#Epigenetics and diabetes

[shamanflavio]

The Alarming Rise of Diabetes: A Call for Integrated Healing Approaches

In the span of a century, the prevalence of diabetes has surged from an estimated 1% to a staggering 11.6%, as reported by the CDC’s National Diabetes Report. This alarming escalation prompts a critical examination of our healthcare paradigms and the role of the American Diabetes Association (ADA), a cornerstone in diabetes research and information dissemination. Despite decades of efforts, we…

[diseaseincontext]

Understanding the Unique Challenge of Type 2 Diabetes in South Asians!

Diabetes is a recognized global health concern, affecting millions of people around the world. However, certain populations are at a higher risk, and among them, South Asians stand out. Type 2 diabetes is a significant health issue for this group, with a higher prevalence and unique genetic and environmental factors contributing to their susceptibility. In this blog post, we will explore the complex relationship between South Asians and type 2 diabetes, drawing insights from recent research studies.

The Genetic Link: Insights from KCNQ1 Variants

One of the key factors contributing to the high prevalence of type 2 diabetes in South Asians is their genetic makeup. A study by Been et al. (2011) found that specific variants in the KCNQ1 gene increase susceptibility to type 2 diabetes in South Asians. The research, which involved 3,310 subjects from India and the US, highlighted the importance of genetics in understanding the risk factors for this group.

A Systematic Overview of Genetic Studies

Chowdhury et al. (2014) conducted a systematic overview of genetic studies related to type 2 diabetes in South Asians. Their research consolidated findings from various studies, shedding light on the complex genetic factors that contribute to diabetes susceptibility in this population. The study provides a comprehensive understanding of the genetic landscape of type 2 diabetes in South Asians.

South Asian Diabetes in a Global Context

Gujral et al. (2013) examined the similarities and differences between type 2 diabetes in South Asians and other populations, including white Caucasians. The research revealed the unique challenges faced by South Asians and how their genetic and environmental contexts influence the disease. Understanding these distinctions is essential for tailoring effective diabetes prevention and management strategies. The impact of past famines in a condensed period of time (specifically induced by colonialism during the 19th and 20th centuries) can also be argued to have shaped the South Asian epigenetic framework to hold onto fat in a comparatively different manner than white Caucasian counterparts.

Exploring Underexplored Pathways

Narayan and Kanaya (2020) proposed a hypothesis to answer the critical question: "Why are South Asians prone to type 2 diabetes?" They explored underexplored pathways that might contribute to the increased risk in this population. Their hypothesis opens new avenues for research and the development of targeted interventions.

The Role of Lifestyle and Socioeconomic Factors

Type 2 diabetes is not solely a genetic issue. Unnikrishnan, Gupta, and Mohan (2018) emphasized the significance of lifestyle and socioeconomic factors in understanding the phenotype, clinical presentation, and natural history of diabetes in South Asians. This comprehensive approach takes into account the broader context in which diabetes develops in this population.

The Urgency of Action

In their 2007 article, Patel and Bhopal highlighted the diabetes epidemic in the South Asian diaspora. The piece underscores the importance of taking action to address this growing health crisis. Early interventions and awareness are crucial to preventing further escalation of diabetes in the South Asian community.

-- The high prevalence of type 2 diabetes among South Asians is a multifaceted issue influenced by genetics, lifestyle, and socioeconomic factors. Research, such as the studies mentioned in this blog post, helps shed light on the complexities of this disease in this population. By understanding the unique context of South Asians, we can develop more effective strategies for prevention and management, ultimately reducing the burden of type 2 diabetes in this at-risk group. This is a topic I'm incredibly interested in researching and will probably write more about in future posts!

References!

Been, L. F., Ralhan, S., Wander, G. S., Mehra, N. K., Singh, J., Mulvihill, J. J., Aston, C. E., & Sanghera, D. K. (2011). Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: A study of 3,310 subjects from India and the US. BMC Medical Genetics, 12(1), 18. https://doi.org/10.1186/1471-2350-12-18

Chowdhury, R., M. Venkat Narayan, K., Zabetian, A., Raj, S., & Tabassum, R. (2014). Genetic Studies of Type 2 Diabetes in South Asians: A Systematic Overview. Current Diabetes Reviews, 10(4), 258–274.

