#Cell Culture Protein Surface Coating

[acumenblog]

Cell Culture Protein Surface Coating Market Revenue Expected to Strengthen, Reaching USD 3,145 Million by 2032 with a 14.8% CAGR from 2023 to 2032

Acumen Research and Consulting has recently published a research report on the Cell Culture Protein Surface Coating Market for the forecast period of 2023 – 2032, wherein, the global market has been analyzed and assessed in an extremely comprehensive manner. The research report on the Cell Culture Protein Surface Coating Market offers an extensive analysis of how the postoperative pain…

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Growing demand for the use of 3D cell culture techniques is a major factor fueling the growth of Cell Culture Protein Surface Coatings market. Asia Pacific...

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The Global Cell Culture Protein Surface Coatings market is anticipated to rise at a considerable rate during the forecast period, between 2023 To 2030. In 2022, the market is growing at a steady rate and with the rising adoption of strategies by key players, the market is expected to rise over the projected horizon.

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Cell Culture Protein Surface Coating Market

Cell Culture Protein Surface Coating Market Size, Share, Trends: Corning Incorporated Leads

Growing Use of 3D Cell Cultures for Drug Research and Tissue Engineering

Market Overview:

The global Cell Culture Protein Surface Coating Market is expected to increase at a compound annual growth rate (CAGR) of 12.5%, reaching USD 1.8 billion by 2031 from USD 789.5 million in 2022. North America is the industry leader because of its high level of research effort and concentration of major biotechnology businesses. The demand for cell-based research is expanding, and 3D cell culture technological advancements and increased funding for stem cell research are driving this growth in the Cell Culture Protein Surface Coating market. The increasing usage of cell culture techniques in response to the increased awareness of regenerative therapies and customised medicine highlights the need for protein surface coatings. Further driving market expansion are the growing biopharmaceutical sector and the move towards chemically defined, animal-free manufacturing processes.

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Market Trends:

Driven by the need for increased reproducibility, safety, and regulatory compliance, the cell culture industry is clearly moving toward chemically defined and xeno-free culture techniques. This tendency is seriously influencing the cell culture protein surface coating industry. Conventional animal-derived coatings like collagen and fibronectin are being replaced more and more by synthetic and recombinant replacements. Among its many advantages are batch-to-batch homogeneity, less risk of contamination, and better control of cell activity by means of these chemically defined coatings. Moreover, xeno-free coatings eliminate problems regarding animal-derived components, so they are ideal for clinical applications and stem cell research.

Market Segmentation:

Pre-coated surfaces lead the cell culture protein surface coating industry as they provide researchers ready-to-use, consistent solutions saving time. By eliminating the need for internal coating processes and hence reducing variance, these products increase experimental reproducibility. Pre-coated surfaces are particularly sought after in applications such high-throughput screening and routine cell culture operations, where uniformity and efficiency are absolutely critical. Customized pre-coated products that fit certain cell types and research goals are becoming available, thus meeting the many needs of the scientific community and therefore boosting the segment's predominance.

Market Key Players:

The Cell Culture Protein Surface Coating sector is characterized by constantly innovative ideas and fierce competition. Important companies are focusing on developing novel coating formulations, expanding their product lines, and raising their geographical presence by means of strategic partnerships and acquisitions. Key companies such as Corning Incorporated, Thermo Fisher Scientific Inc., Merck KGaA, Sigma-Aldrich Corporation, BioLamina AB, Roche Diagnostics, EMD Millipore, Bio-Techne Corporation, PerkinElmer Inc., and Biomedical Structures LLC dominate the market.

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3D Cell Culture Market 2030: Brief Analysis of Top Countries Data, Growth and Drivers

The global 3D cell culture market size is anticipated to reach USD 3.21 billion by 2030 and is anticipated to expand at a CAGR of 11.22% during 2024 to 2030, according to a new report by Grand View Research, Inc. The market is driven by technological advancements in in-vitro testing models, a rising focus on personalized medicine, and supportive government legislation for R&D. Moreover, the increasing prevalence of chronic disorders, and the growing significance of cell therapies in their treatment have created momentum for industry expansion.

