#Michael (LGG)

[storieslikeclockwork]

Hug

CONTENT WARNING: Graphic Descriptions of Violence!, Mention of kn1ves!

Just a snippet from a sci-fi AU!

——

“LET GO!”

Michael had once again gained access to the knives, and rather than the usual disarming by Pione, Michael found himself effectively trapped in a hug.

Pione didn’t respond, ignoring the threats spilling out of Michael’s mouth as he kept his arms pinned at his sides. The young man tried to worm his way out, but when that didn’t work he resorted back to scare tactics.

“I’ll kill you! I’ll gut you like a fish and hang your intensities outside of your bedroom. I’ll gouge your eyes out and push you out of a skyscraper window. I’ll-“

Michael suddenly found his face pressed into Pione’s chest, cutting off the rest of the creative threats bubbling in his brain. Despite how restrictive the hold was, Pione’s actions didn’t seem aggressive. He was stern, but gentle.

“My grandpa used to do this for me when I was scared. I don’t know why, but it always made me feel better, being so close to him.”

Michael knew what he was talking about. Though he had only gotten this treatment once, he never forgot how secure he had felt, despite the craziness of everything around him. Back when he had seen Silas as a friend.

As the two sat in silence, the muffled curses coming from Michael’s mouth eventually died down, and Pione felt the slight tremors running through his body as he broke down. He didn’t say anything.

[cancersfakianakis1]

Patterns of failure among low-grade glioma patients treated with proton radiotherapy

Publication date: Available online 18 February 2019

Source: Practical Radiation Oncology

Author(s): Sophia C. Kamran, Michael Dworkin, Andrzej Niemierko, Marc Bussiere, Kevin S. Oh, Jay S. Loeffler, Helen A. Shih

Abstract

Purpose

Proton treatment may be a useful radiation therapy (RT) modality for long-term surviving glioma patients to reduce normal tissue toxicities. Photon studies demonstrate that most low-grade glioma (LGG) failures occur within the radiation field, supporting the use of more conformal treatment plans, yet it is unclear whether this can be translated to proton RT (PRT). Our objective is to examine our institutional experience to determine patterns of failure in LGG patients with respect to the irradiated volume with PRT.

Methods and Materials

Patients with WHO 2007 grade I-II or IDH1-positive mutation grade III LGG treated with PRT between 2005-2015 were retrospectively reviewed. Patients with documented local recurrences on MRI after receipt of PRT underwent comparison with initial treatment plan dosimetry to evaluate patterns of failure. A total of 141 patients were included in the final cohort.

Results

Median follow-up time was 46.7 months (range: 2.8-144) and five-year overall survival (OS) was 84%. Median PRT dose delivered was 54 Gy (RBE) (range, 45-60). There were 42 failures after PRT (30%). Median time to progression after treatment was 32.7 months (range, 4.8-93.6). Thirty-one patients (74%) failed in-field (defined as within the 95% isodose volume), five (12%) failed out-of-field, and five (12%) patients had marginal failures (defined as within 50-95% isodose volume). Five-year freedom from progression after PRT was 60.1% (95% CI 48.7-70.0). Five-year cumulative incidence of OS among those with recurrence after PRT was 33% and 96% among those without recurrence after PRT, p<0.001.

Conclusion

Of the LGG patients who had documented failures after PRT, most recurred within the radiation field, with few marginal failures, indicating that even with proton radiation, which can often have steeper dose gradients, coverage is adequate. Survival was poor for patients whose tumors recurred.

http://bit.ly/2SHqzhG

[mahalamagins]

LGG // NOV 10 — 29 GOAT SHOW: A celebration of the diversity of Byron Shire artists and community that Lone Goat Gallery is proud to be a part of. In the past 12 months, Lone Goat has produced 22 exhibitions featuring 125 artists and over 20 artist talks, workshops and performances and partnered with organisations such as the Byron School of Art, Byron Writers Festival, Byron Surf Festival, Trailer Projects and Red inc; Awesome! — Pictured Artist: Michael Cusack @cusack2 | CANTOS | Oil on Board | H 46 X W 38 CM | 2017 — GOAT SHOW will come to a close tomorrow Nov 29 at 4PM | 28 Lawson Street, Byron Bay; Get there! @lonegoatgallery

