#Paracetamol IV Market Share

[spermarket]

Paracetamol IV Market Demand, Trends, Share, Revenue, Opportunities and Future Competition: SPER Market Research

Paracetamol IV (intravenous paracetamol) is a formulation of the well-known pain reliever and fever reducer paracetamol (often referred to as acetaminophen) designed for intravenous injection. It is mostly used in clinical settings to treat moderate to severe pain, particularly after surgery, and to lower fever in hospitalized patients. Because the intravenous version acts quickly, it is very beneficial for postoperative patients who require prompt and effective pain control. It is a safer alternative to opioids since it reduces the demand for medications to manage pain. 

According to SPER market research, ‘Global Paracetamol IV Market Size- By Indication, By Application, By End Use - Regional Outlook, Competitive Strategies and Segment Forecast to 2034’ state that the Global Paracetamol IV Market is predicted to reach 1150.18 million by 2034 with a CAGR of 3.72%. 

Drivers: 

The primary reasons for the growth of the intravenous paracetamol market are its use in pain management, particularly in post-operative care, and fever control. In particular, for those who are unable to take oral medications, intravenous paracetamol is a great therapy option that eliminates pain rapidly and efficiently. It is increasingly being used as part of a multimodal approach to pain management in combination with NSAIDs and opioids, in line with the increasing need for comprehensive pain relief choices. The growing demand for non-opioid alternatives, especially as the number of surgical procedures increases, benefits the industry. Intravenous paracetamol improves patient outcomes and speeds up recovery by precisely relieving pain and reducing opioid dependence. Countries. 

Restraints: 

The potential for side effects like hepatotoxicity and anaphylaxis is a major barrier in the global market for intravenous paracetamol, which makes doctors use it cautiously. Ongoing research is necessary to determine acceptable dosage guidelines and ensure long-term safety. Manufacturers must focus on post-marketing surveillance and healthcare professional training in order to boost trust in its use. 

Request a Free Sample Report: https://www.sperresearch.com/report-store/paracetamol-IV-market.aspx?sample=1 The strong need for pain management in surgical and hospital settings is driving the North American market for intravenous paracetamol. Growing surgical procedures, regulatory support, and sophisticated healthcare infrastructure all fuel market expansion. Its position is strengthened by strategic alliances and formulation advancements, with an increasing emphasis on non-opioid substitutes. 

Some significant market players are Abbott, Aurobindo Pharma, Bristol-Myers Squibb Company, Cipla Inc., Dr Reddy's Laboratories Ltd., Lupin, Mallinckrodt (Mallinckrodt Pharmaceuticals).

For More Information, refer to below link: –  

Paracetamol IV Market Growth

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[asrarblog]

Dear Colleagues!  This is Pharma Veterans Blog Post #282. Pharma Veterans shares the wealth of knowledge and wisdom of Veterans for the benefit of Community at large. Pharma Veterans Blog is published by Asrar Qureshi on WordPress, the top blog site. If you wish to share your stories, ideas and thoughts, please email to asrar@asrarqureshi.com for publishing your contributions here.

  For the public at large, the question of spurious or more popularly known ‘Ja’alee’ drugs keeps popping up in a very troubled way. Being a veteran of Pharma industry, I consider it appropriate to write on this subject and clarify about various aspects of the problem.

Some time back, I heard a statement on TV from Mr. Gillani, Head of Transparency International Pakistan. He said, “80% drugs in Pakistan are Ja’alee”. It is a rather irresponsible statement coming from a responsible person. There are no statistics to support this statement; it is just hearsay. More recently, WHO coordinator in Pakistan, Mr. Khalid Saeed echoed similar sentiment in a seminar. This is more serious because Mr. Khalid Saeed is an insider of the industry and the regulator. General public has also come to believe that most drugs available on the market are Ja’alee.

Let us first define what is Ja’alee.

Drug Regulatory Authority Pakistan (DRAP) is authorized to regulate and control the veterinary and human medicines, nutritional supplements, nutraceuticals, and medical devices. DRAP registers all these products, regulates the import and sale of active ingredients, controls the prices of human medicines only, and regulates the sales of manufactured and imported products. It is a handful. We shall also see later whether DRAP is adequately equipped to do this huge task in the manner that it is supposed to be done.

