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priteshwemarketresearch · 21 days

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Obinutuzumab Market by Platform, Type, Technology and End User Industry Statistics, Scope, Demand with Forecast 2034

The Growing Obinutuzumab Market: Trends, Opportunities, and Future Outlook

In recent years, the pharmaceutical landscape has been significantly shaped by advances in targeted therapies. One standout in this realm is Obinutuzumab, a monoclonal antibody that's garnering increasing attention for its role in treating various cancers. As the demand for innovative treatments continues to rise, the Obinutuzumab market is experiencing notable growth. In this blog, we'll explore the key trends driving the Obinutuzumab market, opportunities for stakeholders, and what the future holds for this promising therapy.

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What is Obinutuzumab?

Obinutuzumab, marketed under the brand name Gazyva, is a monoclonal antibody developed for the treatment of certain types of cancers, primarily chronic lymphocytic leukemia (CLL) and follicular lymphoma. It works by targeting and binding to the CD20 antigen on the surface of B-cells, leading to their destruction. This mechanism of action makes Obinutuzumab a valuable therapeutic option for patients with these malignancies.

Obinutuzumab Market Dynamics

Rising Prevalence of Blood Cancers: The increasing incidence of blood cancers worldwide is a primary factor driving market expansion.

Drug Efficacy: Obinutuzumab's proven efficacy and relatively manageable side effect profile have contributed to its market success.

Expanding Indications: Ongoing research is exploring the potential of obinutuzumab in treating other hematological malignancies.

Competitive Landscape: The presence of other monoclonal antibodies and emerging treatment options poses competition to obinutuzumab.

Key Trends in the Obinutuzumab Market

Growing Incidence of Hematologic Cancers: The rising prevalence of hematologic cancers such as CLL and follicular lymphoma is a major driver of the Obinutuzumab market. With an increasing number of diagnoses globally, the demand for effective treatments like Obinutuzumab is expected to grow.

Advancements in Treatment Protocols: Ongoing research and clinical trials are continually enhancing the understanding of Obinutuzumab's efficacy and safety. New combination therapies and novel treatment regimens involving Obinutuzumab are being developed, contributing to its expanding use.

Increased Focus on Targeted Therapies: The shift towards personalized medicine and targeted therapies has highlighted the importance of drugs like Obinutuzumab. Its specific targeting of cancer cells minimizes damage to healthy tissues, leading to improved patient outcomes and fewer side effects.

Regulatory Approvals and Expansions: Recent regulatory approvals and the expansion of Obinutuzumab's indications are further fueling market growth. As more approvals are granted for additional types of cancers or combinations with other therapies, the market potential for Obinutuzumab is set to increase.

Opportunities in the Obinutuzumab Market

Emerging Markets: While Obinutuzumab is already established in several developed countries, there is significant potential in emerging markets. As healthcare infrastructure improves and access to advanced treatments expands, these regions are expected to become key growth areas for Obinutuzumab.

Collaborations and Partnerships: Pharmaceutical companies and research institutions are exploring collaborations to enhance the development and distribution of Obinutuzumab. Strategic partnerships can lead to innovative treatment solutions and broader market reach.

Patient-Centric Approaches: Tailoring treatment approaches to individual patient needs and preferences can drive market growth. By focusing on personalized treatment plans, stakeholders can improve patient outcomes and satisfaction, thereby increasing adoption rates of Obinutuzumab.

Market Challenges and Opportunities

High Drug Cost: The price of obinutuzumab can be a significant burden for patients and healthcare systems.

Reimbursement Hurdles: Gaining insurance coverage for the drug can be challenging in some regions.

Biosimilar Competition: The entry of biosimilar obinutuzumab products could impact market dynamics.

Emerging Markets: Expanding market penetration in developing countries presents significant growth opportunities.

Combination Therapies: Exploring the potential of obinutuzumab in combination with other therapies to improve outcomes.

Personalized Medicine: Utilizing genetic and molecular profiling to optimize treatment decisions.

Future Outlook

The future of the Obinutuzumab market looks promising, driven by ongoing research, regulatory advancements, and a growing patient population. As new indications and combinations are explored, Obinutuzumab's role in oncology is likely to expand. Additionally, advancements in biotechnology and precision medicine will continue to shape the landscape of targeted therapies, providing new opportunities for Obinutuzumab and similar drugs.

Conclusion

The Obinutuzumab market is on a trajectory of growth, propelled by an increasing need for effective cancer treatments and ongoing advancements in medical research. For stakeholders, including pharmaceutical companies, healthcare providers, and patients, the evolving landscape presents both challenges and opportunities. By staying informed about market trends and investing in research and development, the future of Obinutuzumab looks bright, promising enhanced treatment options and improved outcomes for patients worldwide.

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thebrokencrescent-blog · 1 year

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📆 June 13, 2023 📰 Strategies for complete B-cell depletion evolve for patients with lupus nephritis

SEOUL, SOUTH KOREA – B cell–depleting therapies in patients with lupus nephritis have a higher likelihood of complete response if B cells are almost completely depleted, and strategies for achieving more complete B-cell depletion continue to be tested, according to evidence presented by Richard A. Furie, MD, at an international congress on systemic lupus erythematosus (SLE).

“If you go back about 20 years ago or so, when we designed the LUNAR and EXPLORER trials, we were scared to death of rituximab [Rituxan and biosimilars], about what would happen when you deplete B cells,” said Dr. Furie, chief of the division of rheumatology at Northwell Health in New York.

