#Clinical_Trials

[phonemantra-blog]

Venclexta: Revolutionizing Cancer Treatment In the world of cancer treatment, hope is often a powerful motivator. Imagine a drug that offers not just hope but tangible results. That's precisely what Venclexta represents – a beacon of hope, a game-changer in the fight against cancer.  Understanding Venclexta At its core, Venclexta is not just another medication. It's a targeted therapy designed to disrupt cancer at its roots. Understanding how it works is the first step in appreciating its potential. venclexta What is Venclexta? Venclexta is a breakthrough medication approved to treat specific types of blood cancers. At its heart, it's a small molecule that packs a powerful punch against cancer cells. The Mechanism of Action Let's break down the science: How does Venclexta zero in on cancer cells while sparing healthy ones? Approved Indications Venclexta is making waves in the treatment of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). Discover why it's considered a game-changer.  Indications and Usage Venclexta is a precision tool in the oncologist's arsenal, but it's essential to understand when and how it's used. Let's delve into its indications and optimal usage. Targeted Cancer Types Venclexta is primarily prescribed for CLL and AML. We'll explore why these types of cancers respond well to this treatment. The Role of Genetic Markers Genetic markers play a significant role in determining who will benefit most from Venclexta. Learn how these markers guide treatment decisions. Personalized Treatment Plans Every patient's journey is unique. Discover how oncologists tailor Venclexta treatment plans to individual needs. ��Benefits and Efficacy Venclexta's impact extends beyond statistics; it changes lives. Let's delve into the real-world benefits and efficacy of this remarkable medication. Improved Survival Rates Explore the data that showcases how Venclexta has improved survival rates and offered new hope to patients. Quality of Life Beyond survival, Venclexta often leads to a better quality of life. Discover how it helps patients live more fully. Side Effects and Safety While Venclexta offers tremendous promise, it's important to acknowledge potential side effects and the safety measures in place. Potential Side Effects Understand the range of side effects associated with Venclexta and how healthcare providers manage them. Monitoring and Safeguarding Learn about the regular check-ins and precautions to ensure patient safety during Venclexta treatment.  Treatment Journey with Venclexta Navigating the Venclexta treatment journey is a collaborative effort between patients and healthcare providers. Here's what to expect: Dosage and Administration Get insights into the dosing schedule and administration of Venclexta. Follow-Up Care Discover the importance of follow-up appointments and monitoring to track progress and manage side effects. Patient Experience Real stories from patients who have undergone Venclexta treatment provide valuable insights into what the journey entails. Shared Patient Experiences Hear from individuals who have experienced the transformative power of Venclexta. Challenges and Triumphs Understand the emotional and physical challenges patients face and how they overcome them.  Venclexta vs. Traditional Treatments Comparing Venclexta with conventional cancer treatments can provide a clearer perspective on its advantages and potential drawbacks. The Paradigm Shift Explore how Venclexta represents a shift in cancer treatment paradigms. Advantages and Considerations Understand the benefits Venclexta offers in terms of efficacy and reduced side effects compared to traditional treatments. Ongoing Research and Future Prospects The world of cancer research is ever-evolving. Stay up-to-date with the latest developments involving Venclexta. Current Research Highlight ongoing clinical trials and research related to Venclexta across various cancer types. The Future of Venclexta Explore the potential applications of Venclexta beyond its current indications and its role in advancing cancer care. Patient Support and Resources Navigating cancer treatment can be challenging, but there are support networks and resources available to help patients and their families. Support Organizations Highlight organizations and communities dedicated to helping Venclexta patients. Financial Assistance Discuss programs and resources that offer financial aid to ease the burden of treatment costs. Patient Education Provide information on educational materials and resources to empower patients with knowledge. Frequently Asked Questions (FAQs) About Venclexta What is Venclexta? Venclexta is a prescription medication used to treat certain types of cancer, including chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). It's a targeted therapy that works by inhibiting the BCL-2 protein. How does Venclexta work in treating cancer? Venclexta works by blocking the action of the BCL-2 protein, which helps cancer cells survive. By inhibiting BCL-2, Venclexta promotes cancer cell death and can slow down the progression of the disease. Which types of cancer is Venclexta approved to treat? Venclexta is approved for the treatment of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) in specific patient populations. It may be prescribed in combination with other medications. What are the common side effects associated with Venclexta? Common side effects of Venclexta may include nausea, diarrhea, fatigue, and respiratory tract infections. However, the side effects can vary from person to person. What should I discuss with my healthcare provider before starting Venclexta? Before starting Venclexta, it's important to discuss your medical history, current medications, and any potential allergies with your healthcare provider. They will assess whether Venclexta is suitable for you. How is Venclexta administered to patients? Venclexta is typically taken orally in the form of tablets. Your healthcare provider will provide specific dosing instructions based on your condition. What is the typical treatment duration with Venclexta? The duration of Venclexta treatment can vary depending on the type and stage of cancer. Your healthcare provider will determine the appropriate treatment plan and duration. Are there any potential drug interactions with Venclexta? Yes, Venclexta can interact with other medications. It's essential to inform your healthcare provider about all the medications and supplements you are taking to prevent potential interactions. What monitoring and follow-up are necessary during Venclexta treatment? During Venclexta treatment, your healthcare provider will monitor your progress, conduct regular blood tests, and assess for any side effects. Follow-up appointments are essential for your safety and treatment effectiveness. Can Venclexta be used in combination with other cancer therapies? Yes, Venclexta is often used in combination with other cancer treatments, such as chemotherapy or immunotherapy, as determined by your healthcare provider. Combination therapies may enhance its effectiveness. Conclusion we bring together all the key aspects of Venclexta and the impact it has on cancer care. Summarize the essential points about Venclexta's mechanism of action, benefits, and patient experiences.Encourage hope and optimism for patients and their families, emphasizing that progress in cancer treatment continues.

