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Patients With Long-COVID Show Abnormal Lung Perfusion Despite Normal CT Scans - Published Sept 12, 2024
VIENNA — Some patients who had mild COVID-19 infection during the first wave of the pandemic and continued to experience postinfection symptoms for at least 12 months after infection present abnormal perfusion despite showing normal CT scans. Researchers at the European Respiratory Society (ERS) 2024 International Congress called for more research to be done in this space to understand the underlying mechanism of the abnormalities observed and to find possible treatment options for this cohort of patients.
Laura Price, MD, PhD, a consultant respiratory physician at Royal Brompton Hospital and an honorary clinical senior lecturer at Imperial College London, London, told Medscape Medical News that this cohort of patients shows symptoms that seem to correlate with a pulmonary microangiopathy phenotype.
"Our clinics in the UK and around the world are full of people with long-COVID, persisting breathlessness, and fatigue. But it has been hard for people to put the finger on why patients experience these symptoms still," Timothy Hinks, associate professor and Wellcome Trust Career Development fellow at the Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre senior research fellow, and honorary consultant at Oxford Special Airway Service at Oxford University Hospitals, England, who was not involved in the study, told Medscape Medical News.
The Study Researchers at Imperial College London recruited 41 patients who experienced persistent post-COVID-19 infection symptoms, such as breathlessness and fatigue, but normal CT scans after a mild COVID-19 infection that did not require hospitalization. Those with pulmonary emboli or interstitial lung disease were excluded. The cohort was predominantly female (87.8%) and nonsmokers (85%), with a mean age of 44.7 years. They were assessed over 1 year after the initial infection.
Exercise intolerance was the predominant symptom, affecting 95.1% of the group. A significant proportion (46.3%) presented with myopericarditis, while a smaller subset (n = 5) exhibited dysautonomia. Echocardiography did not reveal pulmonary hypertension. Laboratory findings showed elevated angiotensin-converting enzyme and antiphospholipid antibodies. "These patients are young, female, nonsmokers, and previously healthy. This is not what you would expect to see," Price said. Baseline pulmonary function tests showed preserved spirometry with forced expiratory volume in 1 second and forced vital capacity above 100% predicted. However, diffusion capacity was impaired, with a mean diffusing capacity of the lungs for carbon monoxide (DLCO) of 74.7%. The carbon monoxide transfer coefficient (KCO) and alveolar volume were also mildly reduced. Oxygen saturation was within normal limits.
These abnormalities were through advanced imaging techniques like dual-energy CT scans and ventilation-perfusion scans. These tests revealed a non-segmental and "patchy" perfusion abnormality in the upper lungs, suggesting that the problem was vascular, Price explained.
Cardiopulmonary exercise testing revealed further abnormalities in 41% of patients. Peak oxygen uptake was slightly reduced, and a significant proportion of patients showed elevated alveolar-arterial gradient and dead space ventilation during peak exercise, suggesting a ventilation-perfusion mismatch.
Over time, there was a statistically significant improvement in DLCO, from 70.4% to 74.4%, suggesting some degree of recovery in lung function. However, DLCO values did not return to normal. The KCO also improved from 71.9% to 74.4%, though this change did not reach statistical significance. Most patients (n = 26) were treated with apixaban, potentially contributing to the observed improvement in gas transfer parameters, Price said.
The researchers identified a distinct phenotype of patients with persistent post-COVID-19 infection symptoms characterized by abnormal lung perfusion and reduced gas diffusion capacity, even when CT scans appear normal. Price explains that this pulmonary microangiopathy may explain the persistent symptoms. However, questions remain about the underlying mechanisms, potential treatments, and long-term outcomes for this patient population.
Causes and Treatments Remain a Mystery Previous studies have suggested that COVID-19 causes endothelial dysfunction, which could affect the small blood vessels in the lungs. Other viral infections, such as HIV, have also been shown to cause endothelial dysfunction. However, researchers don't fully understand how this process plays out in patients with COVID-19.
"It is possible these patients have had inflammation insults that have damaged the pulmonary vascular endothelium, which predisposes them to either clotting at a microscopic level or ongoing inflammation," said Hinks.
Some patients (10 out of 41) in the cohort studied by the Imperial College London's researchers presented with Raynaud syndrome, which might suggest a physiological link, Hinks explains. "Raynaud's is a condition of vascular control or dysregulation, and potentially, there could be a common factor contributing to both breathlessness and Raynaud's."
He said there is an encouraging signal that these patients improve over time, but their recovery might be more complex and lengthy than for other patients. "This cohort will gradually get better. But it raises questions and gives a point that there is a true physiological deficit in some people with long-COVID."
Price encouraged physicians to look beyond conventional diagnostic tools when visiting a patient whose CT scan looks normal yet experiences fatigue and breathlessness. Not knowing what causes the abnormalities observed in this group of patients makes treatment extremely challenging. "We need more research to understand the treatment implications and long-term impact of these pulmonary vascular abnormalities in patients with long-COVID," Price concluded.
#long covid#covid#covid news#mask up#pandemic#covid 19#wear a mask#public health#sars cov 2#still coviding#coronavirus#wear a respirator#covid conscious#covid is airborne#covid isn't over#covid pandemic#covid19#covidー19
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ROS vs Bacteria
Inducing lung lining cells to produce bacteria-killing reactive oxygen species (highly reactive chemicals that can cause oxidative damage) protects against pneumonia without reliance on antibiotics
Read the published research paper here
Image from work by Yongxing Wang and colleagues
Department of Pulmonary Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA
Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
Published in PLOS Pathogens, September 2023
You can also follow BPoD on Instagram, Twitter and Facebook
#science#biomedicine#immunofluorescence#biology#reactive oxygen species#ROS#sci art#pulmonary#lungs#pneumonia#antibiotics#antibiotic resistance
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Dr. Jonathan Altus, MD | Expert Orthopedic Care & Sports Medicine
Welcome to the website of Dr. Jonathan D. Altus, a board-certified pulmonologist. Recognized as a Top Doctor by Castle Connolly, Dr. Altus specializes in pulmonary and critical care medicine at South Nassau Communities Hospital. Visit us today.
Expert Orthopedic Care & Sports Medicine
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Best Lungs Specialist in Hyderabad – Expert Pulmonary Care at TX Hospitals
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If you are looking for the best lungs specialist in Hyderabad, TX Hospitals is your trusted destination for advanced pulmonary care. With a team of highly skilled lung specialists, we offer world-class treatment for various respiratory conditions, including asthma, chronic obstructive pulmonary disease (COPD), lung infections, and more. Our state-of-the-art facilities and expert medical professionals ensure that you receive the best care for your lung health.
Why Choose TX Hospitals for Lung Care?
At TX Hospitals, we are committed to providing top-notch pulmonary care through:
✔ Expert Lungs Specialists – Our experienced pulmonologists diagnose and treat a wide range of lung diseases. ✔ Advanced Diagnostic Technology – We use cutting-edge tools like pulmonary function tests (PFTs), CT scans, and bronchoscopy for accurate diagnosis. ✔ Comprehensive Treatment Plans – Personalized care tailored to each patient’s condition for effective management. ✔ 24/7 Emergency Support – Immediate assistance for critical lung conditions like asthma attacks and respiratory failure.
Meet the Best Lungs Specialists in Hyderabad
Dr. B. Vijay Bhaskar – Leading Lungs Specialist
Qualifications: MBBS, MD (General Medicine), DM (Pulmonary Medicine) Expertise: Specializes in COPD, interstitial lung diseases, and lung infections.
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Qualifications: MBBS, DNB, FCCM Expertise: Expert in critical respiratory care, sleep apnea, and chronic lung conditions.
