#J147 curcumin

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J147 Powder Benefits: A Potent Curcumin Derivative丨wisepowder

What Is J147 Powder?

J147 powder is different to the common seen nootropics powder for Alzheimer's disease,J147 powder is neither an acetylcholinesterase inhibitor nor a phosphodiesterase inhibitor, yet it enhances cognition with a short-term treatment.

 J147 Vs Curcumin

J147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. What is the difference between J147 and Curcumin?

 J147 (CAD-031) is a Curcumin and Cyclohexyl-Bisphenol A (CBA) derivative that is a potent neurogenic and neuroprotective drug.

It was developed for the use of treating neurodegenerative conditions associated with aging.

 Curcumin is a polyphenol and the active component of Turmeric and Ginger. Curcumin has many proven benefits in treating numerous diseases, but due to its poor ability to cross the Blood-Brain Barrier (BB), there are clear limitations.

 J147 can cross the BBB into the brain (strong) and induce neuronal stem cell production.

 J147 Benefits

The benefits of J147 may include:

 1) Improves Mitochondrial Function And Longevity

2) Prevents Alzheimer's Disease

3) Improves Memory

4) Grows The Brain

5) Protects Neurons

6) May Improve Diabetes

7) Fights Pain And Neuropathy

8) May Improve Anxiety

 Buy J147 Powder online

 Many nootropics powder supplier sell J147 under the nootropic catalog, In order to gain the benefits of J147, you can buy J147 powder from the trustworthy nootropics powder factory. They can provide the testing reports of the goods.

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J-147

J-147

N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N’-[(E)-(3-methoxyphenyl)methylene]acetohydrazide

Molecular FormulaC18H17F3N2O2

Average mass350.335 Da

2,2,2-trifluoroacetic acid-1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide

Acetic acid, 2,2,2-trifluoro-, 1-(2,4-dimethylphenyl)-2-[(1E)-(3-methoxyphenyl)methylene]hydrazide

N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N’-[(E)-(3-methoxyph…

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What is Raw J-147 powder (1146963-51-0)?

https://www.phcoker.com/product/1146963-51-0/

J-147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging.It is a curcumin derivative and a potent neurogenic and neuroprotective drug candidate initially developed for the treatment of neurodegenerative conditions associated with aging that impacts many pathways implicated in the pathogenesis of diabetic neuropathy.

J-147 almost ready for clinical trials in humans. Now, Salk scientists have solved the puzzle of what, exactly, J147 does. In a paper published January 7, 2018, in the journal Aging Cell, they report that the drug binds to a protein found in mitochondria, the energy-generating powerhouses of cells. In turn, they showed, it makes aging cells, mice and flies appear more youthful....

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Experimental Drug J147(1146963-51-0) Alzheimer’s Aging http://www.aasraw.com/experimental-drug-j147-alzheimers-aging/ http://www.aasraw.com/products/j-147-powder/ Alzheimer’s disease research has attracted some of the most brilliant minds in medical research over the past 20 years. While researchers have learned a lot about the diseases, its pathology, and its triggers, relatively little progress has been in made on fighting the disease. The team behind experimental drug J147 (1146963-51-0) decided to take a different approach. The early results have been impressive, and researchers are continuing to study how this new drug interacts with the different cells of the body. What is J147? J147 is a nootropics powder first developed in 2011. Researchers have found that the drug, across several different studies, can reverse memory loss and slow, or even reverse, Alzheimer’s in mice. J147 powder is a phenyl hydrazide. It is derived from the curry spice component curcumin. It is a low toxicity. Despite some early concerns, J147 powder has not been shown to be carcinogenic. Researchers tested extensively for this possibility by examining the metabolites of J147 in human and mouse microsomes and mouse plasma. The results showed that J147 is not metabolized to aromatic amines or hydrazines. #J147#J147powder#1146963510#Alzheimer#nootropicspowder#J147bebefits#J147dosage#J147sideeffects#J147powdersupplier#J147powderlab#

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Alzheimer’s drug turns back clock in powerhouse of cell

The experimental drug J147 is something of a modern elixir of life; it's been shown to treat Alzheimer's disease and reverse aging in mice and is almost ready for clinical trials in humans. Now, Salk scientists have solved the puzzle of what, exactly, J147 does. In a paper published January 7, 2018, in the journal Aging Cell, they report that the drug binds to a protein found in mitochondria, the energy-generating powerhouses of cells. In turn, they showed, it makes aging cells, mice and flies appear more youthful.