The governing law for medical business is Drug Act 1976. It was enforced in April 1976 by the then PPP government led by Z. A. Bhutto; the Health Minister was late Sheikh Rasheed. Prior to this, the PPP government had introduced Generic Policy. As per this policy, all medicines were to be labeled and prescribed by the generic name (the active ingredient name); no brands please. For example, Paracetamol would be sold as Paracetamol and not as Panadol or Calpol or other hundred such names. The intent of Generic policy was to counter the rise of brands through marketing activities, and to reduce the influence of marketers on prescribing physicians. Good intentions, however, need proper planning, resources, execution and monitoring. Generic policy was a non-starter from the being, but it did drag for about three years. Finally, the government abandoned it and introduced Drug Act 1976, which brought the Brands back. This is still the law, though several amendments and additions have been done to cater emerging needs.

Please visit https://www.ppma.org.pk/wp-content/uploads/2016/04/The-Drugs-Act-1976-3.pdf to read the full text of Drug Act 1976.

In the Chapter 1, among ‘Definitions’, the Act defines four problem categories. These are reproduced below.

(a) “Adulterated drugs” means a drug (i) which consists in whole or in part of any filthy, putrid or decomposed substance or which contains any foreign matter, vermin, worm, rodent or insect; or (ii) which has been manufactured, packed, or held under unsanitary conditions whereby it [has] been contaminated with dirt, filth or any other foreign matter or whereby it may have been rendered injurious to health; or (iii) the container of which releases any poisonous or deleterious substance which may render the contents injurious to health; or Page 2 of 32 (iv) which bears or contains as an ingredient a substance other than the prescribed substance; or (v) with which any substance has been mixed or packed so as to reduce its quality or strength or for which any substance has been substituted wholly or in part;

(f) “counterfeit drug” means a drug or the label or outer packing of which is an imitation of, or resembles or so nearly resembles as to be calculated to deceive the label or outer-packing of a drug of another manufacture;

(s) “Misbranded drug” means a drug (i) which is not labelled in the prescribed manner; or (ii) on the label or labelling of which any word, statement or other matter or information required by the rules to appear on the label or labelling is not prominently placed with such conspicuousness (as compared with other words, statements, designs, or devices on the label or labelling) and in such terms as may render it likely to be read ‘and understood by the ordinary individual under customary conditions of purchase and use; or (iii) which is not labelled with such directions for use and such warnings against use in indications where its use may be dangerous to health, or against unsafe dosage or duration of administration or application in such manner and form as are necessary for the protection of users or as may be prescribed; or (iv) the label or container of which, or anything accompanying which, bears any statement, design or device which makes any false claim for the drug or which is false or misleading in any particular; or (v) which is so coloured, coated, powdered or polished that damage is concealed, or which is made to appear of better or greater therapeutic value than it really is; or (vi) which is manufactured according to the specifications of a particular pharmacopoeia or any other document as may be prescribed and the label does not bear the name of that pharmacopoeia or document;

  (z-b) “Spurious drug” means a drug (i) which purports to be a drug but does not contain the active ingredient of that drug; or (ii) which purports to be the product of a manufacturer, place or country of whom or of which it is not truly a product; or (iii) which is imported or exported or sold or offered or exposed for sale under a particular name while actually it is another drug; or (iv) the label of which bears the name of an individual or company purporting to be its manufacturer or producer which individual or company is fictitious or does not exist;

When Ja’alee drugs are talked about, it is mostly a reference to 1, 2 & 4. #3 is also relevant but is more technical.

You can see that there are several ways in which a drug may be different from the one prescribed to you by your doctor. Medicine business is a serious business and must be taken very seriously.

In the next posts, we shall see the following topics to comprehend the problems and suggestion for solutions.

Licensing and Registration

Pakistan Pharma Market

Pharma Industry in Pakistan and Neighboring Countries

Pharma Marketing

Working of DRAP

Where it may go wrong

Thoughts on Solutions

Continued……

The Case of ‘Ja’alee’ (fake/ spurious) Drugs – The Basics – Blog Post #282 by Asrar Qureshi Dear Colleagues!  This is Pharma Veterans Blog Post #282. Pharma Veterans shares the wealth of knowledge and wisdom of Veterans for the benefit of Community at large.

