#Ibrutinib Capsules

[thelotusbiotech]

Ibrunat 140mg is a medication containing the active salt Ibrutinib, designed to treat various B-cell cancers, such as chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Ibrutinib works by inhibiting specific enzymes that promote cancer cell growth.

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[melonglobalcare]

Mantle-Cell Lymphoma: A Comprehensive Guide to Managing the Disease

Mantle-Cell Lymphoma is a rare type of cancer that affects the lymphatic system. The lymphatic system is a network of tissues and organs that help your body fight infections and diseases. MCL develops when abnormal B cells (a type of white blood cell) grow out of control and form tumors in the lymph nodes. MCL is considered an aggressive type of lymphoma, which means it can grow and spread quickly to other parts of the body, such as the bone marrow, spleen, and digestive tract.

Symptoms of MCL may include swollen lymph nodes, fatigue, weight loss, night sweats, and stomach pain. However, these symptoms are not specific to MCL and can be caused by other conditions. Therefore, a proper diagnosis is crucial for determining the appropriate treatment plan.

How is Mantle-Cell Lymphoma Diagnosed?

MCL is diagnosed through a combination of tests and procedures. The first step is usually a physical examination, during which the doctor will check for swollen lymph nodes and other signs of MCL. Next, the doctor may order blood tests to check for abnormal levels of certain proteins and other substances that may indicate the presence of MCL. A biopsy may also be performed, which involves removing a sample of tissue from the lymph node and examining it under a microscope to look for cancer cells.

In some cases, additional tests may be necessary to determine the stage of MCL. This may include imaging tests, such as CT scans or PET scans, which can show whether the cancer has spread to other parts of the body. Once the diagnosis and stage of MCL have been determined, the doctor can develop a treatment plan.

Coping with Mantle-Cell Lymphoma

Coping with MCL can be challenging, both physically and emotionally. However, there are several strategies that can help patients manage their symptoms and improve their quality of life.

Mantle-Cell Lymphoma Support Groups

Joining a support group can be a helpful way for patients with MCL to connect with others who are going through similar experiences. Support groups can provide emotional support, information about treatment options, and practical advice for managing symptoms.

Mind-Body Techniques

Mind-body techniques, such as meditation, yoga, and tai chi, can help patients manage stress and anxiety associated with MCL. These techniques can also improve physical symptoms, such as fatigue and pain.

Treatment Options for Mantle-Cell Lymphoma

The treatment plan for MCL will depend on several factors, including the stage of the cancer, the patient’s age and overall health, and the patient’s preferences. The goals of treatment for MCL are to eliminate cancer cells, relieve symptoms, and prevent the cancer from returning. There are several treatment options available for MCL, including chemotherapy, radiation therapy, stem cell transplant, and clinical trials. In some cases, a combination of these treatments may be used.

It can also be treated by medicines. You can buy the medicine online. Nitib 140mg Capsule is used to treat Mantle-Cell Lymphoma and chronic lymphocytic leukemia. It contains Ibrutinib (140mg). This medicine is supplied online by Melon GlobalCare. Melon GlobalCare is a well-established healthcare brand and one of the world’s upcoming distributors in the pharmaceutical industry. They offer the finest Medical Facilities and provide the highest quality medications at reasonable prices.

[mediwinpharma]

Top Demand Drug companies in India in the Last Decade

Over the past decade, the demand for drug companies in India has significantly increased, reflecting the country's evolving healthcare industry. In fact, a report by Statista indicates that the Indian healthcare and pharmaceuticals sector is anticipated to experience an extraordinary growth rate of 754% between 2017 and 2060.

As India emerges as a major player in the pharmaceutical industry, it is critical to understand the demand for various drugs in the country. It provides valuable insights into the health concerns of the people, the shifting demographics, and the evolving medical requirements.

So, read the article below to gain in-depth knowledge about high-demand drugs in India and the factors influencing this demand. This knowledge can help drug companies to focus their R&D and production to cater to the specific needs of the Indian market.

Top 8 Demand Drugs in India

Some of the best drugs in India and their uses are given below:

1. Humira

Humira (adalimumab) is a widely used biological medication known for its effectiveness in treating various conditions. It functions as a tumor necrosis blocker, which helps suppress the immune system by blocking the activity of factor-α (TNF). TNF is a protein associated with inflammation and autoimmune diseases.

Uses

Treats rheumatoid arthritis in adults.

Indicated for adults with hidradenitis suppurativa (HS).

Tackles chronic plaque psoriasis.

Treats non-infectious intermediate, posterior, and panuveitis.

Approved for adult patients with active ulcerative colitis.

Used to reduce signs and symptoms of active ankylosing spondylitis.

