#Pruritus Therapeutics Industry

[healthcaretrends23]

Based on drug type, the corticosteroids segment accounted for around one-third of the overall pruritus therapeutics market in 2021, and is projected to lead the trail by the end of 2031. The same segment would cite the fastest CAGR of 4.4% throughout the forecast period. The report also discusses antihistamines, local anesthetics, immunosuppressant, and other segments.

[neha24blog]

Pruritus Therapeutics Market In-Depth Research On Basis By Product, Disease Type, Region And Forecast To 2025 : Grand View Research Inc.

San Francisco, 25 April 2023: The Report Pruritus Therapeutics Market By Product (Corticosteroids, Antihistamines, Local Anesthetics, Counterirritants, Immunosuppressant, Calcineurin Inhibitors, Pipeline, Unmet Needs), By Disease Type (Atopic Dermatitis, Allergic Contact Dermatitis, Urticaria) Analysis And Segment Forecasts To 2025 The global pruritus therapeutics market is expected to reach USD…

[imrreport]

Global Pruritus Therapeutics Projected To | HIT USD 16.37 Billion By 2028

Uncomfortable and irritating, itchy skin makes people want to scratch. Itchy skin, commonly known as pruritus, is frequently brought on by dry skin. Older people are more likely to experience it because as they age, their skin dries up. Depending on what is itching, the skin may appear normal, red, rough, or bumpy. Repeated scratching can cause thicker, elevated skin that may bleed or get infected. Numerous individuals find relief from self-care practises like routine moisturising, mild cleansers, and warm baths. The source of itchy skin must be identified and treated for long-term relief. Medical diseases include kidney failure, liver illness, thyroid disease, cancer, and diabetes can also contribute to pruritus.

Pruritus is treated with antibiotics, antifungals, anticonvulsants, and a few all-natural therapies including coconut oil, vitamin E, and honey applied topically. The two key reasons anticipated to propel the growth of the pruritus treatments market over the anticipated period are the rise in the number of people with chronic illnesses and the ageing population.

Read More: https://introspectivemarketresearch.com/reports/pruritus-therapeutics-market/ 

[marketinsight1234]

Pruritus Therapeutic Market: Forthcoming Trends and Share Analysis by 2030

The Pruritus Therapeutic market estimated at USD 12.64 Billion in the year 2022, is projected to reach a revised size of USD 17.84 Billion by 2030, growing at a CAGR of 4.4% over the analysis period 2023-2030.

The Pruritus Therapeutic Market is a segment within the broader healthcare industry that focuses on addressing itching, medically known as pruritus. Itching is a common symptom associated with various dermatological, systemic, and neurological conditions, ranging from mild discomfort to severe debilitation. The market encompasses a wide array of products and therapies aimed at relieving itching symptoms, managing underlying conditions, and improving patient quality of life.

Key components of the Pruritus Therapeutic Market include pharmaceuticals, topical treatments, medical devices, and emerging therapies. Pharmaceutical options range from antihistamines and corticosteroids to novel biologics and small molecule inhibitors targeting specific pathways involved in itch sensation. Topical treatments include creams, ointments, and lotions formulated with various active ingredients to alleviate itching and soothe irritated skin.

Medical devices such as phototherapy devices and wearable technologies offer alternative approaches to managing pruritus, while complementary therapies like acupuncture and hypnotherapy are also explored for their potential benefits. Additionally, advancements in understanding the neurobiology of itch have paved the way for targeted therapies that aim to modulate itch signals at the molecular level.

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Updated Version 2024 is available our Sample Report May Includes the:

Scope For 2024

Brief Introduction to the research report.

Table of Contents (Scope covered as a part of the study)

Top players in the market

Research framework (structure of the report)

Research methodology adopted by Worldwide Market Reports 

Moreover, the report includes significant chapters such as Patent Analysis, Regulatory Framework, Technology Roadmap, BCG Matrix, Heat Map Analysis, Price Trend Analysis, and Investment Analysis which help to understand the market direction and movement in the current and upcoming years. 

