#Remicade Biosimilar Market Research

[soumyafwr]

Remicade Biosimilar Market Share, Overview, Competitive Analysis and Forecast 2031

[newsmarketreports]

Celltrion Inc.: Financial Performance Overview

Celltrion Financials is a South Korean biopharmaceutical company, known for its leadership in developing biosimilars and biologics. The company focuses on producing affordable, high-quality biologic drugs for the treatment of autoimmune diseases, cancer, and other chronic illnesses. Below is a summary of its financial performance based on available information.

1. Revenue Growth

Strong Sales of Biosimilars: Celltrion has seen consistent growth in revenue, primarily driven by the global sales of its biosimilars such as Remsima (a biosimilar to Remicade), Truxima (a biosimilar to Rituxan), and Herzuma (a biosimilar to Herceptin). These products are approved in multiple regions, including the U.S., Europe, and Asia, contributing significantly to the company's topline.

Year-over-Year Revenue Increase: Celltrion has experienced strong revenue growth in recent years, often reporting double-digit percentage increases in annual sales. This growth is fueled by increasing market adoption of biosimilars and new product launches.

2. Profit Margins

High Gross Margins: Celltrion benefits from relatively high gross margins due to the cost-efficiency of its manufacturing processes and the lower R&D costs associated with biosimilars compared to original biologic drugs. Its state-of-the-art manufacturing facilities in South Korea contribute to economies of scale.

Operating Income: The company’s operating income has also been growing steadily, supported by both rising sales and cost-control measures. Celltrion’s ability to scale production efficiently while maintaining competitive pricing has been a key driver of profitability.

3. R&D Expenditure

Investments in Pipeline Development: Celltrion continues to invest heavily in research and development (R&D), focusing on expanding its biosimilar pipeline and developing new biologic treatments. This includes the development of biosimilars for blockbuster drugs as well as innovative biologics for cancer and autoimmune diseases.

R&D as a Percentage of Revenue: Celltrion’s R&D expenditure represents a significant portion of its annual revenue, reflecting its long-term commitment to innovation and expanding its product portfolio. The company is focused on developing next-generation biologics and biosimilars, which will drive future growth.

4. Global Market Expansion

International Sales Contribution: A significant portion of Celltrion’s revenue comes from its international operations, particularly in Europe and the U.S., where biosimilars have gained widespread acceptance. The company has been actively pursuing regulatory approvals in various regions, which has contributed to its robust revenue growth.

Partnerships and Alliances: Celltrion has established strategic partnerships with global pharmaceutical companies for the marketing and distribution of its biosimilar products. These partnerships have played a key role in driving global sales and market penetration.

5. Impact of COVID-19

COVID-19 Treatment Development: During the COVID-19 pandemic, Celltrion played an active role in developing treatments for the virus. The company developed Regkirona (CT-P59), a monoclonal antibody treatment for COVID-19. This has contributed to additional revenue streams and positioned the company as a key player in pandemic response efforts.

Increased Demand for Biologics: The pandemic heightened the global demand for biologics, which benefited Celltrion’s biosimilar portfolio as healthcare systems sought cost-effective treatments for chronic diseases amidst budget constraints.

6. Outlook and Future Growth

Biosimilar Pipeline: Celltrion’s future growth is expected to be driven by the launch of new biosimilars currently in its pipeline. These include biosimilars for drugs like Humira (adalimumab), which has been one of the world’s top-selling drugs, and other monoclonal antibodies.

Innovative Biologics: Beyond biosimilars, Celltrion is working on developing innovative biologic treatments that could further bolster its revenue streams and market position.

Expansion into New Markets: Celltrion continues to focus on expanding into new international markets, particularly in emerging regions where demand for affordable biologic treatments is increasing.

Conclusion

Celltrion Inc. has demonstrated strong financial performance, supported by its leadership in the biosimilar market, efficient manufacturing capabilities, and strategic international partnerships. With a robust product pipeline, continued R&D investments, and a focus on global market expansion, Celltrion is well-positioned for future growth in the biopharmaceutical industry.

[healthcare-market]

Remicade Biosimilar Market Shares, Strategies and Opportunities 2031

Remicade Biosimilar Market: Overview

A key drive for Remicade biosimilar market stems from the fact that numerous biological innovative products, including monoclonal antibodies (mAbs) are nearing patent expiries. A growing research on developing biosimilars to these is a key trend bolstering the growth prospects. A number of biosimilars to Infliximab (IFX) biological therapy have been approved, notably by the FDA. In the past, IFX was found to be effective in Crohn’s disease (CD) and ulcerative colitis (UC). Particularly, biological therapies including Remicade biosimilar exhibit vast revenue potential for inflammatory bowel disease (IBD). A relentless focus on reducing the overall cost of chronic diseases notably IBD-related healthcare is a key aspect propelling advances in this direction. Great strides have been made in efficacy and safety data, which underpin potential revenue streams in the Remicade biosimilar market. Newer FDA-approved products in the market target patients with ankylosing spondylitis, plaque psoriasis, and psoriatic arthritis.

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Constant focus on expansion of biosimilar portfolios by globally prominent drug makers is a key trend bolstering the prospects in the Remicade biosimilar market. They are increasingly inclined toward offering affordable biological treatment options especially in oncology. However, developing Remicade biosimilar that have low risk factors particularly from risk for serious infection of opportunistic pathogens is veritable challenge that will anchor more research and development funding worldwide.

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Demand for biological products is high for the treatment of a large number of diseases. However, demand for biosimilar products is increasing to lower health care costs. Biosimilar products are derived in reference to biological products and have similar safety, efficacy, purity, and effectiveness when compared to the original products. Biosimilar can be characterized as a sort of biologic item that is profoundly like an as of now FDA approved biologic drug, known as reference drug. Biosimilars are drugs approved by the U.S. FDA and the European Medicine Agency (EMA) and show no clinical and meaningful difference from the reference biological product. These biosimilar products can be approved only for indications which are previously approved for the reference biological product by authorized regulatory bodies.

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In 1998, the U.S. FDA licensed Remicade (infliximab), a monoclonal antibody originally produced by Janssen Biotech, Inc. and Merck & Co. in partnership. Its primary indication included Crohn’s disease in both adult and pediatric patients. It is also indicated for the treatment of ulcerative colitis, spinal psoriatic arthritis, plague psoriasis, and rheumatic arthritis when given in combination with methotrexate. The U.S. FDA approved biosimilar to Remicade named Inflectra on April 05, 2016. Pfizer launched Inflectra in the market at 15% discount on the original market price of the reference product. However, in April 2017, another biosimilar Renflexis (infliximab-abda), a tumor necrosis factor to Remicade by Samsung Bioepis and Merck & Co., was approved to be launched into the market. It is approved for almost all the indications that were approved under Remicade such as ulcerative colitis, spinal psoriatic arthritis, plague psoriasis, rheumatic arthritis, and ankylosing spondylitis.

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Increase in incidence of autoimmune disorders such as rheumatoid arthritis, and psoriasis, patent expiry of branded drugs, and rise in health care costs drive the Remicade biosimilar market. Additionally, faster entry of Biosimilars into the Europe market leads to cost reduction and faster medicines accessibility help to grow this market. However, serious side effects associated with the drug could lead to fatality. This factor restraints the market.

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The global Remicade biosimilar market can be segmented based on approved indication and region. In terms of approved indication, the market can be categorized into ulcerative colitis, rheumatoid arthritis, psoriatic arthritis, plaque psoriasis, Crohn’s disease, and ankylosing spondylitis. Ulcerative colitis and rheumatoid arthritis show higher demand due to increase in number of cases of these diseases. Psoriasis also increase market demand owing to increase in the cases of autoimmune diseases. Based on region, the global Remicade biosimilar market can be segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America dominates the market owing to high incidence of autoimmune diseases and increase in geriatric population. Europe is the second largest market for Remicade. Easy access to biosimilar medications in the region drives the market. India, southeast Asia, and China are emerging markets for biosimilar medicines because of changing lifestyle and increase in healthcare facilities in these regions.

Key players in the global Remicade biosimilar market comprise Alvogen, Napp Pharmaceuticals, Janssen Biotech, Inc., Merck &Co., Pfizer, Inc., Cell Trion, and Nippon Kayaku.

