#Haloplex

[axsteroidsus]

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[mk-anabolics]

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[theshadowytastemakerstuden-blog1]

Global Exome Sequencing Market Outlook 2022 & Key Players: Illumina TruSeq Exome, Thermo Fisher, Roche

Exome Sequencing Market report includes an extensive analysis of key industry drivers, restraints, market trends, and market structure. The key players in Exome Sequencing Market are particularly focusing on acquisitions, mergers, expansion, distribution, and adoption of new technologies. Exome Sequencing Market study provides a comprehensive assessment of stakeholder strategies and imperatives for succeeding in the business.

In 2018, the global Exome Sequencing market size was million US$ and it is expected to reach million US$ by the end of 2025, with a CAGR of during 2019-2025.

For more info, Get Free Sample at: https://www.researchmoz.us/enquiry.php?type=S&repid=230272

This report focuses on the global Exome Sequencing status, future forecast, growth opportunity, key market and key players. The study objectives are to present the Exome Sequencing development in United States, Europe and China.

The key players covered in this study Illumina TruSeq Exome Thermo Fisher Roche Angilent Eurofins Sengenics Ambry Macrogen BGI Novo Gene

Market segment by Type, the product can be split into Agilent HaloPlex Agilent SureSelect Agilent SureSelect QXT Illumina TruSeq Exome Roche Nimblegen SeqCap MYcroarray MYbaits

Market segment by Application, split into Mendelian disease and rare syndrome gene discovery The research of complex diseases Mouse exome sequencing

Make an Enquiry at: https://www.researchmoz.us/enquiry.php?type=E&repid=2302723

Market segment by Regions/Countries, this report covers United States Europe China Japan Southeast Asia India Central & South America

The study objectives of this report are: To analyze global Exome Sequencing status, future forecast, growth opportunity, key market and key players. To present the Exome Sequencing development in United States, Europe and China. To strategically profile the key players and comprehensively analyze their development plan and strategies. To define, describe and forecast the market by product type, market and key regions.

In this study, the years considered to estimate the market size of Exome Sequencing are as follows: History Year: 2014-2018 Base Year: 2018 Estimated Year: 2019 Forecast Year 2019 to 2025

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[cancersfakianakis1]

P04.85 Molecular characteristics of low grade glioma progression

Abstract

Background

Low grade glioma (LGG), especially oligodendroglioma (ODG), are known for their usually good response to radio- and chemotherapy and relatively good prognosis amongst glioma. LGG can stay indolent after initial surgery for years, however many will eventually progress to higher grade tumor, although the pace of progression can differ greatly. Temozolomide administered after resection has been shown to promote a hypermutated recurrent tumor, however, not all patients receive postoperative chemotherapy. We investigated changes in the molecular profiles of genes involved in glioma development between primary and recurrent tumor.

Material and Methods

Eight pairs of tumors, from 6 males and 2 females diagnosed with LGG, were collected between 2008–2015. Three patients received chemo- or radiotherapy between surgeries. 1p19q co-deletion was assessed by droplet digital PCR and IDH mutations by Sanger sequencing. A glioma tailored HaloPlex NGS panel was created with 24 genes and 7 hotspot mutations (IDH1/2 TERT, ATRX, TP53, NF1/2, EGFR, CDKN2A/2B/2C, PTEN, PIK3CA, PIK3R1, CIC, FUBP1, RB1, MLH1/3, MSH2/3/5/6, PMS1/2, BRAF, H3F3A, LRIG1-3, NRAS). Library preparation was followed by Illumina sequencing on MiSeq. Variants were reported if missense or nonsense change was discovered and population allele frequency below 0.01. Transcriptome microarray data from the samples was used for hierarchical clustering and differential expression analysis.

Results

Three pairs of tumors did not show 1p19q co-deletion, out of which one was IDHwt and excluded. Tumors non-codeleted and IDH mutated were diffuse astrocytoma and IDHmut and codeleted tumors were ODG. The seven pairs of tumors were subjected to targeted resequencing and several variants were found. All IDH1mut were confirmed. SIFT and PolyPhen predicted damaging variants were found in FUBP1, CIC, TP53, EGFR, NF1, RB1, ATRX, TERT, CDKN2A, PIK3CA, MLH1 and MSH5. All variants were shared between primary and recurrent tumors, apart from 2 pairs. Mutations found in FUBP1 and CIC in the primary tumor of one ODG patient were absent at recurrence; both tumors were grade II. In an ODG that progressed from grade II to grade III a mutation in PIK3CA was detected at recurrence while a variant in NF1 was lost. Hierarchical clustering showed a good separation of primary and recurrent tumors and nearly 200 differentially expressed genes with 2-fold change were discovered, including up-regulation of the Rho family GTPase3, CHEK1, CDKN2C, CDKN3 and several others.