2. Keytruda

Keytruda is a cancer medication that contains the active substance pembrolizumab. It belongs to a class of drugs known as immune checkpoint inhibitors. Keytruda blocks a protein called PD-1 in immune cells. This allows the immune system to recognize and attack cancer cells.

Uses

Treats advanced or metastatic melanoma.

Treats advanced NSCLC.

Treats children with classical Hodgkin lymphoma.

Treats advanced renal cell carcinoma.

Used in combination with chemotherapy or other cancer medicines to treat oesophageal cancer.

Prevents blood clots in cases like broken bones, immobility, surgeries, etc.

3. Eliquis

Eliquis is a prescription medication that belongs to the class of drugs known as anticoagulants or blood thinners. It is considered an anticoagulant because apixaban is its active ingredient. Eliquis is FDA-approved for treating and preventing dangerous blood clots that can block blood vessels in the body.

Uses

Treats deep vein thrombosis (DVT).

Prevents stroke.

Treats pulmonary embolism (PE).

Reduces the risk of systemic embolism.

Avoids thromboembolic events in individuals with chronic kidney disease.

Used as an anticoagulant therapy during cardiac catheterization procedures

4. Revlimid

Revlimid is a medication that contains the drug lenalidomide. It is a thalidomide analog, an immunomodulatory drug (IMiD) with various putative molecular targets and biological effects. Revlimid is primarily used to treat multiple types of cancers affecting blood cells.

Uses

Used in combination with dexamethasone for the treatment of multiple myeloma.

Used as maintenance therapy after an autologous hematopoietic stem cell transplant (auto-HSCT).

Treats lymphoplasmacytic lymphoma.

Used off-label for the treatment of systemic light-chain amyloidosis.

Tackles myelodysplastic syndromes.

Used in combination with rituximab to treat follicular and marginal zone lymphoma.

5. Imbruvica

Imbruvica is a medication available in tablet and capsule forms that are taken orally once a day. Its active ingredient is ibrutinib. Ibrutinib works by inhibiting specific proteins in cancer cells, slowing their growth, and preventing the spread of cancer.

Uses

Treats mantel cell lymphoma (MCL).

Treats chronic lymphocytic leukemia (CLL).

Tackles small lymphocytic lymphoma (SLL).

Treats waldenström's macroglobulinemia (WM).

Manages chronic graft versus host disease (cGVHD).

Prescribed off-label to diffuse large B-cell lymphoma (DLBCL).

6. Stelara

Stelara is a highly effective medication that contains ustekinumab. Ustekinumab is a monoclonal antibody derived from immune system cells. It is specifically designed to target and alleviate the symptoms of various inflammatory conditions associated with immune system dysfunction.

Uses

Provides relief for people suffering from this autoimmune skin condition.

Treats psoriatic arthritis for adults.

Deals with the challenges of moderate to severe Crohn's disease.

Treats adults with this type of inflammatory bowel disease.

Used off-label in the treatment of active systemic lupus erythematosus.

Used for investigational purposes of hidradenitis suppurativa.

7. Xarelto

Xarelto (rivaroxaban) is a medication also classified as a blood thinner. It works by inhibiting the activity of Factor Xa, an enzyme involved in blood clot formation. While Xarelto does not thin the blood, it helps prevent the formation of blood clots and reduces the risk of strokes and systemic embolisms in certain medical conditions.

Uses

Reduces the risk of stroke and systemic embolism with nonvalvular atrial fibrillation.

Treats and maintains drugs for deep vein thrombosis (DVT).

Reduces the risk of recurrence of pulmonary embolism.

Prevents blood clot formation in patients suffering from heart failure, respiratory disease, or infectious diseases.

Used as a prophylactic treatment to prevent blood clots in patients with cancer.

Prevents the recurrence of ischemic events, such as heart attacks or peripheral artery disease

8. Opdivo

Opdivo is an immunotherapy drug that belongs to a class of medications known as checkpoint inhibitors. It targets the PD-1 receptor, found on the surface of T cells, the immune cells responsible for fighting cancer. PD-1 helps regulate immune responses in healthy tissues, but cancer cells can exploit this mechanism to evade immune attacks. Opdivo blocks the interaction between PD-1 and PD-L1/PD-L2 molecules in cancer cells. This blockage enables T cells to recognize and destroy cancer cells effectively.

Uses

Treats advanced melanoma.

Treats non-small cell lung cancer.

Used in combination with ipilimumab for newly diagnosed malignant pleural mesothelioma.

Treats adult patients with classical Hodgkin lymphoma.

Treats patients with recurrent or metastatic head and neck squamous cell carcinoma.

Treats with microsatellite instability-high (MSI-H) or mismatch repair-deficient (dMMR) metastatic colon.

