#Endocannabinoid Receptors

[stonedcoast]

Artificial Intelligence

It's been a week, again! Here's my first Ramble since starting the blog. It's a little off topic, but it should lead to some interesting writing in the future. I hope you enjoy!

I could see myself doing an insane deep dive into Artificial Intelligence: there’s no lack of writing on the topic, it’s constantly improving, and we’re gaining access to it casually more and more every day. But this is a cannabis blog, and this was meant to be a filler post this week, as I am (as is noted in the AI chat I’m linking below) in between anniversary bookends, with my own having been…

[stonerzelda]

this weed education certificate is kind of fun but all i can think abt is how much the voice sounds like the missile

[ailurinae]

I thought that couldn't be true, neuroreceptors are old as shit, and I know for sure some other invertebrates have cannabinoid receptors... but turns out that insects, perhaps uniquely, have lost those receptors

The endocannabinoid system also appears to be phylogenetically ancient--it occurs in mammals, birds, amphibians, fish, sea urchins, leeches, mussels, and even the most primitive animal with a nerve network, the Hydra.

Surprisingly, we found no specific binding of the synthetic CB ligands [(3)H]CP55,940 and [(3)H]SR141716A in a panel of insects: Apis mellifera, Drosophila melanogaster, Gerris marginatus, Spodoptera frugiperda, and Zophobas atratus

[medicomunicare]

Meet beta-caryophyllene, the last novelty in fighting selectively chronic pain

Chronic pain afflicts millions of people around the world and represents a healthcare expense that cannot be effectively mitigated. The use of NSAIDs and opioids is not always effective in all its forms; this is why research has turned to other molecular pathways different from those affected by these two categories of drugs. Neuropathic pain, for example, is a debilitating condition that results…

[budandtender]

The Endocannabinoid System: Exploring the CB1 and CB2 Receptors

Introduction

The endocannabinoid system (ECS) is a complex network of receptors and neurotransmitters that plays a crucial role in maintaining physiological stability, also known as homeostasis. Two primary subtypes of cannabinoid receptors within the ECS are CB1 and CB2. These receptors are distributed throughout the central nervous and immune systems, and their discovery has revolutionised our understanding of how the body functions.

Discovery of Endocannabinoids

Following the identification of cannabinoid receptors, scientists embarked on a quest to uncover the substances produced naturally within the body that bind to these receptors. In the early 1990s, this pursuit led to the discovery of the first endocannabinoids, anandamide and 2-AG. Since then, three additional endocannabinoids have been isolated. These endocannabinoids, being fats, are not water-soluble, which limits their ability to efficiently move through the body. As a result, they primarily function locally.

Local Activity and Synaptic Function

One important local activity of endocannabinoids occurs when they act as the primary messengers across synapses, the gaps between nerve cells. By signalling neurons to communicate with each other through the release of neurotransmitters, endocannabinoids play a vital role in modulating the flow of neurotransmitters. This modulation ensures the smooth functioning of our nervous system. Recent research has revealed that the role of endocannabinoids in synaptic function is more significant and complex than previously believed.

Homeostasis and Disease

Endocannabinoids are produced on demand, released back across the synapse, and rapidly metabolised within cells. They are closely associated with the concept of homeostasis, helping to restore specific imbalances caused by disease or injury. The role of endocannabinoids in pain signaling has led researchers to hypothesize that their levels may be responsible for the baseline of pain throughout the body. This hypothesis opens up possibilities for using cannabinoid-based medicines in the treatment of conditions such as fibromyalgia. Furthermore, the continuous release of endocannabinoids by the body may have a "tonic" effect on muscle tightness in multiple sclerosis, neuropathic pain, inflammation, and even baseline appetite.

CB1 Receptors: The Brain's Circuit Breaker

The CB1 receptor is widely expressed throughout the brain, forming a crucial component of the ECS. When endocannabinoids bind to CB1 receptors, they act as a "circuit breaker," modulating the release of neurotransmitters. The impact of the endocannabinoid system on brain function is vast and encompasses various regions. However, it is worth noting that the brain stem, responsible for vital functions like respiration and circulation, has relatively few CB1 receptors. This scarcity explains why cannabis overdoses are not fatal. Activation of the CB1 receptor is primarily responsible for the psychoactive effects associated with cannabis consumption.

CB2 Receptors: Guardians of Immune Function

In contrast to CB1 activation, which elicits psychological and physical effects, CB2 receptor activation does not produce these effects. CB2 receptors are primarily found in blood cells, tonsils, and the spleen. From these locations, CB2 receptors regulate the release of cytokines associated with inflammation and general immune function throughout the body. Understanding the role of CB2 receptors provides insights into how the ECS influences immune responses and offers potential avenues for therapeutic interventions targeting inflammation-related disorders.