Gujral, U. P., Pradeepa, R., Weber, M. B., Narayan, K. M. V., & Mohan, V. (2013). Type 2 diabetes in South Asians: Similarities and differences with white Caucasian and other populations. Annals of the New York Academy of Sciences, 1281(1), 51–63. https://doi.org/10.1111/j.1749-6632.2012.06838.x

Narayan, K. M. V., & Kanaya, A. M. (2020). Why are South Asians prone to type 2 diabetes? A hypothesis based on underexplored pathways. Diabetologia, 63(6), 1103–1109. https://doi.org/10.1007/s00125-020-05132-5

Patel, K. C. R., & Bhopal, R. (2007). Diabetes epidemic in the South Asian Diaspora: Action before desperation. Journal of the Royal Society of Medicine, 100(3), 115–116. https://doi.org/10.1177/014107680710000303

Unnikrishnan, R., Gupta, P. K., & Mohan, V. (2018). Diabetes in South Asians: Phenotype, Clinical Presentation, and Natural History. Current Diabetes Reports, 18(6), 30. https://doi.org/10.1007/s11892-018-1002-8

[transmutationisms]

this hasn't happened to me in a long while, but when I was a kid getting weighed I remember a doctor pulling out a separate BMI chart for Asians with lower cutoffs. this was around a decade ago. no doctors have done this since. is that like, normal? or in any way meaningful?

'normal', unfortunately yes---I don't know that I've heard of doctors actually making up charts for this but it is a commonly held belief among physicians and epidemiologists that BMI cutoffs should be lower for Asians than for whites, because Asians supposedly have higher rates of weight-correlated adverse health outcomes (diabetes, CVD, &c) at the same BMIs.

meaningful is a different matter. there are two major and really damning issues with this belief:

firstly, the (handful of) studies documenting this disparity have all the same issues as any other medical literature on weight and health. we don't actually have good evidence to say that weight causes these health outcomes; it's difficult to disentangle environmental factors, or the fact that disease can often cause the weight gain itself, as in the case of diabetes or 'metabolic syndrome'. weight stigma, not interchangeable with weight itself, has a massive and documented negative effect on health outcomes. also, as far as I can tell, most if not all of the studies on this particular question seem to have been done using Asian-American subjects specifically, so that opens a whole host of further statistical ambiguities: you're talking about immigrant populations in the US. physicians love to interpret shit like this as evidence of biological racial differences instead of probing questions like: does this suggest that Asian immigrants to the US are subjected to forms of marginalisation that cause particular health effects? and the usual critiques of weight science include the problem that long-term deliberate weight loss is not achievable for th vast majority of people save through the development of behaviours that would otherwise be identified as eating-disordered, so BMI chart cutoffs are of pretty limited value for individual health guidance even if we were confident in their causal relationships.

secondly, and arguably even more fundamentally, any data that purport to differentiate people on the basis of race are data that are using an invented social category, not a 'natural' or biological one. there are absolutely health outcomes and conditions that affect different populations at different rates or with varying effects. but 'Asian' is not a coherent category genetically, epigenetically, historically, physiologically, or anything else. it's no more a 'real' biological grouping of people than 'white' or any other racial category. these are social designations, they're not biological facts. medicine that purports to display sensitivity to marginalised groups by reifying the biological ideology that defines them is reactionary at its core, and is not even solving the problems people think it is. when we lean on the idea of racial health disparities, we're basically relying on a crude average of a whole bunch of different people and groups who have been socially slotted into one 'race' category. this doesn't help people; on the contrary, it often obscures the actual rates of particular health issues in different populations: for example, the gene responsible for sickle cell anemia is common in families from many parts of the world, and sickle cell anemia is not a 'race-based disease' but an inherited genetic disorder. the allure of 'innate racial differences' as an etiological explanation is still pervasive and pernicious in medicine as elsewhere. Rana Hogarth talks about this in the epilogue to Medicalising Blackness, and I've also heard Iris Clever discuss it in conferences, although to my knowledge her published work focusses more on the epistemological architecture of genetic and anthropological databases. anyway my point is that, even if we solved all the issues raised in part 1 above and were confident that we had indeed pinpointed BMI cutoffs causally linked to adverse health effects, it still would be harmful and not helpful to set these cutoffs on the basis of 'race', which is a social system of categorisation and marginalisation and has no biological basis or 'natural' justification.