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Qualifications: MBBS, MD (Pulmonary Medicine) Expertise: Focuses on asthma, pneumonia, and occupational lung diseases.
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Qualifications: MBBS, MD, IDCCM Expertise: Specializes in lung infections, bronchitis, and sleep disorders.
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Conditions We Treat
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🔹 Asthma and respiratory allergies 🔹 Chronic Obstructive Pulmonary Disease (COPD) 🔹 Pneumonia and lung infections 🔹 Tuberculosis and interstitial lung diseases 🔹 Sleep apnea and snoring disorders 🔹 Bronchitis and emphysema 🔹 Lung cancer diagnosis and management
Book an Appointment with the Best Lungs Specialist in Hyderabad
Your lungs play a vital role in your overall health. If you are facing breathing difficulties, chronic cough, or any lung-related issues, consult the best lungs specialist in Hyderabad at TX Hospitals today. Our specialists are dedicated to providing top-quality care to ensure better respiratory health.
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#chest specialist hyderabad#best lungs specialist in hyderabad#lungs specialist hospital in hyderabad#lungs specialist doctor in hyderabad#best chest specialist in hyderabad#chest specialist doctor in hyderabad#lungs specialist in hyderabad near me
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Dr. Rajendra Prasad | A Legacy of Excellence in Pulmonary Medicine | Story in His Own Words
Professor (Dr.) Rajendra Prasad is Member of the Internal Advisory Committee of Help U Educational and Charitable Trust.
Prof. Rajendra Prasad is a towering figure in the field of Pulmonary Medicine in India. As the Director of Medical Education and Professor, Department of Respiratory Medicine at Era’s Lucknow Medical College and Hospital, and Emeritus Professor, National Academy of Medical Sciences, India, his contributions have left an indelible mark on medical education, research, and patient care.
With an illustrious career spanning nearly five decades, Prof. Prasad has held prestigious positions including Director, Vallabhbhai Patel Chest Institute (VPCI), Delhi, Head of Pulmonary Medicine, King George’s Medical University (KGMU), Lucknow, and Director, U.P. Rural Institute of Medical Sciences and Research, Saifai. His academic journey began at KGMU, Lucknow, where he earned his MBBS in 1974 and MD in 1979, later advancing his expertise in Pulmonary Medicine, Fiberoptic Bronchoscopy, and Lung Cancer from Japan.
A pioneer in Tuberculosis research and control, Prof. Prasad played a key role in shaping the Revised National Tuberculosis Control Programme (RNTCP), now known as the National Tuberculosis Elimination Programme (NTEP). He was instrumental in establishing the DOTS Center at KGMU, one of the first medical college-based centers in India, and has been a leading advocate for engaging both government and private medical colleges in the fight against TB. His commitment has earned him a place as Vice Chairman of the National Task Force for Medical Colleges in NTEP and Chairman of the Uttar Pradesh Tuberculosis Association.
Prof. Prasad's influence extends beyond India—he has served as the International Governor of the American College of Chest Physicians (USA) and is a respected authority worldwide. He holds the unique distinction of having presided over all major Indian scientific bodies in Pulmonary Medicine, including:
National College of Chest Physicians, India
Indian Chest Society
Indian College of Allergy, Asthma & Applied Immunology
Indian Association for Bronchology
Tuberculosis Association of India
His contributions to medical literature are unparalleled, having supervised over 215 research studies and published 600 original articles, reviews, and book chapters. He is the author of 12 books, including four on Tuberculosis, an Atlas on Fiberoptic Bronchoscopy, and the Manual of Chest X-rays, uniquely based on Indian patients. His research excellence has been globally recognized—Stanford University ranked him among the top 2% of scientists worldwide in both career-long and recent-year rankings, with 7,632 citations, an H-index of 45, and an i10-index exceeding 182.
Prof. Prasad’s passion for medical education, patient care, and research has led to transformative developments. Under his leadership at KGMU, he established multiple specialized services, including:
Video Bronchoscopy (First in Uttar Pradesh)
Medical Thoracoscopy
Thoracic Oncology Unit
Air Pollution-Related Disease Diagnostic Center
Sleep Lab
This exceptional contribution has earned him the title of “Father of Pulmonary Medicine” in Uttar Pradesh. His students, now esteemed pulmonologists across India, consider him an inspiring mentor.
His relentless dedication to advancing medicine and public health has been recognized through over 75 prestigious awards, including:
Dr. B.C. Roy National Award
Lifetime Achievement Awards from multiple national organizations
Vigyan Gaurav Award (Council of Science & Technology, Government of Uttar Pradesh)
UP Ratna Award
O.A. Sarma Oration Award
M. Santosham Oration Award
Dr. Reddy’s Lung Cancer Oration Award
Dr. R.V. Rajam Academic Oration Award (National Academy of Medical Sciences, India)
Prof. Rajendra Prasad’s journey is a testament to excellence, perseverance, and an unwavering commitment to medical science. His legacy continues to shape the future of Pulmonary Medicine, inspiring generations of doctors, researchers, and healthcare leaders worldwide.
#DrRajendraPrasad #PulmonaryMedicine #MedicalEducation #TuberculosisControl #NTEP #RespiratoryHealth #MedicalResearch #PublicHealth #ChestPhysician #MedicalLeadership #HealthcareInnovation #TBElimination #LungHealth #MedicalMentor #LifesavingScience #IndianMedicalExcellence #MedicalPioneer #GlobalHealthcare #HealthcareHero
#narendramodi #PMOIndia
#YogiAdityanath #UPCM
#IACM #InternalAdvisoryCommitteeMember
#helputrust #HelpUEducationalandCharitableTrust
#KiranAgarwal #DrRupalAgarwal #HarshVardhanAgarwal
#followers #highlight #topfans
www.helputrust.org
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Dr. Rajendra Prasad | A Legacy of Excellence in Pulmonary Medicine | Story in His Own Words
Professor (Dr.) Rajendra Prasad is Member of the Internal Advisory Committee of Help U Educational and Charitable Trust.
Prof. Rajendra Prasad is a towering figure in the field of Pulmonary Medicine in India. As the Director of Medical Education and Professor, Department of Respiratory Medicine at Era’s Lucknow Medical College and Hospital, and Emeritus Professor, National Academy of Medical Sciences, India, his contributions have left an indelible mark on medical education, research, and patient care.
With an illustrious career spanning nearly five decades, Prof. Prasad has held prestigious positions including Director, Vallabhbhai Patel Chest Institute (VPCI), Delhi, Head of Pulmonary Medicine, King George’s Medical University (KGMU), Lucknow, and Director, U.P. Rural Institute of Medical Sciences and Research, Saifai. His academic journey began at KGMU, Lucknow, where he earned his MBBS in 1974 and MD in 1979, later advancing his expertise in Pulmonary Medicine, Fiberoptic Bronchoscopy, and Lung Cancer from Japan.
A pioneer in Tuberculosis research and control, Prof. Prasad played a key role in shaping the Revised National Tuberculosis Control Programme (RNTCP), now known as the National Tuberculosis Elimination Programme (NTEP). He was instrumental in establishing the DOTS Center at KGMU, one of the first medical college-based centers in India, and has been a leading advocate for engaging both government and private medical colleges in the fight against TB. His commitment has earned him a place as Vice Chairman of the National Task Force for Medical Colleges in NTEP and Chairman of the Uttar Pradesh Tuberculosis Association.