[jobrxiv]

STAFF ASSOCIATE I Columbia University See the full job description on jobRxiv: https://jobrxiv.org/job/columbia-university-27778-staff-associate-i-3/?feed_id=86032 #clinical_trial #exercise_science #staff_associate #ScienceJobs #hiring #research

[drrainassafehandsclinic]

Many continuing clinical trials, however, test alternative therapies.  As long as clinical results are available, the WHO will continue to provide updated information with Dr. Raina's Safe Hands Clinic.

[bgosoftware-blog]

BGO Software Launches Clinicubes CTMS to Simplify Study's Complexity

[endometriosisaustralia]

We NEED you HELP! ***#endoresearch*** TAG & SHARE 💛 Your menstrual health matters! https://nicm.edu.au/research/clinical_trials/menstrual_health Researchers at NICM Health Research Institute (NICM) and the School of Education at Western Sydney University are hoping to change the way young women think about, and deal with their periods. Research shows that women often suffer with pain and other symptoms for years before presenting to their doctor, and this is a major cause in the delay in diagnosis and treatment for endometriosis and other pelvic pain conditions. We think that the ‘normalising’ of pain and other symptoms is a big part of this delay. We are currently running a study using a web-based resource that you can use on your phone, tablet or computer. The aim of this resource is to give young women a better understanding of what’s ‘normal’ and what’s not, and how they can manage the impact of their menstrual symptoms. To help with this we are using a screening tool developed by the Canberra Endometriosis Centre (called PIPPA) to help guide women to their doctor if they show symptoms that put them at high risk of endometriosis, as well as offering a letter to take to their doctor, if they want one. We are also providing a wealth of self-care information including diet, yoga, heat and acupressure for those women who have more mild symptoms, so that they may be able to help manage their symptoms better. We are currently looking for young women, aged 14-25 who live in Australia to take part in this study. If you or anyone you know would be interested then go here to find out more https://nicm.edu.au/research/clinical_trials/menstrual_health #endoaustralia #NICM @westernsydneyu #1in10 #endometriosisaustralia #endo #endometriosis

[heymiss-miss]

Re: Covid vaccine safety concerns

Re: Covid vaccine safety concerns

As a person with a science background (MSc in pharmacology/toxicology studying viruses plus lots of immunology papers), I think it’s important to share my thought process since I do have extra scientific information that could help people that may be concerned about the coronavirus vaccine safety.  It’s a long post, so please skip to the questions you might have. I did write those in all caps.

 For general details to how vaccines work and why they are safe, here is the lesson material and even a video recording explaining it to my students. I can’t remember if in this video we talked about the coronavirus, but I know we definitely did during that topic I was teaching (microorganisms). I have linked just the vaccine one, but if you search the rest of my Google Site you can get more information related to viruses, and the immune system.