"This really glues together everything we know about J147 in terms of the link between aging and Alzheimer's," says Dave Schubert, head of Salk's Cellular Neurobiology Laboratory and the senior author on the new paper. "Finding the target of J147 was also absolutely critical in terms of moving forward with clinical trials."

Schubert's group developed J147 in 2011, after screening for compounds from plants with an ability to reverse the cellular and molecular signs of aging in the brain. J147 is a modified version of a molecule found in the curry spice curcumin. In the years since, the researchers have shown that the compound reverses memory deficits, potentiates the production of new brain cells, and slows or reverses Alzheimer's progression in mice. However, they didn't know how J147 worked at the molecular level.

In the new work, led by Schubert and Salk Research Associate Josh Goldberg, the team used several approaches to home in on what J147 is doing. They identified the molecular target of J147 as a mitochondrial protein called ATP synthase that helps generate ATP-the cell's energy currency-within mitochondria. They showed that by manipulating its activity, they could protect neuronal cells from multiple toxicities associated with the aging brain. Moreover, ATP synthase has already been shown to control aging in C. elegans worms and flies.

"We know that age is the single greatest contributing factor to Alzheimer's, so it is not surprising that we found a drug target that's also been implicated in aging," says Goldberg, the paper's first author.

Further experiments revealed that modulating activity of ATP synthase with J147 changes the levels of a number of other molecules-including levels of ATP itself-and leads to healthier, more stable mitochondria throughout aging and in disease.

"I was very surprised when we started doing experiments with how big of an effect we saw," says Schubert. "We can give this to old mice and it really elicits profound changes to make these mice look younger at a cellular and molecular level."

The results, the researchers say, are not only encouraging for moving the drug forward as an Alzheimer's treatment, but also suggest that J147 may be useful in other age-associated diseases as well.

"People have always thought that you need separate drugs for Alzheimer's, Parkinson's and stroke" says Schubert. "But it may be that by targeting aging we can treat or slow down many pathological conditions that are old-age-associated."

The team is already performing additional studies on the molecules that are altered by J147's effect on the mitochondrial ATP synthase-which could themselves be new drug targets. J147 has completed the FDA-required toxicology testing in animals, and funds are being sought to initiate phase 1 clinical trials in humans.

Other researchers on the study were A. Currais, M. Prior, W. Fischer, C. Chiruta, D. Daugherty, R. Dargusch and P. Maher of the Salk Institute; E. Ratliff and K. Finley of San Diego State University; P.B. Esparza-Molto and J.M. Cuezva of the Universidad Autonoma de Madrid; and M. Petrascheck of The Scripps Research Institute.

The work and the researchers involved were supported by grants from the National Institutes of Health, California Institute of Regenerative Medicine, the Nomis Foundation, the Della Thome Foundation, the Bundy Foundation, the Hewitt Foundation, the Paul F. Glenn Center for Aging Research at the Salk Institute and the Waitt Foundation.

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Experimental Drug J147(1146963-51-0) Alzheimer’s Aging

Alzheimer’s disease research has attracted some of the most brilliant minds in medical research over the past 20 years. While researchers have learned a lot about the diseases, its pathology, and its triggers, relatively little progress has been in made on fighting the disease.

The team behind experimental drug J147 (1146963-51-0) decided to take a different approach. The early results have been impressive, and researchers are continuing to study how this new drug interacts with the different cells of the body.

What is J147?

J147 is a nootropics powder first developed in 2011. Researchers have found that the drug, across several different studies, can reverse memory loss and slow, or even reverse, Alzheimer’s in mice.