Prof. Prasad's influence extends beyond India—he has served as the International Governor of the American College of Chest Physicians (USA) and is a respected authority worldwide. He holds the unique distinction of having presided over all major Indian scientific bodies in Pulmonary Medicine, including:
National College of Chest Physicians, India
Indian Chest Society
Indian College of Allergy, Asthma & Applied Immunology
Indian Association for Bronchology
Tuberculosis Association of India
His contributions to medical literature are unparalleled, having supervised over 215 research studies and published 600 original articles, reviews, and book chapters. He is the author of 12 books, including four on Tuberculosis, an Atlas on Fiberoptic Bronchoscopy, and the Manual of Chest X-rays, uniquely based on Indian patients. His research excellence has been globally recognized—Stanford University ranked him among the top 2% of scientists worldwide in both career-long and recent-year rankings, with 7,632 citations, an H-index of 45, and an i10-index exceeding 182.
Prof. Prasad’s passion for medical education, patient care, and research has led to transformative developments. Under his leadership at KGMU, he established multiple specialized services, including:
Video Bronchoscopy (First in Uttar Pradesh)
Medical Thoracoscopy
Thoracic Oncology Unit
Air Pollution-Related Disease Diagnostic Center
Sleep Lab
This exceptional contribution has earned him the title of “Father of Pulmonary Medicine” in Uttar Pradesh. His students, now esteemed pulmonologists across India, consider him an inspiring mentor.
His relentless dedication to advancing medicine and public health has been recognized through over 75 prestigious awards, including:
Dr. B.C. Roy National Award
Lifetime Achievement Awards from multiple national organizations
Vigyan Gaurav Award (Council of Science & Technology, Government of Uttar Pradesh)
UP Ratna Award
O.A. Sarma Oration Award
M. Santosham Oration Award
Dr. Reddy’s Lung Cancer Oration Award
Dr. R.V. Rajam Academic Oration Award (National Academy of Medical Sciences, India)
Prof. Rajendra Prasad’s journey is a testament to excellence, perseverance, and an unwavering commitment to medical science. His legacy continues to shape the future of Pulmonary Medicine, inspiring generations of doctors, researchers, and healthcare leaders worldwide.
#DrRajendraPrasad #PulmonaryMedicine #MedicalEducation #TuberculosisControl #NTEP #RespiratoryHealth #MedicalResearch #PublicHealth #ChestPhysician #MedicalLeadership #HealthcareInnovation #TBElimination #LungHealth #MedicalMentor #LifesavingScience #IndianMedicalExcellence #MedicalPioneer #GlobalHealthcare #HealthcareHero
#narendramodi #PMOIndia
#YogiAdityanath #UPCM
#IACM #InternalAdvisoryCommitteeMember
#helputrust #HelpUEducationalandCharitableTrust
#KiranAgarwal #DrRupalAgarwal #HarshVardhanAgarwal
#followers #highlight #topfans
www.helputrust.org
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Dr. Rajendra Prasad | A Legacy of Excellence in Pulmonary Medicine | Story in His Own Words
Professor (Dr.) Rajendra Prasad is Member of the Internal Advisory Committee of Help U Educational and Charitable Trust.
Prof. Rajendra Prasad is a towering figure in the field of Pulmonary Medicine in India. As the Director of Medical Education and Professor, Department of Respiratory Medicine at Era’s Lucknow Medical College and Hospital, and Emeritus Professor, National Academy of Medical Sciences, India, his contributions have left an indelible mark on medical education, research, and patient care.
With an illustrious career spanning nearly five decades, Prof. Prasad has held prestigious positions including Director, Vallabhbhai Patel Chest Institute (VPCI), Delhi, Head of Pulmonary Medicine, King George’s Medical University (KGMU), Lucknow, and Director, U.P. Rural Institute of Medical Sciences and Research, Saifai. His academic journey began at KGMU, Lucknow, where he earned his MBBS in 1974 and MD in 1979, later advancing his expertise in Pulmonary Medicine, Fiberoptic Bronchoscopy, and Lung Cancer from Japan.
A pioneer in Tuberculosis research and control, Prof. Prasad played a key role in shaping the Revised National Tuberculosis Control Programme (RNTCP), now known as the National Tuberculosis Elimination Programme (NTEP). He was instrumental in establishing the DOTS Center at KGMU, one of the first medical college-based centers in India, and has been a leading advocate for engaging both government and private medical colleges in the fight against TB. His commitment has earned him a place as Vice Chairman of the National Task Force for Medical Colleges in NTEP and Chairman of the Uttar Pradesh Tuberculosis Association.
Prof. Prasad's influence extends beyond India—he has served as the International Governor of the American College of Chest Physicians (USA) and is a respected authority worldwide. He holds the unique distinction of having presided over all major Indian scientific bodies in Pulmonary Medicine, including:
National College of Chest Physicians, India
Indian Chest Society
Indian College of Allergy, Asthma & Applied Immunology
Indian Association for Bronchology
Tuberculosis Association of India
His contributions to medical literature are unparalleled, having supervised over 215 research studies and published 600 original articles, reviews, and book chapters. He is the author of 12 books, including four on Tuberculosis, an Atlas on Fiberoptic Bronchoscopy, and the Manual of Chest X-rays, uniquely based on Indian patients. His research excellence has been globally recognized—Stanford University ranked him among the top 2% of scientists worldwide in both career-long and recent-year rankings, with 7,632 citations, an H-index of 45, and an i10-index exceeding 182.
Prof. Prasad’s passion for medical education, patient care, and research has led to transformative developments. Under his leadership at KGMU, he established multiple specialized services, including:
Video Bronchoscopy (First in Uttar Pradesh)
Medical Thoracoscopy
Thoracic Oncology Unit
Air Pollution-Related Disease Diagnostic Center
Sleep Lab
This exceptional contribution has earned him the title of “Father of Pulmonary Medicine” in Uttar Pradesh. His students, now esteemed pulmonologists across India, consider him an inspiring mentor.
His relentless dedication to advancing medicine and public health has been recognized through over 75 prestigious awards, including:
Dr. B.C. Roy National Award
Lifetime Achievement Awards from multiple national organizations
Vigyan Gaurav Award (Council of Science & Technology, Government of Uttar Pradesh)
UP Ratna Award
O.A. Sarma Oration Award
M. Santosham Oration Award
Dr. Reddy’s Lung Cancer Oration Award
Dr. R.V. Rajam Academic Oration Award (National Academy of Medical Sciences, India)
Prof. Rajendra Prasad’s journey is a testament to excellence, perseverance, and an unwavering commitment to medical science. His legacy continues to shape the future of Pulmonary Medicine, inspiring generations of doctors, researchers, and healthcare leaders worldwide.
#DrRajendraPrasad #PulmonaryMedicine #MedicalEducation #TuberculosisControl #NTEP #RespiratoryHealth #MedicalResearch #PublicHealth #ChestPhysician #MedicalLeadership #HealthcareInnovation #TBElimination #LungHealth #MedicalMentor #LifesavingScience #IndianMedicalExcellence #MedicalPioneer #GlobalHealthcare #HealthcareHero
#narendramodi #PMOIndia
#YogiAdityanath #UPCM
#IACM #InternalAdvisoryCommitteeMember
#helputrust #HelpUEducationalandCharitableTrust
#KiranAgarwal #DrRupalAgarwal #HarshVardhanAgarwal
#followers #highlight #topfans
www.helputrust.org
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Dr. Rajendra Prasad | A Legacy of Excellence in Pulmonary Medicine | Story in His Own Words
Professor (Dr.) Rajendra Prasad is Member of the Internal Advisory Committee of Help U Educational and Charitable Trust.
Prof. Rajendra Prasad is a towering figure in the field of Pulmonary Medicine in India. As the Director of Medical Education and Professor, Department of Respiratory Medicine at Era’s Lucknow Medical College and Hospital, and Emeritus Professor, National Academy of Medical Sciences, India, his contributions have left an indelible mark on medical education, research, and patient care.
