#Fluvoxamine 50 mg Tablet

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First, 50 mg tablet is used in the treatment of anxiety disorders and for stress management. One of the practical uses of frext 50 mg is its active role in the treatment of depression. The drug is available both via online med websites or through the medical dispensaries located nearby. But before you purchase the medicine, it is essential that you are well aware of the side effects of Fluvoxamine. Make sure you take adequate dosage and consult your doctor beforehand for the suggested dose and guidelines. This medicine can also be used in the treatment of the obsessive-compulsive disorder.

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Fluvoxamine Maleate

Brand Name: Luvox

Generic Available

Common Dosage Forms:

Tablets: 25 mg, 50 mg, 100 mg

Capsules, Extended-Release: 100 mg, 150 mg

FDA Indications/Dosages:

Treatment of Obsessive Compulsive Disorder*

Adults: Start with 50 to 100 mg once daily at bedtime. Increase dosage as needed no sooner than weekly up to a maximum of 300 mg per day. Tablets are usually given in two separate doses and ER capsules in a single bedtime dose.

Pediatric (8-17 years of age): Start with 25 mg once daily. Increase dosage as needed no sooner than weekly up to a maximum of 200 mg per day. Daily doses over 50 mg should be given in two separate doses.

*OCD is characterized by recurrent and persistent ideas, thoughts, or images (obsessions) that are ego-dystonic and/or repetitive, purposeful, and intentional behaviors (compulsions) that are recognized by the patient as excessive or unreasonable.

Monitor: Weight in children and adolescents

Pharmacology/Pharmacokinetics: Fluvoxamine’s actions are thought to be due to an inhibition of CNS neuronal uptake of serotonin (5HT). It has no significant affinity for adrenergic, cholinergic, GABA, dopaminergic, histaminergic, benzodiazepine, or serotonergic receptors. Terminal elimination undergoes extensive first-pass metabolism (oxidative demethylation and deamination) to form less active metabolites. Excretion occurs both through the urine and through the feces. About 80% of fluvoxamine is bound to plasma proteins. It is a substrate for P450 hepatic isoenzymes CYPIA2, CYPIIC9, and CYPIIIA4.

Drug Interactions: Use in combination (within 14 days) with MONOAMINE OXIDASE INHIBITORS (MAOI) may cause serious or even fatal reactions. May increase the effects of TERFENADINE, CISAPRIDE, THEOPHYLLINE, WARFARIN, TIZANIDINE, RAMELTEON, diazepam, alprazolam, midazolam, triazolam, carbamazepine, clozapine, amitriptyline, clomipramine, imipramine, and methadone. Lithium and tryptophan may enhance its effects.

Contraindications/Precautions: Do not use within 14 days of therapy with a MAOI. Do not use with terfenadine or cisapride. INCREASED RISK OF SUICIDAL THINKING AND BEHAVIOR IN CHILDREN, ADOLESCENTS, AND YOUNG  ADULTS TAKING ANTIDEPRESSANTS FOR MAJOR DEPRESSIVE DISORDER AND OTHER PSYCHIATRIC DISORDERS. Use with caution in patients with renal or hepatic dysfunction. Patients should be careful when performing tasks which require alertness. Fluvoxamine is secreted in breast milk. Pregnancy Category C.

Adverse Effects: Nausea (40%), headache (22%), insomnia (21%), somnolence (22%), asthenia (14%), GI complaints (11%), dry mouth (14%), nervousness (12%), dizziness (11%), sweating (7%), delayed ejaculation (8%).

Patient Consultation:

Continued therapy may be needed to show noticeable improvement. Do not stop therapy before consulting with a physician.

Use caution when performing tasks that require mental alertness.

Store in a cool, dry place away from sunlight and children.

Contact a physician if the above side effects are severe or persistent.

If a dose is missed, skip it and return to normal dosing schedule.

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Fluvoxamine Side Effects Are Typical in USA

Fluvoxamine side effects come in a variety of strengths, the most common of which is 50 mg. There can be low intensity as well as high intensity. All you have to do is take the tradition that's specified for your illness. Fluvoxamine can be used for a variety of other effects that are not covered in this drug companion. Dizziness, nausea, puking, dry mouth, indigestion, loss of appetite, increased sweating, unease, and earthquake are some of the Fluvoxamine side effects. Fluvoxamine should be taken before bedtime, without eating. 

Still, you may witness unwelcome side goods ( similar to agitation, confusion, If you suddenly stop using fluvoxamine. Before you stop taking your medicine, talk to your croaker. Keep forcefully unrestricted and down from humidity and heat at room temperature. Take the capsules as soon as possible, but skip this delayed cure as your coming cure is approaching. Don't combine two tablets at formerly. Fluvoxamine can complicate this effect when combined with other anodynes. Consult your croaker previous to actually taking an antibiotic tradition, a napping medicine, a muscle relaxant, or a treatment for uneasiness or seizures.

