#Mycobacteriumtuberculosis

[thxnews]

VDEC Assay Combats Antimicrobial Resistance

A groundbreaking development in the fight against tuberculosis has emerged from the Vaccine Development and Evaluation Centre (VDEC). The centre has created a standardized assay designed to reduce antimicrobial resistance and improve treatment outcomes for tuberculosis patients. This innovative tool will transform tuberculosis treatment protocols by screening compound libraries for effectiveness against Mycobacterium tuberculosis in combination with the chemotherapy drug Pyrazinamide (PZA).  

Scientists working in a Class III secure microbiological safety cabinet. Photo by VDEC. Gov.uk.  

The Significance of the VDEC Assay

Antimicrobial resistance (AMR) poses a significant threat to global health, particularly in the treatment of tuberculosis (TB). Each year, TB claims the lives of 1.6 million people worldwide, with drug-resistant strains making treatment increasingly challenging. The World Health Organization has set a goal to end tuberculosis by 2035, underscoring the urgent need for novel therapies that shorten treatment duration and target AMR strains effectively.  

Objectives and Methodology

The primary aim of the VDEC assay is to enhance the efficacy of Pyrazinamide, a key component of front-line TB chemotherapy. Pyrazinamide plays a crucial role in the six-month treatment course for TB, and boosting its activity could reduce the emergence of drug-resistant strains. This would not only shorten treatment times but also minimize the toxic effects associated with prolonged drug use. Table 1: Key Objectives of the VDEC Assay Objective Description Boost Pyrazinamide Activity Enhance the drug's efficacy to combat TB more effectively Reduce Drug Resistance Lower the incidence of drug-resistant TB strains Shorten Treatment Duration Decrease the length of TB treatment protocols Minimize Toxic Effects Reduce the side effects of prolonged drug use   Addressing the Challenge of Standardization Historically, in vitro assessments for Pyrazinamide have been limited due to a lack of standardized testing conditions. This gap has hindered the development of effective tools to assess and enhance PZA activity. VDEC has tackled this issue by defining the conditions for PZA assessment in fermenter models that replicate the acidic environments where PZA is active. This breakthrough has led to the development of a standardized assay that can screen for active molecules and further characterize their efficacy.   Collaborative Efforts and Screening Processes VDEC’s innovative approach involves collaboration with industrial partners to screen large compound libraries—each containing over 80,000 compounds—to identify molecules that enhance PZA's efficacy. This method is also being applied to other AMR pathogens, including Pseudomonas aeruginosa, Neisseria gonorrhoeae, and Mycobacterium abscessus, as well as viral threats like coronaviruses.  

Visual Guide to what VDEC does. Artwork by VDEC. Gov.uk  

VDEC's Unique Capabilities

The VDEC team at the UK Health Security Agency (UKHSA) in Porton Down leverages a unique combination of fermentation, molecular methods, and bespoke high-throughput screening (HTS) assays for drug discovery and evaluation in pathogenic bacteria. Their expertise and innovative techniques are critical in the fight against AMR.   Achievements and Future Work The VDEC team has already discovered several "hits" that potentiate PZA and are currently characterizing these molecules to understand their mode of action against M. tuberculosis. The success of this assay method has been recognized with its acceptance for publication in prestigious scientific journals.   Industry and Government Support Support for VDEC’s work comes from various quarters. The UK government’s commitment to combating AMR and improving public health is reflected in initiatives like this. Collaboration with academia, public sectors, and industry worldwide underscores the importance of a unified approach to tackling TB and AMR.  

In Conclusion

Moreover, the VDEC standardized assay represents a significant advancement in the battle against tuberculosis and antimicrobial resistance. By enhancing the efficacy of Pyrazinamide and reducing drug resistance, this innovative tool has the potential to revolutionize TB treatment and improve patient outcomes. As the VDEC team continues to develop and refine their assay, the future looks promising for more effective and efficient tuberculosis therapies. Further reading is available on the WHO website.   Sources: THX News & UK Health Security Agency. Read the full article

[nilemsmusic]

DIA DE LA TUBERCULOSIS 🫁 #tuberculosis #MycobacteriumTuberculosis #diamundialdelatuberculosis #worldtbday #worldtuberculosisday https://www.instagram.com/p/CM0BhvYFqzM/?igshid=r7z0049i5neb

[microscopiaiwm]

❇️ Follow @microscopia.iwm ✅ Notes on tuberculosis available on our website (link in bio) ✔️ Tuberculosis (TB) is a contagious infection that usually attacks your lungs. It can also spread to other parts of your body, like your brain and spine. A type of bacteria called Mycobacterium tuberculosis causes it. Follow @microscopia.iwm @microscopia.iwm @microscopia.iwm Tag and Follow #microscopiaiwm #microbiota #microbiologist #microbiologymagazine #microbiologylove #microbiology #biotechnology #biotechnologyguy #biotechnologystudents #biotechnologist #biology #biotechnologylab #bio #biologymemes #tuberculosis #disease #medicalmicrobiology #tb #mycobacteriumtuberculosis #bacteria (at USA) https://www.instagram.com/p/CG_kTbAHPbv/?igshid=1x3p9l7vm2nqf