The LUNAR trial, which compared rituximab with placebo in patients with lupus nephritis, did not show a statistically significant difference in renal outcomes at 1 year. However, a post hoc analysis done several years later told a different story. It looked at patients who achieved complete peripheral depletion of B cells, defined as zero cells per microliter in peripheral blood. “You can see about a fourfold increase in complete response rates in those who were complete B-cell depleters at 1 year,” Dr. Furie told the conference.

It therefore raises the question of how to achieve greater B-cell depletion rates in patients. Dr. Furie said one strategy might be to first mobilize memory B cells and neutralize B cell–activating factor using belimumab (Benlysta), and then treat with rituximab to eliminate B cells. This strategy of sequential belimumab-rituximab treatment has been taken in several clinical trials.

More potent B-cell depletion with obinutuzumab

Another approach is to choose more potent B cell–depleting therapies, such as obinutuzumab (Gazyva), which is an anti-CD20 monoclonal antibody that was approved in 2013 for the treatment of chronic lymphocytic leukemia.

The NOBILITY trial compared obinutuzumab with placebo in 125 patients with lupus nephritis who were on background treatment with mycophenolate and corticosteroids. At 1 year, significantly more patients achieved B-cell thresholds either below 5 cells per microliter or even zero cells per microliter than had been seen previously with rituximab.

That also translated into clinical benefit, Dr. Furie said. By week 76, half the patients who had sustained depletion of B cells below 0.4 cells per microliter had a complete response, compared with 35% of those who still had detectable B cells and 18% of the placebo group. Treatment with obinutuzumab did not show any link to higher rates of serious adverse events, serious infections, or deaths.

“I think we’re all pretty much convinced more is better, without introducing safety issues,” Dr. Furie said in an interview.

Joan Merrill, MD, professor of medicine at the University of Oklahoma Health Sciences Center, Oklahoma City, said the data did suggest that renal outcomes were better with more complete depletion, but raised the question of whether this might increase the risk of infections or infectious severity.

Dr. Furie noted that complete response not only required improvement in proteinuria, complement levels, and anti–double-stranded DNA antibodies, but also in serum creatinine, “because maintenance of eGFR [estimated glomerular filtration rate] is the name of the game with lupus nephritis.”

However, he also pointed out that there may be a ceiling for response rates in patients with lupus nephritis when using stricter endpoints for serum creatinine. The NOBILITY trial required patients to achieve a serum creatinine that did not increase by more than 15% from baseline. But when researchers did an analysis that instead only required patients to achieve a reduction in proteinuria and maintain normal creatinine, the complete response rate in complete B-cell depleters increased to 72%, compared with 50% in partial depleters and 37% in the placebo group.

Newer strategies for greater B-cell depletion

A third strategy for achieving greater B-cell depletion is bispecific T-cell engagers, or BiTEs. “I called it a ‘frenemy,’ where it’s taking the activated T cell and introducing it to the B cell, and it can kill it via direct T-cell killing,” Dr. Furie said in an interview. Mosunetuzumab (Lunsumio) is one example, and is currently in a phase 1 clinical trial of patients with SLE.

And the fourth strategy, which has proved so successful in lymphoma, is chimeric antigen receptor T-cell therapy (CAR T). Dr. Furie cited the recent publication of data from a CAR T clinical trial in five patients with refractory SLE. He said the data were impressive but the question for this treatment approach will be which patients are most likely to benefit and whether CAR T will experience the same ceiling effect because of pre-existing kidney damage.

“We won’t be seeing 100% response rates,” he said. “What we’ll be seeing, as a maximum, might be about 70%.” The big question for B-cell depletion in lupus was therefore how best to achieve it. “Is the future a potent monoclonal antibody, or is it in fact CAR T?”

Dr. Merrill said the analyses from B-cell depletion trials, showing greater response rates among more complete depleters, highlighted the importance of a personalized approach to treating lupus.

“One size fits all is never optimal in any disease, but it will prove a nonstarter in lupus, where we ought to be trying to find the optimal treatment regimen for each patient guided by biomarkers,” she said in an interview.

Dr. Furie reported having financial relationships with Genentech/Roche, which manufactures obinutuzumab and rituximab, as well as GlaxoSmithKline, Kezar Life Sciences, Kyverna Therapeutics, and Takeda. Dr. Merrill reported consulting for and receiving research support from a range of pharmaceutical companies including Genentech/Roche, GlaxoSmithKline, Pfizer, Janssen, Bristol-Myers Squibb, AbbVie, and AstraZeneca.

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mrunalnerkarblog · 2 years

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Fc Protein and Glycoengineered Antibodies Market Is Booming Worldwide 2023-2028

Global Fc Protein and Glycoengineered Antibodies Market Drivers

Key players in the market are focusing on research and development activities and receiving approvals from regulatory bodies, which are expected to boost the global Fc protein and glycoengineered antibodies market growth over the forecast period.

For instance, in 2016, Genentech Inc. received approval from the U.S. Food and drug Administration (U.S. FDA) for Tecentriq (Atezolizumab). It is being used for the treatment of urothelial carcinoma. In March 2019, Tecentriq received its second approval from the U.S. FDA for the treatment of small lung cancer. Furthermore, in November 2017, TG Therapeutics, Inc. began its clinical trial of Ublituximab for the treatment of multiple sclerosis. It is currently in third phase of its clinical trial. Factors such as increasing product approvals and robust pipeline are expected to drive the global fc protein and glycoengineered antibodies market growth.