With an illustrious career spanning nearly five decades, Prof. Prasad has held prestigious positions including Director, Vallabhbhai Patel Chest Institute (VPCI), Delhi, Head of Pulmonary Medicine, King George’s Medical University (KGMU), Lucknow, and Director, U.P. Rural Institute of Medical Sciences and Research, Saifai. His academic journey began at KGMU, Lucknow, where he earned his MBBS in 1974 and MD in 1979, later advancing his expertise in Pulmonary Medicine, Fiberoptic Bronchoscopy, and Lung Cancer from Japan.
A pioneer in Tuberculosis research and control, Prof. Prasad played a key role in shaping the Revised National Tuberculosis Control Programme (RNTCP), now known as the National Tuberculosis Elimination Programme (NTEP). He was instrumental in establishing the DOTS Center at KGMU, one of the first medical college-based centers in India, and has been a leading advocate for engaging both government and private medical colleges in the fight against TB. His commitment has earned him a place as Vice Chairman of the National Task Force for Medical Colleges in NTEP and Chairman of the Uttar Pradesh Tuberculosis Association.
Prof. Prasad's influence extends beyond India—he has served as the International Governor of the American College of Chest Physicians (USA) and is a respected authority worldwide. He holds the unique distinction of having presided over all major Indian scientific bodies in Pulmonary Medicine, including:
National College of Chest Physicians, India
Indian Chest Society
Indian College of Allergy, Asthma & Applied Immunology
Indian Association for Bronchology
Tuberculosis Association of India
His contributions to medical literature are unparalleled, having supervised over 215 research studies and published 600 original articles, reviews, and book chapters. He is the author of 12 books, including four on Tuberculosis, an Atlas on Fiberoptic Bronchoscopy, and the Manual of Chest X-rays, uniquely based on Indian patients. His research excellence has been globally recognized—Stanford University ranked him among the top 2% of scientists worldwide in both career-long and recent-year rankings, with 7,632 citations, an H-index of 45, and an i10-index exceeding 182.
Prof. Prasad’s passion for medical education, patient care, and research has led to transformative developments. Under his leadership at KGMU, he established multiple specialized services, including:
Video Bronchoscopy (First in Uttar Pradesh)
Medical Thoracoscopy
Thoracic Oncology Unit
Air Pollution-Related Disease Diagnostic Center
Sleep Lab
This exceptional contribution has earned him the title of “Father of Pulmonary Medicine” in Uttar Pradesh. His students, now esteemed pulmonologists across India, consider him an inspiring mentor.
His relentless dedication to advancing medicine and public health has been recognized through over 75 prestigious awards, including:
Dr. B.C. Roy National Award
Lifetime Achievement Awards from multiple national organizations
Vigyan Gaurav Award (Council of Science & Technology, Government of Uttar Pradesh)
UP Ratna Award
O.A. Sarma Oration Award
M. Santosham Oration Award
Dr. Reddy’s Lung Cancer Oration Award
Dr. R.V. Rajam Academic Oration Award (National Academy of Medical Sciences, India)
Prof. Rajendra Prasad’s journey is a testament to excellence, perseverance, and an unwavering commitment to medical science. His legacy continues to shape the future of Pulmonary Medicine, inspiring generations of doctors, researchers, and healthcare leaders worldwide.
#DrRajendraPrasad #PulmonaryMedicine #MedicalEducation #TuberculosisControl #NTEP #RespiratoryHealth #MedicalResearch #PublicHealth #ChestPhysician #MedicalLeadership #HealthcareInnovation #TBElimination #LungHealth #MedicalMentor #LifesavingScience #IndianMedicalExcellence #MedicalPioneer #GlobalHealthcare #HealthcareHero
#narendramodi #PMOIndia
#YogiAdityanath #UPCM
#IACM #InternalAdvisoryCommitteeMember
#helputrust #HelpUEducationalandCharitableTrust
#KiranAgarwal #DrRupalAgarwal #HarshVardhanAgarwal
#followers #highlight #topfans
www.helputrust.org
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Dr. Rajendra Prasad | A Legacy of Excellence in Pulmonary Medicine | Story in His Own Words
Professor (Dr.) Rajendra Prasad is Member of the Internal Advisory Committee of Help U Educational and Charitable Trust.
Prof. Rajendra Prasad is a towering figure in the field of Pulmonary Medicine in India. As the Director of Medical Education and Professor, Department of Respiratory Medicine at Era’s Lucknow Medical College and Hospital, and Emeritus Professor, National Academy of Medical Sciences, India, his contributions have left an indelible mark on medical education, research, and patient care.
With an illustrious career spanning nearly five decades, Prof. Prasad has held prestigious positions including Director, Vallabhbhai Patel Chest Institute (VPCI), Delhi, Head of Pulmonary Medicine, King George’s Medical University (KGMU), Lucknow, and Director, U.P. Rural Institute of Medical Sciences and Research, Saifai. His academic journey began at KGMU, Lucknow, where he earned his MBBS in 1974 and MD in 1979, later advancing his expertise in Pulmonary Medicine, Fiberoptic Bronchoscopy, and Lung Cancer from Japan.
A pioneer in Tuberculosis research and control, Prof. Prasad played a key role in shaping the Revised National Tuberculosis Control Programme (RNTCP), now known as the National Tuberculosis Elimination Programme (NTEP). He was instrumental in establishing the DOTS Center at KGMU, one of the first medical college-based centers in India, and has been a leading advocate for engaging both government and private medical colleges in the fight against TB. His commitment has earned him a place as Vice Chairman of the National Task Force for Medical Colleges in NTEP and Chairman of the Uttar Pradesh Tuberculosis Association.
Prof. Prasad's influence extends beyond India—he has served as the International Governor of the American College of Chest Physicians (USA) and is a respected authority worldwide. He holds the unique distinction of having presided over all major Indian scientific bodies in Pulmonary Medicine, including:
National College of Chest Physicians, India
Indian Chest Society
Indian College of Allergy, Asthma & Applied Immunology
Indian Association for Bronchology
Tuberculosis Association of India
His contributions to medical literature are unparalleled, having supervised over 215 research studies and published 600 original articles, reviews, and book chapters. He is the author of 12 books, including four on Tuberculosis, an Atlas on Fiberoptic Bronchoscopy, and the Manual of Chest X-rays, uniquely based on Indian patients. His research excellence has been globally recognized—Stanford University ranked him among the top 2% of scientists worldwide in both career-long and recent-year rankings, with 7,632 citations, an H-index of 45, and an i10-index exceeding 182.
Prof. Prasad’s passion for medical education, patient care, and research has led to transformative developments. Under his leadership at KGMU, he established multiple specialized services, including:
Video Bronchoscopy (First in Uttar Pradesh)
Medical Thoracoscopy
Thoracic Oncology Unit
Air Pollution-Related Disease Diagnostic Center
Sleep Lab
This exceptional contribution has earned him the title of “Father of Pulmonary Medicine” in Uttar Pradesh. His students, now esteemed pulmonologists across India, consider him an inspiring mentor.
His relentless dedication to advancing medicine and public health has been recognized through over 75 prestigious awards, including:
Dr. B.C. Roy National Award
Lifetime Achievement Awards from multiple national organizations
Vigyan Gaurav Award (Council of Science & Technology, Government of Uttar Pradesh)
UP Ratna Award
O.A. Sarma Oration Award
M. Santosham Oration Award
Dr. Reddy’s Lung Cancer Oration Award
Dr. R.V. Rajam Academic Oration Award (National Academy of Medical Sciences, India)
Prof. Rajendra Prasad’s journey is a testament to excellence, perseverance, and an unwavering commitment to medical science. His legacy continues to shape the future of Pulmonary Medicine, inspiring generations of doctors, researchers, and healthcare leaders worldwide.