[eatmangoesnekkid]

You must water yourself and feed the tissues in your body with the light from your thoughts, perceptions, nutrition, to the things you watch, listen to, and read. This doesn't mean that you try to escape the tragedies of the external world. It does mean that you understand that your body responds to your own love and care more than anything else. Daily care and aftercare are essential during times of war and peace. As we sit with the paradox and nuance of being human and our predatory animal nature to take, pillage, and harm, we must show up for it all, including caring for our bodies. Your body responds to your daydreams, thoughts, and touch. When you touch your body, let your heart be as light as a feather...as much as possible. The light in your hands sculpt, shape, and heal your body. I told my friend the other day that my breasts sit up the way that they at 47 years old because of how much love I have given them over the last 15 years, how much I take time and care with my body, how often I lay back and just listen. So many of us with breasts carry burdens in our bodies year after year. God needs us to transmute all the shame, tension, anger, repression, embarrassment, and fear so that we can access more of our divine nature to help evolve this world by channeling raw and uncommon solutions.

Because if the voting and marching were working, we would be not be where we are in the world today. I still bow to my sisters and brothers who are on the front lines. But what I also know to be true is that we must take time to detox in order to recalibrate the hate, repression, shame, and war living in our epigenetic line that continue to create war in our bodies--the diabetes, cancer, chronic jealousy, womb aches, breasts ache, lack of sensation, and lack of full-body orgasms, and also the molestation and scarcity in the family line. These entities. We can't continue to "take in" and not let out.

Bringing More Love to Your body Changes the World Around You and Opens Up More Pathways to Love and Loving

When you live "spirituality" as a lifestyle, more of your DNA unlocks open. When there is high emotion in the collective, I transfer that energy into self-care--bathing, skin care, making good food, listening to good music, resting and caring for who and what is around me. I made a bone broth chicken soup and brought some to my massage therapist. I know what's happening in the world but I'm not constantly attuned to it in the 3D, meme after meme, news story after news story. I'm living life that around me and praying for those who are fighting for their actual lives. I do not take for granted what it means to have more freedom.

Shifting my focus in various ways over the years has kept my body more nourished and youthful than what it would have been otherwise. I priortise sweating often, lik in a dry Finnish sauna, wet sauna, or sweating while working out in high intensity classes. I have no goal to stay younger-looking. I love being grown AF. It is merely what naturally happens when we take care ourselves (our cells) and release, release, release. When we release, our tissues let go and bodies respond favorably. Our care creates the conditions that allow our bodies to flourish in ways in which we beautifully and radiantly age, but we don't age as quickly. -India Ame'ye, Author

[sunset-peril]

I actually tend to hc that all the Links are descended from another at some point.

However, what do you think about epigenetics being a viable reason for such?

You mean epigenetics being the reason they all are similar? Or that epigenetics is the reason they're all descendants of each other? I'm not sure I understand the question.

However, considering that epigenetics regards the condensed-ness (that's not a word but oh well) of the histones and the DNA wrapped around them and that most epigenetic changes are extremely reversible due to being caused by environmental stimuli (the only epigenetic changes that are permanent being CpG methylations in gene promoters, because those control cell differentiation.), I don't think epigenetics would leave a permanent mark on all Links as a whole. If Twilight Princess was Ocarina of Time's grandson or great-grandson, then that would be the only time I could see epigenetics playing a role in more than one Link. However, I think the rest of them are too far apart in the bloodline to have any real epigenetic effect on each other. Generally, epigenetic changes have been reversed after two or three generations, unless whatever stimuli that caused the original modification was persistent. (We used diabetic rats and poor/proper dieting for this study, and research on psychological epigenetics is still very new)

Although now that you mention this, I am curious to see how epigenetics would play a role in BotW/TotK's children.

I hope that answers the question!

For me I definitely hc that Skyward, Ocarina, Twilight Princess and BotW/TotK being all relatives (BotW being descended from TP literally being a foundational piece in my lore). I just don't know enough about the rest of them to decide for the rest of them.

[magnoliamyrrh]

Aren't there some diseases or genetic disorders which are more common among races though?

yeee so. this is actually a common misconceptions which has caused a lot of issues in medical fields - like in america for example, "black" people are sometimes misdiagnosed or not diagnosed with some conditions because of this belief

there are conditions which are more common in ethnicities, not races. because "race" is an incredibly broad concept which encapsulates several ethnicities, some which have great genetic variability among each other

since i brought it up per example its thought that sickle cell anemia is a "black" or "african" condition (as in some places where malaria is present, a kind of sickle cell helps give immunity to malaria). however, the higher presence of sickle cell is present only in certain regions of africa and in certain peoples, not across the entire continent - the continent of africa having the highest genetic diversity between groups of any other