Increasing prevalence of diseases such as cancer is expected to propel the global Fc protein and glycoengineered antibodies market growth. According to the World Health Organization (WHO), cancer is considered as the second most leading cause of death worldwide, and, in 2018, around 9.6 million people died worldwide due to cancer. Hence, glycoengineered antibodies can be developed for the treatment of cancer and thus, this factor is expected to drive growth of the global fc protein and glycoengineered antibodies market over the forecast period.

Global Fc Protein and Glycoengineered Antibodies Market Restraints

High cost of drugs is expected to hinder the global Fc protein and glycoengineered antibodies market growth. Manufacturers are focused on offering a highly effective drug, thus investing more into research and development activities. This increases the final cost price of the product. According to Pharmacy and Healthcare Communication, LLC, Gazyva costs around US$ 41,300 for six months treatment of cancer. Hence, this factor is expected to restrain growth of the global fc protein and glycoengineered antibodies market.

Global Fc Protein and Glycoengineered Antibodies Market Regional Analysis

North America region is expected to dominate in the global fc protein and glycoengineered antibodies market due to factors such as product launches, presence of leading manufacturers (such as F. Hoffmann La-Roche Ltd.), and active research and development in the field. Drugs such as Obinutuzumab (Gazyva), Mogamulizumab (Poteligeo), Atezolizumab (Tecentriq), and Durvalumab (Imfinzi) have been approved in the U.S. in 2013, 2018, 2016, and 2017 respectively.

#Fc Protein and Glycoengineered Antibodies Market

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lucadezzani · 6 years

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Top News from EHA 2018

All The Most Important News and Updates form EHA 2018 Novartis survey uncovers real-world impact of immune thrombocytopenia (ITP) on patients’ quality of life

June 15, 2018

Many patients with the rare blood disorder immune thrombocytopenia (ITP) find the disease has a negative impact on their everyday quality of life, according to interim results of a Novartis survey, called I-WISh, presented at…

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coco-manus-blog · 7 years

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FDA backs Roche's Gazyva in first-line follicular ... - https://goo.gl/hhP5NN - #Backs, #FDA, #Firstline, #Follicular, #Gazyva, #Nutrition, #Roche039S

#backs #FDA #firstline #follicular #Gazyva #nutrition #Roche039s

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venclyxto · 2 years

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Venclyxto

Some forms of chronic lymphocytic leukemia, or white blood cell cancer, are treated with venetoclax (SLL; a type of cancer that begins mainly in the lymph nodes). As a first-line treatment for AML acute myeloid leukemia (cancer of the white blood cells) in adults aged 75 and older or in those with medical conditions that prevent them from receiving other chemotherapy drugs, this drug may be administered alone or in combination with obinutuzumab (Gazyva), rituximab (Rituxan), azacitidine (Vidaza), decitabine (Dacogen), or cytarabine. Venetoclax is a member of the class of medications known as B-cell lymphoma-2 (BCL-2) inhibitors. It operates by inhibiting an internal protein from supporting cancer cells in surviving. This assists in the elimination of cancerous cells.

Venclyxto's Operation

The active component of Venclyxto, venetoclax, interacts with the Bcl-2 protein. Leukemia cancer cells contain high levels of this protein, which helps the cells survive longer in the body and develop resistance to cancer treatments. Venetoclax stops Bcl-2 from doing its job, which prevents the illness from progressing while killing cancer cells.

How Do You Use Venclyxto Capsules? Venclyxto is only available with a valid prescription and should only be started and treated by a doctor with experience in cancer treatments. It is available as tablets (10, 50, and 100 mg), which should be taken once daily with food.

Starting at 20 mg daily, the dose of Venclyxto Capsules for CLL is gradually increased to 400 mg daily over the course of five weeks. The dosage is then maintained at 400 mg per day for the duration of the treatment, which is dependent on the drug it is given. As long as the drug is effective when taken by itself, Venclyxto is given. A 100 mg starting dose for AML is raised over three

What are Venclyxto's Side Effects? Anemia and a decrease in neutrophils were the two most frequent significant adverse effects. Pneumonia, sepsis (blood poisoning), urinary tract infection (infection of the structures that carry urine), neutropenia (low levels of neutrophils, a type of white blood cells) with or without fever, anemia, thrombocytopenia (low levels of blood platelets), hypokalaemia (low levels of potassium), decreased appetite, dizziness, headache, nausea, diarrhea, vomiting, and stomatitis (in the mouth) are the most frequent side effects (high blood levels of bilirubin, a breakdown product of red blood cells, which can cause yellowing of the skin and eyes).

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rootsanalysis · 3 years

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The Fc protein and glyco-engineered antibodies market is projected to grow at a CAGR of over 30% during 2021-2030, claims Roots Analysis

With the emergence of blockbuster drugs, such as Gazyva® (for Chronic Lymphocytic Leukemia) and POTELEGIO® (for Sézary syndrome), Fc engineered antibodies have garnered significant interest in the medical community, for various clinical conditions

London

Roots Analysis has announced the addition of “Fc Protein and Glyco-engineered Antibodies Market, 2021-2030” report to its list of offerings.

