#Frederick R Prete
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By: Frederick R. Prete
Published: Feb 11, 2024
About the Author
Frederick Prete is a biopsychologist in the Dept. of Biology at Northeastern Illinois University. He teaches courses in neurobiology, and human and animal physiology. He has also served as an associate editor for the International Journal of Comparative Psychology. Prete writes about how people use and misuse biology to support their social and political points of view. 
Other essays by Prete can be found on his Substack Everything Is Biology.
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The contemporary “debate” (if one can call it that) surrounding the biology of sex suffers from a lack of intellectual seriousness on one side. The arguments forwarded by those insisting on the non-binary nature of sex often demonstrate a rudimentary understanding of basic biology, or are so comically nonsensical that one wonders whether they’re even worth responding to. Academic biologists engaging with gender activists’ arguments for the so-called “sex spectrum” are like mathematicians engaging with numerologists (individuals who believe in a mystical relationship between numbers and coinciding events) or geologists debating Flat Earthers. However, given that sex pseudoscience has somehow taken over academia, serious scholars now find themselves compelled to engage with the absurd.
One such example is the bizarre suggestion that because some fish can literally change sex during their lifetime, then perhaps humans can too. This idea, while absurd on its face, is far from fringe. It has been given credence by popular science outlets like Scientific American, which highlighted the sex-changing abilities of clown fish “to emphasize the diversity of ways in which sexual beings move through the world.” Even the United Kingdom’s national library posted (and later deleted) a thread on X during Pride Month last year about the sex-changing abilities of the Māori wrasse, and Greenpeace made a similar move in 2021.
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What relevance does LGBTQ+ Pride Month have to sex-changing fish unless there’s an intention to suggest that these examples illuminate the potential for sex changes in humans? But if activists insist on making such far-fetched comparisons, they should be challenged to follow their logic to its ultimate conclusion.
Let’s be honest, animals do a lot of weird things. They enslave other animals, eat their offspring, cannibalize their lovers, kill their newborn twin sisters, and devour their siblings in the womb. Do any of these activists want to justify slavery or embryonic cannibalism because animals do it? Probably not. But it’s equally silly to claim that we can derive grand lessons about human biology and sexual behavior from animals. Male octopuses, for instance, grab a packet of their own sperm with one of their tentacles, shove inside a female’s mantle cavity, and drop it next to her oviduct. This hardly seems like a behavior humans should try to emulate. Are there any objections? Why, then, would we think that fish sexual biology is a better model for us humans than that of octopuses?
What’s more, it frustrates me that those who continuously discuss sex changes in fish don’t get the fish-sex story straight in the first place. In reality, sex changes among the roughly 20 families and seven orders of teleost fish are driven by physiological and hormonal events that are triggered—depending on the species—by factors such as body size, perceived social status, or (in the monogamous clown fish Amphiprioninae) the disappearance of the large, breeding female. It’s also the case that those big, newly minted, dominant female clown fish are viciously aggressive to any fish they do not recognize as part of their group. So, if we’re taking our cues from clown fish, let’s not be hypocritical—let’s go all the way and demand that only extremely large, dominant, hyper-monogamous people who are particularly xenophobic should consider a sex change, and only after all the other females in the neighborhood have vanished. Does that sound reasonable? (I trust you realize I am being facetious here)
It should go without saying, but it appears that some still need a reminder: people are not fish. Fish live in the water. People live on land. When it comes to sex and reproduction, this makes all the difference in the world. In aquatic environments, you can simply release your gametes (eggs and sperm) into the water and let them drift around until they hook up. That’s because, in water, they won’t dry out and die. And neither will your embryos because they’ll be in the water, too. This is why so many fish can produce eggs or sperm at different times in their lives. It doesn’t take any specialized external organs to squirt gametes into the water, just a gonad for gamete production and an orifice for release.