Leading players involved in the Pruritus Therapeutic Market include:

GlaxoSmithKline (GSK) (UK), Pfizer (USA), Sanofi (France), Bayer (Germany), AstraZeneca (UK), Asana BioSciences (USA), Vanda Pharmaceuticals (USA), Trevi Therapeutics (USA), Lumosa Therapeutics (USA), Shandong Boan Biotechnology (China), Titan Pharmaceuticals (USA), Teikoku Pharma Solutions (Japan), Tioga Pharmaceuticals (USA) 

Market Driver:

One significant driver propelling the Pruritus Therapeutic Market is the increasing prevalence of chronic skin conditions worldwide. Factors such as environmental pollutants, lifestyle changes, and genetic predispositions contribute to the rising incidence of dermatological ailments accompanied by pruritus. As awareness grows and diagnostic techniques advance, more individuals seek relief, fueling the demand for effective pruritus therapies.

Market Opportunity:

An emerging opportunity within the Pruritus Therapeutic Market lies in the development of targeted biologic treatments. Biologics offer a promising avenue for managing pruritus by addressing underlying inflammatory pathways and immune dysregulation. With ongoing research into novel biologic agents and personalized medicine approaches, there's potential for innovative therapies tailored to specific pruritic conditions. This presents an opportunity for pharmaceutical companies to diversify their portfolios and meet the unmet needs of patients with refractory pruritus.

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Segmentation of Pruritus Therapeutic Market:           

By Drug Class

Calcineurin Inhibitors

Corticosteroids

Counterirritants

Immunosuppressant

Antihistamines

By Disease Type

Allergic Contact Dermatitis

Atopic Dermatitis

Psoriasis

Urticaria

By Route Of Administration

Oral

Parenteral

Topical

By Regions: -

North America (US, Canada, Mexico)

Eastern Europe (Bulgaria, The Czech Republic, Hungary, Poland, Romania, Rest of Eastern Europe)

Western Europe (Germany, UK, France, Netherlands, Italy, Russia, Spain, Rest of Western Europe)

Asia Pacific (China, India, Japan, South Korea, Malaysia, Thailand, Vietnam, The Philippines, Australia, New Zealand, Rest of APAC)

Middle East & Africa (Turkey, Bahrain, Kuwait, Saudi Arabia, Qatar, UAE, Israel, South Africa)

South America (Brazil, Argentina, Rest of SA)

Highlights from the report:

Market Study: It includes key market segments, key manufacturers covered, product range offered in the years considered, Global Pruritus Therapeutic Market, and research objectives. It also covers segmentation study provided in the report based on product type and application.

Market Executive Summary: This section highlights key studies, market growth rates, competitive landscape, market drivers, trends, and issues in addition to macro indicators.

Market Production by Region: The report provides data related to imports and exports, revenue, production and key players of all the studied regional markets are covered in this section.

Pruritus Therapeutic Market Profiles of Top Key Competitors: Analysis of each profiled Roll Hardness Tester market player is detailed in this section. This segment also provides SWOT analysis of individual players, products, production, value, capacity, and other important factors.

If you require any specific information that is not covered currently within the scope of the report, we will provide the same as a part of the customization.

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About us:

Introspective Market Research (introspectivemarketresearch.com) is a visionary research consulting firm dedicated to assisting our clients to grow and have a successful impact on the market. Our team at IMR is ready to assist our clients to flourish their business by offering strategies to gain success and monopoly in their respective fields. We are a global market research company, that specializes in using big data and advanced analytics to show the bigger picture of the market trends. We help our clients to think differently and build better tomorrow for all of us. We are a technology-driven research company, we analyse extremely large sets of data to discover deeper insights and provide conclusive consulting. We not only provide intelligence solutions, but we help our clients in how they can achieve their goals.

Contact us:

Introspective Market Research

3001 S King Drive,

Chicago, Illinois

60616 USA

Ph no: +1-773-382-1049

Email: sales@introspectivemarketresearch.com

[imr1234]

The Global Pruritus Therapeutics Market: An Exclusive Study On Upcoming Trends And Growth Opportunities from 2022-2028

The global Pruritus Therapeutics Market was estimated at USD 12.11 billion in 2021 and is projected to reach USD 16.37 billion by 2028, growing at a CAGR of 4.4% over the analysis period.

