#Nublexa Tablet
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Nublexa Tablet - Regorafenib (40mg) - Bayer Zydus - Pilcare - Exporter from India to Guyana
Nublexa Tablet is a Tyrosine kinase inhibitors used in the treatment of cancer of colon and rectum.
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Regorafenib Stivarga Package insert and Lowest cost
Regorafenib is used to treat colon and rectal cancer (cancer that begins in the large intestine or the rectum) that has spread to other parts of the body in people who have not been treated successfully with certain other medications. It is also used to treat gastrointestinal stromal tumors (GIST; a type of tumor that grows in the stomach, intestine [bowel], or esophagus [tube that connects the throat with the stomach]) in people who were not treated successfully with certain other medications.
How should this medicine be used?
Regorafenib comes as a tablet to take by mouth. It is usually taken with a low-fat meal (containing under 600 calories and less than 30% of calories from fat) once a day for 3 weeks and then skipped for 1 week. This treatment period is called a cycle, and the cycle may be repeated for as long as your doctor recommends. Take regorafenib at the same time every day.
What special precautions should I follow?
Before taking regorafenib, tell your doctor and pharmacist if you are allergic to regorafenib, any other medications, or any of the ingredients in regorafenib tablets. Ask your pharmacist for a list of the ingredients.
What should I do if I forget a dose?
If you miss a dose of regorafenib, take the missed dose as soon as you remember it on that day. Do not take two doses on the same day to make up for a missed one.
What side effects can this medication cause?
Regorafenib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: tiredness weakness loss of appetite diarrhea swelling, pain, and redness of the lining of your mouth or throat weight loss hoarseness or other change in the sound of your voice.
Above content source: https://www.911globalmeds.com/info/208-1-Regorafenib-Stivarga-Resihance-Nublexa-Medication-Patient-Information-In-English.pdf
The guaranteed Lowest Cost of STIVARGA / Regorafenib 40 mg @ $15.50 and $102.65 per tablet Online.
Above Price source: https://www.genuinedrugs123.com/132-Anti-Cancer-Drugs-Generic-Regorafenib-Brand-Stivarga.aspx
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Nublexa 40mg tablet - Apple pharmaceutical
Nublexa 40mg is an antineoplastic drug that prohibits Nublexa 40mg tablet price the growth and spread of cancer cells in the body.
Nublexa 40mg tab is needed to treat colorectal cancer and liver cancer. Nublexa 40 mg tablet It is also needed to treat a rare type of tumor that can affect the esophagus, stomach, or intestines.
Nublexa 40mg tablet is commonly Nublexa 40 mg tablet given after other cancer regimens have been tried without success.
Nublexa 40mg is a prescription drug that is used under the supervision of medical practitioners.
INDICATION :
Nublexa 40mg tablet is indicated for the treatment of metastatic colorectal cancer (CRC) who have been Nublexa 40mg previously treated with or are not considered candidates for, available therapies. These include fluoropyrimidine-based chemotherapy, an anti-VEGF therapy, and an anti-EGFR therapy (see section 5.1)
Nublexa 40mg tablet tumors (GIST) who progressed on or are intolerant to prior treatment with imatinib and sunitinib
Nublexa 40mg tablet price is indicated for the treatment of hepatocellular carcinoma (HCC) who have been previously treated with sorafenib.
DOSAGE: Colorectal cancer :
The Nublexa 40mg usual dose is 160mg (four 40mg tablets) Po q Day for the first 21 days of each 28-day cycle.
Gastrointestinal stromal tumor :
The usual dose is 160mg Nublexa 40mg (four 40mg tablets) Po q Day for the first 21 days of each 28-day cycle.
Hepatocellular carcinoma :
The usual dose is 160mg (four 40mg tablets) Nublexa 40mg Po q Day for the first 21 days of each 28-day cycle.
Follow the treatment of these conditions until disease progression or undesirable toxicity.Nublexa 40mg
MECHANISM :
Regorafenib belongs to oral Nublexa 40mg tumor deactivation agent which potently stops multiple protein kinases, contain kinases included in tumour angiogenesis (VEGFR1, -2, -3, TIE2), oncogenesis Nublexa 40mg (KIT, RET, RAF-1, BRAF, BRAFV600E), metastasis (VEGFR3, PDGFR, FGFR) and tumour immunity (CSF1R). Regorafenib prohibits mutated KIT, a major oncogenic driver in gastrointestinal stromal tumors, and thereby stops tumor cell multiplication. In preclinical studies, regorafenib has described potent anticancer activity in a broad spectrum of tumor models containing colorectal, gastrointestinal stromal and hepatocellular tumor models which are likely mediated by its anti-angiogenic and anti-proliferative effects. In addition, regorafenib decreased the levels of tumor analog macrophages and has shown anti-metastatic effects in vivo. Major human metabolites (M-2 and M-5) displayed similar efficacies, compared to regorafenib in vitro and in vivo models.
DRUG INTERACTION
Nublexa 40mg concomitant use with strong CYP3A4 inducers will decrease Regorafenib plasma concentrations and increased plasma concentration of active metabolite M-2; M-5.
Nublexa 40mg interaction with strong CYP3A4 inhibitor will increase Regorafenib plasma concentration and reduced the plasma concentration of active metabolite M-2; M-5.
Nublexa 40mg interaction with BCRP substrate will increase the plasma concentration of the BCRP substrate.
MISSED DOSE
If a dose is missed, patients must consult with a medical practitioner and follow the instructions given by them. Thereby missed dose should be avoided and follow the regular dosing schedule
STORAGE
Store the Nublexa 40mg at 25℃ (77℃)
Keep the drug in its original container bottle
Keep the bottle tightly closed after one time used.
SIDE EFFECTS :
Common side effects occurring in greater than 30 %: Nublexa 40 mg tablet
Hand-foot syndrome , Diarrhea, Low platelets, Mouth sores/inflammation, Weight loss, Infection, Nublexa 40 mg tablet Anemia, Increased liver enzymes (AST, ALT), Fatigue, High blood Nublexa 40mg pressure, Voice disorder (Dysphonia), Protein in the urine, Low calcium, Nublexa 40 mg tablet Low phosphorous, Low white blood cells, Decreased appetite, Increased lipase & amylase, High bilirubin in the blood, Low sodium, Nausea. Nublexa 40mg
Less common side effects occurring in about 10-29% of patients receiving Nublexa 40mg :
Pain, Fever, Rash, Low potassium, Decreased blood clotting, Increased bleeding, Headache, Alopecia. Nublexa 40 mg tablet.
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Email : [email protected]
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Website: applepharmaceuticals
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