However, the whole situation changes if you live on dry land. As mammals evolved for terrestrial life, they had to acquire adaptations—both structural and behavioral—to prevent their gametes and embryos from drying out. You can’t simply drop your sperms and eggs on the ground and hope for the best. So, male terrestrial animals evolved specialized external body parts for transferring sperm directly into females, who, in turn, have evolved body parts designed for receiving sperm and a chamber for nurturing the developing embryo until it is ready for life on dry land. Additionally��and equally important—both males and females evolved complementary neuromuscular behavioral patterns that allow them to court and mate successfully.
That’s why terrestrial mammals can’t change sex like some fish do. Such a transformation would require females to spontaneously sprout some kind of tube for internal sperm delivery, and males would need to somehow develop a complementary orifice. Moreover—and more importantly—both males and females would need to develop all the necessary internal parts and “plumbing” to make these external structures functional. It’s insufficient to merely alter the appearance of external structures, which can be done surgically (even on pets). A terrestrial animal transitioning from a female to a male would also require developing a complex duct system linking the gonads to the external tube, along with glands to secrete a carrying fluid and nutrients for the sperm (i.e., the Wolffian duct system, prostate, and bulbourethral glands). Going from male to female would involve developing some kind of organ to catch the eggs when they get released into the abdominal cavity, retain them until they encounter sperm, and then house the resulting embryo while it develops (these are derivatives of the Müllerian duct system).
Obviously, none of this could happen. When it comes to mammals, the die is cast prenatally. So, whatever fish do is their business and has absolutely nothing to do with terrestrial mammals. So, let’s drop the clown fish and Asian sheepshead wrasse analogies. Anybody who brings them up simply doesn’t understand evolutionary biology. It is futile to engage in discussions based on such analogies unless, of course, you’re one of those people who think that because some animals reproduce parthenogenically, humans should simply stop having sex altogether and hope for the best.
I want to make it clear that I have a deep understanding and empathy for those of us, including myself, who do not fit the popular stereotypes of any category or group. Throughout my life, I have received what seems to be an unrelenting stream of criticism for the fact that I was never (and still am not) perceived as representative of the norm (whatever that is). Consequently, I grew up defending those who were similarly targeted, and I believe that each of us should be continually mindful and accepting of the rich diversity of the human condition. Each of us should actively and consciously strive to be as compassionate, accepting, supportive, and inclusive as possible.
However, doing so does not require us to abandon reason, turn our backs on biology, or unhinge ourselves from reality.
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By: Frederick R. Prete
Published: Mar 1, 2024
A few weeks ago, I wrote a piece that appeared on the Substack, Reality’s Last Stand. My intent was to compliment and complement Dr. Wright’s critique of Ian Copeland’s (erroneous) claim that biological sex (which is different from “gender”) is non-binary. Copeland’s somewhat tired arguments were based on a misunderstanding of genetic aneuploidies (errors in chromosome number), and poorly reasoned analogies to the fact that some fish change sex over the course of their lives. I’d like to revisit and expand a few of my points here.
As usual, Wright’s analysis was thoughtful and accurate. However, I wondered out loud how much of this long-suffering debate is shorn up by repeated attempts to engage in it with evermore biologically detailed counter arguments — a thankless task in which I, too, have participated. Although I have the utmost respect for those with the patience to remain in the argumentative fray, I don’t think reason will ever change what is, in effect, an ideological point of view. But, again, I admire those who try.
As I said in the piece, we need to recognize that some arguments are just wrong. So wrong, in fact, that a reasoned rebuttal is not only futile but beside the point. In those instances, we should be honest. I know from decades of teaching that sometimes I have to say to a student — always in a kind and respectful way — that while I appreciate their point of view, it is simply mistaken… It doesn’t jibe with anything that I know about the natural world. In such instances, this is the most honest and effective response, and it allows the discussion to be reset on a more reasonable foundation.