Itchy skin is an uncomfortable, annoying sensation that causes individuals to scratch. Dry skin is a common cause of itchy skin, also known as pruritus. It's more frequent in older people since their skin dries out with age. The skin may appear normal, red, rough, or bumpy depending on the reason for the itching. Scratching repeatedly can result in raised, thickened skin that might bleed or become infected. Many people find relief from self-care methods such as frequent moisturizing, gentle cleansers, and lukewarm baths. Long-term relief requires determining and treating the source of itchy skin. Pruritus can also be caused by medical conditions such as kidney failure, liver disease, thyroid disease, cancer, and diabetes. Antibiotics, antifungals, anticonvulsants, and a few natural remedies such as topical application of coconut oil, vitamin E, and honey are utilized to treat pruritus.

The Pruritus Therapeutics report offers a better understanding of the market, which aids in the development of products and marketing initiatives to more precisely target the target market. A market research report can decrease risk and save time and money. This business report will be highly beneficial for increasing the company's industry expertise, developing new advertising and marketing strategies, and identifying the demographics that need to be targeted. In order to ensure that businesses are effectively receiving the crucial information required, the Pruritus Therapeutics market report has the best research offerings and the necessary expertise. This is true regardless of whether businesses are looking for new product trends or competitive analysis of an existing or emerging market.

Read More: https://introspectivemarketresearch.com/reports/pruritus-therapeutics-market/

[rameshjadhav]

The Global Pruritus Therapeutics Market: An Exclusive Study On Upcoming Trends And Growth Opportunities from 2022-2028

The global Pruritus Therapeutics Market was estimated at USD 12.11 billion in 2021 and is projected to reach USD 16.37 billion by 2028, growing at a CAGR of 4.4% over the analysis period.

Itchy skin is an uncomfortable and annoying sensation that causes people to scratch. Dry skin is a common cause of itchy skin, also known as pruritus. It is more common in older people as their skin dries up with age. The skin can appear normal, red, rough, or bumpy, depending on the reason for the itching. Repeated scratching can cause the skin to rise and thicken, which could bleed or become infected. Many people find relief with self-care methods such as frequent moisturizing, gentle cleansers, and warm baths. Long-term relief requires determining and treating the source of the itchy skin. Itching can also be caused by medical conditions like kidney failure, liver disease, thyroid disease, cancer, and diabetes. Antibiotics, antifungals, anticonvulsants, and some natural remedies such as topical application of coconut oil, vitamin E, and honey are used to treat the itching

The research goes into detail on the elements that drive market growth, including significant opportunities, growth drivers, as well as opportunities. Furthermore, it builds on previous data and the present business environment to forecast the industry's performance from 2020 to 2025. The study includes an extensive analysis of the workings of this business industry at regional and country levels in order to assess the industry size at a global level. Further, the study literature examines the dominating actors and assesses the techniques they use to maintain their position in the competitive arena. The present and predicted impact of the Covid-19 epidemic has also been considered, with a particular focus on income-generating opportunities and techniques to deal with the shifting situation

Read More: https://introspectivemarketresearch.com/reports/pruritus-therapeutics-market/

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U.S Outdoors Advertising Market 2022 - Global Industry Analysis 2022-2030#

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[newsupdate-1]

Pruritus Therapeutics Market Overview, Emerging Trends, Opportunities, Forecast

The most recent analysis on the Pruritus Therapeutics market provides a comprehensive review of all the important factors expected to drive market growth, including major drivers, constraints, market share, industry volume, recent trends, major breakthroughs, emerging opportunities, and future scope. The report's most crucial outcome for new market entrants includes a market-specific study, successful working strategies, key developments in the industrial sector, and major activities of leading players to persist in the market. This comprehensive research report includes a full market analysis as well as a market expert's opinion from the standpoint of the current market position and future projections.

Pruritus, also known as itch disorder can be triggered by several ailments ranging from dermatological disorders such as mycoses, atopic dermatitis, chickenpox, and contact dermatitis, Pruritus is interrelated with the dermatologic and systemic causes. A typical itching generally forms the diagnosis of a key dermatologic syndrome. Several skin diseases that are related to pruritus include renal pruritus, hematologic pruritus, cholestatic pruritus, idiopathic generalized pruritus, pruritus related to malignancy and endocrine pruritus.