Conclusion

The discovery of the CB1 and CB2 receptors within the endocannabinoid system has unveiled a fascinating network that regulates numerous physiological processes. From modulating neurotransmitter release in the brain to controlling immune responses throughout the body, the ECS plays a vital role in maintaining homeostasis. Further research into the endocannabinoid system and its receptors will undoubtedly shed more light on their intricate functions and pave the way for novel therapeutic approaches.

[genderqueerdykes]

I saw your post about estrogen and nicotine. Do you know if there's anything out there about other forms of smoking (weed is the one I'm specifically curious about). Thanks 😊

this is an interesting question as well!

this one seems to be a toss up, however the endocannabinoid system is closely linked to and affected by hormones, and vice versa. it would seem as for some people, using estrogen hrt can cause the body to become more receptive to the effects of cannabinoids, whereas others find that using cannabis may make them more or less susceptible to processing estrogen HRT.

however, there are a very small amount of studies being done on this, and some of them seem dubious at best or rather flimsy. many of the studies i read have inconclusive answers, whereas with nicotine, there are a lot more studies being done on the matter. it seems that for most people, using cannabis will not affect estrogen HRT anywhere near as much due to nicotine as a substance neutralizes estrogens and dilutes the amount of them that you have in your body.

here's some information on the matter, which shows the subjective and inconclusive results, ranging from person to person, study to study:

i hope that helps and makes sense! good luck to you in your journey, if you have any more questions feel free to ask!

[maive-the-sheep]

Question for monster fuckers/teratophiles.

What do you all thing of venom?

Giving a love bite and any venomous affect.

Maybe paralysis. Maybe pain. Maybe activating endocannabinoid receptors (yes, there is a venom that does that, gets you high). Maybe bleed out. Maybe euphoric dazed bliss where can't comprehend much of what's happening. Maybe insulin (venom research is great).

Any creative usage, helpful usage, or protective usage.

[dollsahoy]

so one of the YT exercise channels I'm trying promises you'll feel a runner's high once the workout is over

of course I have not felt anything

so I looked up if runner's high actually even exists

yes, but it's not, as is commonly believed, endorphins--it's endocannabinoids (and, yes, that's the kind of drug you think it is, but made by the body)

and

if the brain has a tendency toward depression or anxiety, then it may lack enough receptors to get the natural high feeling from exercise

so...whoo.

[brightlotusmoon]

The endocannabinoid system (ECS) is a biological system first discovered in the late 1980s and early ’90s. It is largely composed of endogenous cannabinoid molecules (endocannabinoids) together with the receptors they interact with and enzymes that regulate their levels in the body. This simply means that the body produces native molecules which are similar in certain ways to plant cannabinoids like THC and play an important role in our normal biology.

The different pieces of the ECS “work together” to modulate everything from sleep to mood, memory, appetite, reproduction, and pain sensation. Scientists still have plenty of questions about the human endocannabinoid system and how it functions, but there is an overarching principle that the ECS seems to embody within the bodily tissues it helps regulate.

Homeostasis: Staying in the Goldilocks zone

[oddman-the-oldman]

Cannabis Body lotion

Mainly used at hour of sleep for night time pain

Cannabinoids 4 gm Δ9-THC 2 gm THC-Acid aka THC-A - Optional not currently added, 2021 03 15 15 ml β-caryophyllene specific to CB-2 forces THC onto other receptors like CB-1 15 gm Magnolol & Honokiol 95% aka Magnolia Bark Extract converted by your body into other cannabinoids.

Bio enhancers interfere with the breakdown of THC in your body and make the dose last longer 1 gm Piperine 95% 5 to 10 drops Lavender essential

Optional oils

10 drops Wintergreen essential oil 10 drops Rosemary essential oil 5 drops Black Pepper essential oil 5 drops Hinoki essential oil 5 drops Frankincense essential oil 5 drops Spearmint essential oil 7 gm MSM

The above is mixed with enough moisturizing body lotion to produce 1.5 cups of medicine. “Avalon Organics – Aloe Unscented” is my preferred carrier. Sleep atonia slows transport of this medication away from the application sight through the lymphatic system. The medication stains clothing with oils that are difficult to remove.

Application to the rib cage for the treatment of asthma is also done when the Hemp Oil Emulsion isn't enough. Eg. Heavy smoke from forest fires or wood heat in the environment. URI's such as colds and Flu.