[withabackpackandcamera]

November 8th, 2018

Day 6: The Forever Long Boat Tour of Inle Lake

After waking up this morning, dark and early, everyone gathered downstairs to wait for the tuk tuks to grab us and take us to the starting point of our boat tour. Unlike the sign-up list for yesterday’s tour, the sign-up today had about 15 people who were all present this morning for the trip, which ended up being pretty awesome. It was still pretty cold outside by the time we got on our tuk tuks and drove off. After a short drive through some in-streets to pick up our soon-to-be-breakfast, we made it to the location where we boarded our three long boats for the day.

Because it was still early, the sun was still a ways away from rising. As a result, the boat ride out toward the lake was pretty chilly. Luckily, we were supplied with blankets to keep warm under until the sun decided to rise. After boating out for a bit and looking around the lake as everything started to awaken, we made our first stop on the banks of a small floating garden for breakfast. Breakfast today was a meat samosa, savory sticky rice, a banana, with tea and water. The meal was nice, warm, and yummy for a cool morning.

After breakfast, we continued on our way. By this point, there was still no visible sun due to the thick clouds overlying the lake. As a result, we never actually got to see the sun rise over the lake. Bummer. So we just continued on our way underneath the thick layer of clouds until we reached our first stop for the day, a silversmith shop where we learned about the process of making silver things (like silver jewelry) before walking through their silver shop to make it to the exit. Things here were pretty expensive so I didn’t look around for too long before reaching the exit, where the others were waiting. There, I met the first of many fellow hostelers on the boat trip, Jake, an Englishman who quit his job in construction and has been traveling and finding jobs in between to support his current 21-month trip around the world. A really nice guy. Throughout the day, I also ended up meeting Jack and Asli, a couple from England who both quit their jobs to travel for a year, and Sebastian (Switzerland) and Stefano (Italy).

Once we were back on our boats, our next destination was the 5-Day Traveling Market. We had about 45 minutes to roam around the market and I ended up going around with Marion and Jake. Because I had already visited the Nyaung U market, I wasn’t crazy about this repeat market scene. However, one difference I picked up on was that there were a lot more Pa’O people here (the tribe with women who wear the brightly colored turbans), probably because they were from the area. Along our stroll, we made random turns and ended up outside a small school where kids were enjoying their recess time and playing volleyball outside. We stood there to watch for a little bit before turning back to our boat stop.

The next stop was Indein Pagoda. As we made our way over to the pagoda, the clouds finally started to lift, and the sun finally came out to warm up the lake around us. The boat ride was really nice and pleasant as we boated through the open lake before making a turn into the smaller, winding waterways to get to Indein Pagoda. At the pagoda village, we paid a small fee to bring our cameras in (an entrance fee of sorts) and walked down a long, covered walkway that slowly wound its way toward the pagoda in the back. Along the way, we glanced around as merchants began setting up shop for the day. Once we finally reached the pagoda, we explored the area, which was dotted with little stupas everywhere. It wasn’t long until we saw our share of stupas and made our way back down toward our docked boats. Because we were a bit early, I took the opportunity to peel off and look around the area at some small shops and take some photos of the locals, both at work and lounging around.

Back on the water, we boated our way out of the area and back into the open water, where we eventually made it to our next stop: lunch on a floating Inle Lake house. By this time, the sun was high in the sky and the temperatures were much warmer than earlier this morning, yet still extremely pleasant with the nice lake breeze. At the house, we were welcomed with some local tea leaf salad before being seated for our homemade lunch, which consisted of fried fish, rice, lettuce, tomatoes, cucumbers, salad, soup, and French fries. The table was loaded with food but by the end of lunch, we were all stuffed with most of the plates and bowls completed cleaned off. Whew, so delicious!

With our bellies full of yummy food, some of the local women at the house offered us a make-up session, where they would beautify us with thanakha, a yellowish-white cosmetic paste made from ground bark (ingredients include coumarin and marmesin) that is usually applied to the face for cosmetic beauty, sunburn protection, and smooth skin promotion. A lot of us, including me, volunteered to be beautified and it was fun!