Conclusion

LGG are relatively stable in their mutational profile at recurrence in the genes analyzed. Mutations in genes thought to be drivers in ODG, like CIC and FUBP1 are not always retained in the recurrent tumor. Differences in expression profiles of primary and relapsed tumors indicate common changes during progression, however an expanded cohort studies are needed for their elucidation. https://ift.tt/2QIfN5Z

[reporthive-blog]

Global Exome Sequencing Market Size, Status and Forecast 2022

This report studies the global Exome Sequencing market, analyzes and researches the Exome Sequencing development status and forecast in United States, EU, Japan, China, India and Southeast Asia.

This report focuses on the top players in global market, like Illumina TruSeq Exome Thermo Fisher Roche Angilent Eurofins Sengenics Ambry Macrogen BGI Novo Gene

Request a sample of this report @ https://www.reporthive.com/enquiry.php?id=1046058&req_type=smpl

Market segment by Regions/Countries, this report covers United States EU Japan China India Southeast Asia

Market segment by Type, Exome Sequencing can be split into Agilent HaloPlex Agilent SureSelect Agilent SureSelect QXT Illumina TruSeq Exome Roche Nimblegen SeqCap MYcroarray MYbaits

Market segment by Application, Exome Sequencing can be split into Mendelian disease and rare syndrome gene discovery The research of complex diseases Mouse exome sequencing

If you have any special requirements, please let us know and we will offer you the report as you want.

Enquiry For Report Purchase @ https://www.reporthive.com/enquiry.php?id=1046058&req_type=purch

Major Points From Table of Content

1 Industry Overview of Exome Sequencing 2 Global Exome Sequencing Competition Analysis by Players

3 Company (Top Players) Profiles 3.1 Illumina TruSeq Exome 3.1.1 Company Profile 3.1.2 Main Business/Business Overview 3.1.3 Products, Services and Solutions 3.1.4 Exome Sequencing Revenue (Value) (2012–2017) 3.1.5 Recent Developments

3.2 Thermo Fisher 3.2.1 Company Profile 3.2.2 Main Business/Business Overview 3.2.3 Products, Services and Solutions 3.2.4 Exome Sequencing Revenue (Value) (2012–2017) 3.2.5 Recent Developments

3.3 Roche 3.3.1 Company Profile 3.3.2 Main Business/Business Overview 3.3.3 Products, Services and Solutions 3.3.4 Exome Sequencing Revenue (Value) (2012–2017) 3.3.5 Recent Developments

3.4 Angilent 3.4.1 Company Profile 3.4.2 Main Business/Business Overview 3.4.3 Products, Services and Solutions 3.4.4 Exome Sequencing Revenue (Value) (2012–2017) 3.4.5 Recent Developments

3.5 Eurofins 3.5.1 Company Profile 3.5.2 Main Business/Business Overview 3.5.3 Products, Services and Solutions 3.5.4 Exome Sequencing Revenue (Value) (2012–2017) 3.5.5 Recent Developments

3.6 Sengenics 3.6.1 Company Profile 3.6.2 Main Business/Business Overview 3.6.3 Products, Services and Solutions 3.6.4 Exome Sequencing Revenue (Value) (2012–2017) 3.6.5 Recent Developments

3.7 Ambry 3.7.1 Company Profile 3.7.2 Main Business/Business Overview 3.7.3 Products, Services and Solutions 3.7.4 Exome Sequencing Revenue (Value) (2012–2017) 3.7.5 Recent Developments

3.8 Macrogen 3.8.1 Company Profile 3.8.2 Main Business/Business Overview 3.8.3 Products, Services and Solutions 3.8.4 Exome Sequencing Revenue (Value) (2012–2017) 3.8.5 Recent Developments

3.9 BGI 3.9.1 Company Profile 3.9.2 Main Business/Business Overview 3.9.3 Products, Services and Solutions 3.9.4 Exome Sequencing Revenue (Value) (2012–2017) 3.9.5 Recent Developments

3.10 Novo Gene 3.10.1 Company Profile 3.10.2 Main Business/Business Overview 3.10.3 Products, Services and Solutions 3.10.4 Exome Sequencing Revenue (Value) (2012–2017) 3.10.5 Recent Developments

Read More…

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