Over time, a substantial body of evidence has validated the therapeutic applications of Fc engineering platforms; Fc modified antibodies have shown to augment the various immune effector functions, such as antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), antibody-dependent cellular phagocytosis (ADCP) activity and / or the half-life of the molecule

To order this 250+ page report, which features 100+ figures and 110+ tables, please visit https://www.rootsanalysis.com/reports/fc-protein-engineered-and-glycoengineered-antibodies-market.html

Key Market Insights

The Fc engineered antibodies pipeline features more than 125 marketed drugs / drug development programs

Around 15% Fc protein and glyco-engineered antibodies are marketed, while close to 75% are being evaluated in different phases of clinical trials and 10% in preclinical studies. Examples of marketed Fc engineered antibodies include Gazvya®, Imfinzi®, MONJUVI® and Skyrizi®.

Around 30 companies claim to be engaged in the development of Fc protein and glyco-engineered antibodies

Around 55% of the aforementioned players are large companies (with more than 5000 employees). It is worth highlighting that, majority of the developers engaged in this domain (54%) are based in North America, followed by Europe (26%) and Asia-Pacific (20%).

Over 1,800 clinical trials are currently evaluating the therapeutic effects of Fc protein and glyco-engineered antibodies, worldwide

It is worth mentioning that most of the trials were / are being conducted in North America (35%) region;

however, more than 91% of the patients enrolled in trials conducted in North America were enrolled in different sites in the United States. Further, 43% of the trials are being sponsored by non-industry players.

Close to 140 grants have been awarded to support research on Fc protein and glyco-engineered antibodies, since 2019

An estimated USD 63 million in grants have been awarded to various companies / organizations working in this domain, during time period between 2019 and 2021. Almost 50% of the total grant amount was funded by the National Institute of Allergy and Infectious Diseases.

Close to 6,500 patents have been filed / granted for Fc protein and glyco-engineered antibodies, since 2016

Around 30% of these intellectual property documents were filed / granted in the Asia-Pacific; with maximum number of patents filed in Australia. This is followed by North America (32%) and Europe (23%). Leading industry players (in terms of the size of intellectual property portfolio) include Roche, Janssen, Novartis, Genentech, Amgen, MacroGenics and Genmab.

Partnership activity within this domain has grown at a CAGR of 48%, between 2016 and 2020 More than 50% of the total deals have been inked post 2019. Licensing (36%) emerged as the most popular type of partnership model adopted by stakeholders in this domain, followed by clinical trial agreements (16%) and acquisitions / mergers (14%).

The market is anticipated to grow at a CAGR of over 30%, during the period 2021-2030

Growth in this domain is anticipated to be driven by the drugs that are being developed for the treatment of oncological disorders. North America (primarily the US) and Europe are expected to capture major share of the Fc protein and glyco-engineered antibodies market by 2030, in terms of the sales-based revenues.

To request a sample copy / brochure of this report, please visit this https://www.rootsanalysis.com/reports/fc-protein-engineered-and-glycoengineered-antibodies-market/request-sample.html

Key Questions Answered

§ Who are the leading industry and non-industry players engaged in the development of Fc protein and glyco-engineered antibodies?

§ Which are the key disease indications being targeted by Fc engineered antibodies?

§ Which partnership models are commonly adopted by stakeholders engaged in this domain?

§ Which geographies are the most active in conducting clinical trials on Fc protein and glyco-engineered antibodies?

§ Which are the leading administering institutes supporting the research related to Fc protein and glyco-engineered antibodies?

§ How has the intellectual property landscape in this market evolved over the years?

§ Which key factors are likely to influence the evolution of this market?

§ How is the current and future market opportunity likely to be distributed across key market segments?

The financial opportunity within the Fc protein and glyco-engineered antibodies market has been analyzed across the following segments:

§ Type of Fc Engineering

§ Fc Protein Engineering

§ Fc Glyco-engineering

§ Type of Therapy

§ Monotherapy

§ Combination Therapy

§ Therapeutic Area

§ Oncological Disorders

§ Rare Disorders

§ Dermatological Disorders

§ Autoimmune Disorders

§ Infectious Diseases

§ Gastrointestinal Disorders

§ Neurological Disorders

§ Pulmonary Disorders

§ Route of Administration

§ Intravenous

§ Subcutaneous

§ Others

§ Key Geographical Regions

§ North America

§ Europe

§ Asia-Pacific

§ Rest of the World

The research includes profiles of key players (listed below); each profile features an overview of the company, its financial information (if available), brief description of its drug(s), recent developments, and an informed future outlook.

§ AbbVie

§ Alexion Pharmaceuticals

§ AstraZeneca

§ Genentech

§ MacroGenics

§ Kyowa Kirin

For additional details, please visit

https://www.rootsanalysis.com/reports/fc-protein-engineered-and-glycoengineered-antibodies-market.html

or email [email protected]

You may also be interested in the following titles:

1. TIL-based Therapies Market, 2021-2030

2. TCR-based Therapies Market, 2021-2030

3. Peptide Therapeutics Market, 2021-2030

Contact Details

Ben Johnson

+1 (415) 800 3415

[email protected]

Roots Analysis

Web: https://www.rootsanalysis.com/

LinkedIn: https://in.linkedin.com/company/roots-analysis

Twitter: https://twitter.com/RootsAnalysis.com

Medium: https://medium.com/@RootsAnalysis

Pinterest: https://in.pinterest.com/RootsanalysisPin/_saved/

Quora: https://rootsanalysisinsights.quora.com/

#glyco-engineered #antibodies market #engineered antibodies #Rootsanalysis

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marketreports-world · 3 years

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Global Chronic Lymphocytic Leukemia Treatment Market - Forecast Till 2027

Chronic Lymphocytic Leukemia Treatment Market Research Report: by Type (Indolent & Aggressive), by Treatment (Chemotherapy, Targeted Drug Therapy, Immunotherapy & Bone Marrow Transplant), by End User (Hospitals & Clinics & Others) - Global Forecast Till 2027

Market Scenario

As per the data experts at Market Research Future (MRFR), the chronic lymphocytic leukemia treatment market was worth USD 7.9 Billion in 2017. Additionally, the market is expected to expand at a growth rate of 19% over the forecast period (2018-2023).