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Fluvoxamine in Australia

Fluvoxamine is available for many countries, especially one of the more consuming countries is Australia. This drug is called Luvox in Australia, but still, it is fluvoxamine in Australia and it is a prescribed drug. It mainly treats the symptoms of OCD. Fluvoxamine in Australia is a stand-alone drug, but sometimes doctors prescribe it with other drugs. This medicine is not advisable for children younger than 8 years of age. Fluvoxamine is a selective serotonin reuptake inhibitor approved by food and drug administration. It is not only treated with obsessive-compulsive disorder, and it can be a good drug for mental depression, stress, etc. It is available in different doses like 25 mg, 50 mg, and 100 mg. For the dosage of adults not more than 300 mg and child 200 to 300 mg.

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Fluvoxamine 50 mg Tablets

Fluvoxamine 50 mg Tablets

Fluvoxamine 50 mg Tablets Antidepressants Drugs Fluvoxamine 50 mg Tablets

SUMMARY OF PRODUCT CHARACTERISTICS

1 NAME OF THE MEDICINAL PRODUCT

Fluvoxamine 50 mg Tablets

2 QUALITATIVE AND QUANTITATIVE COMPOSITION

Active ingredient: fluvoxamine maleate

Each film coated tablet contains fluvoxamine as 50 mg of fluvoxamine maleate.

For a full list of excipients see Section 6.1

3…

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Cilostazol

Brand Name: Pletal

Generic Available

Common Dosage Forms:

Tablets: 50 mg and 100 mg.

FDA Indications/Dosages:

For the reduction of symptoms of intermittent claudication as indicated by an increased walking distance: Normal dose is 100 mg twice daily, taken at least  30 minutes before or 2 hours after breakfast and dinner. A dose of 50 mg twice daily may be used in patients taking CYP3A4 or CYP2C19 inhibitors (ketoconazole, itraconazole, erythromycin, diltiazem, omeprazole). Response to therapy may begin as soon as 2 weeks following start or up to 12 weeks following start.

Pharmacology/Pharmacokinetics: Cilostazol is a quinolinone derivative that inhibits cyclic AMP phosphodiesterase III. Inhibition of this isoenzyme results in vasodilation and inhibition of platelet aggregation. Cilostazol mildly decreases serum triglycerides and rises serum high-density lipoproteins (HDL). Cilostazol also increases myocardial contractile force, coronary blood flow. and ventricular automaticity. Oral absorption is increased by high-fat meals. Steady state plasma levels are reached in 2 days. Metabolism occurs extensively by cytochrome P450 enzymes, predominantly 3A4 and to a lesser extent 2C19. Both primarily metabolites (DHC and HC) are active. 95-98% of cilostazol, 98% of DHC, and 66% of HC is protein bound, mostly to albumin. Cilostazol and its metabolites have apparent elimination half-life of 11 to 13 hours.

Drug Interactions: Diltiazem, erythromycin, ketoconazole, itraconazole, fluconazole, miconazole, fluvoxamine, fluoxetine, nefazodone, sertraline, or grapefruit juice may increase plasma levels due to inhibition of CYP3A4. Avoid concurrent use of these combinations or start cilostazol at half the recommended dose, Variable effects of both omeprazole and cilostazol can occur with concurrent use.

Contraindications/Precautions: Cilostazol is contraindicated in patients with congestive heart failure of any severity. Reported use in animal subjects has produced various cardiovascular lesions, including endocardial hemorrhage, hemosiderin deposition and fibrosis in the left ventricle, hemorrhage in the right atrial wall, hemorrhage and necrosis of the small muscle in the wall of the coronary artery, intimal thickening of the coronary artery, and coronary arteritis and periarteritis. Use with caution in nursing mothers. Pregnancy Category C.

Adverse Effects: Headache (34%), diarrhea (19%), abnormal stools (15%), palpitation (10%). nausea (10%), dizziness (10%), pharyngitis (10%), infection (10%), nausea (7%), rhinitis (7%), back pain (7%), peripheral edema (7%), dyspepsia (6%), abdominal pain (5%), tachycardia (4%), cough (4%), flatulence (4%), myalgia (3%). The percentage of incidence listed for for these adverse effects are when using a 100 mg twice daily dose.

Patient Consultation:

Noticeable improvement may take up to 12 weeks to appear.

Contact your physician if the above side effects are severe or persistent.

Contact your physician if you notice any indication of cardiovascular disease including shortness of breath, peripheral edema, or chest pain.

Take on an empty stomach, at least 30 minutes before or 2 hours after meals.

Do not drink grapefruit juice while taking this medication.

Do not exceed prescribed dosage; take medication only as directed.

Store in a cool, dry place away from sunlight and children.

If a dose is missed, take it as soon as possible. If it is closer to the time of your next dose than the dose you missed, skip the missed dose and return to dosing schedule. Do not double doses.