[swissforextrading]

The NCCR Digital Fabrication at ACADIA ’17

Pictured: Full-scale construction prototype of the NEST HiLo shell roof. The ultra-thin concrete roof was built with a cable-net and fabric formwork system and is on average 5 cm thick. Image credits: Block Research Group, Michael Lyrenmann --- The NCCR (Swiss National Centre of Competence in Research) Digital Fabrication will be leading a workshop at ACADIA 2017, this year hosted at MIT School of Architectural Planning. The NCCR Digital Fabrication is Switzerland’s initiative to lead the development and integration of digital technologies within the field of architecture. It was initiated in 2014 at ETH Zurich. Further partner institutions are the EPFL, Empa and the Berne University of Applied Sciences. The workshop, taking place at Autodesk, is called Computational Research in Architecture and Structures. The Block Research Group (BRG) from ETH Zurich, part of the NCCR Digital Fabrication, will run it. Participants will learn how to address advanced research questions in architecture, structures, and digital fabrication through computation, particularly through the use of compas, an open source, Python-based framework for “computational research in architecture and structures.” The ACADIA conference provides a platform to investigate the shifting landscape of architecture today, and to help navigate the future. This year it’s on the theme of Disciplines & Disruption, initiating a dialog about the state of architecture (as a discipline) and the impact of technology in shaping or disrupting design, methods, and cultural fronts. MORE ABOUT NCCR DIGITAL FABRICATION Initiated in 2014, the NCCR Digital Fabrication aims to revolutionize architecture through the seamless combination of digital technologies and physical building processes. More than 60 researchers from the disciplines of architecture, structural design, materials science, computer science, control systems engineering, and robotics collaborate to develop ground-breaking technologies for tomorrow’s construction. Their research allows Switzerland to take a leading position within the global field of digital fabrication. Initiated at ETH Zurich, the NCCR Digital Fabrication is partnered with EPF Lausanne, Empa and the Berne University of Applied Sciences. NCCRs are cross-disciplinary research networks funded by the Swiss National Science Foundation (SNSF). They support research in areas of strategic importance for the future of Swiss science, economy and society. NCCR investigators: * Prof. Philippe Block, Block Research Group, ETH Zurich (Director) * Prof. Robert Flatt, Physical Chemistry of Building Materials Group, ETH Zurich (Deputy Director) * Prof. Benjamin Dillenburger, Digital Building Technologies Group, ETH Zurich * Prof. Fabio Gramazio, Gramazio Kohler Research, ETH Zurich * Prof. Matthias Kohler, Gramazio Kohler Research, ETH Zurich * Prof. Guillaume Habert, Chair of Sustainable Construction, ETH Zurich * Prof. Marco Hutter, Robotic Systems Lab, ETH Zurich * Prof. Mark Paly, Computer Graphics and Geometry Laboratory (LGG), EPF Lausanne * Prof. Roland Siegwart, Autonomous Systems Lab (ASL), ETH Zurich * Prof. Roy Smith, Automatic Control Laboratory (iFA), ETH Zurich * Prof. Olga Sorkine-Hornung, Interactive Geometry Lab (igl), ETH Zurich * Prof. Yves Weinand, Laboratory for Timber Constructions (IBOIS), EPF Lausanne * Prof. Christophe Girot, Chair of Landscape Architecture, ETH Zurich * Prof. Walter Kaufmann, Chair of Structural Engineering, ETH Zurich * Prof. Joseph Schwartz, Chair of Structural Design, ETH Zurich * Prof. Jan Vermant, Laboratory of Soft Materials, ETH Zurich * Prof. Melanie Zeilinger, Institute for Dynamic Systems and Control, ETH Zurich Major current research projects: * DFAB HOUSE: Building with robots and 3D printers * HiLo roof prototype: Construction prototype for ultra-thin concrete roof * Vidy Theatre Lausanne: A pavilion built on a foundation of innovative research Future conferences hosted by the NCCR Digital Fabrication, and other opportunities: * ROB|ARCH 2018: Radical Cross-Disciplinarity * Digital Concrete 2018 * Master of Advanced Studies ETH in Architecture and Digital Fabrication at the NCCR Digital Fabrication --- MORE ABOUT ACADIA 2017 ACADIA was formed for the purpose of facilitating communication and critical thinking regarding the use of computers in architecture, planning and building science. The organization is committed to the research and development of computational methods that enhance design creativity, rather than simply production, and that aim at contributing to the construction of humane physical environments. A particular focus is education and the software, hardware and pedagogy involved in education. In 2017, the ACADIA conference ( is hosted by the MIT School of Architecture and Planning. The Conference Chairs are Takehiko Nagakura, Director of the Design Computation Group at MIT, and Skylar Tibbits, Co-Director and Founder of the MIT Self-Assembly Lab. Under the theme “Disciplines & Disruption” the organisers aim at initiating a dialog about the state of the discipline of architecture and the impact of technology in shaping or disrupting design, methods and cultural fronts. --- http://www.swissnexboston.org/the-nccr-digital-fabrication-at-acadia-17/ (Source of the original content)