Tissue engineering has made significant developments in creating 3D culture models that mimic the in-vivo culture media more precisely than the conventional 2D cell cultures. This resulted in increased utilization of 3D cell culture systems for toxicity testing, drug discovery, and regenerative medicine development. Also, recent product launches from industry players have supported market growth to a significant extent. For instance, in June 2023, Pixelgen Technologies launched its first molecular pixelation kit for 3D spatial study of proteins present on cell surface.

Gather more insights about the market drivers, restrains and growth of the Global 3d cell culture market

3D Cell Culture Market Report Highlights

The scaffold-based technology segment dominated the market in 2023 with a revenue share of 48.94% and is attributed to the increasing application of scaffold-based cultures in tissue engineering and regenerative medicine applications

Stem cell research & tissue engineering held the largest share in 2023, whereas the cancer institute segment is expected to witness the fastest growth owing to the rising prevalence of cancer, and the benefits offered by 3D cell cultures in cancer research

In the end-use segment, biotechnology and pharmaceutical companies dominated the market with a revenue share in 2023. The higher revenue growth is attributed to the continuous growth and commercial success of biopharmaceuticals coupled with the expanding portfolio of the major pharmaceutical companies

North America region dominated the global market in 2023 with a revenue share of 38.97%, owing to the presence of advanced healthcare infrastructure, developed economies, the presence of key players, and various strategic initiatives undertaken by them

Browse through Grand View Research’s Biotechnology Industry Research Reports.

DNA & Gene Chip Market: The global DNA & gene chip market size was valued at USD 9.96 billion in 2023 and is projected to grow at a compound annual growth rate (CAGR) of 12.3% from 2024 to 2030.

Cell Sorting Market: The global cell sorting market size was valued at USD 242.7 million in 2023 and is projected to grow at a compound annual growth rate (CAGR) of 8.6% from 2024 to 2030.

3D Cell Culture Market Segmentation

Grand View Research has segmented the global 3D cell culture market based on technology, application, end-use, and region:

3D Cell Culture Technology Outlook (Revenue, USD Billion, 2018 – 2030)

Scaffold Based

Hydrogels

Polymeric Scaffolds

Micropatterned Surface Microplates

Nanofiber Base Scaffolds

Scaffold Free

Hanging Drop Microplates

Spheroid Microplates with ULA Coating

Magnetic Levitation

Bioreactors

Microfluidics

Bioprinting

3D Cell Culture Application Outlook (Revenue, USD Billion, 2018 – 2030)

Cancer Research

Stem Cell Research & Tissue Engineering

Drug Development & Toxicity Testing

Others

3D Cell Culture End-Use Outlook (Revenue, USD Billion, 2018 – 2030)

Biotechnology and Pharmaceutical Companies

Academic & Research Institutes

Hospitals

Others

3D Cell Culture Regional Outlook (Revenue, USD Billion, 2018 – 2030)

North America

Europe

Asia Pacific

Latin America

Middle East & Africa

Order a free sample PDF of the 3D Cell Culture Market Intelligence Study, published by Grand View Research.

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Cell Culture Protein Surface Coatings Market Worth $2575.0 Million By 2030

The global cell culture protein surface coatings market size is expected to reach USD 2575.0 million by 2030, registering a CAGR of 15.29% from 2023 to 2030, according to a new report by Grand View Research, Inc. Increasing focus on stem cell research and development is the most crucial factor that drives the industry growth. Stem cell therapy is the most promising method to treat severe medical…

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Trends Impacting Microcarriers Market Size

The Microcarriers Market size was estimated at USD 1.52 billion in 2023 and is expected to reach USD 3.68 billion by 2031 at a CAGR of 11.7% during the forecast period of 2024-2031.The microcarriers market is experiencing significant growth, driven by the increasing demand for cell-based therapies and advancements in biopharmaceutical production. Microcarriers, which provide a surface for cell attachment and growth in suspension cultures, are becoming indispensable in the large-scale production of vaccines, monoclonal antibodies, and regenerative medicine. Innovations in microcarrier technology, such as the development of biodegradable and magnetic microcarriers, are enhancing the efficiency and scalability of cell culture processes. Additionally, the expanding research in stem cell therapy and tissue engineering is further propelling market growth, positioning microcarriers as a crucial component in modern biotechnology and medical research.