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[gordonwilliamsweb]

Biosimilar Drugs Are Cheaper Than Biologics. Are They Similar Enough to Switch?

It took years for Elle Moxley to get a diagnosis that explained her crippling gastrointestinal pain, digestion problems, fatigue, and hot, red rashes. And after learning in 2016 that she had Crohn’s disease, a chronic inflammation of the digestive tract, she spent more than four years trying medications before getting her disease under control with a biologic drug called Remicade.

So Moxley, 33, was dismayed to receive a notice from her insurer in January that Remicade would no longer be covered as a preferred drug on her plan. Another drug, Inflectra, which the Food and Drug Administration says has no meaningful clinical differences from Remicade, is now preferred. It is a “biosimilar” drug.

“I felt very powerless,” said Moxley, who recently started a job as a public relations coordinator for Kansas City Public Schools in Missouri. “I have this decision being made for me and my doctor that’s not in my best interest, and it might knock me out of remission.”

After Moxley’s first Inflectra infusion in July, she developed a painful rash. It went away after a few days, but she said she continues to feel extremely fatigued and experiences gastrointestinal pain, constipation, diarrhea and nausea.

Many medical professionals look to biosimilar drugs as a way to increase competition and give consumers cheaper options, much as generic drugs do, and they point to the more robust use of these products in Europe to cut costs.

Yet the U.S. has been slower to adopt biosimilar drugs since the first such medicine was approved in 2015. That’s partly because of concerns raised by patients like Moxley and their doctors, but also because brand-name biologics have kept biosimilars from entering the market. The companies behind the brand-name drugs have used legal actions to extend the life of their patents and incentives that make offering the brand biologic more attractive than offering a biosimilar on a formulary, listing which drugs are covered on an insurance plan.

“It distorts the market and makes it so that patients can’t get access,” said Dr. Jinoos Yazdany, a professor of medicine and chief of the rheumatology division at Zuckerberg San Francisco General Hospital.

The FDA has approved 31 biosimilar medications since 2015, but only about 60% have made it to market, according to an analysis by NORC, a research organization at the University of Chicago.

Remicade’s manufacturer, Johnson & Johnson, and Pfizer, which makes the Remicade biosimilar Inflectra, have been embroiled in a long-running lawsuit over Pfizer’s claims that Johnson & Johnson tried to choke off competition through exclusionary contracts with insurers and other anti-competitive actions. In July, the companies settled the case on undisclosed terms.

In a statement, Pfizer said it would continue to sell Inflectra in the U.S. but noted ongoing challenges: “Pfizer has begun to see progress in the overall biosimilars marketplace in the U.S. However, changes in policy at a government level and acceptance of biosimilars among key stakeholders are critical to deliver more meaningful uptake so patients and the healthcare system at-large can benefit from the cost savings these medicines may deliver.”

Johnson & Johnson said it is committed to making Remicade available to patients who choose it, which “compels us to compete responsibly on both price and value.”

Biologic medicines, which are generally grown from living organisms such as animal cells or bacteria, are more complex and expensive to manufacture than drugs made from chemicals. In recent years, biologic drugs have become a mainstay of treatment for autoimmune conditions like Crohn’s disease and rheumatoid arthritis, as well as certain cancers and diabetes, among other conditions.

Other drugmakers can’t exactly reproduce these biologic drugs by following chemical recipes as they do for generic versions of conventional drugs.

Instead, biosimilar versions of biologic drugs are generally made from the same types of materials as the original biologics and must be “highly similar” to them to be approved by the FDA. They must have no clinically meaningful differences from the biologic drug, and be just as safe, pure and potent. More than a decade after Congress created an approval pathway for biosimilars, they are widely accepted as safe and effective alternatives to brand biologics.

Medical experts hope that as biosimilars become more widely used they will increasingly provide a brake on drug spending.

From 2015 to 2019, drug spending overall grew 6.1%, while spending on biologics grew more than twice as much — 14.6% — according to a report by IQVIA, a health care analytics company. In 2019, biologics accounted for 43% of drug spending in the U.S.

Biosimilars provide a roughly 30% discount over brand biologics in the U.S. but have the potential to reduce spending by more than $100 billion in the next five years, the IQVIA analysis found.

In a survey of 602 physicians who prescribe biologic medications, more than three-quarters said they believed biosimilars are just as safe and effective as their biologic counterparts, according to NORC.

But they were less comfortable with switching patients from a brand biologic to a biosimilar. While about half said they were very likely to prescribe a biosimilar to a patient just starting biologic therapy, only 31% said they were very likely to prescribe a biosimilar to a patient already doing well on a brand biologic.

It can be challenging to find a treatment regimen that works for patients with complicated chronic conditions, and physicians and patients often don’t want to rock the boat once that is achieved.

In Moxley’s case, for example, before her condition stabilized on Remicade, she tried a conventional pill called Lialda, the biologic drug Humira and a lower dose of Remicade.

Some doctors and patients raise concerns that switching between these drugs might cause patients to develop antibodies that cause the drugs to lose effectiveness. They want to see more research about the effects of such switches.

“We haven’t seen enough studies about patients going from the biologic to the biosimilar and bouncing back and forth,” said Dr. Marcus Snow, chair of the American College of Rheumatology’s Committee on Rheumatologic Care. “We don’t want our patients to be guinea pigs.”

Manufacturers of biologic and biosimilar drugs have participated in advertising, exhibit or sponsorship opportunities with the American College of Rheumatology, according to ACR spokesperson Jocelyn Givens.

But studies show a one-time switch from Remicade to a biosimilar like Inflectra does not cause side effects or the development of antibodies, said Dr. Ross Maltz, a pediatric gastroenterologist at Nationwide Children’s Hospital in Columbus, Ohio, and former member of the Crohn’s & Colitis Foundation’s National Scientific Advisory Committee. Studies may be conducted by researchers with extensive ties to the industry and funded by drugmakers.

Situations like Moxley’s are unusual, said Kristine Grow, senior vice president of communications at AHIP, an insurer trade group.

“For patients who have been taking a brand-name biologic for some time, health insurance providers do not typically encourage them to switch to a biosimilar because of a formulary change, and most plans exclude these patients from any changes in cost sharing due to formulary changes,” she said.

Drugmakers can seek approval from the FDA of their biosimilar as interchangeable with a biologic drug, allowing pharmacists, subject to state law, to switch a physician’s prescription from the brand drug, as they often do with generic drugs.

However, the FDA has approved only one biosimilar (Semglee, a form of insulin) as interchangeable with a biologic (Lantus).

Like Moxley, many other patients using biologics get copay assistance from drug companies, but the money often isn’t enough to cover the full cost. In her old job as a radio reporter, Moxley said, she hit the $7,000 maximum annual out-of-pocket spending limit for her plan by May.

In her new job, Moxley has an individual plan with a $4,000 maximum out-of-pocket limit, which she expects to blow past once again within months.

But she received good news recently: Her new plan will cover Remicade.

“I’m still concerned that I will have developed antibodies since my last dose,” she said. “But it feels like a step in the direction of good health again.”

KHN (Kaiser Health News) is a national newsroom that produces in-depth journalism about health issues. Together with Policy Analysis and Polling, KHN is one of the three major operating programs at KFF (Kaiser Family Foundation). KFF is an endowed nonprofit organization providing information on health issues to the nation.

USE OUR CONTENT

This story can be republished for free (details).

Biosimilar Drugs Are Cheaper Than Biologics. Are They Similar Enough to Switch? published first on https://nootropicspowdersupplier.tumblr.com/

[stephenmccull]

Biosimilar Drugs Are Cheaper Than Biologics. Are They Similar Enough to Switch?

It took years for Elle Moxley to get a diagnosis that explained her crippling gastrointestinal pain, digestion problems, fatigue, and hot, red rashes. And after learning in 2016 that she had Crohn’s disease, a chronic inflammation of the digestive tract, she spent more than four years trying medications before getting her disease under control with a biologic drug called Remicade.

So Moxley, 33, was dismayed to receive a notice from her insurer in January that Remicade would no longer be covered as a preferred drug on her plan. Another drug, Inflectra, which the Food and Drug Administration says has no meaningful clinical differences from Remicade, is now preferred. It is a “biosimilar” drug.