[storieslikeclockwork]

Just a general story based board!

[cancersfakianakis1]

Risk Factors for Malignant Transformation of Low Grade Glioma

Publication date: Available online 21 December 2017 Source:International Journal of Radiation Oncology*Biology*Physics Author(s): Erin S. Murphy, Charles M. Leyrer, Michael Parsons, John H. Suh, Samuel T. Chao, Jennifer S. Yu, Rupesh Kotecha, Xuefei Jia, David M. Peereboom, Richard A. Prayson, Glen HJ. Stevens, Gene H. Barnett, Michael A. Vogelbaum, Manmeet S. Ahluwalia BackgroundThe incidence, risk factors, and outcomes of LGG patients who undergo malignant transformation (MT) in the era of temozolomide (TMZ) are not well known. This study evaluates these factors from a large group of WHO Grade II glioma patients treated at a tertiary care institution.MethodsPatient, tumor, and treatment factors were analyzed from an IRB-approved LGG database. Characteristics were compared using Chi-square and Wilcoxon signed-rank tests. Time-to-event was summarized using proportional hazards models. Univariate and multivariate survival analyses were performed.ResultsFrom a total of 599 patients, 124 underwent MT; 76 (61.3%) were biopsy-proven. MT incidence was 21% and median time to MT 56.4 months. The 5 and 10-year PFS for MT patients was 30.6% ± 4.2% and 4.8 % ± 1.9%, and for non-MT patients was 60% ± 2.4% and 38% ± 2.7%, respectively. The 5 and 10-year OS for MT was 75% ± 4.0% and 46 % ± 5.0% and non-MT patients was 87% ± 1.7% and 78% ± 2.3%, respectively. On MVA, older age (p=0.001), male sex (p=0.004), multiple tumor locations (p=0.004), chemotherapy alone (p=0.012), and extent of resection (p=0.045) remained significant predictors of MT.ConclusionsMT impacts survival. Risk factors include older age, male sex, multiple tumor locations, use of chemotherapy alone, and presence of residual disease. Our findings that initial interventions could impact the rate of MT are provocative, but this data should be validated using data from prospective trials. In addition to improving survival, future therapeutic efforts should focus on preventing MT.

Teaser

The incidence, risk factors, and outcomes of LGG patients who undergo malignant transformation in the era of temozolomide are not well known. This study evaluates these factors from a large group of WHO Grade II glioma patients treated at our tertiary care institution. We found that older age, male sex, multiple tumor locations, chemotherapy alone, and extent of resection were significant predictors of malignant transformation. http://ift.tt/2BBSQxO