on the same topic, in america black people are often classified as one "race" believed to have similar health conditions. however, the vast majority of african americans here are mixed with a wide variety of other ethnicities, as well as often more than one african ethnicity. thus, genetically speaking, there is variation and it is much more complicated. while the shared history of slavery and systematic opression has similar epigenetic impacts, it is again, more complicated than just one "race." this also leads to many cases of medical malpractice, in which people of several races in america are often Assumed to have xyz condition or to not have xyz condition because it is not common in their "race," when they may or may not have it anyhow, or when it is their ethnicity which matters and not this

other examples would be uh idk europe. it is said oh, europeans are more prone to xyz. this is true in some cases, but it goes by ethnicities. there are several ethnicities in europe. blood type it has been found affects rates of several diseases, including cancers, diabetes, autoimmune things, and many other stuff.... however, based on ethnicity, not "race", people are more likely to have a certain blood type group which would affect them. this goes for other things

ooorr idk another example. it is often said oh (insert race here) is lactose intolerant. except even though yes, there is a global distribution of who is and isnt lactose intolerant, there are Several, not one, genetic mutations which make one able to drink lactose, which have evolved in several regions of the globe separately - from places in africa to the middle east to europe to asia. thus, ethnicity and the history of that ethnicity is what determines this, not "race"

this isnt a very in depth reply but as a quick answer i hope it makes sense. "race" is Wayy too broad of a concept to base any sort of medicine on

[jacensolodjo]

"Children from women who became pregnant after the famine was over also showed what have been interpreted as effects caused by a Lamarckian change to their mothers. The offspring of the mothers and fathers who lived through the famine showed a higher propensity for diabetes, abnormal weights from eating disorders, and various cardiovascular ailments that shortened the life spans of these first generation children. Yet it was the unexpected appearance of higher proportions of similar ailments in these children's children that surprised scientists and in many ways remains one of the most singular proofs of the dark side that epigenetic change can produce."

[bluescreening]

op is in fact extremely fucking right in regards to type 2 diabetes. it's mostly or sometimes entirely genetic factors. People with lifestyles with a lot of exercise and diets that are low in sugar very much get type 2 diabetes, as much as people who do not exercise and eat a lot of sugar don't. It's indiscriminate and the whole stigma and idea around type 2 is fatphobic diet pushing bullshit basically

hi op! i am a biology student studying to research autoimmune diseases like my relatives who are also biologists researching diabetes.

you're right, type 2 diabetes is caused by a variety of genetic and epigenetic factors, almost all of which only actually cause type 2 diabetes when someone eats too much sugar for their entire lifetime. therefore someone is normally only at risk for type 2 diabetes when they eat way too much sugar for their entire lifetime. you're also right in that some people who don't eat way too much sugar get type 2 diabetes, but it's very misleading to suggest that they make up the majority.

type 2 diabetes is very much not indiscriminate. it stems from insulin resistance which normally only occurs when someone eats too much sugar over a long period of time. type 1 diabetes, however, is when the body produces no insulin whatsoever.

type 2 does not have a stronger genetic link than type 1 because type 2 is largely due to epigenetic changes and single nucleotide mutations which are highly variable generation on generation and can happen to anyone. they are even highly environmental (or at least epigenetic changes are) which means they won't necessarily run in a family line. type 1, however, is a straight up autoimmune disease. it has an extremely strong genetic link (e.g. every descendant of my diabetic great aunt has diabetes while i do not).

as for your last point, it did give me some pause - perhaps I was exaggerating a little to say it could be cured. but according to diabetes UK, "some people with type 2 diabetes who improve how their body makes and uses insulin through weight loss may be able to put their diabetes into remission." you might think that the weight loss part is irrelevant compared to sugar intake but actually fat buildup around the liver and pancreas leads to insulin resistance so. make of that what you will.

i know that it must be difficult living with type 2 diabetes and fatphobia is of course a rampant issue in modern society. but type 2 diabetes is one of few illnesses associated with obesity which are actually directly linked to your diet. note that I never mentioned obesity as a risk factor so far, but instead talked about eating too much sugar. eating too much sugar leads to obesity and also type 2 diabetes. people shouldn't judge people for eating what they want, regardless of their health, but it's important not to spread misinformation regarding preventable disease.

in short, it's more than ok to be fat, just try to eat a healthy diet and you probably won't get diabetes.

[ilentari]

First's (not-Yoichi) older brother was the only person who was in essence a genetic copy of him. Or well, the one most identical to him, since siblings share 100% of compability in genes, while parents only share 50% with their children, and grandparents 25%.