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Competitive Landscape of Pruritus Therapeutics Market

For conducting extensive analysis, the study used a balanced mix of primary and secondary research approaches. The study includes market shares, production capacity, growth rates, product launches, and future projects for the major firms in the industry. It addresses the critical market elements that must be considered during strategic planning for both existing and new competitors in the Pruritus Therapeutics market. The prominent players present in the market are: (Allergan Inc., Amgen Inc., Astellas Pharma Inc., CARA Therapeutics, Novartis AG, and Teva Pharmaceutical Industries Ltd. among others.).

Market Segmentation

The global pruritus therapeutics market is segmented on the basis of product, disease type, and geography. On the basis of product, the global pruritus therapeutics market is segmented into Corticosteroids, Antihistamines, Local Anesthetics, Counterirritants, Immunosuppressant, Calcineurin Inhibitors, and Others. In 2017, the corticosteroids are expected to dominate the market by product segment as corticosteroids are widely used as the first line of treatment. On the basis of disease type, the global pruritus therapeutics market is segmented into Atopic Dermatitis, Allergic Contact Dermatitis, Urticaria, and Others. In 2017, Allergic contact dermatitis is estimated to dominate the market segment. It is the 3rd most general cause for patients seeking consultation with a dermatology specialist. Allergic contact dermatitis is commonly observed in women.

COVID-19 Impact Analysis

With detailed research, the research report discusses the influence of the COVID-19 pandemic on the Pruritus Therapeutics market growth. This study will serve as an ideal roadmap for market players to devise strategies to overcome the negative effects of COVID-19 and seize the market's current prospects. This section is included in the report to give market readers a clear picture of the market environment throughout the pandemic period, as well as estimates for the post-pandemic condition. All readers, as well as stakeholders, vendors, and purchasers, will obtain a thorough grasp of the market on a domestic and worldwide level as a result of this in-depth market analysis.

Regional Analysis

The market research also sheds light on the regional analysis of the global Pruritus Therapeutics market, as well as a detailed examination of the different factors that enable specific regional markets to dominate the industry. The report forecasts total sales growth in several regions, as well as market development at the country level. The report's regional market study will aid readers in comprehending market reach in various regions. This section of the research will help players find untapped potential markets and extend their business in these lucrative regions to expand their customer base.

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Reasons to Purchase this Report

·         Analysis at the domestic and country-level that sheds light on the demand and supply aspects that are largely driving the Pruritus Therapeutics market's growth.

·         A competitive landscape that includes firm profiles with essential financial data, a SWOT analysis, product offerings, recent developments, and strategies used.

·         Comprehensive market analysis, including key drivers, restraints, growth rate, current trends, and potential prospects.

·         Market segmentation analysis, which includes both quantitative and qualitative research, as well as the impact of policy and economic factors.

Customization of the Report

The report on the target market can be customized as per your specific requirements to fulfill the desired goals. Please get in touch with our team to get access to the most authentic report on the market. https://www.polarismarketresearch.com/industry-analysis/global-pruritus-therapeutics-market/request-for-customization

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[neha24blog]

Pruritus Therapeutics Market Expected To Witness A Substantial Growth Of USD 16.38 Billion By 2025: Grand View Research Inc.

San Francisco, 23 March 2020 : The Report Pruritus Therapeutics Market By Product (Corticosteroids, Antihistamines, Local Anesthetics, Counterirritants, Immunosuppressant, Calcineurin Inhibitors, Pipeline, Unmet Needs), By Disease Type (Atopic Dermatitis, Allergic Contact Dermatitis, Urticaria) Analysis And Segment Forecasts To 2025

Global pruritus therapeutics market is expected to reach USD…

[imrreport]

Global Pruritus Therapeutics Projected To Reach USD 16.37 Billion By 2028.

Pruritus skin is an uncomfortable and embarrassing feeling that makes people scratch. Dry skin is a common cause of itching, also known as itching. It is more common in the elderly because the skin dries out with age. The skin may look normal, red, rough or bumpy, depending on the cause of the itching. Repeated scratching can cause raised, thickened skin that can bleed or become infected. Many people find relief through self-care methods, such as frequent moisturizing creams, gentle cleansers, and warm baths. For long-lasting relief, it is necessary to identify and treat the cause of the itchy skin. Itching can also be caused by medical conditions such as kidney failure, liver disease, thyroid disease, cancer and diabetes.

