive, which allows the release of the cargo with control.

Request PDF Brochure with Latest Insights @ https://www.coherentmarketinsights.com/insight/request-pdf/45

Aside from the potential for targeted tumor therapy, nano-silicon particles can also be used for other purposes such as cancer detection. They are currently being studied by different institutions and are expected to revolutionize the pharmaceutical industry. It will be able to deliver drugs for weeks or even months, which is a significant benefit. This technology is a breakthrough in drug delivery and will lead to lower costs for treatments. It is important to note that the nano-silicon particles can also be modified to be highly biodegradable.

Key Developments

Several institutes are focused on R&D related to nano-silicon drug delivery approaches. For instance, in August 2019, researchers from Icahn School of Medicine at Mount Sinai conducted a clinical trial for gold-silica nanoparticles-based photothermal cancer therapy.

Similarly, in June 2019, researchers from Georgia Institute of Technology reported development of silica spheres of around 200 nanometers in size that can be used for drug delivery to eliminate malignant cells only in certain parts of the body, in the journal Angewandte Chemie International Edition.

In March 2018, researchers from the University of South Australia reported the use of an electrospun composite of poly (ε-caprolactone) fibers and porous silicon nanoparticles as an effective system for the tunable delivery of camptothecin, a topoisomerase inhibitor linked to a cyclodextrin-based polymer to form the investigational anti-cancer drug CRLX101.

[rudyroth79]

Știri: Festivalul de Artă Stradală de la Sibiu (SISAF, 10–16 august 2020) Ediția a VI-a a Festivalului de Artă Stradală de la Sibiu (SISAF) va avea loc între 10–16 august 2020.

[martynnx-blog]

Nano-silicon Drug Delivery Platform Market Forthcoming Developments, Business Opportunities & Future Investments

Safe and effective drug delivery is a major challenge against the pharmaceutical and biotechnology companies. Companies formulate their drugs in various dosage forms such as capsules, powders, inhalers, liquid, drops, tablets, transdermal patches, depot injection, and gels to address the drug delivery challenges in different conditions. Moreover, advancement in research has enabled controlled and sustained release of drugs to decrease the dosage and provide long term effect of the drug. Furthermore, new technologies such as nanotechnology and antibody-drug conjugate are being introduced to minimize cost and increase bioavailability. In all, there is all-together a new wave of innovation in life science sector that delivers medicines at the targeted site in right dose.

Download PDF Brochure Of This Research Report @ https://www.coherentmarketinsights.com/insight/request-pdf/45

Potential Applications

SiSafe will be of significant use to pharmaceutical, animal health, biotech and cosmeceutical companies to formulate and package drugs that are difficult to formulate otherwise. Companies finding better solutions for their existing drugs can incorporate this technology to improve their product quality. Also, new drugs used for chronic diseases can be delivered at a low dose to the target sites with the nano-silicon drug delivery platform.

Nano-silicon Drug Delivery Platform to enable Low Cost Drug Delivery

Research for the use of nano-silicon particles in targeted tumor therapy is under progress. The study being conducted by various organizations globally including Tel Aviv University, Technion – Israel Institute of Technology in collaboration with Massachusetts Institute of Technology (MIT) and the Harvard Medical School are of the opinion that nano-silicon particles could deliver drugs over a long period of time, may be for weeks or even months. Such advancement in drug delivery technologies will revolutionize the pharmaceutical and biopharmaceutical drug industry by offering targeted drug therapies at a low cost.

[affiliatetejas]

Nano-Silicon Drug Delivery Platform Market 2026

To Gain More Insights into the Nano-Silicon Drug Delivery Platform Market, Browse Summary of the Research Report –

Safe and effective drug delivery is a major challenge against the pharmaceutical and biotechnology companies. Companies formulate their drugs in various dosage forms such as capsules, powders, inhalers, liquid, drops, tablets, transdermal patches, depot injection, and gels to address the drug delivery challenges in different conditions. Moreover, advancement in research has enabled controlled and sustained release of drugs to decrease the dosage and provide long term effect of the drug. Furthermore, new technologies such as nanotechnology and antibody-drug conjugate are being introduced to minimize cost and increase bioavailability. In all, there is all-together a new wave of innovation in life science sector that delivers medicines at the targeted site in right dose.

https://www.coherentmarketinsights.com/ongoing-insight/nano-silicon-drug-delivery-platform-market-45