Get Sample Copy Of This Report @ https://www.snsinsider.com/sample-request/3837

Market Scope & Overview

The research looks into the major variables affecting the expansion of the global market. The report used a bottom-up approach to gather and forecast data for a wide range of industrial verticals and end-user industries, as well as their reach across several categories, in order to determine the overall size of the Microcarriers Market  throughout the forecast period. Market actors may use market data to create plans to improve their competitive position.

The Microcarriers Market  research report covers all of these topics in great detail, including the Porter's Five Forces analysis, significant segments, drivers, opportunities, and the competitive environment. For business experts, stakeholders, investors, VPs, and newcomers who want to learn more about the company and formulate a competitive strategy, this study is an excellent resource.

Market Segmentation Analysis

By Consumable

Media & Reagents

Microcarrier Bead

Collagen Coated Beads

Cationic Beads

Protein Coated Beads

Untreated Beads

Others

By Application

Biopharmaceutical Production

Vaccine Production

Therapeutic Production

Regenerative Medicine

By End User

Pharmaceutical & Biotechnology Companies

Contract Research Organizations & Contract Manufacturing Organizations

Academic & Research Institutes

COVID-19 Impact Analysis

Due to the COVID-19 lockout, it was necessary to create original strategies for dealing with future occurrences while sustaining steady growth. The market research report also provides advice for overcoming pandemic-like situations and lessening their harmful effects. The Microcarriers Market  was significantly impacted by the COVID-19 epidemic. Due to delays in new developments, the industry has also been suspended internationally.

Regional Outlook

With a focus on North America, Latin America, Europe, Asia Pacific, and the Middle East and Africa, the Microcarriers Market  research report digs into market aspects including estimations for total price from top manufacturers and trends toward advancement in various regions of the world.

Competitive Analysis

The research report offers a complete analysis of the worldwide Microcarriers Market  and suggests important adjustments that market players should take into account when developing their business plans. To gain market dominance, these companies have used partnerships, product development, joint ventures, mergers and acquisitions, diversification, and joint ventures.

Key Reasons to Purchase Microcarriers Market  Report

To identify important geographic regions and leading nations that have a substantial impact on market revenue, the researchers conduct geographic study.

Prospect information may be used by market participants to evaluate potential and formulate their next moves.

Report Conclusion

Manufacturers, distributors, dealers, and policymakers may use the data from the market research report to assess which industry sectors should be prioritized in the upcoming years in order to plan investments and take advantage of the Microcarriers Market  expansion.

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Artificial mucus identifies link to tumor formation - Technology Org

New Post has been published on https://thedigitalinsider.com/artificial-mucus-identifies-link-to-tumor-formation-technology-org/

Artificial mucus identifies link to tumor formation - Technology Org

Excess mucus is a common, unpleasant symptom of illness during cold and flu season, but the slippery substance is essential to human health. To better understand its many roles, researchers synthesized the major component of mucus, the sugar-coated proteins called mucins. They discovered that changing the mucins of healthy cells to resemble those of cancer cells made healthy cells act more cancer-like.

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The researcher will present her results today at the American Chemical Society (ACS) spring meeting. ACS Spring 2024 is a hybrid meeting held virtually and in person March 17-21; it features nearly 12,000 presentations on a range of science topics.

“For hundreds of years, mucus was considered a waste material or just a simple barrier,” says Jessica Kramer, a professor of biomedical engineering who led the study. And indeed, it does serve as a barrier, regulating the transport of small molecules and particulates to underlying epithelial cells that line the respiratory and digestive tracts. But it also does much more. Studies show that mucus and mucins are biologically active, playing roles in immunity, cell behavior and defense against pathogens and cancer. Kramer’s team at the University of Utah, for example, recently found that specific sugars attached to mucins inhibited coronavirus infection in cell culture.

“Part of the challenge of studying mucus and mucins in general is that they have quite a variety of protein structures,” Kramer explains. Although humans share more than 20 mucin genes, those genes are expressed differently in different tissues and are spliced to generate a range of proteins. In addition, cells modify those proteins in myriad ways with different sugars to meet the body’s needs.

Complicating the picture, genetic factors alone don’t determine mucin composition. Dietary and environmental factors can also influence which sugars become attached to these proteins. Thus, mucus composition can vary significantly from person to person, from day to day, and from tissue to tissue, all of which makes it difficult to identify the biological effects of any given mucin.