Factors that Impact the Demand for the Drugs

Here are four key factors that impact the demand for drugs:

1. Disease Prevalence and Epidemiology

The prevalence of diseases and their impact on the population greatly influence the demand for drugs. The burden of chronic diseases, or infectious outbreaks, shapes the market for specific medications to treat and manage these conditions.

2. Demographic Changes

Changing demographics, such as aging populations and urbanization, play a crucial role in drug demand. Different age groups have varying healthcare needs, and understanding demographic shifts helps target drug development and delivery strategies accordingly.

3. Economic Factors

Economic factors, including income levels, affordability, and healthcare expenditures, substantially impact drug demand. If medicines are expensive or not affordable, people may struggle to access their prescribed treatments. The cost and accessibility of medications greatly affect the choices people make and their ability to follow through with the necessary treatments.

4. Government Policies and Regulations

Regulatory frameworks, pricing regulations, reimbursement policies, and intellectual property rights all affect the availability, accessibility, and affordability of medicines. This further influences its demand in the market. Understanding and navigating these factors is crucial for ensuring that drugs are accessible and affordable to those who need them.

The Bottom Line

In conclusion, understanding the demand for drugs in India is vital for pharmaceutical companies, policymakers, and healthcare providers. By now, you must be aware of the factors that significantly impact drug demand. By aligning their strategies with these factors, stakeholders can meet the evolving healthcare needs of the Indian market effectively.

Moreover, if you're looking for a trusted name in the pharmaceutical industry for reliable and high-quality medications, consider Mediwin Pharmaceuticals. They have been one of the top pharma companies serving India since 1990. It is among the top pharmaceutical manufacturing companies in Ahmedabad because they facilitate effective medications for chronic conditions, specialized therapies, and preventive care.

So, visit Mediwin’s website today to discover its diverse product portfolio!

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[feodorgir78-blog]

Imbruvica (ibrutinib) cost in India and Where to buy

This medication is used to treat certain cancers (such as mantle cell or marginal zone lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, Waldenstrom's macroglobulinemia). Ibrutinib belongs to a class of drugs known as kinase inhibitors. It works by slowing or stopping the growth of cancer cells.

Ibrutinib 140 mg is also used to treat a certain problem that may occur after a stem cell transplant (chronic graft versus host disease). It works by weakening your body's defense system (immune system).

Read the Patient Information Leaflet if available from your pharmacist before you start taking ibrutinib and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with a full glass of water (8 ounces or 240 milliliters) as directed by your doctor, usually once daily. Swallow the capsules and tablets whole. Do not open, break, or chew the capsules. Do not cut, crush, or chew the tablets. Drink plenty of fluids while taking ibrutinib unless otherwise directed by your doctor.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). The cost of Imbruvica oral capsule 70 mg is around $13,546 for a supply of 28 capsules,

Do not increase your dose or take this medication more often than prescribed. Your condition will not improve any faster, and your risk of serious side effects will increase.

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Also avoid eating Seville oranges (often found in marmalade). Grapefruit and Seville oranges can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the capsules

Upset stomach, diarrhea, nausea, vomiting, decreased appetite, headache, joint/muscle pain, swelling of ankles/legs/feet, numbness/tingling of arms/legs, anxiety, constipation, dizziness, or tiredness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high. Your doctor may control your blood pressure with medication.

Tell your doctor right away if you have any serious side effects, including: easy bruising/bleeding, dark/tarry/bloody stools, fast/irregular/pounding heartbeat, signs of low red blood cell count (such as rapid breathing, pale skin, shortness of breath). You can easily to buy Ibrunat 140 mg price in india

[techminsolutions]

Zydus Cadila gets USFDA nod for cancer, high blood pressure treatment drug

Zydus Cadila gets USFDA nod for cancer, high blood pressure treatment drug

Drug firm Zydus Cadila on Thursday said it has received final approval from the US health regulator to market Ibrutinib Capsules, used to treat certain cancers. The company has also received nod to market Macitentan tablets, used to treat high blood pressure, in the American market. Zydus Cadila has received final approval from the US Food and Drug Administration (USFDA) to market Ibrutinib…

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Brand Name: Ibrukas Active Ingredients: Ibrutinib Capsules 140 mg Manufactured by: AprazerForm. Strength: 140 mg Sellar                                   https://www.jspharmaceuticals.com/ Form: Capsules Packing: Pack of 100 Capsules