It can be made stronger by adding more Δ9-THC up to 8 gm. I begin using it to treat surgical pain 48 hours after any major procedure. Nerve blocking is possible and was used when I broke my foot by placing the medicine behind my knee and on my lower back. Dose may be increased to 4 times daily during surgical challenges or major injury.

[canna-plus-cbd-gummies]

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Endocannabinoid System

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Therapeutic Effects

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Mood Regulation

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Regulation of Sleep Cycles

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[dafitness4shawn]

Hey y’all! Went for a run today. It was meh but what should I expect from the first run back. I’ll blame it on not being at sea level anymore. That’s not what I wanted to talk about though!

After smoking weed almost daily for 10 years, tonight marks 28 days of not smoking or ingesting THC. The significance of the number came from this video (https://youtu.be/7u_cm5b1s7Y). According to the video that’s when your “affected endocannabinoid system and CB1 receptors return to baseline.” I take that info with a grain of salt because we are not all built the same but it’s still nice to say I made it to that number, it’s the longest I’ve ever gone. I actually took a home-drug test at Day 14 (brand was Equate) and passed, which I was very surprised about and didn’t want to believe. I feel one reason people never touch the stuff is because you hear things like “it’s detectable for months!” However my lab tech girlfriend who deals with test very similar says it’s accurate and that the time it stays detectable is going to differ from person to person.

Anyway, if you’ve followed for a while you know that I’ve struggled in the past with taking breaks so of course I wanted to share this milestone. Definitely couldn’t do it without support. @emilweeb suggested supplements (specifically the Ashwagandha) and I heard the Magnesium Glycinate helps with sleep so I gave that a try as well. They definitely helped so much in the beginning. Recently I fell off with taking them daily but I’m gonna get back into it, especially since I do feel positive effects from them. Her advice behind the supplements was to replace bad habits with good habits. Also have to give credit to my girlfriend. She doesn’t smoke anymore but did just as much as me in the past/when we first met. Sometimes you need someone to tell you, “Don’t do that,” but in a loving, non-judgemental way.

I guess the question now is, “Am I done with weed forever?” The answer is no. I know I don’t want to be a daily user anymore, and I prefer not to get back into smoking, since no matter what you smoke, smoking is bad for your respiratory system, and that’s a fact. Not gonna lie though, I’m not saying I’ll never smoke again, just not going to make that my main method. I wanna ease back into it at my own pace. I have tinctures and edibles waiting for me when I decide to take that step, but even while writing this out I’m not in a rush to get high again, which is honestly, so weird to think.

I feel like there’s so much more I could add but this post is LONG. I’m always down to answers questions though if this post sparks any for anyone. I hope y’all are having a great day :)

[weirdmageddon]

you aren't in canada by chance? because i do have some experience ordering online in canada. As far as strains go, it's probably going to be more of personal preferences, other than the classic indica v sativa divide. As far as dosing goes, what was the dosage on your 1:1 gummies, and how did you enjoy them?

no i’m not in canada i’m in florida

i dont have 1:1 gummies, i never tried 1:1 THC-CBD

my edible experience has exclusively been

1.) gummies from nicks nugs (10mg Δ9 THC & 75mg CBD per gummy) though i cut it into quarters and dose based on vibes, never really a full gummy at a time. that ratio is 1:7.5, not 1:1. im not sure if it’s indica, sativa, or hybrid but i assume it’s primarily indica? they were from my friend and she uses them to sleep so i assume it’s primarily indica. but dosing wise i usually go for half to three quarters of a gummy with these parameters. half a gummy is 5mg THC & 37.5mg CBD. three quarters is 7.5mg THC & 56.25mg CBD.

2.) my neighbor also let me try a indica-sativa hybrid 5mg Δ9 THC cookie with no CBD and i liked the feel i got from it a lot. it felt new, like when i got high for the first time and my endocannabinoid receptors were THC virgins. it was more uplifting, i suppose with the greater bit of sativa mix in there. CBD seems to dampen or mediate the effects of THC so it also felt stronger than half a gummy (5mg) of nick’s nugs but it was good.

but the thing is i dont wanna take weed to go to sleep, but the friend who gave me them is very energetic and they help sedate her, and those nick’s nugs make me sleepy. i suppose finding the right strain for me is about figuring out what i like or want out of the high?