#DrRajendraPrasad #PulmonaryMedicine #MedicalEducation #TuberculosisControl #NTEP #RespiratoryHealth #MedicalResearch #PublicHealth #ChestPhysician #MedicalLeadership #HealthcareInnovation #TBElimination #LungHealth #MedicalMentor #LifesavingScience #IndianMedicalExcellence #MedicalPioneer #GlobalHealthcare #HealthcareHero
#narendramodi #PMOIndia
#YogiAdityanath #UPCM
#IACM #InternalAdvisoryCommitteeMember
#helputrust #HelpUEducationalandCharitableTrust
#KiranAgarwal #DrRupalAgarwal #HarshVardhanAgarwal
#followers #highlight #topfans
www.helputrust.org
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Best Pulmonologists in Battarahalli, Bangalore
Do you experience difficulties breathing, having cough, or chest pain? These symptoms could suggest severe conditions such as asthma, COPD, or sleep apnea. To promote good respiratory health, it is of utmost importance to ensure early diagnosis and expert management.
At Hope Hospital, we render modern-specific world-class pulmonology service. We have Dr. Ayana K one of the best pulmonologists in Battarahalli, Bangalore-will assist in accurate diagnosis and the provision of personalized therapeutic care for different lung disorders. Having MBBS and MD in Respiratory Medicine, she has been treating patients for seven years and is known for her expertise in asthma, COPD, lung infections, and sleep apnea, like pulmonary disorders.
We provide specially tailored treatment plans that include therapy, lifestyle changes, and cessation programs that will aid in the restoration of lung function.
Are you looking for one of the best pulmonologists in Battarahalli, Bangalore? Then book your appointment with Dr. Ayana K at Hope Hospital and take a step toward healthier lungs. Breathe free; live healthy!
#medicalcare#bengaluruhealthcare#PulmonologistInBangalore#AsthmaTreatment#ChestSpecialist#PulmonaryCare#BreathEasy
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The Best pulmonologists in Battarahalli, Bangalore-Meet Dr. Ayana K
Finding the proper specialist is beneficial for respiratory health. If you’re seeking for the Best pulmonologist in Battarahalli, Bangalore, Dr. Ayana K at Hope Hospital is the name to know. Dr. Ayana K has a solid reputation for providing excellent pulmonary treatment due to her comprehensive training in lung medicine and years of expertise treating lung-related diseases.
About Battarahalli’s Best Pulmonologist, Dr. Ayana K.
Dr. Ayana K, a 35-year-old pulmonologist at Hope Hospital, Battarahalli, Bangalore with solid knowledge in lung medicine, is extremely capable. With her MBBS and MD in Lung Medicine, she is qualified to identify and treat a range of lung diseases. She is one of the best pulmonologists in Battarahalli, Bangalore because to her dedication to patient care and advanced treatment techniques.
Why Choose Dr. Ayana K for Your Respiratory Health?
Knowledge of Respiratory Medicine Dr. Ayana K. has a wealth of knowledge on the diagnosis and treatment of respiratory conditions, including apnea for sleep, asthma, COPD, pneumonia, TB, and interstitial bronchitis.
Advanced Procedures for Diagnosis and Treatment
To ensure a precise diagnosis and successful treatment, she uses latest diagnostic methods such as bronchoscopy, sleep studies, and pulmonary function tests (PFTs).
The patient focused method
In order to ensure that patients receive individualized care treatments that are suited to their individual needs, Dr. Ayana K. believes in treating patients completely.
knowledgeable about critical care pulmonary
She is a dependable option for complicated cases because of her practical experience with critical care ventilation, respiratory emergencies, and ICU-based pulmonary treatments.
Dr. Ayana K. treats a wide range of conditions, others including asthma for which she helps her patients with the use of inhalers, medication, and changes in lifestyle in order to control it.
Providing medical care for COPD to help patients breathe easier and enjoy life better. Tuberculosis (TB): Diagnosing and treating TB with the latest medicines and appliances for follow up.
Pneumonia & Lung Infections: Caring with great expertise all types of lung infections due to viruses and bacteria.
Sleep Apnea & Snoring Issues: Giving studies on sleep and providing CPAP therapy for sleep-related diseases.
Where Can I Speak with Dr. Ayana K?
Dr. Ayana K makes sure that patients have easy access to excellent pulmonary treatment by working in Hope hospital in Battarahalli, Bangalore. To schedule a consultation with one of Battarahalli’s top pulmonologists, you may either contact or visit Hope Hospital.
Conclusion
It is important to consult with qualified medical care if you are having breathing issues, have an ongoing cough, or have any other lung-related illnesses. With an MD in Respiratory Medicine and an MBBS, Dr. Ayana K is one of the best pulmonologists in Battarahalli, Bangalore, in Hope Hospital and can give you the right diagnosis and treatment. Make your lung health a priority right now by speaking with a trusted doctor like Dr. Ayana K.
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Also preserved on our archive
Some interesting science analyzed
BY BROOKS LEITNER
Imagine lying back in an enclosed chamber where you bask for 90 minutes in a sea of pure oxygen at pressures two to three times that felt at sea level. This is the world of hyperbaric oxygen therapy (HBOT), a technology that’s been around for decades and is now being explored as a possible treatment for Long COVID.
"The silence on the inside is deafening at first,” says John M.,* who has undergone dozens of HBOT treatments for his persistent Long COVID symptoms. Fortunately, there is a television outside the chamber in view, and it is easy to communicate with the provider if needed. While the potential protocol is still being refined, patients may undergo up to 40 HBOT sessions to address some of the most problematic, lingering symptoms of this complex condition.
HBOT is a therapeutic process that has been widely used to treat such conditions as decompression sickness in scuba divers, carbon monoxide poisoning, and diabetic foot ulcers. In HBOT, the body is exposed to 100% oxygen, a significant increase from the 21% oxygen concentration we typically breathe. The therapy takes place in an enclosed chamber where the air pressure is elevated above normal levels. The combination of high-pressure and high-oxygen conditions enhances the amount of oxygen that can reach the body's tissues. The hope is that this therapy can provide the same relief and healing to people with Long COVID that it does for those with other conditions.
According to John M., HBOT was the first treatment that helped with his sleep and reduced his heart palpitations. “At one point after hospitalization, my Long COVID symptoms were so bad that I could barely walk or talk. HBOT was a great tool that really assisted with my recovery,” he said. John added that he hopes the medical community will achieve a better understanding of how HBOT can help relieve suffering for patients with Long COVID and that more research will increase access to this innovative therapy.
Does HBOT improve Long COVID symptoms? One key observation from the work of Inderjit Singh, MBChB, an assistant professor at Yale School of Medicine (YSM) specializing in pulmonary, critical care, and sleep medicine, is that Long COVID patients often experience debilitating fatigue. Based on Dr. Singh’s previous Long COVID research, the exhaustion is thought to be linked to the muscles’ inability to efficiently extract and utilize oxygen.
To picture how HBOT might work, you can think of your muscles as engines sputtering, struggling to get the fuel they need. If oxygen is the gas that fuels the muscles, it’s as if you are trying to complete your daily routine while the gas tank is running on “empty.” By aiming to directly address this oxygen utilization impairment, HBOT may be a potential solution.
A systematic review by researchers at the China Medical University Hospital noted that HBOT could tackle another major factor in the Long COVID puzzle: oxidative stress. This relates to the body's struggle to maintain balance when harmful molecules, known as free radicals, run amok, causing chronic inflammation.
Research co-authored by Sandra K. Wainwright, MD, medical director of the Center for Hyperbaric Medicine and Wound Healing at Greenwich Hospital in Connecticut, suggests that HBOT, with its high-oxygen environment, might dampen this chronic inflammation by improving mitochondrial activity and decreasing production of harmful molecules. Other potential benefits of HBOT in the treatment of Long COVID may include restoration of oxygen to oxygen-starved tissues, reduced production of inflammatory cytokines, and increased mobilization of hematopoietic stem cells—primary cells that transform into red blood cells, white blood cells, and platelets.