Description: Ibrukast Ibrutinib Capsules 140 mg is an aimed therapy. It prevents the function of Bruton``s Tyrosine Kinase (BTK). Bruton``s Tyrosine Kinase is an important gesturing molecule of the B-cell receptor signaling complex that plays a significant role in the endurance of menacing B Cells. This medication blocks signals that rouse unkind B Cells to enhance and categorized overpoweringly throughout the body. It is not a drug treatment that uses powerful chemicals to kill fast-growing cells in your body, but this medication is called "targeted therapies." Targeted therapy is a cancer treatment that uses drugs to target specific genes and proteins that are involved in the growth and survival of cancer cells. Dosage: Take this medicine in the dose and duration as recommended by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ibrutinib 140 mg Capsules is to be taken with food. Side Effects: • Back pain •           body aches or pain •           cough • bloating or swelling of the face, arms, hands, lower legs, or feet • lower back or side pain • rapid weight gain • headache • Warnings: • CNS effects: May cause dizziness, fatigue, and/or weakness, which may impair physical or mental abilities; patients must be cautioned about performing tasks that require mental alertness (eg, operating machinery, driving). • GI toxicity: Diarrhea has been commonly observed; maintain adequate hydration. Progressive multifocal encephalopathy: Progressive multifocal encephalopathy has been observed; evaluate for symptoms and manage appropriately. • Renal toxicity: Renal failure has been reported with use; some cases were fatal. Clinical trials report serum creatinine increases of up to 3 × ULN; monitor renal function periodically and maintain hydration.

Notice: The information provided above is for educational aid only. Before using this medicine you should consult your doctor or pharmacist. Do not indulge yourself in self medication as it will be dangerous for you. If you have any query about medicine seeks help from your doctor or pharmacist. Related Key Terms: • Ibrutinib • Ibrutinib 140 mg price • Ibrutinib 140 mg tablet price in IRAQ • Ibrutinib 140 mg side effects • Ibrutinib Ibrukas in 140 mg FAQ: Q. What is the best price of Ibrutinib 140 mg Capsules in IRAQ? A. JS Pharmaceutical provides Ibrutinib 140 mg Capsules at relatively best price and with good discount on bulk order. Q. How to order Ibrutinib 140 mg  Capsules in IRAQ ? A. If you want to order this medicine in India please contact us on Whatsapp, Email or directly call us. We will deliver you medicine on time. Q. Who is the best supplier of Ibrutinib 140 mg  Capsules in IRAQ? A. JS Pharmaceutical is the best supplier of Ibrutinib 140 mg  Capsules in India and has good reviews by our customer. We value our customer time and feedback.   JS Pharmaceutical is also deals with other countries like USA Spain Russia Romania Cambodia Japan IRAQ KUWAIT, UAE(DUBAI), IRAN , SOUDII UNITED KINGDOM VIETNAM OMAN INDONESIA PERU

[thelotusbiotech]

Beyond Leukaemia: Understanding Blood Cancers and Available Treatment Frontiers

Introduction

While the term "blood cancer" often conjures the image of leukaemia, it encompasses a diverse and complex landscape of malignancies affecting the blood, bone marrow, and lymphatic system. This article delves beyond leukaemia, shedding light on various types of blood cancers and exploring the evolving landscape of treatment options.

Understanding Blood Cancers:

Blood cancers arise from uncontrolled growth and abnormal function of blood cells. These cells can be broadly categorized into:

Myeloid cells: These are responsible for immunity and forming various blood cell types. Abnormal growth in these cells leads to myelomas and myeloproliferative neoplasms.

Lymphoid cells: Play a crucial role in the immune system. Uncontrolled growth leads to lymphomas, such as Hodgkin's and non-Hodgkin's.

Plasma cells: Produce antibodies to fight infections—their abnormal growth results in plasma cell dyscrasias, including multiple myeloma.

Beyond Leukaemia: Unveiling the Diversity:

Leukaemia, lymphoma, myeloma, myelodysplastic syndromes (MDS), and myeloproliferative neoplasms (MPN) are among the different kinds of blood cancer. Each has a unique forecasting, course of therapy, and symptoms. It's common to categorise blood cancers as acute or chronic, wherein the former refers to rapid growth. In contrast, the latter refers to slower growth.

Leukaemia, though frequently mentioned, represents only a subset of blood cancers. Other types, each with unique characteristics and complexities, deserve our attention:

Characterised by the uncontrolled growth of lymphocytes, lymphomas can affect various lymph nodes and organs. Treatment approaches vary depending on the lymphoma type and stage.

Myeloma: Arising from plasma cells, multiple myeloma often affects bones and can cause kidney damage. Targeted therapies and bone marrow transplants play a crucial role in its management.

Myeloproliferative neoplasms (MPNs): A group of conditions characterised by the overproduction of blood cells, MPNs can include chronic myeloid leukaemia (CML), essential thrombocythemia, and polycythemia vera. Treatment focuses on controlling cell production and managing symptoms.

What are some common Signs and Symptoms of Blood Cancer?

Persistent fatigue: Feeling constantly tired, even after adequate rest

Unexplained weight loss: Losing weight unintentionally, especially when combined with fatigue.

Fever or night sweats: Fevers that don't resolve or excessive sweating at night can indicate an underlying infection or immune system issues.