i like:

the sensory component of THC

having 60 fps interpolation for my sensory neurons and proprioception. the way music sounds, the way things look like they’re in 4K on my phone when im under the blanket

associative mental activity with physical relaxation

the infectious “2am at a sleepover” type of giggles

mild tactile hallucinations / hug feeling at higher doses

enhanced pareidolia

probably more i cant think of

i could do without:

being couchlocked

having munchies since im trying to lose weight (but i often fall asleep before i can even eat anything with nick’s nugs lol)

the next day “hangover” (sleepiness) where i’m not as alert

idk what concoction of terpenes would be for me

[cannatrendingnews]

Exploring the Wellness Benefits of Cannabis-Infused Drinks: A Sip Towards Better Health

In recent years, cannabis-infused drinks have emerged as a popular choice for wellness enthusiasts seeking alternative ways to enhance their health routines. These beverages, ranging from CBD-infused teas to THC-infused sodas, offer a convenient and enjoyable way to incorporate cannabinoids into daily wellness practices. Let's delve into the key benefits of incorporating cannabis-infused drinks into your wellness routine and discover how they can contribute to your overall well-being.

Stress Relief and Relaxation:

One of the primary benefits of cannabis-infused drinks is their potential to promote stress relief and relaxation. Cannabinoids like CBD have been widely studied for their anxiolytic properties, which may help alleviate symptoms of stress, anxiety, and tension. Sipping on a CBD-infused tea or beverage can offer a calming effect, allowing you to unwind after a long day and promote a sense of relaxation.

Pain Management:

Cannabis-infused drinks containing CBD or THC have shown promise in managing various types of pain, including chronic pain, inflammation, and discomfort. CBD interacts with the body's endocannabinoid system, which plays a crucial role in regulating pain perception and inflammation. THC, on the other hand, possesses analgesic properties that can help alleviate pain and improve overall comfort. Incorporating these drinks into your wellness routine may provide natural relief from pain without the need for pharmaceutical medications.

Sleep Support:

Many individuals struggle with sleep issues such as insomnia or poor sleep quality, impacting their overall health and well-being. Cannabis-infused drinks can offer support for better sleep by promoting relaxation and reducing anxiety, making it easier to fall asleep and stay asleep throughout the night. CBD-infused beverages are particularly popular for their calming effects, helping to quiet the mind and prepare the body for a restful night's sleep.

Mood Enhancement:

Maintaining positive mental health is essential for overall wellness, and cannabis-infused drinks can play a role in supporting mood balance and emotional well-being. CBD has been shown to interact with serotonin receptors in the brain, which are involved in regulating mood and emotions. By modulating serotonin levels, CBD may help alleviate symptoms of depression, anxiety, and mood disorders, promoting a more positive outlook on life.

Potential Neuroprotective Effects:

Emerging research suggests that cannabinoids like CBD may possess neuroprotective properties, offering potential benefits for brain health and cognitive function. CBD has shown promise in protecting against neurodegenerative diseases such as Alzheimer's and Parkinson's, as well as reducing the risk of age-related cognitive decline. Incorporating CBD-infused drinks into your wellness routine may help support brain health and cognitive vitality as you age.

When it comes to sourcing high-quality cannabis-infused drinks for your wellness routine, SipHowdy stands out as a trusted provider of premium CBD and THC beverages. With a commitment to quality, purity, and transparency, SipHowdy offers a diverse range of cannabis-infused drinks crafted with the finest ingredients and the highest standards of production. Whether you're seeking stress relief, pain management, or sleep support, SipHowdy has a beverage to suit your needs and enhance your wellness journey.In conclusion, cannabis-infused drinks offer a host of potential benefits for overall wellness, including stress relief, pain management, sleep support, mood enhancement, and neuroprotection. By incorporating these beverages into your daily routine, you can enjoy a natural and enjoyable way to promote health, balance, and vitality. With SipHowdy as your trusted partner in wellness, you can sip your way to better health and embrace the transformative power of cannabis-infused beverages.

[microdosingwithjoe]

CBG, CBD, CBC, CBN, and THCV

The Healing Cannabinoids

If you read my piece on the entourage effect, you know that I believe that THC is the ringmaster, but all the components of cannabis determine the “personality” of any given strain. Studies have proven the Entourage Effect with cannabinoids and terpenes. But these five cannabinoids are the major components that combine with THC to most affect your high as far as we know, as well your health and wellbeing.

Some cannabinoids, especially CBN and CBG, can bind directly to both the endocannabinoid system’s (ECS) CB1 and CB2 receptors, meaning they affect everything the ECS controls. These elements are all-important to the way any given cannabis strain or concoction affects you.

There are over 100 cannabinoids. We have no idea what most of them do, but the ones I selected are considered the most important.

CBG (cannabigerol) is the “Mother Cannabinoid” —THC, CBD, CBC, and CBN (and all other cannabinoids) began as CBG.