After our thanakha was on, it was time for some canoe racing in the local lake waters! Because I was scared that I might actually fall into the water, I left my phone and camera behind at the house, and as a result, didn’t document anything, which was too bad because we ended up making it back to the house unscathed, though a little wet. Marion and I were in a canoe together with veteran leadership from one of the local women at the house. At first, it was really fun to just glide through the calm, warm waters of the lake. However, as we made it out further from the house, we got more and more tired. Eventually, we were passed by all the other canoes (it wasn’t actually fair since there were more people rowing in the other canoes compared to our two-person canoe). But it was a lot of fun to give it a try despite realizing that canoeing was actually pretty difficult and required a lot of arm movements I wasn’t used to.

Once back at the house, we all lazed around the living room for a bit before making our next move, which was stopping at a local lotus weaving shop. There, we learned about how lotus weaving works and how they make fabric and clothing out of the lotus threads they make from the stems of the lotus flowers. It was really cool to see the workers make fabrics out of the lotus threads with the antiquated technology they were using, which included a complicated wooden contraption with strings and pedals everywhere. Pretty cool! We looked around for a bit and glanced in at the shop next door prior to re-boarding our boats.

Next was the cigar making stop. We stopped here to learn about the cigar making process in Inle Lake and watched as one of the women made a ton of cigars. I’m not sure how many cigar she made while we were sitting there watching her but after a while, people got to try some cigars before we left for our last stop of the day: Maing Thouk Bridge, the same bridge I stopped by yesterday during my bike ride.

Because it was going to be a quick stop, I wasn’t actually sure what I would do at the stop since I saw most of the surrounding areas yesterday. But, luckily, as I was walking around, I noticed a little sign/logo that looked like it represented a clinic for mothers/babies, maybe a local birthing clinic. I decided to pay a visit after lingering outside for a few minutes, debating whether I actually wanted to stop by or not. Once I was inside, I saw an older woman who looked like a nurse given the little hat she was wearing looked like the old-school hat nurses usually wore as part of their uniforms back in the day. She didn’t know much English but she was nice enough to try and converse with me after I introduced myself and told her I was a doctor from the U.S. and showed her a couple of photos from work. She was really intrigued and looked very happy to have me stop by. After I shared some of my photos, she shared with me a little book of patient records where she had recorded a bunch of things. Upon closer examination, I realized, based on the records that I saw, that this was actually an urgent care clinic rather than an obstetrics/midwives clinic. Intrigued that I had stumbled upon this, I got permission to flip through the records a little. Fever, vomiting, and diarrhea were some of the diagnoses I saw. And based on the records, the primary things that could be done at this clinic included giving patients paracetamol (acetaminophen), oral antibiotics (like cephalexin), and even giving patients infusions of normal saline IV fluids. Pretty neat! After looking through the booklet, I shared with the nurse some of the different types of medications I brought along with me in case I needed it on the trip and she seemed entertained by that as well. What a fun local experience!

After spending ten or so minutes at the clinic, I bid the nurse farewell and walked back to the dock, where we boarded our long boats and made our way back toward the starting location. Along the way, we made a quick stop to take photos of fake fishermen posing with their old-school baskets. Because the lighting wasn’t great and the photo op itself wasn’t unique, I didn’t make a huge effort to get the photo I had envisioned in my head before the trip. Plus, the guy we were parked next to wasn’t as classic-looking as the other guy the other boats stopped next to to photograph. Oh well. Maybe next time.

Shortly after finishing our boat trip (at this point, it was about sunset time), we made it back to our hostel where we enjoyed some crepes as our welcome-back-snack before all moving upstairs for some drinks at the hostel bar’s happy hour. We were a little bit late for sunset but ended up enjoying our time upstairs as the evening approached. We hung out for a bit before all deciding that we would go to the balloon fireworks festival instead of dinner at an Indian restaurant nearby.

As a group with one of the hostel workers, Amy, as the lead, we walked over to the night market grounds (where Marion, Christian, and I were yesterday) for some food before heading over to the balloon festival (which we later realized was actually here as well). It wasn’t long after we arrived there that we started to lose people left and right. By the time moves were made, the only ones left who were interested in dinner at a festival stall were Jack, Asli, Jake, and me. We wandered around for a little and eventually found a nice little food tent where I ordered a shan noodle soup dish with veggies. It was simple but pretty good, despite the fact that it was lacking meat. As we finished eating, we saw what we came to see: a big balloon lined with lights released into the sky. Though it was only one balloon released (with no dangerous fireworks firing down at us), it was still cool to see (even though we weren’t at the site where the balloon was actually launched unfortunately). And just when we thought it was all over, the festival fired about 3-4 rounds of spectacular fireworks into the sky above us! It was crazy and way more extravagant than most fireworks shows I’ve seen recently!