J147 powder is a phenyl hydrazide. It is derived from the curry spice component curcumin. It is a low toxicity. Despite some early concerns, J147 powder has not been shown to be carcinogenic. Researchers tested extensively for this possibility by examining the metabolites of J147 in human and mouse microsomes and mouse plasma.

The results showed that J147 is not metabolized to aromatic amines or hydrazines.

Traditional Approaches to Fighting Alzheimer’s

Most drugs developed in the past 20 years have been targeted on the amyloid plaque deposits in the brains of Alzheimer’s patients. This approach makes intuitive sense because these deposits are what choke the nerve cells to death.

However, after 20 years there has not been any significant progress in clinical trials with any of the drugs that target the plaque deposits.

A related approach has been to try and target the amyloid before it forms the plaque deposits. The amyloid destroys synapses before it forms into plaque clumps. However, even this earlier targeting has not proven to be effective.

Until the development of J147 (1146963-51-0), the actual treatment of Alzheimer’s was at a standstill. There wasn’t any clear path forward with any of the drugs that had been developed over the past 20 years and the pathology of the disease itself did not lend itself to any other obvious approaches.

How J147 (1146963-51-0) Works Against Alzheimer’s

The team behind J147 decided to take a different tact in the fight against Alzheimer’s. Instead of developing yet another drug that targeted amyloid, the team decided to focus on a major risk factor for Alzheimer’s. The biggest single risk factor is old age—so the team turned its efforts to anti-aging mechanisms.

The team created J147 by using cell-based screens against old-age brain toxicities. From these screens, they synthesized the J147 powder.

The J147 powder works by reducing the activity of the ATP synthase in the mitochondria. This protected neuronal cells from many of the age-related brain toxicities. Research indicated the reason this compound produces this neuroprotective effect is because of the role excitotoxicity plays in neuronal cell damage.

Neurons become damaged and are killed by the overactivation of the receptors for the excitatory neurotransmitter glutamate. J147 essentially slows down the processes that certain old-age brain toxicities speed up. This preserves the neurons and, even more remarkably, can also trigger the reversal of some of the more pronounced effects of Alzheimer’s.

J147 Works as an Anti-Aging Agent

The mechanics of J147 are nothing like the other Alzheimer’s drugs that have reached a similar stage of research. Because it doesn’t focus on the traditional pathology of the disease, but rather works to mitigate the dangers presented by the aging risk factor.

J147 works as an anti-aging agent. Left to its own devices, the human brain develops certain toxicities. It is these age-related toxicities that create the environment for Alzheimer’s to flourish. J147 turns back the clock on these toxicities, in turn this makes it harder for Alzheimer’s to do its work of deteriorating different memory systems.

It is probable that the approach pioneered by J147 will be useful for far more than just the fight against Alzheimer’s. Similar anti-aging agents may be able to target other toxicities that cause other diseases and ailments where age alone is a primary risk factor. J147 is not just an Alzheimer’s drug. It is really a drug that helps reverse aging itself.

J147 Clinical Trials

Even though J147 was first developed in 2011, it just now nearing approval for widespread clinical trials. At every step along the way, J147 has been shown to not only be incredibly effective, but it has also been shown to be stable.

Early concerns about the possibility of J147 being carcinogenic, or otherwise toxic, have been shown to be unfounded.

Researchers are anxious to get the clinical trials underway and almost everyone involved in Alzheimer’s research is hopeful that J147 will prove to be as effective in humans as it has been in mice and in laboratory simulations.

Preliminary J147 Findings

Early on researchers found that J147 (1146963-51-0) could prevent, and reverse, memory loss in mice that have the inherited version of Alzheimer’s. However, as hopeful as that result was, in humans, only about 1% of Alzheimer’s patients have the inherited version. The most common form of Alzheimer’s is associated not with a specific set of genetics, but with old age itself.

The team than studied the effects of J147 on a group of mice that age rapidly and experience a form of dementia that is similar to the age-related Alzheimer’s found in humans.

The results of this second study were also promising. J147 was able to rescue cognitive deficits, even when administered in the late stages of the disease. It improved memory in the mice and prevented further deterioration.