Read more: https://introspectivemarketresearch.com/reports/pruritus-therapeutics-market/ 

[marketinsight1234]

Pruritus Therapeutic Market: Forthcoming Trends and Share Analysis by 2030

The Pruritus Therapeutic market estimated at USD 12.64 Billion in the year 2022, is projected to reach a revised size of USD 17.84 Billion by 2030, growing at a CAGR of 4.4% over the analysis period 2023-2030.

Dry skin is a common cause of itchy skin, also known as pruritus. It's more frequent in older people since their skin dries out with age. Antibiotics, antifungals, anticonvulsants, and a few natural remedies such as topical application of coconut oil, vitamin E, and honey are utilized to treat pruritus.

Innovations in drug development and increasing awareness about pruritus as a standalone condition or a symptom of other diseases were driving the market. Topical corticosteroids, antihistamines, and immunosuppressants were among the commonly prescribed treatments, while research efforts were underway to identify new therapeutic targets.

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The latest research on the Pruritus Therapeutic market provides a comprehensive overview of the market for the years 2023 to 2030. It gives a comprehensive picture of the global Pruritus Therapeutic industry, considering all significant industry trends, market dynamics, competitive landscape, and market analysis tools such as Porter's five forces analysis, Industry Value chain analysis, and PESTEL analysis of the Pruritus Therapeutic market. Moreover, the report includes significant chapters such as Patent Analysis, Regulatory Framework, Technology Roadmap, BCG Matrix, Heat Map Analysis, Price Trend Analysis, and Investment Analysis which help to understand the market direction and movement in the current and upcoming years. The report is designed to help readers find information and make decisions that will help them grow their businesses. The study is written with a specific goal in mind: to give business insights and consultancy to help customers make smart business decisions and achieve long-term success in their particular market areas.

Leading players involved in the Pruritus Therapeutic Market include:

GlaxoSmithKline (GSK) (UK), Pfizer (USA), Sanofi (France), Bayer (Germany), AstraZeneca (UK), Asana BioSciences (USA), Vanda Pharmaceuticals (USA), Trevi Therapeutics (USA), Lumosa Therapeutics (USA), Shandong Boan Biotechnology (China), Titan Pharmaceuticals (USA), Teikoku Pharma Solutions (Japan), Tioga Pharmaceuticals (USA) 

If You Have Any Query Pruritus Therapeutic Market Report, Visit:

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Segmentation of Pruritus Therapeutic Market:           

By Drug Class

Calcineurin Inhibitors

Corticosteroids

Counterirritants

Immunosuppressant

Antihistamines

By Disease Type

Allergic Contact Dermatitis

Atopic Dermatitis

Psoriasis

Urticaria

By Route Of Administration

Oral

Parenteral

Topical

By Regions: -

North America (US, Canada, Mexico)

Eastern Europe (Bulgaria, The Czech Republic, Hungary, Poland, Romania, Rest of Eastern Europe)

Western Europe (Germany, UK, France, Netherlands, Italy, Russia, Spain, Rest of Western Europe)

Asia Pacific (China, India, Japan, South Korea, Malaysia, Thailand, Vietnam, The Philippines, Australia, New Zealand, Rest of APAC)

Middle East & Africa (Turkey, Bahrain, Kuwait, Saudi Arabia, Qatar, UAE, Israel, South Africa)

South America (Brazil, Argentina, Rest of SA)

Highlights from the report:

Market Study: It includes key market segments, key manufacturers covered, product range offered in the years considered, Global Pruritus Therapeutic Market, and research objectives. It also covers segmentation study provided in the report based on product type and application.

Market Executive Summary: This section highlights key studies, market growth rates, competitive landscape, market drivers, trends, and issues in addition to macro indicators.

Market Production by Region: The report provides data related to imports and exports, revenue, production and key players of all the studied regional markets are covered in this section.

Pruritus Therapeutic Market Profiles of Top Key Competitors: Analysis of each profiled Roll Hardness Tester market player is detailed in this section. This segment also provides SWOT analysis of individual players, products, production, value, capacity, and other important factors.