Once the fireworks show had fizzled out, we roamed around, played some carnival games (a can toss game, a darts game) with a little bit of winning, before walking to the other side of the fairgrounds where Jake had spotted an interesting game where two people sat on a horizontal bamboo pole and tried to knock each other off the pole with bags filled with sawdust and wood shavings/mulch. At first, we just watched from the sideline with lots of intrigue. But eventually, we came up with the idea of putting two foreigners on the bamboo poles to battle each other. Once that idea was put into play, you should have seen how big the crowd got around the area! A quiet little venue suddenly became the hottest spot on the fairgrounds! And what followed was hilarious!!!! Jack and Jake were the first competitors with Jake winning the first foreigner match-up. Epic! And what was one match ended up becoming a huge tournament-like spectacle as Jake continued to win, one after another, with tons of people stepping up to the plate to challenge him. After about ten undefeated rounds, he finally fell to a local hahaha. You should have seen the craze and energy in the atmosphere when this was all going down! What an experience to be able to enjoy with the locals! After Jake had lost his crown, several more hostelers went up to give it a try, leading to more laughter and more fun. Part of me also wanted to go up, but I definitely didn’t think it was a good idea to go up against these huge guys, hahaha. But I really wished I had a chance! Poo.

After watching the bamboo gladiator game for a while, a lot of us moved over to the slippery bamboo pole climb right next door. Essentially, the goal of this game was to climb to the top of a 3-4 story tall bamboo pole that was greased from top to bottom. What ensued was entertaining, as people tried to climb as high as possible using any strategy they could think of, from climbing solo to climbing while building up a tower of people to support the highest climber (of course this involved Jake and Ben, one of the Aussies I later met). The contestants got pretty high up but, as you can imagine, it was impossible to get to the top without having the skills of those Spanish tower climbers that you always see. But it was fun to see everyone try!  

Before long, it was already 10:30pm and the festival was starting to wind down. We collected everyone and slowly made our way back to the hostel for some much needed showers and rest. What a fun, jam-packed, entertaining day full of surprises! Once in bed, I thought to myself how lucky I was to meet so many cool people on the boat tour today and how it totally made my day!

And as for tomorrow morning… back to Yangon!

5 Things I Learned Today:

1. Lotus fabric is more expensive than silk fabric because it takes more time to make and is more labor-intensive and because lotus flowers only grow during certain seasons, making it more limited. Supposedly, to make a 2 meter lotus scarf, you need approximately 4000 lotus flower stems. Usually, to make one lotus fiber/thread, you break four lotus stems, pull the the string-y thing on the inside out from the stems and twine and roll them together with 3 other stems-worth of string-y things to get a piece of thread.

2. To color the lotus fibers/products, you can use materials from different plants. For example, using the bark from a mango tree will give you a red color. Tamarind usually gives you yellow, while lotus usually gives you green.  

3. Small clinics near Inle Lake are mostly visited for minor illnesses. The clinic staff mostly see local patients and serve as an urgent care for those patients. In the particular clinic that I stopped by, they usually see around 25 local patients daily. The medications that are most prescribed: Tylenol and antibiotics. The most common complaints: fever, diarrhea, and vomiting. And what happens when foreigners needs medical attention? They’re referred directly to the closest hospital for care.

4. Cigar making in the Inle Lake region usually involves banana leaves (that serve as the outside shell of the cigar), tobacco, newspaper (that serves as the burning part?), and sticky rice (as the glue to keep it all together). It can take about 35.2 seconds to make one cigar (that was the time it took for our lady to make one. I timed it haha).   

5. Everything happens in Inle Lake. You bathe in the lake. You wash clothing in the lake. You wash dishes in the lake. You probably poo and pee in the lake too. Hmmm. Somehow, I feel like nothing gets cleaned in the lake because of all of that… It would kinda stink to be downstream of everyone else…. Stink? Get it?! Hahaha.