To be clear, even very smart, well-meaning people come up with far-fetched ideas born out of fundamental misunderstandings, or ignorance about a particular topic. (That would be the case, for instance, if I tried to diagnose what’s wrong with your car, a topic about which I know absolutely nothing.) In these instances, it makes little sense to debate the erroneous argument and then rebut the person’s attempts to support their misconceptions with additional unfounded speculations (often ad infinitum). So, if I claim that an animal’s sex is determined by radio waves beamed down from the planet Zenon by unicorns, it would be a waste of your time to explain to me that unicorns couldn’t make radio transmitters with their little hoofs, or that Zenon (wherever it is) is too far away to communicate with us earthlings. If you did offer up this rebuttal, I’d simply come up with some counter argument about unicorn dexterity or the superior strength of unicorn radio technology. That would be a total waste of our time. At some level, I suppose, it’s also disingenuous to pretend that the unicorn argument merits a reasoned response. I think it would be more honest (and effective) just to dismiss the unicorn theory out of hand rather than fueling — and thereby giving credence to — an unending back-and-forth.
That’s how I feel about the recurring claims that disorders of sexual development (DSDs), or genetic aneuploidies represent unique sexes. Frankly, these claims are so discordant with the realities of biology that they will never be refuted successfully by logic, reason, or data. To argue that biological anomalies represent unique sex categories makes no more sense than claiming a syndrome such as CDC (which can result in penile duplication) gives rise to ‘new types’ of men. These arguments are simply wrong. End of conversation.
And, please, just ignore those ridiculous — but supposedly instructive — analogies to animals. Let’s be honest. Animals do a lot of weird things. They enslave other animals, eat their offspring, cannibalize their lovers, kill their newborn twin sisters, and devour their siblings in the womb. Does anyone want to justify slavery or sibling cannibalism because animals do it?
And, how about those strange animal mating behaviors? Consider the male argonaut (a genus of octopus). He grows a sperm carrying third left arm in a pouch under his eye which — when he’s ready for love — explodes out of its sheath, detaches from his face, swims away all by itself, latches onto a female, and then wriggles its way into her mantle cavity to drop off a packet of sperm. Do you think we humans should invent a face-mounted, free-flying phallus to enhance our love-life? After all, it works for the argonaut. (By the way, I don’t think you should add that suggestion to your online dating profile.)
Well, If a free-flying phallus doesn’t seem like a good idea, why would anyone think that the sexual behaviors of other aquatic animals — like sex-changing clown fish — reveal some profound philosophical insights into the human condition?
Even more exasperating is the fact that the people who keep harping on sex-changing fish never get the story straight. The truth is that the sex changes that occur in about 20 families and seven orders of fish are the result of neuro-physiological and hormonal events triggered — depending upon the species — by ultimate body size, perceived social status, or (in the monogamous clown fish, Amphiprioninae) after the big breeding female has disappeared. In addition, the large, dominant, newly-minted female is viciously aggressive to any fish outside of her immediate family. So, if we’re taking our cues from clown fish, let’s not be hypocrites. Let’s go all the way: Only really large, domineering, hyper-monogamous humans who are particularly xenophobic should consider changing sex, but only after all the females in the neighborhood disappear. Does that even make sense? (You know I’m being facetious, right?) It’s a silly analogy. Is it worth debating?
In the previous essay, I also brought up an obvious (but consistently ignored) point of fact: Fish live in the water. People live on land. This makes all the difference in the world when it comes to sex. If you live in water, you can spray your eggs and sperm (gametes) into the liquid environment and let them drift around until they hook up. That’s because, in water, they won’t dry out and die. And, neither will the resulting embryos because they’ll be in the water, too. That’s why some fish can produce eggs or sperm at different times in their lives. It doesn’t take any special external body parts to squirt gametes into water. All you need is a gonad to make the gametes and an orifice to let them out.
However, if you’re a terrestrial mammal (living on dry land), you have a problem. You can’t squirt your gametes on the ground and hope for the best. They’ll shrivel up and die. So, male terrestrial animals evolved special external body parts with which to insert sperm directly into females (where it’s warm and moist), and females evolved body parts designed to accept that protuberance. In addition, female mammals (except for a few monotremes) evolved a chamber in which to hold the developing embryo until it’s ready to face a potentially desiccating life on land. Equally important, both males and females evolved complementary behavioral patterns that allow them to court and mate successfully. Frankly, it doesn’t make any difference if you’ve got the external body parts but you don’t know how to use them. (Get my drift?)