There is even a saying that goes 'if you have siblings, they are, technically, alternative versions of youself'.

So, it is very likely that there were some recessive vampire genes on him or something like that, that has been passed down to his descendents; it could, very well, explain why Hisashi was so strong even as a human and has so many magic affinities.

Or...

There is this thing called epigenetics, where some genes don't express themselves unless you are under the circumstances that forces you to manifist them.

By example, someone could have the epigenetics genes for diabetes, but never manifest it in their lives if they take good care of their diet and do exercise daily; while in the contrary, if they do the opposite, the diabetes would manifest themselves.

If First, before being born, was under the circunstances that could have turned him into a vampire, that's most likely the reason that he was born a vampire and his brother wasn't.

It doesn't mean that the brother could not have manifisted it later on in his life by some reason, but that was not very likely in that point.

If it was indeed, a recessive genetic thing, then it remains in what I previously said about Hisashi's strenght most likely coming from his great (x100) grand-uncle.

It remains to see what happens when someone that has not dominant vampire blood, that comes from the royalty family themselves, gets turned.

First and his older brother were not genetic copies. Siblings do not share 100% of their DNA, unless they are identical twins. If siblings shared 100% compatibility, then all siblings would look identical to each other. Due to genetic recombination and a bunch of chromosome shuffling and all that science-y stuff, siblings do get 50% of their DNA from each parent, but it’s not the same 50% each time. Each sibling has their own unique chromosome combination, which is why siblings don’t all look the same all the time.

Full siblings on average share about 50% DNA, but it can be less or more depending on chromosome combinations and all that. You can read more about that kind of thing here because I’m certainly not a biologist: https://atlasbiomed.com/blog/do-siblings-have-the-same-dna-the-facts-on-family-genetics/

I don’t think First’s vampirism was really due to a recessive gene so much as it was a random genetic mutation. So First’s brother did not have any sort of gene that would have resulted in him manifesting as a vampire at some point. First’s genes were just a fluke mutation. He was born a vampire.

Some of Hisashi’s strength and magical abilities do have a connection to him being a distant relation to the royal line though! First’s older brother was also very powerful, even without the vampirism.

[a-typical]

Scientists Have Reached a Key Milestone in Learning How to Reverse Aging

Loss of epigenetic information as a cause of mammalian aging

Scientists Have Reached a Key Milestone in Learning How to Reverse Aging

Highlights from the Study

Cellular responses to double-stranded DNA breaks erode the epigenetic landscape

This loss of epigenetic information accelerates the hallmarks of aging

These changes are reversible by epigenetic reprogramming

By manipulating the epigenome, aging can be driven forward and backward

“Underlying aging is information that is lost in cells, not just the accumulation of damage,” says Dr. David Sinclair, a professor of genetics and co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School. His latest results seem to support that theory.

All living things experience entropy manifested as a loss of genetic and epigenetic information. Genetic information is the hardware and the epigenome is the software. We think aging is due to corrupted software, that can be rebooted to restore youth.

It’s similar to the way software programs operate off hardware, but sometimes become corrupt and need a reboot. But by showing that we can reverse the aging process, that shows that the system is intact, that there is a backup copy and the software needs to be rebooted.”

In the mice, he and his team developed a way to reboot cells to restart the backup copy of epigenetic instructions, essentially erasing the corrupted signals that put the cells on the path toward aging. They mimicked the effects of aging on the epigenome by introducing breaks in the DNA of young mice. - Once “aged” in this way, within a matter of weeks Sinclair saw that the mice began to show signs of older age—including grey fur, lower body weight despite unaltered diet, reduced activity, and increased frailty.

The rebooting came in the form of a gene therapy involving three genes that instruct cells to reprogram themselves— These genes came from the suite of so-called Yamanaka stem cells factors—a set of four genes that Nobel scientist Shinya Yamanaka in 2006 discovered can turn back the clock on adult cells to their embryonic, stem cell state so they can start their development, or differentiation process, all over again. Sinclair didn’t want to completely erase the cells’ epigenetic history, just reboot it enough to reset the epigenetic instructions. Using three of the four factors turned back the clock about 57%, enough to make the mice youthful again.

Using a system called “ICE” (Inducible Changes to the Epigenome), we show the act of repairing DNA breaks accelerates aging at the physiological, cognitive, & molecular levels, including erosion of the epigenetic landscape, loss of cell identity, senescence & increased epi-age ... "We show these changes can be reversed by OSK-mediated rejuvenation. With an ability to drive aging in both the forward and reverse directions, we conclude that loss of epigenetic information is a cause of aging in mammals."