HBOT for Long COVID: Current and ongoing research Several small-scale reports have indicated that HBOT is safe for patients with Long COVID.
To address this question, a trial that followed the gold standard of modern medical research—a randomized, placebo-controlled, double-blind design—assigned 73 Long COVID patients to either receive 40 sessions of HBOT or a placebo of only 21% oxygen. The study observed positive changes in attention, sleep quality, pain symptoms, and energy levels among participants receiving HBOT. In a longitudinal follow-up study published in Scientific Reports, the authors at the Tel Aviv University found that clinical improvements persisted even one year after the last HBOT session was concluded. In a second study, the same authors focused on heart function, measured by an echocardiogram, and found a significant reduction in heart strain, known as global longitudinal strain, in patients who received HBOT.
In another study, 10 patients with Long COVID underwent 10 HBOT treatments over 12 consecutive days. Testing showed statistically significant improvement in fatigue and cognitive function. Meanwhile, an ongoing trial at the Karolinska Institute in Sweden has reported interim safety results wherein almost half of the Long COVID patients in the trial reported cough or chest discomfort during treatment. However, it was unclear whether HBOT exacerbated this symptom or if this adverse effect was due to the effort of participation by patients suffering from more severe Long COVID symptoms.
Is HBOT currently available as a treatment for Long COVID? For HBOT to become a mainstream treatment option for Long COVID, several critical priorities must be addressed. First, there is currently no established method for tailoring HBOT dosages to individual patients, so researchers must learn more about the specific features or symptoms that indicate potential benefits from HBOT. At the same time, we need to identify factors that may be associated with any adverse outcomes of HBOT. And finally, it’s important to determine how long these potentially beneficial effects last in a larger cohort. Will just a few HBOT trials be enough to restore patients to their baseline health, or will HBOT become a recurring component of their annual treatment regimen?
For now, HBOT remains an experimental therapy—and as such is not covered by insurance. This is a huge issue for patients because the therapy is expensive. According to Dr. Wainwright, a six-week course of therapy can run around $60,000. That’s a lot to pay for a therapy that’s still being studied. In the current completed studies, different treatment frequencies and intensities have been used, but it’s unclear how the treatment conditions affect the patient’s outcome.
“I have had some patients notice improvements after only 10 or 15 treatments, whereas some others need up to 45 treatments before they notice a difference,” notes Dr. Wainwright. “I think that HBOT is offering some promising results in many patients, but it is probably a strong adjunctive treatment to the other spectrum of things Long COVID patients should be doing, like participating in an exercise, rehab, and nutritional program.”
Dr. Singh notes that “a major challenge for research is the heterogeneity of Long COVID. It is hard to determine which symptoms to treat and enroll patients into trials based on them.”
Perhaps treatments that target multiple issues caused by Long COVID, like HBOT, may help overcome this challenge.
*Not his real name.
Brooks Leitner is an MD/PhD candidate at Yale School of Medicine.
The last word from Lisa Sanders, MD: Hyperbaric oxygen therapy (HBOT) is just one of the many existing treatments that are being looked at to treat Long COVID. We see this with many new diseases—trying to use a treatment that is effective in one set of diseases to treat another. And there is reason for optimism: We know that HBOT can deliver high levels of oxygen to tissues in need of oxygen. That’s why it’s used to treat soft tissue wounds. If reduced oxygen uptake is the cause of the devastating fatigue caused by Long COVID, as is suggested by many studies, then perhaps a better delivery system will help at least some patients.
Studies referenced:
bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-023-08002-8
www.ncbi.nlm.nih.gov/pmc/articles/PMC8806311/
www.nature.com/articles/s41598-024-53091-3
www.nature.com/articles/s41598-022-15565-0
www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1354088/full
www.ncbi.nlm.nih.gov/pmc/articles/PMC11051078/#:~:text=Proposed%20Mechanism%20of%20HBOT%20o
#long covid#hbottherapy#HBOT#hyperbaric oxygen therapy#mask up#covid#pandemic#wear a mask#public health#covid 19#still coviding#wear a respirator#coronavirus#sars cov 2
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Chest Specialist Doctor in Hyderabad -TX Hospitals
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When it comes to respiratory health, consulting a qualified chest specialist is paramount. In Hyderabad, TX Hospitals is renowned for its team of experienced pulmonologists dedicated to providing comprehensive care for various chest and respiratory conditions.
Meet Our Expert Chest Specialists:
Dr. B. Vijay Bhaskar With over 40 years of experience, Dr. B. Vijay Bhaskar holds an MBBS, MD in General Medicine, and DM in Pulmonary Medicine. He specializes in lung surgery, treatment of chronic obstructive pulmonary disease (COPD), bronchoscopy, and management of lung infections and tuberculosis. Dr. Bhaskar's extensive expertise ensures personalized care for patients with diverse respiratory ailments.
Dr. M. Sai Sashank Dr. M. Sai Sashank, an MBBS and MD graduate, brings over 8 years of experience in pulmonology. His areas of expertise include interventional pulmonology, respiratory medicine, and management of tuberculosis and chest diseases. Dr. Sashank is also proficient in sleep medicine, addressing disorders such as sleep apnea to enhance patients' quality of life. TX Hospitals
Why Choose TX Hospitals?
Comprehensive Care: Our pulmonology department offers a wide range of services, from diagnosis to advanced treatment options, ensuring holistic care for all respiratory conditions.
Advanced Treatments: We specialize in cutting-edge procedures like bronchial thermoplasty for severe asthma and provide facilities for lung transplants, supported by a multidisciplinary team of experts. TX Hospitals
Patient-Centric Approach: At TX Hospitals, we prioritize patient well-being, offering personalized treatment plans tailored to individual needs.
Contact Us
For expert consultation with a chest specialist doctor in Hyderabad, call TX Hospitals at 9089 48 9089. Our dedicated team is ready to assist you on your path to better respiratory health.
Note: This information is based on available data as of February 21, 2025. For the most current details, please contact TX Hospitals directly.
#best pulmonologist doctor in hyderabad#lungs specialist doctor in hyderabad#chest specialist doctor in hyderabad
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Resolution of QRS-fragmentation: A case report and review of literature by Zhong Yi, MD in Journal of Clinical Case Reports Medical Images and Health Sciences
Abstract
Background: It’s not clear whether the resolution of fQRS can be used to assess the effectiveness of cardiac resynchronization therapy defibrillator (CRT-D) in patients of heart failure with reduced ejection fraction (HFrEF).
Case presentation: Here we report a 78-year-old male patient with HFrEF and refractory ventricular tachycardia (VT), who’s 12-lead electrocardiogram (ECG) showed fQRS in leads V1-V6 with QRS duration of 134 ms on admission. Even though the optimized medication of metoprolol, amiodarone, lidocaine, and berberine was given, the recurrent VT and HFrEF were still refractory. For further management, a CRT-D with multipoint pacing (MPP) function (St. Jude Medical, Sylmar, CA) was considered and implanted. It’s very encouraging that no more VTs and fQRS were recorded 9 hours after a CRT-D with MPP function was implanted, and the left ventricle ejection fraction (LVEF) improved significantly later.
Conclusion: CRT-D with MPP is effective in improving the situation of the patient with ischemic cardiomyopathy and HFrEF, and the fQRS resolution can be considered as a sign of its effectiveness.