That’s why terrestrial mammals can’t change sex like fish. Doing so would require females to magically sprout some kind of tube to deliver sperm internally, and males would have to spontaneously develop a complementary orifice. In addition — and more importantly — males and females would have to develop all the necessary internal ‘plumbing’ and mating behaviors necessary to operate their new equipment. So, a mammalian sex change requires more than altering the external structures. That’s the easy part. It can be done surgically, even on your pets.
Becoming a male terrestrial animal would require developing a complex duct system linking the gonads to that new, external tube, and internal glands to secrete a carrying fluid and nutrients for the sperm (i.e., the Wolffian duct system, prostate, and bulbourethral glands). Becoming a female would require developing some kind of internal tube that would catch the eggs when they’re released into the abdominal cavity, hold them until they meet some sperm, and house the developing embryo (i.e., the derivatives of the Müllerian duct system).
Obviously, none of this could happen. When it comes to mammals, the die is cast prenatally. In other words, whatever fish do is their business. It has no grand implications for terrestrial mammals. So, let’s drop the clown fish and Asian sheepshead wrasse analogies. Anybody who brings them up simply doesn’t understand evolutionary or developmental biology. It’s not worth the debate unless, of course, you’re one of those people who thinks that because some animals are parthenogenic, we should simply stop having sex altogether and hope for the best.
I also want to clear up two more points. The first is sort of minor. It has to do with the large gamete/small gamete dichotomy between male and female animals: Females produce large gametes; males produce small gametes. This is frequently cited as evidence that there are just two sexes, easily differentiated by gamete size. Although generally true, I want to point out (yet again) that there are always exceptions in biology. Unfortunately, those exceptions are often the fuel that ignites these recalcitrant debates about sex when someone ‘discovers’ the exception and then claims it to be a new, profound revelation upending all prior knowledge. The odd exception to which I’m referring here is the colossal size of the fruit fly sperm. You probably didn’t know — few people do — that the tiny fruit fly, Drosophila bifurca, produces sperm that are 58 mm (~2.25 inches) long. That’s about 20 times longer than its entire body and over 300 times longer than a female’s egg is wide. In fact, these sperm are thought to be the longest sperm of any animal on the planet. So, I’m sure that at some point, someone will use this fact to argue against the large gamete/small gamete dichotomy between the sexes. It will be a silly argument, of course. I just want you to be forewarned.
The second point has to do with reptile sex determination. I have heard this phenomenon described inaccurately by people on both sides of the sex binary debate. It comes up almost as frequently as the clown fish analogy. Frankly, it’s a bit misleading to the lay reader to say that turtle (or alligator) sex is ‘determined’ by temperature. Although this is the common way it’s phrased in the biological literature, it should be made clear that sexual development in reptiles and amphibians is a product of the same types of genetic and physiological processes that operate in other animals. Saying that reptile sex is ‘determined’ by temperature makes it sound like the whole process is much more capricious than it is. While “a narrow range of incubation temperatures during a thermosensitive period of embryonic development” can affect the underlying genetic, physiological, and biochemical processes in ways that alter the sex ratios (i.e., the relative numbers of males and females) in a cohort, the most proximate causes leading to a turtle or alligator being male or female are physiological. In the end, it’s all genes, hormones, and molecules just like it is in other animals. And, the ultimate developmental outcome is binary.
The take-home message
So, here’s the upshot: You should just be you… and I’ll just be Frederick. We don’t need to ask flies, fish, or turtles for permission to be what we are, or what we hope to be… they’ve got their own problems to deal with. Capisci?