Nanotechnology-based platforms are gaining significant importance in research and product development due to the enormous benefits they offer in terms of drug stability, bioavailability, dosage, and shelf-life.  Various types of nano-carriers or nanoparticles such as liposomes, magnetic particle, dendrimers, silver nanoparticle, silica nanoparticle, and polymeric micelles, carbon nanoparticles and drug-conjugate nanoparticles are used in different industries to cater the exact need or product.                                                                    

SiSaf’s new drug delivery technology called SiSafe is a patented elemental nano-silicon porous structure with a massive surface area. A higher surface area provides high drug-loading capacity and thus significant increase in bioavailability of even the most hydrophobic compounds. So, a less soluble drug that needs to be injected directly in the bloodstream can have enhanced solubility through SiSafe nano-silicon platform. Molecules are incorporated within the nanopores, thus stabilizing the instable molecules and increasing the bioavailability of the drug. SiSafe is a biodegradable technology which enables customizing the rate of onset and release by altering the physical factors of the carriers such as linkage method, porosity, particle size, and pore width.

“We Do Offer Sample of Nano-Silicon Drug Delivery Platform Market Report. Kindly go through the follow information in order to access sample copy.”

https://www.coherentmarketinsights.com/insight/request-sample/45

Table of Contents

https://www.coherentmarketinsights.com/ongoing-insight/toc/45

Top players in the market

Several institutes are focused on R&D related to nano-silicon drug delivery approaches. For instance, in August 2019, researchers from Icahn School of Medicine at Mount Sinai conducted a clinical trial for gold-silica nanoparticles-based photothermal cancer therapy.

Similarly, in June 2019, researchers from Georgia Institute of Technology reported development of silica spheres of around 200 nanometers in size that can be used for drug delivery to eliminate malignant cells only in certain parts of the body, in the journal Angewandte Chemie International Edition.

Research methodology adopted by Coherent Market Insights

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

Primary Research (Trade Surveys and Experts Interviews)

Desk Research

Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.

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About Us:

Coherent Market Insights is a global market intelligence and consulting organization focused on assisting our plethora of clients achieve transformational growth by helping them make critical business decisions.

Contact Us:

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Email: sales@coherentmarketinsights.com

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Visit our Blog: https://hospitalhealthcareblog.wordpress.com/

[maksiov]

My recent #mural “Origins” for #SISAF art festival 2020 with the theme #origins in #Sibiu city #Romania Str.Nicolae Lorga 70 #3dmural #muralism #streetart #urbanart #muralist #alexmaksiov #maksiov #opticalillusion #3dstreetart #3dart #3dillusion #streetartist (at Sibiu, Romania) https://www.instagram.com/p/CD00IcoF6Iq/?igshid=sx6com7l52id

[kitrakitra]

[mabackspace]

II Simpósio Internacional de Saúde e Aptidão Física de Agentes da Segurança Pública – II SISAF

A Universidade de Brasília e a Faculdade de Educação Física, por meio do Grupo de Estudos em Fisiologia e Epidemiologia do Exercício e da Atividade Física (GEAFS), em parceria com o Corpo de Bombeiros Militar do Distrito Federal – CBMDF e o Laboratório de Pesquisa sobre Gestão do Esporte – GESPORTE, e o apoio financeiro da Fundação de Apoio à Pesquisa do Distrito Federal (FAPDF), realizará o II Simpósio Internacional de Saúde e Aptidão Física de Agentes da Segurança Pública – II SISAF.

O evento terá como tema central a saúde e aptidão física de agentes da segurança pública e será constituído por mesas redondas e palestras, abrangendo distintos campos de atuação, com foco no risco cardiovascular a que são submetidos os profissionais da segurança pública, e sua associação com a aptidão física. Nesta segunda edição foram incluídos também outros temas críticos para a saúde dos agentes da segurança pública, como a qualidade do sono e a saúde mental.

O IIº SISAF acontecerá entre dias 19 a 22 de março de 2019, na Academia de Bombeiro Militar do Distrito Federal (Auditório Coronel José Nilton Matos), situado no Setor Policial Sul.