Easy bruising or bleeding: Frequent or unusual bruising, bleeding gums, or nosebleeds.

Swollen lymph nodes: Lumps in your neck, armpits, or groin can be a sign your immune system is working overtime, potentially due to blood cancer.

Bone pain: Persistent or unexplained pain in your bones, joints, or back could be caused by bone marrow issues linked to blood cancers.

Changes in appetite: Loss of appetite or feeling full quickly, even after small meals, can be related to various cancers, including blood cancers.

Skin changes: Persistent rashes, itching, or red spots on your skin can sometimes be associated with blood cancers.

Frequent infections: Getting sick more often than usual, with infections that take longer to heal, could indicate weakened immunity linked to blood cancers.

Paleness, or pallor, is the appearance of white skin beneath your lower eyelid as opposed to pink.

Remember that it is crucial to seek professional medical advice for any suspected health concerns. Doctors can provide accurate diagnoses and personalised treatment plans based on individual needs.

Diagnostic Advancements: Navigating the Treatment Landscape

The advancements in diagnosing and treating blood cancers are remarkable. Traditional approaches like chemotherapy, radiation therapy, and bone marrow transplants remain cornerstones, but newer frontiers are emerging:

  These drugs pinpoint specific genetic mutations or proteins driving cancer growth, offering more precise and potentially less toxic treatment options.

Harnessing the body's immune system to recognize and attack cancer cells is revolutionising treatment, particularly for lymphomas and some leukemias.

CAR-T cell therapy, a form of immunotherapy where a patient's T cells are engineered to target cancer cells, has shown promising results for certain blood cancers.

This approach aims to correct genetic mutations responsible for cancer development, holding immense potential for future advancements.

Ibrunat 140mg Capsule: A Targeted Weapon Against B-Cell Blood Cancers

Ibrunat 140mg, also known as Ibrutinib capsules, has emerged as a hope for patients battling B-cell malignancies like chronic lymphocytic leukaemia (CLL) and mantle cell lymphoma. Unlike traditional chemotherapies, this targeted therapy zeroes in on a specific protein crucial for cancer cell survival – Bruton's tyrosine kinase (BTK).

Action Mechanism:

If BTK is a fuel regulator for cancer cells, Ibrunat 140mg acts like a wrench, effectively disrupting this regulator. By halting BTK's activity, the Ibrunat capsule throws a wrench into the cancer cell's machinery, hindering its growth and division and ultimately leading to its programmed cell death.

Advantages:

Ibrunat 140mg has established itself as a first-line treatment for this aggressive lymphoma, often leading to significant remission rates.

Ibrunat 140mg offers a powerful alternative, demonstrating improved outcomes compared to standard therapies.

Research is ongoing for using Ibrunat 140mg in other B-cell malignancies like Waldenstrom's macroglobulinemia and small lymphocytic lymphoma

Under proper medical guidance and supervision and with a valid prescription, one can buy ibrutinib online from various pharmaceutical distributors and traders such as The Lotus Biotech. Finding the right treatment path for B-cell cancers can be overwhelming. Exploring options like generic Ibrutinib, seeking financial assistance programs, and discussing alternatives with your doctor are crucial steps.

While Ibrunat 140mg isn't a cure-all, it represents a significant advancement in targeted cancer therapy. With continued research and increased accessibility, this "molecular wrench" holds immense promise for patients fighting B-cell blood cancers.

Looking Ahead: A Brighter Future?

The journey against blood cancers continues. While significant progress has been made, challenges remain. Some cancers develop resistance to existing therapies, highlighting the need for personalised medicine and continuous research. Additionally, ensuring equitable access to these advancements, particularly in resource-limited settings, is crucial.

Despite the challenges, the future of blood cancer treatment holds immense promise. Ongoing research in targeted therapies, immunotherapy, and gene therapy offers hope for more effective and personalised treatments. Early detection and diagnosis, combined with increased awareness and public health initiatives, can improve outcomes.

By delving beyond leukaemia and acknowledging the diverse spectrum of blood cancers, we can navigate the ever-evolving treatment landscape with greater understanding and hope. The dedication of researchers, healthcare professionals, and patients paves the way for a future where blood cancers are manageable and potentially curable.

[emedkitmedicine]

Ibrutinib 140 mg is an anti-cancer medication used for the treatment of B cell cancer like mantle cell lymphoma and some others. It is a small molecule drug that combines to protein Bruton’s Tyrosine Kinase (BTK) permanently, that is essential in B cells. Ibrutinib 140 mg Capsule Price at Emedkit is very low. Emedkit is a leading supplier and distributor of generic medicine along with injections in India and globally.