Epilogue
As I said in the previous essay, I have a deep understanding of, and great compassion for those people — which includes me — who don’t match the accepted stereotypes of any particular category or group. Over the years, I have been the target of what seemed to be an unrelenting stream of criticism for the fact that I was never (and still am not) perceived as representative of the norm (whatever that is). Consequently, I grew up defending those who were similarly targeted, and I believe that each of us should be continually mindful and accepting of the rich diversity of the human condition. Each of us should actively and consciously strive to be as compassionate, accepting, supportive and inclusive as we can. Denigrating, harassing or bullying anyone for any reason is reprehensible and unacceptable as far as I am concerned.
However, being open, kind, and accepting does not necessitate abandoning reason, turning our backs on biology, or unhinging ourselves from reality. Nor does it require us to entertain the arguments of those who do.
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By: Frederick R. Prete
Published: Apr 18, 2023
In a recent article for FAIR Substack, David Ferrero argued convincingly that school programs designed to view their subject matter through an “ethnic studies”— rather than an “ethnic histories”— lens can be “reductive, tendentious, divisive, and doctrinaire.” He also pointed out that this narrow approach, which includes indiscriminate references to putative ‘racial’ groups (“black”, “Asian”, “white”, etc.), is antithetical to the ideal of bridging our “ethnic and religious differences in the service of forging a shared civic identity.”
While I am in complete agreement with Ferrero, I would go even further. I believe that there is a fundamental conceptual flaw in using current racial categories in any academic analysis. These categories have become so hopelessly ambiguous that they are virtually meaningless, and they now function as terms of convenience, used only when they serve a political agenda. This is true throughout academia, but is most evident in discussions about academic achievement.
In biology, “race” is a taxonomic term, and like all biological terms, it can be ambiguous. Sometimes it’s used as a synonym for subspecies. Most often, however, it refers to a group of organisms that is biologically or geographically distinguishable from other groups within a species but is still able to reproduce with them. 
On the other hand, when referring to humans, most contemporary scientists consider ‘race’ a social construct based on societal definitions without any inherent physical or biological meaning. That point of view is based on the understanding that there is more genetic variability within human racial groups than between them. In other words — to paraphrase the evolutionary biologist Richard Dawkins — whereas human sex is binary (there are only two), race is a spectrum.
Ironically, despite the fact that most academics consider human racial categories to be socially constructed, they continue to use them enthusiastically as if they represented well-defined, homogeneous groups of people. Think of the controversies over college admissions, disparities in academic achievement, or ethnic studies curricula.
The problems with grouping students in terms of contemporary racial categories are most evident — and most instructive — in how we interpret their academic performance, especially on standardized tests like the ACT. I’ve argued (here, here, and here) that racial categories are virtually useless in explaining student performance differences because the categories are largely arbitrary, often contrived, and always confounded by self-reporting biases and socio-economics. Nonetheless, a race-based narrative continues to dominate our discussions despite the fact that thinking in those terms perpetuates a host of inaccurate, deleterious stereotypes.
The ACT is a standardized test that predicts the likelihood of student success in the first year of college. The overall score is based on the results of four, multiple-choice subject tests, English, math, reading, and science. The number of correct answers for each subject test is converted into a scaled score and averaged. Thirty-six is perfect.
In 2022, approximately 1.35 million students took the ACT. Overall, the average score was 20, about one point lower than the average between 1990 and 2021. In terms of the ACT’s racial categories, the highest 2022 scores were earned by students identifying as Asian (25), White (21), and Two or More Races (20). The next three groups were Hispanic/Latino, Prefer Not to Respond/No Response, and Native Hawaiian/Pacific Islander (18). The two lowest-performing groups were American Indians/Alaskan Native, and Black/African-American (16).
This ranking by race has remained virtually unchanged for a decade, and when viewed in terms of these categories, the ranking seems to support the divisive and inaccurate belief that the test is racially discriminatory. However, there are two problems with viewing the scores in this way. First, it’s impossible to know exactly how students sort — or choose not to sort — themselves into racial categories, and there is no way of knowing the ethnicity of those in the Two or More Races (first introduced in 2012), or the Prefer Not to Respond groups.