Inscrições

https://ift.tt/2HrHpem

Obs.: Visando garantir o acesso a todos interessados, pedidos de isenção do valor da taxa de inscrição poderão ser feitos diretamente à organização do II SISAF por meio do email:

organizacao-sisaf-aroba-gmail-com

O evento contará com 5 palestras internacionais, entre os quais uma das maiores especialistas mundiais no tema, a Prof. Dra. Denise Smith, do Skidmore College – US e a Profa. Dra. Catrine Tudor-Locke, líder mundial na área de avaliação do nível de atividade física; 6 palestrantes nacionais de fora do DF, entre os quais destaca-se do Dr. Victor Matsudo, líder mundial na área de promoção da atividade física para a saúde, e outros 17 palestrantes de reconhecida qualidade científica, oriundos do próprio Distrito Federal.

A proposta de realização deste evento é decorrente da crescente necessidade de reunião de especialistas para discutir temas de extrema importância para a saúde de profissionais que prestam relevantes serviços para a sociedade e que configuram um número muito elevado de trabalhadores. A proposta do evento vem também em decorrência do amadurecimento de relações institucionais e de desenvolvimento técnico-científico no Distrito Federal em área tão sensível e ainda carente de melhor mapeamento e intervenção na realidade do Distrito Federal. Diante do grande sucesso da primeira edição, constatou-se a necessidade de uma nova edição, com a proposta de realização periódica a cada dois anos.

Programa do evento

Postagem equipe GESPORTE

II Simpósio Internacional de Saúde e Aptidão Física de Agentes da Segurança Pública – II SISAF publicado primeiro em: http://gesporte.blogspot.com

Este conteúdo apareceu primeiro em: https://ift.tt/2M0dYOl

[jurnalbucuresti-blog]

New Post has been published on JurnalulBucurestiului.Ro

New Post has been published on http://bit.ly/2ssOQHA

Sibiu International Street ART Festival 2017, ediția a III-a

Sibiu International Street ART Festival anunță cei 24 de artiști români și 3 internaționali care vor revitaliza orașul prin artă urbană la ediția a III-a, desfășurată în perioada 3-9 iulie 2017.

În acest an, primul Tur de Artă Stradală din România, care conține deja 31 de lucrări realizate în 11 locații din Sibiu, va fi îmbogățit cu alte murale ce vor colora zidurile gri ale școlilor și liceelor din oraș. Dintre zecile de artiști străini bine cotați care și-au dorit să își aducă aportul la ridicarea nivelului estetic al acestor locații, au fost aleși Urka din Italia, Wasp Elder din UK și Camilo din Portugalia, care revine după o altă lucrare realizată anul trecut pe fațada unui liceu.

Alături de ei, nume de referință ale street art-ului din România sau artiști plastici aflați la început de drum vor face parte din line-up-ul acestei ediții. Printre aceștia se regăsesc cunoscuții Sweet Damage Crew, Kitră, The Orion sau Pisica Pătrată – artistul care semnează imaginea ediției 2017, dar și Ștefan Radu Crețu, care va realiza o instalație.

Autorii noilor lucrări incluse în Sibiu Street Art Tour sunt artiști care s-au înscris la selecția proiectelor de artă stradală, desfășurată în luna aprilie, urmând tema ediției „a, b, z / 1, 2, 9 / smile, love, like”. Aceștia vor putea realiza murale pe zidurile instituțiilor de învățământ la singurul festival din lume care reușește să facă asta, an de an, cu sprijinul Primăriei. În completarea lor, alți artiști vor avea șansa să își implementeze pentru prima dată ideile pe panouri, chiar în centrul istoric al orașului, în timp ce iau pulsul trecătorilor și al publicului.

În paralel cu munca depusă de artiștii street art în cele 7 zile de festival, SISAF propune un program plin de activități conexe. Vor fi organizate conferințe și dialoguri despre artă și spațiu urban, întâlniri cu artiștii, workshop-uri, tururi și expoziții de fotografie. Piața Huet – zona 0 a festivalului, devine epicentrul street art-ului, fiind locul de întâlnire al iubitorilor și pasionaților de artă realizată și expusă în stradă. Aici sunt programate concerte cu artiști din diverse zone muzicale, care vor anima atmosfera. Șuie Paparude și Dragonu AKA 47 și-au confirmat deja prezența la festival și vor cânta în cinstea spiritului liber al celor care simt și rezonează cu cultura străzii.