Market Drivers and Key Challenges

Chronic lymphocytic leukemia is considered to be one of the most common types of leukemia in adults. This type of cancer involves the development of lymphocytes, which are white blood cells, within the bone marrow. The lymphocytic leukemia cells are generally present in the lymph nodes along with various other tissues. There are two primary types of chronic lymphocytic leukemia, wherein one grows slowly, and the other is considered fatal. In general, one does not experience any symptoms due to chronic lymphocytic leukemia for a long period. However, the symptoms usually noted include fatigue, easy bruising, and swollen lymph nodes.

Generally, the most popular form of treatment for CLL is chemotherapy, whereas stem-cell transplant is for rare cases. An article published by Apollo Hospitals states that in India, roughly one million cases of chronic lymphocytic leukemia are diagnosed annually. As per the cancer statistics, 1 in every 155 men and 1 in every 260 women get affected with CLL in their lifetime, in the United Kingdom (U.K). The boost in cancer cases around the world, innovations in drug therapy, quick regulatory approval processes, and vigorous pipeline of drugs for chronic lymphocytic leukemia treatment are additional factors substantiating the growth of the chronic lymphocytic leukemia market.

Having said that, the stunted level of awareness with regard to symptoms is expected to retard the market growth in the forthcoming years. However, growing research & development activities coupled with continuous technological developments in the field is presumed to augment the market growth to a large extent.

Market Segmentation

The global chronic lymphocytic leukemia treatment market has been segmented on the basis of type, treatment, and end user.

The market, in terms of the type, has been considered for indolent CLL and aggressive CLL.

The market, treatment-wise, can be broken down into chemotherapy, targeted drug therapy, immunotherapy, and bone marrow transplant.

The end users in the global market are hospitals & clinics, diagnostic laboratories, research institutes, and others.

Request Free Sample Copy @ https://www.marketresearchfuture.com/sample_request/6900

Prominent Players

The prominent vendors within the worldwide chronic lymphocytic leukemia treatment market include Teva Pharmaceutical Industries Ltd., Novartis AG, AstraZeneca, Genmab A/S, TG Therapeutics, Inc., Ziopharm Oncology, F. Hoffmann-La Roche Ltd, AbbVie Inc., Genentech, Inc., Gilead, Genzyme Corporation, ONO PHARMACEUTICAL CO., LTD., GlaxoSmithKline plc, CELGENE CORPORATION, Inc., Johnson & Johnson Services, Inc., and others.

Regional Insight

The chronic lymphocytic leukemia treatment market is set to expand in the region of Europe, Asia Pacific, America, and the Middle East & Africa during the assessment period.

Following a meticulous analysis of the global trends, the Americas has been identified as the leading region in the chronic lymphocytic leukemia treatment market. The increasing prevalence of leukemia, as well as the presence of prominent vendors within the region, are the main factors responsible for the strong performance of the market. In 2018, a report published by the Leukemia & Lymphoma Society stated that every 3 minutes, an individual in the United States (US) gets diagnosed with blood cancer or leukemia.

Europe has managed to seize the second largest share of the global chronic lymphocytic leukemia treatment market. Sound healthcare infrastructure, massive healthcare spending, high awareness levels with regard to relapse of Chronic Lymphocytic Leukemia (CLL) as well as related treatments, availability of reimbursement policies, use of advanced healthcare tools and the growing adoption rate of latest techniques in practice are few lucrative factors steering the CLL treatment market towards greater heights.

With the hike in the research and development activities and the presence of profitable small markets like India, Japan, China, Australia, Republic of Korea, the Asia Pacific market is expected to expand further in the subsequent years. The region is also predicted to grow at the fastest rate, backed by factors like the growing prevalence of leukemia combined with the consequently surging demand for treatment of CLL in the region. The 2017 report furnished by the World Health Organization (WHO) suggests that at least 8,904 leukemia deaths have been reported in Japan that year, indicating the rising number of cases within the region.

The most abysmal performance has been showcased by the Middle East & Africa, having managed to acquire the least share of the worldwide market. However, the lukewarm growth of the market points towards better prospects in the future, owing to the expanding healthcare infrastructure.

Industry Developments

May 2019: Venetoclax (Venclexta, AbbVie, and Genentech) along with Obinutuzumab (Gazyva, Genentech) has been granted FDA approval for untreated chronic lymphocytic leukemia (CLL). Venclexta, as well as Gazyva, is considered to be the only chemotherapy-free option for providing favorable responses to aid the patients in living longer and curbing the progression of CLL as well.