“I felt very powerless,” said Moxley, who recently started a job as a public relations coordinator for Kansas City Public Schools in Missouri. “I have this decision being made for me and my doctor that’s not in my best interest, and it might knock me out of remission.”

After Moxley’s first Inflectra infusion in July, she developed a painful rash. It went away after a few days, but she said she continues to feel extremely fatigued and experiences gastrointestinal pain, constipation, diarrhea and nausea.

Many medical professionals look to biosimilar drugs as a way to increase competition and give consumers cheaper options, much as generic drugs do, and they point to the more robust use of these products in Europe to cut costs.

Yet the U.S. has been slower to adopt biosimilar drugs since the first such medicine was approved in 2015. That’s partly because of concerns raised by patients like Moxley and their doctors, but also because brand-name biologics have kept biosimilars from entering the market. The companies behind the brand-name drugs have used legal actions to extend the life of their patents and incentives that make offering the brand biologic more attractive than offering a biosimilar on a formulary, listing which drugs are covered on an insurance plan.

“It distorts the market and makes it so that patients can’t get access,” said Dr. Jinoos Yazdany, a professor of medicine and chief of the rheumatology division at Zuckerberg San Francisco General Hospital.

The FDA has approved 31 biosimilar medications since 2015, but only about 60% have made it to market, according to an analysis by NORC, a research organization at the University of Chicago.

Remicade’s manufacturer, Johnson & Johnson, and Pfizer, which makes the Remicade biosimilar Inflectra, have been embroiled in a long-running lawsuit over Pfizer’s claims that Johnson & Johnson tried to choke off competition through exclusionary contracts with insurers and other anti-competitive actions. In July, the companies settled the case on undisclosed terms.

In a statement, Pfizer said it would continue to sell Inflectra in the U.S. but noted ongoing challenges: “Pfizer has begun to see progress in the overall biosimilars marketplace in the U.S. However, changes in policy at a government level and acceptance of biosimilars among key stakeholders are critical to deliver more meaningful uptake so patients and the healthcare system at-large can benefit from the cost savings these medicines may deliver.”

Johnson & Johnson said it is committed to making Remicade available to patients who choose it, which “compels us to compete responsibly on both price and value.”

Biologic medicines, which are generally grown from living organisms such as animal cells or bacteria, are more complex and expensive to manufacture than drugs made from chemicals. In recent years, biologic drugs have become a mainstay of treatment for autoimmune conditions like Crohn’s disease and rheumatoid arthritis, as well as certain cancers and diabetes, among other conditions.

Other drugmakers can’t exactly reproduce these biologic drugs by following chemical recipes as they do for generic versions of conventional drugs.

Instead, biosimilar versions of biologic drugs are generally made from the same types of materials as the original biologics and must be “highly similar” to them to be approved by the FDA. They must have no clinically meaningful differences from the biologic drug, and be just as safe, pure and potent. More than a decade after Congress created an approval pathway for biosimilars, they are widely accepted as safe and effective alternatives to brand biologics.

Medical experts hope that as biosimilars become more widely used they will increasingly provide a brake on drug spending.

From 2015 to 2019, drug spending overall grew 6.1%, while spending on biologics grew more than twice as much — 14.6% — according to a report by IQVIA, a health care analytics company. In 2019, biologics accounted for 43% of drug spending in the U.S.

Biosimilars provide a roughly 30% discount over brand biologics in the U.S. but have the potential to reduce spending by more than $100 billion in the next five years, the IQVIA analysis found.

In a survey of 602 physicians who prescribe biologic medications, more than three-quarters said they believed biosimilars are just as safe and effective as their biologic counterparts, according to NORC.

But they were less comfortable with switching patients from a brand biologic to a biosimilar. While about half said they were very likely to prescribe a biosimilar to a patient just starting biologic therapy, only 31% said they were very likely to prescribe a biosimilar to a patient already doing well on a brand biologic.

It can be challenging to find a treatment regimen that works for patients with complicated chronic conditions, and physicians and patients often don’t want to rock the boat once that is achieved.

In Moxley’s case, for example, before her condition stabilized on Remicade, she tried a conventional pill called Lialda, the biologic drug Humira and a lower dose of Remicade.

Some doctors and patients raise concerns that switching between these drugs might cause patients to develop antibodies that cause the drugs to lose effectiveness. They want to see more research about the effects of such switches.

“We haven’t seen enough studies about patients going from the biologic to the biosimilar and bouncing back and forth,” said Dr. Marcus Snow, chair of the American College of Rheumatology’s Committee on Rheumatologic Care. “We don’t want our patients to be guinea pigs.”

Manufacturers of biologic and biosimilar drugs have participated in advertising, exhibit or sponsorship opportunities with the American College of Rheumatology, according to ACR spokesperson Jocelyn Givens.

But studies show a one-time switch from Remicade to a biosimilar like Inflectra does not cause side effects or the development of antibodies, said Dr. Ross Maltz, a pediatric gastroenterologist at Nationwide Children’s Hospital in Columbus, Ohio, and former member of the Crohn’s & Colitis Foundation’s National Scientific Advisory Committee. Studies may be conducted by researchers with extensive ties to the industry and funded by drugmakers.

Situations like Moxley’s are unusual, said Kristine Grow, senior vice president of communications at AHIP, an insurer trade group.

“For patients who have been taking a brand-name biologic for some time, health insurance providers do not typically encourage them to switch to a biosimilar because of a formulary change, and most plans exclude these patients from any changes in cost sharing due to formulary changes,” she said.

Drugmakers can seek approval from the FDA of their biosimilar as interchangeable with a biologic drug, allowing pharmacists, subject to state law, to switch a physician’s prescription from the brand drug, as they often do with generic drugs.

However, the FDA has approved only one biosimilar (Semglee, a form of insulin) as interchangeable with a biologic (Lantus).

Like Moxley, many other patients using biologics get copay assistance from drug companies, but the money often isn’t enough to cover the full cost. In her old job as a radio reporter, Moxley said, she hit the $7,000 maximum annual out-of-pocket spending limit for her plan by May.

In her new job, Moxley has an individual plan with a $4,000 maximum out-of-pocket limit, which she expects to blow past once again within months.

But she received good news recently: Her new plan will cover Remicade.

“I’m still concerned that I will have developed antibodies since my last dose,” she said. “But it feels like a step in the direction of good health again.”

KHN (Kaiser Health News) is a national newsroom that produces in-depth journalism about health issues. Together with Policy Analysis and Polling, KHN is one of the three major operating programs at KFF (Kaiser Family Foundation). KFF is an endowed nonprofit organization providing information on health issues to the nation.

USE OUR CONTENT

This story can be republished for free (details).

Biosimilar Drugs Are Cheaper Than Biologics. Are They Similar Enough to Switch? published first on https://smartdrinkingweb.weebly.com/

[adityarana1687-blog]

Ankylosing Spondylitis Market Projected To Have Valuation Worth USD 7.9 Billion By 2025

The global ankylosing spondylitis market size is expected to reach USD 7.9 billion by 2027 registering a CAGR of 8.3%, according to a new report by Grand View Research, Inc. Presence of a strong product pipeline is likely to accelerate market growth. For instance, the positive phase-2b results of UCB S.A. pipeline product, Bimekizumab, makes it a potential drug candidate to be launched in the market over the forecast period.

Pharmaceutical companies are aiming at label expansion and patent extension for maintaining their share in the market. In October 2017, Johnson & Johnson Services received approval for Simponi Aria for AS treatment for the treatment active psoriatic arthritis (PsA) or active ankylosing spondylitis (AS). Such advancements in therapy area are expected to have a positive effect on the market growth.

Furthermore, presence of favorable reimbursement policies is anticipated to propel the growth. For instance, in Canada (Ontario) under the province’s public drug program, Novartis AG announced the reimbursement of Cosentyx for the treatment of ankylosing ankylosis. According to an article published by Novartis AG, approximately 20 to 40% of patients fail to achieve sufficient clinical improvement on anti-TNF drugs, which provides opportunities for companies to develop novel and effective drugs.