If you require any specific information that is not covered currently within the scope of the report, we will provide the same as a part of the customization.

Acquire This Reports: -

https://introspectivemarketresearch.com/checkout/?user=1&_sid=16231

About us:

Introspective Market Research (introspectivemarketresearch.com) is a visionary research consulting firm dedicated to assisting our clients to grow and have a successful impact on the market. Our team at IMR is ready to assist our clients to flourish their business by offering strategies to gain success and monopoly in their respective fields. We are a global market research company, that specializes in using big data and advanced analytics to show the bigger picture of the market trends. We help our clients to think differently and build better tomorrow for all of us. We are a technology-driven research company, we analyse extremely large sets of data to discover deeper insights and provide conclusive consulting. We not only provide intelligence solutions, but we help our clients in how they can achieve their goals.

Contact us:

Introspective Market Research

3001 S King Drive,

Chicago, Illinois

60616 USA

Ph no: +1-773-382-1049

Email: sales@introspectivemarketresearch.com

[nuttydefendoryouth]

Practical Uses of Botanicals in Skin Care

Cosmeceuticals are the fastest growing sector of the cosmetic industry, and the future of antiaging cosmeceuticals in particular is very promising. Botanical pesticide that support the health, texture, and integrity of the skin, hair, and nails are widely used in cosmetic formulations. They form the largest category of cosmeceutical additives found in the marketplace today due to the rising consumer interest and demand for natural products. Various plant extracts that formed the basis of medical treatments in ancient civilizations and many traditional cultures are still used today in cleansers, moisturizers, astringents, and many other skin care products. New botanical skin care treatments are emerging, presenting dermatologists and their patients the challenge of understanding the science behind these cosmeceuticals. Thus, dermatologists must have a working knowledge of these botanicals and keep up with how they evolve to provide optimal medical care and answer patient questions. The most popular botanicals commonly incorporated into skin care protocols are discussed.

The cosmeceutical market is one of constant fluctuation depending upon consumer demand. Skin care companies are continuously pressured to release new, innovative products that promise to transform the appearance of aging skin overnight. Over the past decade, there has been fervent interest in products found in nature because of their perceived safety. Skin care products are often developed from plants. Many believe that if a product can be safely ingested, it will also be safe for topical application. In general, plant-derived, botanical feed additives, cosmeceutical products tend to be antioxidant in action since these organisms must thrive in constant direct ultraviolet (UV) light, the Earth's most prolific manufacturer of free radicals. In this article, the authors review the most popular ingredients in this class and comment on their possible usefulness in skin care protocols.

Soy extract has positive research support for its antioxidant, antiproliferative, and anticarcinogenic activities. Topical application of soy has been used to reduce hyperpigmentation, enhance skin elasticity, control oil production, moisturize the skin, and delay hair regrowth.1 Soy also has the potential to decrease photoaging of the skin and prevent skin cancers through the estrogen-type and antioxidant effects of its metabolites.1

The major components of soy are phospholipids, such as phosphatidylcholine and essential fatty acids. The minor components of soy include the most active compounds, such as isoflavones, saponins, essential amino acids, phytosterols, calcium, potassium, iron, and proteases soybean trypsin inhibitor (STI) and Bowman-Birk inhibitor (BBI). The various components of soy have a variety of beneficial effects making them useful additions to skin care products. The most potent isoflavones are the phytoestrogens known as genistein and daidzein. Genistein is a potent antioxidant that inhibits lipid peroxidation and chemical and ultraviolet light B (UVB)-induced carcinogenesis. Genistein was shown to significantly inhibit chemical, carcinogen-induced, reactive oxygen species; oxidative DNA damage; and proto-oncogene expression, as well as the initiation and promotion of skin carcinogenesis in mouse skin.2 Topical estrogens have been shown to promote collagen synthesis and increase skin thickness, which may be beneficial for postmenopausal women who develop a thinner dermis and decreased collagen.3 The small proteases STI and BBI appear to promote skin lightening and reduce unwanted facial and body hair in human clinical trials.3,4 Beyond the depigmenting activity, STI, BBI, and soy milk were also found to prevent UV-induced pigmentation both in vitro and in vivo.5 In addition, soy lipids, lecithins, and phytosterols are believed to restore barrier function and replenish moisture.