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[yesmedsdots]

Buy Imbruvica 140mg Capsules produced by Natco, used to treat certain cancers. Ibrutinib applies to a group of medicines known as kinase inhibitors. It works by slowing or stopping the growth of cancer blocks. that is caused by a defect in a generic named Ibrunat 140mg caps now available with MedsDots.Net. Buy Ibrutinib is generic for the trade anticancer medicine of Ibrunat 140mg capsules with Natco pharma plus other Asian countries. Get more extra info about Ibrutinib Ibrunat 140mg Capsules from MedsDots through WhatsApp and call on +91-9953810074, QQ: 3232648085, WeChat: medsdots, or mail: medsdotss@gmail.com.

[pharmaphorumuk]

Vyndaqel romps away in US, spurring earnings hike from Pfizer

Pfizer’s new drug for a rare heart disease – Vyndaqel – has shattered analysts’ sales forecasts in its first quarter on the market and looks set to quickly enter blockbuster territory.

Five months since becoming the first drug to be approved by the FDA for wild-type or hereditary transthyretin amyloid cardiomyopathy (ATTR-CM), Vyndaqel (tafamidis) has made $156 million in the third quarter, $77 million from the US.

Vyndaqel has previously been approved in European markets and Japan but not the US for hereditary transthyretin amyloid polyneuropathy (ATTR-PN), and while sales in that indication have been modest to date other approvals in ATTR-CM contributed to the drug’s growth.

The sales surge has come from the current four capsules-per-day formulation of the drug, with a one-pill-a-day version – called Vyndamax – launched in September that could further stimulate sales growth.

Previously, analysts said they were expecting Vyndaqel to top $1 billion in sales in 2024, but it seems that Pfizer’s drug is going to beat that timeframe on the back of rising rates of diagnosis helped by a shift from a biopsy approach to a non-invasive imaging technique called scintigraphy.

Vyndaqel’s gathering momentum – coupled with a 25% increase in sales of Pfizer’s blood cancer therapy Ibrance (ibrutinib) to $1.28 billion – helped Pfizer post better-than-expected third-quarter revenues of $12.7 billion.

Sales were down 5% overall in the quarter as Pfizer weathered the loss of patent protection and the start of generic competition for big-selling pain drug Lyrica (pregabalin), which dragged sales of its Upjohn division – due to be spun off and combined with Mylan – down 26%.

Albert Bourla

Nevertheless, Pfizer chief executive Albert Bourla said revenues for the full-year will now rise by mid-to-high single digits from an earlier prediction of low-to-mid single digits, with its forecast up by $700 million to $51.2-$52.2 billion.

The raised forecast is down to the performance of Vyndaqel and Ibrance but also other drugs including arthritis drug Xeljanz (tofacitinib), anticoagulant Eliquis (apixaban) and Inlyta (axitinib), which have benefited from approvals in combination with cancer immunotherapies for renal cell carcinoma.

That includes a dual regimen with Pfizer’s PD-1 inhibitor Bavencio (avelumab) approved by the European Commission this week for newly-diagnosed RCC, which came after an FDA approval for the combination earlier this year. Sales of Inlyta almost doubled to $139 million in the third quarter.

On a conference call, Bourla said the reshaped Pfizer that will follow the spin-off of Upjohn and the creation of a consumer health joint venture with GlaxoSmithKline will result in a leaner company that will be able to return annual growth of 6% over the next five years.

The company will not need to consider a big M&D deal, he added, and the business development strategy “will continue to be bolt-on, but we’ll have a focus on R&D” in particular phase 2 assets.

The post Vyndaqel romps away in US, spurring earnings hike from Pfizer appeared first on .

from https://pharmaphorum.com/news/vyndaqel-romps-away-in-us-spurring-earnings-hike-from-pfizer/

[yourleonthomasme-blog]

IBRUTINIB 70MG-Applepharmaceuticals

DESCRIPTION :

Imbruvica 70mg stops a protein in B cells called Bruton’s tyrosine kinase, or BTK. BTK indicating is required for B cells to multiply and survive. By inhibiting BTK, Imbruvica 70mg may help progress abnormal B cells out of their nourishing environments in the lymph nodes, bone marrow, and other organs. Imbruvica 70mgis a prescription drug which is used under the guidance by medical practioners .

INDICATION

Imbruvica 70mg is indicated for the treatment following condition Mantle cell lymphoma (MCL) who have getting at least one prior treatment Chronic lymphocytic leukaemia (CLL)/Small lymphocytic lymphoma (SLL) Chronic lymphocytic leukaemia (CLL)/Small lymphocytic lymphoma (SLL) with 17p deletion Waldenström macroglobulinemia (WM) Marginal zone lymphoma (MZL) who getting a medicine by mouth or injection (systemic therapy) and have getting a certain type of before treatment Chronic graft versus host disease (cGVHD) after failure of 1 or more lines of systemic therapy.