Request a free sample copy or view report summary: Ankylosing Spondylitis Market Report

Ankylosing Spondylitis Market Report Highlights

Humira was the largest revenue-generating drug in 2019 and accounted for over 25% of the market share due to the favorable pricing and lack of biosimilar competition in North America

Cosentyx is estimated to be the fastest-growing segment due to its excellent clinical profile. In addition, the product is patent protected for ankylosing spondylitis till 2033 in U.S. till and 2030 in Europe

North America led the market in 2019 due to the presence of key biopharmaceutical & pharmaceutical companies and increased funding and research initiatives

Key companies are adopting strategies, such as product development, M&A, and regional expansion, to increase their market share

For instance, in January 2019, Samsung Bioepis Co., Ltd. announced the strategic partnership with 3SBio Inc. to expand its product portfolio in China

Ankylosing Spondylitis Market Segmentation

Grand View Research has segmented the global ankylosing spondylitis market based on drug and region:

Ankylosing Spondylitis Drug Outlook (Revenue, USD Million, 2016 - 2027)

Cosentyx

Humira

Simponi

Remicade

Enbrel

Cimzia

Others

Ankylosing Spondylitis Regional Outlook (Revenue, USD Million, 2016 - 2027)

North America

Europe

Asia Pacific

Latin America

Middle East & Africa

U.S.

Canada

U.K.

Germany

France

Italy

Spain

Japan

China

India

Australia

South Korea

Brazil

Mexico

Chile

Columbia

Argentina

South Africa

Saudi Arabia

UAE

List of Key Players of Ankylosing Spondylitis Market

AbbVie, Inc.

Amgen, Inc.

Pfizer, Inc.

Novartis AG

Eli Lilly and Company

UCB, Inc.

Johnson & Johnson Services, Inc.

Merck & Co., Inc.

About Grand View Research

Grand View Research, Inc. is a U.S. based market research and consulting company, registered in the State of California and headquartered in San Francisco. The company provides syndicated research reports, customized research reports, and consulting services. To help clients make informed business decisions, we offer market intelligence studies ensuring relevant and fact-based research across a range of industries, from technology to chemicals, materials and healthcare.

[soumyafwr]

https://zekond.com/read-blog/59032_remicade-biosimilar-market-share-overview-competitive-analysis-and-forecast-2031.html

Remicade Biosimilar Market Share, Overview, Competitive Analysis and Forecast 2031

[jesse-pinkman123]

U.S. Non-oncology Biopharmaceuticals Market Size Share Trends Forecast 2026

The U.S. Non-oncology Biopharmaceuticals Market, by Product Type (Biologics and Biosimilars), by Drug Class (Monoclonal Antibody, Enzyme Replacement Therapy, Erythropoietin, Interferon, Colony-stimulating Factor, Botulinum Toxin, Fusion Protein, Vaccines, Human Recombinant Insulin, Blood Factors, Human Growth Hormone, and Others), and by Disease Indication (Diabetes, Rheumatoid Arthritis, Psoriatic Arthritis, Multiple Sclerosis, Hemophilia, Anemia, Age-related Macular Degeneration, Hepatitis B, Cystic Fibrosis, Osteoporosis, Crohn’s Disease, Ulcerative Colitis, Psoriasis, Ankylosing Spondylitis, and Others (Cardiac Diseases and Others)), was valued at US$ 116.0 Bn in 2018 and is projected to exhibit a CAGR of 10.2% during the forecast period (2018–2026).

Factors such as increasing launch and approval of novel biopharmaceuticals and robust pipeline of biopharmaceutical products in late phase of clinical trial is expected to significantly drive the U.S. non-oncology biopharmaceuticals market growth. For instance, in October 2018, Leadiant Biosciences, Inc. received the U.S. Food and Drug Administration (FDA) approval for its Revcov (elapegademase-lvlr) injection in the U.S. Revcovi is a new enzyme replacement therapy (ERT) for the treatment of adenosine deaminase severe combined immune deficiency (ADA-SCID) in pediatric and adult patients. Furthermore, key players are involved in development and launch of novel biopharmaceuticals for new indications. For instance, in May 2018, Novartis announced that the U.S. FDA approved Aimovig (erenumab) for the preventive treatment of migraine in adults. Aimovig was the first human monoclonal antibody approved for treatment of migraine. In September 2018, Eli Lilly and Company, and Teva Pharmaceutical Industries Ltd. also received the U.S. FDA approval for Emgality (galcanezumab-gnlm) and AJOVY (fremanezumab-vfrm), respectively for the preventive treatment of migraine in adults. Launch of novel drugs for new indications is expected to support the U.S. non-oncology biopharmaceuticals market growth over the forecast period.

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Browse 35 Market Data Tables and 38 Figures spread through 224 Pages and in-depth TOC on U.S. Non-oncology Biopharmaceuticals Market, by Product Type (Biologics and Biosimilars), by Drug Class (Monoclonal Antibody, Enzyme Replacement Therapy, Erythropoietin, Interferon, Colony-stimulating Factor, Botulinum Toxin, Fusion Protein, Vaccines, Human Recombinant Insulin, Blood Factors, Human Growth Hormone, and Others), and by Disease Indication (Diabetes, Rheumatoid Arthritis, Psoriatic Arthritis, Multiple Sclerosis, Hemophilia, Anemia, Age-related Macular Degeneration, Hepatitis B, Cystic Fibrosis, Osteoporosis, Crohn’s Disease, Ulcerative Colitis, Psoriasis, Ankylosing Spondylitis, and Others (Cardiac Diseases and Others)) - U.S. Forecast to 2026.

Key players in the market are involved in strategic merger, collaboration, acquisition, and partnership for the development of novel biopharmaceuticals to expand its portfolio with strategic acquisition of any company. For instance, in October 2018, Teva Pharmaceutical Industries Ltd. and Celltrion, Inc. entered into an exclusive partnership to commercialize two of Celltrion’s mAb biosimilar candidates in the U.S. and Canada. In 2016, AbbVie Inc. acquired all rights from Boehringer Ingelheim (BI) for Risankizumab (BI 655066). Risankizumab is an anti-IL-23 monoclonal biologic antibody for psoriasis. Company is also evaluating the product for other indications such as Crohn’s disease, asthma, and psoriatic arthritis. Currently, it is in clinical phase 3. Furthermore, patent loss of blockbuster drugs such as Humira and launch of their biosimilars at low prices is expected to be a major factor negatively affecting the revenue generated by blockbuster drugs, which in turn is expected to negatively affect the overall U.S non-oncology biopharmaceutical market size and growth over the forecast period. For instance, in the recent past, various players such as Sandoz Inc., Boehringer Ingelheim GmbH, and Amgen Inc., received the U.S. FDA approval for biosimilar versions of AbbVie Inc.’s blockbuster drug, Humira (adalimumab) in the U.S. However, most of these companies have reached a settlement agreement with AbbVie Inc. to delay launch of Humira biosimilar up to 2023.

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Key Takeaways of the U.S. Non-oncology Biopharmaceuticals Market:

The U.S. non-oncology biopharmaceuticals market is expected to exhibit a CAGR of 10.2% during the forecast period (2018 – 2026), owing to increasing product launches and approvals, and robust pipeline of novel U.S. non-oncology biopharmaceuticals

The U.S. is the most lucrative economy for monoclonal antibodies, as most of the key players such as AbbVie Inc., Roche Holding AG, and Merck & Co. generate major revenue of their biological drugs from the U.S.

In the recent past, various blockbuster biologics such as Humira and Remicade lost patent in the U.S. market. Furthermore, various other high revenue generating biologics are expected to lose their patents in the near future. Loss of patents in the U.S. market offers lucrative opportunity to other players for development of biosimilars.

Key players in the market have lucrative opportunities to develop novel and innovative therapies for various rare diseases and target the underserved patients. Acts such as the Orphan Drug Act also supports in creating financial incentives for companies to develop new drugs for rare diseases.