 Here are two good videos that explain how the immune system and vaccines worth. You can watch it in either order. The immune system one isn't necessary to understand how vaccines work, just gives you more context to what a beautiful system it is and why we want to use it instead of creating drugs.

 Vaccine video: https://youtu.be/zBkVCpbNnkU

Immune system: https://youtu.be/zQGOcOUBi6s

 Here are some key points and responses to common concerns.

What is the difference between bacterial and viral infections? Both of these are pathogens (things that make you sick) but the way they make you sick are very different. Bacteria are living and may or may not need a host to reproduce. Viruses are non-living and need a host to reproduce. Both have the potential to survive on surfaces or other animals, it depends what traits they have. We are still learning all of the coronavirus’s traits, which is why instructions from scientists change. One key thing we know about the coronavirus is that it can be transmitted human to human, not something we want because not it’s easier to spread. If it only transmitted from bird to human, then only people that are near birds (like chicken farmers) would need to worry. It’s always a scary step when a pathogen can jump between humans! It is also harder to fight viruses because they hide in our human cells. That means it takes more time for our immune system to notice them and start the attack! 

When drugs go through safety there is a rigorous process within drug companies. Having done a summer internship in a biotech company there was a lesson that I learned through them, “Fail fast = fail cheaply.” Basically, that means that drug companies are quick to stop working on anything that has shown or they think shows to be dangerous. The sooner they do that, the less money and time is wasted.

There is also a rigorous process in the system of drug development and governmental approval by agencies such as the FDA and MedSafe. These are known as phases and you can only move onto the next phase if you pass the previous ones. The first step is testing in cells, which are very cheap and easy to grow. The second step is to move into animals, which are more expensive and often require ethical approval (depending on the country). The third step is to move into humans. The human testing step also has steps of their own called phases. I’ll provide a link at the end if you want to read that but it’s not too important for the context of this post. Just know that it is VERY hard to get to this step and it is VERY expensive. So drug companies must feel confident when they get here.

In most countries, in order to get something approved for us, not only do you need to prove the drug to be safe, but it also needs to be effective. The general guideline of what we judge as effective is not only successful in treating the disease/symptoms but also how it compares against the best current treatment available. The large majority of drugs that go to this step still fail.

RE: BUT THE SPEED THEY PUT THIS VACCINE OUT! DID THEY DO ALL THE STEPS CORRECTLY? Yes, they still have to follow all the same steps. The reason why you see that it was developed a whole lot faster was that there was so much money thrown at the problem, there were WAY more resources to allow for processing of the data, and the bureaucracy was removed. Having money is important to buy things and pay scientists. Having more resources means that we could run programs projecting many more potential forms of the drug and if they would work basically before we even tested it in cells! Remember fail fast, fail cheap? Saves money and time. The bureaucracy being removed was important because it now forces companies to not only share the information with the government but with each other. That’s why not only have we gotten a fast solution, but many different companies putting out their version of a vaccine. That’s why we got stuff in a year. None of these things is normal in science and since there is a high risk of failing safety testing, there is a very low chance of return on investments. That’s why drug companies “spread their eggs” on multiple projects and each project only gets a limited number of resources and money. That’s why on average a new drug would require 10 years of research and development.

RE: I HEAR THEY USED DNA IN THESE VACCINES WHAT IF THAT CHANGES MY DNA? It can’t. Also, it is mRNA in the vaccine, not DNA. Currently, scientists are looking into gene therapy as a possible way of treating genetic diseases such as cystic fibrosis. Since it is a genetic disease, the only way you can change it is by changing your DNA. So far it has been largely unsuccessful. Turns out it is really hard not only to change people’s DNA but also the downstream traits the DNA controls. If we can’t do it intentionally, it’s not going to happen with this vaccine accidentally.

The mRNA vaccine works by causing the body to make a coronavirus marker. IT DOES NOT MAKE THE CORONA VIRUS AND THIS MARKER IS HARMLESS. It is important that the body has this marker so our immune system sees it and it will learn ‘not me, remember to kill this the next time I see this.’ Unfortunately, this takes time and possibly multiple exposures for the body to really learn this. Thus why when you get vaccinated it could take two weeks to be officially protected and you might need multiple injections. However, once you have it, when your body comes across it in real life it would be ready. It will fight and kill it before you get sick.