Table Of Contents:

Chapter 1. Report Prologue

Chapter 2. Market Introduction

2.1 Definition

2.2 Scope Of The Study

2.2.1 Research Objective

2.2.2 Assumptions

2.2.3 Limitations

Chapter 3. Research Methodology

3.1 Introduction

3.2 Primary Research

3.3 Secondary Research

3.4 Market Size Estimation

Chapter 4. Market Dynamics

4.1 Drivers

4.2 Restraints

4.3 Opportunities

4.4 Challenges

4.5 Macroeconomic Indicators

4.6 Equipment Trends & Assessment

Chapter 5. Market Factor Analysis

5.1 Porter’s Five Forces Analysis

5.1.1 Bargaining Power Of Suppliers

5.1.2 Bargaining Power Of Buyers

5.1.3 Threat Of New Entrants

5.1.4 Threat Of Substitutes

5.1.5 Intensity Of Rivalry

5.2 Value Chain Analysis

5.3 Investment Feasibility Analysis

5.4 Pricing Analysis

Browse Detailed TOC with COVID-19 Impact Analysis at: https://www.marketresearchfuture.com/reports/chronic-lymphocytic-leukemia-treatment-market-6900

About Market Research Future:

At Market Research Future (MRFR), we enable our customers to unravel the complexity of various industries through our Cooked Research Report (CRR), Half-Cooked Research Reports (HCRR), & Consulting Services. MRFR team have supreme objective to provide the optimum quality market research and intelligence services to our clients.

Related Report:

Oxygen Therapy Equipment Market Research Report - Forecast to 2023

Contact:

Akash Anand

Market Research Future

+1 646 845 9312

Email: [email protected]

#Chronic Lymphocytic Leukemia Treatment

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ptmasterguide · 3 years

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Obinutuzumab

In this article, we will discuss about Obinutuzumab (Dosage Overview). So, let’s get started. Obinutuzumab (GAZYVA) is a CD20-directed cytolytic antibody and isindicated:• in combination with chlorambucil, for the treatment of patients withpreviously untreated chronic lymphocytic leukemia.• in combination with bendamustine followed by Obinutuzumab (GAZYVA) monotherapy, for the treatment of…

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#Anticancer Drugs #Medicine #Obinutuzumab #Oncology #Pharmacology #Physiotherapy

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market-research-future · 3 years

Text

Chronic Lymphocytic Leukemia Treatment Market Size, Type and Application Till 2027

Market Scenario

As per the data experts at Market Research Future (MRFR), the chronic lymphocytic leukemia treatment market was worth USD 7.9 Billion in 2017. Additionally, the market is expected to expand at a growth rate of 19% over the forecast period (2018-2023).

Market Drivers and Key Challenges

Chronic lymphocytic leukemia is considered to be one of the most common types of leukemia in adults. This type of cancer involves the development of lymphocytes, which are white blood cells, within the bone marrow. The lymphocytic leukemia cells are generally present in the lymph nodes along with various other tissues. There are two primary types of chronic lymphocytic leukemia, wherein one grows slowly, and the other is considered fatal. In general, one does not experience any symptoms due to chronic lymphocytic leukemia for a long period. However, the symptoms usually noted include fatigue, easy bruising, and swollen lymph nodes.

Generally, the most popular form of treatment for CLL is chemotherapy, whereas stem-cell transplant is for rare cases. An article published by Apollo Hospitals states that in India, roughly one million cases of chronic lymphocytic leukemia are diagnosed annually. As per the cancer statistics, 1 in every 155 men and 1 in every 260 women get affected with CLL in their lifetime, in the United Kingdom (U.K). The boost in cancer cases around the world, innovations in drug therapy, quick regulatory approval processes, and vigorous pipeline of drugs for chronic lymphocytic leukemia treatment are additional factors substantiating the growth of the chronic lymphocytic leukemia market.

Having said that, the stunted level of awareness with regard to symptoms is expected to retard the market growth in the forthcoming years. However, growing research & development activities coupled with continuous technological developments in the field is presumed to augment the market growth to a large extent.

Market Segmentation

The global chronic lymphocytic leukemia treatment market has been segmented on the basis of type, treatment, and end user.

The market, in terms of the type, has been considered for indolent CLL and aggressive CLL.

The market, treatment-wise, can be broken down into chemotherapy, targeted drug therapy, immunotherapy, and bone marrow transplant.

The end users in the global market are hospitals & clinics, diagnostic laboratories, research institutes, and others.

Browse Full Report Details @ https://www.marketresearchfuture.com/reports/chronic-lymphocytic-leukemia-treatment-market-6900

Prominent Players

The prominent vendors within the worldwide chronic lymphocytic leukemia treatment market include Teva Pharmaceutical Industries Ltd., Novartis AG, AstraZeneca, Genmab A/S, TG Therapeutics, Inc., Ziopharm Oncology, F. Hoffmann-La Roche Ltd, AbbVie Inc., Genentech, Inc., Gilead, Genzyme Corporation, ONO PHARMACEUTICAL CO., LTD., GlaxoSmithKline plc, CELGENE CORPORATION, Inc., Johnson & Johnson Services, Inc., and others.

Regional Insight

The chronic lymphocytic leukemia treatment market is set to expand in the region of Europe, Asia Pacific, America, and the Middle East & Africa during the assessment period.

Following a meticulous analysis of the global trends, the Americas has been identified as the leading region in the chronic lymphocytic leukemia treatment market. The increasing prevalence of leukemia, as well as the presence of prominent vendors within the region, are the main factors responsible for the strong performance of the market. In 2018, a report published by the Leukemia & Lymphoma Society stated that every 3 minutes, an individual in the United States (US) gets diagnosed with blood cancer or leukemia.

Europe has managed to seize the second largest share of the global chronic lymphocytic leukemia treatment market. Sound healthcare infrastructure, massive healthcare spending, high awareness levels with regard to relapse of Chronic Lymphocytic Leukemia (CLL) as well as related treatments, availability of reimbursement policies, use of advanced healthcare tools and the growing adoption rate of latest techniques in practice are few lucrative factors steering the CLL treatment market towards greater heights.