“We haven’t found a cell type yet that we can’t age forward and backward.”

In 2020, Sinclair reported that in mice, the process restored vision in older animals; the current results show that the system can apply to not just one tissue or organ, but the entire animal. He anticipates eye diseases will be the first condition used to test this aging reversal in people, since the gene therapy can be injected directly into the eye area.

"If correct, it means that cancer, diabetes and Alzheimer's might have the same underlying cause that can be reversed to treat or cure age-related conditions with a single treatment. Experiments in the lab are testing this."

Even before that happens, the process could be an important new tool for researchers studying these diseases.

"The age-reversal technology -- virally-delivered genes (Oct4, Sox2, Klf4, aka, Yamanaka factors), which turn on an embryonic program -- is being tested at @lifebiosciences in non-human primates. Results out in a few months from Bruce Ksander's lab & http://lifebiosciences.com"

[ofthefog]

Just to make sure we get the claims right here, I am saying that sugar consumption increases risk for type 2 diabetes. The majority of studies on the subject find this, across 174 countries. Decreasing sugar consumption also reduces this risk.

Furthermore, if genetics was the only cause, then we would not see a large increase in the prevalence of type 2 diabetes unless there were some environmental factor.

Now, whether the cause of this is obesity or sugar or fat intake or just overall energy is where the debate is. I've actually talked about the lechtin mechanism regarding obesity mentioned in your linked article in another post I made about the epigenetic of famines, particularly in china and the netherlands.

This meta analysis links sugar intake and type 2 diabetes.

This is true for diverse populations, such as this study on the Palestinian population.

Chinese and Singaporean data.

Global look, which outlines the increase of Diabetes and it's correlation with sugar consumption.

Now on practical and individual terms, we don't have to be specific about diabetes. If you drink a lot of soda pop, maybe try switching that out for water ever now and then and see how that feels.

It might be that you just have a rare reaction to a normally inert ingredient but if you feel better from cutting it out, then it works And if it doesn't change much then you know.

There's a lot of posts online like "when you hit 30 and you can't eat Mexican food without blowing up your toilet" or "when you hit 30 all those random scratches you get never heal" or "Your back starts hurting right when the birthday hits"

I hate to break it to you but if that applies to you that is not a direct result of arriving to the still youthful age of 30, that is a medical condition that you have assumed is normal.

The good news is that some of these can be fixed with relatively small lifestyle changes like regular stretching and moderate exercise. Now some of this is requires going to a doctor and diagnosed and treated. I know that can be difficult if you're not paid enough and don't have vacation or sick days.

Hell, the job itself can break your body down, whether it be from sitting inside for hours and hours, or doing manual labor in the sun all day.

In any case, you should examine how your lifestyle affects the way you feel every day over time. Was being a kid truly a world apart, or was it just that you regular played outside and got some sun, and you did novel stuff all the time with friends, and you didn't smoke and drink?

I was certainly surprised by how much lifestyle affected my chronic illness. I had thought I was doomed to feel bad randomly forever. But years on, I actually feel better than I did on net even before symptoms began to manifest.

It turns out that having more autonomy can vastly improve your life! Wild stuff. But it's something you have to be conscious of and practice to make the most use out of.

[communicationblogs]

Epigenetics Market — Forecast(2024–2030)

Epigenetics Market Overview:

Owing to the world-class healthcare infrastructure in North America coupled with the significant contribution to drug development is driving the epigenetics market in the region. More than 1,919 medicines for cancer treatment are in the development stage,[2] according to the International Federation of Pharmaceutical Manufacturers Association (IFPMA), and North America bears a substantial share of this development owing to the greater investments in the region. The rates of people suffering from cancer and cardiovascular diseases in the region have also driven the market in the region. In 2018, North America had the greatest epigenetics market share of 39%.

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Epigenetics Market Outlook:

Epigenetics is defined as the study of heritable changes in phenotype without alteration in the DNA sequence or nucleotide sequence which can be due to DNA methylation or DNA adenine methylation, generally enabled by Streptococcus pneumonia in bacteria. This is chiefly used in diabetics wound healing or treatment of other conditions that occur due to genomic imprinting. Epigenetics market generates revenues in hospitals and research institutes.