RE: I GOT SICK AFTER GETTING THE VACCINE, DID THE VACCINE MAKE ME SICK? No. See since vaccines are trying to activate the immune system, which might give you some symptoms of being sick. That’s a good sign because it means your body is building a memory of what the coronavirus looks like.

RE: I STILL GOT THE CORONA VIRUS EVEN THOUGH I WAS VACCINATED, DOES THAT MEAN IT DIDN’T WORK? If you got sick with the coronavirus soon after being vaccinated, you just got unlucky. Remember you need a two-week window from most vaccines to be protected. If you got sick with the corona later what that means your body didn’t do a good job learning the marker. It does sometimes happen, but that is rare. It is important you get both doses of the coronavirus vaccine to increase your chances of it working.

RE: WHEN SHOULD I GET THE CORONAVIRUS VACCINE? Literally, as soon as you're eligible! This needs to be rolled out as soon as possible. Not only to protect you and the population but to also prevent the virus from mutating again. See, since a virus is non-living, they require a host to reproduce. During this reproduction process, it makes mistakes, which can lead to a mutation that can cause new traits. We already saw some new traits with the new strains being more infectious. Other scary things that could happen is that it mutates and now it kills young people or children! The other scary thing is if it mutates and changes markers. That means that our current vaccines won’t work and we have to start over. We need to do everything possible to limit transmitting this virus - getting vaccinated, wearing masks, locking down, social distancing, washing hands, keeping a record of where you’ve been for contact tracing. These will limit the number of potential hosts and thus mutations.

RE: I WANT THE CORONAVIRUS VACCINE NOW BUT THEY WON’T GIVE IT TO ME! Since there is currently limited supply (don’t worry, there will be more) and limited resources to distribute them, most countries are starting with people running isolation facilities and healthcare workers to help limit the risk of it spreading, limit the risk of the people most likely to get it and to keep both of those systems running. The next lot will be those that are in a high-risk category - aka the ones that are likely to die/need serious medical attention if they do catch it. Then it will be everyone else.

That’s basically my thought process is how I weighed the pros/cons of the coronavirus vaccine based on science. I hope reading this has convinced you to get the vaccine and/or empowered you to convince others. I know people have genuine concerns, which is often the result of lack of information, so I hope I’ve answered them. Lastly, I hope it also convinces you to follow the various health guidelines as well if you weren’t doing so already.

 TLDR: Get the coronavirus vaccine as soon as you’re eligible and follow the advice of the health care professionals: wearing masks, locking down, social distancing, washing hands, keeping a record of where you’ve been for contact tracing.

 Extra information on human drug trial phases: https://www.nccn.org/patients/resources/clinical_trials/phases.aspx#:~:text=Phase%20II%20trials%20further%20assess,combinations%20of%20drugs%20are%20tested

[biedexcom]

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[jobrxiv]

STAFF ASSOCIATE I Columbia University See the full job description on jobRxiv: https://jobrxiv.org/job/columbia-university-27778-staff-associate-i-3/?feed_id=85755 #clinical_trial #exercise_science #staff_associate #ScienceJobs #hiring #research

[sudheervanguri]

Clinical Research, SAS programmer, medical writer job vacancies #clinicalresearchjobs #clinical_trial https://www.instagram.com/pharmastuff2/p/CXJMMKSB_Zz/?utm_medium=tumblr

[smestreet]

Sun Pharma's AQCH - Phytopharmaceutical Drug Goes into Phase 2 Clinical Trial for COVID-19 Treatment

#Sun_Pharma's #AQCH - #Phytopharmaceutical Drug Goes into Phase 2 #Clinical_Trial for #COVID19 Treatment

Sun Pharmaceutical Industries has started phase two clinical trial on AQCH, a phytopharmaceutical (plant-derived) drug for the treatment of COVID-19.

The company got approval from Drugs Controller General of India (DCGI) for conducting phase two clinical trial in April. The clinical trial will be conducted across 12 centres in India on 210 patients with a duration of 10 days.