Major players operating in the U.S. non-oncology biopharmaceuticals market include Sanofi S.A., Pfizer, Inc., Johnson & Johnson, Novartis International AG, Amgen, Inc., Eli Lilly and Company, AbbVie Inc., Bristol - Myers Squibb Company, F. Hoffmann-La Roche AG, Novo Nordisk A/S, GlaxoSmithKline plc., UCB Pharma, Teva Pharmaceutical Industries Ltd., Takeda Pharmaceutical Company Ltd, AstraZeneca Plc, Mylan N.V., LEO Pharma A/S, Boehringer Ingelheim GmbH, Alexion Pharmaceuticals Inc., Merck & Co., Inc. Elusys Therapeutics, Inc., Swedish Orphan Biovitrum AB, Samsung Bioepis NL B.V., Biogen Inc., and Theratechnologies Inc.

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Monoclonal Antibodies Market: Revenue Growth, Key Players, Qualitative Analysis, Forecast 2020-2028

The monoclonal antibody market is estimated to represent a global market of USD 135.6 billion by 2025 with growth rate of 4.8%. Biologics industry has been constantly on rise which strongly support the growth of monoclonal antibody market. Due to this fact, the utilization of monoclonal antibody has increased over the past few years owing to the increased awareness of these therapeutics among physicians and patients.For example, in 2012, approximately 20% of the total pharmaceutical revenue generated from biologic products and is anticipated to increase around 25% by the end of 2018. Furthermore, successful commercialization of monoclonal antibodies like Avastin, Rituxan and Remicade further boosted the customer base. For example, mAbs such as Avastin clocked more than US$ 6 billion of sale across the globe in 2013. Increasing uptake of these therapeutics support the market development. The market covers the analysis of the commercial or pipeline monoclonal antibody therapeutics such as Humira (adalimumab, anti-TNF), Enbrel, Remicade, Rituxan, Avastin, Herceptin, Lucentis, Erbitux, Eylea and many others.The global market is categorized in terms of source, end use and diseases. Based on source, the market is divided in murine, chimeric, humanized and human. Humanized and human segments are accounted for the largest share of the global market. Reason behind the high growth of this segments as these are considered as a natural drug and offers good safety on in vivo use.Synagis, Herceptin, Zenapax, Myelotarg, Campath, Xolair, Raptiva, Avastin, Tsyabri, Humira, Vectibix , and Cosentyx are some of the examples of human or humanized monoclonal antibodies. In terms of diseases, the market is segmented as autoimmune diseases, Inflammatory diseases, Infectious diseases and others. The utilization of monoclonal antibody therapeutics in cancer treatments and autoimmune diseases is whooping the market growth. Continuous rise in the incidence rate of cancer and autoimmune diseases along with growing demand for effective therapeutics in these area drive the market growth to great extent. End user segment is divided as hospitals, research laboratories and others. Hospitals segment dominated the market, captured almost 41.23% share of the global market in 2016.

Request to Fill The Form To get Sample Copy of This Report: https://www.sdki.jp/sample-request-53378 Regionally, developed regions such as North America and Europe are considered to be the largest market. Of which, North America accounted for almost 50% share of the global market in 2016. Increasing number of research and development activities coupled with rise in awareness among end users about monoclonal antibody drives the market growth. U.S. based Pfizer, Inc. is currently researching on avelumab—monoclonal antibody for indications such as non-small cell lung cancer, ovarian cancer, and others. These companies spenda significant share of their revenue on research activities, to develop novel mAbs. Europe is also considered to capture significant market share, 25% global share in 2016. Increasing approval of novel monoclonal antibodies is expected to stimulate the market demand. In 2012, European Medicines Agency (EMA) released guidelines on biosimilar mAb development. This guideline demonstrates the capability of biosimilar mAbs with an interest in development of similar biological mAbs, leading to drive market growth. Asia Pacific and Latin American countries are projected to grow with the promising growth rate during the future period. Companies such as F. Hoffmann-La Roche Ltd.; GlaxoSmithKline plc, Novartis AG; Pfizer; Shanghai Junshi Bioscience Co., Ltd, Daiichi Sankyo Company, Ltd., and others are operating in this market. These companies are engaged in strategic merger and acquisitions to expand their market share in this market. For example, Roche, Inc. acquired California based Genentech which has helped company to expand its market share in monoclonal antibody segment. Aside from Roche, Abbott Laboratories also exhibit strong potential in the monoclonal antibody sector. Growth of this company is attributed to its acquisition of Knoll Pharmaceutical Co. unit and licensing rights to MedImmune’s Synagis and Numax. Further, Johnson & Johnson enhance its market presence supported by the strong growth of Stelara (ustekinumab), Simponi (golimumab), and bapineuzumab. The market size and forecast for each segment has been provided for the period 2014 to 2025, considering 2015 as the base year. The report also provides the compounded annual growth rate (% CAGR) for the forecast period 2016 to 2025 for every reported segment. The years considered for the study are: Historical Year – 2014 & 2015 Base Year – 2015 Estimated Year – 2016 Projected Year – 2025 TARGET AUDIENCE Traders, Distributors, And Suppliers Hospitals Manufacturers Government and Regional Agencies and Research Organizations Consultants Distributors

SCOPE OF THE REPORT

The scope of this report covers the market by its major segments, which include as follows: MARKET, BY SOURCE Murine Chimeric Humanized Human MARKET, BY DISEASE Autoimmune diseases Inflammatory diseases Infectious diseases others MARKET, BY END USE Hospitals Research labs Others MARKET, BY REGION North America Europe Asia Pacific Rest of the World MARKET, BY COUNTRY Further Breakdown of The North America Market U.S. Canada Further Breakdown of The Europe Market Germany France Rest of Europe Further Breakdown of The APAC Market India China Rest of APAC Further Breakdown of The Rest of the World Market Middle-East and Africa Latin America

The dynamic nature of business environment in the current global economy is raising the need amongst business professionals to update themselves with current situations in the market. To cater such needs, Shibuya Data Count provides market research reports to various business professionals across different industry verticals, such as healthcare & pharmaceutical, IT & telecom, chemicals and advanced materials, consumer goods & food, energy & power, manufacturing & construction, industrial automation & equipment and agriculture & allied activities amongst others.

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Biosimilar of Remicade Market: Global Industry Analysis By Size, Share, Growth, Sourcing Strategy, Scope, Demand And Forecast To 2028

A new report on the Biosimilar of Remicade Market research study, published by Reports and Data, provides an in-depth survey of the dominant participants of the industry –the basis points for which are the financial highlights, company outline, SWOT Analysis, Product Portfolio, as well as major strategies and the expansion plans of the new and potential contenders. This report is also anticipated to reflect consistent growth in the coming years since consumers are now more aware of product quality. This market analysis of an industry is a crucial factor that numerous stakeholders, such as investors, traders, suppliers, and others, will find beneficial.

The research offered by the Biosimilar of Remicade report has been formulated through key analytical tools and extensive primary and secondary research further validated and verified by industry experts, industry professionals and analysts. The report includes SWOT analysis, Porter’s Five Forces analysis, feasibility analysis, and investment return analysis to impart better understanding of the Biosimilar of Remicade market dynamics. Key companies in the Biosimilar of Remicade market include: Janssen Biotech Inc., Merck &Co., Pfizer Inc. (AC. Hospira), Celltrion Inc., Alvogen, Napp Pharmaceuticals, and Nippon Kayaku are some major players in the global Remicade (infliximab  mAb) market.

Get a sample of the report @ https://www.reportsanddata.com/sample-enquiry-form/4029 For the purpose of this report, Reports and Data has segmented the Disposable Blood Pressure Cuffs market on the basis of Product Type, end use, and region:

Approved Indication Outlook (Revenue, USD Billion; 2018 – 2028)

Ulcerative Colitis

Rheumatoid Arthritis

Psoriatic Arthritis

Plaque Psoriasis

Crohn’s Disease

Ankylosing Spondylitis

Research findings and conclusion are offered through detail graphs, tables, charts, figures, and other pictorial representations. The report also includes a feasibility analysis and investment return analysis and aims to offer beneficial information that might help in formulating new business strategies and expansion plans. The report is a comprehensive overview of the industry, sales channel, distribution network, key strategies, growth prospects, drivers and restraints, and the key technological and product developments in the Biosimilar of Remicade market.

Ask for discount @ https://www.reportsanddata.com/discount-enquiry-form/4029 The report provides insights on the following pointers:

·         Market Penetration: Comprehensive information on the product portfolios of the top players in the Biosimilar of Remicade market.