Sibiu International Street ART Festival este un eveniment cofinanțat de Consiliul Local Sibiu și Primăria Municipiului Sibiu și este susținut de proiectul „Culorile României” – Policolor. Mai multe detalii despre festival găsiți pe www.streetartfestival.ro

[globalmarketresearchbog-blog]

Nano-silicon Drug Delivery Platform Market - Global Industry Insights, Trends, Outlook, and Opportunity Analysis, 2016-2024

Nano-silicon Drug Delivery Platform Market overview:

Safe and effective drug delivery is a major challenge against the pharmaceutical and biotechnology companies. Companies formulate their drugs in various dosage forms such as capsules, powders, inhalers, liquid, drops, tablets, transdermal patches, depot injection, and gels to address the drug delivery challenges in different conditions. Moreover, advancement in research has enabled controlled and sustained release of drugs to decrease the dosage and provide long term effect of the drug. Furthermore, new technologies such as nanotechnology and antibody-drug conjugate are being introduced to minimize cost and increase bioavailability. In all, there is all-together a new wave of innovation in life science sector that delivers medicines at the targeted site in right dose.

Nanotechnology-based platforms are gaining significant importance in research and product development due to the enormous benefits they offer in terms of drug stability, bioavailability, dosage, and shelf-life.  Various types of nano-carriers or nanoparticles such as liposomes, magnetic particle, dendrimers, silver nanoparticle, silica nanoparticle, and polymeric micelles, carbon nanoparticles and drug-conjugate nanoparticles are used in different industries to cater the exact need or product.

Get PDF Research Brochure for more Professional and Technical Insights: https://www.coherentmarketinsights.com/insight/request-sample/45

SiSafe Nano-silicon Drug Delivery Platform

SiSaf’s new drug delivery technology called SiSafe is a patented elemental nano-silicon porous structure with a massive surface area. A higher surface area provides high drug-loading capacity and thus significant increase in bioavailability of even the most hydrophobic compounds. So, a less soluble drug that needs to be injected directly in the bloodstream can have enhanced solubility through SiSafe nano-silicon platform. Molecules are incorporated within the nanopores, thus stabilizing the instable molecules and increasing the bioavailability of the drug. SiSafe is a biodegradable technology which enables customizing the rate of onset and release by altering the physical factors of the carriers such as linkage method, porosity, particle size, and pore width.

Potential Applications

SiSafe will be of significant use to pharmaceutical, animal health, biotech and cosmeceutical companies to formulate and package drugs that are difficult to formulate otherwise. Companies finding better solutions for their existing drugs can incorporate this technology to improve their product quality. Also, new drugs used for chronic diseases can be delivered at a low dose to the target sites with the nano-silicon drug delivery platform.

This new nanotechnology-based drug delivery platform offers competitive advantages such as improved safety, efficacy, controlled release and desired time of onset of drug release. After years of research and development, and extensive capital investment, SiSafe nano-silicon drug delivery platform is ready for commercialization. SiSaf is looking to partner with drug developers who desire to improve their formulation with controlled releases and lower doses. SiSaf received a funding of USD 4.9 million from Singapore’s Vickers Venture Partners and Exen Capital recently in November 2016. This partnership is anticipated to be of great aid for SiSaf to reach more markets globally.

Browse Global Strategic Business Report:

https://www.coherentmarketinsights.com/ongoing-insight/nano-silicon-drug-delivery-platform-market-45

Nano-silicon Drug Delivery Platform to enable Low Cost Drug Delivery

Research for the use of nano-silicon particles in targeted tumor therapy is under progress. The study being conducted by various organizations globally including Tel Aviv University, Technion – Israel Institute of Technology in collaboration with Massachusetts Institute of Technology (MIT) and the Harvard Medical School are of the opinion that nano-silicon particles could deliver drugs over a long period of time, may be for weeks or even months. Such advancement in drug delivery technologies will revolutionize the pharmaceutical and biopharmaceutical drug industry by offering targeted drug therapies at a low cost.

About Coherent Market Insights:

Coherent Market Insights is a prominent market research and consulting firm offering action-ready syndicated research reports, custom market analysis, consulting services, and competitive analysis through various recommendations related to emerging market trends, technologies, and potential absolute dollar opportunity.

[vulpeculamayor]

1982 Schwinn Touring Bike $400.

submitted by /u/sisafes [link] [comments]

from bicycling https://ift.tt/3BmXpWv