To study mucin properties, researchers can collect mucus from slaughterhouse animals, Kramer says. “But ultimately, it’s quite labor intensive and difficult to purify. And in the harvesting process, the sticky, slimy properties are usually disrupted.”

Synthetic mucus is revealing how the slimy substance impacts human health and disease, including protection against infection and cancer. Image credit: Jessica Kramer

As an alternative, mucins can be purchased off-the-shelf, Kramer explains. But because batch-to-batch variability can lead to problems with experimental reproducibility, methods are needed to reliably produce synthetic mucins at scale and at a reasonable price.

In the absence of a simple genetic method to produce individual mucins, Kramer’s lab combined synthetic chemistry and bacterial enzymes to generate the core polypeptides and then selectively add sugars to create unique synthetic mucins. This allows the researchers to test the physical, chemical and biological properties of individual types of mucin molecules and identify the impact of changing individual sugars or protein sequences.

Kramer, along with the lab of collaborator Jody Rosenblatt at King’s College London, is applying her team’s mucins to questions of cancer biology. In particular, the scientists are exploring the influence of mucins on the earliest stages of tumor formation. Previous studies in other labs have shown that mucins embedded in the surface of cancer cells promote metastasis, the spread of cancer to other tissues in the body. These mucins can also help the cancer cells evade immune system defenses by blocking immune cell activation.

“We are building synthetic mucins to understand how the chemical aspects of these proteins affect the behavior of cancer cells,” Kramer explains. “It hasn’t been possible to study these things before because we can’t control the molecular properties of mucins using traditional genetic and biochemical methods.”

Normally, as non-cancerous epithelial cells grow, they crowd together, with some getting eliminated from the epithelial layer to maintain a consistent and stable tissue structure. When Kramer’s team engineered the cells to have a bulky mucin-rich surface similar to that of cancer cells, the cells stopped extruding normally and piled up, forming what looked like the start of tumors.

Kramer is quick to note, however, that her team has not determined whether the genetics of the cells have changed, so they cannot yet state definitively whether the healthy cells were transformed into cancer cells. Those studies are ongoing.

The insights will be pivotal for the development of possible cancer treatments targeting mucins, as they will help highlight which parts of the mucin molecules are most important to tumor formation.

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Scientists have been trying to make mucin-targeting therapeutics for decades, but that hasn’t worked well, in part because the sugar groups on the molecules weren’t fully taken into account, Kramer says. “For a vaccine, we can’t only consider the protein sequence because that’s not what the molecule looks like to the immune system. Instead, when an immune cell bumps into the surface of a cancer cell it’s going to see the sugars first, not the protein backbone.” So she believes an effective vaccine will need to target those mucin sugars.

Beyond cancer, the ability to reliably modify the protein sequence and sugars and produce scalable quantities of synthetic mucins offers opportunities to develop these molecules as anti-infectives, probiotics and therapies to support reproductive and women’s health, Kramer says.

Source: acs.org

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Classification and characteristics of elisa plate

Enzyme-Linked Immunosorbent Assay (ELISA) is a commonly used laboratory technique that allows the detection and quantification of specific proteins or antibodies in a sample. ELISA plates, also known as microtiter plates, are the primary tools used in ELISA experiments. These plates are typically made of a transparent polystyrene material and consist of multiple wells arranged in a grid-like pattern.

Here are the classifications and characteristics of ELISA plates:

1.Well Types:

a. Flat-bottomed wells: These wells have a flat bottom surface and are commonly used for colorimetric ELISAs, where the absorbance of the wells is measured.

b. Round-bottomed wells: These wells have a rounded or conical bottom and are often used for fluorescent or luminescent ELISAs, where the signal is measured in a plate reader.

2.Coating:

a. Non-specific binding (NSB) plates: These plates have a high-binding surface that maximizes the adsorption of proteins or antibodies to the plate's surface. They are ideal for assays where high sensitivity is required.

b. Blocking plates: These plates are pre-coated with blocking agents (e.g., BSA or gelatin) to prevent non-specific binding of proteins and reduce background noise. They are used to minimize false-positive signals.