It was also found that when J147 was combined with donepezil it worked better for restoring contextual and cued memory. But, J147 alone was superior in restoring spatial memory.

What the Future Holds for J147 (1146963-51-0)

There is still a long road before J147 (1146963-51-0) will be available to treat most Alzheimer’s patients. First the drug must complete the rigorous clinical trial phase. Once the clinical trials have been peer reviewed, the process for FDA approval will begin.

Researchers are mindful of the urgent need for a meaningful treatment for Alzheimer’s disease, but they are also committed to not rushing the science. So far, all of the results for J147 are extremely positive and no other Alzheimer’s drug has ever looked this good this far into the process.

More about J147:

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1.To contact us by our email inquiry system,or online skypecustomer service representative(CSR). Whatsapp/ Skype: +13204079052

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Promising Alzheimer�s Drug Nearing Clinical Trials

J147

J147, the molecular concentrating on drug, has long been demonstrated to deal with Alzheimer�s condition and reverse getting older in mice is nearing readiness for the medical trials in human beings. Scientists have already been in a position to determine what precisely J147 does,reporting that the drug binds to your protein uncovered in the mitochondria that is the electricity generating powerhouse in the cells, demonstrating that it makes the all over again cells, mice and flies seem younger as posted while in the journal Growing old Cell.

j147 buy

J147, the molecular targeting drug, has long been proven to deal with Alzheimer�s ailment and reverse getting older in mice is nearing readiness with the scientific trials in individuals. Scientists happen to be able to ascertain what exactly J147 does,reporting the drug binds into a protein located within the mitochondria which happens to be the electrical power producing powerhouse with the cells, showing that it makes the once more cells, mice and flies surface more youthful as revealed within the journal Growing old Cell.

Getting the concentrate on of J147 was key in being able to transfer ahead to clinical trials. J147 was formulated in 2011 soon after screening for compounds from plants that will hold the skill to reverse the molecular and mobile signs of getting old from the brain, it can be a modified variation of the molecule located within just the curry spice curcumin, it's been demonstrated to reverse memory problems, potentiates manufacture of new brain cells, and also to gradual the progression of Alzheimer�s in mice.

A mitochondrial protein named ATP synthase has been discovered since the molecular goal of J147 that assists to generate ATP which is the cell�s electricity currency inside of the mitochondria. It had been revealed that by manipulating its action guarded the neuronal cells from several toxicities which are associated while using the growing old brain. ATP synthase has formerly been revealed to get the ability to control aging in flies and C. elegans worms.

More reports performed confirmed that modulating the activity of ATP synthase in just J147 variations the amounts of several other molecules which include levels of ATP itself leading to a far more stable and much healthier mitochondria through illness and aging. The effects are promising for not just shifting forward with a therapy for Alzheimer�s and also as feasible treatment plans in other age related illnesses too as it might be that concentrating on ageing can also handle or sluggish down pathological situations which might be age related.

J147 has handed Food and drug administration essential toxicology tests in animals, funding is now remaining sought after to begin period 1 of human clinical trials.

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Alzheimer's drug J147: A Potent Curcumin Derivative J147 neurotrophic compound

Alzheimer’s drug J147: A Potent Curcumin Derivative J147 neurotrophic compound

Alzheimer's drug J147: A Potent Curcumin Derivative J147 Neurotrophic Compound 

  1. What Is J147?

Alzheimer's drugJ147(1146963-51-0), is a potent neuroprotective and neurotrophic compound. J147 protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 – 200 nM). J147. J147 reverses cognitive impairment in aged Alzheimer's disease mice. J147 is an exciting new compound that is…

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Alzheimer's drug J147 powder: What is J147 made from?

Alzheimer's drug J147 powder is something of a modern elixir of life; J147 alzheimer drug been shown to treat Alzheimer’s disease and reverse aging in mice and is almost ready for J147 clinical trials in humans.