However, the most prevalent application segment in the epigenetics market is in the services regarding epigenetics. This is much attributed to the fact that not all hospitals have their own research unit. Moreover, many hospitals have tie-ups with research institutes that provide epigenetics services, which happens to be the reason responsible for the growth opportunities in the services segment of the epigenetics market which is projected to rise with a substantial CAGR of 11.20% through to 2030.

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Epigenetics Market Growth Drivers:

The Growing Number of People Suffering From Cardiovascular Conditions 

According to the World Health Organization, cardiovascular diseases (CVDs) is the leading cause responsible for the deaths of people, and an estimated number of 17.9 million people died from CVDs in 2016 already.[3] Epigenetics is now considered as the foundation for the diagnosis and treatment of CDVs as it has a major cardiovascular medicine specialty in conditions such as coronary artery disease, heart failure, cardiac hypertrophy, and diabetes. The millennial lifestyle that involves the unhealthy diet, lack of exercise, cholesterol issues, and obesity are some of the factors that are makings CDVs prevalent, which is enhancing the revenues generated in the epigenetics market.

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The Pervading Concern Regarding Birth Defects Supporting the Market 

Birth defects have become common, expensive, and more importantly critical. In the United States alone, one in 33 babies are born with birth defects, and these defects are the leading cause of 20% of infant deaths,[4] according to the findings by the Centers for Disease Control and Prevention (CDC). Evidently, epigenetics finds application in diagnosis and treatment of these birth defects as it helps to establish the molecular basis for the gene-environment interactions. The implementation of epigenetics in the treatment of birth defects is still under constant R&D. However, the future foresees an augmented application of epigenetics in the treatment of birth defects as a crucial driver for the epigenetics market demand growth.

The General Application of Epigenetics in Drug Development 

The healthcare sector is making strides with over 7,000 number of medicines under the development stage. Apparently, the epigenetics market has paved its path into the development of the medicines. Nowadays, uncommon diseases have been proliferating through the globe, which is making the development of new medicines imperative. Development of new medicines for the cure of these uncommon diseases is leading to new horizons in the epigenetics market.

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[diabetesreversalprograminindia]

Weight Issues in Kids: A Diabetes Warning

This article is originally published on Freedom from Diabetes website, available here.

Childhood obesity in India has reached epidemic proportions. It is no coincidence that India is also leading in the race to become the next diabetes capital of the world. The connection between obesity and metabolic disorders, like diabetes, Blood Pressure, and heart disease, has already been established. So what will the future be like with a massive young but overweight population coming around the bend.

The medical implications are enormous and so are the financial considerations. It is imperative that this problem be tackled at the micro-level, i.e. in every family. But before we look at treatments, let us understand what has caused this situation to begin with.

What are the main causes of childhood obesity?

In this huge population, Childhood obesity in India has reached epidemic proportions. Childhood obesity has become a serious problem in recent years. There are many causes of childhood obesity. There is no single cause of childhood obesity. There are several inter-related factors, including biological, developmental, behavioral, genetic, and environmental ones.

Recent studies show that factors like epigenetics (how behavior and environment affect gene function) and the gut microbiome are contributing to the increasing number of obese people.

The environment play a big role, it has a big impact. As people get wealthier, their diets shift from simple, healthy foods to modern ones high in fat, sugar, salt, and preservatives. Urban living also leads to a more inactive lifestyle with little exercise.

Lets understand their reasons one by one.

Nurture or Nature?

If your parent or grandparent is overweight, it's more likely that you might be overweight too. Research shows that children of overweight or obese mothers are more likely to be overweight by age four. This is regardless of their BMI at two. On the other hand, studies show that children born in families where neither parent is overweight are less likely to be overweight. This is of course by no means definitive, as there are many other factors that have a bearing too. For instance: stress.

Stress

Sometime Children living in a stressful environment are more likely to be overweight than those living with less familial stress.

Parental Guidance

Your parents should be educated. They should know, how to take care about your health. They should have understanding of the role nutrition and physical activity play are other factors, as are school and community influences, such as access to fast food restaurants, excessive screen time, whereas proximity to parks is known to reduce the risk of being overweight.

Health Risks of Childhood Obesity

Childhood obesity brings many potential health implications. Obesity during childhood will increase the risk of hypertension, high cholesterol, high triglycerides, and even osteoarthritis.

It also significantly raises the danger of contracting diabetes type 2, coronary problems, stroke, respiratory problems, mental health issues, and some cancers. Little wonder then that India is projected to be the world’s diabetes capital.

Prevention & Treatment

The WHO describes childhood obesity as one of the 21st Century’s most serious public health challenges.