With the hike in the research and development activities and the presence of profitable small markets like India, Japan, China, Australia, Republic of Korea, the Asia Pacific market is expected to expand further in the subsequent years. The region is also predicted to grow at the fastest rate, backed by factors like the growing prevalence of leukemia combined with the consequently surging demand for treatment of CLL in the region. The 2017 report furnished by the World Health Organization (WHO) suggests that at least 8,904 leukemia deaths have been reported in Japan that year, indicating the rising number of cases within the region.

The most abysmal performance has been showcased by the Middle East & Africa, having managed to acquire the least share of the worldwide market. However, the lukewarm growth of the market points towards better prospects in the future, owing to the expanding healthcare infrastructure.

Industry Developments

May 2019: Venetoclax (Venclexta, AbbVie, and Genentech) along with Obinutuzumab (Gazyva, Genentech) has been granted FDA approval for untreated chronic lymphocytic leukemia (CLL). Venclexta, as well as Gazyva, is considered to be the only chemotherapy-free option for providing favorable responses to aid the patients in living longer and curbing the progression of CLL as well.

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orbemnews · 3 years

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Vaccines Won’t Protect Millions of Patients With Weakened Immune Systems For more than a year, Dr. Andrew Wollowitz has mostly been cloistered inside his home in Mamaroneck, N.Y. As chief of emergency medicine at Montefiore Medical Center in the Bronx, Dr. Wollowitz, 63, was eager to help treat patients when the coronavirus began raging through the city last spring. But a cancer treatment in 2019 had obliterated his immune cells, leaving him defenseless against the virus, so he instead arranged to manage his staff via Zoom. A year later, people in Dr. Wollowitz’s life are returning to some semblance of normalcy. His wife, a dancer and choreographer, is preparing to travel for work at Austria’s National Ballet Company. His vaccinated friends are getting together, but he sees them only when the weather is nice enough to sit in his backyard. “I spend very little time in public areas,” he said. Like his friends, Dr. Wollowitz was vaccinated in January. But he did not produce any antibodies in response — nor did he expect to. He is one of millions of Americans who are immunocompromised, whose bodies cannot learn to deploy immune fighters against the virus. Some immunocompromised people were born with absent or faulty immune systems, while others, like Dr. Wollowitz, have diseases or have received therapies that wiped out their immune defenses. Many of them produce few to no antibodies in response to a vaccine or an infection, leaving them susceptible to the virus. When they do become infected, they may suffer prolonged illness, with death rates as high as 55 percent. Most people who have lived with immune deficiencies for a long time are likely to be aware of their vulnerability. But others have no idea that medications may have put them at risk. “They’ll be walking around outside thinking they’re protected — but maybe they’re not,” said Dr. Lee Greenberger, chief scientific officer of the Leukemia and Lymphoma Society, which funds research on blood cancers. The only recourse for these patients — apart from sheltering in place until the virus has retreated — may be to receive regular infusions of monoclonal antibodies, which are mass-produced copies of antibodies obtained from people who have recovered from Covid-19. The Food and Drug Administration has authorized several monoclonal antibody treatments for Covid-19, but now some are also being tested to prevent infections. Convalescent plasma or gamma globulin — antibodies distilled from the blood of healthy donors — may also help immunocompromised people, although a version of the latter that includes antibodies to the coronavirus is still months from availability. “It’s a clear area of unmet need,” said Hala Mirza, a spokeswoman for Regeneron, which has provided its monoclonal antibody cocktail to a handful of immunocompromised patients through a compassionate use program. (Regeneron released trial results this week showing that the cocktail reduces symptomatic infections by 81 percent in people with normal immune systems.) It’s unclear how many immunocompromised people don’t respond to coronavirus vaccines. But the list seems at least to include survivors of blood cancers, organ transplant recipients, and anyone who takes the widely used drug Rituxan, or the cancer drugs Gazyva or Imbruvica — all of which kill or block B cells, the immune cells that churn out antibodies — or Remicade, a popular drug for treating inflammatory bowel disease. It may also include some people over age 80 whose immune responses have faltered with age. “We’re extremely concerned and interested in trying to see how we might be able to help those particular patients,” said Dr. Elad Sharon, an immunotherapy expert at the National Cancer Institute. As the pandemic spread, doctors who specialize in treating blood cancers or who care for immunocompromised people expected at least some of their patients to encounter difficulties. Dr. Charlotte Cunningham-Rundles, an immunologist at Icahn School of Medicine at Mount Sinai in New York, has about 600 patients who are almost entirely dependent on getting regular doses of gamma globulin to stay safe from pathogens. Even so, 44 of her patients became infected with the coronavirus; four died, and another four or five had long-term illnesses. (Chronic infections may offer opportunities for the virus to evolve into dangerous variants.) Steven Lotito, 56, one of Dr. Cunningham-Rundles’ patients, was diagnosed with a condition called common variable immune deficiency when he was 13. Before the pandemic, he had an active lifestyle, exercised and ate well. “I’ve always known to take sort of special care of my body,” he said. That included infusions of gamma globulin every three weeks. Despite taking careful precautions, Mr. Lotito caught the virus from his daughter in mid-October. He had a fever for nearly a month, and spent a week in the hospital. Convalescent plasma and remdesivir, an anti-viral drug, provided relief for a couple of weeks, but his fever returned. He finally felt better after one more infusion