Beyond its moisturizing ability, soy appears to be a safe and effective treatment for postmenopausal women and for hyperpigmentation disorders (other than melasma, which is somewhat estrogen mediated). Although further research is necessary, the antioxidant and anticarcinogenic activities of soy and its isoflavones show a promising role for this botanical fertilizer additives in the cosmeceutical industry. Soy has therefore become a popular addition to a wide variety of skin care products (see Table 1).

Green tea extracts are among the fastest-growing herbal products. While there has been enormous growth in green tea consumption as a dietary supplement, the use of tea extracts in cosmeceutical formulations is also on the rise. The complex polyphenolic compounds in tea provide the same protective effect for the skin as for internal organs. They have been shown to modulate biochemical pathways that are important in cell proliferation, inflammatory responses, and responses of tumor promoters.6 Green tea has been shown to have anti-inflammatory and antioxidant effects in both human and animal skin.

Since inflammation and oxidative stress appear to play a significant role in the aging process, green tea may also have antiaging effects by decreasing inflammation and scavenging free radicals. Researchers have found that the main active ingredient in green tea, epigallocatechin-3-gallate (EGCG), works well as an anti-inflammatory, antioxidant, and sunscreen. Topical green tea applied to human skin has been shown to provide a photoprotective effect, reduce the number of sunburn cells, protect epidermal Langerhans cells from UV damage, and reduce the DNA damage that formed after UV radiation.7 Green tea polyphenols, when combined with traditional sunscreens, may have an additive or synergistic photoprotective effect. Green tea has also been found to decrease melanoma cells in tissue culture and squamous cell carcinoma cell formation in mice with topical and oral administration. Additionally, it improves wound healing by increasing keratinocyte cell differentiation and has been shown to inhibit Streptococcus species and Escherichia coli.8

Natural flavonoids, such as green or black tea polyphenols have been show to reduce UVB-induced erythema, tumorigenesis, and immunosuppression in mice.9,10 White tea appears to be a more potent antioxidant than green tea. Black tea has a much lower content of catechins than green tea, but a higher content of other flavonoids, such as quercetin, theaflavin, and kaempferol. Black tea extracts applied before and after UV light challenge have been shown to decrease signs of cutaneous photodamage, carcinogenesis, and inflammation in human and mouse skin.3

Most cosmeceutical products containing tea extracts or phenols have not been tested in controlled clinical trials, but these substances have shown compelling evidence for antioxidant, anti-inflammatory, and anticarcinogenic activities. There are currently several products that contain green tea extract on the market (see Table 2). Unfortunately, the concentration of phenols is not standardized in these products; therefore, some products may have little-to-no therapeutic effect, making purchasing them a challenge for consumers. It is generally accepted that five-percent green tea extract or polyphenols in the 90-percent range is an effective concentration.

German chamomile, or Matricaria recutita, has been used throughout history as an herbal treatment for various skin conditions. It functions as an antimicrobial, antiallergic, anti-inflammatory, antioxidant, and analgesic and was approved by the German Commission E for inflammatory mucocutaneous diseases and wound and burn therapy.3 The active constituents of chamomile include the terpenoids (bisoprolol, matricine, levomenol, chamazulene), flavonoids (apigenin, luteolin, rutin, quercetin), hydroxycoumarins, mono- and oligosaccharides, and mucilages. Chamazulene exhibits anti-inflammatory activity and promotes wound healing. Levomenol is an anti-inflammatory and natural moisturizing agent that has been found to diminish the signs of photodamage, reduce pruritus, and ameliorate skin texture and elasticity. In addition to reports of anti-inflammatory effects, chamomile is also purported to have some antioxidant properties, which have been identified through chemical assays.11,12

While chamomile is generally considered a safe product, there have been reports of contact dermatitis and conjunctivitis following topical application of chamomile products, and there is a potential risk of angioedema and anaphylaxis. Chamomile can also interact with warfarin, promoting an additive anticoagulant effect.

Clinical studies appear to support the traditional uses and therapeutic benefit of topical chamomile. This herb has been included in a wide variety of cosmetic products including soothing moisturizers and cleansers as well as color-enhancing hair products (see Table 3).