How to prevent childhood obesity:

Consuming more fruits and vegetables Greens are high in nutrients and fibre, and they are also low in calories and carbohydrates. Vegetables like cauliflower and cabbage are potent weight loss foods, as are fruits like apples and pears. So try to eat more vegetable and fruits.

Minimizing screen time This generation is using mobiles more. And even parent allowed them. But this not good for them. Watching TV just compounds the problem. Keep busy your kids with other activities, like logical games, or other which is useful for them. Avoid this screen time.

Lowering sugar intake

Sugar is the chief component of the flavoured beverages children love so well. But it’s frighteningly high in sugar, which as we all know is also highly addictive. Water is a far healthier substitute and should be encouraged. A good preventive measure is to avoid stocking your fridge with sugary drinks.

Increasing physical activity Academic pressures/competitions and limited time has resulted in less physical activity. Your kids should spend time on the playground is a must to combat the effects of unhealthy diets and sedentary living. Parents should encourage their children to get at least an hour every day –playtime in the open air for younger children and vigorous physical activity for older ones.

5.Parental Role Parent are role model of their children's. So parents should be more careful about their behavior. Because Children see what parents do and behave accordingly; this includes eating habits. Parents who eat more fruits, vegetables, legumes, and whole-grain, and nuts are more likely to have children who have healthy eating habits too. So parent have to follow these rules, so their kids will automatically do!

Milk and milk products should be avoided as far as possible. There are better non-dairy substitutes with a higher and cleaner nutrition palette.

Cut our or at least reduce consumption of fast foods. These are invariably high in sugar, salt, and fats.

Cut out snacking entirely. It leads to grazing, which is just a manner of continuous eating.

Avoid force to your child to eat, as it can lead to poor self-control and obesity. Teach them to eat at regular times, and don't use food as a way to pass time or as a reward. Be preventive and be healthy! To read more about this, please visit our Article. Be preventive and be healthy! Also please connect with me on my website, Facebook page, and YouTube if you want to stay in touch or give me any feedback!

[sciencepills]

Epigenetics and diseases.

How epigenetics can influence the onset of diabetes. The impact of lifestyle Lifestyle plays a crucial role in influencing the epigenetic changes that can contribute to the onset of diabetes. Factors such as diet, exercise, stress levels, and exposure to environmental toxins can all have a significant impact on the epigenetic modifications that affect gene expression. But what is this…

[krismorgenstern]

Epigenetics also come into play with those whose ancestors were enslaved, the stresses of which don't disappear until about 10 generations of relatively little stress. In addition to mental effects, this can also make a person more likely to develop physical imbalances such as obesity and diabetes. And of course, the epigenetic triggers making a person more susceptible to such things don't switch off if that person and their family continue to experience violence generation after generation.

scientist voice: today i will be a dick to this cricket 

[crimsonpublishersobesityjourna]

Importance of Antidiabetic Medicinal Plants in the Prevention and Management of Insulin Resistance: Case of Gestational Diabetes in Cameroon

During pregnancy, insulin resistance increase over time. So in the last four months of the pregnancy, insulin resistance upsurges significantly and can become severe, specifically in women with gestational diabetes and type 2 diabetes. Various factors including placental hormones, obesity, and inactivity, an unhealthy nourishment, and inherited and epigenetic influences negatively impacts insulin resistance in pregnancy, but the causal mechanisms are multifaceted and still not completely elucidated. Therefore in this review, we seek to identify among antidiabetic plants usually used in Cameroon those which can regulate insulin resistance in pregnant women, with diabetes. To achieve this objective a literature search was performed in Google, Google Scholar and PubMed, using the key “plants improving insulin sensitivity or insulin resistance in gestational diabetes”. The phytochemicals with insulin resistance and insulin sensitivity of recorded antidiabetic plants and their action mechanisms were compared with those of antidiabetic plants regularly used In Cameroon. The phytochemicals and their active mechanisms were searched using the keys «what is a given compound) chemical group(s). A list of Cameroonian known antidiabetic plants improving insulin sensitivity and insulin resistance were established. Nineteen (19) antidiabetic medicinal plants usually castoff in Cameroon have been reported to have a beneficial effect on insulin sensitivity and insulin resistance with regard to the presence of molecules which improve insulin sensitivity and insulin resistance in their chemical composition. Finally, well-chemical study, well mechanisms elucidation and well-designed randomized controlled trials with lasting consumption are still required to assure the bioactivity and safety of these medicinal plants and compounds for gestational diabetic patients.

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