of gamma globulin, during which he sweated through four shirts. Updated April 15, 2021, 4:49 p.m. ET Still, after nearly seven weeks of illness, Mr. Lotito had no antibodies to show for it. “I still have to take the same precautions that I was taking, you know, a year ago,” he said. “It’s a little disheartening.” People like Mr. Lotito depend on those around them choosing to be vaccinated to keep the virus at bay, Dr. Cunningham-Rundles said. “You’re hoping that your entire family members and all your close colleagues are going to go out and get some shot, and they’re going to be protecting you with herd immunity,” she said. “That’s what you have to start with.” Dr. Cunningham-Rundles has tested her patients for antibodies and signed a few up for Regeneron’s monoclonal antibody cocktail. But many other people with such conditions are not aware of their risks or their options for treatment. The Leukemia and Lymphoma Society has set up a registry to provide information and antibody tests to people with blood cancers. And several studies are assessing the response to coronavirus vaccines in people with cancer, autoimmune conditions like lupus or rheumatoid arthritis, or who take drugs that mute the immune response. What You Need to Know About the Johnson & Johnson Vaccine Pause in the U.S. On April 13, 2021, U.S. health agencies called for an immediate pause in the use of Johnson & Johnson’s single-dose Covid-19 vaccine after six recipients in the United States developed a rare disorder involving blood clots within one to three weeks of vaccination. All 50 states, Washington, D.C. and Puerto Rico temporarily halted or recommended providers pause the use of the vaccine. The U.S. military, federally run vaccination sites and a host of private companies, including CVS, Walgreens, Rite Aid, Walmart and Publix, also paused the injections. Fewer than one in a million Johnson & Johnson vaccinations are now under investigation. If there is indeed a risk of blood clots from the vaccine — which has yet to be determined — that risk is extremely low. The risk of getting Covid-19 in the United States is far higher. The pause could complicate the nation’s vaccination efforts at a time when many states are confronting a surge in new cases and seeking to address vaccine hesitancy. Johnson & Johnson has also decided to delay the rollout of its vaccine in Europe amid concerns over rare blood clots, dealing another blow to Europe’s inoculation push. South Africa, devastated by a more contagious virus variant that emerged there, suspended use of the vaccine as well. Australia announced it would not purchase any doses. In one such study, British researchers followed nearly 7,000 people with Crohn’s disease or ulcerative colitis from 90 hospitals in the country. They found that less than half of patients who took Remicade mounted an immune response following coronavirus infection. In a follow-up, the scientists found that 34 percent of people taking the drug were protected after a single dose of the Pfizer vaccine and only 27 percent after a single dose of the AstraZeneca vaccine. (In Britain, the current practice is to delay second doses to stretch vaccine availability.) Likewise, another study published last month indicated that fewer than 15 percent of patients with cancers of blood or the immune system, and fewer than 40 percent of those with solid tumors, produced antibodies after receiving a single dose of the Pfizer-BioNTech vaccine. And a study published last month in the journal JAMA reported that only 17 percent of 436 transplant recipients who got one dose of the Pfizer-BioNTech or Moderna vaccine had detectable antibodies three weeks later. Despite the low odds, immunocompromised people should still get the vaccines because they may produce some immune cells that are protective, even antibodies in a subset of patients. “These patients should probably be prioritized for optimally timed two doses,” said Dr. Tariq Ahmad, a gastroenterologist at the Royal Devon and Exeter NHS Foundation Trust who was involved in the infliximab studies. He suggested that clinicians routinely measure antibody responses in immunocompromised people even after two vaccine doses, so as to identify those who also may need monoclonal antibodies to prevent infection or a third dose of the vaccines. Wendy Halperin, 54, was diagnosed at age 28 with a condition called common variable immunodeficiency. She was hospitalized with Covid-19 in January and remained there for 15 days. But the coronavirus induced unusual symptoms. “I was having trouble walking,” she recalled. “I just lost control of my limbs, like I couldn’t walk down the street.” Because she was treated for Covid-19 with convalescent plasma, Ms. Halperin has had to wait three months to be immunized and has made an appointment for April 26. But despite her condition, her body did manage to produce some antibodies to the initial infection. “The take home message is that everybody should try and get the vaccine,” said Dr. Amit Verma, an oncologist at Montefiore Medical Center. The gamble did not pay off in Dr. Wollowitz’s case. Without antibodies in his system to protect him, he is still working from home — a privilege he is grateful for. He was an avid mountain biker and advanced skier, both of which carry risk of injury, but with the coronavirus, he is playing it safe. In anticipation of returning to his normal lifestyle, Dr. Wollowitz is tuning his bicycles. But he said he foresaw himself living this way till enough other people are vaccinated and the number of infections in the city drops. “I’m not exactly sure what that date is,” he said. “I’m really waiting to get back out.” Source link Orbem News #immune #Millions #patients #protect #systems #Vaccines #Weakened #Wont

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kunalcmi · 4 years

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FC PROTEIN & GLYCOENGINEERED ANTIBODIES MARKET ANALYSIS - (2019-2027)

Monoclonal antibodies are developed by identical immune cells, which have a therapeutic use. The crystallized fragments (Fc) protein and glycoengineered antibodies are known as the next generation antibodies. These monoclonal antibodies are immunoglobulin G (IgG) type of molecules, which are attached to a glycan residue on crystallisable fragment. Glycoengineering is the method by which these antibodies are created. They have varied applications for the treatment of diseases such as multiple sclerosis and cancers.