The results of the…

[endometriosisaustralia]

*** ENDO RESEARCH *** Call for participants: Chinese Herbal Medicine for Endometriosis – Clinical trial . Researchers from @westernsydneyu and the @unsw , led by #DrMikeArmour, are currently running a clinical trial on the effectiveness of a modification of a traditional Chinese medicine formula (Gynoclear) on the symptoms of #endometriosis. . This trial is open to women #Australia wide and will involve having two blood tests, one at the start and one at the end of the trial, filling in online pain and symptom diaries, and taking six capsules per day for three months. . This is a placebo-controlled trial so there is a 50% chance you will get a placebo or the active treatment, however, all women in the placebo group will receive three months’ supply of Gynoclear at the end of the trial. . To find out more and to take part in our screening checklist go to https://nicm.edu.au/research/clinical_trials/endometriosis_study (link 🔗 in stories) . #endoresearch #endometriosisaustralia #endo #1in10 #NICM #health #womenshealth #TCM #complementarymedicine #chineseherbs #herbs https://www.instagram.com/p/Bz64-YHgg9a/?igshid=1aceycq0e2dgd

[keeganybal423-blog]

Exists A Remedy For Rest Apnea?

Each individual is different, but every human runs by the very same code. This particular sleep disorder generally runs in the household. Being a guy is another factor, as guys have airway that are narrower than those of ladies.

Just How To Stop Snoring By All-natural Ways With 5 Really Easy Workouts!

There is a means by which to self-check if you may perhaps be suffering from sleep apnea. By addressing standard concerns, you might already do a sleep apnea test on your own. Attempt browsing for sleep apnea tests on the web. It has questions to assess if you're http://academicdepartments.musc.edu/medicine/divisions/pulmonary/research/clinical_trials/sleep_apnea.htm revealing indicators of sleep apnea. Very loud snoring and having breaks in inhalation whilst sleeping is the significant sign of sleep apnea. If the evaluation shows that you have actually got the majority of the symptoms, then it's time to confirm this with your medical physician.

Boost Quality Of Life With Rest Problem Help

In truth, snoring is just one aspect of sleep apnea Bella vista (OSA), which is an issue for lots of obese individuals. When you have OSA you are not breathing in addition to you should, and the outcome is that your body is not getting all the oxygen that it needs.

Anti Snoring Mouthguards - A Reputable Snoring Solution

If your battle to sleep stems from a failure to get your mind to calm down, meditation is among the best ways to fall asleep faster. In fact I recently read a story about a persistent insomniac who had actually attempted whatever from medication (Serzone, Wellbutrin, Sonata and Ambien!) to a visit to a hypnotist and nothing worked. She also hung out in a sleep services Hurstville to no avail. It was only when she began practicing meditation that she lastly started to get a full 7 hours of sleep at night.

New Treatments For Sleep Apnea

2) You are in the category of being at high threat for medium to critical sleep apnea. The danger includes breathing pauses while sleeping that have been recorded or witnessed, being severely overweight, extreme drowsiness throughout the day and snoring that is loud and frequently.

Dealing with Obstructive Sleep Apnea Or Losing Your Job

Prior to you make a decision, likewise consider your own needs. The majority of moms and dads are healthier for having a long time to themselves after the kids go to bed. Consider putting the boy to bed earlier and waking him up previously. It won't hurt him, and it might be healthier for you.

[biedexcom]

The Latest: US to start distributing experimental virus drug#stockmarkets#2019-2020_coronavirus_pandemic #arts_and_entertainment #business #clinical_trials #contracts_and_orders #coronavirus #corporate_news #diagnosis_and_treatment #disease_outbreaks #diseases_and_conditions #distributing #drug #drug_trials #entertainment #epidemics #experimental #general_news #government_and_politics #health #health_care_industry #holidays #humanitarian_crises #immunizations #infectious_diseases #latest #latin_music #lifestyle #lung_disease #medical_research #medication #music #occasions #pandemics #pharmaceutical_manufacturing #product_testing #products_and_services #public_health #religion #religion_and_politics #religious_issues #social_affairs #social_issues #start #thanksgiving #virus

[preeti-agarwal-stuff-blog]

Clinical Research is a most knowledge intensive and interesting field in pharmaceutical industry. The billion dollar industry is demanding the employment opportunities of qualified and trained professionals in clinical research sector.