Keywords: Fragmented QRS; Heart failure; Cardiac resynchronization therapy; Multipoint pacing
Introduction
Fragmented QRS (fQRS) on the 12-lead electrocardiogram (ECG) is defined as the presence of additional notches buried within the QRS, which is widely accepted as a sign of myocardial infarction scar or fibrosis. [1, 2] The fQRS is derived from the abnormality of ventricular depolarization due to ventricular heterogeneity and derangement of ventricular conduction around the infarction zone or scar. [3-5] And the fQRS is also a sign of left ventricular desynchronization in patients of heart failure with reduced ejection fraction (HFrEF) and the narrow QRS complex (<150 ms). [6] A meta-analysis showed that fQRS on patient’s baseline ECG increased all-cause mortality and major arrhythmic events in HFrEF patients. [7] However, it’s not clear whether the resolution of fQRS is useful to assess the effectiveness of cardiac resynchronization therapy defibrillator (CRT-D) in patients with ischemic cardiomyopathy, especially those CRT-D with multipoint pacing (MPP) function. Here we present an HFrEF patient who had fQRS on his admission ECG and frequent ventricular tachycardia (VT) on his Ambulatory ECG. But no more VT and fQRS were recorded, 9 hours after the implantation of a CRT-D with MPP function. The patient had provided informed consent for publication of this case.
Case presentation
A 78-year-old man presented with a complaint of chest congestion and short of breath lasted for 2 hours on his admission. He had hypertension for 10 years, but his blood pressure was normal on admission without taking any medicine. He had an old myocardial infarction and a coronary artery stent implanted 18 years before, and 2 more stents implanted 10 years before. The patient took a semi-sitting position, the blood pressure was 105/65 mmHg, and the heart rate was 80 bpm. Both lungs were clear, the apex was left out of the normal limit, and slight edema in lower extremities was found. His laboratory examination, including blood routine, hepatic and renal function, electrolyte, coagulation function, and Cardiac troponin I (CTNI), was normal, but the level of brain natriuretic peptide (BNP) elevated to 3082 pg/ml. The ECG showed sinus rhythm, ventricular bigeminy, fQRS in leads V1-V6, QRS duration of 134 ms, and abnormal Q wave in leads V4-V6 (Fig. 1a). His 24-hours Holter monitoring showed 41,320 polymorphic ventricular premature beats (PVCs), which is 42% of the total 98327 beats, and 254 paroxysmal polymorphic VT (Fig. 2a). His chest x-radiography revealed pulmonary congestion, pear-shaped heart and cardio-thoracic proportion of more than 50% (Fig. 3a). His transthoracic echocardiography showed left atrium and ventricle enlargement with the left ventricular end-diastolic diameter of 62 mm; there was a ventricular aneurysm of 5.2×2.0 cm2; there was minor regurgitation of mitral and aortic valves; the left ventricular ejection fraction (LVEF) was 28%. Moreover, no coronary artery or stent stenosis was shown by coronary angiography. We proposed the patient’s primary diagnosis was ischemic cardiomyopathy and HFrEF. Even though the optimized medication of metoprolol, amiodarone, lidocaine, and berberine was given, the recurrent VT and HFrEF were still refractory. For further management, a CRT-D with MPP function (St. Jude Medical, Sylmar, CA) was considered and implanted. It’s very encouraging that 9 hours after the procedure, no VT was monitored again (Fig. 2b); twenty-four hours later, the fQRS was absent and never been recorded after that, and the QRS duration decreased from 134 ms to 122 ms (Fig. 1b). Also, the level of BNP significantly dropped to 357 pg/ml. Furthermore, nine days after the procedure, the LVEF increased to 45%; 30 days later, no pulmonary congestion was found on his Chest x-radiography and the cardio-thoracic proportion improved significantly (Fig. 3b). While, over one year of follow-up, the patient has remained symptom-free of VT and HF.
The patient’s chest x-radiography revealed pulmonary congestion, pear-shaped heart, and cardio-thoracic proportion more than 50% at baseline; (b) There was no pulmonary congestion, and the cardio-thoracic percentage decreased significantly, 30 days after the CRT-D implantation.
Discussion
Considering this patient’s old MI history, we supposed that the possible reason for short of breath on admission was acute myocardial ischemia or acute heart failure. But there was no coronary artery or stent stenosis on his coronary angiography, and the level of CTNI was normal. Combined with clinical signs, chest x-radiography, echocardiographic signs, and elevated levels of BNP, the reason for short of breath was sure to be acute heart failure.
The fQRS is defined as various ‘RSR’ patterns, with or without a Q wave, located in two contiguous leads of a major coronary artery territory. And, the fQRS manifests as an extra R (R’) wave, ≥2 notches in R wave, or ≥2 notches in the down or up-stroke of S wave.[4] It’s reported that fQRS was associated with myocardial infarction scar or fibrosis, and was considered as a sign of old myocardial infarction. [1, 2] The fQRS was also considered as a marker of left ventricular dyssynchrony in HFrEF patients with narrow QRS complex (<150ms). [6] Furthermore, the fQRS was also associated with higher all-cause mortality, and cardiac event rate defined as MI, need for revascularization, VT and cardiac death. [8, 9] The fQRS found in contiguous 3 leads was a significant predictor of the cardiac death or heart failure hospitalization. [9] fQRS increased MAE in HFrEF patients. [7] In this HFrEF patient, the fQRS, with narrow QRS complex of 134 ms, presented on all the 6 precordial leads (V1-V6) on his admission ECG. As it was discussed on the above, the presence of fQRS, with narrow QRS complex on the ECG, was showed that he had left ventricular dyssynchrony caused by myocardial infarction scar or fibrosis. Therefore, our strategy focused on improving the ischemic cardiomyopathy induced HFrEF, and CRT-D with MPP was the best choice for the management of his refractory VT and HFrEF. Practically, the complete resolution of fQRS accompanied by the improvement of HFrEF in a relatively short hospital stay is strong evidence support for the effectiveness of CRT-D with MPP function.
Implantable CRT with MPP is a new quadripolar technology that involves a left ventricle lead with 4 different pacing electrodes and a dedicated device with multiple pacing options. [9] MPP is superior to the conventional biventricular pacing on the improvement of acute cardiac hemodynamics, left ventricle synchronization, and QRS complex narrowing, and all of this manifested as a higher number of acute responders to CRT. [10-12] Therefore, a CRT-D with MPP was implanted in our patient. Then, he had a significant improvement, such as the termination of VT, the narrowing of QRS, the elevation of LVEF, and the relief of HF symptoms.
In conclusion, CRT-D with MPP is very useful in improving the LVEF of the patient with ischemic cardiomyopathy and HFrEF. And the resolution of fQRS may be a sign of the alleviation of HFrEF by using CRT-D with MPP.
#Fragmented QRS#Heart failure#Cardiac resynchronization therapy#Multipoint pacing#Journal of Clinical Case Reports Medical Images and Health Sciences#jcrmhs
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Who Is Eligible for a Fellowship in Critical Care?
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A fellowship in critical care medicine is a specialized training program designed for healthcare professionals aiming to become experts in managing critically ill patients. This advanced training focuses on diagnosing, monitoring, and treating life-threatening conditions that require intensive care. But who is eligible for a critical care fellowship? Let’s explore the requirements and pathways.
What Is a Critical Care Fellowship?
A critical care fellowship equips physicians with the skills needed to handle complex medical emergencies, including multi-organ failure, sepsis, trauma, and post-operative care. Fellowships are typically offered in disciplines such as internal medicine, anesthesia, surgery, or emergency medicine, with training often spanning 1-2 years.
General Eligibility Criteria for a Critical Care Fellowship
To qualify for a critical care fellowship, candidates must meet specific educational and professional prerequisites, which can vary depending on the country and institution. However, the general requirements include:
1. Completion of a Medical Degree
Candidates must hold a recognized medical degree (MD, DO, MBBS, or equivalent).