·         Product Development/Innovation: Detailed insights on the upcoming technologies, R&D activities, and product launches in the market.

·         Competitive Assessment: In-depth assessment of the market strategies, geographic and business segments of the leading players in the market.

·         Market Development: Comprehensive information about emerging markets. This report analyzes the market for various segments across geographies.

·         Market Diversification: Exhaustive information about new products, untapped geographies, recent developments, and investments in the Biosimilar of Remicade market.

Key Questions Answered in this Research Study:

What     is the global production, production value and consumption value?

Who     are the global key manufacturers of the market? How are their operating     situation?

What     are the types and applications of market?

What     is the market share value of each type and application?

What     are the upstream raw materials and manufacturing equipment?

What     is the manufacturing process?

Economic     impact on the market and development trends of market.

What     will be the market size and the growth rate be in 2028?

What     are the key factors driving the market?

What     are the key market trends impacting the growth of the market?

What     are the challenges to market growth?

What     are the market opportunities and threats faced by the vendors in the     market?

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[marketinfo]

Remicade Biosimilar Market Size is Booming in Upcoming Years Due To Global Demand and Business-opportunities 2021-2028 | COVID-19 Impact & Recovery Analysis

Market Overview

Remicade Biosimilar

market is expected to be growing at a growth rate of 9.60% in the forecast period of 2021 to 2028. The Remicade Biosimilar market is going to gain a noticeable growth rate during the forecast period of 2021 to 2028 reaching a remarkable market size by 2028. The market has been studied taking into consideration the different factors which include the market drivers, restraints, opportunities, key competitor landscape, trend analysis, outlook, estimate, and forecast factors.

Methodology

The report presents considerable research and study based on objective information gathered from interviews with global experts and secondary data from research sources. The research has a certain objective of carrying out marketing efficiently. This research study involves the substantial usage of both primary and secondary data sources. Data Procurement, Data Synthesis, Market Deduction & Formulation, Data Validation & Market Feedback are some of the steps engaged in the research procedure. There is the execution of the bottom-up approach and top-down approach in the survey.

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Report Summary

Periodic reports in today’s organizational setup have become essential through which market condition is inspected thoroughly and various business rules are made to shape a lot of useful suggestions and solutions aimed at the advancement and betterment of the company. Organizations require a considerable amount of data and information on specific topics, scenarios, and situations. Managers and decision-makers often use business reports and research papers as information sources to make important business decisions and reach solutions. The main objective of a report prepared by us is to identify different growth opportunities to help the business to build a market leader ahead of competitors in the market.

Growth Mapping

The actual role of this report is to give a progressive guide report of the market and thus help the clients in a business set up to meet the business objectives. In this way, there are numerous subjective and quantitative factors utilized for the growth planning of the market. These include PESTEL examination for different areas associated with the market, SWOT investigation of the business, PORTER'S five powers for analysis of various traits, for example, the ability of the purchaser and provider occupied with the market, the danger of replacement, the force of competition, and the danger of the new participants in the market.

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● For making informed decisions in the businesses, it offers analytical data with strategic planning techniques. ● It offers a seven-year evaluation of Remicade Biosimilar Market. ● It helps in understanding the significant key product segments of the research industry. ● This report illuminates the dynamics of the market, for example, drivers, restraints, trends, and opportunities. ● It offers a regional analysis of Remicade Biosimilar market along with business profiles of several stakeholders in the research market.

Regional Analysis

Different regions such as North America, Latin America, the Asia-Pacific region, Europe, and India, China, and Australia have been analyzed on the basis of different indexes that would benefit the development of the market in the area. It contains the territorial as well as the nation level investigation of the market. It was observed that North America and Asia-pacific countries have shown impressive development opportunities in their region. Asia-Pacific nations due to such a large population could be the prime region for developing the fully flourishing market. However, Europe, being a region of most developed countries seems to be lagging in the survey due to its climatic-driven guidelines. Customization of reports: Various research approaches are initiated in order to prepare an elaborate, illustrated customized research report at a discounted price.

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U.S. NON-ONCOLOGY BIOPHARMACEUTICALS MARKET

Biologics can be defined as molecules derived from living cells such as microorganisms, plants or animal cells and used in the treatment, diagnosis or prevention of diseases. Most of the biologic molecules are very large, complex molecules or mixture of molecules.

Biopharmaceuticals are part of a wider category of therapeutic agents called biologics. Biopharmaceuticals are the substances developed in living systems with the help of biotechnology and are used in therapeutic and diagnostic applications. Non-oncology biopharmaceuticals are the drugs that are used in the treatment of various diseases rather than cancer such as rheumatoid arthritis, psoriatic arthritis, multiple sclerosis, hemophilia, age-related macular degeneration, osteoporosis, and others.

Increasing launches, approvals, and robust pipeline of novel biopharmaceuticals for non-oncology indications

Frequent approvals, launches, and robust pipeline of novel non-oncology biopharmaceuticals for various indications in the U.S. market is expected to significantly support the U.S. non-oncology biopharmaceuticals market growth.

For instance, in September 2018, Eli Lilly and Company received the U.S. Food and Drug Administration (FDA) approval for its Emgality (galcanezumab-gnlm) 120 mg injection, for the preventive treatment of migraine in adults.

In February 2018, Novartis announced that the U.S. Food and Drug Administration (FDA) approved a label update for its Cosentyx (secukinumab), the first interleukin-17A (IL-17A) inhibitor approved to treat moderate-to-severe plaque psoriasis.

In July 2018, Amgen Inc. and UCB Inc. resubmitted the Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for EVENITY (romosozumab), an investigational monoclonal antibody for the treatment of osteoporosis in postmenopausal women at high risk of fracture.

The U.S. non-oncology biopharmaceuticals market size was valued at US$ 116.0 Bn in 2018 and is expected to witness a CAGR of 10.2% during the forecast period (2018 – 2026).

Figure 1. U.S. Non-oncology Biopharmaceuticals Market Share (%), By Product Type, 2018-2026

                        Source: Coherent Market Insights Analysis (2018)

Increasing mergers and collaborations among key players for development of novel non-oncology biopharmaceuticals is expected to support the market growth

Key players in the market are involved in strategic mergers and collaborations for the development of new biopharmaceutical products and to market them in the U.S. Such strategic mergers and collaborations between key players is expected to support the development of novel products, which in turn is expected to fuel the U.S. non-oncology biopharmaceuticals market growth over the forecast period.

For instance, in 2017, Sanofi S.A. and its vaccines business unit Sanofi Pasteur collaborated with MedImmune, the global biologics research and development arm of AstraZeneca Plc., for the development and commercialization of a monoclonal antibody, namely MEDI8897, for the prevention of Respiratory Syncytial Virus (RSV) associated illness in newborns and infants.

High price of branded biologic products is expected to be a major factor negatively affecting its adoption

According to the report published by the Association for Accessible Medicines in 2018, the annual treatment with Humira comes with a list price of US$ 38,000, and according to the report published by I-Mak.org, between 2012 and 2016, the average spending on Humira per person in U.S. increased from US$ 16,000 to US$ 33,000.

Table 1. Revenue of Top Non-oncology Biopharmaceutical Brands in the U.S.

Source: Coherent Market Insights Analysis (2018)

Market Opportunity

In the recent past, various blockbuster biologics such as Humira and Remicade lost patent in the U.S. market. Furthermore, various other high revenue generating biologics are expected to lose their patents in the near future.

Loss of patent in the U.S. market offers lucrative opportunity to other players for development of its biosimilars. Hence, key players in the market are focused on launch and development of biosimilars of biologic products in the market at affordable price.

For instance, in 2017, Merck & Co., Inc. launched RENFLEXIS (infliximab-abda), a biosimilar of the originator biologic medicine Remicade (infliximab) by Janssen Biotech, Inc. As per the company, RENFLEXIS is introduced in the U.S. at a list price (wholesaler acquisition cost) of US$ 753.39, representing a 35% discount to the current list price of Remicade, which is its reference product.

Market Challenges

High R&D Investments: Developing an IV/injectable biopharmaceutical requires sophisticated infrastructure, skilled scientists, and significant resource investment. Development of a biopharmaceutical product requires extensive clinical research and multiple phases of trials, which is a lengthy and expensive process. These factors are significant barriers for the new players to enter the market.