[cooljyotialfaa]

Check how Alfaa’s UV Air Purification is Effective in Preventing Tuberculosis and Other Respiratory Issues https://www.alfaauv.com/blog/are-uv-air-purifiers-effective-in-preventing-tuberculosis-and-other-respiratory-issues/

[althealoves18]

"TB or not TB?" that is the question. #microbiology #Mycobacteriumtuberculosis

[net-bolezniamru]

Все мы наслышаны о туберкулёзе... Благодаря антибиотикам и прививкам, это заболевание уже давно не кажется таким страшным. Но вот наши предки очень сильно боялись данного заболевания, ведь туберкулёз был причиной смерти в 25 % случаях.

В наши дни, этой болезнью страдают 10 миллионов населения Земного Шара, а 75 % из них живут в развивающихся странах. В развитых странах, рецидив туберкулёза среди населения стал возможным из-за другого страшного заболевания - СПИДа.

Туберкулёз - инфекционное заболевание, причиной которого является палочка Коха. Эта бактерия может передаться очень легко от пациента к другому пациенту воздушно-капельным путём. Даже если бактерия проникла в организм человека, развитие тяжелой формы туберкулёза происходит только при определенных условиях.

Для туберкулёза - характерны многие симптомы:

кашель;

жар;

потеря аппетита;

легкая астения;

расстройства пищеварения;

сыпь красного цвета на ногах;

повышенный пот ночью;

усталость;

потеря веса;

затрудненное дыхание при физических нагрузках;

кровохарканье;

туберкулёзная бронхопневмония.

Для диагностики туберкулёза могут использоваться:

рентгенография груди;

тесты на туберкулин;

прямой осмотр под микроскопом (неточный анализ).

Лечение туберкулёза проводится при помощи антибиотиков (одновременно 3 или 4 антибиотики) на протяжении 6 месяцев.

Важно держать пациента в первые 3 недели лечения под карантин. После этого, больной больше не представляет риск заражения для здоровых людей.

Профилактика туберкулёза состоит в вакцинации БЦЖ.

[ahecworld]

Support Jagriti Recover From Tuberculosis My name is Jagriti Batra and I am 27 years old. I am here to raise funds for myself. I am working as a private employee. I live in New Delhi, Delhi with my parents. I've been suffering from Tuberculosis for the past few months. I am receiving medication and treatment in a private hospital and it will still go on for a long time. Until now, I've spent about Rs. 40,00,000. I've arranged the amount from savings, loans & selling assets. In the next few days, I need Rs.15,00,000 more for further treatment as tuber... Read more - http://m-lp.co/jagritib?utm_medium=whatsapp_status&utm_source=app To donate - https://milaap.org/fundraisers/support-jagriti-batra/deeplink?deeplink_type=upi&utm_medium=whatsapp_status&utm_source=app #A2g #ahecounselling #ahec #tuberculosis #tuberculosisawareness #mycobacteriumtuberculosis #worldtbday #healthcare #worldtuberculosisday #endtb #donations #fundraiser #hope #helpingothers #nonprofitorganization #volunteering #india #coronavirus #savealife #kindness #socialwork #rescue #charity #donate #community #communitysupport #giveback #helpingothers

[happilyhealthcollector-blog]

AED

AEDというのは医療資格を保持しない普通の人でも扱える医療機器で、機器本体から流れる音声ガイダンスの通りにおこなうことで、心臓が細かく震える心室細動の治療の効力を実現します。

結核菌（Mycobacteriumtuberculosis)は、菌に感染した人がゴホゴホと「咳」をすることによって室内に散布され、空中でフワフワ漂っているのを別の人が呼吸の際に吸い込むことによってどんどん感染します。

折り目正しい日常生活の継続、食べ過ぎないこと、適度な軽い運動やスポーツなど、一見アナログともいえる自分の身体への意識が老化防止に��活用されるということです。

アイコンタクトで、当事者がセラピーアニマルをとても愛おしく思うと「優しさのホルモン」とも呼ばれるオキトキシンが分泌されて、ストレスを軽減したりヒーリングなどに結びつくのです。

耳の内部構造は、大まかに「外耳」「中耳」「内耳」の３か所に区別されますが、中耳の部分に様々な細菌やウィルスなどがうつり、炎症になったり、液体が滞留する症状を中耳炎と称しています。

[guzguzcisn]

En busca de tus bacilos ♧ #mycobacteriumtuberculosis 👾🔬💉😷