Graduates from international medical schools may need to pass qualifying exams like the USMLE (United States) or PLAB (UK) to demonstrate eligibility.
2. Residency Training
Fellowship applicants must complete a residency program in a related specialty. Common pathways include:
Internal Medicine: Often followed by a pulmonary-critical care combined fellowship.
Anesthesiology: A route for those focusing on perioperative and critical care management.
Emergency Medicine: Ideal for physicians managing acute, life-threatening emergencies.
Surgery: Specialized critical care fellowships cater to post-surgical intensive care.
3. Board Certification (or Eligibility)
Most programs require candidates to be board-certified or board-eligible in their primary specialty. This ensures a foundational knowledge base and clinical expertise.
4. Licensing Requirements
A valid medical license to practice in the country or state where the fellowship is offered is typically mandatory.
5. Other Selection Criteria
Strong letters of recommendation from mentors or program directors.
Evidence of clinical experience, research, or academic achievements in critical care-related areas.
A personal statement highlighting the candidate's motivation, career goals, and commitment to the specialty.
Specialized Tracks and Subspecialties
Critical care fellowships are diverse and may focus on specific patient populations or medical conditions. Examples include:
Neurocritical Care: Specializing in critically ill neurological and neurosurgical patients.
Pediatric Critical Care: Focused on the intensive care of children.
Cardiothoracic Critical Care: For managing post-cardiac surgery patients or severe cardiac conditions.
Trauma Critical Care: Designed for surgeons or emergency medicine physicians focusing on trauma-related emergencies.
Application Process
The application process typically includes submitting credentials, passing interviews, and ranking programs through matching services like the National Resident Matching Program (NRMP) for U.S.-based fellowships. International candidates may also need visas and additional qualifications.
Why Pursue a Critical Care Fellowship?
The demand for skilled intensivists is growing globally, making this a rewarding career choice for physicians passionate about saving lives in high-stakes environments. Critical care fellows gain access to advanced training, cutting-edge technology, and opportunities to contribute to research and education.
Conclusion
Eligibility for a fellowship in critical care depends on a strong foundation in medicine, completion of relevant residency training, and a passion for managing critically ill patients. By meeting these criteria and demonstrating a commitment to excellence, aspiring intensivists can embark on a fulfilling career in one of the most dynamic fields of medicine.
For specific details, consult the program guidelines of the institution or region where you wish to apply.
#delhi#india#medical courses#health#healthcare#health and wellness#health & fitness#healthyliving#healthylifestyle
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Pneumonia Specialists in Hyderabad: Expert Care for Your Respiratory Health
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Pneumonia is a serious respiratory condition that affects millions of people each year. It occurs when the air sacs in the lungs become inflamed, often due to an infection. Pneumonia can cause severe breathing difficulties, fever, and fatigue, and in some cases, it can be life-threatening. Early diagnosis and treatment are crucial for managing pneumonia effectively and preventing complications.
If you or a loved one is suffering from pneumonia or showing symptoms such as persistent cough, chest pain, shortness of breath, or fever, seeking the help of a qualified pneumonia specialist is essential. Hyderabad is home to several top pulmonologists and pneumonia specialists who provide expert care and ensure that patients receive the best treatment options.
At TX Hospitals, we have a team of experienced specialists who are highly skilled in diagnosing and treating pneumonia. Our pulmonologists use advanced diagnostic tools and treatment protocols to offer personalized care for every patient.
1. Dr. Sathish Pogula – Experienced Pneumonia Specialist
Dr. Sathish Pogula is a highly respected chest and pneumonia specialist in Hyderabad. With an MBBS, MD, and IDCCM qualification, Dr. Pogula has extensive experience in treating respiratory conditions, including pneumonia. His expertise in critical care medicine allows him to handle even the most severe cases of pneumonia, ensuring that patients receive timely and effective treatment.
Dr. Pogula uses advanced diagnostic methods such as chest X-rays, CT scans, and blood tests to determine the exact cause of pneumonia and create a tailored treatment plan. Whether it's bacterial, viral, or fungal pneumonia, Dr. Pogula ensures that every patient receives the right medication and support to recover swiftly.
2. Dr. Naresh Dude – Renowned Pulmonologist and Pneumonia Expert
Dr. Naresh Dude, with his MBBS, DNB, and FCCM certifications, is one of the leading pulmonologists in Hyderabad. Specializing in pulmonary medicine and critical care, Dr. Dude has vast experience in diagnosing and treating pneumonia, especially in severe or complicated cases. His thorough approach to patient care and his use of the latest medical technology ensure that patients receive the best possible outcomes.
Dr. Dude’s expertise in managing pneumonia in high-risk patients, such as the elderly, immunocompromised individuals, and those with chronic conditions, makes him one of the top choices for pneumonia treatment in Hyderabad. His compassionate care and dedication to improving his patients' quality of life have earned him a stellar reputation.
3. Dr. Rohith Reddy – Pulmonary Medicine Specialist
Dr. Rohith Reddy, an MBBS graduate with an MD in Pulmonary Medicine, is known for his expertise in treating various respiratory conditions, including pneumonia. Dr. Reddy takes a holistic approach to patient care, addressing not only the pneumonia itself but also the underlying conditions that may contribute to its development, such as asthma, COPD, or heart disease.
His patient-centered approach ensures that treatment plans are customized to each patient’s unique needs, helping them recover quickly and prevent future respiratory infections. Dr. Reddy's vast experience and knowledge make him one of the top pneumonia specialists in Hyderabad.
4. Dr. M.V. Sree Keerthi – Specialist in Pulmonary and Respiratory Care
Dr. M.V. Sree Keerthi is a highly skilled pulmonologist specializing in treating pneumonia and other respiratory conditions. With an MBBS, DNB, and DTCD in Pulmonary Medicine, Dr. Keerthi has extensive training in managing both uncomplicated and complex pneumonia cases.
Dr. Keerthi uses a combination of medical interventions, including antibiotics, antivirals, and antifungals, as well as respiratory therapies, to treat pneumonia. She is also skilled in managing pneumonia-related complications such as respiratory failure or pleural effusion, ensuring comprehensive care for her patients.
Why Choose TX Hospitals for Pneumonia Treatment?
TX Hospitals is equipped with state-of-the-art facilities and a team of highly skilled pneumonia specialists who offer advanced care for patients suffering from respiratory conditions. Our hospital offers a wide range of diagnostic tools, including digital X-rays, CT scans, and pulmonary function tests, to accurately diagnose pneumonia and determine its cause.
Services at TX Hospitals:
Comprehensive Pneumonia Diagnosis: We offer advanced diagnostic tests, such as blood tests, chest X-rays, and sputum cultures, to identify the type and cause of pneumonia.
Personalized Treatment Plans: Based on the diagnosis, our specialists create customized treatment plans, including antibiotics, antivirals, and antifungals, along with respiratory support if necessary.
Critical Care: For severe cases of pneumonia, we offer intensive care services, including mechanical ventilation and monitoring, to support respiratory function.
Pulmonary Rehabilitation: We provide rehabilitation programs to help patients recover and regain their lung function after an illness like pneumonia.
Book an Appointment Today
If you or a loved one is suffering from pneumonia, don't wait for symptoms to worsen. Book an appointment with one of our expert pneumonia specialists at TX Hospitals today. Our team is committed to providing timely, effective, and compassionate care to help you recover quickly.
For appointments, call 9089 48 9089. Our team at TX Hospitals is here to help you breathe easier and get back to a healthy, active life.
At TX Hospitals, we are committed to providing the highest quality care for all respiratory conditions, including pneumonia. With our experienced specialists and advanced treatment options, we ensure that every patient receives the care they need for a full recovery.
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