Sales and Marketing: The U.S. non-oncology biopharmaceuticals market has established market players with strong sales and marketing team. Presence of such strong players in the country creates a big challenge for new players to enter the market and to sustain against such big players.

Physician Acceptance: Physician acceptance of substitutes for well-established products may be a challenge, particularly among indications for which numerous products are available and substitutes do not exhibit high/ better safety profile and/or lower cost.

Key players operating in the U.S. non-oncology biopharmaceuticals market include Sanofi S.A., Pfizer, Inc., Johnson & Johnson, Novartis International AG, Amgen, Inc., Eli Lilly and Company, AbbVie Inc., Bristol-Myers Squibb Company, F. Hoffmann-La Roche AG, Novo Nordisk A/S, GlaxoSmithKline plc., UCB Pharma, Teva Pharmaceutical Industries Ltd., Takeda Pharmaceutical Company Ltd, AstraZeneca Plc, Mylan N.V., LEO Pharma A/S, Boehringer Ingelheim GmbH, Alexion Pharmaceuticals Inc., Merck & Co., Inc., Elusys Therapeutics, Inc., Swedish Orphan Biovitrum AB, Samsung Bioepis NL B.V., Biogen Inc., and Theratechnologies Inc.

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[medicaldevicetech]

Size Of Seropositive Rheumatoid Arthritis Drug Market  Analysis by 2023

The seropositive rheumatoid arthritis drugs market is anticipated to proliferate in the coming years owing to the rising influence of biosimilars over the branded drugs along with the reducing cost of treatment for patients. Moreover, the arrival of new JAK inhibitors and BTK inhibitors could provide patients with oral treatments rather than taking their medications intravenously.

Seropositive Rheumatoid Arthritis Drug Market Regional Analysis:

The global seropositive rheumatoid arthritis drug market consists of regions namely the Americas, Europe, Asia Pacific, and the Middle East and Africa.

The Americas region holds the largest market for the global seropositive rheumatoid arthritis drug market is owing to the factors such as the increasing number of individuals suffering from the autoimmune disease. Seropositive rheumatoid arthritis is commonly occurring diseases in the U.S. that affect approximately 1.3 million Americans, according to Health Union LLC. Furthermore, the development of products by pharmaceutical companies for the treatment of rheumatoid arthritis is further influencing the growth of the global seropositive rheumatoid arthritis drug market.

Europe is the second largest market for the global seropositive rheumatoid arthritis drug market owing to the emerging oral therapies and rising demand for alternative biologics. Furthermore, the Asia Pacific region is anticipated to emerge as the fastest growing region and is expected to contend with the European market over the forecasted period. Furthermore, the developing nations hold potential opportunities for various key players to expand their regional presence.

Seropositive Rheumatoid Arthritis Drug Market Segmentation:

The global seropositive rheumatoid arthritis drug market is segmented on the basis of the drug class, drug, treatment and diagnosis, route of administration, application, and end user.

On the basis of the drug class, the global seropositive rheumatoid arthritis drug market is segmented into Non-steroidal anti-inflammatory drug type (NSAID), Steroids, and Disease-modifying anti-rheumatic drug type (DMARDs) and biologic agents.

On the basis of the drug, the global seropositive rheumatoid arthritis drug market is segmented into Humira (adalimumab), Enbrel (etanercept), Remicade (infliximab), Rituxan (rituximab), Actemra (tocilizumab), Orencia (abatacept), and others.

On the basis of the treatment, the global seropositive rheumatoid arthritis drug market is segmented into synovectomy, tendon repair, joint fusion and total joint replacement.

On the basis of the diagnosis, the global seropositive rheumatoid arthritis drug market is segmented into C - reactive protein (CRP) Test, CCP, ESR (Erythrocyte Sedimentation Rate) Test and Synovial Fluid Analysis.

On the basis of the route of administration, the global seropositive rheumatoid arthritis drug market is segmented into oral, subcutaneous, intravenous, and others.

On the basis of the application, the global seropositive rheumatoid arthritis drug market is segmented into medicine, scientific research, and others.

On the basis of the end user, the global seropositive rheumatoid arthritis drug market is segmented into hospital, diagnostic centers, ambulatory surgical centers, and others

Seropositive Rheumatoid Arthritis Drug Market Key Players:

Some of key the players in the global seropositive rheumatoid arthritis drug market are Abbott Laboratories (U.S.),  Johnson & Johnson Limited (U.S.), Novartis AG (Switzerland), Pfizer, Inc. (U.S.), and Eli Lilly and Company (U.S.), AbbVie Inc. (U.S.), Bristol-Myers Squibb Company (U.S.), F. Hoffmann-La Roche Ltd. (Switzerland), Amgen (U.S.), Vertex Pharmaceuticals Incorporated (U.S), Sanofi-Aventis (France), AstraZeneca (U.K), Cadila Healthcare Ltd. (India), GlaxoSmithKline Inc. (U.S.), Merck and Co. Inc. (U.S.) and others.

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Rheumatoid Arthritis Treatment Market - Global Industry Insights, Trends, Outlook, and Opportunity Analysis

Rheumatoid arthritis (RA) is the most common autoimmune arthritis affecting more than 1.3 million U.S. citizens (American College of Rheumatology). More surprising is to know that around 75% of this affected population is women. Affecting the joints at any age, rheumatoid arthritis needs to be addressed early to avoid expensive joint replacement surgery. While it can affect any joint, small joints in hand and feet tend to be affected the most. Treatments available for rheumatoid arthritis aids to relive symptoms and improve the joint function. A comprehensive treatment for RA usually involves integration of patient education, exercise, medications, and surgery (occasionally). The rheumatoid arthritis treatment market can be analyzed based on the drug type, as follows:

Monoclonal antibodies

IL-6 inhibitors

TNF inhibitors

NSAIDs and corticosteroid are also the first-line fast acting therapeutic drugs. Acetylsalicylate, naproxen, ibuprofen, etodolac, and diclofenac are the NSAIDs usually prescribed as first-line drugs for RA. These drugs reduce inflammation, and pain. Corticosteroid medications are given either orally or parenterally to reduce inflammation and restore joint mobility and function. These class of drugs are more potent than NSAIDs and therefore usually preferred a first line therapy by prescribers. The global rheumatoid arthritis treatment industry is expected to be driven considerably in near future by DMARDs that form second line slow-acting therapeutic drugs. Longer therapeutic regimen with these drugs increases cost of therapy and also promote remission of joint destruction and deformity. Methotrexate is the most commonly prescribed second line drug for RA and hence, occupies major share in the respective segment of global rheumatoid arthritis treatment market. Tofacitinib (Xeljanz) is the most potential FDA approved Janus kinase (JAK) inhibitor available in the global market of rheumatoid arthritis treatment.

https://www.coherentmarketinsights.com/ongoing-insight/rheumatoid-arthritis-treatment-market-166

FDA approved biologic drugs include rituximab (Rituxan, MabThera), abatacept (Orencia), adalimumab (Humira), etanercept (Enbrel), certolizumab (Cimzia), anakinra (Kineret), infliximab (Remicade), golimumab (Simponi), and tocilizumab (Actemra). Besides these approved drugs, biosimilars in pipeline would fuel the rheumatoid arthritis treatment market growth in near future.

Key statistics pertaining to the global rheumatoid arthritis treatment market:

Over time, there is damage to cartilage and mobility function of the affected joint in rheumatoid arthritis patient.