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[veronicaandrews-blog1]

IBRUTINIB [IMBRUVICA] - IMBRUVICA 70MG

DESCRIPTION

Imbruvica 70mg is a targeted drug aim to destroy the type of cell which has converted into cancerous orends signals which make cancerous cells develop or multiply. In lymphoma, the type of cell which becomes cancerous is called a ‘lymphocyte’ (a type of white blood cell that fights infection). There are different types of lymphocyte which can become cancerous. Imbruvica 70mg attacks B lymphocytes (B cells) and is therefore necessary to treat B-cell lymphomas.

INDICATION

Imbruvica 70mg is an antineoplastic drug which is: • Indicated for the treatment of Chronic lymphocytic leukaemia or small lymphocytic lymphoma • Indicated for the treatment of Mantle cell lymphoma • Indicated for the treatment of Waldenström Macroglobulinemia • Indicated for the treatment of Marginal Zone lymphoma • Indicated for the treatment of Graft vs Host Disease

MECHANISM OF ACTION

Ibrutinib prohibits the Bruton's tyrosine kinase (BTK)function. BTK is a basic signaling molecule of the B-cell receptor signaling complex which plays an important role in the endurance of malignant B cells. Ibrutinib stops signals whichprompt malignant B cells to develop and multiply uncontrollably. 

  ADME

Absorption: Time to peak plasma concentration of Imbruvica 70mg is 1-2 hours and drug taking with food will increases ibrutinib exposure. Distribution: Human plasma protein level is 97.3% and Vd is 10,000L Metabolism: Metabolized to several metabolites mainly by cytochrome P450 CYP3A, and to a minor extent by CYP2D6 Elimination: Imbruvica was excretion via feces 80% and urine 10 % Half-life of Imbruvica is 4-6 hours

DOSAGE MANAGEMENT

Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma : The usual dose of imbruvica is 420mg given three 140mg capsules per oral qDay While in concomitant use with bendamustine and rituximab the prescribed dose is 420mg PO qDay administrated q28d for up to 6 cycles until progression or undesirable toxicity Mantle Cell Lymphoma : The usualdose of imbruvica is 560mg given four 140mg-mg capsules PO qDay. Extend until disease progression or undesirable toxicity Waldenström Macroglobulinemia : The usualdose of imbruvicais 420mg given three 140mg capsules per oral qDay When concomitant use with rituximab is 420 mg PO qDay plus rituximab administered weekly for 4 consecutive weeks (weeks 1-4) continued by a second course of weekly rituximab for 4 consecutive weeks (weeks 17-20) Marginal Zone Lymphoma : The usualdose of imbruvica is 560mg given four 140mg-mg capsules PO qDay. Extend until disease progression or undesirable toxicity Graft vs Host Disease : The usualdose of imbruvica 70mg is 420mg given three 140mg capsules per oral qDay Extenduntil cGVHD development, relapsed of an underlying malignancy, or undesirable toxicity occurs

PRECAUTIONS

• While on treatment with Imbruvica 70mg Hypertension occurs with a median time to onset of 4.6 months; regulate for new onset hypertension or hypertension that is not enough controlled after starting ibrutinib • While on treatment with Imbruvica 70mg, Tumor lysis syndrome intermittently resulted; assess the baseline risk (e.g., high tumor burden) and take suitable precautions • While on treatment with Imbruvica 70mg Other malignancies (5-14%) resulted contains carcinomas (1-3%); the most frequent second primary malignancy was nonmelanoma skin cancer (4-11%) • When administered to a pregnant woman,based on findings in animals, can cause fetal risk • While on treatment with Imbruvica 70mg, lethal and severe cases of renal failure reported. 

  SIDE EFFECTS

More common side effects of Imbruvica 70mg : Fever, Stomatitis, Dizziness, Urinary Tract Infection, Pneumonia, Dyspepsia, Petechiae, Arthralgia, Nosebleeds, Skin infections, Asthenia, Muscle spasms, Shortness of breath, Constipation, Rash, Sinusitis, Headache, Dehydration, Abdominal pain, Vomiting, Decreased appetite, Cough. More common side effects of Imbruvica 70mg : Reduced neutrophils, Decreased haemoglobin, Fatigue, Bruising, Thrombocytopenia, Musculoskeletal pain, Swelling, Upper respiratory tract infection, Nausea, Diarrhea.

PREGNANCY

Pregnancy category is D;

While on treatment Imbruvica 70mg avoid becoming pregnancy and for up to 1 month after ending treatment.

LACTATION Avoid breast feeding during treatment with Imbruvica 70mg

STORAGE Store the drug at 20°C- 25°C

MISSED DOSE If missed dose occurs, have it immediately before next dose time reaches or missed dose should be avoid and follow the regular dosing schedule.