What is J147 made from? Compound J147 is a neuroprotective and neurotrophic compound which is developed by Schubert's  group in 2011.Compound J147 drug buy is a modifid version of a molecule(curcumin) found in the curry spice turmeric.Under the correct J147 dosage, the researchers have shown that the compound J147 reverses memory deficits, potentiates the production of new brain cells, and slows or reverses Alzheimer’s progression in mice.In the market, J147 for sale is powder type.

https://www.wisepowder.com/product-details/1146963-51-0/

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J147 Powder Benefits: A Potent Curcumin Derivative丨wisepowder nootropics...

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Experimental Drug J147(1146963-51-0) Alzheimer’s Aging http://www.aasraw.com/experimental-drug-j147-alzheimers-aging/ http://www.aasraw.com/products/j-147-powder/ Alzheimer’s disease research has attracted some of the most brilliant minds in medical research over the past 20 years. While researchers have learned a lot about the diseases, its pathology, and its triggers, relatively little progress has been in made on fighting the disease. The team behind experimental drug J147 (1146963-51-0) decided to take a different approach. The early results have been impressive, and researchers are continuing to study how this new drug interacts with the different cells of the body. What is J147? J147 is a nootropics powder first developed in 2011. Researchers have found that the drug, across several different studies, can reverse memory loss and slow, or even reverse, Alzheimer’s in mice. J147 powder is a phenyl hydrazide. It is derived from the curry spice component curcumin. It is a low toxicity. Despite some early concerns, J147 powder has not been shown to be carcinogenic. Researchers tested extensively for this possibility by examining the metabolites of J147 in human and mouse microsomes and mouse plasma. The results showed that J147 is not metabolized to aromatic amines or hydrazines. #J147#J147powder#1146963510#Alzheimer#nootropicspowder#J147bebefits#J147dosage#J147sideeffects#J147powdersupplier#J147powderlab#

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Experimental Drug J147(1146963-51-0) Alzheimer’s Aging http://www.aasraw.com/experimental-drug-j147-alzheimers-aging/ http://www.aasraw.com/products/j-147-powder/ Alzheimer’s disease research has attracted some of the most brilliant minds in medical research over the past 20 years. While researchers have learned a lot about the diseases, its pathology, and its triggers, relatively little progress has been in made on fighting the disease. The team behind experimental drug J147 (1146963-51-0) decided to take a different approach. The early results have been impressive, and researchers are continuing to study how this new drug interacts with the different cells of the body. What is J147? J147 is a nootropics powder first developed in 2011. Researchers have found that the drug, across several different studies, can reverse memory loss and slow, or even reverse, Alzheimer’s in mice. J147 powder is a phenyl hydrazide. It is derived from the curry spice component curcumin. It is a low toxicity. Despite some early concerns, J147 powder has not been shown to be carcinogenic. Researchers tested extensively for this possibility by examining the metabolites of J147 in human and mouse microsomes and mouse plasma. The results showed that J147 is not metabolized to aromatic amines or hydrazines. #J147#J147powder#1146963510#Alzheimer#nootropicspowder#J147bebefits#J147dosage#J147sideeffects#J147powdersupplier#J147powderlab#

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Experimental Drug J147(1146963-51-0) Alzheimer’s Aging http://www.aasraw.com/experimental-drug-j147-alzheimers-aging/ http://www.aasraw.com/products/j-147-powder/ Alzheimer’s disease research has attracted some of the most brilliant minds in medical research over the past 20 years. While researchers have learned a lot about the diseases, its pathology, and its triggers, relatively little progress has been in made on fighting the disease. The team behind experimental drug J147 (1146963-51-0) decided to take a different approach. The early results have been impressive, and researchers are continuing to study how this new drug interacts with the different cells of the body. What is J147? J147 is a nootropics powder first developed in 2011. Researchers have found that the drug, across several different studies, can reverse memory loss and slow, or even reverse, Alzheimer’s in mice. J147 powder is a phenyl hydrazide. It is derived from the curry spice component curcumin. It is a low toxicity. Despite some early concerns, J147 powder has not been shown to be carcinogenic. Researchers tested extensively for this possibility by examining the metabolites of J147 in human and mouse microsomes and mouse plasma. The results showed that J147 is not metabolized to aromatic amines or hydrazines. #J147#J147powder#1146963510#Alzheimer#nootropicspowder#J147bebefits#J147dosage#J147sideeffects#J147powdersupplier#J147powderlab#