Caffeine, the chemical pesticide in coffee, tea, and some soft drinks, has demonstrated both anticarcinogenic and antioxidant properties. Initially, caffeine's potential inhibitory role in cancer development was found through studying oral administration of black and green tea.13 This study illustrated that the oral administration of caffeine alone and the addition of caffeine to decaffeinated teas showed inhibitory effects of UVB-induced carcinogenesis. Oral administration of caffeine has also been associated with in-vivo upregulation of tumor suppressor genes.14

Continued research revealed that topical application of caffeine inhibits carcinogenesis and promotes apoptosis in sunburn cells of hairless SKH-1, UVB-pretreated mice.15 Researchers found that topical application of the tea constituents caffeine and (-)-epigallocatechin gallate (EGCG) decreased the number of nonmalignant and malignant skin tumors in SKH-1 hairless mice pretreated with UVB. While caffeine performed better than EGCG, both treatments resulted in elevated apoptosis in nonmalignant skin tumors and squamous cell carcinomas. The results suggest a need for further studies to determine whether topical applications of caffeine or EGCG can inhibit sunlight-induced skin cancer in humans. Further studies by the same authors found that topical application of caffeine sodium benzoate and caffeine have both a sunscreen effect and enhance UVB-induced apoptosis and may be good agents for inhibiting the formation of sunlight-induced skin cancer.16

These studies present a potential use for caffeine in formulations used to decrease the risk of skin cancer formation after cutaneous damage from UV exposure. More studies need to be done to further examine caffeine's antioxidant potential. The above findings have prompted many manufacturers to add this popular agent to various cosmeceutical products on the market today (see Table 4).

Coffeeberry, harvested from the fruit of the coffee plant Coffea arabica, is considered to be one of the richest sources of antioxidants and is well known for its skin-rejuvenation properties. Coffeeberry contains potent polyphenols including chlorogenic acid, ferrulic acid, quinic acid, and condensed proanthocyanidins. The dermatologic application of CoffeeBerry® (J&J Technologies LC) extract was first recognized at the American Academy of Dermatology's Annual Meeting in February 2007. The first product to enter the market with CoffeeBerry as the basic ingredient is RevaléSkin (Stiefel Laboratories, Inc., Coral Gables, Florida) (see Table 5).

According to Stiefel Laboratories, Inc., CoffeeBerry has demonstrated high antioxidant properties, outperforming green tea extract and vitamins C and E. Proprietary research from the manufacturer has also shown that the use of the RevaléSkin CoffeeBerry skin care system consisting of 0.1% CoffeeBerry cleanser and 1% day and night creams showed statistically significant improvement in fine lines, wrinkles, pigmentation, and overall appearance when compared to vehicle. In addition to the evidence of safety and efficacy provided by the randomized, double-blind trials, further support comes from positive pathologic and in-vitro studies showing enhanced collagen production by fibroblasts. Studies are currently in progress to evaluate the use of the CoffeeBerry skin care system in conjunction with retinoids and intense pulsed-light treatments.17 More clinical studies need to be performed to fully assess the topical preparations containing CoffeeBerry extract, but polyphenols have already demonstrated efficacy in photoaging and skin cancer prevention.

The inclusion of botanical animal remedy additives in skin care products is becoming ever more popular. Potential antioxidant and anti-inflammatory benefits may prove beneficial for a number of conditions that dermatologists routinely treat, such as rosacea, photoaging, and skin cancer. The published effectiveness of prescription retinoids is well known, but equally well known is the irritation and redness often caused by the initiation of therapy. Botanicals may hold the promise of utility to reduce such inflammation. This is one of the best and most practical reasons to include botanicals in skin care protocols. Dermatologists should be aware of these products and be able to discuss their uses and potential benefits with their patients.

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Global Pruritus Therapeutics market report 2021 - product scope, industry outline, opportunities, risk and driving force

Global Pruritus Therapeutics market report 2021 – product scope, industry outline, opportunities, risk and driving force

The Global Pruritus Therapeutics Market report to look over the worldwide market scenario, industry development, just as the significant market participants.The Analysis incorporates market size, upstream circumstance, division, segmentation, price and cost and industry climate. Furthermore, the report diagrams the variables driving industry development and the depiction of market channels.The…