Must consult with doctor and follow the instructions given by them

CONTACT US 

MAIL ID : millionhealthpharmaceuticals@gmail.com PHONE NO : +91-9940472902 WEBSITE : https://millionpharma.com/ibrutinib-70mg.php

[walterlaake]

Doctors tried to lower $148K cancer drug cost; makers triple price of pill

(credit: Wellness GM)

A drug that treats a variety of white blood cell cancers typically costs about $148,000 a year, and doctors can customize and quickly adjust doses by adjusting how many small-dose pills of it patients should take each day—generally up to four pills. At least, that was the case until now.

Last year, doctors presented results from a small pilot trial hinting that smaller doses could work just as well as the larger dose—dropping patients down from three pills a day to just one. Taking just one pill a day could dramatically reduce costs to around $50,000 a year. And it could lessen unpleasant side-effects, such as diarrhea, muscle and bone pain, and tiredness. But just as doctors were gearing up for more trials on the lower dosages, the makers of the drug revealed plans that torpedoed the doctors’ efforts: they were tripling the price of the drug and changing pill dosages.

The drug, ibrutinib (brand name Imbruvica), typically came in 140mg capsules, of which patients took doses from 140mg per day to 560mg per day depending on their cancer and individual medical situation. (There were also 70mg capsules for patients taking certain treatment combinations or having liver complications.) The pills treat a variety of cancers involving a type of white blood cell called B cells. The cancers include mantle cell lymphoma, which was approved for treatment with four 140mg pills per day, and chronic lymphocytic leukemia, approved to be treated with three 140mg pills per day. Each 140mg pill costs somewhere around $133—for now.

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[toppropertydealers]

IBRUTINIB 140 MG Supplier in Russia

Brand Name: Ibrukas Active Ingredients: Ibrutinib Capsules 140 mg Manufactured by: AprazerForm. Strength: 140 mg Sellar                                   https://www.jspharmaceuticals.com/ Form: Capsules Packing: Pack of 100 Capsules

Description: Ibrukast Ibrutinib Capsules 140 mg is an aimed therapy. It prevents the function of Bruton``s Tyrosine Kinase (BTK). Bruton``s Tyrosine Kinase is an important gesturing molecule of the B-cell receptor signaling complex that plays a significant role in the endurance of menacing B Cells. This medication blocks signals that rouse unkind B Cells to enhance and categorized overpoweringly throughout the body. It is not a drug treatment that uses powerful chemicals to kill fast-growing cells in your body, but this medication is called "targeted therapies." Targeted therapy is a cancer treatment that uses drugs to target specific genes and proteins that are involved in the growth and survival of cancer cells. Dosage: Take this medicine in the dose and duration as recommended by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ibrutinib 140 mg Capsules is to be taken with food. Side Effects: • Back pain •           body aches or pain •           cough • bloating or swelling of the face, arms, hands, lower legs, or feet • lower back or side pain • rapid weight gain • headache • Warnings: • CNS effects: May cause dizziness, fatigue, and/or weakness, which may impair physical or mental abilities; patients must be cautioned about performing tasks that require mental alertness (eg, operating machinery, driving). • GI toxicity: Diarrhea has been commonly observed; maintain adequate hydration. Progressive multifocal encephalopathy: Progressive multifocal encephalopathy has been observed; evaluate for symptoms and manage appropriately. • Renal toxicity: Renal failure has been reported with use; some cases were fatal. Clinical trials report serum creatinine increases of up to 3 × ULN; monitor renal function periodically and maintain hydration.

Notice: The information provided above is for educational aid only. Before using this medicine you should consult your doctor or pharmacist. Do not indulge yourself in self medication as it will be dangerous for you. If you have any query about medicine seeks help from your doctor or pharmacist. Related Key Terms: • Ibrutinib • Ibrutinib 140 mg price • Ibrutinib 140 mg tablet price in IRAQ • Ibrutinib 140 mg side effects • Ibrutinib Ibrukas in 140 mg FAQ: Q. What is the best price of Ibrutinib 140 mg Capsules in IRAQ? A. JS Pharmaceutical provides Ibrutinib 140 mg Capsules at relatively best price and with good discount on bulk order. Q. How to order Ibrutinib 140 mg  Capsules in IRAQ ? A. If you want to order this medicine in India please contact us on Whatsapp, Email or directly call us. We will deliver you medicine on time. Q. Who is the best supplier of Ibrutinib 140 mg  Capsules in IRAQ? A. JS Pharmaceutical is the best supplier of Ibrutinib 140 mg  Capsules in India and has good reviews by our customer. We value our customer time and feedback.   JS Pharmaceutical is also deals with other countries like USA Spain Russia Romania Cambodia Japan IRAQ KUWAIT, UAE(DUBAI), IRAN , SOUDII UNITED KINGDOM VIETNAM OMAN INDONESIA PERU