Affects nearly 1.3 million U.S. population (RheumatoidArthritis.org)

Most common in the age group of 30-60 years

Global prevalence varies in the range of 0.3% to 1% (World Health Organization)

Average annual cost of treatment may go up to US $20,000 (RheumatoidArthritis.org)

According to the Arthritis Foundation, people with RA loose more workdays compared to those affected by any other medical condition

According to a Harvard University study published in the Journal of Global Health (2017), prevalence of rheumatoid arthritis in Southeast Asian countries was 0.4%, 0.42 in western Pacific region, and 0.37% in eastern Mediterranean countries

Plethora of research work to introduce effective treatment therapies in the global rheumatoid arthritis treatment market

Introduction of newer therapies are expected to fuel growth of rheumatoid arthritis treatment market in developed nations. Emerging economies are late adapters to new technologies and therapies, thus are potential markets for brands not yet marketed in these countries. The Chinese FDA recently approved Xeljanz for RZ treatment (2017). The product is awaiting approval from the EU. Among the Asian countries, India, China, Pakistan, and Bangladesh had major prevailing rheumatoid arthritis patients as per WHO–ILAR COPCORD (International League of Associations for Rheumatology) (Community Oriented Program for Control of Rheumatic Diseases) studies (2015). Some of the products in pipeline include:

Antibodies that target collagen II, an important protein in joint cartilage (Researchers at the Department of Immunology, Genetics and Pathology, Uppsala University, Sweden)

Stem cell I.V. therapy developed by Mesoblast Ltd. to treat RA patients unresponsive to TNF drugs (phase 2 trials)

More of such developments by the market players will be a significant contributor towards the growth of global rheumatoid arthritis treatment industry.

Some of the major players in the global rheumatoid arthritis treatment market are Pfizer, Inc., Johnson & Johnson, Abbvie, Inc., F. Hoffmann-La Roche AG, Merck & Co., Inc., and Amgen, Inc.,

Key Developments

Major players in the market are focused on gaining product approvals to expand their product portfolio. For instance, in August 2019, AbbVie, a biopharmaceutical company, received the U.S. approval for RINVOQ (upadacitinib), an oral JAK Inhibitor for the treatment of moderate to severe rheumatoid arthritis.

Major institutes and universities are focused on research and development of novel therapies and technologies for the treatment of rheumatoid arthritis. For instance, in August 2019, researchers from the Kaohsiung Medical University, in the paper ‘Next-Generation Sequencing Profiles of the Methylome and Transcriptome in Peripheral Blood Mononuclear Cells of Rheumatoid Arthritis’ published in the journal MDPI Journal of Clinical Medicine, revealed a map to the peripheral blood mononuclear cells methylome and found that rheumatoid arthritis genetically associated genes and their interacting targets probably demonstrate differential methylation and differential expression than non-rheumatoid arthritis genetically associated genes.

Moreover, in August 2019, a team of researchers from the University of Groningen and University of Exeter Medical School suggested that Gal-9, a pleiotropic immunomodulatory protein probably promotes immunopathology in rheumatoid arthritis through its stimulatory effect on granulocytes.

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Crohn's Disease - Global Drug Forecast and Market Analysis to 2029 published on

https://www.sandlerresearch.org/crohns-disease-global-drug-forecast-and-market-analysis-to-2029.html

Crohn's Disease - Global Drug Forecast and Market Analysis to 2029

Crohn’s Disease – Global Drug Forecast and Market Analysis to 2029

Summary

Crohn’s disease (CD) is a form of inflammatory bowel disease (IBD), which is composed of two chronic autoimmune diseases that cause intestinal inflammation: Crohn’s disease (CD) and ulcerative colitis (UC). In CD, chronic inflammation may affect any part of the gastrointestinal (GI) tract from the mouth to the anal area; however, CD occurs most commonly in the lower part of the small intestine (ileum) and in the large intestine. The pathophysiology of CD is complex, as the disease is characterized by recurring flares that evolve along with periods of inactivity and remission. The CD market has historically been reliant on anti-tumor necrosis factor (anti-TNF) therapies that have been available for over a decade but recent developments have led to research on novel treatment mechanisms.

In May 2014, Takeda gained approval for Entyvio (vedolizumab), the first-in-class ?4?7 integrin inhibitor that was the first new biologic treatment approved for CD that was not an anti-TNF, and this was followed by Janssen’s Stelara (ustekinumab) in September 2016, which was a first-in-class interleukin (IL)-12 and 23 inhibitor. Moreover, biosimilars of currently marketed anti-TNF biologics recently entered the market, with Remicade (infliximab) biosimilars first marketed in 2015 in Europe and 2016 in the US, and adalimumab biosimilars first marketed in Europe in 2018. This is likely to result in a highly competitive market for patients who have failed first-line agents, such as steroids, aminosalicylates, and immunomodulators. Competition will intensify with the arrival of new anti-IL-23 treatments and new classes of therapies in development, Janus kinase (JAK) inhibitors and sphingosine-1-phosphate receptor (S1PR) modulators, which will offer a more convenient form of administration. With existing unmet need for all patients, particularly CD patients that experience loss of response to biologic treatment and patients that develop fistulizing disease, CD represents an important immunology sector for drug developers.

GlobalData estimates that sales of drugs in the CD market were approximately $7.4B in 2019 in the 8MM. The US was the largest market, with approximately $5.8B in drug sales, which represented 78.9% of the total CD market. The 5EU market contributed $1.3B in sales, Japan contributed sales of $133.2M, and Canada contributed sales of $148.9M in 2019. Global sales in the CD market are expected to grow to $12.6B by 2029, at a Compound Annual Growth Rate (CAGR) of 5.5% from 2019-2029. GlobalData forecasts the US CD market to grow to $10.4B (82.3% of global sales), the 5EU to grow to $1.9B (14.7% of global sales), Japan to grow to $174.9M (1.4% of global sales), and Canada to grow to $200.1M (1.6% of global sales) over the next 10 years.

Key Highlights

– The greatest driver of growth in the global CD market will be the launches of 11 pipeline therapies during the forecast period. The entry of these anticipated therapies, including AbbVie’s Skyrizi and Takeda’s subcutaneous Entyvio, will be subject to substantial uptake among moderate to severe CD patients. – The main barrier to growth in the CD market will be the patent expiry, and subsequent launch of biosimilars of Humira (adalimumab) in the US, and the launch of Entyvio and Stelara biosimilars across the 8MM. – The most important unmet needs in CD are the need for more efficacious and safe drugs and the inability to determine which treatment best suits each patient. The former is being addressed by the development of drugs with novel mechanisms of action, and the latter is being addressed by the discovery of new biomarkers. – The increasing diagnosed prevalence across the 8MM over the forecast period, rising from 0.16% in 2019 to 0.19% in 2029, which can be attributed to increased diagnosis in some markets, will lead to a greater CD patient pool eligible for treatment.

Key Questions Answered

– Over the forecast period, the CD market will see the entry of pipeline agents such as anti-IL-23 biologics, JAK inhibitors, and S1P receptor modulators, the sales of which will offset the loss of sales caused by the entry of biosimilars. How do products compete against each other? Which of these drugs will have the highest peak sales, and why? – Key Opinion Leaders (KOLs) interviewed by GlobalData have indicated that there are several unmet needs within the CD indication. What are the main unmet needs in this market? How can the pharmaceutical industry address these needs? To what degree will the therapies under development fulfill these unmet needs? – The CD market is likely to become a turbulent space throughout the forecast period and beyond. Which companies are set to be major players in CD during the forecast period?

Scope

– Overview of CD including epidemiology, etiology, pathophysiology, symptoms, diagnosis, and treatment guidelines. – Annualized CD therapeutics market revenue, annual cost of therapy and treatment usage pattern data from 2019 and forecast for ten years to 2029. – Key topics covered include strategic competitor assessment, market characterization, unmet needs, clinical trial mapping and implications for the CD therapeutics market. – Pipeline analysis: comprehensive data split across different phases, emerging novel trends under development, and detailed analysis of late-stage pipeline drugs. – Analysis of the current and future market competition in the global CD therapeutics market. Insightful review of the key industry drivers, restraints and challenges. Each trend is independently researched to provide qualitative analysis of its implications.

Reasons to Buy

The report will enable you to – – Develop and design your in-licensing and out-licensing strategies through a review of pipeline products and technologies, and by identifying the companies with the most robust pipeline. – Develop business strategies by understanding the trends shaping and driving the global CD therapeutics market. – Drive revenues by understanding the key trends, innovative products and technologies, market segments, and companies likely to impact the global CD therapeutics market in future. – Formulate effective sales and marketing strategies by understanding the competitive landscape and by analyzing the performance of various competitors. – Identify emerging players with potentially strong product portfolios and create effective counter-strategies to gain a competitive advantage. – Track drug sales in the global CD therapeutics market from 2019-2029. – Organize your sales and marketing efforts by identifying the market categories and segments that present maximum opportunities for consolidations, investments and strategic partnerships.