CBG’s anti-stress, anti-anxiety, and antidepressant effects are fantastic, but that’s just the tip of the iceberg. There are numerous studies about CBG that indicate that it is as good as or better than CBD for pain, anxiety, inflammation, sleep disorders, etc. —all CBD’s effects but even better. It also provides better relief for sufferers of intestinal disorders, like IBS, GERD, and Crohn’s disease. We will have to wait and see everything CBG does, because the THC and CBD study focus has been taking the lion’s share of interest before now, but CBG is the rising superstar.

CBD (cannabidiol) is a cure-all kinda medicine that continues to show positive effects in more and more conditions all the time. I have a personal affinity for CBD + THC therapy, as it substantially healed two discs in my neck, and turned my degenerative disc disorder around. I still can have bouts of pain, but compared with living with hearing and feeling bone-on-bone grinding all day, every day? I’m in heaven. Another attribute of CBD, is that it’s a THC antagonist. That means it can inhibit and regulate the uptake of THC, and that has two great purposes. If you’re a beginner stoner. I always recommend everyone get a CBD vape whether you’re a beginner or an expert stoner. If you get too high, feel THC-induced anxiety, or panic, just a few puffs of CBD, and you’ll be relieved. But because CBD has all these great benefits of reducing tension, anxiety, and depression, one puff is just a great additive to any high. Antagonistic CBD also stretches THC’s effective period from 4 hours, to 6-8 hours during sleep.

CBC (cannabichromene) may be up to 10 times more potent than CBD for treating stress and anxiety and also has significant anti-inflammatory, pain-reducing, antiviral, anti-tumor, and bone-growth-stimulating properties. But the potential CBC has that excites me most, is that could be immensely useful in promoting the growth of new brain cells.

As an old fart with diminishing mental acuity, that’s obviously interesting to me.

CBN (cannabinol) is the first known cannabinoid, but one of the least-studied of these five, and is the only one that isn't derived directly from CBG, but it's what THC turns into when oxidized. Unlike CBG, CBD, and CBC, it’s mildly intoxicating. Like all these cannabinoids, it relieves pain and inflammation.

The best-known effect of CBN, is that it makes you sleepy. Anyone who’s ever smoked an old joint they found in a drawer might remember that it didn’t get them very high, but it made them ready for nappy time; that’s because much of the THC has degraded into CBN.

What excites me most about CBN, is that behaves like THC in many ways, and it has been found to bind with CB2 receptors. This ability may lead to new treatments for neuropathy (no treatment currently exists, and I suffer from neuropathic pain caused by sciatica), as CB2 receptors appear in inflamed areas in the body.

CBN therapies will be able to treat virtually any inflamed site, so it has the potential to address other areas that are difficult to treat, such as gastrointestinal system disorders like GERD, Chrons Disease, and diverticulitis.

CBN could be a true wonder drug.

THCV (tetrahydrocannabivarin) is another under-studied cannabinoid that’s attracting attention, for good reason.

THCV is a very effective appetite suppressant. It’s also the opposite of CBN, making people quite energetic. Being a bit tubby, I’m really excited by it. I’ve had a rare strain that contained THCV, and can attest to these properties.

But more excitement is to come from THCV, as it has shown to treat a lot of other diverse conditions, including Parkinson’s, psychosis, bacterial inflammation, acne, fatty liver disease, pain, and epilepsy.

I can’t wait to see what other benefits THCV has! Durban Poison is a common strain that contains high levels of THCV, but I’ve never had as good an effect from DP as I did the first (forgotten-named) high-THCV strain I tried.

Entourage Effect- all these cannabinoids work together in ways that increase their effectiveness when combined with THC, and can’t be recommended enough for ailments and moods your ECS controls. There aren’t any drawbacks, except you probably won’t want to ingest CBN until bedtime.

Any and all of these cannabinoids can be ingested individually a half hour before imbibing your favorite weed. THC don’t care where or how you get these into your system, but as always, these other cannabinoids work best with THC. There are vape pens with 50/50 CBD & CBG, but none that incorporate CBC or CBN that I’ve found, yet, but they gotta be out there.

I’m looking for a good supplier of isolates of these cannabinoids; pure, plant-derived organic powders. My intent is to mix them with honey and select terpenes to put into beverages. I’m going to make a daytime version with THCV, a nighttime version that includes CBN, and a neutral one with neither. When I find that supplier I’ll paste a link here, and I'll also let you know if my hypothesis that taking these cannabinoids orally, followed by consumption of THC products a short time later works effectively.

Remember: cannabinoids every day help keep the doctor away!