Second, the categories, themselves, have always been somewhat arbitrary. For instance, in 2012, the ACT separated the so-called, Asian-American/Pacific Islander category into two cohorts that turned out to be completely different in their test performances. In that year, there was a 13% increase in the number of students in the Asian group, and a 12% decrease in the number of Pacific Islanders who met the ACT’s College Readiness Benchmarks compared to 2006. That remarkable divergence has continued. Since 2012, the Asian group’s ACT scores have steadily improved while all other groups have steadily declined. This clearly demonstrates that the original Asian-American/Pacific Islander group was a demographic of convenience with little external validity and which masked dramatic within-group differences. Further, because the two newly created groups are so diverse, it would be virtually impossible to determine precisely why the group performances are so different. Assuredly, the same thing would happen if any of the other racial categories were similarly subdivided.
Then, in 2006, the ACT began analyzing student scores in terms of Postsecondary Educational Aspiration (what students planned to do after graduation). This parameter included seven categories: Vocational-Technical Training, Two-Year College Degree, Bachelor's Degree, Graduate Study, Professional-Level Degree, and two which I won’t consider here, Other and No Response. When the data are considered in terms of these categories rather than race, a very different picture emerges.
In 2006, 2012, and 2022, across all racial groups, ACT scores were 31-51% higher for students aspiring to a professional-level degree compared to students planning on vocational-technical training, and scores were 12-17% higher for those aspiring to a graduate degree compared to a bachelor's degree.
The effects of postgraduate aspirations have been even more dramatic within racial groups every year since 2006. For instance, in 2022, students in every category who aspired to a professional-level degree had ACT scores averaging 47% higher than those planning on vocational-technical training. The largest differences — 53% and 61% — were in the Native Hawaiian/Pacific Islander and Prefer Not to Respond/No Response groups. The smallest (but still significant) difference — 35% — was in the American Indian/Alaska Native group.
More importantly, in 2022, students in the four (overall) lowest-performing racial groups who aspired to graduate study or a professional-level degree earned scores as much as 39% higher than students in the (overall) highest-performing groups who aspired to vocational-technical training or a two-year college degree. In other words, Black, American Native, Hispanic, and Hawaiian/Pacific Islander students with high educational aspirations outscored Asian, White, multiracial, and non-identifying students with lower aspirations.
Unfortunately, no one seems to have noticed that aspirations are more important than race in predicting academic performance on the test. I guess that doesn’t fit the popular narrative.
Over the past 15 years, educational aspirations have consistently had a greater impact on ACT performance than self-reported race. This suggests that by doing what we can to elevate student aspirations, irrespective of their race, we will benefit their academic performance. One way to do this is by teaching students that they can and will succeed if they work hard, rather than telling them that they are at the mercy of uncontrollable external circumstances. This will also give the lie to the worn out, race-based tropes about academic performance that are so psychologically damaging to students.
As a Biological Psychologist — and someone who taught standardized test prep for over a decade — I understand that the factors influencing student performance are complex and often the result of long-term trends that vary within and between groups, regardless of how the groups are defined. However, using anachronistic, ambiguous, or contrived racial categories to interpret educational performance is misleading, unhelpful, and divisive.
Racial categories have external validity only to the extent that each represents a meaningfully homogenous and distinct group of people. However, none of these criteria are met by the colloquial categories currently applied to people. Distinguishing students by, for instance, family or socioeconomic demographics, internalized cultural beliefs, personality traits (such as resilience or aspirations), school district, or ZIP code would all be more informative and useful in improving educational policy than the current crude racial categories. Further, to paraphrase Ferrero, refocusing our conversation on aspirations — rather than on our perceived ethnicity — will help us bridge our imagined racial differences, recognize our shared humanity, and encourage us to pursue our goals together.
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@madwriterscorner You might find this interesting.
This demonstrates the problem with univariate takes, like those of Kendi, whose entire academic output sits precariously atop the fallacy of Causal Reductionism and his complete lack of interest in understanding a problem before pretending he does.
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