3.Surface Chemistry:

a. Polystyrene plates: Polystyrene plates are the most common type and offer good binding capacity for proteins and antibodies.

b. Polyvinyl chloride (PVC) plates: PVC plates are less common but can be used in certain applications.

c. Specialty plates: Some ELISA plates have specialty coatings or modifications to enhance specific interactions or improve sensitivity. For example, some plates have a hydrophilic surface for better liquid distribution.

Elisa Plate

4.Well Format:

a. 96-well plates: These are the most commonly used format, with 96 wells organized in a 8x12 grid.

b. 384-well plates: These plates have smaller wells in a 16x24 grid, allowing higher throughput and reduced sample volume requirements.

c. Other formats, such as 24-well or 384-well plates: These formats may be used for specific applications or when smaller sample sizes are available.

5.Sterility:

a. Sterile plates: Some ELISA plates come pre-sterilized and individually wrapped for use in sterile laboratory conditions or cell culture applications.

6.Compatibility:

a. Plate readers and washers: ELISA plates are designed to be compatible with automated plate readers and washers, allowing for efficient sample processing, data acquisition, and analysis.

When selecting an ELISA plate, it's important to consider the specific requirements of your assay, such as the type of detection method, sample volume, and sensitivity needed. Choosing the appropriate plate ensures optimal performance and reliable results in your ELISA experiments.

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Growing demand for the use of 3D cell culture techniques is a major factor fueling the growth of Cell Culture Protein Surface Coatings market. Asia Pacific...

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The Role of Human Serum Albumin in Cell Culture: Benefits and Applications

Introduction:

In cell culture, the presence of essential components is crucial to ensure the growth, survival, and proper functioning of cells. One such vital component is human serum albumin (HSA), a versatile protein found in human blood plasma. This article explores the significance of HSA in cell culture, its benefits, and its applications in various research and biotechnological fields.

Importance of Human Serum Albumin in Cell Culture:

Human serum albumin plays a pivotal role in cell culture due to its diverse functions and unique properties. It acts as a carrier for essential nutrients, hormones, and metals, ensuring their efficient transport into cells. Additionally, HSA stabilizes pH levels and maintains osmotic pressure, creating a conducive environment for cell growth and metabolism.

Benefits of Using Human Serum Albumin in Cell Culture:

(a) Enhanced Cell Viability: HSA's ability to scavenge harmful reactive oxygen species (ROS) helps protect cells from oxidative stress, thus promoting enhanced cell viability and reducing cell death.

(b) Improved Cell Attachment and Proliferation: HSA-coated surfaces facilitate better cell adhesion, leading to improved cell proliferation and more reliable experimental results.

(c) Efficient Nutrient Transport: The high binding capacity of HSA enables efficient transport of lipids, fatty acids, and other nutrients required for optimal cell growth and function.

(d) Minimized Cellular Stress: Adding HSA to the cell culture medium reduces the risk of serum starvation-induced stress, which can be particularly beneficial for sensitive cell lines.

Applications of Human Serum Albumin in Cell Culture:

(a) Biopharmaceutical Production: HSA is commonly used in the production of biopharmaceuticals, including vaccines and therapeutic proteins, as it enhances the yield and stability of cell lines used for expression.

(b) Cell-Based Assays: HSA serves as an essential component in various cell-based assays, such as drug screening, toxicity testing, and receptor-binding studies, providing a more physiologically relevant environment for cellular responses.

(c) Tissue Engineering: HSA contributes to tissue engineering applications, promoting cell growth and tissue regeneration in engineered constructs.

(d) In Vitro Fertilization: HSA has been utilized in assisted reproductive technologies, including in vitro fertilization (IVF), to support embryo development and increase the success rates of fertility treatments.

Conclusion:

human serum albumin cell culture plays a vital role in cell culture, providing numerous benefits that enhance cell viability, proliferation, and functionality. Its applications in biopharmaceutical production, cell-based assays, tissue engineering, and reproductive technologies make it an indispensable component in modern cell culture practices. As researchers continue to explore the intricacies of cell biology, HSA remains a valuable tool to support advancements in various scientific and medical fields.

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Adroit market research report on global cell culture protein surface coatings market gives a holistic view of the market demand, trends and opportunities.