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Experimental Drug J147(1146963-51-0) Alzheimer’s Aging http://www.aasraw.com/experimental-drug-j147-alzheimers-aging/ http://www.aasraw.com/products/j-147-powder/ Alzheimer’s disease research has attracted some of the most brilliant minds in medical research over the past 20 years. While researchers have learned a lot about the diseases, its pathology, and its triggers, relatively little progress has been in made on fighting the disease. The team behind experimental drug J147 (1146963-51-0) decided to take a different approach. The early results have been impressive, and researchers are continuing to study how this new drug interacts with the different cells of the body. What is J147? J147 is a nootropics powder first developed in 2011. Researchers have found that the drug, across several different studies, can reverse memory loss and slow, or even reverse, Alzheimer’s in mice. J147 powder is a phenyl hydrazide. It is derived from the curry spice component curcumin. It is a low toxicity. Despite some early concerns, J147 powder has not been shown to be carcinogenic. Researchers tested extensively for this possibility by examining the metabolites of J147 in human and mouse microsomes and mouse plasma. The results showed that J147 is not metabolized to aromatic amines or hydrazines. #J147#J147powder#1146963510#Alzheimer#nootropicspowder#J147bebefits#J147dosage#J147sideeffects#J147powdersupplier#J147powderlab#

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Experimental Drug J147(1146963-51-0) Alzheimer’s Aging http://www.aasraw.com/experimental-drug-j147-alzheimers-aging/ http://www.aasraw.com/products/j-147-powder/ Alzheimer’s disease research has attracted some of the most brilliant minds in medical research over the past 20 years. While researchers have learned a lot about the diseases, its pathology, and its triggers, relatively little progress has been in made on fighting the disease. The team behind experimental drug J147 (1146963-51-0) decided to take a different approach. The early results have been impressive, and researchers are continuing to study how this new drug interacts with the different cells of the body. What is J147? J147 is a nootropics powder first developed in 2011. Researchers have found that the drug, across several different studies, can reverse memory loss and slow, or even reverse, Alzheimer’s in mice. J147 powder is a phenyl hydrazide. It is derived from the curry spice component curcumin. It is a low toxicity. Despite some early concerns, J147 powder has not been shown to be carcinogenic. Researchers tested extensively for this possibility by examining the metabolites of J147 in human and mouse microsomes and mouse plasma. The results showed that J147 is not metabolized to aromatic amines or hydrazines. #J147#J147powder#1146963510#Alzheimer#nootropicspowder#J147bebefits#J147dosage#J147sideeffects#J147powdersupplier#J147powderlab#

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Experimental Drug J147(1146963-51-0) Alzheimer’s Aging http://www.aasraw.com/experimental-drug-j147-alzheimers-aging/ http://www.aasraw.com/products/j-147-powder/ Alzheimer’s disease research has attracted some of the most brilliant minds in medical research over the past 20 years. While researchers have learned a lot about the diseases, its pathology, and its triggers, relatively little progress has been in made on fighting the disease. The team behind experimental drug J147 (1146963-51-0) decided to take a different approach. The early results have been impressive, and researchers are continuing to study how this new drug interacts with the different cells of the body. What is J147? J147 is a nootropics powder first developed in 2011. Researchers have found that the drug, across several different studies, can reverse memory loss and slow, or even reverse, Alzheimer’s in mice. J147 powder is a phenyl hydrazide. It is derived from the curry spice component curcumin. It is a low toxicity. Despite some early concerns, J147 powder has not been shown to be carcinogenic. Researchers tested extensively for this possibility by examining the metabolites of J147 in human and mouse microsomes and mouse plasma. The results showed that J147 is not metabolized to aromatic amines or hydrazines. #J147#J147powder#1146963510#Alzheimer#nootropicspowder#J147bebefits#J147dosage#J147sideeffects#J147powdersupplier#J147powderlab#